Digital Commons Network^™

Molecular Profiling Of Melanoma Brain Metastases Compared To Primary Cutaneous Melanoma And To Extracranial Metastases., Gino K In, Kelsey Poorman, Michelle Saul, Steven O'Day, Jeffrey M Farma, Anthony J Olszanski, Michael S Gordon, Jacob S Thomas, Burton Eisenberg, Lawrence Flaherty, Amy Weise, Steven Daveluy, Geoffrey Gibney, Michael B Atkins, Ari Vanderwalde

Articles, Abstracts, and Reports

BACKGROUND: Brain metastases are a significant cause of mortality and morbidity for patients with melanoma. We hypothesize that the development of brain metastases may be explained by molecular heterogeneity between primary cutaneous melanoma (PCM) or extracranial (ECM) and brain (MBM) melanoma metastases.

MATERIALS AND METHODS: We compared next-generation sequencing, tumor mutational burden (TMB), and immunohistochemical staining for PD-L1 expression, among 132 MBM, 745 PCM, and 1190 ECM.

RESULTS: The most common genetic alterations among MBM included: BRAF (52.4%), NRAS (26.6%), CDKN2A (23.3%), NF1 (18.9%), TP53 (18%), ARID2 (13.8%), SETD2 (11.9%), and PBRM1 (7.5%). Four genes were found with higher frequency …

Reducing Emotional Distress For Childhood Hypoglycemia In Parents (Redchip): Protocol For A Randomized Clinical Trial To Test A Video-Based Telehealth Intervention., Susana R. Patton, Andrew Mcconville, Arwen M. Marker, Alexandra D. Monzon, Kimberly A A. Driscoll, Mark A. Clements

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Despite the introduction of new insulin analogs, insulin pumps, and continuous glucose monitoring (CGM), young children with type 1 diabetes mellitus (T1D) remain vulnerable to episodes of hypoglycemia because of their unpredictable eating and activity patterns and high degree of insulin sensitivity. Caregivers and young children living with T1D learn to fear hypoglycemia because it is uncomfortable, unpredictable, and dangerous. Up to 60% of caregivers of young children with T1D report moderate to severe levels of fear of hypoglycemia, and caregiver fear of hypoglycemia relates to lower quality of life for families and suboptimal child glycemic control. Yet, until …

Obesity In Thurston County Washington, Sheaunna Guary

Selected Social Change Portfolios in Prevention, Intervention, and Consultation

Thurston County Washington is experiencing a steady increase in the rates of adult obesity within our community. Obesity can have a negative impact on the mental, physical, and financial health of individuals and the county at large (Pul & Suh, 2015). As such, the author proposes addressing this community issue through a social change project that contains both preventative measures as well as postvention efforts to address and decrease rates of obesity in Thurston County Washington.

High Ethanol Concentration (77 G/L) Of Industrial Hemp Biomass Achieved Through Optimizing The Relationship Between Ethanol Yield/Concentration And Solid Loading, Jikai Zhao, Youjie Xu, Weiqun Wang, Jason Griffin, Donghai Wang

School of Earth, Environmental, & Marine Sciences Faculty Publications

In this study, the relationships between ethanol yield/concentration and solid loading (6–21%) were investigated to enhance ethanol titer and avoid a random choice of solid loading for simultaneous saccharification and fermentation (SSF). Alkali-pretreated hemp biomass was used for SSF in four scenarios including Case I: 30 filter paper unit (FPU)-cellulase and 140 fungal xylanase unit (FXU)-hemicellulase/g-solid; Case II: 40 FPU-cellulase and 140 FXU-hemicellulase/g-solid; Case III: 30 FPU-cellulase and 140 FXU-hemicellulase/g-solid with 1% Tween80; and Case IV: 30 FPU-cellulase and 140 FXU-hemicellulase/g-solid with particle size reduction (R2 = 0.76–0.93) and quadratic (R2 = 0.96–0.99) correlation with solid loading (6–21%), …

Host Plant Defense Produces Species-Specific Alterations To Flight Muscle Protein Structure And Flight-Related Fitness Traits Of Two Armyworms, Scott L. Portman, Gary W. Felton, Rupesh R. Kariyat, James H. Marden

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Insects manifest phenotypic plasticity in their development and behavior in response to plant defenses, via molecular mechanisms that produce tissue-specific changes. Phenotypic changes might vary between species that differ in their preferred hosts and these effects could extend beyond larval stages. To test this,we manipulated the diet of southern armyworm(SAW; Spodoptera eridania) and fall armyworm (FAW; Spodoptera frugiperda) using a tomato mutant for jasmonic acid plant defense pathway (def1), and wild-type plants, and then quantified gene expression of Troponin t (Tnt) and flightmusclemetabolismof the adult insects. Differences in Tnt spliceform ratios in insect flight muscles correlate with changes to flight …

Characteristics Of A River Otter (Lontra Canadensis) Maternal Den In The Central Platte River Valley, Ne, Jenna M. Malzahn, Andrew J. Caven, Joshua D. Wiese

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

River otters (Lontra canadensis) encompass a broad geographic range including coastal, riverine, and lacustrine systems. However, knowledge of reproductive behavior and structural den characteristics remain relatively few in the literature, particularly in the Great Plains. Distinctions between the terms “den”, “den site”, “natal den”, and “maternal den” are often ambiguous, obscuring our understanding of river otter’s young-rearing behavior. We used observations and descriptions regarding a single maternal den site and a broad reading of the mustelid literature to propose a more standardized maternal den definition for river otters and specify hypotheses for future research. From 25 April to …

An Interactive Compositional Tool Using The Electroencephalogram, R Horrell

School of Art, Design and Architecture

This paper proposes an interactive approach to aid the compositional process using the brain-computer music interface (BCMI). In particular, the system developed in this paper focuses on creating an interactive compositional process inclusive to non-musicians and those with motor disabilities, in addition to providing a new method of composing. This paper references and compares two BCMI systems that have been developed for compositional purposes and draws upon these ideas to form the proposed system in this paper. Such system would aid the compositional process based on note velocity, chords and key changes.

A Decade Of Marine Mammal Acoustical Presence And Habitat Preference In The Bering Sea, Kerri D. Seger, Jennifer L. Miksis-Olds

Center for Coastal and Ocean Mapping

As Arctic seas rapidly change with increased ocean temperatures and decreased sea ice extent, traditional Arctic marine mammal distributions may be altered, and typically temperate marine mammal species may shift poleward. Extant and seasonal odontocete species on the continental shelves of the Bering and Chukchi Seas include killer whales (Orcinus orca), sperm whales (Physeter microcephalus), beluga whales (Delphiapterus leucas), harbor porpoises (Phocoena phocoena), and Dall’s porpoises (Phocoenoides dalli). Newly documented, typically temperate odontocete species include Risso’s dolphins (Grampus griseus) and Pacific white-sided dolphins (Lagenorhynchus obliquidens). Until recently, recording constraints limited sampling rates, preventing the acoustic detection of many of these …

"Dream With Me" Juwel Howard Voice Recital, Andrews University

Student Degree Recitals 2019-2020

Juwel Howard, soprano, presents her senior recital "Dream with Me", accompanied by Emily Jurek, piano. Works by Bernstein, Verdi, Mozart, and others.

Understanding Of Metals Dysregulation In Patients With Systolic And Diastolic Dysfunction In Ischemic Heart Disease, Noman Khan, Satwat Hashmi, Amna Jabbar Siddiqui, Sabiha Farooq, Shahid Ahmed Sami, Nageeb Basir, Syeda Saira Bokhari, Hasanat Sharif, Sanaullah Junejo, Hesham R. El-Seedi, Syed Ghulam Musharraf

Department of Biological & Biomedical Sciences

Ischemic heart disease (IHD) is the leading cause of death and chronic disability in the world. IHD affects both the systolic and diastolic function of the heart which progressively leads to heart failure; a structural and functional impairment of filling or ejection of blood from the heart. In this study, the progression of systolic and diastolic dysfunction characterized according to their echocardiographic parameters including left ventricular ejection fraction (EF), grades of diastolic dysfunction and ratio between early mitral inflow velocity and mitral annular early diastolic velocity (E/e'), were correlated with differential regulation of various metals in patients sera samples (n …

Wireworms, Ryan Davis, Jay B. Karren, Alan H. Roe

All Current Publications

Wireworms are the larvae (immatures) of click beetles. Adults are elongate, slender, hardshelled beetles that take their name from their habit of flipping into the air (sometimes with an audible clicking sound) when they are placed on their backs. This fact sheet reviews the management of wireworms.

Public Health Violence Prevention: Supporting Law Enforcement, Kira Swensen, Gabriela Murza, Sandra H. Sulzer, Maren Wright Voss

All Current Publications

As frustrations over inequalities in policing and law enforcement continue despite attempted reforms (Beckett, 2016), many are asking for a more effective approach. A 2018 issue statement from the American Public Health Association (2018) highlights that violence is a public health issue that will not go away without the influence of a public health approach. The integrated biological-psychological-social model of health recognizes the complexity in the ways individuals are influenced by their situations, with violence as the unfortunate result of the wrong mix of circumstances. The public health approach to violence focuses on prevention as part of the solution. This …

Racial Differences In Life Expectancy Among Shelby County, Tennessee Residents, Sarah Ashley Nicole Collins

Electronic Theses and Dissertations Archive

Life expectancy is a key measure in population health. Although there have been significant gains in the past decades, deep disparities still persist along racial lines. The aim of this paper is to analyze the disparate life chances of racial and ethnic minorities within Shelby County, Tennessee. OLS regression is used to investigate the association between life expectancy and various sociodemographic variables. The overall life expectancy of Shelby County is years below the national average, and the results of this project find that there are stark differences across census tracts.

The Ubiquitin Ligase Cullin-1 Associates With Chromatin And Regulates Transcription Of Specific C-Myc Target Genes, Melanie A Sweeney, Polina Iakova, Laure Maneix, Fu-Yuan Shih, Hannah E Cho, Ergun Sahin, Andre Catic

Faculty, Staff and Students Publications

Transcription is regulated through a dynamic interplay of DNA-associated proteins, and the composition of gene-regulatory complexes is subject to continuous adjustments. Protein alterations include post-translational modifications and elimination of individual polypeptides. Spatially and temporally controlled protein removal is, therefore, essential for gene regulation and accounts for the short half-life of many transcription factors. The ubiquitin-proteasome system is responsible for site- and target-specific ubiquitination and protein degradation. Specificity of ubiquitination is conferred by ubiquitin ligases. Cullin-RING complexes, the largest family of ligases, require multi-unit assembly around one of seven cullin proteins. To investigate the direct role of cullins in ubiquitination of …

N‐P‐K Balance In A Milk Production System On A C. Nlemfuensis Grassland And A Biomass Bank Of P. Purpureum Ct‐115 Clone, Gustavo Crespo, Idalmis Rodríguez, Omar Martínez

IGC Proceedings (1977-2023)

No abstract provided.

Effect Of Silicon Application On Water Use Efficiency Of Alfalfa Plants, Zhenggang Guo, Huixia Liu, Suomin Wang

IGC Proceedings (1977-2023)

No abstract provided.

Estimation Of Plant N, P And K Contents In The Inner Mongolia Steppe Using Spad Value, Wa Gao, En Wu, N. Ishikawa, Qi Xing, M. Goto

IGC Proceedings (1977-2023)

No abstract provided.

Biological Absorbing Capacity Of Nutrient Elements By Some Temperate Tame Grasses, Zhanchi Du, J. W. Fan, H. P. Zhang

IGC Proceedings (1977-2023)

No abstract provided.

Bibliometric Analysis Of Bioscience Trends Journal (2007-2017): Knowledge Dynamics And Visualization, Anis Fuad, Yuan-Chii Gladys Lee, Chien-Yeh Hsu

Library Philosophy and Practice (e-journal)

BioScience Trends (BST) is a peer-reviewed journal belongs to the International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA) Group of Japan. Despite a decade of existence, no study was performed to measure the bibliometric profile of the journal. The objective of this study was to investigate the bibliometric characteristic of BST. A bibliometric analysis will specifically measure: 1) growth rate of the scientific publications, 2) dynamics of authorship and collaboration pattern; 3) core research themes of articles that have been published, and 4) citation pattern of BST. Bibliographical archives of BST were obtained from the Core Collection …

Addressing The Batch Effect Issue For Lc/Ms Metabolomics Data In Data Preprocessing., Qin Liu, Douglas Walker, Karan Uppal, Zihe Liu, Chunyu Ma, Vilinh Tran, Shuzhao Li, Dean P Jones, Tianwei Yu

Faculty Research 2020

With the growth of metabolomics research, more and more studies are conducted on large numbers of samples. Due to technical limitations of the Liquid Chromatography-Mass Spectrometry (LC/MS) platform, samples often need to be processed in multiple batches. Across different batches, we often observe differences in data characteristics. In this work, we specifically focus on data generated in multiple batches on the same LC/MS machinery. Traditional preprocessing methods treat all samples as a single group. Such practice can result in errors in the alignment of peaks, which cannot be corrected by post hoc application of batch effect correction methods. In this …

Smokejumper Obituary: Chance, Homer Roscoe (Mccall 1944), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Ada News - 08/17/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

The Echo: August 17, 2020, Taylor University

2020-2021 (Volume 108)

Taylor campus comes together again — Different community found within freshman class — Taylor University Class of 2024 — Echoing voices as editors-in-chief — Greg Dyson shares about his heart for hard conversations — ‘Folklore’ shakes up pop music landscape — A new year for new opinions — Crossroads League ready for 2020 season — New 2019 season brings fresh energy to Trojan football

Effect Of Carbon Hybridization In C—F Bond As An Electron Donor In Triel Bonds, Qingqing Yang, Zongqing Chi, Qingzhong Li, Steve Scheiner

Chemistry and Biochemistry Faculty Publications

The ability of the F atom of HC≡CF, H₂C=CHF and H₃CCH₂F to serve as an electron donor to the triel (Tr) atom of TrR₃ in the context of a triel bond is assessed by ab initio calculations. The triel bond formed by C_sp3—F is strongest, as high as 30 kcal/mol, followed by C_sp2—F, and then by C_sp—F whose triel bonds can be as small as 1 kcal/mol. The noncovalent bond strength diminishes in the order Tr = Al > Ga > B, consistent with the intensity of the π-hole …

College Of Liberal Arts Faculty Bylaws - Amended 08/17/20, College Of Liberal Arts Faculty, Rollins College

College of Liberal Arts Bylaws

No abstract provided.

Glucocorticoids, Energy Metabolites, And Immunity Vary Across Allostatic States For Plateau Side-Blotched Lizards (Uta Stansburiana Uniformis) Residing In A Heterogeneous Thermal Environment, Susannah S. French, Spencer B. Hudson

Browse all Datasets

Reptiles rely on thermal heat exchange to achieve body temperatures (Tbody) conducive to maintaining homeostasis. Diurnal changes in the thermal environment are therefore liable to influence allostatic mediation of survival processes (e.g., immunity) during environmental challenges or stressors. However, the extent to which Tbody prompts individual variation in physiology remains largely unexplored in reptiles. Our study tested how circulating energy-mobilizing hormone, energy metabolites, and immunity can vary across basal and stress-induced allostatic states for plateau side-blotched lizards (Uta stansburiana uniformis) residing in a heterogeneous thermal environment. We collected baseline and acute stress blood samples from male lizards to compare changes …

Abundance, Composition And Distribution Of Predatory Gelatinous Zooplankton In The Northern Gulf Of Alaska, Heidi M. Mendoza Islas

Oceanography

Jellyfish are conspicuous yet under-studied components of marine zooplankton communities. Abundance, biomass, size, and distribution of large-jellyfish were measured during July and September of 2018 and 2019 as part of the Northern Gulf of Alaska Long-Term Ecological Research (NGA-LTER) cruises. Nearly 1000 kg dispersed among ~13,800 jellies were collected using a 5 m² Methot net. Catches were dominated by two macro-jellies, the hydrozoan Aequorea sp. and the scyphozoan Chrysaora sp. During 2018, epipelagic macro-jellies biomass averaged 1.46 ± 0.36 g WW m⁻³ for July and 1.14 ± 0.23 g WW m⁻³ for September, while during 2019 they averaged 0.86 ± …

If Women Were Dragons: A Study Of The Conquest Of Women And Dragons In Ragnar's Saga, The Volsunga Sagas, And The Nibelungenlied, Claire-Elise A. Baalke

English

This thesis is a study displaying the connections between female characters and dragons in Old Norse and Middle High Germanic literature. The main associations that I examine are the ways that female characters and dragons share the characteristics of greed or hoarding, prophetic sight or supernatural power, and "monstrosity" or "Otherness." The fundamental argument is that the women and dragons have common characteristics which define them as dangerous and thereby cause the men or heroes of the tale to feel the need to silence or depower them through conquest. Typically, the dragon is the barrier between the woman and the …

Community Composition And Biogeography Of Beetles And Spiders Across An Elevational Gradient In Denali National Park, Alaska, Adam Haberski

Biological Sciences

Anthropogenic climate change is rapidly altering alpine ecosystems in Alaska. Trees and woody shrubs are expanding upslope and displacing alpine tundra. As alpine tundra habitats shrink and fragment, arthropods and other animals face an increased risk of extirpation due to smaller population sizes and reduced geneflow. Arthropods--insects, spiders, and their relatives--are the most speciose component of the alpine fauna and perform key ecosystem services, such as pollination and nutrient cycling, and are food for vertebrates. Many species have responded by shifting their distribution to higher elevations, but species respond to change idiosyncratically, which could alter species interactions and disrupt communities. …

Fate And Effects Of Commercial Crude Oil Bioremediation Products In Arctic Seawater, Taylor R. Gofstein

Chemistry and Biochemistry

With increased oil exploration, development, and transport in the Arctic in recent years, the potential for disastrous oil spills is imminent. Biodegradation, the consumption of contaminants by indigenous microorganisms capable of using them as an energy source, can be enhanced using bioremediation treatments and may be a viable spill remediation method when traditional physical recovery techniques are not. The EPA National Contingency Plan (NCP) product schedule lists oil spill response treatments that can be used in the event of a spill, many of which can stimulate intrinsic biodegradation. However, there is often little to no experimental data demonstrating the effectiveness …