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Clopyralid Uptake Of Contaminated Compost‐Fertilised Corn, Ryuichi Uegaki, Munehiro Ebato, Madoka Sutoh, Yimin Cai

IGC Proceedings (1977-2023)

No abstract provided.

Medical School Watercooler Newsletter - August 23, 2020, Lindsey Lyle

Watercooler Newsletter

This is the August 23, 2020 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

Med School Café video online: 'Chest Wall Reconstruction'

Menger answers the call to treat patients in COVID-19 hotspot

Mark your calendar: Upcoming grand rounds

USA researchers study significance of RAB genes in pancreatic cancer

Bander Award supports e-cigarette research

Research On "Zero Discharge" Technical Route Of International Ship Pollutants, Zilin Zhen

Maritime Safety & Environment Management Dissertations (Dalian)

No abstract provided.

Research On Regulation Of Non-Traditional Safety Behavior At Sea : From The Perspective Of Law And Policy, Yunze Yi

Maritime Safety & Environment Management Dissertations (Dalian)

No abstract provided.

A Study Of The Human Factors In Maritime Safety, Mengwei Sha

Maritime Safety & Environment Management Dissertations (Dalian)

No abstract provided.

Study On Ship Officer1’S Labor Intensity And Duty Arrangement, Jianan Huang

Maritime Safety & Environment Management Dissertations (Dalian)

No abstract provided.

Feasibility Study On Environmental Protection Reform Of Ship Stern Tube System Based On Water Lubrication, Yang Cui

Maritime Safety & Environment Management Dissertations (Dalian)

No abstract provided.

The Impact Of Stream-Groundwater Exchange On Seasonal Nitrate Loads In An Urban Stream, Julio I. Beltran

Theses - ALL

Urbanization negatively impacts water quality in streams by reducing stream-groundwater interactions, which reduces the stream’s ability to naturally attenuate nitrate. Meadowbrook Creek, a first order urban stream in Syracuse, New York, has a negative urbanization gradient that results in urbanized headwaters that are disconnected from the floodplain, and downstream reaches that have intact riparian floodplains and connection to riparian aquifers. This system allows us to assess how stream-aquifer interactions in urban streams impact the net sources and sinks of nitrate at the reach scale. We used continuous (15-minute) streamflow measurements, along with weekly grab samples at three gauging stations positioned …

Mapping The Molecular Interface Of A Gpcr Dimer, Zhenqi Li

Theses - ALL

G-protein-coupled receptors (GPCRs) are the most diverse membrane proteins in eukaryotes that transmit chemical signals to the cell. GPCRs are considered the largest family of targets for approved drugs on the market. Sphingosine 1-phosphate receptor 1 (S1P1), a widely expressed GPCR protein in many cell types, performs signal transduction function not only in the monomeric state but also in the dimeric or complex oligomeric states. However, the detail of the S1P1 assembly is still not clearly understood. Cholesterol is believed to affect S1P1 dimerization, but the details of the cholesterol-binding sites with S1P1 are not well understood. In this project, …

Cell-Adhesion Activities Responding To Nano-Dynamic Substrate, Huaiyu Shi

Theses - ALL

Focal adhesions are the large molecular complexes that anchor cells to the ECM, which is involved in cell spreading, migration, and proliferation. In our previous work, the study of cardiomyocyte morphological changes and myofibril remodeling, responding to the dynamic nano-topographic substrate, have been accomplished. The results showed focal adhesion experienced disassembly and reassembly in the first 12 hours. In this study, the hiPSC-CMs were seeded on the SMP substrates with the flat-to-wrinkle dynamic surface. Paxillin, vinculin, and zyxin from different layers of focal adhesive architectures were co-stained with F-actin. The fluorescent images were analyzed to investigate the details of focal …

Book Review: Reconnecting To The Source By Ervin Laszlo, Elizabeth W. Szatmari Krasnoff

Journal of Conscious Evolution

Quantum philosopher Ervin Laszlo has taken one step further outside of the contemporary mainstream scientific view, which believes in a reductive “scientific” method primarily of highly controlled experiments to determine truth. In this visionary work, Laszlo proposes that the true laws of nature can also be accessed and felt experientially. Here he argues that the new quantum science can support this view, and even assist us as we heal the rift between mind and spirit and reconnect to our source. Laszlo proposes a new paradigm, a holotropic worldview with love as the core attracting force of wholeness. Indeed, as the …

Expanding The Potential Prenylome: Prenylation Of Shortened Target Substrates By Ftase And Development Of Fret-Based System For Detecting Potentially “Shunted” Proteins, Sudhat Ashok

Dissertations - ALL

Protein prenylation is a posttranslational modification involving the attachment of a C15 or C20 isoprenoid group to a cysteine residue near the C-terminus of the target substrate by protein farnesyltransferase (FTase) or protein geranylgeranyltransferase type I (GGTase-I), respectively. Both of these protein prenyltransferases recognize a C-terminal "CaaX" sequence in their protein substrates, but recent studies in yeast- and mammalian-based systems have demonstrated FTase can also accept sequences that diverge in length from the canonical four-amino acid motif, such as the recently reported five-amino acid C(x)3X motif. In this work, we further expand the substrate scope of FTase by demonstrating sequence-dependent …

Stress And Alcohol Use: An Experimental Investigation Of Cognitive Mechanisms, Katherine Anne Buckheit

Dissertations - ALL

Research suggests that exposure to stressors is associated with greater alcohol consumption, more alcohol-related problems, and a greater likelihood of Alcohol Use Disorder. Theory suggests that cognitive processes, particularly unconscious cognitive processes, are key in determining a coping strategy but both alcohol and chronic exposure to stressors may interfere with these processes. The current study tested one such process, attention bias to alcohol cues, as a mediator in the stressor-alcohol relationship. Thirty-nine participants who endorsed hazardous alcohol consumption patterns were recruited from the community; eligible participants were randomly assigned to a stress-exposure or non-stressful control condition. Participants completed assessments of …

Evolution Acceptance, Religiosity, And Nature Of Science In An Undergraduate Population, Ryan D.P. Dunk

Dissertations - ALL

Decades of research into the acceptance of evolutionary biology have revealed a number of factors that are related to an individual’s choice to accept or reject evolutionary biology. This work seeks to extend that work in the following key ways: (1) Use a longitudinal time frame, along with multifactorial linear modeling, to investigate the changes in evolution acceptance and its associated factors across a year of introductory biology education. (2) Expand the study population to a general undergraduate population, and study the change in acceptance of evolution in this general student population across the first semester of university education. (3) …

Investigating The Parameters Affecting The Sensitivity Of A Protein Nanopore Sensor, Motahareh Ghahari Larimi

Dissertations - ALL

In the last three decades nanopore sensing has emerged as a powerful technique for DNA sequencing and bio-molecular sensing. One of the great appeals of this technique is that it usually does not require any labeling or chemical modification. Additionally, its ability to examine a single molecule in real time is a rare feature which is not achievable with most of other techniques. In recent years, great efforts have been made to design a nanopore sensor for sampling peptide-protein and protein- protein interaction. To pave the way for designing a high-throughput wearable nanopore sensor, we will investigate a few of …

Medical Cannabis Use Among Chronic Pain Patients And Associations With Prescription Opioid Use: A Retrospective Study, Jesse Kosiba

Dissertations - ALL

Medical cannabis is increasingly used as a treatment for chronic pain, and there is initial evidence that medical cannabis may lead to a subsequent decrease in prescription opioid use. The objective of the current study was to conduct a retrospective, naturalistic examination of medical cannabis use (i.e., dose, frequency, type) and subsequent changes in prescription opioid use among a sample of treatment-seeking chronic (non-cancer-related) pain patients (N =277). Data from the electronic medical record (EMR) was paired with information from the State Prescription Drug Monitoring Program and collected at time of initial certification and at six months post-certification. Results indicated …

Effects Of Surface Topography On Bacterial Biofilm Formation, Sang Won Lee

Dissertations - ALL

Biofilms are multicellular structures with bacterial cells attached to a surface and embedded in an extracellular matrix. With high-level resistance to antimicrobial agents, biofilms are the cause of chronic infections associated with implanted medical devices such as breast implants, orthopedic devices, pace markers, and many others. Besides the prevalence, biofilm infections are associated with high mortality, presenting an urgent need for more effective controls. Several strategies such as coating with antimicrobial agents and changing chemical, physical, and biological properties of biomaterials have been attempted, but bacteria have remarkable capabilities to overcome unfavorable conditions over time and long-term biofilm control remains …

Earth’S Oceanic Oxygen History From Phanerozoic To Pleistocene Glacial Cycles: Insights From The Carbonate Iodine-To-Calcium Proxy, Wanyi Lu

Dissertations - ALL

Oxygen in the oceans is an important part of the significant and complex evolution of Earth’s climate, with great significance for the evolution of life in the oceans. My PhD research has been primarily driven by three major questions: (1) How can we reliably reconstruct oxygen levels in ancient oceans? (2) How did oceanic oxygen levels evolve throughout Earth’s history? (3) How did oceanic oxygen levels affect habitability of the Earth? Most studies of the Earth’s oxygen history have focused on the atmosphere and deep oceans, but in contrast, I focused on the upper ocean (the top tens to a …

Development And Efficient Implementation Of Electron-Hole Interaction Kernel For Investigation Of Electronic Excitations In Semiconductor And Metallic Nanoparticles, Peter Francis Mclaughlin

Dissertations - ALL

The focus of this work is to construct theoretical methods or approaches to tackle computationally challenging problems in quantum chemistry. The primary topic of the work will focus on efficient theories that allow for capturing electron-correlation in semiconductor or metallic nanoparticles. These systems are computationally challenging due to the size of the systems, the number of electrons per atom, and the degeneracy of the particle-hole states. Three methods presented here are aimed at providing novel theoretical methods towards computationally inexpensive electronic excited state calculations. The frequency-dependent geminal-screened electron-hole interaction kernel (FD-GSIK) method provides a real-space approach towards eliminating the virtual …

Fluidization And Segregation In Confluent Models For Biological Tissues, Preeti Sahu

Dissertations - ALL

Collective tissue dynamics, more specifically a tissue's ability to fluidize and segregate, is imperative for proper embryonic development and normal physiological functioning. In this thesis, I use vertex models to understand how cell-scale properties govern large-scale collective behavior. I begin with the process of fluidization in ordered monolayers. By perturbing beyond the linear regime, I show that in confluent tissues the linear response does not correctly predict the non-linear behavior, which, in this case, is the ability to exchange neighbors and fluidize. We also construct a simple analytic ansatz that can predict the non-linear behaviour responsible for cellular motion in …

Spectroscopy Versus Turbidity: Non-Invasive In Vivo Monitoring Of Living Systems, Seth Fillioe

Dissertations - ALL

The overall aim is to advance the use of light for noninvasive monitoring of living systems generally defined. We first describe work used to test a methodology for real-time probing of chemical and physical changes in spinal cords in the immediate aftermath of a localized contusive injury by way of calculating pH to monitor physiological changes in the system. Utilizing a previously developed unique algorithm, line scans of injured cords as well as optical profilimetry and scanning NIR autofluorescence images were obtained simultaneously in vivo, on exposed rat spinal cords. For line scans, the laser spatially scanned across the cord …

Knowledge Of The Female Athlete Triad And Relative Energy Deficiency In Sport Amongst Female Distance Runners And Their Support Staff, Melissa Lodge

Theses - ALL

There has been an increased participation of female athletes competing in the NCAA for the past thirty years. Amongst these female athletes, there is an increased risk of stress fracture (SFx) injury, which is highly prevalent among female endurance sports. Female athletes, especially those participating in endurance sports (i.e. distance running), exhibit an increases risk of developing The Female Athlete Triad (the Triad) and Relative Energy Deficiency in Sport (RED-S). The Triad and RED-S are conditions that explore the health and performance consequence of low energy availability (LEA) amongst athletes. Few studies to date have assessed the knowledge that athletes, …

Elucidation Of Ubqln2 Liquid-Liquid Phase Separation Mechanisms Via Point Mutations And Domain Deletions, Holly Brianne Jones

Theses - ALL

Organization, separation, and cellular regulation are all functions of membraneless organelles (MLOs), which arise by a biophysical phenomenon termed liquid-liquid phase separation (LLPS). By this process, macromolecules in a mixed liquid solution condense together to form liquid droplets within a liquid solution, comparable to oil droplets in water. Some known MLOs formed in cells via LLPS include nucleoli, stress granules, Cajal bodies, and processing-bodies, among other membrane-lacking liquid granules. Previous work has shown that many proteins which compose these liquid compartments also undergo LLPS isolated in vitro, and thus have become model systems to investigate the forces that drive these …

Axillary Artery Variation: The Rule Not The Exception, Cameron M. Thiele, Danielle A. Thornburg, Sonya E. Van Nuland, Natalie R. Langley

School of Medicine Faculty Publications

Introduction: Anatomic morphology commonly depicted in atlases or textbooks is often emphasized in gross anatomy classrooms; however, considerable variation may be observed in cadavers during dissection, particularly in the vascular system. This study statistically assesses the frequency of the classic versus variant axillary artery branching pattern and compares these observations to the incidence of variation described in the literature. Material and Methods: Axillary artery branching pattern was studied in 62 cadaver limbs. A Chi square goodness of fit test with post hoc analyses on the adjusted standardized residuals was used to evaluate branching patterns. Results: A statistically significant difference existed …

Opioid Dependency And Its Effects On Alcohol Consumption, Emily V. Flores

Psychology and Counseling Theses

Previous research has found dualistic effects on alcohol consumption with low doses of buprenorphine increasing alcohol and higher doses of buprenorphine reducing alcohol consumption in rats (Ciccocioppo et al., 2006). Other existing research on naloxone treatment and alcohol consumption in opioid use has demonstrated that alcohol consumption decreases after naloxone treatment in rats (Hyytia & Sinclair, 1993). Yet, no research has been conducted on either rats or humans on the effects of buprenorphine and naloxone medication combined. The effects of opioid maintenance therapy are controversial and the relationship between alcohol consumption and opioid dependency treatment is mainly based on literature …

Structural And Functional Insights Into Ghrelin Acylation By Ghrelin O-Acyltransferase, Maria Campana

Dissertations - ALL

Ghrelin is a peptide hormone primarily secreted by the stomach that acts as the endogenous ligand for the GHSR1a G-protein-coupled receptor. This 28 amino acid peptide stimulates appetite and has been associated with the cardiovascular, gastrointestinal, neuroendocrine, and immune systems. Ghrelin requires a unique posttranslational modification to be biological active. Ghrelin O-acyltransferase (GOAT) is responsible for catalyzing octanoylation of the 3rd serine side chain of ghrelin to generate the active form of this hormone. Thus, GOAT is considered as a potential therapeutic target for treatment of obesity and other disorders linked to the peptide. Yet, the active site architecture and …

Elucidating Dopant Migration Mechanism For The Controlled Dopant Locations/Distribution Within Core/Shell Nanocrystals, Elan Hofman

Dissertations - ALL

Understanding the fundamental principles behind transition metal ion doped semiconducting materials has drawn immense interest when designing ideal systems for use in optical and electronic devices. Dopant ions have been found to diffuse/migrate throughout solid materials when the thermal energy of the system is elevated above a temperature boundary allowing the cations and anions within a system to move freely. Nanomaterials such as 0-dimensional (0D) quantum dots (QDs), 1D nanorods/nanowires, and 2D nanoplatelets have unique dopant-location dependent optical and electronic properties which can be drastically altered based on the final dopant sites and distribution throughout the material. This work focuses …

Rigidity In Frictional Particle Packings And Dynamics In Living Polymeric Packings, Kuang Liu

Dissertations - ALL

indicated by the title, this is a thesis in two acts. The first act encapsulates a study of the rigidity transition in frictional particle packings, or how a packing goes from floppy-to-rigid as its particle density increases, for example. While consensus has emerged regarding the nature of the rigidity transition in frictionless packings, there is much less consensus with frictional packings. Therefore, I introduce two new complementary concepts, frictional rigidity percolation and minimal rigidity proliferation, to help identify the nature of the frictional rigidity transition. To probe frictional rigidity percolation, I construct rigid clusters using a (3,3) pebble game for …

Investigating The Relationships Between Disorder, Structure, And Dynamics In Amorphous Systems, Ethan Stanifer

Dissertations - ALL

In this thesis, we investigate the relationships between the disorder, structure, and deformation in amorphous materials. First, to understand the surprising low-frequency vibrational modes in structural glasses, and how it arises from the microscopic disorder in the system, we study the spectra of a large ensemble of sparse random matrices where disorder is controlled by the distribution of bond weights and network coordination. When there is a finite probability density of infinitesimal bond weights, we find a region in the vibrational density of states that is consistent with the low-frequency behavior in structural glasses. Next, in order to investigate structural …

Effect Of Grazing On Soil Structure And Consequences For Soil Mechanical And Hydraulic Propertiesin Inner Mongolia, A. Reszkowska, J. Krümmelbein, S. Peth, L. Gan, X. Peng, R. Horn

IGC Proceedings (1977-2023)

No abstract provided.