Digital Commons Network^™

Sexually Transmitted Infection Prevalence Among Women At Risk For Hiv Exposure Initiating Safer Conception Care In Rural, Southwestern Uganda, Pooja Chitneni, Mwebesa Bosco Bwana, Moran Owembabazi, Kasey O'Neil, Paul Kato Kalyebara, Winnie Muyindike, Nicholas Musinguzi, David R. Bangsberg, Jeanne M. Marrazzo, Jessica E. Haberer, Angela Kaida, Lynn T. Matthews

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background Knowledge of sexually transmitted infection (STI) prevalence and risk factors is important to the development of tenofovir-based preexposure prophylaxis (PrEP) and safer conception programming. We introduced STI screening among women at risk for HIV exposure who were participating in a safer conception study in southwestern Uganda. Methods We enrolled 131 HIV-uninfected women, planning for pregnancy with a partner living with HIV or of unknown HIV serostatus (2018-2019). Women were offered comprehensive safer conception counseling, including PrEP. Participants completed interviewer-administered questionnaires detailing sociodemographics and sexual history. We integrated laboratory screening for chlamydia, gonorrhea, trichomoniasis, and syphilis as a substudy to …

A Structural Characterisation Of Av(1324) And New Bounds On Its Growth Rate, David Bevan, Robert Brignall, Andrew Elvey Price, Jay Pantone

Mathematical and Statistical Science Faculty Research and Publications

We establish an improved lower bound of 10.271 for the exponential growth rate of the class of permutations avoiding the pattern 1324, and an improved upper bound of 13.5. These results depend on a new exact structural characterisation of 1324-avoiders as a subclass of an infinite staircase grid class, together with precise asymptotics of a small domino subclass whose enumeration we relate to West-two-stack-sortable permutations and planar maps. The bounds are established by carefully combining copies of the dominoes in particular ways consistent with the structural characterisation. The lower bound depends on concentration results concerning the substructure of a typical …

Combating Covid On College Campuses: The Impact Of Structural Changes On Viral Transmissions, Jared Knofczynski, Aria Killebrew Bruehl, Ben Warner, Ryne Shelton

altREU Projects

One of the most significant issues in the COVID-19 pandemic is the reopening of schools while minimizing the transmission of coronavirus. Opportunities for evaluating the effectiveness of policies that might be utilized at such institutions are limited, as the necessary empirical data has not been gathered yet. Agent-based modeling, where various entities within an environment are simulated as agents, offers an opportunity to examine the effectiveness of various policies in a way that drastically minimizes the health and economic risks involved. Agent-based modeling is common within biology, ecology and other fields; and has seen some use within the coronavirus literature. …

Benediction: The Teachings Of Chief Kwaxsistalla Adam Dick And The Atla’Gimma (“Spirits Of The Forest”) Dance, Douglas Deur, Kim Recalma-Clutesi, William White

Anthropology Faculty Publications and Presentations

Like the symposium that inspired this book, its contents are preceded by the words of Chief Kwaxsistalla wath-thla Adam Dick. His name, Kwaxsistalla – bequeathed to him by his father and grandfather, who had inherited the name from generations going back to the beginning of remembered time – is a chiefly title that means “smoke from his fire reaches around the world.” He was chief of the Qawadiliqalla (Wolf) Clan of the Dzawada7enuxw (Tsawataineuk) Kwakwa’kawakw from Kingcome Village on the mainland coast of British Columbia.

Evaluation Of Groundwater Sodium And Sodium Uptake In Taxodium And Its Hybrids On Galveston Island, Texas, Daniel Morgan

Electronic Theses and Dissertations

In September 2008, Hurricane Ike swept through the Gulf of Mexico striking the Gulf Coast, claiming hundreds of lives and causing billions of dollars in damage. The hurricane left behind elevated sea salt concentrations in the soil and groundwater, preventing the unaided return of live oaks and other species to the island. To determine effective ways to ameliorate the elevated Na⁺ concentrations in the soil, eight treatments were applied to the soil and combinations of three species of plants, live oak (Quercus virginiana), hybrid bald cypress (Taxodium ‘T406’), and yellow hibiscus (Hibiscus hamabo …

Causal Comparative Study: The Effect Of School Scheduling And Academic Outcomes Of Economically Disadvantaged Students, Marcus D. Brannon

Electronic Theses and Dissertations

This study was designed to investigate if a statistical variance exists between traditional and A/B block school scheduling, and the effect on economically disadvantaged student achievement on the English I and Algebra I End-of-Course STAAR state-mandated exam, from 2015-2018. In response to studies illuminating the achievement gap, educational leaders in Texas implemented block scheduling in order to improve student outcomes among high school students. However, to date, published research studies yield mixed results of the effectiveness block scheduling has made on student achievement. The findings are expected to help to fill the gap in published literature, which focuses on the …

Surface Levels, Keisha Brathwaite

Electronic Theses and Dissertations

Surface Levels are depictions of unobserved and imperceptible realities of many phytoplankton exteriors. The exhibition explores various structures, textures, and repetitious forms from microscopic surfaces of objects that cannot be seen with unaided eyes. Electron microscopy is used to perceive and analyze these otherwise unseeable surfaces in depth. Magnifications provide a reference in creating three- and two-dimensional works that are minimalistic and abstract at a visible level. This abstract 3D/2D image collection is translated into material expressions using acrylic sheets, acrylic ink, and wood as the main media for construction of individual works. Collectively, they serve to make the invisible …

Exploring The Influence Of Energy Constraints On Liquid State Machines, Andrew Fountain

Theses

Biological organisms operate under severe energy constraints but are still the most powerful computational systems that we know of. In contrast, modern AI algorithms are generally implemented on power-hungry hardware resources such as GPUs, limiting their use at the edge. This work explores the application of biologically-inspired energy constraints to spiking neural networks to better understand their effects on network dynamics and learning and to gain insight into the creation of more energy-efficient AI. Energy constraints are modeled by abstracting the role of astrocytes in metabolizing glucose and regulating the activity-driven distribution of ATP molecules to “pools” of neurons and …

Evaluation Of The Premarket Tobacco Product Application For Electronic Cigarettes, Maya Lara

Theses

Use of tobacco has remained one of the most lethal pastimes within the United States. With the creation of new products, like electronic cigarettes (e-cigarettes), more and more individuals have begun to engage in this activity. In 2019, an epidemic surrounding the use of e-cigarettes emerged causing a multitude of users to suffer harmful respiratory illnesses. These events triggered the need for further investigation not only into the research used to analyze e-cigarettes, but also the regulation process used to validate them. E-cigarettes, like their predecessor traditional cigarettes, are regulated by the Center for Tobacco Products (CTP) within the United …

Parametric Study Of Infrared Imaging Based Breast Cancer Detection Program, Carlos B. Gutierrez

Theses

Breast cancer is one of the most common cancers among women and is responsible for over 41,000 lives every year in the US according to The American Cancer Society. Current screening and imaging methods such as mammography, breast magnetic resonance imaging, and breast ultrasound imaging have helped in improving survival rate when the cancer is detected at an early stage. The problems with these techniques include: low sensitivity, patient discomfort, invasiveness, and cost. Due to current advancements in infrared and computational technologies, infrared thermography has been utilized as a noninvasive adjunctive screening modality. A computerized approach using infrared imaging (IRI) …

The Black Ceiling: The Underrepresentation Of African American Females In The Ces Professorate, Sharon Vanessa Lewis

Doctoral Dissertations and Projects

This qualitative phenomenological study highlighted the lived experiences of six African American female professors in the counseling education and supervision professorate. The professors were faculty within universities across the United States in the mid-Atlantic, southern, and midwestern regions. This study obtained data from semi-structured interviews as well as photovoice submissions from the interview participants in order to identify experiences which facilitated their persistence in the professorate and overcoming internal and external barriers. The research problem was the underrepresentation of African American females within the counseling education and supervision professorate, which further facilitates minority students’ attrition and underrepresentation. A thematic analysis …

Using Natural Language Processing And Sentiment Analysis To Augment Traditional User-Centered Design: Development And Usability Study, Curtis L. Petersen, Ryan Halter, David Kotz, Lorie Loeb, Summer B. Cook, Dawna M. Pidgeon, Brock Christensen, John A. Batsis

Dartmouth Scholarship

Background: Sarcopenia, defined as the age-associated loss of muscle mass and strength, can be effectively mitigated through resistance-based physical activity. With compliance at approximately 40% for home-based exercise prescriptions, implementing a remote sensing system would help patients and clinicians to better understand treatment progress and increase compliance. The inclusion of end users in the development of mobile apps for remote-sensing systems can ensure that they are both user friendly and facilitate compliance. With advancements in natural language processing (NLP), there is potential for these methods to be used with data collected through the user-centered design process.

Objective: This study aims …

Eagle Creek Post-Fire Monitoring For Water Temperature & Water Stage, Sylas Daughtrey

Environmental Science and Management Professional Master's Project Reports

When investigating forested watersheds devastated by wildfire, the wide range of disturbance can lead to altering hydrological effects through the loss in ground cover vegetation, canopy cover, while also disrupting soil characteristics. Within the Pacific Northwest, forested drainages affected by post-fire disturbance are further altered in areas that experience seasonal rainfall and snow melt events. When looking at the post-fire sloped areas of Eagle Creek and Tanner Creek within the Columbia Gorge of Oregon, the loss of ground cover and organic matter throughout these two watersheds pose a legitimate concern for erosion events as well as hydrological changes due to …

Science Fiction And The Law: A New Wigmorian Bibliography, Jorge L. Contreras

Utah Law Faculty Scholarship

In 1908, Dean John Henry Wigmore compiled a list of novels that no lawyer could “afford to ignore”. Wigmore’s list, taken up by Professor Richard Weisberg in the 1970s, catalogs one hundred novels, stories and dramatic works from Antigone to The Merchant of Venice to Native Son, each of which portrays or offers insight into the legal system or the practice of law. Weisberg’s updated list also includes a compilation of critical studies in the then-emerging law and literature movement. This article undertakes a similar bibliographic exercise with respect to law and the literature of science fiction. While science fiction, …

Technical Standards For Bioinformatics And Medical Informatics, Jorge L. Contreras, Adrian Thorogood

Utah Law Faculty Scholarship

With a few exceptions, the biomedical industry, and the informatics field in particular, have not been affected by the standards litigation that has plagued the ICT sector. But with the increasing adoption of standards by informatics researchers and vendors, the issues faced by ICT standards groups will become increasingly relevant. This chapter summarizes general legal issues associated with standards development, then surveys standardization efforts in the informatics space and reviews the policies and procedures adopted by SDOs operating in the informatics area. It concludes with recommendations regarding prudent policy adoption by SDOs developing standards for informatics applications.

Association For Molecular Pathology V. Myriad Genetics: A Critical Reassessment, Jorge L. Contreras

Utah Law Faculty Scholarship

The Supreme Court’s 2013 decision in Association for Molecular Pathology v. Myriad Genetics is part of the Court’s recent quartet of patent eligibility decisions, which also includes Bilski v. Kappos, Mayo v. Prometheus and Alice v. CLS Bank. Each of these decisions has significantly shaped the contours of patent eligibility under Section 101 of the Patent Act in ways that have been both applauded and criticized. The Myriad case, however, was significant beyond its impact on Sec-tion 101 jurisprudence. Perhaps one of the most remarkable things about Myriad is that it meant so many different things to so many different …

Examining The Relationship Between Cognitive Selection Criteria For Admission And Noncognitive Performance Outcomes In A Professional Graduate Degree Program, Rosalie Maiorella

Seton Hall University Dissertations and Theses (ETDs)

The admission processes in higher education have been the topic of considerable discussion and study at all levels of the institution from undergraduate to graduate and professional education. This study focused on graduate students who completed their master’s degree in Counseling and School Counseling from 2010 to 2018. Students completed their degree fully online and from a distance. The goal was to determine if admission criteria were predictive of end of program clinical fieldwork evaluations. Independent variables looked at were Undergraduate GPA (UGPA); GRE: (V)erbal, (Q)uantitative, and (W)riting; First Semester Graduate GPA (GPA1), and Cumulative Graduate GPA (GPAEP). End of …

Modulation Of Hedgehog Signaling By Kappa Opioids To Attenuate Osteoarthritis, Alexander E Weber, Omid Jalali, Sean Limfat, Ruzanna Shkhyan, Robert Van Der Horst, Siyoung Lee, Yucheng Lin, Liangliang Li, Erik N Mayer, Liming Wang, Nancy Q Liu, Frank A Petrigliano, Jay R Lieberman, Denis Evseenko

Faculty, Staff and Students Publications

OBJECTIVE: Inhibition of hedgehog (HH) signaling prevents cartilage degeneration and promotes repair in animal models of osteoarthritis (OA). This study, undertaken in OA models and in human OA articular cartilage, was designed to explore whether kappa opioid receptor (KOR) modulation via the inhibition of HH signaling may have therapeutic potential for achieving disease-modifying activity in OA.

METHODS: Primary human articular cartilage and synovial tissue samples from patients with knee OA undergoing total joint replacement and from healthy human subjects were obtained from the National Disease Research Interchange. For in vivo animal studies, a partial medial meniscectomy (PMM) model of knee …

Low-Dose Versus High-Dose Carfilzomib With Dexamethasone (S1304) In Patients With Relapsed-Refractory Multiple Myeloma, Sikander Ailawadhi, Rachael Sexton, Suzanne Lentzsch, Muneer H Abidi, Peter M Voorhees, Adam D Cohen, Eric M Rohren, Stephen Heitner, Kevin Kelly, Niklas J Mackler, David M Baer, Antje Hoering, Brian Durie, Robert Z Orlowski

Faculty, Staff and Students Publications

PURPOSE: Treatment of multiple myeloma has evolved tremendously and optimal utilization of available therapies will ensure maximal patient benefits.

PATIENTS AND METHODS: We report the Southwest Oncology Group randomized phase II trial (S1304) comparing twice weekly low-dose (27 mg/m

RESULTS: Among 143 enrolled patients, of whom 121 were eligible and analyzable, the overall response rate was 42.8%, with no significant difference between the arms (

CONCLUSIONS: This randomized trial did not support a benefit of fixed duration, twice weekly 56 mg/m

Beavercube: Coastal Imaging With Vis/Lwir Cubesats, Paula Do Vale Pereira, Madeline Garcia, Madeleine Schroeder, Humberto Caldelas, Charles Lindsay, Alex Choi, Kaila Pfrang, Amelia Gagnon, Alex Meredith, Patrick Mckeen, Jim Clark, Thomas J. Murphy, Sheila Baber, Sabrina Khan, Alex Miller, Gustavo Velez, Matthew Campbell, Jacob Coray, Jim Koldada, Tina Tran, Sam Austin, Alison Louthain, Tesla Wells, Mohammad Kabir, Ethan Sit, Christian Haughwout, Kerri Cahoy

Small Satellite Conference

BeaverCube is a student-built 3U CubeSat that has two main objectives: one science objective and one technology objective. The science goal of BeaverCube is to demonstrate that it is possible to develop and apply platforms that can leverage statistical relationships between temperature and co-varying bio-optical properties, such as light absorption by colored dissolved organic matter. The technology goal of BeaverCube is to demonstrate electrospray propulsion for CubeSats, enabling more coordinated and targeted science missions among multiple spacecraft.

The science objective for BeaverCube involves measuring temperature and color, which are key oceanographic properties, through a low-cost platform. Temperature and salinity are …

What’S Next After Industry Disruption By Cubesats? – Industry Disruption By Open Source, Anita Bernie, John Paffett

Small Satellite Conference

A decade ago, CubeSats featured almost exclusively in the academic domain only. The same can be said today for Open Source satellites.

In the same way that CubeSats and the associated development mindset started in the academic community and are now embraced by commercial, civil and defence communities, the goal of the Open Source Satellite Programme is to initiate a similar outcome for open source satellite mission architectures by developing a design that is freely available for all to use.

KISPE’s goal is to build a community of open-source contributors, collaborators and beneficiaries, including those from CubeSat and SmallSat teams …

Reflections Of The Angiotensin Receptor Blocker Recall By The Fda And Repercussions On Healthcare, Michael Gillette, Addison Taylor, Djenita Butulija, Himabindu Kadiyala, Hani Jneid

Faculty, Staff and Students Publications

PURPOSE: Beginning in July of 2018, the FDA issued a voluntary recall regarding the presence of a contaminant found in the manufacturing of valsartan. What would ensue has become a largely unprecedented sequence of alarming events since the FDA began reporting public recalls, withdrawals and safety alerts on their website in 2016. Since then, the United States has been significantly impacted by drug recalls affecting angiotensin receptor blockers. This report arms clinicians with additional guidance and provides a framework for responding appropriately to future similar incidents and includes an overview of the angiotensin receptor blockers, and their effects and safety …

The Nasa Cubesat Missions Flying On Artemis-1, Dawn M. Mcintosh, John D. Baker, Joseph A. Matus

Small Satellite Conference

In 2021, the Space Launch Services (SLS) Artemis-1 mission will carry thirteen 6U CubeSats into deep space. Three of those payloads are NASA missions performing a variety of unique deep-space science experiments. The three NASA CubeSat missions are BioSentinel, Lunar Flashlight and NEAScout. The BioSentinel mission will measure deep-space radiation effects on DNA using yeast organisms. It is a six-month mission in a heliocentric orbit. BioSentinel was designed, built, tested and operated out of NASA Ames Research Center. Lunar Flashlight’s mission is to look for surface water ice in the permanently shadowed regions near the south pole of the Moon …

Vt Thicksat: A Scalable Chassis In The Thinsat Program, Derick Whited, Minzhen Du, Robert Engebretson, Gustavo Gargioni, Kevin Shinpaugh, Jonathan Black

Small Satellite Conference

This paper presents a scalable design of a small satellite chassis for the ThinSat Program. This versatile chassis will fly on Virginia Tech’s ThinSat mission in 2020, VT ThickSat. By incrementing the volume of the satellite chassis, students from Virginia Tech introduce a unique capability that combines the ThinSat’s rapid deployment with upscaled payload sizes. The scalable solution reflects an expansion of the original ThinSat 1T chassis up to nearly that of a1U CubeSat. Enabling the accommodation of larger educational and research payloads using the same proven flight hardware as the 1T option, a family of alternative vehicles for institutions …

Bammsat-On-Bexus: A Technology And Operation Demonstration Of A Biocubesat Platform On A Stratospheric Balloon Flight Educational Program, Aqeel Shamsul, Giovanni Sinclair, Adrien Bolliand, Amin Chabi, Miguel Martinez De Bujo, Mateusz Zalasiewicz, David C. Cullen, Mike Cooke, T. Etheridge

Small Satellite Conference

This paper reports the current use of the REXUS/BEXUS educational program. The program allows university students across Europe to carry out scientific and technology experiments on research sounding rockets and balloons. BAMMsat-on-BEXUS (BoB) is an experiment from Cranfield University and University of Exeter performing a technology and operation demonstration of a bioCubeSat on a stratospheric balloon at an altitude of ~30km above the ground. BEXUS stands for Balloon Experiments for University Students and is realized under an agreement between the German Aerospace Centre (DLR), Swedish National Space Agency (SNSA), European Space Agency (ESA), and EuroLaunch. The term bioCubeSat could be …

Dementia Prevention, Intervention, And Care: 2020 Report Of The Lancet Commission, G Livingston, J Huntley, A Sommerlad, Et Al

Peninsula Medical School

The number of older people, including those living with dementia, is rising, as younger age mortality declines. However, the age-specific incidence of dementia has fallen in many countries, probably because of improvements in education, nutrition, health care, and lifestyle changes. Overall, a growing body of evidence supports the nine potentially modifiable risk factors for dementia modelled by the 2017 Lancet Commission on dementia prevention, intervention, and care: less education, hypertension, hearing impairment, smoking, obesity, depression, physical inactivity, diabetes, and low social contact. We now add three more risk factors for dementia with newer, convincing evidence. These factors are excessive alcohol …

Investigation Of Strength And Fatigue Life Of Rubber Asphalt Mixture, Jiang Yuan, Songtao Lv, Xinghai Peng, Lingyun You, Milkos Borges Cabrera

Michigan Tech Publications, Part 1

Strength and fatigue life are essential parameters of pavement structure design. To accurately determine the pavement structure resistance of rubber asphalt mixture, the strength tests at various temperatures, loading rate, and fatigue tests at different stress levels were conducted in this research. Based on the proposed experiments, the change law of rubber asphalt mixture strength with different temperatures and loading rates was revealed. The phenomenological fatigue equation of rubber asphalt mixture was established. The genetic algorithm optimized backpropagation neural network (GA-BPNN) is highly reliable for optimizing production processes in civil engineering, and it has a remarkable application effect. A GA-BPNN …

De Novo Variants Of Nr4a2 Are Associated With Neurodevelopmental Disorder And Epilepsy, Sakshi Singh, Rachel Slaugh, Jorge Granadillo, Et Al.

2020-Current year OA Pubs

PURPOSE: This study characterizes the clinical and genetic features of nine unrelated patients with de novo variants in the NR4A2 gene.

METHODS: Variants were identified and de novo origins were confirmed through trio exome sequencing in all but one patient. Targeted RNA sequencing was performed for one variant to confirm its splicing effect. Independent discoveries were shared through GeneMatcher.

RESULTS: Missense and loss-of-function variants in NR4A2 were identified in patients from eight unrelated families. One patient carried a larger deletion including adjacent genes. The cases presented with developmental delay, hypotonia (six cases), and epilepsy (six cases). De novo status was …

Lower Rates Of Heart Failure And All-Cause Hospitalizations During Pulmonary Artery Pressure-Guided Therapy For Ambulatory Heart Failure: One-Year Outcomes From The Cardiomems Post-Approval Study., David M Shavelle, Akshay S Desai, William T Abraham, Robert C Bourge, Nirav Raval, Lisa D Rathman, J Thomas Heywood, Rita A Jermyn, Jamie Pelzel, Orvar T Jonsson, Maria Rosa Costanzo, John D Henderson, Marie-Elena Brett, Philip B Adamson, Lynne W Stevenson, Cardiomems Post-Approval Study Investigators, Jacob Abraham (Cardiomems Post-Approval Study Investigator)

Articles, Abstracts, and Reports

BACKGROUND: Ambulatory hemodynamic monitoring with an implantable pulmonary artery (PA) sensor is approved for patients with New York Heart Association Class III heart failure (HF) and a prior HF hospitalization (HFH) within 12 months. The objective of this study was to assess the efficacy and safety of PA pressure-guided therapy in routine clinical practice with special focus on subgroups defined by sex, race, and ejection fraction.

METHODS: This multi-center, prospective, open-label, observational, single-arm trial of 1200 patients across 104 centers within the United States with New York Heart Association class III HF and a prior HFH within 12 months evaluated …

Tumor Organoids To Study Gastroesophageal Cancer: A Primer, Ramon U Jin, Jason C Mills

2020-Current year OA Pubs

Gastroesophageal cancers are leading causes of cancer death. Our attempts at adopting molecularly based treatment approaches have been slow and ineffective even though we begin to identify specific targetable gene mutations and pathways. It is clear that we should no longer treat all gastroesophageal cancers as a homogeneous disease, which is what we do when we use non-specific chemotherapy. However, we currently cannot monitor successful gene/pathway targeting, nor understand how/when tumors develop resistance, nor predict which patients will derive maximal benefit. To improve outcomes, we must precisely detail the heterogeneity of these tumors to then individualize cancer therapy as well …