Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2020

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 10051 - 10080 of 32302

Full-Text Articles in Entire DC Network

A Preliminary Study Of The Diurnal Dynamics Of Photosynthetic Rate Of Three Grasses, Ming Ma, Z. L. Wang, Q. Z. Sun Jul 2020

A Preliminary Study Of The Diurnal Dynamics Of Photosynthetic Rate Of Three Grasses, Ming Ma, Z. L. Wang, Q. Z. Sun

IGC Proceedings (1977-2023)

No abstract provided.

Go to article

The Trend Of Drug Abuse In Taiwan During The Years 1999 To 2011, S.-F. Lee, J. Hsu, W.-I. Tsay Jul 2020

The Trend Of Drug Abuse In Taiwan During The Years 1999 To 2011, S.-F. Lee, J. Hsu, W.-I. Tsay

Journal of Food and Drug Analysis

Drug abuse has become one of the major public health issues in the world. In this study, we surveyed the laboratory analytical data of urine and non-urine cases collected through the Analytic Laboratory Drug Abuse Report System (ALDARS) and estimated the illicit drug use trends in Taiwan from 1999 to 2011. These samples were collected from suspects who were arrested for possessing and/or taking illicit drugs. Descriptive statistics were used to report the distribution rate and patterns of drug abuse. In addition, linear regression was applied to determine the trends of drug abuse. The results showed that methamphetamine was the …

Go to article

Internal Transcribed Spacer Sequence-Based Identification And Phylogenic Relationship Of I-Tiao-Gung Originating From Flemingia And Glycine (Leguminosae) In Taiwan, C.-T. Wu, C.-C. Hsieh, W.-C. Lin, C.-Y. Tang, C.-H. Yang, Y.-C. Huang, Y.-J. Ko Jul 2020

Internal Transcribed Spacer Sequence-Based Identification And Phylogenic Relationship Of I-Tiao-Gung Originating From Flemingia And Glycine (Leguminosae) In Taiwan, C.-T. Wu, C.-C. Hsieh, W.-C. Lin, C.-Y. Tang, C.-H. Yang, Y.-C. Huang, Y.-J. Ko

Journal of Food and Drug Analysis

Botanical root of Flemingia and Glycine of Leguminosae is used as a traditional Chinese medicine material "I-Tiao-Gung" in Taiwan. It is widely used in both traditional Chinese medicine and folk remedies for the treatment of rheumatism, arthropathy, leukorrhea, menalgia, menopausal syndrome, and chronic nephritis, and the improvement of bone mineral density. The quasi root of Glycine tomentella and Glycine tabacina is substituted and used by some off-shore island users, and it is also known as I-Tiao-Gung. Thus, the establishment of an effective method to distinguish the herb from alternative species is a critical issue. In this study, internal transcribed spacer …

Go to article

Direct Quantitative Analysis Of Benzodiazepines, Metabolites, And Analogs In Diluted Human Urine By Rapid Resolution Liquid Chromatography-Tandem Mass Spectrometry, R.-Y. Hsu, S.-A. Chan, S.-L. Lin, T.-Y. Lin, W.-L. Chu, M.-R. Fuh Jul 2020

Direct Quantitative Analysis Of Benzodiazepines, Metabolites, And Analogs In Diluted Human Urine By Rapid Resolution Liquid Chromatography-Tandem Mass Spectrometry, R.-Y. Hsu, S.-A. Chan, S.-L. Lin, T.-Y. Lin, W.-L. Chu, M.-R. Fuh

Journal of Food and Drug Analysis

Rapid resolution liquid chromatography (RRLC) coupled with triple quadrupole mass spectrometry (QqQ-MS) was developed for direct quantitative analysis of benzodiazepines (BDZs) and their metabolites, as well as BDZ analogs (zopiclone, zolpidem, and zaleplon) in diluted human urine. A perfluorophenyl column packed with sub-2-mm particles and a C8 precolumn were applied to accomplish RRLC analysis with symmetric peak shapes. Urine samples were diluted 10-fold with Milli-Q water prior to autoinjection for direct quantification of 34 target analytes with negligible matrix effect. Gradient elution and dynamic multiple reaction monitoring were used for simultaneous quantitation of 34 BDZs, metabolites, and BDZ analogs. Good …

Go to article

Treatment Of Methamphetamine Abuse: An Antibody-Based Immunotherapy Approach, Y.-H. Chen, K.-L. Wu, H.-M. Tsai, C.-H. Chen Jul 2020

Treatment Of Methamphetamine Abuse: An Antibody-Based Immunotherapy Approach, Y.-H. Chen, K.-L. Wu, H.-M. Tsai, C.-H. Chen

Journal of Food and Drug Analysis

Methamphetamine is a highly addictive psychostimulant with tens of millions of abusers around the world. There is no effective or approved medication for treating an addiction to it. Monoclonal antibodies with a high affinity for methamphetamine have the potential to sequester the drug in the vascular compartment and reduce entry into the brain, thereby acting as peripheral pharmacokinetic antagonists without inducing adverse effects on neurons. However, to maintain the antibodies at an effective level, repeated administration is required, which would be expensive and problematic for patient compliance. In this study, we intended to investigate whether using a recombinant adeno-associated virusmediated …

Go to article

Potential Therapeutic Strategy To Treat Substance Abuse Related Disorders, S.L. Chang Jul 2020

Potential Therapeutic Strategy To Treat Substance Abuse Related Disorders, S.L. Chang

Journal of Food and Drug Analysis

The "Potential therapeutic strategy to treat substance-abuse-related disorders" session was chaired by Dr. Sulie L. Chang, director of NeuroImmune Phamacology at Seton Hall University. The four presenters were: Dr Wenzhe Ho (Miniway to stop HIV/HCV), Dr Ru-Band Lu (Low dose of memantine in the treatment of opioid dependence in human), Dr Ping Zhang (Treatment of alcohol-related disorders: Learning from stem/progenitor cells), and Dr Yun-Hsiang Chen (Treatment of methamphetamine abuse: An antibody-based immunotherapy approach). Copyright © 2013, Food and Drug Administration, Taiwan.

Go to article

Genomics And Personalized Medicine: Chrna5- Chrna3-Chrnb4 And Smoking Cessation Treatment, L.-S. Chen, L.J. Bierut Jul 2020

Genomics And Personalized Medicine: Chrna5- Chrna3-Chrnb4 And Smoking Cessation Treatment, L.-S. Chen, L.J. Bierut

Journal of Food and Drug Analysis

Cigarette smoking is highly addictive, and modern genetic research has identified robust genetic influences on nicotine dependence. An important step in translating these genetic findings is to identify the genetic factors affecting smoking cessation in order to enhance current smoking cessation treatments. We review the significance of variants in the nicotinic receptor gene cluster (CHRNA5eCHRNA3eCHRNB4) in the prediction of smoking quantity, smoking cessation, and response to cessation medication in multiple studies of smoking cessation. Three common haplotypes (low-risk, intermediate-risk, and high-risk) in the CHRNA5eCHRNA3eCHRNB4 region are defined by rs16969968 and rs680244. The genetic variants in the CHRNA5eCHRNA3eCHRNB4 region that predict …

Go to article

Substance Use Disorders And Hiv In Vietnam Since Doi Moi (Renovation): An Overview, L.M. Giang, L.B. Ngoc, V.H. Hoang, K. Mulvey, R.A. Rawson Jul 2020

Substance Use Disorders And Hiv In Vietnam Since Doi Moi (Renovation): An Overview, L.M. Giang, L.B. Ngoc, V.H. Hoang, K. Mulvey, R.A. Rawson

Journal of Food and Drug Analysis

Drawing frompublished and gray literature, this manuscript focuses on the following topics: (1) changing patterns of substance use and abuse in Vietnamsince the early 1990s; (2) the roles of substance use in the human immunodeficiency virus (HIV) epidemic; (3) the responses of theVietnamese government and other entities (both domestic and international) to substance use disorders (SUDs) and HIV; and (4) the current research capacity in Vietnam and ways in which furthering research in Vietnam could enrich our knowledge of the linkages between SUDsandHIVand of effectivemeasures to reduce theirpublichealth consequences.Agrowing number of studies during the past 2 decades show dynamic and …

Go to article

Collaborative Addiction Research In The United States And Asia, G. Bart Jul 2020

Collaborative Addiction Research In The United States And Asia, G. Bart

Journal of Food and Drug Analysis

Comparisons between Asian American and Pacific Islander (AAPI) and, when possible, similar populations from their ancestral land of origin may allow for unique insights into the development of substance use disorders. Drawn from research conducted within the Hmong residing in the United States of America (USA) and from ongoing collaborative work between the USA and Vietnam, this paper presents a few examples of the types of addiction research that may be possible in Asian populations, both in the USA and in Asia, with a focus on developing South East Asian countries and their AAPI counterparts in the USA. Approaches to …

Go to article

Current Research On The Epidemiology, Medical And Psychiatric Effects, And Treatment Of Methamphetamine Use, R.A. Rawson Jul 2020

Current Research On The Epidemiology, Medical And Psychiatric Effects, And Treatment Of Methamphetamine Use, R.A. Rawson

Journal of Food and Drug Analysis

Methamphetamine (MA) is a drug that is widely used in many parts of the world. It has multiple neurobiological impacts on the nervous system; some of which are transitory and some longer lasting. MA activates the reward system of the brain and produces effects that are highly reinforcing, which can lead to abuse and dependence. Routes of administration that produce rapid onset of the drug effects (i.e., smoking and injection) are likely to lead to more rapid addiction and more medical and psychiatric effects. The medical effects of MA use are extensive, and chronic use of MA can produce significant …

Go to article

Substance Abuse And The Hiv Situation In Malaysia, D. Singh, M.C. Chawarski, R. Schottenfeld, B. Vicknasingam Jul 2020

Substance Abuse And The Hiv Situation In Malaysia, D. Singh, M.C. Chawarski, R. Schottenfeld, B. Vicknasingam

Journal of Food and Drug Analysis

Heroin continues to be the main drug used in Malaysia, whereas amphetamine-type stimulants (ATSs, such as ecstasy, syabu, and yaba) have been recently identified as a growing problem. A cumulative total of 300,241 drug users were detected between 1988 and 2006. It is also estimated that Malaysia has 170,000 injecting drug users. Human immunodeficiency virus (HIV) prevalence among drug users in the country ranges from 25% to 45%. Currently, there are approximately 380 general medical practice offices that offer agonist maintenance treatments for approximately 10,000 patients. There are 27,756 active patients in 333 general medical practice offices and government-run methadone …

Go to article

Hiv Treatment As Prevention: The Key To An Aids-Free Generation, M.W. Hull, J.S.G. Montaner Jul 2020

Hiv Treatment As Prevention: The Key To An Aids-Free Generation, M.W. Hull, J.S.G. Montaner

Journal of Food and Drug Analysis

The presence of elevated human immunodeficiency virus (HIV) viral load within blood and genital secretions is a critical driver of transmission events. Long-term suppression of the viral load to undetectable levels through the use of antiretroviral therapy is standard practice for the clinical management of HIV. Antiretroviral therapy therefore can play a key role in curbing HIV transmission. The results of a randomized clinical trial and several observational studies have now confirmed that antiretroviral therapy markedly decreases the risk of HIV transmission. Mathematical models and population-based ecologic studies suggest that further expansion of antiretroviral coverage within current guidelines can play …

Go to article

Pharmacogenomics Study In A Taiwanese Methadone Maintenance Cohort, S.-C. Wang, H.-H. Tsou, I.-K. Ho, K.-M. Lin, Y.-L. Liu Jul 2020

Pharmacogenomics Study In A Taiwanese Methadone Maintenance Cohort, S.-C. Wang, H.-H. Tsou, I.-K. Ho, K.-M. Lin, Y.-L. Liu

Journal of Food and Drug Analysis

Pharmacogenomics is the study of drug treatment responses in subgroups of patients on the basis of their genetic variants or genetic expression information. In 2006, the government of Taiwan launched a methadone maintenance treatment program, which is usually prescribed for patients with heroin dependence. In this study, 366 patients who had taken methadone continually in the previous 7 days were examined. Data from the Treatment Outcomes Profile (TOP), Severity of Dependence Scale (SDS), Clinical Opioid Withdrawal Scale (COWS), and Treatment Emergent Symptoms Scale (TESS) were obtained from the patients' report records. The genes CYP2B6, CYP3A4, and CYP2C19dwhich encode the liver …

Go to article

Studies On The Extraction Of Pumpkin Components And Their Biological Effects On Blood Glucose Of Diabetic Mice, H. Jin, Y.-J. Zhang, J.-X. Jiang, L.-Y. Zhu, P. Chen, J. Li, H.-Y. Yao Jul 2020

Studies On The Extraction Of Pumpkin Components And Their Biological Effects On Blood Glucose Of Diabetic Mice, H. Jin, Y.-J. Zhang, J.-X. Jiang, L.-Y. Zhu, P. Chen, J. Li, H.-Y. Yao

Journal of Food and Drug Analysis

Pumpkin crude extract (PCE) was extracted from pumpkin powder with water and 95% ethanol at 60°C. Several components were isolated and further purified by solvents purification and dialysis as well as column chromatography. The anti-diabetic activities of the hypoglycemic components extracted from pumpkin were identified using diabetic model mice which were induced by alloxan intraperitoneal injection. The diabetic mice were treated with pumpkin extracts by intraperitoneal injection at dosages of 100, 200 and 400 mg/kg body weight. Blood samples for glucose assays were taken from the diabetic mice before injection and 4, 7 and 11 hours after injection. The results …

Go to article

Determination Of Gemfibrozil In Drug Matrix And Human Biological Fluid By Dispersive Liquid-Liquid Microextraction With High Performance Liquid Chromatography, Panahi H. Ahmad, A. Feizbakhsh, M. Karimpour, E. Moniri Jul 2020

Determination Of Gemfibrozil In Drug Matrix And Human Biological Fluid By Dispersive Liquid-Liquid Microextraction With High Performance Liquid Chromatography, Panahi H. Ahmad, A. Feizbakhsh, M. Karimpour, E. Moniri

Journal of Food and Drug Analysis

A simple and rapid dispersive liquid-liquid microextraction technique coupled with high performance liquid chromatography (HPLC) was developed for the extraction and analysis of gemfibrozil in drug matrix and biological fluids like human plasma and urine samples. In this method, carbon tetrachloride at microliter volume level and methanol were used as extraction and disperser solvents, respectively. The effects of factors including the type and volume of disperser and extraction solvents, pH and extraction time on the performance of the sample preparation were carefully evaluated. Under optimum conditions, the obtained enrichment factors were between 9.2-9.3 and extraction recoveries were high and ranged …

Go to article

Physiochemical, Clarification, And Antioxidant Properties Of Aqueous Extract Of Xiao-Chai-Hu-Tang As Affected By Membrane Process, Z.-R. Yu, M.-S. Lin, Y.-M. Weng, B.-J. Wang Jul 2020

Physiochemical, Clarification, And Antioxidant Properties Of Aqueous Extract Of Xiao-Chai-Hu-Tang As Affected By Membrane Process, Z.-R. Yu, M.-S. Lin, Y.-M. Weng, B.-J. Wang

Journal of Food and Drug Analysis

Xiao-chai-hu-tang (XCHT) is a traditional Chinese herbal medicine which has been demonstrated to exhibit antioxidant and hepatoprotective functions. To reduce the unpleasant dark brown color and precipitates during storage, the performances of membrane process on the clarification and antioxidant capability of XCHT was evaluated. A membrane system equipped with either a microfiltration membrane (0.45 μm) or one of four ultrafiltration membranes (UK 200, UK 50, UP 20 and UK 10) was used. Our results indicated that less total solid was filtered through the membranes and thus a higher degree of clarification degree was achieved in permeates. Higher concentrations of active …

Go to article

Investigation Of The Nitrate And Nitrite Contents In Milk And Milk Powder In Taiwan, T.S. Yeh, S.F. Liao, C.Y. Kuo, W.I. Hwang Jul 2020

Investigation Of The Nitrate And Nitrite Contents In Milk And Milk Powder In Taiwan, T.S. Yeh, S.F. Liao, C.Y. Kuo, W.I. Hwang

Journal of Food and Drug Analysis

Cow milk is one of the most important nutrition sources besides breast milk for infants and babies; therefore the detection of nitrate and nitrite in milk is of great importance to the health of infants and babies. Traditional colorimetric method for the determination of the nitrate and nitrite concentrations in food is very tedious. In the present study, 100 samples of milk and milk powder were analyzed by ion chromatography to detect nitrate and nitrite simultaneously without tedious preparation steps. The limit of detection (LOD) for nitrate is 0.33 ppm and the LOD for nitrite 0.07 ppm. The measured nitrate …

Go to article

Resveratrol: An Active Natural Compound In Red Wines For Health, G. Murtaza, U. Latif, M. Najam-Ul-Haq, A. Sajjad, S. Karim, M. Akhtar, I. Hussain Jul 2020

Resveratrol: An Active Natural Compound In Red Wines For Health, G. Murtaza, U. Latif, M. Najam-Ul-Haq, A. Sajjad, S. Karim, M. Akhtar, I. Hussain

Journal of Food and Drug Analysis

Phytochemicals found in food have revealed noteworthy roles in treating and managing a large number of human diseases. The structure, source, bioavailability, pharmacokinetics and anti-cancer activity of resveratrol, a bioactive compound present mainly in red wine, are reviewed in this article. Resveratrol, a polyphenol, is a stilbene-type aromatic phytoalexin, which is principally found in red grapes. Numerous physiological activities like antioxidant, anticancer and antiaging activities of resveratrol have been elaborated in vitro, in investigational animal models and in human subjects. Studies in humans are still in the preliminary phases and thus, more investigations are required. The anticancer activity of resveratrol …

Go to article

Development Of Timely Controlled-Release Systems For Chronotherapy Of Propranolol With Minimization Of The Ph Effect In The Simulated Gastrointestinal Medium, L.-W. Lee, S.-F. Hung, H.-L. Lin, H.-O. Ho, M.-T. Sheu Jul 2020

Development Of Timely Controlled-Release Systems For Chronotherapy Of Propranolol With Minimization Of The Ph Effect In The Simulated Gastrointestinal Medium, L.-W. Lee, S.-F. Hung, H.-L. Lin, H.-O. Ho, M.-T. Sheu

Journal of Food and Drug Analysis

A timely controlled release dosage form with minimization of transit time and pH effects of gastrointestinal tract for chronotherapy of propranolol was developed. Ethylcellulose (EC) and Eudragit RS selected as the controlling membrane for drug-layering non-pareil seeds (NP) or extrusion-spheronized pellets incorporated with matrix materials or osmogents were characterized in the simulated gastric fluid (SGF) and pH change medium. Results demonstrated that when propranolol was layered on NP, Eudragit RS plasticized with 30% triethylcitrate (TEC) coated at 15% level could adjust a lag time close to the reference but with a slower release rate after then, while EC plasticized with …

Go to article

Pharmacokinetics Of Betamethasone Disodium Phosphate-Loaded Microparticle Following Pulmonary Delivery, W.-S. Cheng, J.-L. Chen, C.-H. Chiang Jul 2020

Pharmacokinetics Of Betamethasone Disodium Phosphate-Loaded Microparticle Following Pulmonary Delivery, W.-S. Cheng, J.-L. Chen, C.-H. Chiang

Journal of Food and Drug Analysis

Betamethasone (BTM) is a therapeutic agent for the treatment of pulmonary diseases. Betamethasone disodium phosphate (BDP) is a prodrug of BTM and is rapidly converted into BTM after dosing. In this study, intratracheal administration of the dry powder (ITp) of BDP-chitosan microparticle (BDP-CM) was investigated to determine the drug absorption and disposition in New Zealand white rabbits. In addition, intravenous injection (IV) and intratracheal instillation (ITs) of BDP solution were also investigated. The investigated 10% drug-loaded BDP-CM had a narrow size distribution (2.76 ± 0.25 μm), positive zeta potential (40.23 ± 1.98 mV) and low tap density (0.257 ± 0.106 …

Go to article

Chiral Separation Of Non-Nucleoside Reverse Transcription Inhibitor Efavirenz By Hplc On Cellulose-Based Chiral Stationary Phase, S.S. Pujeri, A.M.A. Khader, J. Seetharamappa Jul 2020

Chiral Separation Of Non-Nucleoside Reverse Transcription Inhibitor Efavirenz By Hplc On Cellulose-Based Chiral Stationary Phase, S.S. Pujeri, A.M.A. Khader, J. Seetharamappa

Journal of Food and Drug Analysis

A stereospecific HPLC method for the separation of efavirenz (EFZ) enantiomers in bulk drug and formulations was developed and validated on a normal-phase cellulose derivatized chiral column. The effect of organic modifiers, namely, 2-propanol, ethanol and trifluoroacetic acid in mobile phase was optimized to obtain the best enantiomeric separation. The retention times of (R)-EFZ and (S)-EFZ were observed to be 7.5 and 9.2 min, respectively. The calibration curve was found to be linear over the concentration range of 200-6210 ng/mL with a determination coefficient (R2) of 0.9999 for the (R)-isomer. The limit of detection (LOD) and limit of quantification (LOQ) …

Go to article

Chemical Fingerprint And Quantitative Analysis Of Cistanche Deserticola By Hplc-Dad-Esi-Ms, Z.-Y. Yang, D.-Y. Lu, S. Yao, R.-R. Zhang, Z.-J. Jiang, Z.-G. Ma Jul 2020

Chemical Fingerprint And Quantitative Analysis Of Cistanche Deserticola By Hplc-Dad-Esi-Ms, Z.-Y. Yang, D.-Y. Lu, S. Yao, R.-R. Zhang, Z.-J. Jiang, Z.-G. Ma

Journal of Food and Drug Analysis

An HPLC-DAD-ESI-MS method was employed for the chromatographic fingerprint analysis of Cistanche deserticola (Roucongrong in Chinese). Eleven batches of samples were analyzed to establish the reference fingerprint of C. deserticola. Eight peaks in the fingerprint of all the 11 batches of samples were assigned as "characteristic peaks", and identified by comparing their retention time and mass spectra with those of the reference substances. The similarity of the 11 batches of samples was evaluated by a simulative mean chromatogram. The results indicated that the samples from different origins shared similar HPLC fingerprints. In addition, an HPLC-DAD method was developed for simultaneous …

Go to article

Inhibition Of The Ethanolic Extract From Polygonum Cuspidatum Root On The Functions Epstein-Barr Virus Latent Membrane Protein 1, C.-Y. Yiu, S.-Y. Chen, Y.-P. Chen, T.-P. Lin Jul 2020

Inhibition Of The Ethanolic Extract From Polygonum Cuspidatum Root On The Functions Epstein-Barr Virus Latent Membrane Protein 1, C.-Y. Yiu, S.-Y. Chen, Y.-P. Chen, T.-P. Lin

Journal of Food and Drug Analysis

Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1), which is expressed during viral latency, has oncogenic properties that are associated with several malignant diseases. The purpose of this study is to examine how the ethanolic extract from Polygonum cuspidatum root (PcE) inhibits the functions of latent membrane protein 1. We found that the viability of EBV-positive cells, B95-8 cells decreased in a time- and dose-dependent manner after the cells were treated with PcE. Furthermore, PcE inhibited the transcription of the LMP1 gene, BNLF1. This was attributed to the inhibition of the expression of Rta, which are known to activate the …

Go to article

Fingerprint Analysis Of Ginkgo Biloba Extract And Ginkgo Semen In Preparations By Lc-Q-Tof/Ms, J.-L. Luo, F.-L. Lu, Y.-C. Liu, Y.-C. Shih, C.-F. Lo Jul 2020

Fingerprint Analysis Of Ginkgo Biloba Extract And Ginkgo Semen In Preparations By Lc-Q-Tof/Ms, J.-L. Luo, F.-L. Lu, Y.-C. Liu, Y.-C. Shih, C.-F. Lo

Journal of Food and Drug Analysis

An ultra-high performance liquid chromatography with tandem quadrupole/flight mass spectrometry (LC-Q-TOF/MS) method was developed for the chromatographic fingerprint analyses of Ginkgo biloba extract and Ginkgo semen. All samples were extracted with 70% methanol and part of each extract was hydrolyzed by acids. The chromatographic analyses of these materials were performed on a C18 analytical column (3.0 x 150 mm, 2.7 μm) with gradient elution using methanol and water with 0.01% formic acid at a flow rate of 0.5 mL/min. Mass spectrometry was performed in the negative-ion mode ESI to determine the compounds in G. biloba extract and G. semen by …

Go to article

Total Nutritional Capacity And Inflammation Inhibition Effect Of Acalypha Alnifolia Klein Ex Wild - An Unexplored Wild Leafy Vegetable, R. Ponnusamy, P. Thangaraj Jul 2020

Total Nutritional Capacity And Inflammation Inhibition Effect Of Acalypha Alnifolia Klein Ex Wild - An Unexplored Wild Leafy Vegetable, R. Ponnusamy, P. Thangaraj

Journal of Food and Drug Analysis

Investigation of the nutritional as well as trace elements of a wild leafy vegetable, Acalypha alnifolia, and evaluation of the analgesic, anti-inflammatory, and antipyretic properties of acetone and methanol leaf extracts are the main objectives of the present study. The powdered A. alnifolia leaf sample was subjected to nutritional and mineral analysis. Plant leaves were extracted (using the Soxhlet apparatus) as successive solvent extractions. The extract doses of 200 and 400 mg/kg of acetone and methanol extracts were used for pharmacology study. The analgesic, anti-inflammatory, and antipyretic experiments were carried out by using animal models. The obtained result proves that …

Go to article

Application Of Ion Mobility Spectrometry For The Determination Of Tramadol In Biological Samples, A. Sheibani, N. Haghpazir Jul 2020

Application Of Ion Mobility Spectrometry For The Determination Of Tramadol In Biological Samples, A. Sheibani, N. Haghpazir

Journal of Food and Drug Analysis

In this study, a simple and rapid ion mobility spectrometry (IMS) method has been described for the determination of tramadol. The operating instrumental parameters that could influence IMS were investigated and optimized (temperature; injection: 220 and IMS cell: 190°C, flow rate; carrier: 300 and drift: 600 mL/minute, voltage; corona: 2300 and drift: 7000 V, pulse width: 100 μs). Under optimum conditions, the calibration curves were linear within two orders of magnitude with R2 ≥ 0.998 for the determination of tramadol in human plasma, saliva, serum, and urine samples. The limits of detection and the limits of quantitation were between 0.1 …

Go to article

Regulation Of Human Cytokines By Cordyceps Militaris, Y. Sun, Y. Shao, Z. Zhang, L. Wang, A.M. Mariga, G. Pang, C. Geng, C.-T. Ho, Q. Hu, L. Zhao Jul 2020

Regulation Of Human Cytokines By Cordyceps Militaris, Y. Sun, Y. Shao, Z. Zhang, L. Wang, A.M. Mariga, G. Pang, C. Geng, C.-T. Ho, Q. Hu, L. Zhao

Journal of Food and Drug Analysis

Cordyceps (Cordyceps militaris) exhibits many biological activities including antioxidant, inhibition of inflammation, cancer prevention, hypoglycemic, and antiaging properties, etc. However, a majority of studies involving C. militaris have focused only on in vitro and animal models, and there is a lack of direct translation and application of study results to clinical practice (e.g., health benefits). In this study, we investigated the regulatory effects of C. militaris micron powder (3 doses) on the human immune system. The study results showed that administration of C. militaris at various dosages reduced the activity of cytokines such as eotaxin, fibroblast growth factor-2, GRO, and …

Go to article

Electrochemical Oxidation Behavior Of Hydrochlorothiazide On A Glassy Carbon Electrode And Its Voltammetric Determination In Pharmaceutical Formulations And Biological Fluids, A.F. Alghamdi Jul 2020

Electrochemical Oxidation Behavior Of Hydrochlorothiazide On A Glassy Carbon Electrode And Its Voltammetric Determination In Pharmaceutical Formulations And Biological Fluids, A.F. Alghamdi

Journal of Food and Drug Analysis

The electrochemical oxidation behavior of hydrochlorothiazide (HCT) on a glassy carbon as a working electrode was investigated in Britton-Robinson (B-R) buffer pH 3, by using anodic stripping voltammetry (ASV) and cyclic voltammetry (CV). This drug gave a well-defined voltammetric oxidation peak at + 1200 mV versus an Ag/AgCl reference electrode. The electrochemical oxidation process was shown to be irreversible and diffusion controlled, with adsorption characterized over the entire pH range. The optimized conditions, such as accumulation time and potential, scan rate, frequency, pulse amplitude, varying of working electrodes, and instrumental parameters were studied. The calibration graph for HCT was obtained …

Go to article

The Implementation Of Haccp Management System In A Chocolate Ice Cream Plant, J. Lu, X.-H. Pua, C.-T. Liu, C.-L. Chang, K.-C. Cheng Jul 2020

The Implementation Of Haccp Management System In A Chocolate Ice Cream Plant, J. Lu, X.-H. Pua, C.-T. Liu, C.-L. Chang, K.-C. Cheng

Journal of Food and Drug Analysis

To guarantee the safety of chocolate ice cream production, the Hazard Analysis Critical Control Points (HACCP) system was applied to the production process. The biological, chemical, and physical hazards that may exist in every step of chocolate ice cream production were identified. In addition, the critical control points were selected and the critical limits, monitoring, corrective measures, records, and verifications were established. The critical control points, which include pasteurization and freezing, were identified. Implementing the HACCP system in food manufacturing can effectively ensure food safety and quality, expand the market, and improve the manufacturers' management level. © 2013, Food and …

Go to article

Facile Method For Determination Of Deoxycytidine Kinase Activity In Biological Milieus, W.-H. Hao, L.-C. Yang, J.-J. Wang, C.-S. Hsu, L.-C. Chang, K.-Y. Hsu Jul 2020

Facile Method For Determination Of Deoxycytidine Kinase Activity In Biological Milieus, W.-H. Hao, L.-C. Yang, J.-J. Wang, C.-S. Hsu, L.-C. Chang, K.-Y. Hsu

Journal of Food and Drug Analysis

A new analytical method for determining deoxycytidine kinase (dCK) activity in biological milieus using luminescence is reported here. This method, based on utilizing adenosine triphosphate (ATP) as the sole phosphate donor in the kinase reaction and monitoring ATP consumption via a luciferase-based chemiluminescence reaction, is capable of detecting dCK activity without the use of specific substrates or radioisotope techniques. Comparing with the reverse-phase high-performance liquid chromatography method, this new method is suggested to be efficient and sensitive. Further, application of the proposed method for profiling dCK activity in cultured cancer cells revealed that a cervix cell line exhibited the highest …

Go to article

First Prev Next Last