Digital Commons Network^™

Fully Inkjet-Printed Multilayered Graphene-Based Flexible Electrodes For Repeatable Electrochemical Response, Twinkle Pandhi, Kiyo Fujimoto, Pete Barnes, Jasmine Cox, Hui Xiong, Paul H. Davis, Harish Subbaraman, David Estrada

Materials Science and Engineering Faculty Publications and Presentations

Graphene has proven to be useful in biosensing applications. However, one of the main hurdles with printed graphene-based electrodes is achieving repeatable electrochemical performance from one printed electrode to another. We have developed a consistent fabrication process to control the sheet resistance of inkjet-printed graphene electrodes, thereby accomplishing repeatable electrochemical performance. Herein, we investigated the electrochemical properties of multilayered graphene (MLG) electrodes fully inkjet-printed (IJP) on flexible Kapton substrates. The electrodes were fabricated by inkjet printing three materials – (1) a conductive silver ink for electrical contact, (2) an insulating dielectric ink, and (3) MLG ink as the sensing material. …

Sure 2020 Undergraduate Science Conference Booklet, Sure Network

Group Reports

The SURE 2020 Conference was the third series of Science Undergraduate Research Experience (SURE) Conferences, following earlier series in 2018 (with three conferences in Dublin, Athlone and Waterford) and in 2019 (with three conferences in Dublin, Sligo and Carlow). The 2020 online conference had a total of 24 oral presentations and 35 poster presentations, and was attended by over 450 students, academic staff, professional body and industry representatives.

The aims of the conference were to:

1. Provide current students with an opportunity to gain an understanding of the work which has been undertaken by recent graduates, and the career opportunities that …

Video-Based Gait Analysis For Health Monitoring, Xinyi Liu

Theses and Dissertations

Human gait is essential for long-term health monitoring as it reflects physical and neurological aspects of a person's health status. In this thesis, we proposed a non-invasive video-based gait analysis system to detect abnormal gait, and record gait and postural parameters on a day-to-day basis. The system does not require subjects to wear any sensors or attach markers on their body, therefore it is convenient to use in daily life. It takes videos captured from a single camera as input. OpenPose is used to localize skeleton and joints in each frame. Angles of body parts form multivariate time series. Then …

A Detailed Assessment Of Groundwater Quality In The Kabul Basin, Afghanistan, And Suitability For Future Development, Hussain Ali Jawadi, Jay Sagin, Daniel D. Snow

Nebraska Water Center: Faculty Publications

Abstract: Kabul is one of the most populated cities in Afghanistan and providing resources to support this population in an arid climate presents a serious environmental challenge. The current study evaluated the quality of local Kabul Basin groundwater to determine its suitability water for drinking and irrigation purposes now and into the future. This aim was aided through groundwater parameter assessment as well as determination ofWater Quality Index (WQI) developed from 15 observation points near the city. The results of our physicochemical analysis illustrate that groundwater in the majority of areas of the Kabul Basin is not generally suitable for …

Bruce Gates: A Career In Catalysis, Cawas Cooper, Kerry M. Dooley, Juan C. Fierro-Gonzalez, Javier Guzman, Rolf Jentoft, H. Henry Lamb, Isao Ogino, Ron C. Runnebaum, Ajit Sapre, Alper Uzun

Faculty Publications

On the occasion of his 80th birthday, we take stock of the remarkable and ongoing career of Professor Bruce C. Gates. This Account highlights his key scientific achievements in three areas of significance: supported metal clusters and atomically dispersed metal complexes, hydroprocessing reaction networks and catalysts, and strong acid catalysis. His contributions in all three areas are noteworthy and have been sustained over 50 years. The work of his group evolved from mainly catalyst synthesis and reaction studies to also incorporate sophisticated characterization techniques based on X-ray absorption spectroscopies and improved scanning transmission electron microscopic examination of catalytic surfaces. In …

Effects Of Housing System On Dairy Heifer Replacement Cost From Birth To Calving: Evaluating Costs Of Confinement, Dry-Lot, And Pasture-Based Systems And Their Impact On Total Rearing Investment, Anna Catherine Hawkins, Kenneth H. Burdine, Donna M. Amaral-Phillips, Joao H. C. Costa

Animal and Food Sciences Faculty Publications

Replacement heifer rearing is critical for the future of dairy operations, to improve genetic merit and maintain herd size. A myriad of options exist on how to manage, feed, and ultimately raise replacement heifers. Pasture is perceived to offer optimal welfare and an economical housing system for replacement animals, but confinement systems are gaining popularity. This study investigates the costs associated with replacement heifer management decisions from birth to calving, considering the factors of housing systems, labor, feed, and health. The objective of this study was to develop an economic model to determine the cost of raising a replacement heifer …

Structured Risk: Black Women, Perceived Integration Into Campus Hook-Up Culture, And The Potential For Sexually-Transmitted Infection Diagnoses At A Predominately White College, Jasmine L. Harris

Sociology Between the Gaps: Forgotten and Neglected Topics

No abstract provided.

A High-Stringency Blueprint Of The Human Proteome., Subash Adhikari, Edouard C Nice, Eric W Deutsch, Lydie Lane, Gilbert S Omenn, Stephen R Pennington, Young-Ki Paik, Christopher M Overall, Fernando J Corrales, Ileana M Cristea, Jennifer E Van Eyk, Mathias Uhlén, Cecilia Lindskog, Daniel W Chan, Amos Bairoch, James C Waddington, Joshua L Justice, Joshua Labaer, Henry Rodriguez, Fuchu He, Markus Kostrzewa, Peipei Ping, Rebekah L Gundry, Peter Stewart, Sanjeeva Srivastava, Sudhir Srivastava, Fabio C S Nogueira, Gilberto B Domont, Yves Vandenbrouck, Maggie P Y Lam, Sara Wennersten, Juan Antonio Vizcaino, Marc Wilkins, Jochen M Schwenk, Emma Lundberg, Nuno Bandeira, Gyorgy Marko-Varga, Susan T Weintraub, Charles Pineau, Ulrike Kusebauch, Robert L Moritz, Seong Beom Ahn, Magnus Palmblad, Michael P Snyder, Ruedi Aebersold, Mark S Baker

Articles, Abstracts, and Reports

The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome …

Associations Of Dietary Bioactive Compounds With Maternal Adiposity And Inflammation In Gestational Diabetes: An Update On Observational And Clinical Studies, Dustin W. Davis, Jeannette Crew, Petar Planinic, James M. Alexander, Arpita Basu

School of Medicine Faculty Research

Gestational diabetes mellitus (GDM) is a common complication of pregnancy that adversely affects maternal and offspring health. Maternal obesity, oxidative stress, and inflammation have been implicated in GDM. In non-pregnant adults, intakes of dietary bioactive compounds inversely associate with insulin resistance and inflammation. However, associations of dietary bioactive compounds with biomarkers of adiposity, antioxidant vitamin and mineral status, oxidative stress, and inflammation in GDM have not been fully elucidated. We addressed this gap by conducting a semi-quantitative review of observational studies and randomized controlled trials published between 2010 and 2020 and retrieved from Google Scholar, Medline, and PubMed. Our analysis …

Protein Arginine Methyltransferase Prmt5 Regulates Fatty Acid Metabolism And Lipid Droplet Biogenesis In White Adipose Tissues, Zhihao Jia, Feng Yue, Xiyue Chen, Naagarajan Narayanan, Jiamin Qiu, Sabriya A. Syed, Anthony N. Imbalzano, Meng Deng, Peng Yu, Changdeng Hu, Shihuan Kuang

Purdue University Libraries Open Access Publishing Fund

The protein arginine methyltransferase 5 (PRMT5) is an emerging regulator of cancer and stem cells including adipogenic progenitors. Here, a new physiological role of PRMT5 in adipocytes and systemic metabolism is reported. Conditional knockout mice were generated to ablate the Prmt5 gene specifically in adipocytes (Prmt5AKO). The Prmt5AKO mice exhibit sex- and depot-dependent progressive lipodystrophy that is more pronounced in females and in visceral (than subcutaneous) white fat. The lipodystrophy and associated energy imbalance, hyperlipidemia, hepatic steatosis, glucose intolerance, and insulin resistance are exacerbated by high-fat-diet. Mechanistically, Prmt5 methylates and releases the transcription elongation factor SPT5 from Berardinelli-Seip congenital lipodystrophy …

Hybrid Breeding For Restoration Of Threatened Forest Trees: Evidence For Incorporating Disease Tolerance In Juglans Cinerea, Andrea N. Brennan, James R. Mckenna, Sean M. Hoban, Douglass F. Jacobs

Purdue University Libraries Open Access Publishing Fund

Hybridization is a potential tool for incorporating stress tolerance in plants, particularly to pests and diseases, in support of restoration and conservation efforts. Butternut (Juglans cinerea) is a species for which hybridization has only recently begun being explored. This North American hardwood tree is threatened due to Ophiognomonia clavigignenti-juglandacearum (Ocj), the causal fungus of butternut canker disease (BCD), first observed in 1967. Observational evidence in some wild J. cinerea populations indicates that naturalized hybrids of J. cinerea with Japanese walnut (Juglans ailantifolia) may be more tolerant to BCD than non-admixed J. cinerea, but this has not been formally tested in …

Graphene-Based Electrochemical Aptasensor For The Detection Of Salmonella Typhimurium, Shalini Muniandy

Student Works (2020-2029)

Recent foodborne outbreaks in multiple locations necessitate the continuous development of highly sensitive and specific biosensors that offer rapid and sensitive detection of foodborne pathogens. The emergence of electrochemical aptasensor which is a compact analytical device with a combination of an aptamer as the biorecognition element integrated on the transducer surface created a breakthrough in the detection of foodborne bacterial pathogens. Graphene has emerged as a promising nanomaterial for reliable detection of pathogenic bacteria due to its exceptional properties such as high electrical conductivity, large surface to volume ratio, high mechanical strength and its unique interactions with DNA bases of …

Role Of Ceramide-1 Phosphate In Regulation Of Sphingolipid And Eicosanoid Metabolism In Lung Epithelial Cells, Brittany A. Dudley

USF Tampa Graduate Theses and Dissertations

Ceramide 1-Phosphate (C1P) is a sphingolipid metabolite which plays a large role in inflammation, cell survival and proliferation¹. C1P is known to have both pro- and anti-apoptotic roles in lung cancer cells, governed by ceramide kinase (CERK), upstream of precursor ceramide (Cer)². Previous work reveals C1P serves as the liaison between sphingolipid and eicosanoid synthesis, by decreasing the dissociation rate of group IVA cytosolic PLA₂ (cPLA_2α) from the Golgi membrane, C1P directly activates this phospholipase for downstream eicosanoid synthesis and subsequent inflammatory response³. CERK has been discovered to modulate eicosanoid synthesis, …

Loss Of Heat Acclimation Capacity Could Leave Subterranean Specialists Highly Sensitive To Climate Change, S. Pallarés, R. Colado, M Botella‐Cruz, A. Montes, P Balart‐García, D. T. Bilton, A. Millán, I. Ribera, D Sánchez‐Fernández

School of Biological and Marine Sciences

No abstract provided.

Computational Modeling Analysis Of Generation Of Reactive Oxygen Species By Mitochondrial Assembled And Disintegrated Complex Ii., Nikolay I. Markevich, Lubov N. Markevich, Jan B. Hoek

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Reactive oxygen species (ROS) function as critical mediators in a broad range of cellular signaling processes. The mitochondrial electron transport chain is one of the major contributors to ROS formation in most cells. Increasing evidence indicates that the respiratory Complex II (CII) can be the predominant ROS generator under certain conditions. A computational, mechanistic model of electron transfer and ROS formation in CII was developed in the present study to facilitate quantitative analysis of mitochondrial ROS production. The model was calibrated by fitting the computer simulated results to experimental data obtained on submitochondrial particles (SMP) prepared from bovine and rat …

Chimes: October 16, 2020, Calvin University

Chimes

Pence rallies in RG: "The road to victory runs right through Michigan" by Katherine Benedict

Supply chain disruptions force Dining Services to adapt by Alex Raycroft

Women in science celebrate Nobel Prize milestone, critique male-dominated field by Sarah Gibes

Calvin top five in state for student loan repayment by Harm Venhuizen

Tutoring services continue online, maintain numbers even during pandemic by Susannah Epp

Calvin's Crossing vandalized over summer, repairs underway by Lauren Vanden Bosch

Jubilee Fellows offers opportunities for students interested in ministry by Michaela Giovannelli

A faith and nation fractured: Prof. Kristin Du Mez reflects on book reception and …

Antioxidant Carbon Nanoparticles Inhibit Fibroblast-Like Synoviocyte Invasiveness And Reduce Disease Severity In A Rat Model Of Rheumatoid Arthritis, Mark R Tanner, Redwan Huq, William K A Sikkema, Lizanne G Nilewski, Nejla Yosef, Cody Schmitt, Carlos P Flores-Suarez, Arielle Raugh, Teresina Laragione, Pércio S Gulko, James M Tour, Christine Beeton

Faculty, Staff and Students Publications

Reactive oxygen species have been involved in the pathogenesis of rheumatoid arthritis (RA). Our goal was to determine the effects of selectively scavenging superoxide (O2•−) and hydroxyl radicals with antioxidant nanoparticles, called poly(ethylene glycol)-functionalized hydrophilic carbon clusters (PEG-HCCs), on the pathogenic functions of fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA) and on the progression of an animal model of RA. We used human FLS from patients with RA to determine PEG-HCC internalization and effects on FLS cytotoxicity, invasiveness, proliferation, and production of proteases. We used the pristane-induced arthritis (PIA) rat model of RA to assess the benefits of …

Music Listening, Music Recreation, And Music Therapy: Effective Implementation In Dementia Care, Laura Cribb Todd

Center for Social Gerontology Community Conference (2017-2022)

In recent years, music has increasingly been acknowledged as an effective nonpharmacological intervention in dementia care. However, there are often questions as to the evidence behind why music works, the tangible benefits, and the best ways to implement music in this setting. Research confirms that music, especially active engagement in music, can greatly improve the quality of life of people living with Alzheimer’s disease and other forms of dementia. This workshop will explore multiple approaches to using music with people with dementia, including music listening, music recreation, and music therapy. Each method will be explained and the benefits will be …

Case Report: Optimizing Daily Function For People With Below-Elbow Limb Deficiency With The Softhand Pro, Amanda Theuer, Sasha Blue Godfrey, Kristin Zhao, Ryan Breighner, Manuel Catalano, Marco Santello, Antonio Bicchi, Karen L. Andrews

The Open Journal of Occupational Therapy

Background: Innovation in prosthetic devices for adults with upper limb loss is necessary to meet the demand for effective devices to optimize participation in daily activity. We evaluate the SoftHand Pro (SHP) as a terminal device to determine the application of this biologically-inspired prosthetic hand for use for a person with transradial limb deficiency.

Method: This case study describes and measures the first use of the SHP by an individual with transradial limb deficiency in their home environment. This paper reports the features and functionality of the SHP prototype and provides recommendations for changes to further optimize function. …

Conquer And Prevail Issue 36 Oct 15 2020, Wofford College. Office Of Marketing And Communications

Conquer and Prevail Newsletter

No abstract provided.

The Role Of Public Health Laws In Combating Plastic Pollution In Nigeria: Lessons From Other Selected Jurisdictions, Olaide Abass Gbadamosi

California Western International Law Journal

No abstract provided.

Trophic Structure Of Apex Fish Communities In Closed Versus Leaky Lakes Of Arctic Alaska, Stephen L. Klobucar, Phaedra Budy

Watershed Sciences Faculty Publications

Despite low species diversity and primary production, trophic structure (e.g., top predator species, predator size) is surprisingly variable among Arctic lakes. We investigated trophic structure in lakes of arctic Alaska containing arctic char Salvelinus alpinus using stomach contents and stable isotope ratios in two geographically-close but hydrologically-distinct lake clusters to investigate how these fish may interact and compete for limited food resources. Aside from different lake connectivity patterns (‘leaky’ versus ‘closed’), differing fish communities (up to five versus only two species) between lake clusters allowed us to test trophic hypotheses including: (1) arctic char are more piscivorous, and thereby grow …

From Beowulf Through Virginia Woolf To The Coastal Wolves Of British Columbia: Animals, Interdisciplinarity And The Environmental Humanities, Pamela Banting

The Goose

Researching and teaching literary works about wild animals within the university system can present productive challenges both within and across disciplinary structures and conventions.

Identifying Dietary Patterns In Irish Schoolchildren And Their Association With Nutritional Knowledge And Markers Of Health Before And After Intervention, Alison Merrotsy, Aoife L. Mccarthy, Seán Lacey, Tara Coppinger

Publications

The aim of the study was to identify dietary patterns (DP) and examine differences in anthropometric measures, blood pressure (BP), cardiorespiratory fitness and nutritional knowledge of 6- and 10-year-old children at baseline and following a nutrition and physical activity intervention, with respect to DP and treatment group. This is a longitudinal study. Food diary, nutritional knowledge questionnaire and 550-m walk/run test measured dietary intake, nutritional knowledge and cardiorespiratory fitness, respectively. BP, weight, height and waist circumference were also measured and BMI and waist-to-height ratio (WHtR) were derived. All measurements were performed at baseline and following intervention. Two primary schools (one …

Field Evaluation Of Recombinant Antigen Elisa In Detecting Zoonotic Schistosome Infection Among Water Buffaloes In Endemic Municipalities In The Philippines, Jose Ma. M. Angeles, Yasuyuki Goto, Masahi Kirinoki, Elena A. Villacorte, Kharleezelle J. Moendeg, Pilarita T. Rivera, Yuichi Chigusa, Shin-Ichiro Kawazu

Biology Faculty Publications

In this study, we investigated the use of recombinant antigens thioredoxin peroxidase-1 (rSjTPx-1) and tandem repeat rSj1TR in evaluating the antibody positivity rates of Schistosoma japonicum infection among water buffaloes from four endemic areas in the Philippines, two municipalities with high endemicity (Calatrava, Negros Occidental and Catarman, Northern Samar) and two municipalities nearing elimination with no cases of human schistosomiasis (Talibon and Trinidad, Bohol). These recombinant antigen ELISA assays were compared with other diagnostic tests including SEA-ELISA, FECT, and fecal-based PCR. Results showed that rSj1TR-ELISA has the highest agreement with PCR in all study areas. Furthermore, significant positivity rates among …

2020-2021 Common Data Set - Wright State University Lake Campus, Office Of Institutional Research & Effectiveness, Wright State University, Princeton Review

Common Data Set

The 2020-2021 Common Data Set of Wright State University Lake Campus from the Princeton Review. It includes data on admissions, student enrollment, faculty, class size, financial aid and other measures, using standard definitions that aid comparisons between schools.

Health And Disease Markers Correlate With Gut Microbiome Composition Across Thousands Of People., Ohad Manor, Chengzhen L Dai, Sergey A Kornilov, Brett Smith, Nathan D Price, Jennifer C Lovejoy, Sean M Gibbons, Andrew T Magis

Articles, Abstracts, and Reports

Variation in the human gut microbiome can reflect host lifestyle and behaviors and influence disease biomarker levels in the blood. Understanding the relationships between gut microbes and host phenotypes are critical for understanding wellness and disease. Here, we examine associations between the gut microbiota and ~150 host phenotypic features across ~3,400 individuals. We identify major axes of taxonomic variance in the gut and a putative diversity maximum along the Firmicutes-to-Bacteroidetes axis. Our analyses reveal both known and unknown associations between microbiome composition and host clinical markers and lifestyle factors, including host-microbe associations that are composition-specific. These results suggest potential opportunities …

Mutational Analysis Confirms The Presence Of Distal Inhibitor-Selectivity Determining Residues In B. Stearothermophilus Dihydrofolate Reductase, Tyler Eck, Seema Patel, Thomas Candela, Katherine Leon H, Michael Little, Natalia E. Reis, Uththara Liyanagunawardana, Ueli Gubler, Cheryl A. Janson, Jaclyn Catalano, Nina M. Goodey

Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works

Many antibacterial and antiparasitic drugs work by competitively inhibiting dihydrofolate reductase (DHFR), a vital enzyme in folate metabolism. The interactions between inhibitors and DHFR active site residues are known in many homologs but the contributions from distal residues are less understood. Identifying distal residues that aid in inhibitor binding can improve targeted drug development programs by accounting for distant influences that may be less conserved and subject to frequent resistance causing mutations. Previously, a novel, homology-based, computational approach that mines ligand inhibition data was used to predict residues involved in inhibitor selectivity in the DHFR family. Expectedly, some inhibitor selectivity …

2020-2021 Common Data Set - Wright State University Dayton Campus, Office Of Institutional Research & Effectiveness, Wright State University, Princeton Review

Common Data Set

The 2020-2021 Common Data Set of Wright State University Dayton Campus from the Princeton Review. It includes data on admissions, student enrollment, faculty, class size, financial aid and other measures, using standard definitions that aid comparisons between schools.

Distribution Of Aromatase In The Brain Of The African Cichlid Fish Astatotilapia Burtoni: Aromatase Expression, But Not Estrogen Receptors, Varies With Female Reproductive-State, Karen P. Maruska, Julie M. Butler, Chase Anselmo, Ganga Tandukar

Faculty Publications

© 2020 Wiley Periodicals, Inc. Estrogen synthesis and signaling in the brains of vertebrates has pleotropic effects ranging from neurogenesis to modulation of behaviors. The majority of studies on brain-derived estrogens focus on males, but estrogenic signaling in females likely plays important roles in regulation of reproductive cycling and social behaviors. We used females of the mouth brooding African cichlid fish, Astatotilapia burtoni, to test for reproductive state-dependent changes in estrogenic signaling capacity within microdissected brain nuclei that are important for social behaviors. Expression levels of the rate-limiting enzyme aromatase, but not estrogen receptors, measured by qPCR changes across the …