Digital Commons Network^™

Spatial Memory And Executive Functioning In The Goto-Kakizaki Rat Model Of Diabetes, Lorielle Dietze

Theses and Dissertations (Comprehensive)

Type 2 diabetes mellitus is a disease that adversely affects cognitive function in areas extending to memory and executive functioning. The Goto-Kakizaki (GK) rat provides a model of type 2 diabetes that can illustrate the mechanisms by which this disease works. The present study compared hyperglycaemic GK rats and age-matched Wistar rats in the Morris water maze to assess spatial memory, and in a perceptual attentional set-shifting task to assess putative prefrontal-dependent executive functioning. Results showed there was no difference in path length during training trials, however, GK and Wistar rats differed in the path length travelled in the target …

Using Phytoglycogen-Based Nanoparticles To Enhance Inosine Monophsophate Delivery Using Rainbow Trout And Bovine Models, Kristof Jenik

Theses and Dissertations (Comprehensive)

Recently, there has been interest in the use of nucleotides in industrials feeds, with inosine monophosphate showing the most promising effects on growth and immunity. Rainbow trout and Alberta cattle are two of Canadas most profitable farmed animals, if their growth rates and immunity could be enhanced this would further improve their value. The impacts of IMP, a phytoglycogen-based nanoparticle (NP) and inosine monophosphate cationically bound to the phytoglycogen-based nanoparticle (IMP-NP) were characterized in rainbow trout in vivo and in vitro and in vitro in bovine cells. Rainbow trout that were fed an IMP-NP containing feed on average had higher …

Be Kind To Your Mind: A Randomized Controlled Trial Comparing The Benefits Of Mindfulness And Self-Compassion Vs. Social Skills Training Among Children And Adolescents, Lindsey Feltis

Theses and Dissertations (Comprehensive)

Childhood and adolescence can be difficult for young people as they navigate a variety of significant transitions. Thus, it is imperative that researchers focus on programs that support children and adolescents during this time. Mindfulness and self-compassion are two such programs that may promote positive youth development. Mindfulness and self-compassion have been explored in the adolescent context, and mindfulness has been explored with young children, however research on self-compassion for children is currently lacking. The present studies were designed to examine the feasibility, acceptability and potential benefits of a combined mindfulness + self-compassion program for children and adolescents in the …

Plasmonic Slab Waveguides: Theory & Application For Sensors, Anum Khattak

Theses and Dissertations (Comprehensive)

Through surface plasmon polaritons (SPPs) that propagate along the interface between a metal and a dielectric material, plasmonic waveguides have the ability to confine light at subwavelength scale beyond the diffraction limit, which opens a promising platform to further downsize the active and passive photonic devices. The fields of the SPPs have maximum amplitude at the metal/dielectric interface and decay exponentially toward both media, where the penetration of the fields in the dielectric is very susceptible to the change in the refractive index of the dielectric. This makes surface plasmon resonance (SPR) a remarkable technique in sensor applications to investigate …

Effects And Modes Of Action Of Exogenous Androgens On Gonadal Steroidogenesis In Male Mummichog (Fundulus Heteroclitus), Robert Rutherford

Theses and Dissertations (Comprehensive)

Androgens are a recognized class of endocrine disrupting compounds that are introduced into the aquatic environment through a variety of anthropogenic sources. Exogenous androgens can interact with the hypothalamus-pituitary-gonadal (HPG) axis in fish and alter its normal function, resulting in effects such as skewed sex ratios, intersex individuals, reduced fecundity, or altered mating behaviours. In fish, these apical effects are commonly correlated to depression of the terminal sex hormones testosterone, 17β-estradiol and 11-ketotestosterone (11KT). It is currently thought that the reduction in plasma sex hormones is an effect of negative feedback inhibition of steroid synthesis within the HPG axis after …

Prognostic Impact Of Cdkn2a/B Deletion, Tert Mutation, And Egfr Amplification On Histological And Molecular Idh-Wildtype Glioblastoma, Sirui Ma, Soumon Rudra, Jian L Campian, Sonika Dahiya, Gavin P Dunn, Tanner Johanns, Michael Goldstein, Albert H Kim, Jiayi Huang

2020-Current year OA Pubs

BACKGROUND: We aimed to evaluate the clinical outcomes of molecular glioblastoma (mGBM) as compared to histological GBM (hGBM) and to determine the prognostic impact of

METHODS: IDH-wildtype GBM patients treated with radiation therapy (RT) between 2012 and 2019 were retrospectively analyzed. mGBM was defined as grade II-III IDH-wildtype astrocytoma without histological features of GBM but with one of the following molecular alterations:

RESULTS: Of the 367 eligible patients, the median follow-up was 11.7 months. mGBM and hGBM did not have significantly different OS (median: 16.6 vs 13.5 months, respectively,

CONCLUSION: Criteria for mGBM may require further refinement and validation.

Preparation And Optimization Of Rapid And Sensitive Coagglutination Test For Detection Ofinfectious Pancreatic Necrosis Virus (Ipnv), Kemal Pekmez, Gülnur Kalayci, Sai̇me İsmet Gürhan, Eli̇f Esi̇n Tuna

Turkish Journal of Veterinary & Animal Sciences

The aim of this study is the development of a coagglutination test for rapid diagnosis of infectious pancreatic necrosis (IPN) virus which causes an acute infectious viral disease with high mortality in young salmonid fish. Serotypes Sp, Ab, WB of the IPNV were cultivated in BF-2 cells and purified by linear sucrose density gradient centrifugation. Hyperimmune sera against purified IPNV serotypes were collected from immunized guinea pigs. Coagglutination test conjugates were prepared by using sensitized S. aureus and hyperimmune sera. Cell culture derived salmonid pathogens such as infectious hematopoietic necrosis virus (IHNV), viral haemorrhagic septicaemia virus (VHSV) and epizootic hematopoietic …

Digforce: Digital Forensics For Cyber Enforcement At Dakota State University Working Towards Public-Private Cybercrime Investigations, Ashley Podhradsky, Francisca Opoku-Boateng, Arica Kulm, Trevor Jones

South Dakota Law Review

No abstract provided.

Acknowledgement Entity Recognition In Cord-19 Papers, Jian Wu, Pei Wang, Xin Wei, Sarah Rajtmajer, C. Lee Giles, Christopher Griffin

Computer Science Faculty Publications

Acknowledgements are ubiquitous in scholarly papers. Existing acknowledgement entity recognition methods assume all named entities are acknowledged. Here, we examine the nuances between acknowledged and named entities by analyzing sentence structure. We develop an acknowledgement extraction system, AckExtract based on open-source text mining software and evaluate our method using manually labeled data. AckExtract uses the PDF of a scholarly paper as input and outputs acknowledgement entities. Results show an overall performance of F₁=0.92. We built a supplementary database by linking CORD-19 papers with acknowledgement entities extracted by AckExtract including persons and organizations and find that only up to …

Opening Books And The National Corpus Of Graduate Research, William A. Ingram, Edward A. Fox, Jian Wu

Computer Science Faculty Publications

Virginia Tech University Libraries, in collaboration with Virginia Tech Department of Computer Science and Old Dominion University Department of Computer Science, request $505,214 in grant funding for a 3-year project, the goal of which is to bring computational access to book-length documents, demonstrating that with Electronic Theses and Dissertations (ETDs). The project is motivated by the following library and community needs. (1) Despite huge volumes of book-length documents in digital libraries, there is a lack of models offering effective and efficient computational access to these long documents. (2) Nationwide open access services for ETDs generally function at the metadata level. …

Granulosa Cell Proliferation Is Inhibited By Pge2 In The Primate Ovulatory Follicle, Patric S. Lundberg, Gil J. Moskowitz, Carmel Bellacose, Esra Demirel, Heidi A. Trau, Diane M. Duffy

Computer Science Faculty Publications

Prostaglandin E2 (PGE2) is a key paracrine mediator of ovulation. Few specific PGE2-regulated gene products have been identified, so we hypothesized that PGE2 may regulate the expression and/or activity of a network of proteins to promote ovulation. To test this concept, Ingenuity Pathway Analysis (IPA) was used to predict PGE2-regulated functionalities in the primate ovulatory follicle. Cynomolgus macaques underwent ovarian stimulation. Follicular granulosa cells were obtained before (0 h) or 36 h after an ovulatory dose of human chorionic gonadotropin (hCG), with ovulation anticipated 37-40 h after hCG. Granulosa cells were obtained from additional monkeys 36 h after treatment with …

Stable Carbon And Oxygen Isotopes As Environmental Indicators Of The Late Pleistocene Inel Arenoso, Sonora, Northwest Mexico, Victor Adrian Perez Crespo, Tamara Cruz Y Cruz, Alejandro Terrazas Mata, Pedro Morales Puente, Martha Benavente, Edith Cienfuegos-Alvrado, Francisco J. Otero

Turkish Journal of Earth Sciences

The paleoenvironment conditions that existed in the Late Pleistocene at the archaeological-paleontological site of El Arenoso, Sonora, NW Mexico, were inferred using the carbon and oxygen stable isotopes from one bison, one mammoth, and thirteen horses as well as the pedological characteristics and the carbon isotopes of calcium carbonates from paleosoil. The values δ13C of the bison (-1.4‰), the horses (-2.8‰), and the mammoth (-4.3‰) show that these animals fed mainly on C4 plants and carbon isotopic values from profile horizons of locality 4Bgk (-3.4‰), 3Ck (-3.4‰), and 2Bgk2 (-5.7‰) indicated the presence of C3/C4 vegetation mixed in El Arenoso. …

Paleoecological Insights On Latest Oligocene-Early Miocene Planktonic Foraminifera From The J-Anomaly Ridge (Iodp Hole U1406a), Alessio Fabbrini, Luca Maria Foresi

Turkish Journal of Earth Sciences

This paper focuses on a paleoecological study conducted on planktonic foraminifera from upper Oligocene-lower Miocene deposits of the J-Anomaly Ridge (North Atlantic Ocean). Paleoclimatic studies are crucial to better comprehend how climatic changes occurred in the past and how they might influence global climate in the next few decades. Oceanic currents are the predominant vehicle for heat transport across the globe and therefore organisms living within the water mass can supply much information on paleoceanographic settings. In total, 53 samples from IODP Hole U1406A were selected in the core interval 96-24 CCSF-M to perform statistical analyses (R-mode cluster analysis, principal …

Determining The Lake Protected Zones Using Gis-Based Drastic Model To Groundwatervulnerability In Salda Lake Basin (Burdur/Turkey), Si̇mge Varol, Ayşen Davraz, Erhan Şener, Şehnaz Şener, Fatma Aksever, Bülent Kirkan, Ahmet Tokgözlü

Turkish Journal of Earth Sciences

Groundwater quality is a crucial parameter for sustainable wetland management. The evaluation of the aquifer vulnerability is important for the protection of groundwater resources. The DRASTIC model is the most significant technique for the assessment of aquifer vulnerability. This study aimed to build a vulnerability map for groundwater of the Salda Lake wetland basin by DRASTIC method in a GIS environment. Seven environmental parameters (depth to water table, net recharge, aquifer media, soil media, topography, impact of the vadose zone media, and hydraulic conductivity of the aquifer) were used in the DRASTIC method and GIS was used to constitute a …

Genetic Alterations In B Cell Lymphoma Subtypes As Potential Biomarkers For Noninvasive Diagnosis, Prognosis, Therapy, And Disease Monitoring, Esra Esmeray, Can Küçük

Turkish Journal of Biology

Neoplastic transformation of germinal center B (GCB) cells may give rise to a variety of different B cell lymphoma subtypes, most of which show substantial heterogeneity in terms of genetic alterations and clinical features. The mutations observed in cancer-related genes in GCB cells are related to abnormalities in the immunogenetic mechanisms associated with germinal center reaction. Recent studies have rapidly identified genomic alterations in B cell lymphomas that may be useful for better subclassification, noninvasive diagnosis, and prediction of response to therapy. The WHO recognizes different lymphoma subsets classified within 2 major categories of B cell lymphoma: Hodgkin's lymphoma (HL) …

Doxorubicin Inhibits Mir-140 Expression And Upregulates Pd-L1 Expression In Hct116 Cells, Opposite To Its Effects On Mda-Mb-231 Cells, Noel Mopouguini Naba, Nazi̇fe Tolay, Mehmet Batu Erman, Ayça Sayi Yazgan

Turkish Journal of Biology

One of the most challenging problems in colorectal cancer (CRC) is resistance to chemotherapy drugs such as doxorubicin (DOX). The programmed death ligand-1 (PD-L1) is related to chemoresistance and is overexpressed in several human cancer cell types. Here, we investigated the changes in the expression of PD-L1 in DOX-treated CRC and breast cancer (BRC) cells. Also, to address PD-L1 regulation, we assessed expression levels of miR-140 and miR-34a, two microRNAs that can target the 3' UTR region of the gene encoding PD-L1. HCT116 CRC and MDA-MB-231 BRC cells were treated with various doses of DOX in culture and PD-L1 expression …

The Effect Of R547, A Cyclin-Dependent Kinase Inhibitor, On Hepatocellular Carcinoma Cell Death, Betül Hacioğlu, Gökhan Kuş, Hati̇ce Mehtap Kutlu, Selda Kabadere

Turkish Journal of Biology

Hepatocellular carcinoma (HCC) is the third main cause of cancer-related death. Cyclin-dependent kinases (CDKs) and their cyclin partners regulate the cell cycle. Since inhibition of CDKs gives some guiding ideas for cancer studies, we aimed to determine the possible effects of R547, a cyclin kinase 1-2-4 inhibitor, on proliferation and apoptotic mechanisms of Hep G2 cells (human) and H-4- II-E cells derived from rat HCC. We determined in vitro survival rates with MTT assay, apoptosis with flow cytometry, morphological changes with confocal microscopy, and ultrastructural changes by transmission electron microscopy. Cisplatin was used as a positive control. After 24 h …

Pterostilbene Administration Improves The Recovery Potential Of Extremely Low-Frequency Magnetic Field In Acute Renal Ischemia-Reperfusion Injury: An Ftir Spectroscopic Study, Hati̇ce Keser, Özlem Bozkurt Gi̇ri̇t, Muhammed Majeed, Mahadeva Nayak, Mehmet Di̇nçer Bi̇lgi̇n

Turkish Journal of Biology

Renal ischemia-reperfusion (I/R) injury, one of the drastic outcomes of renal failure and organ transplantation, tends to deteriorate over time; therefore, noninvasive therapeutic strategies will avail the progression-free survival of the patients. Magnetic field has been proposed as a noninvasive treatment strategy; however, with recent scientific advances, many controversies have arisen regarding its efficacy. Pterostilbene, a natural analog of resveratrol, was documented to be effective in treatment of I/R injuries. This study aims to assess the acute therapeutic effects of combined extremely low-frequency magnetic field (ELF-MF) and pterostilbene treatment on renal I/R injury. After induction of renal I/R in Wistar …

Comparison Of Unmanaged And Managed Trojan Fir-Scots Pine Forests For Structuralcomplexity, Ferhat Kara, John M. Lhotka

Turkish Journal of Agriculture and Forestry

Unmanaged forests may exhibit a higher degree of biodiversity compared to managed forests. We examined and compared the stand structure, density, and volume of deadwood components of managed and unmanaged mixed forests of Trojan fir (Abies nordmanniana subsp. equi-trojani [Asch. & Sint. ex Boiss] Coode & Cullen)-Scots pine (Pinus sylvestris L.) in northern Turkey. The single-tree selection method has been employed in the managed forests. Density of large live trees ha-1, density of standing deadwood (SDW) ha-1, and volume of lying deadwood (LDW) (m3 ha-1) were calculated for both treatments (i.e. managed or unmanaged). Results showed that unmanaged forests had …

Astragalus Membranaceus And Punica Granatum Alleviate Infertility And Kidney Dysfunction Induced By Aging In Male Rats, Ameera Alshinnawy, Wael Elsayed, Alshaimaa Taha, Ahmed Sayed, Ahmed Salem

Turkish Journal of Biology

By aging, male fertility and kidney function decline. Therefore, the investigation of health span-extending agents becomes more urgent to overcome aging-induced infertility and kidney dysfunction. The current research was undertaken to investigate the antiaging efficacy of Astragalus membranaceus telomerase activator-65 (Ta-65) and pomegranate supplements. Forty male Wistar rats were divided into young rats, aged rats, aged rats treated with Ta-65 (500mg/kg/day), and aged rats treated with pomegranate (250mg/kg/day). Testosterone, FSH, LH, and kidney functions were measured in serum. Sperm analysis as well as testicular histological examination was performed. Aging caused an imbalance in male sex hormones resulting in sperm abnormality …

Two Boron-Containing Compounds Affect The Cellular Viability Of Sh-Sy5y Cells In An In Vitro Amyloid-Beta Toxicity Model, Mehmet Ozansoy, Mehmet Özgen Altintaş, Muzaffer Beyza Ozansoy, Necmeddi̇n Günay, Ertuğrul Kiliç, Ülkan Kiliç

Turkish Journal of Biology

Boron is a naturally occurring trace element found in organic and inorganic complexes. Boron-containing compounds are required for living organisms for diverse metabolic functions, including nitrogen fixation in microorganisms, cell wall stability in plants, and bone and carbohydrate metabolism in animals. The number of studies about the effect of boron in biological model systems is very limited; so far, there has been no study on the correlation between boron and amyloid-beta toxicity. Here, we investigated the possible effects of 2 boron-containing compounds-sodium borate decahydrate and boric acid-against amyloid-beta toxicity. In our in vitro amyloid-beta toxicity model, we showed that these …

Cover And Contents

Turkish Journal of Biology

No abstract provided.

The Effect Of Nitrogen Applications On The Growth Of Young Olive Trees And Nitrogen Useefficiency, Isabel Ferreira, Margari̇da Arrobas, José Moutinho-Pereira, Carlos M. Correia, Manuel Angelo Rodrigues

Turkish Journal of Agriculture and Forestry

Two field trials (FieldExp1 and FieldExp2) and a pot experiment (PotExp) were c0onducted over a period of 3 years to assess olive tree response to nitrogen (N) applications and to estimate apparent N recovery. FieldExp1 was installed in a 3-year-old olive grove. FieldExp2 consisted of a plantation of young rooted plants. Two treatments were applied in both experiments: N application and a nonfertilized control. In PotExp, 4 N rates were used. In FieldExp1, olive yield significantly increased with applied N in only 1 of the 3 growing seasons. In FieldExp2, aboveground dry matter yield significantly increased with N application. In …

Evaluation Of Some Melon Lines For Their Resistance Against Melon Aphid,Aphis Gossypii Glover, Musa Kirişik, Mi̇ne Ünlü, Fedai̇ Erler

Turkish Journal of Agriculture and Forestry

The melon aphid, Aphis gossypii Glover (Hemiptera: Aphididae), which has a very wide host range including cucurbit species, causes serious direct and indirect damage to many crops. In both greenhouse and open field melon cultivation in Antalya (in southwestern Turkey), the control of this pest generally depends on the use of chemical insecticides, resulting in a rapid increase in resistance to a wide range of insecticides. In the present study, a total of 23 melon lines (22 indigenous and 1 exotic) belonging to 2 varieties (Cucumis melo var. inodorus and C. melo var. reticulatus) were evaluated for resistance to the …

Expression Pattern Of Olfactory Receptor Genes In Human Cumulus Cells As An Indicator For Competent Oocyte Selection, Neda Daei-Farshbaf, Reza Aflatoonian, Fatemeh-Sadat Amjadi, Sara Taleahmad, Mahnaz Ashrafi, Mehrdad Bakhtiyari

Turkish Journal of Biology

Odorant or olfactory receptors are mainly localized in the olfactory epithelium for the perception of different odors. Interestingly, many ectopic olfactory receptors with low expression levels have recently been found in nonolfactory tissues to involve in local functions. Therefore, we investigated the probable role of the olfactory signaling pathway in the surrounding microenvironment of oocyte. This study included 22 women in intracytoplasmic sperm injection cycle. The expression of olfactory target molecules in cumulus cells surrounding the growing and mature oocytes was evaluated by Western blotting and real-time polymerase chain reaction. Additionally, integrated bioinformatics analyses were carried out and 6 ectopic …

Epibrassinolide Activates Akt To Trigger Autophagy With Polyamine Metabolism In Sw480 And Dld-1 Colon Cancer Cell Lines, Kaan Adacan, Pinar Obakan Yerli̇kaya

Turkish Journal of Biology

Epibrassinolide (EBR), a plant-derived polyhydroxylated derivative of 5?-cholestane, structurally shows similarities to animal steroid hormones. According to the present study, EBR treatment triggered a significant stress response via activating ER stress, autophagy, and apoptosis in cancer cells. EBR could also increase Akt phosphorylation in vitro. While the activation of Akt resulted in cellular metabolic activation in normal cells to proceed with cell survival, a rapid stress response was induced in cancer cells to reduce survival. Therefore, Akt as a mediator of cellular survival and death decision pathways is a crucial target in cancer cells. In this study, we determined that …

The Inhibitory Effect Of Melatonin On Osteoclastogenesis Of Raw 264.7 Cells In Low Concentrations Of Rankl And Mcsf, Hala Jarrar, Damla Çeti̇n Altindal, Menemşe Gümüşdereli̇oğlu

Turkish Journal of Biology

RAW 264.7 cells are one of the most recommended cell lines for investigating the activity and differentiation of osteoclasts. These cells differentiate into osteoclasts in the presence of two critical components: receptor activator of nuclear factor kappa B ligand (RANKL) and macrophage colony stimulating factor (MCSF). Melatonin (MEL) hormone has recently become one of the small molecules used in the field of bone regeneration and bone disease treatment, as it has the ability to inhibit the differentiation of osteoclasts directly by suppression of the NF-κB signaling pathway. The main aim of the current study is to determine sufficient RANKL/MCSF concentrations …

Cover And Contents

Turkish Journal of Biology

No abstract provided.

Determination Of Some Physicomechanical And Biochemical Parameters Of Hazelnut (Corylus Avellana L.) Cultivars, Necati̇ Çeti̇n, Mehmet Yaman, Kevser Karaman, Bünyami̇n Demi̇r

Turkish Journal of Agriculture and Forestry

Hazelnut is one of the most popular nuts consumed by people; it has different cultivars in Turkey. The aim of the current study was to characterize some physicomechanical characteristics, shape features, color, and biochemical properties of 6 standard and 3 local hazelnut cultivars grown in Turkey. The shape and size properties of the samples were determined using image processing techniques as an alternative to conventional measurement methods. Additionally, principal component analysis (PCA) was used to classify the hazelnut samples in terms of the biochemical parameters of the hazelnut cultivars. According to the findings, the highest crude oil (63.25%) and lowest …

Larvicidal Effect Of Achillea Biebersteinii Afan. (Asteraceae) Essential Oil Against Larvaeof Pine Processionary Moth, Thaumetopoea Pityocampa (Denis & Schiffermüller, 1775)(Lepidoptera: Notodontidae), Memi̇ş Kesdek, Şaban Kordali, Ayşe Usanmaz Bozhüyük, Melek Güdek

Turkish Journal of Agriculture and Forestry

The pine processionary moth, Taumetopoea pityocampa (Denis & Schiffermüller, 1775) (Lepidoptera: Notodontidae), is an important pest of coniferous trees in the forests of Turkey and throughout the world. In order to control this pest, different methods such as mechanical, biological, and chemical control have been used. However, this pest is still a major problem in Turkey, as well as globally. The study aimed to investigate the larvicidal effect of essential oil obtained from Achillea biebersteinii Afan. (Asteraceae) in different doses (10, 15, and 20 μL Petri-1) over time (12, 24, 36, and 48 h) against T. pityocampa larvae in laboratory …