Digital Commons Network^™

Prognostic Molecular Signatures For Metastatic Potential In Clinically Low-Risk Stage I And Ii Clear Cell Renal Cell Carcinomas, A. J. Shih, N. Murphy, Z. Kozel, O. Yaskiv, A. Liew, L. Kavoussi, S. Hall, M. Vira, X. Zhu, A. T. Lee, +2 Additional Authors

Journal Articles

No abstract provided.

Intramuscular Injection Of Vectorized-Scfvmc1 Reduces Pathological Tau In Two Different Tau Transgenic Models, F. Vitale, J. Ortolan, B. T. Volpe, P. Marambaud, L. Giliberto, C. D'Abramo

Journal Articles

No abstract provided.

Expression And Function Of Cathelicidin Hcap18/Ll-37 In Chronic Lymphocytic Leukemia., E. Podaza, F. Palacios, D. O. Croci, D. Risnik, X. J. Yan, M. B. Almejún, A. Colado, E. E. Elías, N. Chiorazzi, M. Giordano, +6 Additional Authors

Journal Articles

No abstract provided.

Sars-Cov-2 And Interferon Blockade, B. Diamond, B. T. Volpe, S. Vanpatten, Y. Al Abed

Journal Articles

© 2020, The Author(s). The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. This model has therapeutic implications.

Association Of Anticoagulation Dose And Survival In Hospitalized Covid-19 Patients: A Retrospective Propensity Score-Weighted Analysis, F. Ionescu, I. Jaiyesimi, I. Petrescu, P. R. Lawler, E. Castillo, Y. Munoz-Maldonado, Z. Imam, M. Narasimhan, A. E. Abbas, G. B. Nair, +1 Additional Author

Journal Articles

© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Background: Hypercoagulability may contribute to COVID-19 pathogenicity. The role of anticoagulation (AC) at therapeutic (tAC) or prophylactic doses (pAC) is unclear. Objectives: We evaluated the impact on survival of different AC doses in COVID-19 patients. Methods: Retrospective, multi-center cohort study of consecutive COVID-19 patients hospitalized between March 13 and May 5, 2020. Results: A total of 3480 patients were included (mean age, 64.5 years [17.0]; 51.5% female; 52.1% black and 40.6% white). 18.5% (n = 642) required intensive care unit (ICU) stay. 60.9% received pAC (n …

Pathophysiology And Pathology Of Acute Kidney Injury In Patients With Covid-19, J. H. Ng, V. Bijol, M. A. Sparks, M. E. Sise, H. Izzedine, K. D. Jhaveri

Journal Articles

© 2020 National Kidney Foundation, Inc. Acute kidney injury (AKI) is common among hospitalized patients with Coronavirus Infectious Disease 2019 (COVID-19), with the occurrence of AKI ranging from 0.5% to 80%. The variability in the occurrence of AKI has been attributed to the difference in geographic locations, race/ethnicity, and severity of illness. AKI among hospitalized patients is associated with increased length of stay and in-hospital deaths. Even patients with AKI who survive to hospital discharge are at risk of developing chronic kidney disease or end-stage kidney disease. An improved knowledge of the pathophysiology of AKI in COVID-19 is crucial to …

A Case Of Wernicke's Encephalopathy In A Pregnant Woman With A History Of Sleeve Gastrectomy., H. Kandlakunta, D. Gurala, J. Philipose, A. Polavarapu, J. R. Abergel

Journal Articles

Wernicke's encephalopathy (WE) is a neurological complication of thiamine deficiency characterized by a triad of acute confusion, ataxia, and ophthalmoplegia. Even though it is most common in chronic alcoholism, an increase in prevalence has been reported recently due to the increased popularity of bariatric surgeries. WE is a known neurological complication after gastric bypass surgery but rarely reported after sleeve gastrectomy. We present a unique case of WE in pregnant women four months after sleeve gastrectomy.

Assessing Health Professionals’ Perception Of Health Literacy In Rhode Island Community Health Centers: A Qualitative Study, Mary L. Greaney, Sherrie F. Wallington, Sankeerth Rampa, Vivian S. Vigliotti, Carol A. Cummings

Public Health Faculty Publications

Background: Limited health literacy is linked with poor health behaviors, limited health care access, and poor health outcomes. Improving individual and population health outcomes requires understanding and addressing barriers to promoting health literacy.

Methods: Using the socio-ecological model as a guiding framework, this qualitative study (Phase 1 of a larger ongoing project) explored the interpersonal and organizational levels that may impact the health literacy levels of patients seeking care at federally qualified community health centers (FQCHCs) in Rhode Island. Focus groups were conducted with FQCHC employees (n = 37) to explore their perceptions of the health literacy skills of …

How Far Is Your Love?, Milo A. Rediger

Milo Rediger Writings & Addresses

No abstract provided.

Examining Variation In Intentional Cranial Modification In Ancient Tucume, Peru, Sarah Wenger

Honors Undergraduate Theses

The purpose of this research is to analyze intentional cranial modification at the site of Túcume located in Peru. Intentional cranial modification is the permanent alteration of the infant cranium through the use of apparatuses that will alter the shape of the skull resulting in lifelong implications. This analysis serves to answer three research questions through testing the hypotheses in regards to the variation among individuals, the sex-based differences in the population, and how cranial modification patterns differentiate normal burials from sacrificed individuals at Túcume. The data include a total of 480 individuals with 375 crania observable. It was found …

An Evaluation Of Co-Culture Parameters Effecting Antibiotic Production In Soil Microbes, Rebecca Lindow

Master's Theses and Doctoral Dissertations

The rise of infections caused by antibiotic resistant bacteria, compounded by a reduction in antibiotic discovery and development, jeopardizes human health. Historically, antibiotics derive from secondary metabolites produced by soil microbes in pure culture, but recent genetic evidence suggests that microbes can produce more secondary metabolites than are currently observed. The modified crowded plate technique directly identifies antibiotic-producing soil microbes that were co-plated with a target pathogen. Here, this technique was refined by testing the effect of a D-alanine auxotrophic target pathogen rather than a prototrophic pathogen as well as investigating conditions most conducive to antibiotic production. Antibiotic producing conditions …

Precarious Womanhood: Maternal Instinct’S Role In Gender-Related Anxiety, Chelsey Kanipe

Master's Theses and Doctoral Dissertations

The phenomenon of “precarious manhood” suggests that when a man perceives a threat to his masculinity, he will respond with anxiety and will subsequently increase his displays of traditional masculinity. The main purpose of this study is to address a parallel phenomenon in women (i.e., “precarious womanhood”), the existence of which previous authors have dismissed. Participants were randomly assigned to receive either high scores, low scores, or no scores following a supposed maternal instinct questionnaire. Then, their subsequent mood and gender identity endorsement were measured via self-report. It was hypothesized that, compared to participants who received either high or no …

2020 Commencement Program, Seattle University

Commencement Programs

No abstract provided.

Neuronal-Derived Extracellular Vesicles Are Enriched In The Brain And Serum Of Hiv-1 Transgenic Rats, Raghubendra S. Dagur, Ke Liao, Susmita Sil, Fang Niu, Zhiqiang Sun, Yuri L. Lyubchenko, Eric S. Peebles, Guoku Hu, Shilpa Buch

Journal Articles: Pharmaceutical Sciences

Despite the efficacy of combination antiretroviral therapy (ART) in controlling human immunodeficiency virus (HIV-1) replication, cytotoxic viral proteins such as HIV-1 transactivator of transcription (Tat) persist in tissues such as the brain. Although HIV-1 does not infect neuronal cells, it is susceptible to viral Tat protein-mediated toxicity, leading to neuroinflammation that underlies HIV-associated neurocognitive disorders (HAND). Given the role of extracellular vesicles (EVs) in both cellular homoeostasis and under pathological conditions, we sought to investigate the alterations in the quantity of neuronal-derived EVs in the brain–as defined by the presence of cell adhesion molecule L1 (L1CAM) and to evaluate the …

The Current State Of Drug Repurposing And Rare Diseases: An Interview With Paul Trippier, Paul C. Trippier

Journal Articles: Pharmaceutical Sciences

Paul Tripper is an Associate Professor of Medicinal Chemistry at the University of Nebraska Medical Center (UNMC, NE, USA) and an Editorial Board member of Future Drug Discovery. Here, he speaks to Managing Editor Francesca Lake about drug repurposing, focusing on the key challenges, its application to rare diseases and what we can look forward to in the future.

11th–12th Grade: English Level 2, Learning Packet #4 • Theme: Martin Luther King, Jr., Trevin Wurm, Aaron P. Johnson, Alexa Yunes

ICMEE Learning Packets: Level 2 of English Proficiency (K-12)

Day 1 • Journal: who is an important person from your country's history?, Who was Martin Luther King, Jr.?, Science: Draw a picture of your favorite animal, Animal adaptations

Day 2 • Journal: who inspires you in your life?, Compound sentences, Science: Physical adaptations: camouflage

Day 3 • Journal: what is a dream you have for your life?, Analyzing a quote, Science: Butterflies from Wappingers Schools

Day 4 • Looking at a protest, The March on Washington, Science: Great white shark, elephants

Day 5 • Journal: what is an important event in the history of your country?, Drawing a protest, …

Legalizing The Meaning Of Meat, Steph Tai

Loyola University Chicago Law Journal

What we call meat has become a contentious issue in the United States. This Article is the first to explore the many dynamics behind meat labeling laws proposed by various state legislatures. It uses food studies methods to places those debates within a larger context of the history of “meat” and plant-based proteins, as well as other food labeling struggles. The Article ultimately argues that expressly recognizing these dynamics can augment sustainable food advocacy efforts in the future.

Surgical Gps Proof Of Concept For Scoliosis Surgery, Austin Tapp, Michel Audette

Computational Modeling & Simulation Engineering Faculty Publications

Scoliotic deformities may be addressed with either anterior or posterior approaches for scoliosis correction procedures. While typically quite invasive, the impact of these operations may be reduced through the use of computer-assisted surgery. A combination of physician-designated anatomical landmarks and surgical ontologies allows for real-time intraoperative guidance during computer-assisted surgical interventions. Predetermined landmarks are labeled on an identical patient model, which seeks to encompass vertebrae, intervertebral disks, ligaments, and other soft tissues. The inclusion of this anatomy permits the consideration of hypothetical forces that are previously not well characterized in a patient-specific manner. Updated ontologies then suggest procedural directions throughout …

Monarch Science Observer, Volume 2, College Of Sciences, Old Dominion University

College of Sciences Newsletter

Winter 2020, issue of Monarch Science Observer, ODU Colleges of Sciences Newsletter.

A Million Kinds Of Happiness, Karina Andrew

Inscape

Monday. Sunny. Low of 68. High of 94. Nineteen percent chance of rain.

The scent of dirt follows me into the house. People say “dirty” like it’s a bad thing, but I like dirt. It clings to me, to the knees of my jeans, to the undersides of my nails, to all the tiny lines and crevices in my skin.

Sweat And Saliva Cortisol Response To Stress And Nutrition Factors, Peter Pearlmutter, Gia Derose, Cheyenne Samson, Nicholas Linehan, Yuqiao Cen, Lina Begdache, Daehan Won, Ahyeon Koh

Health & Wellness Studies Faculty Scholarship

Cortisol is a biomarker for stress monitoring; however, the biomedical and clinical relevance is still controversial due to the complexity of cortisol secretion mechanisms and their circadian cycles as well as environmental factors that afect physiological cortisol level, which include individual mood and dietary intake. To further investigate this multifaceted relationship, a human pilot study examined cortisol concentration in sweat and saliva samples collected from 48 college-aged participants during aerobic exercise sessions along with mental distress and nutrition surveys. Enzyme-linked immunosorbent assays determined highly signifcant diferences between apocrine-dominant sweat (AP), saliva before exercise (SBE), and saliva after exercise (SAE) cortisol …

Interview With Mary Zinkin, Mary Zinkin, Stephanie Vallance

Conflict Resolution Oral Histories

Mary Zinkin was interviewed by Stephanie Vallance on May 6, 2020. Also participating in the interview were Liza Schade and Lady J.

In this interview, Zinkin describes her own self-designed interdisciplinary graduate degrees in Conflict Resolution at Portland State and her influence in the creation of those degree programs at PSU. She discusses her academic work in the field of conflict mediation, and her view of the need for a professional, skills-based degree that blended theory and practice. She describes the logistics of getting the program off the ground, noting the development of curriculum, number of students, and the conversation …

A Rapid, Simple, Inexpensive, And Mobile Colorimetric Assay Covid-19-Lamp For Mass On-Site Screening Of Covid-19, Franklin Wang Ngai Chow, Tony Tat Yin Chan, Anthony Raymond Tam, Suhui Zhao, Weiming Yao, Joshua Fung, Flora Ka Kei Cheng, George Chi Shing Lo, Stella Chu, Kam Leng Aw-Yong, James Yat Man Tang, Chi Ching Tsang, Hayes Kam Hei Luk, Antonio Cheuk Pui Wong, Kenneth Sze Ming Li, Longchao Zhu, Zirong He, Emily Wan Ting Tam, Tom Wai Hin Chung, Sally Cheuk Ying Wong, Tak Lun Que, Kitty Sau Chun Fung, David Christopher Lung, Alan Ka Lun Wu, Ivan Fan Ngai Hung, Patrick Chiu Yat Woo, Susanna Kar Pui Lau

Faculty of Science & Technology (THEi)

To control the COVID-19 pandemic and prevent its resurgence in areas preparing for a return of economic activities, a method for a rapid, simple, and inexpensive point-of-care diagnosis and mass screening is urgently needed. We developed and evaluated a one-step colorimetric reverse-transcriptional loop-mediated isothermal amplification assay (COVID-19-LAMP) for detection of SARS-CoV-2, using SARS-CoV-2 isolate and respiratory samples from patients with COVID-19 (n = 223) and other respiratory virus infections (n = 143). The assay involves simple equipment and techniques and low cost, without the need for expensive qPCR machines, and the result, indicated by color change, is easily interpreted by …

Dna Origami: A Nanodevice With Mega Potential, Aaron M. Dolich

The Synapse: Intercollegiate science magazine

No abstract provided.

Opening Large-Conductance Potassium Channels Selectively Induced Cell Death Of Triple-Negative Breast Cancer, Gina Sizemore, Sarah Mclaughlin, Mackenzie Newman, Kathleen Brundage, Amanda Ammer, Karen Martin, Elena Pugacheva, James Coad, Malcolm D. Mattes, Han-Gang Yu

Faculty & Staff Scholarship

Background

Unlike other breast cancer subtypes that may be treated with a variety of hormonal or targeted therapies, there is a need to identify new, effective targets for triple-negative breast cancer (TNBC). It has recently been recognized that membrane potential is depolarized in breast cancer cells. The primary objective of the study is to explore whether hyperpolarization induced by opening potassium channels may provide a new strategy for treatment of TNBC.

Methods

Breast cancer datasets in cBioPortal for cancer genomics was used to search for ion channel gene expression. Immunoblots and immunohistochemistry were used for protein expression in culture cells …

The Effects Of A Pathogenic Mutation And A Binding Partner On The Activity Of Polycystin Ion Channels, Haroon Alam Chaudhry

Theses and Dissertations

Mutations within polycystin-1 (PC1) and transcient receptor potential polycystin channel 2 (TRPP2) are the leading causes for development of the most common kidney disease, Autosomal Dominant Polycystic Kidney Disease (ADPKD). Although significant efforts have been made to investigate properties and characteristics of these proteins over the last three decades, their roles in ADPKD and how mutations in these proteins lead to cystogenesis is still largely unknown. In the current work, I have studied a novel TRPP2 mutation found in a patient family diagnosed with ADPKD that removes the stop codon and results in adding an additional twelve amino acids on …

Effectiveness And Mechanisms Of Change Of Mindfulness And Relaxation Training Delivered In A High School, Lana Tenaglia

Theses and Dissertations

This study addresses the lack of research on the effectiveness of two major treatments for an adolescent sample. Both mindfulness and relaxation training are two major interventions that can be utilized to improve symptomology for aggression, disruptive behavior, anxiety, depression, perceived stress, as well as for the improvement of self-concept and academic performance. The focus of this study is to compare the effectiveness of mindfulness and relaxation training in a non-clinical sample of adolescents. It was hypothesized that the participants in the mindfulness group would have greater decreased levels in all facets assigned with the exception of self-concept and academic …

Does Inhibitory Control And Emotion Regulation Alter The Degree To Which Aggressogenic Thought Is Expressed?, Jessica Lindsey Held

Theses and Dissertations

The effects of emotion dysregulation and inhibitory control on aggressogenic thought-behavior associations were investigated among 362 fifth- and sixth-grade boys (n = 195) and girls (n = 167) on Long Island, New York. Other-reported anger dysregulation and inhibitory control significantly qualified the relationship between all three cognitions (hostile attributions of intent, revenge goals in both ambiguous and unambiguous situations, and self-efficacy) and aggression. However, our predicted pattern for these 3-way interaction was supported only when the cognition involved self-efficacy—self-efficacy for aggression was most strongly associated with aggressive behavior under high levels of anger dysregulation and low levels of inhibitory control. …

Characterization Of A Speciese Adenovirus Vector As A Zika Virus Vaccine, Brianna L. Bullard, Brigette N. Corder, David N. Gordon, Theodore C. Pierson, Eric A. Weaver

Nebraska Center for Virology: Faculty Publications

The development of a safe and efficacious Zika virus (ZIKV) vaccine remains a global health priority. In our previous work, we developed an Adenovirus vectored ZIKV vaccine using a low-seroprevalent human Adenovirus type 4 (Ad4-prM-E) and compared it to an Ad5 vector (Ad5-prM-E). We found that vaccination with Ad4-prM-E leads to the development of a strong anti-ZIKV T-cell response without eliciting significant anti-ZIKV antibodies, while vaccination with Ad5-prM-E leads to the development of both anti-ZIKV antibody and T-cell responses in C57BL/6 mice. However, both vectors conferred protection against ZIKV infection in a lethal challenge model. Here we continued to characterize …

One-To-One Ipad Technology: Perceptions Versus Practice, Christopher Pipala

Theses and Dissertations

This study sought to determine how iPads were used for instruction in the secondary schools of a suburban school district as well as determine if a relationship existed between teacher beliefs about technology and the potential level of transformative integration of the devices in classroom instruction. The Technological Pedagogical Content Knowledge (TPACK) and Substitution, Augmentation, Modification, and Redefinition (SAMR) models comprised the theoretical framework for this study to facilitate discussion about the level of instructional transformation that resulted from the use of iPad technology.

This study utilized the Technology Uses and Perceptions Survey (TUPS) and Technology Integration Matrix Reflection (TIM-R) …