Digital Commons Network^™

Burst Mitofusin Activation Reverses Neuromuscular Dysfunction In Murine Cmt2a, Antonietta Franco, Xiawei Dang, Emily K. Walton, Joshua N. Ho, Barbara Zablocka, Cindy Ly, Timothy M. Miller, Robert H. Baloh, Michael E. Shy, Andrew S. Yoo, Gerald W. Dorn

Open Access Publications

Charcot-Marie-Tooth disease type 2A (CMT2A) is an untreatable childhood peripheral neuropathy caused by mutations of the mitochondrial fusion protein, mitofusin (MFN) 2. Here, pharmacological activation of endogenous normal mitofusins overcame dominant inhibitory effects of CMT2A mutants in reprogrammed human patient motor neurons, reversing hallmark mitochondrial stasis and fragmentation independent of causal

Evidence Of Tent Use By The Pygmy Fruit-Eating Bat Dermanura Phaeotis (Chiroptera: Phyllostomidae) In Nayarit, México, Celia López-González

Western North American Naturalist

Little information on the making or use of tents by bats is available for Mexico, although tent-making phyllostomids are common and abundant throughout the Mexican tropics. I report the use of tents by Dermanura phaeotis in northern Nayarit, México, in the northern portion of the species’ distribution. One bat was found roosting in a boat-apical tent located in a banana (Musa paradisiaca) grove surrounded by tropical semideciduous forest. Other fronds in the same grove were similarly modified as tents.


Poco se sabe sobre los murciélagos que usan o hacen tiendas en México, a pesar de que los filostómidos …

The Impacts Of Membrane Modulators On Membrane Material Properties At Microscopic And Nanoscopic Levels, Chinta Mani Aryal

USF Tampa Graduate Theses and Dissertations

Peptide-membrane interactions depict the cell’s response to an external molecule. This is a critical event to evaluate the peptide’s function and effect as well as the response of target molecule. The understanding of the mechanism of action of peptide in a molecular level is important, for example, this may be useful in developing the therapeutic strategy. Peptides are the functional macromolecules which are actively researched among bio-related fields. Model membrane systems that mimic the real cell have been useful platform to test the perturbation upon peptide addition. In this thesis, we investigate the membrane modulation behavior of three peptides (modulators) …

The Fgf8 Subfamily (Fgf8, Fgf17 And Fgf18) Is Required For Closure Of The Embryonic Ventral Body Wall, Michael Boylan, Matthew J Anderson, David M Ornitz, Mark Lewandoski

Open Access Publications

The closure of the embryonic ventral body wall in amniotes is an important morphogenetic event and is essential for life. Defects in human ventral wall closure are a major class of birth defect and a significant health burden. Despite this, very little is understood about how the ventral body wall is formed. Here, we show that fibroblast growth factor (FGF) ligands FGF8, FGF17 and FGF18 are essential for this process. Conditional mouse mutants for these genes display subtle migratory defects in the abdominal muscles of the ventral body wall and an enlarged umbilical ring, through which the internal organs are …

Mendeley Readership Count: An Investigation Of Sambalpur University Publications From 1971-2018, Lambodara Parabhoi, Trinayan Borgohain, Ramani Ranjan Sahu

Library Philosophy and Practice (e-journal)

Mendeley offers readership statistic to publications and use these readership statistics to evaluate research performance of an individual. The primary purpose of this paper is to investigate the Mendeley readership counts of Sambalpur University's publications from 1971 to 2018. In this study; bibliographical data exported from Scopus using affiliations search tab and exported data between1971 to 2018. A total of 1553 records were found. The exported data converted into a text file and run in Webometric Analyst software and exported the Mendeley readership data from Mendeley website. A total 1399 record existed in the Mendeley database, in which 173 data …

Macrophage-Associated Lipin-1 Promotes Β-Oxidation In Response To Proresolving Stimuli, Robert M Schilke, Cassidy M R Blackburn, Shashanka Rao, David M Krzywanski, Brian N Finck, Matthew D Woolard

2020-Current year OA Pubs

Macrophages reprogram their metabolism to promote appropriate responses. Proresolving macrophages primarily use fatty acid oxidation as an energy source. Metabolites generated during the catabolism of fatty acids aid in the resolution of inflammation and tissue repair, but the regulatory mechanisms that control lipid metabolism in macrophages are not fully elucidated. Lipin-1, a phosphatidic acid phosphatase that has transcriptional coregulator activity, regulates lipid metabolism in a variety of cells. In this current study, we show that lipin-1 is required for increased oxidative phosphorylation in IL-4 stimulated mouse (

Serious Neonatal Morbidities Are Associated With Differences In Dna Methylation Among Very Preterm Infants., Todd M. Everson, T Michael O'Shea, Amber Burt, Karen Hermetz, Brian S. Carter, Jennifer Helderman, Julie A. Hofheimer, Elisabeth C. Mcgowan, Charles R. Neal, Steven L. Pastyrnak, Lynne M. Smith, Antoine Soliman, Sheri A. Dellagrotta, Lynne M. Dansereau, James F. Padbury, Barry M. Lester, Carmen J. Marsit

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Infants born very preterm are more likely to experience neonatal morbidities compared to their term peers. Variations in DNA methylation (DNAm) associated with these morbidities may yield novel information about the processes impacted by these morbidities.

METHODS: This study included 532 infants born < 30 weeks gestation, participating in the Neonatal Neurobehavior and Outcomes in Very Preterm Infants study. We used a neonatal morbidity risk score, which was an additive index of the number of morbidities experienced during the NICU stay, including bronchopulmonary dysplasia (BPD), severe brain injury, serious neonatal infections, and severe retinopathy of prematurity. DNA was collected from buccal cells at discharge from the NICU, and DNAm was measured using the Illumina MethylationEPIC. We tested for differential methylation in association with the neonatal morbidity risk score then tested for differentially methylated regions (DMRs) and overrepresentation of biological pathways.

RESULTS: We identified ten differentially methylated CpGs (α Bonferroni-adjusted for 706,278 tests) that were associated with increasing neonatal morbidity risk scores at three intergenic regions and at HPS4, SRRD, FGFR1OP, TNS3, TMEM266, LRRC3B, ZNF780A, and TENM2. These mostly followed dose-response patterns, for 8 CpGs increasing DNAm associated with increased numbers of morbidities, while for 2 CpGs …

The Degeneration Evaluation Of Xilamuren Grassland, Zhongju Meng, Yong Gao, Lanhua Li

IGC Proceedings (1977-2023)

No abstract provided.

Preliminary Study On Classified Index System Of Grazing Subalpine Meadow In Northwest Sichuan, Youmin Gan, Ying Qiu, Yuanjia Luo, Qin Wang, Ling Fei, Yanchun Wang

IGC Proceedings (1977-2023)

No abstract provided.

Effect Of Three Classroom Research Experiences On Science Attitudes, Lauren K. Lucas, Frances K. Hunter, Zachariah Gompert

Journal on Empowering Teaching Excellence

Here we evaluate undergraduate student attitudes about science after each of three authentic research experiences in a semester of an introductory biology laboratory course at Utah State University. The three course-based research experiences (CUREs) vary in length and student freedom, and they cover different areas of biology. Students responded to the science attitude items of the CURE Survey. When compared to national data, our students faired similarly, and all students struggled with certain epistemic assumptions about science knowledge. As also seen in the national database, change in science attitude was slight and nonlinear. Student self confidence in what a career …

Fa 2020 About This Issue: The Power In Slowing Down

Journal on Empowering Teaching Excellence

Whether it be videotaping, guided classroom conversations, lecture-based, or written, feedback is the backbone of educational excellence. We use it to mentor beginning undergraduates, writers, readers, explorers, and experimenters. And, if we are thoughtful, feedback becomes a loop by which we slow down learning, we engage reading, writing and exploring, and we collaborate our way to becoming better.

Full Issue: Journal On Empowering Teaching Excellence, Volume 4, Issue 2

Journal on Empowering Teaching Excellence

The full Fall 2020 issue (Volume 4, Issue 2) of the Journal on Empowering Teaching Excellence.

Urban Agriculture In Asia To Meet The Food Production Challenges Of Urbanization: A Review, Onyekachukwu Akaeze, Dilip Nandwani

Agricultural and Environmental Sciences Faculty Research

Urban expansion in Asia is concentrated in metropolitan areas. This has adversely affected in-city food production by decreasing farmlands in and around urban centers. Asian countries have experienced fast disappearance of urban-fringe farmland which at some point provided 70% of the vegetables consumed by the city's population. Uneven distribution of incomes, along with an increase in urban poverty, has further exacerbated the already critical problems of low quantity and quality and high prices of wholesome food. In India, it is estimated that five out of every six urban families typically spend 70% of their income on food. The United Nations …

Sga 52 Senate 2020-10-18 Minutes, Niu Student Government Association Senate

Student Government Association Archives

No abstract provided.

Efficacy Of Platelet Rich Plasma Injections Vs. Topical Minoxidil In Androgenic Alopecia, Scott Sproul

Physician Assistant Studies | Student Authored Articles

No abstract provided.

Fine-Tuning Of Alanyl-Trna Synthetase Quality Control Alleviates Global Dysregulation Of The Proteome, Paul Kelly, Arundhati Kavoor, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

One integral step in the transition from a nucleic acid encoded-genome to functional proteins is the aminoacylation of tRNA molecules. To perform this activity, aminoacyl-tRNA synthetases (aaRSs) activate free amino acids in the cell forming an aminoacyl-adenylate before transferring the amino acid on to its cognate tRNA. These newly formed aminoacyl-tRNA (aa-tRNA) can then be used by the ribosome during mRNA decoding. In Escherichia coli, there are twenty aaRSs encoded in the genome, each of which corresponds to one of the twenty proteinogenic amino acids used in translation. Given the shared chemicophysical properties of many amino acids, aaRSs have …

Artificial Nightlight Alters The Predator–Prey Dynamics Of An Apex Carnivore, Mark A. Ditmer, David C. Stoner, Clinton D. Francis, Jesse R. Barber, James D. Forster, David M. Choate, Kirsten E. Ironside, Kathleen M. Longshore, Kent R. Hersey, Randy T. Larsen, Brock R. Mcmillan, Daniel D. Olson, Alyson M. Andreasen, Jon P. Beckmann, P. Brandon Holton, Terry A. Messmer, Neil H. Carter

Life Sciences Faculty Research

Artificial nightlight is increasingly recognized as an important environmental disturbance that influences the habitats and fitness of numerous species. However, its effects on wide‐ranging vertebrates and their interactions remain unclear. Light pollution has the potential to amplify land‐use change, and as such, answering the question of how this sensory stimulant affects behavior and habitat use of species valued for their ecological roles and economic impacts is critical for conservation and land‐use planning. Here, we combined satellite‐derived estimates of light pollution, with GPS‐data from cougars Puma concolor (n = 56), mule deer Odocoileus hemionus (n = 263) and locations of cougar‐killed …

Study On Soil Properties Of Degraded Desert Plain Grassland In North Tianshan Of Xinjiang, Yanmin Fan, Jinzhong Zhu, Caihong Wang

IGC Proceedings (1977-2023)

No abstract provided.

Ecological Indicators In A Derived Savanna Disturbed By Oil Spillage And Vegetation Fire In Nigeria, Emmanuel Nzegbule

IGC Proceedings (1977-2023)

No abstract provided.

Bush Encroachment: A Major Threat To Pastoralists Livelihood In Ethiopia, Ebro Abule

IGC Proceedings (1977-2023)

No abstract provided.

Strategy And Issues Of Ecological Grass Construction In Jilin Province, F. G. Du, W. W. Lu

IGC Proceedings (1977-2023)

No abstract provided.

Self Rehabilitation Of Degraded Mongolian Rangeland By Grazing Exclosure, A. Darhiihuu, O. Lkhagvajav, A. Mels, B. Baatar, B. Densambuu, L. Namdag, T. Sainkhuu, Andreas Lüscher, J. Nösberger

IGC Proceedings (1977-2023)

No abstract provided.

Rethinking Overgrazing And Strategies For Its Management In Inner Mongolia, Dalintai Churiya

IGC Proceedings (1977-2023)

No abstract provided.

Establishing A Dynamic Us Federal National Vegetation Classification Process Standard In Partnership With Non Federal Partners, Ralph H. Crawford

IGC Proceedings (1977-2023)

No abstract provided.

Grassland Deterioration In The Source Region Of Yangtze‐Yellow Rivers In China And Integrated Control Of Ecological Environment, Quangong Chen, Yulin Mao

IGC Proceedings (1977-2023)

No abstract provided.

Plant Functional Groups Composition Associated To Management Practices In Temperate Natural Grasslands (Flooding Pampa, Argentina), Mónica G. Agnusdei, O. Fernández, M. R. Colabelli, P. Vázquez, O. Vignolio, R. C. Fernández Grecco

IGC Proceedings (1977-2023)

No abstract provided.

Global Burden Of 87 Risk Factors In 204 Countries And Territories, 1990–2019: A Systematic Analysis For The Global Burden Of Disease Study 2019, Christopher J L Murray, Veincent Christian F. Pepito, Gbd 2019 Risk Factors Collaborators, 938 Co-Authors

Ateneo School of Medicine and Public Health Publications

Background

Rigorous analysis of levels and trends in exposure to leading risk factors and quantification of their effect on human health are important to identify where public health is making progress and in which cases current efforts are inadequate. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a standardised and comprehensive assessment of the magnitude of risk factor exposure, relative risk, and attributable burden of disease.

Methods

GBD 2019 estimated attributable mortality, years of life lost (YLLs), years of life lived with disability (YLDs), and disability-adjusted life-years (DALYs) for 87 risk factors and combinations of …

Global Age-Sex-Specific Fertility, Mortality, Healthy Life Expectancy (Hale), And Population Estimates In 204 Countries And Territories, 1950–2019: A Comprehensive Demographic Analysis For The Global Burden Of Disease Study 2019, Kaja M. Abbas, Haidong Wang, Veincent Christian F. Pepito, Gbd 2019 Demographics Collaborators, 725 Co-Authors

Ateneo School of Medicine and Public Health Publications

Background

Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019.

Methods

8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used …

Sport-Specific Differences In Dynamic Visual Acuity And Gaze Stabilization In Division-I Collegiate Athletes, Carolina Quintana, Nicholas R. Heebner, Anne D. Olson, J. P. Abt, Matthew C. Hoch

Sports Medicine Research Institute Faculty Publications

BACKGROUND: The vestibular-ocular reflex (VOR) integrates the vestibular and ocular systems to maintain gaze during head motion. This reflex is often negatively affected following sport-related concussion. Objective measures of gaze stability, a function mediated by the VOR, such as the computerized dynamic visual acuity test (DVAT) and gaze stabilization test (GST), may have utility in concussion management. However, normative data specific to sport, sex, or concussion history have not been established in collegiate athletes.

OBJECTIVE: The objective of this study was to establish normative values for the DVAT and GST in collegiate athletes and explore the effect of sport, sex, …

Ketchikan Cup O'News 2020-10, Michelle Lampton

Ketchikan Cup O' News

No abstract provided.