Digital Commons Network^™

Dietary Methionine Restriction Signals To The Brain Through Fibroblast Growth Factor 21 To Regulate Energy Balance And Remodeling Of Adipose Tissue, Laura A. Forney, Han Fang, Landon C. Sims, Kirsten P. Stone, Leighann Y. Vincik, Alicia M. Vick, Amanda N. Gibson, David H. Burk, Thomas W. Gettys

Faculty Publications

© 2020 The Obesity Society. Objective: Restricting dietary methionine to 0.17% in mice increases energy expenditure (EE), reduces fat deposition, and improves metabolic health by increasing hepatic fibroblast growth factor 21 (FGF21). The goal of this study was to compare each of these responses in mice with the coreceptor for FGF21 deleted in either adipose tissue or the brain. Methods: Methionine-restriction (MR) diets were fed to age-matched cohorts of mice with the coreceptor for FGF21 deleted in either adipose tissue or the brain. The physiological and transcriptional responses to MR were compared in the respective cohorts. Results: Tissue-specific deletion of …

A Tree Frog (Boana Pugnax) Dataset Of Skin Transcriptome For The Identification Of Biomolecules With Potential Antimicrobial Activities, Yamil Liscano Martinez, Claudia Marcela Arenas Gómez, Jeramiah J. Smith, Jean Paul Delgado

Biology Faculty Publications

Increases in the prevalence of multiply resistant microbes have necessitated the search for new molecules with antimicrobial properties. One noteworthy avenue in this search is inspired by the presence of native antimicrobial peptides in the skin of amphibians. Having the second highest diversity of frogs worldwide, Colombian anurans represent an extensive natural reservoir that could be tapped in this search. Among this diversity, species such as Boana pugnax (the Chirique-Flusse Treefrog) are particularly notable, in that they thrive in a diversity of marginal habitats, utilize both aquatic and arboreal habitats, and are members of one of few genera that are …

Reflections On Feminism, Law & Culture: Law Students’ Perspectives, Bridget J. Crawford

Elisabeth Haub School of Law Faculty Publications

This essay is a collective reflection by thirty-nine law students on feminism, law and culture. In the Spring 2020 semester, the students who enrolled in the Feminist Legal Theory course taught by Professor Bridget Crawford at the Elisabeth Haub School of Law at Pace University were a mixed-gender group of second-year, third-year, and fourth-year students. The course focused on the themes and methods of feminist analysis and the application of feminist legal theories to topics such as intimate partner violence, prostitution, pornography, sexual harassment, reproductive rights, and economic rights. Students attended a traditional seminar meeting once each week. Conversations continued …

Development Of Double-Controlled Drug Eluting Stents With Nanotechnology, Brandon Park '21

Student Publications & Research

Due to the limitations or poor drug release kinetics and subsequent damage to adjacent normal digestive epithelial cells for drug eluting stents (DES), this project highlights the usage of gemcitabine-loaded mesoporous silica nanoparticles (gMSNP), which were coated onto a stent with biodegradable poly(lactic-coglycolic) acid (PLGA) polymer. The results showed improved drug release kinetics of the developed nanocomposite layers of the stent. Using our results, our DES will eventually reduce the rate of restenosis that can be induced by stents.

Fall 2020 Som Alumni Connections, New York Medical College

School of Medicine

• Meet the Chair of the Board
• NYMC Welcomes Newest Cohort of Medical Students
• NYMC Enters Academic Affiliation with NYC Health + Hospitals/Lincoln
• $100,000 Gift from Henry Saphier, M.D. '61, Will Support Important COVID-19 Research
• Research on Rapid Diagnostic Test for COVID-19 Underway at NYMC
• NYMC Students Distribute Masks and Good Will with the Mask Transit Project
• NYMC Receives $594K NIH Shared Instrumentation Grant
• Founder's Dinner Brings NYMC Community Together Virtually
• Six COVID-19 Symposiums Have Addressed "What Have We Learned? How Can We Use What We Have Learned?"
• NYMC Hosts Writing Workshop to Empower Students to Use Their Written Voice
• NYMC …

The Honors Beacon, Issue 18, Fall 2020, Honors Program At Minnesota State University, Mankato

Honors Beacon

Fall 2020 newsletter of the Honors Program at Minnesota State University, Mankato.

Wright State University Magazine, Fall 2020, Office Of Marketing, Wright State University, Alumni Association, Wright State University, Wright State University Foundation

Wright State University Magazine

48-page issue of the Wright State Magazine. This magazine is published twice a year and focuses on news related to Wright State alumni, faculty, and friends of the university.

Human Confusion: Why There Must Be Justice For Non-Humans, David Johns

Political Science Faculty Publications and Presentations

Over the last twelve millennia—since agriculture first emerged—humans have increased their exploitation and efforts to control other species and to colonize the Earth. Human on human hierarchy and colonization of other humans follows on the colonization of the natural world. The task of conservation is to undo that colonial relationship. We have been causing the extinction of other life-forms, including hominid species, since we left Africa at least 60,000 years ago. In the last 50 years, or just about two human generations, nearly 68% of all vertebrate animals have disappeared due to human activity (WWF 2020). Humans go into an …

Striving For The Mountaintop: The Elimination Of Health Disparities In A Time Of Retrenchment (1968-2018), Gwendolyn R. Majette

Law Faculty Articles and Essays

Health disparities in the United States are real. People of color are the adverse beneficiaries of these facts-lower life expectancy, higher rates of morbidity and mortality, and poorer health outcomes in general. This Article analyzes the laws and policies that improve and create barriers to improving people of color's health since the death of Reverend Martin Luther King, Jr. in 1968. The Article builds upon my earlier scholarship and considers the effectiveness of the "PPACA Framework to Eliminate Health Disparities" since the Patient Protection and Affordable Care Act (PPACA) was enacted in 2010.

The Article also explores the impact of …

Effect Of Conjugated Estrogens And Bazedoxifene On Glucose, Energy And Lipid Metabolism In Obese Postmenopausal Women, Kara L. Marlatt, Dragana Lovre, Robbie A. Beyl, Chandra R. Tate, Evelyn K. Hayes, Charles F. Burant, Eric Ravussin, Franck Mauvais-Jarvis

Clinical Research Faculty Publications

Objective: Combining conjugated estrogens (CE) with the selective estrogen receptor modulator bazedoxifene (BZA) is a novel, orally administered menopausal therapy. We investigated the effect of CE/BZA on insulin sensitivity, energy metabolism, and serum metabolome in postmenopausal women with obesity. Design: Randomized, double-blind, crossover pilot trial with washout was conducted at Pennington Biomedical Research Center. Eight postmenopausal women (age 50-60 years, BMI 30-40 kg/m2) were randomized to 8 weeks CE/BZA or placebo. Primary outcome was insulin sensitivity (hyperinsulinemic-euglycemic clamp). Secondary outcomes included body composition (DXA); resting metabolic rate (RMR); substrate oxidation (indirect calorimetry); ectopic lipids (1H-MRS); fat cell size, adipose and …

African American Emerging Adult Perspectives On Unintended Pregnancy And Meeting Their Needs With Mobile Technology: Mixed Methods Qualitative Study, Lucy Annang Ingram, Crystal Stafford, Quentin Mccollum, Mckenzie Isreal

Faculty Publications

Background: In the United States, a disproportionate number of unintended pregnancies occur among African Americans, particularly those in their later teenage years and early 20s. Mobile technology is becoming more ubiquitous as a method for health promotion; however, relatively little research has been done with this population to determine their perspectives about unintended pregnancy, the potential of successfully using mobile technology to prevent unintended pregnancy, and the content of such programs.

Objective: The purpose of this study was to obtain the perspectives of African American emerging adults about unintended pregnancy and the use of mobile technology to reduce unintended pregnancy …

Lsu Research Fall 2020, Louisiana State University And Agricultural And Mechanical College

Research Magazine

LSU Research is published annually by the Office of Research & Economic Development, Louisiana State University.

The Case For Re-Examining Glycosylation Inhibitors, Mimetics, Primers And Glycosylation Decoys As Antivirals And Anti-Inflammatories In Covid19, Roger A. Laine

Faculty Publications

No abstract provided.

Montana Native Entomopathogenic Nematode Species Against Limonius Californicus (Coleoptera: Elateridae), Ramandeep Kaur Sandhi, David Shapiro-Ilan, Gadi V.P. Reddy

Faculty Publications

Wireworms are destructive soil inhabiting polyphagous pests in the Pacific Northwest and Intermountain region of the United States. Continuously increasing wireworm populations and damage in small grain crops such as spring wheat in Northern Great Plains has become a challenge for growers. Due to unavailability of effective control measures, alternative methods, including biological control agents such as entomopathogenic nematodes (EPNs) are needed. Native/indigenous EPN species are expected to have better potential than exotic species to control the local insect pests. Two Montana native EPN species (Steinernema feltiae and Heterorhabditis bacteriophora) were tested against, Limonius californicus (Coleoptera: Elateridae) in laboratory and …

A New Twist On The “Un-African” Script: Representing Gay And Lesbian African Weddings In Democratic South Africa, Michael W. Yarbrough

Publications and Research

This essay examines the media coverage surrounding two African weddings of lesbian and gay couples in South Africa, as a lens onto the evolving cultural politics of black queerness in that country. Two decades after South Africa launched a world-leading legal framework for LGBTI protections, I argue that these media representations depict the growing inclusion of black LGBTIQ people as a process of bridging the supposed “gap” between homosexuality and African culture. This new “bridging the gap” script seemingly rejects the older, dominant script portraying homosexuality as intrinsically “un-African.” But I argue that it instead reproduces the “un-African” script in …

Environmentally Clean Access To Antarctic Subglacial Aquatic Environments, Alexander B. Michaud, Trista (Vick-Majors, Amanda M. Achberger, Mark L. Skidmore, Brent C. Christner, Martyn Tranter, John C. Priscu

Faculty Publications

Subglacial Antarctic aquatic environments are important targets for scientific exploration due to the unique ecosystems they support and their sediments containing palaeoenvironmental records. Directly accessing these environments while preventing forward contamination and demonstrating that it has not been introduced is logistically challenging. The Whillans Ice Stream Subglacial Access Research Drilling (WISSARD) project designed, tested and implemented a microbiologically and chemically clean method of hot-water drilling that was subsequently used to access subglacial aquatic environments. We report microbiological and biogeochemical data collected from the drilling system and underlying water columns during sub-ice explorations beneath the McMurdo and Ross ice shelves and …

Reducing Host Dna Contamination In 16s Rrna Gene Surveys Of Anthozoan Microbiomes Using Pna Clamps, Alicia M. Reigel, Sarah M. Owens, Michael E. Hellberg

Faculty Publications

Efforts to study the microbial communities associated with corals can be limited by inefficiencies in the sequencing process due to high levels of host amplification by universal bacterial 16S rRNA gene primers. Here, we develop an inexpensive peptide nucleic acid (PNA) clamp that binds to a target sequence of host DNA during PCR and blocks amplification. We then test the ability of this PNA clamp to mitigate host contamination and increase overall microbial sequence coverage on samples from three coral species: the gorgoniansEunicea flexuosaandGorgonia ventalina,and the scleractinianPorites panamensis. The 20-bp PNA clamp was designed using DNA fromE. flexuosa. Adding the …

Assessment Of Surface Hydrological Connectivity In An Ungauged Multi-Lake System With A Combined Approach Using Geostatistics And Spaceborne Sar Observations, Yueqing Chen, Lili Wu, Guangxin Zhang, Y. Jun Xu, Zhiqiang Tan, Sijia Qiao

Faculty Publications

Connectivity metrics for surface water are important for predicting floods and droughts, and improving water management for human use and ecological integrity at the landscape scale. The integrated use of synthetic aperture radar (SAR) observations and geostatistics approach can be useful for developing and quantifying these metrics and their changes, including geostatistical connectivity function (GCF), maximum distance of connection (MDC), surface water extent (SWE), and connection frequency. In this study, we conducted a geostatistical analysis based on 52 wet and dry binary state (i.e., water and non-water) rasters derived from Sentinel-1 A/B GRD products acquired from 2015 to 2019 for …

Breakfast Skipping And Overweight/Obesity In First Grade Primary School Children: A Nationwide Register-Based Study In Iceland, Anita Aanesen, Peter T. Katzmarzyk, Linda Ernstsen

Population and Public Health Science Faculty Publications

Although several studies have revealed an association between skipping breakfast and overweight (OW) or obesity (OB) in older children and adolescents, less is known about that association in younger children. The purpose of our study was to assess the association between skipping breakfast and OW/OB in children in the first grade. The sample included 4360 children (51.5% boys) aged 5.6 to 7.4 years who participated in the annual health examination in Iceland during 2016 and 2017, completed by 91% of all first graders in Iceland. Binary logistic regression analysis with odds ratios (ORs) and 95% confidence intervals (CIs) was used …

Canadian 24-Hour Movement Guidelines For Adults Aged 18-64 Years And Adults Aged 65 Years Or Older: An Integration Of Physical Activity, Sedentary Behaviour, And Sleep, Robert Ross, Jean Philippe Chaput, Lora M. Giangregorio, Ian Janssen, Travis J. Saunders, Michelle E. Kho, Veronica J. Poitras, Jennifer R. Tomasone, Rasha El-Kotob, Emily C. Mclaughlin, Mary Duggan, Julie Carrier, Valerie Carson, Sebastien F. Chastin, Amy E. Latimer-Cheung, Tala Chulak-Bozzer, Guy Faulkner, Stephanie M. Flood, Mary Kate Gazendam, Genevieve N. Healy, Peter T. Katzmarzyk, William Kennedy, Kirstin N. Lane, Amanda Lorbergs, Kaleigh Maclaren, Sharon Marr, Kenneth E. Powell, Ryan E. Rhodes, Amanda Ross-White, Frank Welsh, Juana Willumsen, Mark S. Tremblay

Population and Public Health Science Faculty Publications

The Canadian Society for Exercise Physiology assembled a Consensus Panel representing national organizations, content experts, methodologists, stakeholders, and end-users and followed an established guideline development procedure to create the Canadian 24-Hour Movement Guidelines for Adults aged 18-64 years and Adults aged 65 years or older: An Integration of Physical Activity, Sedentary Behaviour, and Sleep. These guidelines underscore the importance of movement behaviours across the whole 24-h day. The development process followed the strategy outlined in the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument. A large body of evidence was used to inform the guidelines including 2 de …

Metabolic And Energetic Benefits Of Microrna-22 Inhibition, Marc Thibonnier, Christine Esau, Sujoy Ghosh, Edward Wargent, Claire Stocker

Division of Basic Science Faculty Publications

INTRODUCTION: We previously demonstrated in primary cultures of human subcutaneous adipocytes and in a mouse model of diet-induced obesity that specific microRNA-22-3p antagomirs produce a significant reduction of fat mass and an improvement of several metabolic parameters. These effects are related to the activation of target genes such as KDM3A, KDM6B, PPARA, PPARGC1B and SIRT1 involved in lipid catabolism, thermogenesis, insulin sensitivity and glucose homeostasis. RESEARCH DESIGN AND METHODS: We now report a dedicated study exploring over the course of 3 months the metabolic and energetic effects of subcutaneous administration of our first miR-22-3p antagomir drug candidate (APT-110) in adult …

Exercise Training Impacts Skeletal Muscle Clock Machinery In Prediabetes, Melissa L. Erickson, H. U.I. Zhang, Jacob T. Mey, John P. Kirwan

Division of Basic Science Faculty Publications

Purpose Disruption of the skeletal muscle molecular clock leads to metabolic disease, whereas exercise may be restorative, leading to improvements in metabolic health. The purpose of this study was to evaluate the effects of a 12-wk exercise intervention on skeletal muscle molecular clock machinery in adults with obesity and prediabetes, and determine whether these changes were related to exercise-induced improvements in metabolic health. Methods Twenty-six adults (age, 66 ± 4.5 yr; body mass index (BMI), 34 ± 3.4 kg·m-2; fasting plasma glucose, 105 ± 15 mg·dL-1) participated in a 12-wk exercise intervention and were fully provided isoenergetic diets. Body composition …

Evidence Summaries And Recommendations From The International Evidence-Based Guideline For The Assessment And Management Of Polycystic Ovary Syndrome: Lifestyle Management, Lisa J. Moran, Eliza C. Tassone, Jacqueline Boyle, Leah Brennan, Cheryce L. Harrison, Angelica Lindén Hirschberg, Siew Lim, Kate Marsh, Marie L. Misso, Leanne Redman, Mala Thondan, Chandrika Wijeyaratne, Rhonda Garad, Nigel K. Stepto, Helena J. Teede

Clinical Research Faculty Publications

Lifestyle is fundamental in chronic disease prevention and management, and it has been recommended as a first-line treatment in the Australian polycystic ovary syndrome (PCOS) guideline 2011. The first international evidence-based guideline on PCOS was developed in 2018, which expanded the scope and evidence in the Australian guideline. This paper summarizes the lifestyle recommendations and evidence summaries from the guideline. International multidisciplinary guideline development groups delivered the International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome 2018. The process followed the Appraisal of Guidelines for Research and Evaluation II and The Grading of Recommendations, Assessment, Development and …

Quantifying Expert Opinion With Discrete Choice Models: Invasive Elodea's Influence On Alaska Salmonids, Joseph Little, Gregory D. Hayward

ISER Articles

Scientific evidence should inform environmental policy, but rapid environmental change brings high ecological uncertainty and associated barriers to the science-management dialogue. Biological invasions of aquatic plants are a worldwide problem with uncertain ecological and economic consequences. We demonstrate that the discrete choice method (DCM) can serve as a structured expert elicitation alternative to quantify expert opinion across a range of possible but uncertain environmental outcomes. DCM is widely applied in the social sciences to better understand and predict human preferences and trade-offs. Here we apply it to Alaska's first submersed invasive aquatic freshwater plant, Elodea spp. (elodea), and its unknown …

2020 Fall Nutshell, Morehead State University. Institutional Research & Analysis.

Office of Institutional Research & Analysis Publication Archive

Fall 2020 issue of the Nutshell.

A Preliminary Look Into Regional Primary Succession In The Depauw University Nature Park Quarry, Sophia Atkinson, Diana Borse, Dana Dudle

Annual Student Research Poster Session

Quarries are anthropogenic landscapes that when abandoned, leave a blank slate in the environment for species to come in and repopulate the area. This gives way to primary succession, a process that re-vegetates areas devoid of soil. The goal of this research is to investigate where the abandoned limestone quarry at the DePauw University Nature Park is in terms of its successional phase since extraction stopped in 1977. Throughout the summer of 2020, plant species were identified along with the specific region and sub-habitat, the main sub-habitats being the temporary ponds, quarry spoils, talus slopes, flat limestone areas, and damp …

Tools For Genotyping Of Nicotine-Seeking Zebrafish, Emma Kennedy, Aziza Shemet Pitcher, Sabrina Krause, Autumn Mcdaniel, Molly Ruggles, Henning Schneider

Annual Student Research Poster Session

Smoking is one of the main causes of preventable diseases such as cancer, cardiovascular diseases, diabetes, and chronic obstructive pulmonary disease. Helping people quit using nicotine products is a main goal of our projects. Developing a zebrafish model for nicotine use behavior could provide a tool for studying the underlying genetic risks and neuronal elements of nicotine use behavior. The availability of large numbers of larval zebrafish, relatively short generation time and genetic tools present a major advantage for studying the genetic causes of nicotine use behavior. Here, we present our approach to test whether identified single nucleotide polymorphisms (SNPs) …

Antibiotic Resistance And Variability In The Physiological Profiles Of Streambed Bacterial Communities: Implication Of Wastewater Treatment Plant Effluents, Madeline Draper, Amerti Guta, Philips Akinwole

Annual Student Research Poster Session

The effluents of wastewater treatment plants (WWTPs) include a complex mixture of nutrients and toxic substances, thus, the potential exists for the effluent to significantly impact the biochemical characteristics and bacterial communities of the receiving freshwater ecosystem. Our findings highlight the worrisome impacts of WWTPs on microbial biomass, coliform forming units, bacterial metabolic diversity, and antibiotic resistance patterns on the receiving water. In this study, microbial biomass and coliform forming units were significantly higher at the WWTP outfall compared to the reference site. Furthermore, this report revealed significant differences in the composition of bacterial communities in the context of WWTP …

Hsa-Mir-4520-2-3p: A Potential Modulator Of Covid-Related Ace2, Molly Ruggles, Nipun Chopra

Annual Student Research Poster Session

ACE2 is a transmembrane receptor located in cells in various tissues around the body. Its normal role is the conversion of Angiotensin II to Angiotensin 1-7 leading to vasodilation and a subsequent reduction in blood pressure via the renin-angiotensin-aldosterone system. ACE2 also plays a pivotal role in the infection of COVID-19 as it determines entry of virus into human cells. SARS-CoV-2 uses one of its four structural proteins, the spike (S) glycoprotein, to bind to the ACE2 receptor. This entry into the cell begins the process of infection and spread of the disease; because of the abundance of ACE2 throughout …

Cardiac Neuroanatomy And Chronotropic Modulation Of The Adult Giant Danio Heart, Alyssa Koch, Emma Nelson, Pascal Lafontant

Annual Student Research Poster Session

Studies in non-mammalian models species have contributed significantly to our understanding of the biology and the nature of innervation in the heart. The giant danio (D. malabaricus) is a teleost fish species closely related to zebrafish, that is also capable of heart regeneration. We previously described the development and maturation of the giant danio (GD) heart. However, little is known about its innervation. We hypothesized that the pattern of innervation in the GD heart is anatomically and physiologically complex, and that the heart is responsive to physiological modulation similar to that seen in cyprinid fish and mammals. Using various neuronal …