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2020

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Diet Of The Blacktip Shark (Carcharhinus Limbatus) In The Northwestern Gulf Of Mexico, Sarah R. Alewijnse, R. J. David Wells Jan 2020

Diet Of The Blacktip Shark (Carcharhinus Limbatus) In The Northwestern Gulf Of Mexico, Sarah R. Alewijnse, R. J. David Wells

Gulf and Caribbean Research

The stomach contents of 90 Blacktip Shark (Carcharhinus limbatus) specimens caught in the northwestern Gulf of Mexico (GOM) were examined. Stomach contents were identified to the lowest possible taxon, and quantified using percent weight, percent number, percent frequency of occurrence, and percent index of relative importance (IRI). Teleosts were the dominant prey group (98.95% IRI), although most were unidentified (61.70% IRI). Of identified teleost species, Atlantic Croaker (Micropogonias undulatus) (28.43% IRI), and Gulf Menhaden (Brevoortia patronus) (2.31% IRI) were the most important. Crustaceans (0.65% IRI), mollusks (0.46% IRI), and elasmobranchs (0.03% IRI) formed a minor …


Pelagic Sargassum Prediction And Marine Connectivity In The Tropical Atlantic, Donald R. Johnson, James S. Franks, Hazel A. Oxenford, Shelly-Ann L. Cox Jan 2020

Pelagic Sargassum Prediction And Marine Connectivity In The Tropical Atlantic, Donald R. Johnson, James S. Franks, Hazel A. Oxenford, Shelly-Ann L. Cox

Gulf and Caribbean Research

Since 2011, pelagic Sargassum has experienced extraordinary blooms in the Tropical Atlantic where a system of persistent but seasonally variable currents has retained and consolidated it in large masses. Although beneficial at sea, principally as a unique pelagic habitat, when Sargassum inundates the nearshore environment it can have catastrophic effects on tourism, fisheries, health, and local ecosystems. Providing advanced warning of arrival dates of large masses of Sargassum is critical for enabling preparations and planning for its removal, use, and mitigation. Predictions of arrival time and location involve satellite identification of Sargassum at sea together with ocean current data for …


Pell-Lucas Collocation Method To Solve High-Order Linear Fredholm-Volterra Integro-Differential Equations And Residual Correction, Şuayi̇p Yüzbaşi, Gamze Yildirim Jan 2020

Pell-Lucas Collocation Method To Solve High-Order Linear Fredholm-Volterra Integro-Differential Equations And Residual Correction, Şuayi̇p Yüzbaşi, Gamze Yildirim

Turkish Journal of Mathematics

In this article, a collocation method based on Pell-Lucas polynomials is studied to numerically solve higher order linear Fredholm-Volterra integro differential equations (FVIDE). The approximate solutions are assumed in form of the truncated Pell-Lucas polynomial series. By using Pell-Lucas polynomials and relations of their derivatives, the solution form and its derivatives are brought to matrix forms. By applying the collocation method based on equally spaced collocation points, the method reduces the problem to a system of linear algebraic equations. Solution of this system determines the coefficients of assumed solution. Error estimation is made and also a method with the help …


Positive Periodic Solutions For A Class Of Second-Order Differential Equations With State-Dependent Delays, Ahleme Bouakkaz, Rabah Khemis Jan 2020

Positive Periodic Solutions For A Class Of Second-Order Differential Equations With State-Dependent Delays, Ahleme Bouakkaz, Rabah Khemis

Turkish Journal of Mathematics

In this paper, we consider a class of second order differential equations with iterative source term. The main results are obtained by virtue of a Krasnoselskii fixed point theorem and some useful properties of a Green's function which allows us to prove the existence of positive periodic solutions. Finally, an example is included to illustrate the correctness of our results.


On Ulam's Type Stability Criteria For Fractional Integral Equations Including Hadamard Type Singular Kernel, Yasemi̇n Başci, Süleyman Öğrekçi̇, Adi̇l Misir Jan 2020

On Ulam's Type Stability Criteria For Fractional Integral Equations Including Hadamard Type Singular Kernel, Yasemi̇n Başci, Süleyman Öğrekçi̇, Adi̇l Misir

Turkish Journal of Mathematics

In this paper, we deal with the Hyers-Ulam-Rassias (HUR) and Hyers-Ulam (HU) stability of Hadamard type fractional integral equations on compact intervals. The stability conditions are developed using a new generalized metric (GM) definition and the fixed point technique by motivating Wang and Lin Ulam's type stability of Hadamard type fractional integral equations. Filomat 2014; 28(7): 1323-1331. Moreover, our approach is efficient and ease in use than to the previously studied approaches. Finally, we give two examples to explain our main results.


Existence Of Self-Similar Solutions To Smoluchowski's Coagulation Equation With Product Kernel, Tanfer Tanriverdi̇ Jan 2020

Existence Of Self-Similar Solutions To Smoluchowski's Coagulation Equation With Product Kernel, Tanfer Tanriverdi̇

Turkish Journal of Mathematics

We explore, by using formal analysis, the existence of mass conserving self-similar solutions for Smoluchowski's coagulation equation when kernel $K(x,y)=x^{\lambda} y^{\mu}+x^{\mu} y^{\lambda}$ with $0


Lerch Matrix Collocation Method For 2d And 3d Volterra Type Integral And Second Order Partial Integro Differential Equations Together With An Alternative Error Analysis And Convergence Criterion Based On Residual Functions, Seda Çayan, Mehmet Sezer Jan 2020

Lerch Matrix Collocation Method For 2d And 3d Volterra Type Integral And Second Order Partial Integro Differential Equations Together With An Alternative Error Analysis And Convergence Criterion Based On Residual Functions, Seda Çayan, Mehmet Sezer

Turkish Journal of Mathematics

In this study, second order linear Volterra partial integro-differential equation with two- and three-dimensional are solved by collocation method based on Lerch polynomials. This method is composed of the operational matrix and collocation methods, which are based upon the matrix forms of the Lerch polynomials with the parameter $\lambda$ and Taylor polynomials, and their derivatives and integrals. The approximate solutions of the mentioned equations are investigated in terms of the Lerch polynomials the different values of $\lambda$. Also, to verify the accuracy and efficiency of the present method, an alternative convergence criterion along with error analysis depending on residual function …


Late Pregnancy Vitamin D Deficiency Is Associated With Doubled Odds Of Birth Asphyxia And Emergency Caesarean Section: A Prospective Cohort Study, Hanna Augustin Olausson, Sinead Mulcahy, Inez Schoenmakers,, Maria Bullarbo, Anna Glantz, Anna Winkvist, Linnea Bärebring Jan 2020

Late Pregnancy Vitamin D Deficiency Is Associated With Doubled Odds Of Birth Asphyxia And Emergency Caesarean Section: A Prospective Cohort Study, Hanna Augustin Olausson, Sinead Mulcahy, Inez Schoenmakers,, Maria Bullarbo, Anna Glantz, Anna Winkvist, Linnea Bärebring

Articles

The aim of this prospective cohort study was to investigate the associations between maternal vitamin D status in late pregnancy and emergency caesarean section (EMCS) and birth asphyxia, in a population based sample of women in Sweden.


Pre-Clinical Models Of Small Cell Lung Cancer And The Validation Of Therapeutic Targets, Jane S.Y. Sui, Petra Martin, Steven G. Gray Jan 2020

Pre-Clinical Models Of Small Cell Lung Cancer And The Validation Of Therapeutic Targets, Jane S.Y. Sui, Petra Martin, Steven G. Gray

Articles

Introduction: Small-cell lung cancer (SCLC) is an aggressive form of lung cancer that has a dismal prognosis. One of the factors hindering therapeutic developments for SCLC is that most SCLC is not surgically resected resulting in a paucity of material for analysis. To address this, significant efforts have been made by investigators to develop pre-clinical models of SCLC allowing for downstream target identification in this difficult to treat cancer.

Areas covered: In this review, we describe the current pre-clinical models that have been developed to interrogate SCLC, and outline the benefits and limitations associated with each. Using examples …


Polarization Of Neural Codes, Katie Christensen, Hamid Kulosman Jan 2020

Polarization Of Neural Codes, Katie Christensen, Hamid Kulosman

Turkish Journal of Mathematics

The neural rings and ideals as an algebraic tool for analyzing the intrinsic structure of neural codes were introduced by C. Curto, V. Itskov, A. Veliz-Cuba, and N. Youngs in 2013. Since then they were investigated in several papers, including the 2017 paper by S. Güntürkün, J. Jeffries, and J. Sun, in which the notion of polarization of neural ideals was introduced. In our paper we extend their ideas by introducing the notions of polarization of motifs and neural codes. We show that the notions that we introduce have very nice properties which allow the studying of the intrinsic structure …


A Reduced Computational Matrix Approach With Convergence Estimation For Solving Model Differential Equations Involving Specific Nonlinearities Of Quartic Type, Ömür Kivanç Kürkçü Jan 2020

A Reduced Computational Matrix Approach With Convergence Estimation For Solving Model Differential Equations Involving Specific Nonlinearities Of Quartic Type, Ömür Kivanç Kürkçü

Turkish Journal of Mathematics

This study aims to efficiently solve model differential equations involving specific nonlinearities of quartic type by proposing a reduced computational matrix approach based on the generalized Mott polynomial. This method presents a reduced matrix expansion of the generalized Mott polynomial with the parameter-$\alpha$, matrix equations, and Chebyshev--Lobatto collocation points. The simplicity of the method provides fast computation while eliminating an algebraic system of nonlinear equations, which arises from the matrix equation. The method also scrutinizes the consistency of the solutions due to the parameter-$\alpha$. The oscillatory behavior of the obtained solutions on long time intervals is simulated via a coupled …


Ruled Surfaces Obtained By Bending Of Curves, Uğur Gözütok, Hüsnü Anil Çoban, Yasemi̇n Sağiroğlu Jan 2020

Ruled Surfaces Obtained By Bending Of Curves, Uğur Gözütok, Hüsnü Anil Çoban, Yasemi̇n Sağiroğlu

Turkish Journal of Mathematics

We consider a first-order infinitesimal bending of a curve in $\mathbb{R}^3$ to obtain a ruled surface. This paper investigates this kind of ruled surfaces and their properties. Also, we obtain conditions for ruled surfaces obtained by bending to be developable.


Extraction Of Protein From Four Different Seaweeds Using Three Different Physical Pre-Treatment Strategies, Jack O'Connor, Steve Meaney, Gwilym A. Williams, Maria Hayes Jan 2020

Extraction Of Protein From Four Different Seaweeds Using Three Different Physical Pre-Treatment Strategies, Jack O'Connor, Steve Meaney, Gwilym A. Williams, Maria Hayes

Articles

Seaweeds are a rich source of protein and can contain up to 47% on the dry weight basis. It ischallenging to extract proteins from the raw biomass of seaweed due to resilient cell-wall complexes.Four species of macroalgae were used in this study-two brown,Fucus vesiculosusandAlaria esculenta,and two red,Palmaria palmataandChondrus crispus. Three treatments were applied individually tothe macroalgal species: (I) high-pressure processing (HPP); (II) laboratory autoclave processing and(III) a classical sonication and salting out method. The protein, ash and lipid contents of the resultingextracts were estimated. Yields of protein recovered ranged from 3.2% forFucus vesiculosuspre-treatedwith high pressure processing to 28.9% protein recovered …


Atmospheric Biodetection Part I: Study Of Airborne Bacterial Concentrations From January 2018 To May 2020 At Saclay, France, Roland Sarda-Estève, Dominique Baisnée, Benjamin Guinot, Gediminas Maineli, John Sodeau, David O'Connor, Jean Pierre Besancenot, Michel Thibaudon, Sara Monteiro, Jean-Eudes Petit, Valérie Gros Jan 2020

Atmospheric Biodetection Part I: Study Of Airborne Bacterial Concentrations From January 2018 To May 2020 At Saclay, France, Roland Sarda-Estève, Dominique Baisnée, Benjamin Guinot, Gediminas Maineli, John Sodeau, David O'Connor, Jean Pierre Besancenot, Michel Thibaudon, Sara Monteiro, Jean-Eudes Petit, Valérie Gros

Articles

Background: The monitoring of bioaerosol concentrations in the air is a relevant endeavor due to potential health risks associated with exposure to such particles and in the understanding of their role in climate. In this context, the atmospheric concentrations of bacteria were measured from January 2018 to May 2020 at Saclay, France. The aim of the study was to understand the seasonality, the daily variability, and to identify the geographical origin of airborne bacteria. Methods: 880 samples were collected daily on polycarbonate filters, extracted with purified water, and analyzed using the cultivable method and flow cytometry. A source receptor model …


Synthesis And Optimisation Of P3 Substituted Vinyl Sulfone-Based Inhibitors As Anti-Trypanosomal Agents, William Doherty, Nikoletta Adler, Andrew Knox, Thomas J. Butler, Paul Evans Jan 2020

Synthesis And Optimisation Of P3 Substituted Vinyl Sulfone-Based Inhibitors As Anti-Trypanosomal Agents, William Doherty, Nikoletta Adler, Andrew Knox, Thomas J. Butler, Paul Evans

Articles

A series of lysine-based vinyl sulfone peptidomimetics were synthesised and evaluated for anti-trypanosomal activity against bloodstream forms of T. brucei. This focused set of compounds, varying in the P3 position, were accessed in a divergent manner from a common intermediate (ammonium salt 8). Several P3 analogues exhibited sub-micromolar EC50 values, with thiourea 14, urea 15 and amide 21 representing the most potent anti-trypanosomal derivatives of the series. In order to establish an in vitro selectivity index the most active anti-trypanosomal compounds were also assessed for their impact on cell viability and cytotoxity effects in mammalian cells. Encouragingly, all compounds only …


Cu(Ii) Phenanthroline-Phenazine Complexes Dysregulate Mitochondrial Function And Stimulate Apoptosis, Garret Rochford, Zara Molphy, Kevin Kavanagh, Malachy Mccann, Michael Devereux, Andrew Kellett, Orla L. Howe Jan 2020

Cu(Ii) Phenanthroline-Phenazine Complexes Dysregulate Mitochondrial Function And Stimulate Apoptosis, Garret Rochford, Zara Molphy, Kevin Kavanagh, Malachy Mccann, Michael Devereux, Andrew Kellett, Orla L. Howe

Articles

Herein we report an in-depth study on the cytotoxic mechanism of action of four developmental cytotoxic copper(II) complexes: [Cu(phen)2]2+ (Cu-Phen); [Cu(DPQ)(Phen)]2+ (Cu-DPQ-Phen); [Cu(DPPZ)(Phen)]2+; and [Cu(DPPN)(Phen)]2+ (where Phen = 1,10-phenanthroline, DPQ = dipyrido[3,2-f:20,30-h]quinoxaline, DPPZ = dipyrido[3,2-a:20,30-c]phenazine, and DPPN = benzo[i]dipyrido[3,2-a:20,30-c]phenazine). This complex class is known for its DNA intercalative properties and recent evidence—derived from an in vivo proteomic study—supports the potential targeting of mitochondrial function. Therefore, we focused on mitochondrial-mediated apoptosis related to cytotoxic activity and the potential impact these agents have on mitochondrial function. The Cu(II) complexes demonstrated superior activity regardless of aromatic extension within the phenazine ligand to the …


Winning Entry For 2020, Avatar Simpson Jan 2020

Winning Entry For 2020, Avatar Simpson

Library Research Prize

No abstract provided.


On Solvability Of Inverse Problem For One Equation Of Fourth Order, Aysel Ramazanova Telman Qizi, Yashar Mehreliyev Topush Oglu Jan 2020

On Solvability Of Inverse Problem For One Equation Of Fourth Order, Aysel Ramazanova Telman Qizi, Yashar Mehreliyev Topush Oglu

Turkish Journal of Mathematics

The work is devoted to study the existence and uniqueness of the classical solution of the inverse boundary value problem of determining the lowest coefficient in one fourth order equation. The original problem is reduced to an equivalent problem. The existence and uniqueness of the integral equation are proved by means of the contraction mappings principle, and we obtained that this solution is unique for a boundary value problem. Further, using these facts, we prove the existence and uniqueness of the classical solution for this problem.


Solution Of Nonlinear Ordinary Differential Equations With Quadratic And Cubic Terms By Morgan-Voyce Matrix-Collocation Method, Mehmet Tarakçi, Mustafa Özel, Mehmet Sezer Jan 2020

Solution Of Nonlinear Ordinary Differential Equations With Quadratic And Cubic Terms By Morgan-Voyce Matrix-Collocation Method, Mehmet Tarakçi, Mustafa Özel, Mehmet Sezer

Turkish Journal of Mathematics

Nonlinear differential equations have many applications in different science and engineering disciplines. However, a nonlinear differential equation cannot be solved analytically and so must be solved numerically. Thus, we aim to develop a novel numerical algorithm based on Morgan-Voyce polynomials with collocation points and operational matrix method to solve nonlinear differential equations. In the our proposed method, the nonlinear differential equations including quadratic and cubic terms having the initial conditions are converted to a matrix equation. In order to obtain the matrix equations and solutions for the selected problems, code was developed in MATLAB. The solution of this method for …


Sorption Of U(Vi) Onto Manganese Oxides In The Presence Of Siderophore Desferrioxamine-B, Morgan Snyder Jan 2020

Sorption Of U(Vi) Onto Manganese Oxides In The Presence Of Siderophore Desferrioxamine-B, Morgan Snyder

Electronic Theses and Dissertations, 2020-2023

Anthropogenic activities, such as uranium mining and the production of nuclear energy and nuclear weapons, have led to significant uranium contamination of the environment, leaving populations vulnerable to negative health effects. In order to effectively remediate uranium contamination, the mobility of uranium in the environment and its natural attenuation through sorption with active mineral phases, needs to be studied in depth first. This study aims to determine how U(VI) mobility is affected by manganese oxides in the presence and absence of siderophore Desferrioxamine-B (DFOB). Experiments focused on two common manganese minerals, pyrolusite (ß-MnO2) and manganite (γ-MnOOH). Adsorption experiments with U(VI)-DFOB …


Introduction Project 400: Our Lived Experience, Ronnie A. Dunn Jan 2020

Introduction Project 400: Our Lived Experience, Ronnie A. Dunn

Cultural Encounters, Conflicts, and Resolutions

No abstract provided.


Therapeutic Plasma Exchange For Neuromyelitis Optica Spectrum Disorder: A Multicenter Retrospective Study By The Asfa Neurologic Diseases Subcommittee, Tina S. Ipe, Jay S. Raval, Leonor P. Fernando, Amit Gokhale, Cyril Jacquot, Andrew D. Johnson, Haewon C. Kim, Grace F. Monis, Yunchun D. Mo, Shanna M. Morgan, Monica B. Pagano, Huy P. Pham, Kimberly Sanford, Amy E. Schmidt, Joseph Schwartz, Jennifer Webb, Jeffrey L. Winters, Yanyun Wu, Chisa Yamada, Edward C C Wong, Amy Waldman Jan 2020

Therapeutic Plasma Exchange For Neuromyelitis Optica Spectrum Disorder: A Multicenter Retrospective Study By The Asfa Neurologic Diseases Subcommittee, Tina S. Ipe, Jay S. Raval, Leonor P. Fernando, Amit Gokhale, Cyril Jacquot, Andrew D. Johnson, Haewon C. Kim, Grace F. Monis, Yunchun D. Mo, Shanna M. Morgan, Monica B. Pagano, Huy P. Pham, Kimberly Sanford, Amy E. Schmidt, Joseph Schwartz, Jennifer Webb, Jeffrey L. Winters, Yanyun Wu, Chisa Yamada, Edward C C Wong, Amy Waldman

Pathology Research and Scholarship

IMPORTANCE: Neuromyelitis optica/neuromyelitis optica spectrum disorder patients' response to therapeutic plasma exchange (TPE) is currently incompletely characterized.

OBJECTIVE: Our study aims to understand the clinical status improvement of neuromyelitis optica/neuromyelitis optica spectrum disorder patients treated with TPE.

DESIGN, SETTING, AND PARTICIPANTS: This is a multicenter retrospective study conducted between 1 January 2003 and 31 July 2017 at 13 US hospitals performing apheresis procedures. Subjects studied were diagnosed with neuromyelitis optica/neuromyelitis optica spectrum disorder who received TPE during presentation with acute disease.

MAIN OUTCOMES AND MEASURES: The primary outcome was clinical status improvement in patients treated with TPE. Secondary measures were …


Changes In Likely Activation Patterns Of Alcohol Expectancies After Exposure To The Expectancy Challenge Alcohol Literacy Curriculum (Ecalc), Jessica Flori Jan 2020

Changes In Likely Activation Patterns Of Alcohol Expectancies After Exposure To The Expectancy Challenge Alcohol Literacy Curriculum (Ecalc), Jessica Flori

Electronic Theses and Dissertations, 2020-2023

Alcohol is the most commonly used substance by adolescents in the United States with underage alcohol use being associated with a variety of harms. The Expectancy Challenge Alcohol Literacy Curriculum (ECALC) is a 45-minute interactive expectancy challenge intervention that has been found to be effective in reducing alcohol use. Although ECALC is thought to produce reductions in drinking by changing expectancies, the nature of these expectancy changes has yet to be explored. The purpose of the present study was to link ECALC outcome studies with a memory model approach to understanding the mechanism by which expectancies influence behavior. Participants (n …


No. 15 An Order Suspending Provisions Of Certain Statutes And Rules And Taking Other Necessary Measures In Order To Facilitate The Treatment And Containment Of Covid-19, Bill Lee Jan 2020

No. 15 An Order Suspending Provisions Of Certain Statutes And Rules And Taking Other Necessary Measures In Order To Facilitate The Treatment And Containment Of Covid-19, Bill Lee

Executive Orders

No abstract provided.


No. 73 An Order To Facilitate The Continued Response To Covid-19 By Extending Executive Order Provisions, Bill Lee Jan 2020

No. 73 An Order To Facilitate The Continued Response To Covid-19 By Extending Executive Order Provisions, Bill Lee

Executive Orders

No abstract provided.


2020-2021 Graduate Catalog, Morehead State University Jan 2020

2020-2021 Graduate Catalog, Morehead State University

Morehead State Catalog Archive

2020-2021 Graduate catalog for Morehead State University.


The Effectiveness Of Cannabidiol In Rheumatic Disease Pain: A Systematic Review, Mary C. Wiczek Jan 2020

The Effectiveness Of Cannabidiol In Rheumatic Disease Pain: A Systematic Review, Mary C. Wiczek

All Graduate Theses, Dissertations, and Other Capstone Projects

Cannabinoids have long been a part of human culture and medicine, and more recently have been rediscovered for their potential use in the management of rheumatic disease pain. The objective of this review was to evaluate the known clinical effectiveness of cannabidiol treatment for rheumatic disease related pain. The legality and current regulation of these products was also reviewed to establish the current status of federal and state rules regarding their clinical use. Basic definitions of the terms used to differentiate cannabidiol from other cannabinoid products was also outlined. A systematic literature search was then conducted to explore the current …


Best Youth Education Methods For Sexually Transmitted Infection Prevention, Caitlin F. Walchonski Jan 2020

Best Youth Education Methods For Sexually Transmitted Infection Prevention, Caitlin F. Walchonski

All Graduate Theses, Dissertations, and Other Capstone Projects

Sexual health education in the United States is inconsistent; information and methods vary from one location to another. Education plays a large role in developing safe sex practices, and despite the sexual education efforts, rates of sexually transmitted infections have risen for five consecutive years in the United States. A systematic literature review was conducted to determine the best methods for educating adolescents to promote behaviors to enhance sexual health. Multiple types of interventions have been studied including cognitive behavioral interventions, comprehensive sexual education, parent and teen dyad education, and abstinence only education. Sexual behavior is influenced by a variety …


Coaching Women On The Impact Of Alcohol Intake On Mental Well-Being: A Systematic Literature Review, Amy Maloney Jan 2020

Coaching Women On The Impact Of Alcohol Intake On Mental Well-Being: A Systematic Literature Review, Amy Maloney

All Graduate Theses, Dissertations, and Other Capstone Projects

Alcohol intake among women has increased in recent years. Women’s bodies metabolize alcohol differently when compared to men and are at increased risk for adverse effects, both physically and mentally. The purpose of this systematic literature review is to explore the evidence related to the impact of coaching in primary care on drinking behaviors and over-all well-being of women. Four databases including PsycInfo, Academic Search Premier, CINAHL Plus with full text, and Gender Studies Database were searched using a variety of key words. Studies were included if they focused on female alcohol use and abuse, interventions specific to female alcohol …


Probiotics And The Prevention Of Clostridioides Difficile: A Review Of Existing Systematic Reviews, Andrea L. Onstad Jan 2020

Probiotics And The Prevention Of Clostridioides Difficile: A Review Of Existing Systematic Reviews, Andrea L. Onstad

All Graduate Theses, Dissertations, and Other Capstone Projects

Clostridioides difficile is the leading cause of infectious diarrhea (Vernaya et al., 2017). Probiotics have been proposed to provide a protective benefit against Clostridioides difficile infection (CDI). The objective of this literature review was to examine the research evidence pertaining to the use of probiotics for the prevention of CDI in individuals receiving antibiotic therapy. A systematic literature review of studies published between 2015 and 2019 was performed. Five databases were searched, which yielded 10 systematic reviews that met strict inclusion criteria. Overall, the majority of evidence indicated that probiotics versus no treatment, placebo, or usual care have the potential …