Digital Commons Network^™

River Restoration And Economic Development Through Grassland Management: A Case Study Of The James River, South Dakota, U.S.A., Jeremy P. Duehr, Richard G. Wiebe

IGC Proceedings (1977-2023)

No abstract provided.

Multistage Optimal Homotopy Asymptotic Method For The Nonlinear Riccati Ordinary Differential Equation In Nonlinear Physics, Niaz Ali Shah, Imtiaz Ahmad, Omar Bazighifan, Ahmed E. Abouelregal, Hijaz Ahmad

Applied Mathematics & Information Sciences

The present paper addresses the approximate analytical solution of the nonlinear Riccati differential equations using the Multistage homotopy asymptotic method which is used in nonlinear physics. The suggested algorithm is accurate, effective and simple to utilize semi-analytic tool for nonlinear problems. To test accuracy of the recommended algorithm serval test problems are considered and the obtained results are compared with those of the recent literature. These results revealed accuracy and efficiency of the suggested method.

Bioanalytical Assay Development And Validation For The Pharmacokinetic Study Of Gmc1, A Novel Fkbp52 Co-Chaperone Inhibitor For Castration Resistant Prostate Cancer, Oscar Ekpenyong, Candace Cooper, Jing Ma, Naihsuan C. Guy, Ashley N. Payan, Fuqiang Ban, Artem Cherkasov, Marc B. Cox, Dong Liang, Huan Xie

Faculty Publications

Background: GMC1 (2-(1H-benzimidazol-2-ylsulfanyl)-N-[(Z)-(4-methoxyphenyl) methylideneamino] acetamide) effectively inhibits androgen receptor function by binding directly to FKBP52. This is a novel mechanism for the treatment of castration resistant prostate cancer (CRPC). Methods: an LC-MS/MS method was developed and validated to quantify GMC1 in plasma and urine from pharmacokinetics studies in rats. An ultra-high-performance liquid chromatography (UHPLC) system equipped with a Waters XTerra MS C18 column was used for chromatographic separation by gradient elution with 0.1% (v/v) formic acid in water and methanol. A Sciex 4000 QTRAP® mass spectrometer was used for analysis by multiple reaction monitoring (MRM) in positive mode; the specific …

Deficiency Of Splicing Factor 1 (Sf1) Reduces Intestinal Polyp Incidence In ApcMin/+ Mice, Jyotsna D. Godavarthi, Shahrazad Polk, Lisa Nunez, Amruthesh Shivachar, Nancy L. Glenn Griesinger, Angabin Matin

Faculty Publications

Background: Splicing factor 1 (SF1) is a conserved alternative splicing factor expressed in many different mammalian cell types. The genetically modified Sf1+/− (or Sf1β-geo/+ ) mice express reduced levels of SF1 protein in mouse tissues, including in cells of the intestines. Mutational inactivation of human adenomatous polyposis coli (APC) gene deregulates the Wnt signaling pathway and is a frequent genetic event in colon cancers. Mice with a point mutation in the Apc gene (ApcMin/+ ) also develop numerous intestinal polyps at a young age. Our aim was to determine the effect of reduced SF1 levels on polyp development due to …

Histone Deacetylase Inhibitors As Multitarget-Directed Epi-Drugs In Blocking Pi3k Oncogenic Signaling: A Polypharmacology Approach, Kasturi Ranganna, Chelliah Selvam, Amruthesh Shivachar, Zivar Yousefipour

Faculty Publications

Genetic mutations and aberrant epigenetic alterations are the triggers for carcinogenesis. The emergence of the drugs targeting epigenetic aberrations has provided a better outlook for cancer treatment. Histone deacetylases (HDACs) are epigenetic modifiers playing critical roles in numerous key biological functions. Inappropriate expression of HDACs and dysregulation of PI3K signaling pathway are common aberrations observed in human diseases, particularly in cancers. Histone deacetylase inhibitors (HDACIs) are a class of epigenetic small-molecular therapeutics exhibiting promising applications in the treatment of hematological and solid malignancies, and in non-neoplastic diseases. Although HDACIs as single agents exhibit synergy by inhibiting HDAC and the PI3K …

Impact: The Visual Communication Of Information, Jennifer Shields, Mark Cabrinha, Sasha Menshikova, Catherine Trujillo, Emily Chung, Miles Young, Hope Golden, Laura Akatsu Kuffner, Markus Rogne, Aimie Olson

Creative Works

Impact: The Visual Communication of Information focuses on the diversity of visual communication created by students, faculty, and staff across California Polytechnic State University, San Luis Obispo. Drawing from a multitude of methods in courses and activities across the campus, the exhibit displays the influences of visual communication in fields ranging from statistical data and geography, to art, design, and engineering, to performance and physics. This project was made possible by a gift from the Austin and Gabriela Hearst Foundation.

This catalog represents the onsite exhibit of the same name, which opened in winter of 2020 at Robert E. Kennedy …

Gene Selection For Optimal Prediction Of Cell Position In Tissues From Single-Cell Transcriptomics Data., Jovan Tanevski, Thin Nguyen, Buu Truong, Nikos Karaiskos, Mehmet Eren Ahsen, Xinyu Zhang, Chang Shu, Ke Xu, Xiaoyu Liang, Ying Hu, Hoang Vv Pham, Li Xiaomei, Thuc D Le, Adi L Tarca, Gaurav Bhatti, Roberto Romero, Nestoras Karathanasis, Phillipe Loher, Yang Chen, Zhengqing Ouyang, Disheng Mao, Yuping Zhang, Maryam Zand, Jianhua Ruan, Christoph Hafemeister, Peng Qiu, Duc Tran, Tin Nguyen, Attila Gabor, Thomas Yu, Justin Guinney, Enrico Glaab, Roland Krause, Peter Banda, Dream Sctc Consortium, Gustavo Stolovitzky, Nikolaus Rajewsky, Julio Saez-Rodriguez, Pablo Meyer

Faculty Research 2020

Single-cell RNA-sequencing (scRNAseq) technologies are rapidly evolving. Although very informative, in standard scRNAseq experiments, the spatial organization of the cells in the tissue of origin is lost. Conversely, spatial RNA-seq technologies designed to maintain cell localization have limited throughput and gene coverage. Mapping scRNAseq to genes with spatial information increases coverage while providing spatial location. However, methods to perform such mapping have not yet been benchmarked. To fill this gap, we organized the DREAM Single-Cell Transcriptomics challenge focused on the spatial reconstruction of cells from the Drosophila embryo from scRNAseq data, leveraging as silver standard, genes with in situ hybridization …

Descriptive Exploration Of Overdose Codes In Hospital And Emergency Department Discharge Data To Inform Development Of Drug Overdose Morbidity Surveillance Indicator Definitions In Icd-10-Cm, Leigh M. Tyndall Snow, Katelyn E. Hall, Cody Curtis, Allison L. Rosenthal, Emilia Pasalic, Sarah Nechuta, James W. Davis, Bretta Jane Jacquemin, Sherani R. Jagroep, Peter Rock, Elyse Contreras, Barbara A. Gabella, Katherine A. James

Peer Reviewed Articles

Background: In October 2015, discharge data coding in the USA shifted to the International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM), necessitating new indicator definitions for drug overdose morbidity. Amid the drug overdose crisis, characterising discharge records that have ICD-10-CM drug overdose codes can inform the development of standardised drug overdose morbidity indicator definitions for epidemiological surveillance.

Methods: Eight states submitted aggregated data involving hospital and emergency department (ED) discharge records with ICD-10-CM codes starting with T36-T50, for visits occurring from October 2015 to December 2016. Frequencies were calculated for (1) the position within the diagnosis billing fields where …

Exercise For Weight Loss: Further Evaluating Energy Compensation With Exercise, Kyle D. Flack, Harry M. Hays, Jack Moreland, Douglas E. Long

Dietetics and Human Nutrition Faculty Publications

PURPOSE: This study assessed how individuals compensate for energy expended during a 12-wk aerobic exercise intervention, elucidating potential mechanisms and the role exercise dose plays in the compensatory response.

PARTICIPANTS AND DESIGN: Three-arm, randomized controlled trial among sedentary adults age 18 to 40 yr, body mass index of 25 to 35. Groups included six exercise sessions per week, two sessions per week, and sedentary control.

METHODS: Rate of exercise energy expenditure was calculated from a graded exercise test averaged across five heart rate zones. Energy compensation was calculated as the difference between expected weight loss (based on exercise energy expenditure) …

Young Children In Deep Poverty: Racial/Ethnic Disparities And Child Well-Being Compared To Other Income Groups, Sheila Smith, Sophie Nguyen, Maribel R. Granja

Graduate School of Education

This report compares early health, development, and risk indicators for young children in deep poverty to indicators for young children in other income groups. The results show that young children in deep poverty experience exceptional challenges that make them vulnerable to poor long-term outcomes. The report also highlights large disparities in the prevalence of deep poverty across five racial/ethnic groups, nationally and state by state.

Inoculation And Amendment Strategies Influence Switchgrass Establishment In Degraded Soil, Ekundayo Adeleke, Kudjo E. Dzantor, Ali Taheri

Agricultural and Environmental Sciences Faculty Research

Bioenergy feedstock production on degraded land can serve as a means for modulating land competition for food versus energy. Due to little or no agricultural value of degraded soil, fortification of the soil with an organic amendment or inoculum will improve biomass productivity. However, as farmers struggle to rejuvenate their degraded land, there is a need for a quick screening strategy to select the best method of enhancing cellulosic (switchgrass, SG) biomass production in degraded soil. The goal of this study is to evaluate the effects of soil amendment and inoculation strategies on biomass productivities of SG in a reclaimed …

Characterizations Of Sars-Cov-2 Mutational Profile, Spike Protein Stability And Viral Transmission, Sayantan Laha, Joyeeta Chakraborty, Shantanab Das, Soumen Kanti Manna, Sampa Biswas, Raghunath Chatterjee

ISI Best Publications

The recent pandemic of SARS-CoV-2 infection has affected more than 3.0 million people worldwide with more than 200 thousand reported deaths. The SARS-CoV-2 genome has the capability of gaining rapid mutations as the virus spreads. Whole-genome sequencing data offers a wide range of opportunities to study mutation dynamics. The advantage of an increasing amount of whole-genome sequence data of SARS-CoV-2 intrigued us to explore the mutation profile across the genome, to check the genome diversity, and to investigate the implications of those mutations in protein stability and viral transmission. We have identified frequently mutated residues by aligning ~660 SARS-CoV-2 genomes …

Laboratory Results And Mathematical Modeling Of Spore Surface Interactions In Stormwater Runoff, Anne M. Mikelonis, Katherine Ratliff, Sungmin Youn

All Engineering Faculty Research

Development of numerical models to predict stormwater-mediated transport of pathogenic spores in the environment depends on an understanding of adhesion forces that dictate detachment after rain events. Zeta potential values were measured in the laboratory for Bacillus globigii and Bacillus thuringiensis kurstaki, two common surrogates used to represent Bacillus anthracis, in synthetic baseline ultrapure water and laboratory prepared stormwater. Zeta potential curves were also determined for materials representative of urban infrastructure (concrete and asphalt). These data were used to predict the interaction energy between the spores and urban materials using Derjaguin-Landau-Verwey-Overbeek (DLVO) modeling. B. globigii and B. thuringiensis kurstaki …

Targeting Glutathione With The Triterpenoid Cddo-Im Protects Against Benzo-A-Pyrene-1,6-Quinone-Induced Cytotoxicity In Endothelial Cells, Halley Shukla, Ho Young Lee, Ashkon Koucheki, Humaira A. Bibi, Gabriella Gaje, Xiaolun Sun, Hong Zhu, Y R. Li, Zhenquan Jia

Osteopathic Medicine, Jerry M. Wallace School of

Epidemiological studies have exhibited a strong correlation between exposure to air pollution and deaths due to vascular diseases such as atherosclerosis. Benzo-a-pyrene-1,6-quinone (BP-1,6-Q) is one of the components of air pollution This study was to examine the role of GSH in BP-1,6-Q mediated cytotoxicity in human EA.hy96 endothelial cells and demonstrated that induction of cellular glutathione by a potent triterpenoid, CDDO-Im (1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole), protects cells against BP-1,6-Q induced protein and lipid damage. Incubation of EA.hy926 endothelial cells with BP-1,6-Q caused a significant increase in dose-dependent cytotoxicity as measured by LDH release assay and both apoptotic and necrotic cell deaths as measured …

Aquatic Beetles Influence Colonization Of Disparate Taxa In Small Lentic Systems, Matthew R. Pintar, William J. Resetarits

Faculty and Student Publications

© 2020 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd Structure of natural communities is shaped by both abiotic characteristics and the ongoing processes of community assembly. Important to this process are the habitat selection behaviors and subsequent survival of colonists, both in the context of temporal changes in the abiotic characteristics and priority effects driven by earlier colonists. Aquatic beetles are prevalent in temporary freshwater systems, form speciose assemblages, and are often early colonists of temporary ponds. While beetles have the potential to influence community structure through post-colonization interactions (predation and competition), our goal was …

Kdm5b Is Essential For The Hyperactivation Of Pi3k/Akt Signaling In Prostate Tumorigenesis, Guoliang Li, Thanigaivelan Kanagasabai, Wenfu Lu, Mike R. Zou, Shang-Min Zhang, Sherly I. Celada, Michael G. Izban, Qi Liu, Tao Lu, Billy R. Ballard, Xinchun Zhou, Samuel E. Adunyah, Robert J. Matusik, Qin Yan, Zhenbang Chen

Biology Student Research

KDM5B (lysine[K]-specific demethylase 5B) is frequently upregulated in various human cancers including prostate cancer. KDM5B controls H3K4me3/2 levels and regulates gene transcription and cell differentiation, yet the contributions of KDM5B to prostate cancer tumorigenesis remain unknown. In this study, we investigated the functional role of KDM5B in epigenetic dysregulation and prostate cancer progression in cultured cells and in mouse models of prostate epithelium–specific mutant Pten/Kdm5b. Kdm5b deficiency resulted in a significant delay in the onset of prostate cancer in Pten-null mice, whereas Kdm5b loss alone caused no morphologic abnormalities in mouse prostates. At 6 months of age, the prostate weight …

The Context And Enactment Of Faith-Based Social Entrepreneurship, Bruce R. Borquist

Business as Mission Theses and Dissertations

Faith-based organisations have been at the forefront of efforts to meet human need and effect positive social change for centuries, and they continue to make significant contributions to social welfare. However, a paucity of empirical research into the nature of faith-based social entrepreneurship limits knowledge and theory development and hinders the effectiveness of faith-based initiatives. In response, this thesis explores how a religious worldview intersects with values, gender and institutional logics to influence social entrepreneurial activity. The thesis thereby aims to develop new theoretical insights into the contextual embeddedness of the process of social entrepreneurship.

Qualitative, interpretive research based on …

Stall Street Journal | November 2020, Jennifer Jacobs

Library Newsletters

No abstract provided.

Economic Contribution Of Agriculture And Food To Arkansas' Gross Domestic Product 1997-2019, Leah English, Jennie Popp, Wayne Miller

AAES Research Reports and Research Bulletins

Agricultural production, processing, and retail industries are major contributors to Arkansas’ GDP. Agriculture contributes to the state economy through direct agricultural production, value-added processing, and agricultural retail activities. The Agriculture and Food Sector, which is comprised of agricultural production, processing, and retail industries, promotes economic strength through various interactions with other industries. The use of non-agricultural goods and services as inputs into the agricultural sector promotes diversified growth in Arkansas’ economy and thus plays a vital role in maintaining economic stability throughout the state. This report 1) compares the relative size of the Agriculture and Food Sector in Arkansas with …

A Mathematical Model Of Risk Factors In Hiv/Aids Transmission Dynamics: Observational Study Of Female Sexual Network In India, S. Saravanakumar, A. Eswari, L. Rajendran, Marwan Abukhaled

Applied Mathematics & Information Sciences

In this paper, a mathematical model for the transmission dynamics of HIV/AIDS epidemic with emphasis on the role of female sex workers is considered. The model is a system of nine nonlinear differential equations that represent nine different groups of an HIV population. A modified approach of the homotopy perturbation method is used to derive an approximate analytical expression for each of the nine different groups that form HIV population. The analytical results are shown to be consistent with the numerical results obtained by the highly accurate fourth-order Runge-Kutta method. The analytical solution will simplify studying the effect of each …

Propagation Of Rayleigh Waves In Layered Elastic Half-Space With Finite Sliding Contact, Navjot Kaur

Applied Mathematics & Information Sciences

The propagation of Rayleigh waves in an orthotropic elastic half-space underlying an orthotropic elastic layer is analysed. The layer and the half-space are considered in finite sliding contact, for which a parameter ξ,(0 ≤ ξ ≤ 1) has been introduced to represent the sliding contact interfaces. The extreme values of ξ correspond to smooth and perfect contact interface, respectively. It was found that the general dispersion equation exhibiting finite sliding contact between the layer and the half-space depends on the sliding parameter. Frequency equations derived by Vinh et al. [1] and Vinh and Anh [2] have been recovered as particular …

A Hybrid Nash Min-Max Approach For Solving Continuous Static Games, Yousria A. Elnaga, Abdullah S. Shalaby, Ali S. Shehab

Applied Mathematics & Information Sciences

This paper addresses a novel structure of continuous static games (CSGs) called hybrid continuous static games (HCSG). These types of games are based on the fact that the game is presented as a hybrid game between multiple players playing independently using Nash equilibrium solutions (NES) and others playing according to a secure concept using Min-Max solutions (MMS). A Nash Min-Max approach was established to solve such genre games. Also, an algorithm for solving Nash Min-Max hybrid continuous static games (NMMHCSG) has been outlined in clear steps. Moreover, a realistic application of four firms selling replaceable products and seeking to maximize …

Compensator Design For Non-Autonomous Linear Control Systems, Sutrima Sutrima, Christiana Rini Indrati, Lina Aryati

Applied Mathematics & Information Sciences

This paper contributes to a design of stabilizing compensators for the stabilizable systems in the class. A strongly continuous quasi semigroup approach is implemented as a generalization of a strongly continuous semigroup for autonomous systems. Stability of the non-autonomous linear control system is identified by a uniformly exponential stability of a strongly continuous quasi semigroup on the state space. The results showed that in the infinite-dimensional state space, if the closed-loop non-autonomous linear control system was stabilizable and detectable, there existed an infinite-dimensional stabilizing compensators for the system. The assigned controller is given by u = Fxˆ where xˆ is …

An Efficient Three-Level Explicit Time-Split Approach For Solving Two-Dimensional Heat Conduction Equation, Eric Ngondiep

Applied Mathematics & Information Sciences

The present paper considers an efficient time-split approach (i.e. a three-level explicit time-split MacCormack scheme) for solving two-dimensional heat conduction equations. Computational cost reduces the two-level explicit MacCormack and splitting. Both stability and convergence of the method are deeply analyzed in L∞(0,T;L2)-norm under a suitable time step restriction. Numerical experiments suggest that the new algorithm is fast, second order accurate in time and fourth order convergent in space. This shows effectiveness of the numerical scheme and improves some well-known results in literature.

Modeling Of Tumor-Immune Competitive System With Saturated Incidence, M. Rajalakshmi, Mini Ghosh

Applied Mathematics & Information Sciences

In this paper, a non-linear mathematical model for tumor-immune system is formulated and analyzed by considering saturated incidence for the interaction between tumor cells and cytotoxic-T lymphocytes (CTLs). It is assumed that both the tumor cells as well as T-helper cells follow logistic growth. In Addition, a time lag exists in the activation of CTLs because of T-helper cells. Existence and stability of different equilibria of the model are discussed in detail. The model is analyzed using the theory of delay differential equations. It was observed that delay played an important role in defining the dynamics of the system. The …

On The Stability Analysis And Solutions Of Fractional Order Pine Wilt Disease Model, A. M. A. El-Sayed, S. Z. Rida, Y. A. Gaber

Applied Mathematics & Information Sciences

In this paper, we present the fractional order model (FOM) for the spread of the PWD. We show that this model possesses non-negative solutions as desired in any population dynamics. We compute the basic reproduction number R0 and illustrate the equilibrium points (EPs) as well as their stability of this model. We apply The Natural-Adomian decomposition method (N-ADM) and fractional Euler method (FEM) to solve this model. The results are compared with those obtained by classical Rung-Kutta (RK4) method in the case of integer order.

Modified Split-Step Theta Milstein Methods For M-Dimensional Stochastic Differential Equation With Respect To Poisson-Driven Jump, Mahmoud A. Eissa, Fenglin Tian, Boping Tian

Applied Mathematics & Information Sciences

Recently, split-step techniques have been integrated with a Milstein scheme to improve the fundamental analysis of numerical solutions of stochastic differential equations (SDEs). Unfortunately, we note that stability conditions of these methods have restrictions on parameters and step-size to preserve mean-square stability and A-stability of SDEs. We construct new general modified spit-step theta Milstein (MSSTM) methods for using on multi-dimensional SDEs in order to overcome these restrictions. We investigate that the numerical methods are mean-square (MS) stable with no restrictions on parameters for all step-size h > 0 when θ ∈ [1/2, 1] and it is proved that the methods with …

The View From Ventress - 2019-20 Academic Year, University Of Mississippi, College Of Liberal Arts

Liberal Arts Newsletters

News from the College of Liberal Arts

Bioinformatics Of Corals: Investigating Heterogeneous Omics Data From Coral Holobionts For Insight Into Reef Health And Resillience, Lenore J. Cowen, Judith Klein-Seetharaman, Hollie M. Putnam

Biological Sciences Faculty Publications

Coral reefs are home to over 2 million species and provide habitat for roughly 25% of all marine animals, but they are being severely threatened by pollution and climate change. A large amount of genomic, transcriptomic and other -omics data from different species of reef building corals, the uni-cellular dinoagellates, plus the coral microbiome (where corals have possibly the most complex microbiome yet discovered, consisting of over 20,000 different species), is becoming increasingly available for corals. This new data present an opportunity for bioinformatics researchers and computational biologists to contribute to a timely, compelling, and urgent investigation of critical factors …

Examining The Relationship Between All-Female Education And Work Outcomes, Angelica Provost

Honors Projects in Management

This thesis is aimed at studying the long-term impact an all-female secondary education has on work outcomes. Most of the current research on an all-female education pertains to current secondary students or those who are in college. There are minimal studies that analyze if one’s educational environment has a long-term influence on their career. This study hypothesized that an all-female secondary education has a long-term impact on job satisfaction, job performance, and job engagement. This impact is manifested through the Big 5 personality traits of conscientiousness and extraversion, as well as the multifaceted personality trait Core Self Evaluation (CSE). While …