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2020

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Neural Activation Patterns Associated With Maternal Mouthbrooding And Energetic State In An African Cichlid Fish, Karen P. Maruska, Julie M. Butler, Karen E. Field, Christopher Forester, Ashley Augustus Oct 2020

Neural Activation Patterns Associated With Maternal Mouthbrooding And Energetic State In An African Cichlid Fish, Karen P. Maruska, Julie M. Butler, Karen E. Field, Christopher Forester, Ashley Augustus

Faculty Publications

© 2020 IBRO Parental care is widespread in the animal kingdom, but for many species, provisioning energetic resources must be balanced with trade-offs between self-promoting and offspring-promoting behaviors. However, little is known about the neural mechanisms underlying these motivational decisions. Mouthbrooding is an extreme form of parental care most common in fishes that provides an ideal opportunity to examine which brain regions are involved in parenting and energetics. The African cichlid fish Astatotilapia burtoni is a maternal mouthbrooder in which females hold developing young inside their mouths for 2 weeks. This brood care makes feeding impossible, so females undergo obligatory …


Framework For A Community Health Observing System For The Gulf Of Mexico Region: Preparing For Future Disasters, Paul Sandifer, Landon Knapp, Maureen Lichtveld, Ruth Manley, David Abramson, Rex Caffey, David Cochran, Tracy Collier, Kristie Ebi, Lawrence Engel, John Farrington, Melissa Finucane, Christine Hale, David Halpern, Emily Harville, Leslie Hart, Yulin Hswen, Barbara Kirkpatrick, Bruce Mcewen, Glenn Morris, Raymond Orbach, Lawrence Palinkas, Melissa Partyka, Dwayne Porter, Aric A. Prather, Teresa Rowles, Geoffrey Scott, Teresa Seeman, Helena Solo-Gabriele, Erik Svendsen, Terry Tincher, Juli Trtanj, Ann Hayward Walker Oct 2020

Framework For A Community Health Observing System For The Gulf Of Mexico Region: Preparing For Future Disasters, Paul Sandifer, Landon Knapp, Maureen Lichtveld, Ruth Manley, David Abramson, Rex Caffey, David Cochran, Tracy Collier, Kristie Ebi, Lawrence Engel, John Farrington, Melissa Finucane, Christine Hale, David Halpern, Emily Harville, Leslie Hart, Yulin Hswen, Barbara Kirkpatrick, Bruce Mcewen, Glenn Morris, Raymond Orbach, Lawrence Palinkas, Melissa Partyka, Dwayne Porter, Aric A. Prather, Teresa Rowles, Geoffrey Scott, Teresa Seeman, Helena Solo-Gabriele, Erik Svendsen, Terry Tincher, Juli Trtanj, Ann Hayward Walker

Faculty Publications

© Copyright © 2020 Sandifer, Knapp, Lichtveld, Manley, Abramson, Caffey, Cochran, Collier, Ebi, Engel, Farrington, Finucane, Hale, Halpern, Harville, Hart, Hswen, Kirkpatrick, McEwen, Morris, Orbach, Palinkas, Partyka, Porter, Prather, Rowles, Scott, Seeman, Solo-Gabriele, Svendsen, Tincher, Trtanj, Walker, Yehuda, Yip, Yoskowitz and Singer. The Gulf of Mexico (GoM) region is prone to disasters, including recurrent oil spills, hurricanes, floods, industrial accidents, harmful algal blooms, and the current COVID-19 pandemic. The GoM and other regions of the U.S. lack sufficient baseline health information to identify, attribute, mitigate, and facilitate prevention of major health effects of disasters. Developing capacity to assess adverse human …


Identification Of A Novel Endornavirus In Geranium Carolinianum And Occurrence Within Three Agroecosystems, Rachel Herschlag, Ryo Okada, Ricardo Iván Alcalá-Briseño, Eliezer Rodrigues De Souto, Rodrigo A. Valverde Oct 2020

Identification Of A Novel Endornavirus In Geranium Carolinianum And Occurrence Within Three Agroecosystems, Rachel Herschlag, Ryo Okada, Ricardo Iván Alcalá-Briseño, Eliezer Rodrigues De Souto, Rodrigo A. Valverde

Faculty Publications

A putative endornavirus was detected in Carolina geranium (Geranium carolinianum) in Louisiana, USA. The virus was provisionally named Geranium carolinianum endornavirus 1 (GcEV1). The viral RNA was sequenced, and it consisted of 14,625 nt containing a single ORF coding a putative polyprotein of 4815 aa with conserved domains for a helicase 1, peptidase C97, glycosyl transferase GTB-type, and RNA-dependent RNA polymerase 2. The 5′end consisted of 130 nt while the 3′end consisted of 54 nt ending in nine cytosine residues. The closest relative to GcEV1 was Phaseolus vulgaris endornavirus 3. In phylogenetic analyses, GcEV1 clustered with members of the genus …


Rethinking The Environmental Quality Of Brazilian Beaches: The Incidence Of Microplastics As Indicator For Sea Water And Sand Quality, Beatriz Nunes Diógenes, Marcelo De Oliveira Soares, Tarin Cristino Frota Mont’Alverne Oct 2020

Rethinking The Environmental Quality Of Brazilian Beaches: The Incidence Of Microplastics As Indicator For Sea Water And Sand Quality, Beatriz Nunes Diógenes, Marcelo De Oliveira Soares, Tarin Cristino Frota Mont’Alverne

California Western International Law Journal

No abstract provided.


A Review Of Integrative Imputation For Multi-Omics Datasets, Meng Song, Jonathan Greenbaum, Joseph Luttrell, Weihua Zhou, Chong Wu, Hui Shen, Ping Gong, Chaoyang Zhang, Hong Wen Deng Oct 2020

A Review Of Integrative Imputation For Multi-Omics Datasets, Meng Song, Jonathan Greenbaum, Joseph Luttrell, Weihua Zhou, Chong Wu, Hui Shen, Ping Gong, Chaoyang Zhang, Hong Wen Deng

Michigan Tech Publications, Part 1

Multi-omics studies, which explore the interactions between multiple types of biological factors, have significant advantages over single-omics analysis for their ability to provide a more holistic view of biological processes, uncover the causal and functional mechanisms for complex diseases, and facilitate new discoveries in precision medicine. However, omics datasets often contain missing values, and in multi-omics study designs it is common for individuals to be represented for some omics layers but not all. Since most statistical analyses cannot be applied directly to the incomplete datasets, imputation is typically performed to infer the missing values. Integrative imputation techniques which make use …


A Review Of Integrative Imputation For Multi-Omics Datasets, Meng Song, Jonathan Greenbaum, Joseph Luttrell, Weihua Zhou, Chong Wu, Hui Shen, Ping Gong, Chaoyang Zhang, Hong Wen Deng Oct 2020

A Review Of Integrative Imputation For Multi-Omics Datasets, Meng Song, Jonathan Greenbaum, Joseph Luttrell, Weihua Zhou, Chong Wu, Hui Shen, Ping Gong, Chaoyang Zhang, Hong Wen Deng

Faculty Publications

Multi-omics studies, which explore the interactions between multiple types of biological factors, have significant advantages over single-omics analysis for their ability to provide a more holistic view of biological processes, uncover the causal and functional mechanisms for complex diseases, and facilitate new discoveries in precision medicine. However, omics datasets often contain missing values, and in multi-omics study designs it is common for individuals to be represented for some omics layers but not all. Since most statistical analyses cannot be applied directly to the incomplete datasets, imputation is typically performed to infer the missing values. Integrative imputation techniques which make use …


Pinning The Conformation Of A Protein (Cora) In A Solute Matrix With Selective Binding, Warin Rangubpit, Sunan Kitjaruwankul, Pornthep Sompornpisut, R. B. Pandey Oct 2020

Pinning The Conformation Of A Protein (Cora) In A Solute Matrix With Selective Binding, Warin Rangubpit, Sunan Kitjaruwankul, Pornthep Sompornpisut, R. B. Pandey

Faculty Publications

Conformation of a protein (CorA) is examined in a matrix with mobile solute constituents as a function of solute–residue interaction strength (f) by a coarse-grained model with a Monte Carlo simulation. Solute particles are found to reach their targeted residue due to their unique interactions with the residues. Degree of slowing down of the protein depends on the interaction strength f. Unlike a predictable dependence of the radius of gyration of the same protein on interaction in an effective medium, it does not show a systematic dependence on interaction due to pinning caused by the solute binding. …


Faculty Senate Agenda Oct 2020

Faculty Senate Agenda

Faculty Senate Agendas

No abstract provided.


Freshwater Sediment Microbial Communities Are Not Resilient To Disturbance From Agricultural Land Runoff, Rachelle E. Beattie, Aditya Bandla, Sanjay Swarup, Krassimira R. Hristova Oct 2020

Freshwater Sediment Microbial Communities Are Not Resilient To Disturbance From Agricultural Land Runoff, Rachelle E. Beattie, Aditya Bandla, Sanjay Swarup, Krassimira R. Hristova

Biological Sciences Faculty Research and Publications

Microorganisms are critically important for the function of surface water ecosystems but are frequently subjected to anthropogenic disturbances at either acute (pulse) or long-term (press) scales. Response and recovery of microbial community composition and function following pulse disturbance is well-studied in controlled, laboratory scale experiments but is less well-understood in natural environments undergoing continual press disturbance. The objectives of this study were to determine the drivers of sediment microbial compositional and functional changes in freshwaters receiving continual press disturbance from agricultural land runoff and to evaluate the ability of the native microbial community to resist disturbance related changes as a …


High-Temperature Resistant Water-Soluble Polymers Derived From Exotic Amino Acids, Sumant Dwivedi, Aniruddha Nag, Shigeki Sakamoto, Yasuyoshi Funahashi, Toyohiro Harimoto, Kenji Takada, Tatsuo Kaneko Oct 2020

High-Temperature Resistant Water-Soluble Polymers Derived From Exotic Amino Acids, Sumant Dwivedi, Aniruddha Nag, Shigeki Sakamoto, Yasuyoshi Funahashi, Toyohiro Harimoto, Kenji Takada, Tatsuo Kaneko

Faculty Publications

© The Royal Society of Chemistry. High-performance water-soluble polymers have a wide range of applications from engineering materials to biomedical plastics. However, existing materials are either natural polymers that lack high thermostability or rigid synthetic polymers. Therefore, we design an amino acid-derived building block, 4,4′-diamino-α-truxillate dianion (4ATA2−), that induces water solubility in high-performance polymers. Polyimides containing 4ATA2− units are intrinsically water-soluble and are processed into films cast from an aqueous solution. The resulting polyimide films exhibit exceptional transparency and extremely high thermal stability. In addition, the films can be made insoluble in water by simple post-treatment using …


Bioinformatic Analysis Of Venom Proteins From Dasymutilla Occidentalis, Eva Gunawan Oct 2020

Bioinformatic Analysis Of Venom Proteins From Dasymutilla Occidentalis, Eva Gunawan

Theses and Dissertations

Venom proteins have been found in a wide range of species in the animal kingdom. These venoms serve various functions such as defense against predators, hunting for food, and parasitism for reproduction. Because of their diverse functions, venom proteins are utilized in agrochemical treatments for protection from pests as well as treatments to control human diseases. Venoms, including those coming from a range of insect species, have been manipulated for these purposes, but many remain uncharacterized. Currently, one of the orders that venom-based research is focusing on are parasitoids from the order Hymenoptera. The purpose of some venom proteins in …


Impact Of Uv-Induced Ozone And Low-Energy Ar+-Ion Cleaning On The Chemical Structure Of Cu(In,Ga)(S,Se)2 Absorber Surfaces, Victor R. Van Maris, Dirk Hauschild, Thomas P. Niesen, Patrick Eraerds, Thomas Dalibor, Jörg Palm, Monika Blum, Wanli Yang, Clemens Heske, Lothar Weinhardt Oct 2020

Impact Of Uv-Induced Ozone And Low-Energy Ar+-Ion Cleaning On The Chemical Structure Of Cu(In,Ga)(S,Se)2 Absorber Surfaces, Victor R. Van Maris, Dirk Hauschild, Thomas P. Niesen, Patrick Eraerds, Thomas Dalibor, Jörg Palm, Monika Blum, Wanli Yang, Clemens Heske, Lothar Weinhardt

Chemistry and Biochemistry Faculty Research

Dry buffer layer deposition techniques for chalcopyrite (CIGSSe)-based thin-film solar cells lack the surface-cleaning characteristics of the commonly used CdS or Zn(O,S) wet-chemical bath deposition. A UV-induced ozone and/or a low-energy Ar+-ion treatment could provide dry CIGSSe surface cleaning steps. To study the impact of these treatments, the chemical surface structure of a CIGSSe absorber is investigated. For this purpose, a set of surface-sensitive spectroscopic methods, i.e., laboratory-based x-ray photoelectron spectroscopy and x-ray-excited Auger electron spectroscopy, is combined with synchrotron-based soft x-ray emission spectroscopy. After treatment times as short as 15 s, the UV-induced ozone treatment decreases the amount of …


Language Matters: Examining The Language-Related Needs And Wants Of Writers In A First-Year University Writing Course, Grant Eckstein, Dana Ferris Oct 2020

Language Matters: Examining The Language-Related Needs And Wants Of Writers In A First-Year University Writing Course, Grant Eckstein, Dana Ferris

Faculty Publications

All writing involves complex linguistic knowledge and thoughtful decision-making. But where do students acquire the linguistic tools needed to write effectively? Many students come from diverse backgrounds and may need additional support and/or instruction in language and grammar. In order to better understand this situation, we conducted a qualitative multiple-case study to examine the experiences of 12 students in a first-year university-level composition course to understand the extent of their diverse learning backgrounds and language needs and expectations. We synthesized information from surveys, interviews, and written texts into narratives about each student’s attitudes toward language and writing and also examined …


Andrews University Enrollment And Rankings Report For Fall 2020 On The Berrien Springs Campus, Stephen Payne Oct 2020

Andrews University Enrollment And Rankings Report For Fall 2020 On The Berrien Springs Campus, Stephen Payne

Andrews Agenda: Campus News

No abstract provided.


Internationally Lauded Scientist Named Distinguished Alumnus, Whitney Tarpy Oct 2020

Internationally Lauded Scientist Named Distinguished Alumnus, Whitney Tarpy

University of Mississippi News

Hassan Y. Aboul-Enein to deliver Joseph Sam Distinguished Alumnus Lecture on Monday via Zoom


Gait Complexity Is Acutely Restored In Older Adults When Walking To A Fractal-Like Visual Stimulus, Joao R. Vaz, Brian Knarr, Nicholas Stergiou Oct 2020

Gait Complexity Is Acutely Restored In Older Adults When Walking To A Fractal-Like Visual Stimulus, Joao R. Vaz, Brian Knarr, Nicholas Stergiou

Journal Articles

Typically, gait rehabilitation uses an invariant stimulus paradigm to improve gait related deficiencies. However, this approach may not be optimal as it does not incorporate gait complexity, or in more precise words, the variable fractal-like nature found in the gait fluctuations commonly observed in healthy populations. Aging which also affects gait complexity, resulting in a loss of adaptability to the surrounding environment, could benefit from gait rehabilitation that incorporates a variable fractal-like stimulus paradigm. Therefore, the present study aimed to investigate the effect of a variable fractal-like visual stimulus on the stride-to-stride fluctuations of older adults during overground walking. Additionally, …


Environmental Stewardship Promotes A Sense Of Place: Coral Health Monitoring On Maui, Cynthia Brunold-Conesa Oct 2020

Environmental Stewardship Promotes A Sense Of Place: Coral Health Monitoring On Maui, Cynthia Brunold-Conesa

The International Journal of Ecopsychology (IJE)

Environmental stewardship is an integral aspect of the Montessori curriculum. It usually includes care of the school’s setting (classrooms, grounds, gardens, eating areas, etc.) and, depending on each school’s unique situation, ideally extends into the larger environment in which the school is situated. During the 2014-15 school year, our class of Middle School students at Montessori Hale O Keiki (MHOK) were asked to select community service projects that were directly relevant to environmental and/or ecological issues on Maui. For our students, Coral Watch was the perfect project through which to integrate marine science, environmental stewardship, and community service. Through a …


Medieval Thinking In The 21st Century: Crystal Balls, Black Swans, And Darwin's Finches In The Time Of Corona, George Conesa Oct 2020

Medieval Thinking In The 21st Century: Crystal Balls, Black Swans, And Darwin's Finches In The Time Of Corona, George Conesa

The International Journal of Ecopsychology (IJE)

Twenty years into the 21st Century, a sizable swath of the world populace thinks, makes decisions, and defines itself in a conflicted and contradictory chimera. Millions of individuals make use of cutting-edge technologies while simultaneously throwing salt over their shoulders and consulting with the local ‘healer’ about any number of illnesses--to caricaturize, a sort of medieval-thinker-tech-savvy orientation. It is here affirmed that the practical consequences of this agentic amalgamation, modes of thinking, and “being in the world” are counterproductive at best and self-defeating at worst, resulting in much uncertainty and leading to, for example, mixed messages in public health …


Indigenous Animistic Belief Systems And Integrated Science: Perspective On Humans’ Relationship With Nature And The Coronavirus Pandemic, Cesario Garcia Oct 2020

Indigenous Animistic Belief Systems And Integrated Science: Perspective On Humans’ Relationship With Nature And The Coronavirus Pandemic, Cesario Garcia

The International Journal of Ecopsychology (IJE)

This paper explores some perspectives of indigenous animistic belief systems from researchers who have made observations while studying amongst North American tribes. Specifically, it will address indigenous interactions with the natural world and, in particular, their belief that humans are a part of nature. Next, other perspectives, not rooted in Indigenous belief systems, will be discussed that demonstrate how other cultures and individuals across the globe also view humans as a part of nature, including concepts found in Morita Therapy (Morita, 1928), Arne Naess’ (1987) theory of the ‘ecological self’, and nations around the world that are implementing policies that …


Book Review: Giuseppe T. Cirella’S (Ed.), Sustainable Human-Nature Relations: Environmental Scholarship, Economic Evaluation, Urban Strategies. (Springer Nature Singapore Pte Ltd., 2020), Editorial Board Oct 2020

Book Review: Giuseppe T. Cirella’S (Ed.), Sustainable Human-Nature Relations: Environmental Scholarship, Economic Evaluation, Urban Strategies. (Springer Nature Singapore Pte Ltd., 2020), Editorial Board

The International Journal of Ecopsychology (IJE)

No abstract provided.


“Healthy Country, Healthy People”: Aboriginal Embodied Knowledge Systems In Human/Nature Interrelationships, Liz Cameron Oct 2020

“Healthy Country, Healthy People”: Aboriginal Embodied Knowledge Systems In Human/Nature Interrelationships, Liz Cameron

The International Journal of Ecopsychology (IJE)

The relationships between humans and nature require interdisciplinary perspectives to develop expanded understandings at this crucial time for the planet and its inhabitants. A poignant step towards improving the global ecological situation--which includes human survival and flourishing--is to reconnect our human/nature relationships. From an Australian Aboriginal standpoint, human-nature connectedness is integrally embedded in the relationship to the natural world that is termed Country. This term not only illustrates geographical boundaries but encompasses the harmony and balance of all living things within a cultural and spiritual context. At the interface of this knowledge, ways of thinking, feeling and being …


Tom Bombadil And The Spirit Of Objectivity, Dani Inkpen Oct 2020

Tom Bombadil And The Spirit Of Objectivity, Dani Inkpen

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

No abstract provided.


Swimming Of Pelagic Snails: Kinematics And Fluid Dynamics, Ferhat Karakas Oct 2020

Swimming Of Pelagic Snails: Kinematics And Fluid Dynamics, Ferhat Karakas

USF Tampa Graduate Theses and Dissertations

Pteropods (also known as sea butterflies or sea angels), are holoplanktonic marine snails which swim by flapping a pair of extremely flexible wings. The wings are modified from the molluscan foot and the wing motions are supported by the fluid pressure without any rigid support. Sea angels (gymnosome pteropods) are completely naked; in contrast, sea butterflies (thecosome pteropods) have negatively buoyant aragonite shells which vary in geometry and size among different species. Pteropods are seasonally abundant in the ocean, and an important food source for the other zooplanktons, fishes, and whales. Though studies have been conducted regarding their biology, ecology, …


Spatiotemporal Analysis Of Cochlear Nucleus Innervation By Spiral Ganglion Neurons That Serve Distinct Regions Of The Cochlea, Jennifer L. Scheffel, Samiha S. Mohammed, Chloe K. Borcean, Annie J. Parng, Hyun Ju Yoon, Darwin A. Gutierrez, Wei-Ming Yu Oct 2020

Spatiotemporal Analysis Of Cochlear Nucleus Innervation By Spiral Ganglion Neurons That Serve Distinct Regions Of The Cochlea, Jennifer L. Scheffel, Samiha S. Mohammed, Chloe K. Borcean, Annie J. Parng, Hyun Ju Yoon, Darwin A. Gutierrez, Wei-Ming Yu

Biology: Faculty Publications and Other Works

Cochlear neurons innervate the brainstem cochlear nucleus in a tonotopic fashion according to their sensitivity to different sound frequencies (known as the neuron’s characteristic frequency). It is unclear whether these neurons with distinct characteristic frequencies use different strategies to innervate the cochlear nucleus. Here, we use genetic approaches to differentially label spiral ganglion neurons (SGNs) and their auditory nerve fibers (ANFs) that relay different characteristic frequencies in mice. We found that SGN populations that supply distinct regions of the cochlea employ different cellular strategies to target and innervate neurons in the cochlear nucleus during tonotopic map formation. ANFs that will …


The George-Anne Inkwell Edition, Georgia Southern University Oct 2020

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.


The George-Anne, Georgia Southern University Oct 2020

The George-Anne, Georgia Southern University

The George-Anne

  • ONE YEAR SINCE THE BOOK BURNING
  • Flu season among COVID-19
  • 14 positive cases during the eighth week
  • Quarantine hobbies
  • Soaring 20s: Homecoming 2020
  • Department of Art to showcase 5 students' art
  • Georgia Southern releases 27-page Inclusive Excellence action plan
  • The man behind the bird
  • Eagles add October 17 game against UMASS to schedule
  • Puzzles


A Critique Of Relationship Between Performance And Effort Expectancy Of Lecturer’S And Their Adoption Of Open Access Scholarly Publishing In Nigerian Universities., Blessing Otubelu, Chinwe Veronica Anunobi Dr. Oct 2020

A Critique Of Relationship Between Performance And Effort Expectancy Of Lecturer’S And Their Adoption Of Open Access Scholarly Publishing In Nigerian Universities., Blessing Otubelu, Chinwe Veronica Anunobi Dr.

Library Philosophy and Practice (e-journal)

The study investigated the relationships between lecturers’ performance expectancy, effort expectancy and their adoption of open access scholarly publishing in the state universities. A correlational research design was adopted for the study. The population of the study comprised 1,111 lecturers in Faculties of Education and Sciences in the five state universities in the South-East of Nigeria while the sample was 834 respondents selected through proportionate sampling technique. The alpha coefficients of the instrument were 0.85 and 0.83 for the two sections of the instrument. The Pearson Product Moment correlation was used to answer the research questions while t-test was used …


Triplet Therapeutics Aims To Transform The Approach To Treating Huntington's Disease, Similar Disorders, Kenneth P. Serbin Oct 2020

Triplet Therapeutics Aims To Transform The Approach To Treating Huntington's Disease, Similar Disorders, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.


October 15, 2020, James Madison University Oct 2020

October 15, 2020, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.


Tumor Somatic Mutations Also Existing As Germline Polymorphisms May Help To Identify Functional Snps From Genome-Wide Association Studies, Ivan P Gorlov, Xiangjun Xia, Spiridon Tsavachidis, Olga Y Gorlova, Christopher I Amos Oct 2020

Tumor Somatic Mutations Also Existing As Germline Polymorphisms May Help To Identify Functional Snps From Genome-Wide Association Studies, Ivan P Gorlov, Xiangjun Xia, Spiridon Tsavachidis, Olga Y Gorlova, Christopher I Amos

Faculty, Staff and Students Publications

We hypothesized that a joint analysis of cancer risk-associated single-nucleotide polymorphism (SNP) and somatic mutations in tumor samples can predict functional and potentially causal SNPs from GWASs. We used mutations reported in the Catalog of Somatic Mutations in Cancer (COSMIC). Confirmed somatic mutations were subdivided into two groups: (1) mutations reported as SNPs, which we call mutational/SNPs and (2) somatic mutations that are not reported as SNPs, which we call mutational/noSNPs. It is generally accepted that the number of times a somatic mutation is reported in COSMIC correlates with its selective advantage to tumors, with more frequently reported mutations being …