Digital Commons Network^™

Association Between Bioactive Molecules In Breast Milk And Type 1 Diabetes Mellitus, Tajudeen Yahaya, Ufuoma Shemishere

Sultan Qaboos University Medical Journal

The association between breastfeeding and type 1 diabetes mellitus (T1DM) is controversial. However, several recent studies have established a link between these two factors, necessitating a need to review this subject to raise public awareness. Current research indicates that breast milk contains a variety of bioactive substances including immunoglobulins, oligosaccharides, insulin, lactoferrin, lysozyme, cytokines, epidermal growth factors, leukocytes, nucleotides, beneficial bacteria and vitamins. Such substances strengthen the breastfeeding infant’s immune system, both directly, by increasing gut microbiota diversity and attacking harmful bacteria and proinflammatory molecules, and indirectly, by increasing thymus performance. Accordingly, a lack of or inadequate breastfeeding may predispose …

Lipocalin-2 Deficiency May Predispose To The Progression Of Spontaneous Age-Related Adiposity In Mice, Keya Meyers, María López, Joanna Ho, Savannah Wills, Srujana Rayalam, Shashidharamurthy Taval

PCOM Scholarly Works

Lipocalin-2 (Lcn2) is an innate immune protein elevated by several orders of magnitude in various inflammatory conditions including aging and obesity. Recent studies have shown that Lcn2 is secreted by adipocytes in response to inflammation and is categorized as a new adipokine cross-linking innate immunity and metabolic disorders including obesity. However, the involvement of Lcn2 and its function during the progression of obesity is largely unknown. Recently, browning of white adipose tissue (WAT) has gained attention as a therapeutic strategy to combat obesity. Herein, we have shown that treatment of mature 3T3-L1 adipocytes with recombinant Lcn2 (rec-Lcn2) resulted in the …

Severe Immunosuppression And Not A Cytokine Storm Characterizes Covid-19 Infections, Kenneth E Remy, Monty Mazer, David A Striker, Ali H Ellebedy, Andrew H Walton, Jacqueline Unsinger, Teresa M Blood, Philip A Mudd, Daehan J Yi, Daniel A Mannion, Dale F Osborne, R Scott Martin, Nitin J Anand, James P Bosanquet, Jane Blood, Anne M Drewry, Charles C Caldwell, Isaiah R Turnbull, Scott C Brakenridge, Lyle L Moldwawer, Richard S Hotchkiss

Open Access Publications

COVID-19-associated morbidity and mortality have been attributed to a pathologic host response. Two divergent hypotheses have been proposed: hyperinflammatory cytokine storm; and failure of host protective immunity that results in unrestrained viral dissemination and organ injury. A key explanation for the inability to address this controversy has been the lack of diagnostic tools to evaluate immune function in COVID-19 infections. ELISpot, a highly sensitive, functional immunoassay, was employed in 27 patients with COVID-19, 51 patients with sepsis, 18 critically ill nonseptic (CINS) patients, and 27 healthy control volunteers to evaluate adaptive and innate immune status by quantitating T cell IFN-ɣ …

Best Practices For Successfully Writing And Publishing A Genome Announcement In Microbiology Resource Announcements, Julie C. Dunning Hotopp, David A. Baltrus, Vincent M. Bruno, John J. Dennehy, Steven R. Gill, Julia A. Maresca, Jelle Matthijnssens, Irene L. G. Newton, Catherine Putonti, David A. Rasko, Antonis Rokas, Simon Roux, Jason E. Stajich, Kenneth M. Stedman, Frank J. Stewart, J. Cameron Thrash

Bioinformatics Faculty Publications

Microbiology Resource Announcements (MRA) provides peer-reviewed announcements of scientific resources for the microbial research community. We describe the best practices for writing an announcement that ensures that these publications are truly useful resources. Adhering to these best practices can lead to successful publication without the need for extensive revisions.

September 3, 2020, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Kenyon Collegian - September 3, 2020

The Kenyon Collegian

No abstract provided.

The George-Anne, Georgia Southern University

The George-Anne

• SAY THEIR NAMES... KNOW THEIR STORIES...
• An open letter to the Georgia Southern Community
• Two employees die from COVID-19, two similar statements released
• On-campus residents resist new COVID-19 policies
• On-campus tours return to Southern
• Greek life goes virtual
• Student Resources on Campus
• Is social distancing working on campus?
• We Asked, You Responded
• Dingus MaGee's temporarily closes citing COVID-19 concerns
• The Blue Room to temporarily close effective immediately
• Southern Adventures changes
• Football practice suspended

A Preliminary Study Interrogating The Cataloging And Classification Schemes Of A K-12 Book Discovery Platform Through A Critical Race Theory Lens, Kafi D. Kumasi, Cynthia Jimes, Amee Evans Godwin, Lisa A. Petrides, Anastasia Karaglani

School of Information Sciences Faculty Research Publications

This article presents the results of a preliminary study to examine the cataloging and classification schemes and ideological factors that play out in book discovery platforms for children’s and young adult books. Using Critical Race Theory and a Rapid Contextual Design approach to exploring the curatorial behaviors of school librarians when searching for diverse books, the study offers design ideas for retooling discovery platforms in ways that bridge the cultural disconnect that young adults from historically marginalized racial backgrounds experience in their libraries. The article concludes that in order for school librarians to find, recommend and teach about books that …

Structural Insights Of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes, Xinzhe Yu, Ping Yi, Ross A Hamilton, Hong Shen, Muyuan Chen, Charles E Foulds, Michael A Mancini, Steven J Ludtke, Zhao Wang, Bert W O'Malley

Faculty, Staff and Students Publications

Steroid receptors activate gene transcription by recruiting coactivators to initiate transcription of their target genes. For most nuclear receptors, the ligand-dependent activation function domain-2 (AF-2) is a primary contributor to the nuclear receptor (NR) transcriptional activity. In contrast to other steroid receptors, such as ERα, the activation function of androgen receptor (AR) is largely dependent on its ligand-independent AF-1 located in its N-terminal domain (NTD). It remains unclear why AR utilizes a different AF domain from other receptors despite that NRs share similar domain organizations. Here, we present cryoelectron microscopy (cryo-EM) structures of DNA-bound full-length AR and its complex structure …

Community Detection Algorithm In Multi-Relational Networks, Jingping Yu, Zheng Jie, Guixiang Zhu

Journal of System Simulation

Abstract: In view of the traditional community detection algorithms being mainly applied to single relational networks, ignoring the interaction of relationship in the multi-relational networks, being unable to distinguish the importance of each relation for community detection, a novel algorithm called InteractRank was proposed. Based on the node and the relation of ranking model, the algorithm could transform multi-relational network into single relational network. Combined the PageRank algorithm and the random walk model, the algorithm considered the connection within groups and between groups in multi-relational networks. After transforming into single relational networks, spectral clustering algorithm was adopted to detect community. …

The Societal Influence Of The Nba, Kyle Kawashiri

Pop Culture Intersections

Based on recent events, there has been a lot of discussion about the racial issues in America. Many professional athletes have been vocal about these issues, but NBA players seem to be at the forefront of many of the conversations regarding social injustice in this country. This article will examine different factors that have influenced the popularity of the National Basketball Association, such as product distribution, online engagement, global outreach, and the choice to allow players to use their platforms. The article will then argue how these factors have allowed the NBA and its players to be leaders in the …

National Water Quality Initiative (Nwqi) Watershed Assessment For: Little Hunting Slough-Black River Watershed (Huc- 110100070805), Marc R. Owen, Sierra N. Casagrand, Kayla A. Coonen, Robert T. Pavlowsky

OEWRI Technical Reports

In 2012, the U.S. Department of Agriculture through the National Resources Conservation Service (NRCS) implemented the National Water Quality Initiative (NWQI) aimed at reducing nutrients and sediment in the nation’s rivers and streams. The goal of the NWQI program is for the NRCS and its partners to work with landowners to implement voluntary conservation practices that improve water quality in high-priority watersheds while maintaining agricultural productivity. While high-priority watersheds have been selected around the country, typically watershed-scale evaluations identifying specific pollution sources and the conservation practices needed to improve water quality are not available to field office staff responsible for …

Commonwealth Times 2020-09-02

Commonwealth Times, 1969-

No abstract provided.

Flexible Coordinator And Switcher Hubs For Adaptive Task Control, Carrisa V. Cocuzza, Takuya Ito, Douglas H. Schultz, Dabielle D. Bassett, Michael W. Cole

Center for Brain, Biology, and Behavior: Faculty Publications

Functional connectivity (FC) studies have identified at least two large-scale neural systems that constitute cognitive control networks, the frontoparietal network (FPN) and cingulo-opercular network (CON). Control networks are thought to support goal-directed cognition and behavior. It was previously shown that the FPN flexibly shifts its global connectivity pattern according to task goal, consistent with a “flexible hub” mechanism for cognitive control. Our aim was to build on this finding to develop a functional cartography (a multimetric profile) of control networks in terms of dynamic network properties. We quantified network properties in (male and female) humans using a high-control-demand cognitive paradigm …

Dstyk Promotes Metastasis And Chemoresistance Via Emt In Colorectal Cancer, Jinyu Zhang, Zachary Miller, Phillip R. Musich, Ashlin E. Thomas, Zhi Q. Yao, Qian Xie, Philip H. Howe, Yong Jiang

ETSU Faculty Works

Objective: Tumor metastasis and resistance to chemotherapy are two critical factors that contribute to the high death rate of colorectal cancer (CRC) patients. Metastasis is facilitated by the epithelial-mesenchymal transition (EMT) of tumor cells, which has emerged not only as a fundamental process during metastasis, but is also a key process leading to chemoresistance of cancer cells. However, the underlying mechanisms of EMT in CRC cell remain unknown. Here, we aim to assess the role of dual serine/threonine and tyrosine protein kinase (DSTYK) in CRC metastasis and chemoresistance. Methods: To study the role of DSTYK in TGF-β-induced EMT, we employed …

A Call For Action To Safely Deliver Oral Health Care During And Post Covid-19 Pandemic, Marco Farronato, Santosh K. Tadakamadla, Mir Faeq Ali Quadri, Shashidhar Acharya

Open Access archive

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak started just a couple of months ago and it grew rapidly causing several deaths and morbidities. The mechanism behind the transmission of the virus is still not completely understood despite a multitude of new specific manuscripts being published daily. This article highlights the oral cavity as a possible viral transmission route into the body via the Angiotensin converting enzyme 2 receptor. It also provides guidelines for routine protective measures in the dental office while delivering oral health care.

Effect Of High Glucose On Ocular Surface Epithelial Cell Barrier And Tight Junction Proteins, Saleh M. Alfuraih, Ashley Barbarino, Christopher Ross, Kiumars Shamloo, Vishal Jhanji, Miao Zhang, Ajay Sharma

Pharmacy Faculty Articles and Research

PURPOSE. Patients with diabetes mellitus are reported to have ocular surface defects, impaired ocular surface barrier function, and a higher incidence of corneal and conjunctival infections. Tight junctions are critical for ocular surface barrier function. The present study was designed to investigate the effect of high glucose exposure on human corneal and conjunctival epithelial cell barrier function and tight junction proteins.

METHODS. Human corneal and conjunctival epithelial cells were exposed to 15 mM and 30 mM glucose for 24 and 72 hours. The barrier function was measured using transepithelial electrical resistance (TEER). The cell migration was quantified using scratch assay. …

Wyatt, Alumnus Head To Kennedy Space Center, Prepare For Next Space Flight, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

African League Against Rheumatism (Aflar) Preliminary Recommendations On The Management Of Rheumatic Diseases During The Covid-19 Pandemic, Richard Oluyinka Akintayo, Rachid Bahiri, Yasser El Miedany, Hakeem Olaosebikan, Asgar Ali Kalla, Adewale Olukayode Adebajo, Angela Migowa, Samy Slimani, Ouma Devi Koussougbo, Ben Abdelghani Kawther

Paediatrics and Child Health, East Africa

Objectives: To develop recommendations for the management of rheumatic and musculoskeletal diseases (RMDs) during the COVID-19 pandemic.

Method: A task force comprising of 25 rheumatologists from the 5 regions of the continent was formed and operated through a hub-and-spoke model with a central working committee (CWC) and 4 subgroups. The subgroups championed separate scopes of the clinical questions and formulated preliminary statements of recommendations which were processed centrally in the CWC. The CWC and each subgroup met by several virtual meetings, and two rounds of voting were conducted on the drafted statements of recommendations. Votes were online-delivered and …

September 2, 2020 General Faculty Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Trace Mineral Leaching From Equine Compost, Ashley L. Fowler, Mieke Brummer-Holder, Karl A. Dawson

Animal and Food Sciences Faculty Publications

Mineral leaching from compost can be environmentally disruptive. Little information is available regarding trace mineral leaching from equine-sourced compost. The objective of this study was to quantify the mineral content and leaching potential of compost produced from feces of horses fed different amounts and forms (organic or inorganic) of trace minerals. Nine horses were fed three treatments in a 3 × 3 replicated Latin Square design. The dietary treatments were provided as a daily pellet: CON (pellet without added trace minerals), ING (added inorganic trace minerals), and ORG (added organic trace minerals). The added trace minerals were Co, Cu, Mn, …

The Antelope, University Of Nebraska At Kearney

The Antelope

No abstract provided.

Family Matters: Decade Review From Journal Of Family And Economic Issues, Heather H. Kelly, Ashley B. Lebaron, E. Jeffery Hill

Faculty Publications

This article reviews research regarding economic influences on a variety of family matters published in Journal of Family and Economic Issues from 2010 to 2019. As finances permeate nearly every facet of everyday life, scholarly research related to finances and family issues has spanned a wide array of topics. We briefly review research focused on the following 11 areas related to finances and family matters: (a) family formation decisions, (b) gender and relational power in family finances and relationships, (c) finances and fathers, (d) finances and mothers, (e) finances and parenting, (f) finances and elderly family members, (g) finances and …

A Scoring Model To Evaluate Offshore Oil Projects: Case Of Eni And Mellitah Oil & Gas, Abdulhakim Giadedi

Dissertations and Theses

Offshore oil projects have many different and unique characteristics, such as larger project size, higher number of scopes, and higher complexity. In fact, offshore oil projects described as mega projects are ones that require significant assessment and acquisition methods in order to reduce risks and failures. Traditionally, cash flow analysis and return on investment are the most known factors to evaluate offshore oil projects. However, there are several other internal and external factors that affect the overall performance of offshore oil projects. A comprehensive approach and advanced tools are required to evaluate these factors that can have a significant impact …

Mclean Interns Empower Communities Through Challenging Times, Jaycee Brown

University of Mississippi News

Ole Miss students spend summer engaging in public service in north Mississippi communities

Everything Is Science: A Free City-Wide Science Festival, Jarrod W. Creameans, Michelle G. Pitts, Olivia White, Kellen M. Greenwell, Kristie Colón, Sylvie Garneau-Tsodikova, Vincent J. Venditto

Pharmaceutical Sciences Faculty Publications

A week-long, city-wide science festival called Everything is Science (EiS) was developed to educate the community in an informal manner. The festival serves as a platform for presenters from diverse professions to give engaging talks (without PowerPoint slides) to the public, free of charge, in restaurants and bars around town. Over 350 people attended the events over 5 days with 33 presenters. Surveys completed by attendees and session coordinators indicate strong support for this festival. Altogether, the EiS festival serves as a no-cost method to engage with the community and improve science literacy with potential for adoption in other cities.

Does The Presence Of Multiple Β-Lactamases In Gram-Negative Bacilli Impact The Results Of Antimicrobial Susceptibility Tests And Extended-Spectrum Β-Lactamase And Carbapenemase Confirmation Methods?, Fred C. Tenover, Caitlin M. Dela Cruz, Scott Dewell, Victoria M. Le, Isabella A. Tickler

Biology Faculty Publications

Objectives: Many multidrug-resistant Gram-negative bacilli (MDR-GNB) harbour multiple β-lactamases. The aim of this study was to assess the impact of multiple β-lactamase carriage on the accuracy of susceptibility tests and extended-spectrum β-lactamase (ESBL) and carbapenemase confirmation methods.

Methods: A total of 50 MDR-GNB, of which 29 carried multiple β-lactamases, underwent broth microdilution (BMD) and disk diffusion (DD) testing as well as confirmation tests for ESBLs and carbapenemases. Whole-genome sequencing (WGS) was used for β-lactamase gene identification.

Results: Categorical agreement of BMD and DD testing results ranged from 86.5 to 97.7% for 10 β-lactam agents. BMD and DD algorithms for ESBL …

The Rattler (Volume 109, Issue 1), St. Mary's University

The Rattler (Previous issues)

Founded in 1919, The Rattler is the student voice of St. Mary’s University in San Antonio, Texas. The newspaper documents campus life, academic and social issues, student opinion, and local and national events as they relate to the University community. Content typically includes news articles, editorial commentary, arts and culture coverage, sports reporting, and advertisements.

Are Pangolins Scapegoats Of The Covid-19 Outbreak-Cov Transmission And Pathology Evidence?, Siew Woh Choo, Jinfeng Zhou, Xuechen Tian, Siyuan Zhang, Shen Qiang, Stephen James O'Brien, Ka Yun Tan, Sara Platto, Klaus-Peter Koepfli, Agostinho Antunes, Frankie Thomas Sitam

Biology Faculty Articles

The COVID‐19 outbreak has infected over 6 million people across the world. The origin of COVID‐19 coronavirus (CoV) remains unknown, although pangolins have been suggested as potential hosts. We investigated two pangolins seized in Guangdong Province, China. Molecular screening revealed CoV in one pangolin (“Dahu”), while another (“Meidong”) was infected by Ehrlichia ruminantium. Dahu exhibited difficulty breathing, infections of lung, intestines, and nostrils, as revealed by computed tomography imaging and necropsy. Previous phylogenetic analyses showed bat coronavirus RaTG13 is closer to COVID‐19 CoV compared to pangolin coronavirus. Over 20 caregivers have had close physical contact with CoV‐positive Dahu, but …

Lethal Autonomous Weapon Systems: Translating Geek Speak For Lawyers, Linell A. Letendre

International Law Studies

This article provides an overview of robotics and autonomous systems so that attorneys can better understand the systems and design principles of lethal autonomous weapon systems (LAWS) that may be used in an armed conflict. Using the lens of establishing a common language between engineers and attorneys, the article introduces the basics of robotics terminology, explores how autonomous systems work by explaining control systems and control architecture, and examines how autonomous systems learn and reason. It also suggests a number of questions attorneys should ask engineers during the design process in order to ensure autonomous systems are designed in a …