Digital Commons Network^™

Alternative Treatments To Koalas With Chlamydia, Kelsey Thornton

Fall Showcase for Research and Creative Inquiry

Koala populations have declined rapidly in the past 2 decades due to many reasons such as disease, vehicle collisions, dog attacks, urbanization and deforestation, and climate-related issues. Chlamydia is one of the leading causes for population declines in koalas. Koalas are difficult to treat for chlamydia because antibiotic treatment kills the specialized gut bacteria they have and need for degrading toxic compounds within eucalyptus leaves, their only source of food. I propose that doxycycline, a drug with a 97% cure rate and reduced dysbiosis, to be administered at higher concentrations less frequently. Additionally, I propose that koalas treated with antibiotics …

Combining Treatments For Opioid Addictions, Raquel Perez

Fall Showcase for Research and Creative Inquiry

  In 2018 the National Survey of Drug Use and Health reported that 9.9 million people misused prescription pain relievers out of 10.3 million who reported using opioids. Opioid abuse has grown from just being considered a medical dilemma, it has clearly become a social and economic issue (Eaton and Vettese, 2020). This proposal will be investigating the combination of pre-existing pharmacological treatments and support group therapy. This is not a new concept however because of the nature of opioid addictions having severe withdrawal symptoms most treatments are primarily medication base. Drug addictions have been known to carry a negative stigma …

The Grizzly, October 1, 2020, Simra Mariam, Gillian Mccomeskey, Kevin Melton, Layla Halterman, Shelsea Deravil, Julia Paiano, Rosalia Murphy, Ava Compagnoni

Ursinus College Grizzly Newspaper, 1978 to Present

In Memoriam: Aidan Inteso '24 • Ursinus Receives National Ranking • Autumn at Ursinus • Ursinus Online: New Ways to Live Together • A Powerful Yet Stylish Weapon • Opinion: Online Learning Versus In-Tents Perspective; Ursinus Response to COVID-19 • Closeness of Teammates Under COVID-19 Guidelines • Back to Practice: COVID Style

Complaint, Milena Sterio, Diane Marie Amann, Margaret Deguzman, Gabor Rona

Law Faculty Briefs and Court Documents

On June 11, 2020, President Donald J. Trump issued Executive Order 13,928, Blocking Property of Certain Persons Associated With the International Criminal Court, threatening severe sanctions, monetary penalties, and imprisonment on persons who assist the International Criminal Court (ICC). The Executive Order exceeds its legal authority, impermissibly prohibits speech, and fails to provide notice as to who it covers and what for what activities.

Those impacted by the Executive Order include U.S. persons, including U.S. entities, as well as foreign persons and foreign entities. The Open Society Justice Initiative and four law professors, all of whom have engaged extensively …

A Thorough Analysis And Categorization Of Bacterial Interrupted Adenylation Domains, Including Previously Unidentified Families, Taylor A. Lundy, Shogo Mori, Sylvie Garneau-Tsodikova

Pharmaceutical Sciences Faculty Publications

Interrupted adenylation (A) domains are key to the immense structural diversity seen in the nonribosomal peptide (NRP) class of natural products (NPs). Interrupted A domains are A domains that contain within them the catalytic portion of another domain, most commonly a methylation (M) domain. It has been well documented that methylation events occur with extreme specificity on either the backbone (N-) or side chain (O- or S-) of the amino acid (or amino acid-like) building blocks of NRPs. Here, through taxonomic and phylogenetic analyses as well as multiple sequence alignments, we evaluated the similarities and …

External Funding Bulletin, July - December 2020, Uno Office Of Research And Creative Activity

Sponsored Programs Bulletins

This bulletin features recent award recipients.

Family Law—Breach Baby: An Argument For Equal Enforcement Of Traditional And Gestational Surrogacy Contracts, James M. Gift

University of Arkansas at Little Rock Law Review

No abstract provided.

Grains, Seeds And Hay Industry Funding Scheme Annual Report 2019/2020, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity published reports

The Grains, Seeds and Hay Industry Funding Scheme (IFS) has been operating since 2010 to address biosecurity threats relevant to Western Australia’s (WA) grains, seeds and hay industry. The Scheme was established under the Biosecurity and Agriculture Management Act 2007 to enable growers to identify the pest and disease priorities at a whole-of-industry level and raise funds for activities to address these priorities.

There are currently three Industry Funding Schemes in operation. In addition to the Grains, Seeds and Hay IFS, there is a Cattle IFS and a Sheep and Goat IFS. The three IFSs operate in a similar manner. …

Library Newsletter, Volume 16, Issue 1, Sacred Heart University Library

Library Newsletters

Word from the Stacks ... Staying the Course: Library Services During the COVID-19 Pandemic --Library Resources: New Resources Trials and Choices in the All-Online Environment --Anti-Racist and Diverse Voices at the Library --Books That Have Kept Us Sane During Trying Times.

Promise - Fall 2020, The University Of Texas Md Anderson Cancer Center

Promise: A Publication for Friends of MD Anderson

• 12-year-old osteosarcoma patient supports cancer research, spreads hope
• LyondellBasell returns as presenting sponsor of Boot Walk to End Cancer
• Delia Stroud leads team in fundraising for virtual Boot Walk to End Cancer
• Peter WT Pisters, M.D., receives James Ewing Lecturer Award
• Artwork fetches $11,000 in virtual action for cancer research
• Mantle cell lymphoma patient pledges $500,000 to personalized therapy clinical trial
• Small gifts lead to big impact
• Giving supports virtual programming for young cancer patients
• 15-year-old hosts birthday fundraiser for childhood cancer patients
• Get to know Advance Team member Jessica Ramsey
• Monica Johnson receives Julie and Ben Rogers Award for …

Nguyễn An Ninh’S Anti-Colonial Thought: A New Account Of National Shame, Kevin D. Pham

Political Science Faculty Publications

A source of national shame can be the perception that one’s nation is intellectually inferior to other nations. This kind of national shame can lead not to despair but to a sense of national responsibility to engage in creative self-renewal and to create national identity from scratch. An exemplar of someone who recognized and engaged with this kind of national shame is Nguyễn An Ninh (1900–1943), an influential Vietnamese anti-colonial intellectual in French colonial Vietnam. Ninh’s account of national shame challenges existing assumptions in political theory, namely that national identity requires national pride, that national shame comes from bad actions …

A Comparison Of Invasive And Native Plants In An Abandoned Limestone Quarry, Diana Borse, Sophia Atkinson, Dana Dudle

Annual Student Research Poster Session

The abandoned limestone quarry in the DePauw Nature Park is a site of interest for research into plant community establishment due to the harsh, heterogenous, and fluctuating environment. Because the limestone floor of the quarry is a novel anthropogenic environment, every plant species in the quarry had to be introduced somehow. Perhaps native species that are able to establish populations in the quarry are more likely to share traits with invasive species. Using information collected from scientific articles, I compared traits of three pairs of plants with similar forms to compare their life history traits to see if any patterns …

Balancing Benefits And Harms Of Sexual Orientation And Gender Identity Genomics Research: Legal And Life Implications, Lisa E. Smilan

University of Baltimore Law Review

No abstract provided.

Growing Up In Prison: Rethinking Juvenile Offender Parole Hearings To Eliminate Essential Life Sentences, Jenna Mcgreevy

University of Baltimore Law Review

No abstract provided.

Interleukin 35 Delays Hindlimb Ischemia-Induced Angiogenesis Through Regulating Ros-Extracellular Matrix But Spares Later Regenerative Angiogenesis., Hangfei Fu, Yu Sun, Ying Shao, Jason Saredy, Ramon Cueto, Lu Liu, Charles Drummer, Candice Johnson, Keman Xu, Yifan Lu, Xinyuan Li, Shu Meng, Eric R Xue, Judy Tan, Nirag C Jhala, Daohai Yu, Yan Zhou, Kayla J Bayless, Jun Yu, Thomas J Rogers, Wenhui Hu, Nathaniel W Snyder, Jianxin Sun, Xuebin Qin, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

Center for Translational Medicine Faculty Papers

Interleukin (IL) 35 is a novel immunosuppressive heterodimeric cytokine in IL-12 family. Whether and how IL-35 regulates ischemia-induced angiogenesis in peripheral artery diseases are unrevealed. To fill this important knowledge gap, we used loss-of-function, gain-of-function, omics data analysis, RNA-Seq, in vivo and in vitro experiments, and we have made the following significant findings: i) IL-35 and its receptor subunit IL-12RB2, but not IL-6ST, are induced in the muscle after hindlimb ischemia (HLI); ii) HLI-induced angiogenesis is improved in Il12rb2-/- mice, in ApoE-/-/Il12rb2-/- mice compared to WT and ApoE-/- controls, respectively, where hyperlipidemia inhibits angiogenesis in vivo and in …

Stxbp2-R190c Variant In A Patient With Neonatal Hemophagocytic Lymphohistiocytosis (Hlh) And G6pd Deficiency Reveals A Critical Role Of Stxbp2 Domain 2 On Granule Exocytosis, Nathalia Benavides, Waldo A Spessott, Maria L Sanmillan, Marcelo Vargas, Mylynda S Livingston, Nissa Erickson, Tamara C Pozos, Margaret E Mccormick, Emilia Scharrig, Yoav H Messinger, Claudio G. Giraudo

Department of Microbiology and Immunology Faculty Papers

Neonatal hemophagocytic lymphohistiocytosis (HLH) is a medical emergency that can be associated with significant morbidity and mortality. Often these patients present with familial HLH (f-HLH), which is caused by gene mutations interfering with the cytolytic pathway of cytotoxic T-lymphocytes (CTLs) and natural killer cells. Here we describe a male newborn who met the HLH diagnostic criteria, presented with profound cholestasis, and carried a maternally inherited heterozygous mutation in syntaxin-binding protein-2 [STXBP2, c.568C>T (p.Arg190Cys)] in addition to a severe pathogenic variant in glucose 6-phosphate dehydrogenase [G6PD, hemizygous c.1153T>C (Cys385Arg)]. Although mutations in STXBP2 gene are …

Nipple Sparing Mastectomy: A Review Of Outcomes At A 1 Single Institution, Steven Woodward, Md, Alliric Willis, Melissa Lazar, Adam C. Berger, Theodore Tsangaris

Department of Surgery Faculty Papers

Introduction

Nipple sparing mastectomy (NSM) offers patients who are not candidates for breast conserving treatment an aesthetically pleasing alternative to traditional mastectomy. Some studies have demonstrated its oncologic safety while others have demonstrated residual occult tumor cells at the nipple areolar complex (NAC). These data prompt further review of oncologic outcomes after NSM.

Methods

A single institution retrospective chart review of all NSMs performed by 4 breast surgeons at Thomas Jefferson University Hospital over a span of 2012-2019. In this cohort we review the reconstruction performed, axillary lymph node status, surgical margins, final pathology, loss of the NAC, recurrence rates, …

Toward A Theory Of Intercountry Human Rights: Global Capitalism And The Rise And Fall Of Intercountry Adoption, Barbara Stark

Indiana Law Journal

This Article proposes another mechanism for enforcement, an alternative to self-serving domestic policing and weak international bureaucracy. “Intercountry,” as opposed to “international,” human rights would apply to specific rights in specific contexts and be enforceable through the legal mechanisms and other resources of the state parties that accepted them. Intercountry adoption is a useful context in which to consider this proposal for several reasons.

First, as a practical matter, there have probably never been more babies and children in orphanages, on the street, on the market, or on their own. Yet intercountry adoptions have declined to levels not seen for …

Tccy Ombudsman Program Annual Report Fy 2019-2020, Tennessee. Commission On Children And Youth.

Ombudsman Program Annual Report

No abstract provided.

Association Between Stress And Length Of Program In Underrepresented Minority Physician Assistant Students, Michelle Mcweeney, Michelle Mcweeney

Seton Hall University Dissertations and Theses (ETDs)

Abstract

The purpose of this study was to determine if there was a relationship between physician Assistant (PA) program length and stress measures in PA students, particularly PA students classified as underrepresented minorities in medicine. The stress measures included in this study were quality of life, mental well-being, emotional well-being, and physical well-being. Previous studies in PA education have examined the effect of PA program length on national certifying exam pass rates and have shown no relationship between the two. This was the first study examining the relationship between PA program length and stress measures. There is a documented lack …

Staying Connected – Interactive Student Learning During The Covid Transition To Remote Learning, Jeffrey A. Starke, Margaret L. Mcnamara, Richard J. Povinelli, Daniela Castillo-Perez, Linda Noelle Brigham

Civil and Environmental Engineering Faculty Research and Publications

Background.

How can we transition courses in one week, while maintaining a similar experience for students? This was probably the initial response by faculty across universities as they transitioned to remote learning, mid-semester, in response to the SARS-CoV-2 pandemic. Our approach is supported by the ICAP framework which posits that “as activities move from passive to active to constructive to interactive, students undergo different knowledge-change processes and, as a result, learning will increase.” (Chi and Wylie, 2014)

Purpose/Hypothesis.

How we could foster students’ interactions with course material, instructors, and their peers using collaborative technology and course activities? It was hypothesized …

Fibroblast Encapsulation In Gelatin Methacryloyl (Gelma) Versus Collagen Hydrogel As Substrates For Oral Mucosa Tissue Engineering, Fahimeh Tabatabaei, Keyvan Moharamzadeh, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Purpose

Over the past decades, a variety of biomaterials have been investigated in terms of their suitability for oral mucosa tissue engineering. The aim of this study was to compare collagen and GelMA hydrogels as connective tissue scaffolds for fibroblasts and as substrates for seeding and culture of oral epithelial keratinocyte cells.

Methods

Human primary oral fibroblast and keratinocyte cells were isolated from gingival biopsies. The mixture of fibroblasts with GelMA or collagen gel were aliquoted within six-well tissue culture plate inserts and cross-linked using visible light or reconstitution buffer/heat, respectively. The viability of fibroblasts in the hydrogels was investigated …

Three-Dimensional In Vitro Oral Mucosa Models Of Fungal And Bacterial Infections, Fahimeh Tabatabaei, Keyvan Moharamzadeh, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Oral mucosa is the target tissue for many microorganisms involved in periodontitis and other infectious diseases affecting the oral cavity. Three-dimensional (3D) in vitro and ex vivo oral mucosa equivalents have been used for oral disease modeling and investigation of the mechanisms of oral bacterial and fungal infections. This review was conducted to analyze different studies using 3D oral mucosa models for the evaluation of the interactions of different microorganisms with oral mucosa. In this study, based on our inclusion criteria, 43 articles were selected and analyzed. Different types of 3D oral mucosa models of bacterial and fungal infections were …

Incremental Prognostic Value Of A Novel Metabolite-Based Biomarker Score In Congestive Heart Failure Patients, Peter Mcgranaghan, Anshul Saxena, Muni Rubens, Joseph Salami, Emir Veledar

All Publications

Aims: The Cardiac Lipid Panel (CLP) is a newly discovered panel of metabolite-based biomarkers that has shown to improve the diagnostic value of N terminal pro B type natriuretic peptide (NT-proBNP). However, little is known about its usefulness in predicting outcomes. In this study, we developed a risk score for 4-year cardiovascular death in elderly chronic heart failure (CHF) patients using the CLP.

Methods and results: From the Cardiac Insufficiency Bisoprolol Study in Elderly trial, we included 280 patients with CHF aged >65 years. A targeted metabolomic analysis of the CLP biomarkers was performed on baseline serum samples. Cox regression …

Children’S Ethno-National Flag Categories In Three Divided Societies, Edona Maloku, Jocelyn B. Dautel, Ana Tomovska Misoska, Laura K. Taylor

Articles

Flags are conceptual representations that can prime nationalism and allegiance to one’s group. Investigating children’s understanding of conflict-related ethno-national flags in divided societies sheds light on the development of national categories. We explored the development of children’s awareness of, and preferences for, ethno-national flags in Northern Ireland, Kosovo, and the Republic of North Macedonia. Children displayed early categorization of, and ingroup preferences for, ethno-national flags. By middle-childhood, children’s conflict-related social categories shaped systematic predictions about other’s group-based preferences for flags. Children of minority-status groups demonstrated more accurate flag categorization and were more likely to accurately infer others’ flag preferences. While …

Physics For Everyone, Charles Liu, Sarang Gopalakrishnan, Vadim Oganesyan

Open Educational Resources

The online educational resource Physics For Everyone is the scaffolding for a 3 contact hour, 3 credit general education course that will be offered for the first time at the CUNY College of Staten Island in the spring semester of 2021. This work has been generously supported by New America’s PIT-UN (Public Interest Technology University Network) challenge grant program, and is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.

This slide deck provides the outline for the semester-long course. Each week’s lecture topics, with key points to be covered, are highlighted in two slides, which also list writing prompts, …

Identifying And Validating Subtypes Within Major Psychiatric Disorders Based On Frontal-Posterior Functional Imbalance Via Deep Learning, Miao Chang, Fay Y Womer, Xiaohong Gong, Weixiong Zhang, Et Al

Open Access Publications

Converging evidence increasingly implicates shared etiologic and pathophysiological characteristics among major psychiatric disorders (MPDs), such as schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD). Examining the neurobiology of the psychotic-affective spectrum may greatly advance biological determination of psychiatric diagnosis, which is critical for the development of more effective treatments. In this study, ensemble clustering was developed to identify subtypes within a trans-diagnostic sample of MPDs. Whole brain amplitude of low-frequency fluctuations (ALFF) was used to extract the low-dimensional features for clustering in a total of 944 participants: 581 psychiatric patients (193 with SZ, 171 with BD, and 217 …

Water Current, Volume 52, No. 3, Fall 2020

Water Current Newsletter

NWC Convenes August 3 Mini-Conference

Water and Public Safety

University Receives $5 million Gift to Create Program on Water, Climate and Health

The Patent Bar Gender Gap: Expanding The Eligibility Requirements To Foster Inclusion And Innovation In The U.S. Patent System, Mary T. Hannon

IP Theory

No abstract provided.

Loma Linda Nurse - Vol. 28, Loma Linda University School Of Nursing

Loma Linda Nurse

FEATURES

4 | Faces of the Frontlines

12 | The COVID Effect

16 | Far and Away—Gabriele Stevens

18 | Leveling Up— A View of the Future

LLUSN HIGHLIGHTS

20-27 | ALUMNI NEWS

28-31 | HOMECOMING

32-35 | ACADEMICS

36-43 | FACULTY UPDATES