Digital Commons Network^™

Dysregulated Interferon Response Underlying Severe Covid-19, Leann Lopez, Peter C. Sang, Yun Tian, Yongming Sang

Agricultural and Environmental Sciences Faculty Research

Innate immune interferons (IFNs), including type I and III IFNs, constitute critical antiviral mechanisms. Recent studies reveal that IFN dysregulation is key to determine COVID-19 pathogenesis. Effective IFN stimulation or prophylactic administration of IFNs at the early stage prior to severe COVID-19 may elicit an autonomous antiviral state, restrict the virus infection, and prevent COVID-19 progression. Inborn genetic flaws and autoreactive antibodies that block IFN response have been significantly associated with about 14% of patients with life-threatening COVID-19 pneumonia. In most severe COVID-19 patients without genetic errors in IFN-relevant gene loci, IFN dysregulation is progressively worsened and associated with the …

Southern Adventist University Commencement Program December 13, 2020, Southern Adventist University

Commencement Programs

Program for Southern Adventist University December graduation. The commencement service took place on December 13, 2020.

Newly Generated Atractylon Derivatives In Processed Rhizomes Of Atractylodes Macrocephala Koidz, Chunmei Zhai, Jianping Zhao, Amar G. Chittiboyina, Yonghai Meng, Mei Wang, Ikhlas A. Khan

Faculty and Student Publications

Thermally processed rhizomes of Atractylodes macrocephala (RAM) have a long history of use in traditional Chinese medicine (TCM) for treating various disorders, and have been an integral part of various traditional drugs and healthcare products. In TCM, herbal medicines are, in most cases, uniquely processed. Although it is thought that processing can alter the properties of herbal medicines so as to achieve desired functions, increase potency, and/or reduce side effects, the underlying chemical changes remain unclear for most thermally processed Chinese herbal medicines. In an attempt to shed some light on the scientific rationale behind the processes involved in traditional …

Toll-Like Receptor 7 Is Required For Lacrimal Gland Autoimmunity And Type 1 Diabetes Development In Male Nonobese Diabetic Mice., Ivy L Debreceni, Michael S Chimenti, David V. Serreze, Aron M Geurts, Yi-Guang Chen, Scott M Lieberman

Faculty Research 2020

Sjögren syndrome (SS) is an immunologically complex, chronic autoimmune disease targeting lacrimal and salivary glands. Nonobese diabetic (NOD) mice spontaneously develop inflammation of lacrimal and salivary glands with histopathological features similar to SS in humans including focal lymphocytic infiltrates in the affected glands. The innate immune signals driving lymphocytic infiltration of these glands are not well-defined. Here we evaluate the role of Toll-like receptor (TLR) 7 in the development of SS-like manifestations in NOD mice. We created a Tlr7 knockout NOD mouse strain and performed histological and gene expression studies to characterize the effects of TLR7 on autoimmunity development. TLR7 …

Possible Transmission Flow Of Sars-Cov-2 Based On Ace2 Features, Sk Sarif Hassan, Shinjini Ghosh, Diksha Attrish, Pabitra Pal Choudhury, Alaa A A Aljabali, Bruce D Uhal, Kenneth Lundstrom, Nima Rezaei, Vladimir N Uversky, Murat Seyran, Damiano Pizzol, Parise Adadi, Antonio Soares, Tarek Mohamed Abd El-Aziz, Ramesh Kandimalla, Murtaza M Tambuwala, Gajendra Kumar Azad, Samendra P Sherchan, Wagner Baetas-Da-Cruz, Kazuo Takayama, Ángel Serrano-Aroca, Gaurav Chauhan, Giorgio Palu, Adam M Brufsky

All publications

Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22-42, aa 79-84, and aa 330-393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the …

Creating Trauma Sensitive Classroom In The Early Childhood Setting, Janelle Elke

Dissertations, Theses, and Projects

The purpose of this study is to ensure that our early childhood classrooms are trauma sensitive for our students that have been exposed or are experiencing trauma. Roughly 26 percent of children in the United States witness or experience a trauma before the age of 4( Briggs- Gowan et al.2010). The study was conducted in three different phases. In the first phase, data was collected on what strategies are presently implemented for students who have been exposed to trauma. In the second phase, strategies, techniques and tools were introduced to help during stressful situations that happened during class. In the …

Role Of Nutraceuticals In Covid-19 Mediated Liver Dysfunction, Mohammed Sikander, Shabnam Malik, Anyssa Rodriguez, Murali M. Yallapu, Acharan S. Narula, Sanjaya K. Satapathy, Vijian Dhevan, Subhash C. Chauhan, Meena Jaggi

School of Medicine Publications

COVID-19 is known as one of the deadliest pandemics of the century. The rapid spread of this deadly virus at incredible speed has stunned the planet and poses a challenge to global scientific and medical communities. Patients with COVID-19 are at an increased risk of co-morbidities associated with liver dysfunction and injury. Moreover, hepatotoxicity induced by antiviral therapy is gaining importance and is an area of great concern. Currently, alternatives therapies are being sought to mitigate hepatic damage, and there has been growing interest in the research on bioactive phytochemical agents (nutraceuticals) due to their versatility in health benefits reported …

Protocol For The Prognosticating Delirium Recovery Outcomes Using Wakefulness And Sleep Electroencephalography (P-Drows-E) Study: A Prospective Observational Study Of Delirium In Elderly Cardiac Surgical Patients, S Kendall Smith, Thomas Nguyen, Alyssa K Labonte, Mohammadmehdi Kafashan, Orlandrea Hyche, Christian S Guay, Elizabeth Wilson, Courtney W Chan, Anhthi Luong, L Brian Hickman, Bradley A Fritz, Daniel Emmert, Thomas J Graetz, Spencer J Melby, Brendan P Lucey, Yo-El S Ju, Troy S Wildes, Michael S Avidan, Ben J A Palanca

Open Access Publications

INTRODUCTION: Delirium is a potentially preventable disorder characterised by acute disturbances in attention and cognition with fluctuating severity. Postoperative delirium is associated with prolonged intensive care unit and hospital stay, cognitive decline and mortality. The development of biomarkers for tracking delirium could potentially aid in the early detection, mitigation and assessment of response to interventions. Because sleep disruption has been posited as a contributor to the development of this syndrome, expression of abnormal electroencephalography (EEG) patterns during sleep and wakefulness may be informative. Here we hypothesise that abnormal EEG patterns of sleep and wakefulness may serve as predictive and diagnostic …

Yap And Taz Maintain Prox1 Expression In The Developing Lymphatic And Lymphovenous Valves In Response To Vegf-C Signaling, Boksik Cha, Yen-Chun Ho, Xin Geng, Md Riaj Mahamud, Lijuan Chen, Yeunhee Kim, Dongwon Choi, Tae Hoon Kim, Gwendalyn J Randolph, Xinwei Cao, Hong Chen, R Sathish Srinivasan

Open Access Publications

Lymphatic vasculature is an integral part of digestive, immune and circulatory systems. The homeobox transcription factor PROX1 is necessary for the development of lymphatic vessels, lymphatic valves (LVs) and lymphovenous valves (LVVs). We and others previously reported a feedback loop between PROX1 and vascular endothelial growth factor-C (VEGF-C) signaling. PROX1 promotes the expression of the VEGF-C receptor VEGFR3 in lymphatic endothelial cells (LECs). In turn, VEGF-C signaling maintains PROX1 expression in LECs. However, the mechanisms of PROX1/VEGF-C feedback loop remain poorly understood. Whether VEGF-C signaling is necessary for LV and LVV development is also unknown. Here, we report for the …

Peningkatan Pertumbuhan Tunas Kunyit Putih Pada Perbanyakan In Vitro Melalui Aplikasi Berbagai Jenis Dan Konsentrasi Sitokinin, Murgayanti, Fatilla Nur Ramadhanti, Sumadi

Jurnal Kultivasi

Kunyit putih (Kaempferia rotunda L.) merupakan tanaman obat yang bermanfaat dan perlu dibudidayakan lebih luas, namun terkendala oleh penyediaan bibit bermutu yang terbatas sehingga menjadi langka. Perbanyakan tanaman dengan cara konvensional memerlukan bibit bermutu dalam jumlah dan waktu yang lama, sedangkan ketersediaan benih masih terbatas. Perbanyakan secara in vitro dapat mengatasi kelangkaan bibit kunyit putih yang bermutu tinggi dalam jumlah besar dan bebas patogen. Ketersediaan bibit unggul yang dihasilkan secara in vitro bergantung pada jenis dan konsentrasi sitokinin yang ditambahkan pada media kultur. Tujuan penelitian adalah untuk menentukan jenis dan konsentrasi sitokinin yang paling baik pengaruhnya terhadap pertumbuhan tunas kunyit …

Pertumbuhan Dan Hasil Benih Kentang G0 Kultivar Medians Pada Berbagai Komposisi Media Tanam Dan Interval Pemberian Air Di Dataran Medium, Jajang Sauman Hamdani, Sumadi, Kusumiyati, Haifa Ruwaidah

Jurnal Kultivasi

Benih merupakan kunci sukses budidaya kentang. Salah satu faktor yang mempengaruhi dan menjadi kendala produksi kentang di Indonesia adalah ketersediaan benih kentang yang memiliki kualitas dan kuantitas baik serta belum memenuhi kebutuhan permintaan benih petani kentang. Permasalahan produksi benih kentang generasi ke-0 (G0) adalah rendahnya jumlah ubi benih yang dihasilkan. Percobaan ini bertujuan untuk mengetahui interaksi antara komposisi media tanam dengan interval pemberian air terhadap produksi benih kentang G0 di dataran medium. Percobaan dilaksanakan di Kebun Percobaan, Fakultas Pertanian, Universitas Padjadjaran, Kampus Jatinangor. Rancangan percobaan yang digunakan yaitu Split Plot. Petak utama adalah komposisi media tanam yang terdiri dari campuran …

Multiplikasi Cepat Tunas Tiga Aksesi Stevia Secara In Vitro, Suseno Amien, Dion Nugraha Aji, Tuti Mamluatul

Jurnal Kultivasi

Stevia (Stevia rebaudiana (Bertoni)) telah menjadi pelengkap untuk memenuhi kebutuhan bahan pemanis yang terus meningkat di Indonesia. Jumlah varietas unggul Stevia di Indonesia masih terbatas. Keterbatasan ini perlu diimbangi dengan metode perbanyakan yang cepat. Multiplikasi tunas merupakan salah satu metode dalam kultur jaringan yang dapat dimanfaatkan untuk perbanyakan cepat bibit Stevia. Penelitian ini bertujuan untuk memperoleh respon aksesi-aksesi stevia terhadap multiplikasi tunas stevia pada komposisi media berbeda. Penelitian telah dilaksanakan dalam dua tahap percobaan. Penelitian menggunakan Rancangan Acak Lengkap (RAL) faktorial yang masing-masing terdiri atas dua faktor. Percobaan pertama terdiri dari dua faktor. Faktor pertama adalah tiga aksesi stevia yakni …

Citation Analysis Of Doctoral Theses In Library And Information Science Submitted To Manipur University During 1989-2017, Jaba Moni Das, Dr. Dipen Deka Assistant Professor

Library Philosophy and Practice (e-journal)

Abstract

The present study applies the citation analysis method to analyze Library and Information Science (LIS) doctoral theses submitted to Manipur University during 1989-2017. A total of 2,725 citations appended to 27 LIS doctoral theses examined for bibliographic forms, authorship pattern, and their collaboration level, chronological-wise distribution, the applicability of Bradford's law, rank-wise list, core journal list, country-wise list. The study finds that journals are the most cited resources, followed by books. Single-authored works are found dominant in both journal and book citations. The country-wise distribution of journals reveals that 412 citations (38.52%) were from India, followed by the UK …

A Citation Analysis Of Chemistry Publications By Faculty Members And Research Scholars At University Of Mysore And Karnatak University, Kodandarama ., Chandrashekara M

Library Philosophy and Practice (e-journal)

Purpose-The study aims to analyse the resources used in the citations of 1355 research publications of University of Mysore and Karnatak University in the field of chemistry and prepares the core journal list and prolific authors. For any research and academic institutional libraries, books and journals are considered as key resources. As the resources are more and diverse, collection building is a tough task for librarians. Citation analysis is one of the best methods to list the most used resources by the users. Hence, the paper highlights the extent of use of different sources in the research publications of chemistry. …

Paddock To Paddock Pasture Yield Variation On Dairy Farms In The Waikato Region Of New Zealand, Alvaro J. Romera, C. E. F. Clark

IGC Proceedings (1977-2023)

No abstract provided.

In‐Herd Diversity Of Lifetime Performances: A Key For The Sustainability Of Livestock Farming System Based On Grassland, Laurence Puillet, D. Sauvant, M. Tichit

IGC Proceedings (1977-2023)

No abstract provided.

The Feeding Scheme Of Extensive Animal Production Systems In Montado, José Mira Potes

IGC Proceedings (1977-2023)

No abstract provided.

Rheological Effect During Swelling Of Polymer Membranes In Aqueous Solutions With Different Dithyremic Content, Yulchi T. Juraev, Leonard M. Sabirov, Nikolay F. Bunkin, Valeriy A. Kozlov

Scientific Journal of Samarkand University

It was shown that the swelling of the initially hydrophobic Nafion plate in ordinary water (157 ppm deuterium content) and in deuterium-depleted water (1 ppm deuterium content) in a limited volume cell occurs differently. It turned out that small changes in the deuterium content in water lead to significant differences in the dynamics of swelling of the polymer membrane. For a 175-micron thick Nafion plate, this effect is most pronounced when the distance between the windows is L = 200 microns.

Raman Scattering Spectra Of Α-Alanine Molecular Complexes, Hakim Hushvaktov

Scientific Journal of Samarkand University

The article presents the results of studying the complexity of the Raman spectra of a-alanine in the crystalline state. It has been shown by ab initio calculations that the change in the Raman spectra is explained by the formation of several types of hydrogen bonds. In Raman spectra, the presence of a hydrogen bond between molecules is manifested in the form of asymmetry and splitting of vibrational bands.

Finding All ∈-Good Arms In Stochastic Bandits, Blake Mason, Lalit Jain, Ardhendu S. Tripathy, Robert Nowak

Computer Science Faculty Research & Creative Works

The pure-exploration problem in stochastic multi-armed bandits aims to find one or more arms with the largest (or near largest) means. Examples include finding an ∈-good arm, best-arm identification, top-k arm identification, and finding all arms with means above a specified threshold. However, the problem of finding all ∈-good arms has been overlooked in past work, although arguably this may be the most natural objective in many applications. For example, a virologist may conduct preliminary laboratory experiments on a large candidate set of treatments and move all ∈-good treatments into more expensive clinical trials. Since the ultimate clinical efficacy is …

2020 Fall - Commencement Program, Office Of The Registrar, East Tennessee State University

ETSU Commencement Ceremonies and Programs

No abstract provided.

Sink Hollow Volume 10

Sink Hollow

This year felt like a thunderstorm. Rain pelting down on us so hard it burns. Lightning strikes so stark we have to close our eyes. Thunder rumbling so ominously we feel it deep in our bones. So many things we hold dear have been lost in this storm.

But something we have found is the human ability to feel a raw and powerful pain. We are intrinsically bound to each other, to nature, and to this world by the pain we feel. A pain so powerful and deep you feel it is sucking you under and drowning you.

The pieces …

Wildlife Trade And Covid-19: Towards A Criminology Of Anthropogenic Pathogen Spillover, Piers Beirne Phd

Department of Criminology

The general remit of this paper is the role of wildlife trade in pathogen spillover. Its underlying assumption is that, so far from being the exclusive domain of the life sciences, the study of pathogen spillover will be greatly enhanced by multi-perspectival approaches, including One Health and those employed here, namely, non-speciesist green criminology and critical animal studies. The paper moves from discussions of zoonosis, anthroponosis and wildlife trade to the emergence of COVID-19 in Wuhan, China. The paper recommends the abolition of all wildlife trade and the reclamation of wildlife habitat and broaches discussion of the extension of legal …

An Invasive Species As A Threat To Native Biodiversity: Larval Competition Between Native Anurans And An Invasive Treefrog, Mckenzie Wasley

Electronic Theses and Dissertations

Cuban Treefrogs (Osteopilus septentrionalis) are established in Florida and Louisiana and have invasive potential further westward, possibly impacting native anurans at multiple life stages. In anurans, competition at the larval stage can decrease adult fitness through slower development and smaller size at metamorphosis, ultimately decreasing recruitment rates. To examine the potential impacts of O. septentrionalis at the larval life-history stage, I quantified activity levels and growth of their tadpoles and those of two anurans native to eastern Texas: Green Treefrogs (Hyla cinerea) and Gulf Coast Toads (Incilius nebulifer). Tadpoles of the three species were …

Dissecting Regulation Mechanism Of Interdomain Electron Transfer In Nitric Oxide Synthases, Huayu Zheng

Chemistry and Chemical Biology ETDs

Nitric oxide (NO) is generated by one of the three isoforms of mammalian NO synthases (NOSs), neuronal, endothelial and inducible NOS (nNOS, eNOS, and iNOS, respectively). Dysregulated NOS is implicated in pathologies of numerous severe diseases including Alzheimer and Parkinson’s diseases. Molecular mechanisms of NOS regulation, once fully understood, are potentially key targets for development of selective new pharmaceuticals for treating these diseases that currently lack effective treatments.

Despite recent developments, there are significant gaps in current understanding of the regulation mechanism of the FMN-heme interdomain electron transfer (IET), an essential step in NOS, by its key regulators such as …

Winter Commencement, 2020, Marshall University

Marshall University Commencement

Program for the one hundred and eighty-third commencement at Marshall University.

Experienced Esl Teachers' Attitudes Towards Using Phonetic Symbols In Teaching English Pronunciation To Adult Esl Students, Oxana Kodirova

Theses and Dissertations

Different opinions exist about the use of phonetic alphabet symbols in teaching English pronunciation to second language learners. Some authors and researchers believe phonetic symbols can benefit students in many ways; others consider this tool hardly recommendable. However, little empirical research has been done to find out what ESL teachers think about the use of this linguistic tool. Thus, via an online survey this study sought to identify ESL teachers' attitudes towards the use of phonetic symbols in teaching ESL pronunciation. A total of 120 teachers took the survey and most of them were experienced in teaching pronunciation to adult …

Prenatal Alcohol Exposure Alters Transcriptional Expression Of Stress And Tlr4-Related Immune Signaling Factors In The Brain Following Early Life Stress, Chaselyn D. Ruffaner-Hanson

Biomedical Sciences ETDs

Background: Depression and anxiety disorders, believed to be caused by stress-related neuropeptides and pro-inflammatory molecules in the brain, are prevalent comorbidities of fetal alcohol spectrum disorders (FASD).

Methods: Brain tissue was collected following a 4-hour maternal separation stress during the early postnatal period, postnatal days 10 and 12, from mice subjected to 1^st and 2^nd trimester prenatal alcohol exposure (PAE).

Hypothesis: We hypothesized that PAE leads to glucocorticoid receptor insensitivity, stress molecule overexpression, and potentiated toll-like receptor 4 (TLR4) pathway inflammatory responses in the brain following early life stress.

Results: PAE and stress increased mRNA expression of TLR4 …

Adult Hippocampal Neurogenesis As A Potential Therapeutic Target In Fetal Alcohol Spectrum Disorders, Kymberly Cheyanne Gustus

Biomedical Sciences ETDs

This dissertation aims to determine if adult hippocampal neurogenesis is a potential therapeutic target in Fetal Alcohol Spectrum Disorders (FASDs). Adult hippocampal neurogenesis plays important and unique roles in certain aspects of learning, memory, and mood (Anacker & Hen, 2017). Individuals with FASDs often demonstrate dysregulation in these arenas (Lewis et al., 2015; Temple, Cook, Unsworth, Rajani, & Mela, 2019). Previous work in our lab using a mouse model of prenatal alcohol exposure demonstrated impairment in enrichment-mediated adult hippocampal neurogenesis (Irene Y. Choi, Andrea M. Allan, & Lee Anna Cunningham, 2005; K. Kajimoto, A. Allan, & L. A. Cunningham, 2013). …

The Covid-19 Pandemic: An Analysis Of Its Inequitable Impacts Towards The Black Population With Recommendations To Dismantling Institutional Racism, Elena Peterson

Master's Projects and Capstones

Due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the 2020 coronavirus disease pandemic uncovered health inequities throughout the United States. This paper explores institutional racism as the reasoning behind these health inequities. A discussion of the United States’ failure to implement preventative precautions once notified initially of the coronavirus is featured. Events that took place after the recognition of the coronavirus, such as the economic impacts and passed legislation, are highlighted as well. An overview of the Trump Administration’s lack of focus towards vulnerable populations, which includes the Black communities, is included. Also, there are highlights on …