Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2020

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 3181 - 3210 of 10641

Full-Text Articles in Entire DC Network

Studies On Food Functionality And Safety In Japan - Evaluation By Genomics, A. Keiko Jul 2020

Studies On Food Functionality And Safety In Japan - Evaluation By Genomics, A. Keiko

Journal of Food and Drug Analysis

In Japan, research on functional foods had humble beginnings about 30 years ago. It traced a unique path of development to a mainstay of frontal food science. Meanwhile, nutrigenomics was launched as a comprehensive method for investigating total effects of nutrients in the body. This can be applied to functional foods as well as nutrients. However, the data analysis needs care. Since even functional foods contain a variety of compounds together with functional factors, the data inherently include noises to a certain extent. Thus, there are often the case that inappropriate choices of experimental designs and statistic data analyses lead …

Go to article

Interaction Of Tea Catechins With Phospholipids - Roles In Their Tastes And Biological Activities, T. Nakayama, T. Ishii, Y. Uekusa, K. Kato, S. Kumazawa Jul 2020

Interaction Of Tea Catechins With Phospholipids - Roles In Their Tastes And Biological Activities, T. Nakayama, T. Ishii, Y. Uekusa, K. Kato, S. Kumazawa

Journal of Food and Drug Analysis

Green tea is well known for its various physiological effects, but there are few studies relating the tastes of tea catechins to their biological activities. We have focused on the interaction of tea catechins with phospholipids to clarify the relationship. The galloyl-type catechins, epicatechin gallate (ECg) and epigallocatechin gallate (EGCg) usually show beneficial properties including chemopreventive, antimutagenic and antioxidant actions more potently than the nongalloyl-type catechins, epicatechin (EC) and epigallocatechin (EGC). The difference in their chemical structures is correlated with their affinity for phospholipid membranes and incorporated amounts into liposomes. This indicates that the interaction of the galloyl-type catechins with …

Go to article

New Analytical Advances For Addressing Healthful Constituents In Foods, J.N. Seiber Jul 2020

New Analytical Advances For Addressing Healthful Constituents In Foods, J.N. Seiber

Journal of Food and Drug Analysis

The tools available to analyze the chemical composition of foods and other complex samples have developed rapidly, including commercial introduction of new instruments and many examples of utility. Areas of application include identification and quantification of newly uncovered bioactive chemicals and chemical classes, adulteration and authentication of foods, determining bioavailability of both parent and metabolites of specific interest, and addressing emerging environmental contaminant issues. FT-infrared and other spectroscopic techniques have seen increasing applications particularly in the area of in situ and/or screening analyses for the presence of specific classes of chemicals. Many of these tools are based upon mass spectrometry, …

Go to article

Diet, Intestinal Microbiota And Health, Y.-K. Lee Jul 2020

Diet, Intestinal Microbiota And Health, Y.-K. Lee

Journal of Food and Drug Analysis

Dietary component has direct effect on the intestinal microbiota profile. Intestinal microbiota plays critical roles in the health and well being of the host. Dietary habit is largely cultural and geographical base. A better understanding of the interactions between dietary components, food matrix and the intestinal microbes, would pave way for correctly intervention to maintain our health and well being.

Go to article

Food Factors And Food Safety... A Perspective, V. Prakash Jul 2020

Food Factors And Food Safety... A Perspective, V. Prakash

Journal of Food and Drug Analysis

Food Factors that positively contributes to Food Safety is a major issue today across the World. Additives that are added to Processed Foods and other factors have to have an attachment of Quality and Safety aspect which has to be beyond the doubt of any consumer. The problem of safety does not stem only from the small amount of contamination that may occur but sometimes it also has a huge amount of responsibility in the Chain as it moves across from Rural to Urban with a clear pathway of its destination into Hyper markets especially when one looks at Nutraceuticals. …

Go to article

Effect Of Reconstituted Apple Juice With Alkaline Electrolyzed Water On Cell Proliferation And Apoptosis Of Ht-29 Cells, M. Kim, J. Fischer, Y.-C. Hung Jul 2020

Effect Of Reconstituted Apple Juice With Alkaline Electrolyzed Water On Cell Proliferation And Apoptosis Of Ht-29 Cells, M. Kim, J. Fischer, Y.-C. Hung

Journal of Food and Drug Analysis

Apple juice, known as a good antioxidant source, may partially protect the body from oxidative stress. In this report, the effect of apple juice reconstituted with alkaline electrolyzed water (EO-apple juice) on HT-29 cells was investigated. Specifically, the total antioxidant capacity (ORAC and TEAC) of EO-apple juice, and the effects this EO-apple juice on cell proliferation (MTT assay), DNA fragmentation, and oxidative DNA damage (comet assay) of HT-29 cells were evaluated. The TEAC value of EO-apple juice was higher (2773 μM TE vs. 1739 μM TE) than apple juice reconstituted with ultra pure water (Water-apple juice). EO-apple juice also had …

Go to article

Molecular Targets Of Dietary Phytochemicals For Human Chronic Diseases: Cancer, Obesity, And Alzheimer's Diseases, N.R. Song, K.W. Lee, H.J. Lee Jul 2020

Molecular Targets Of Dietary Phytochemicals For Human Chronic Diseases: Cancer, Obesity, And Alzheimer's Diseases, N.R. Song, K.W. Lee, H.J. Lee

Journal of Food and Drug Analysis

Naturally occurring dietary phytochemicals have been recognized as possessing many health-promoting effects. Recent studies suggest that inflammation is closely related to chronic disease, including cancer, atherosclerosis, neurodegeneration, obesity, diabetes, asthma, articular rheumatism, and skin-aging. Extracellular stimuli transmit signals into a cell by activating the target kinases involved in inflammation and the onset of chronic diseases. Phytochemicals can directly bind to specific proteins involved in intracellular signaling networks and regulate their activity, leading to diverse physiological effects. A better understanding of the direct interactions between phytochemicals and target proteins would contribute to development of nutritional strategies for preventing or delaying the …

Go to article

The Impact Of Food Components And Dietary Factors On Oral Health, C.D. Wu Jul 2020

The Impact Of Food Components And Dietary Factors On Oral Health, C.D. Wu

Journal of Food and Drug Analysis

This presentation provides an overview of the impact of food components and dietary factors on oral health. The protective properties of various foods, plant extracts and plant-based polyphenolic compounds on dental caries and periodontal disease are discussed. Laboratory, human, and epidemiological studies demonstrating the multiple mechanistic actions in supporting their contribution to oral health and disease prevention are summarized. The need and development of multidisciplinary research approach toward experimental designs and strategies in clinical and epidemiological studies are also emphasized.

Go to article

Tomato, Broccoli, Soy And Reduced Prostate Cancer Risk: Whole Foods Or Their Bioactive Components?, K. Zuniga, Jr. J.W. Erdman Jul 2020

Tomato, Broccoli, Soy And Reduced Prostate Cancer Risk: Whole Foods Or Their Bioactive Components?, K. Zuniga, Jr. J.W. Erdman

Journal of Food and Drug Analysis

Prostate cancer (PCa) is the second leading cause of cancer-related deaths in U.S. men. PCa is a slow-growing cancer; therefore, identifying dietary interventions to reduce the risk or progression of PCa could greatly impact public health. A growing body of evidence has identified several foods that may reduce the risk of PCa. Mechanistic studies have investigated individual bioactives from foods to identify their anticarcinogenic properties; however, it is also important to study the whole food. In rodent models of PCa, we have shown that consumption of whole tomato powder was more effective than lycopene alone in reducing PCa progression. In …

Go to article

Vitamin And Non-Vitamin Antioxidants And Their Interaction In Food, L.H. Skibsted Jul 2020

Vitamin And Non-Vitamin Antioxidants And Their Interaction In Food, L.H. Skibsted

Journal of Food and Drug Analysis

Aerobic life has been challenged by the changing conditions appearing through evolution resulting in appearance of both hydrophilic and lipophilic antioxidants as an indispensable protection against the ubiquitous reactive oxygen- and nitrogen species. Interaction between hydrophilic and lipophilic antioxidants at interfaces often results in synergistic effects important for food stability. Such concerted actions by antioxidants also seem of relevance for human nutrition, but need a more mechanistic description. Non-vitamin antioxidants like the hydrophilic polyphenols including their glycosides thus show synergism through enhancing the lipophilic tocopherols as chainbreaking antioxidants. While this tocopherol/polyphenol synergism seems to be controlled kinetically, the synergism between …

Go to article

Bioactive Compounds From By-Products Of Shrimp Processing Industry In Vietnam, T.S. Trung, P.T.D. Phuong Jul 2020

Bioactive Compounds From By-Products Of Shrimp Processing Industry In Vietnam, T.S. Trung, P.T.D. Phuong

Journal of Food and Drug Analysis

Shrimp heads from the shrimp processing industry in Vietnam can be a good source for production of bioactive compounds. It is estimated that there is an amount of 200,000 metric tons of shrimp by-products annually from two main species: black tiger shrimp (Penaeus monodon) and white shrimp (Penaeus vannamei). We found that the shrimp by-products can be used as raw materials for extraction of chitosan and lipid-mineral-rich carotenoprotein by combining chemical and biological treatment. Chitosan has been recognized as a multifunctional bioactive compound and has been used widely in food, biotechnology, cosmetics and medicine. Lipid-mineral-rich carotenoprotein can be used as …

Go to article

Functional Foods,,Naturalhealth Products And Nutrigenomics Research In Canada, C.L. Parr-Vásquez, R.Y. Yada Jul 2020

Functional Foods,,Naturalhealth Products And Nutrigenomics Research In Canada, C.L. Parr-Vásquez, R.Y. Yada

Journal of Food and Drug Analysis

The relationship between food consumption and health outcomes has become a priority research focus in Canada. This has driven an emerging interest in functional foods, natural health products and nutrigenomics. Capitalizing on its abundant natural resources, world class research expertise, renown facilities and collaborative research environment, Canadian researchers are developing innovative approaches to reduce the incidence of diseases such as hypertension, diabetes type II and cardiovascular disease. Canada boasts approximately 15 government research centres, 16 universities and colleges, 4 technology centres and 2 institutes actively carrying out research in the area of functional foods, natural health products and nutrigenomics. These …

Go to article

Mechanisms Underlying Food Functionality Via Molecular Chaperones: Chemical Training Hypothesis, A. Murakami, K. Ohnishi Jul 2020

Mechanisms Underlying Food Functionality Via Molecular Chaperones: Chemical Training Hypothesis, A. Murakami, K. Ohnishi

Journal of Food and Drug Analysis

Most physiologically functional food factors are derived from plants. Although those chemicals exhibit versatile bioactivities, their mechanisms of action are not fully understood. It is important to indicate that phytochemicals, but not plant nutrients, xenobiotics in humans and thus induce expressions of self-defense molecules, including anti-oxidative and xenobiotic function as metabolizing enzymes via the Keap1/Nrf2 system. In addition, recent reports have shown that several phytochemicals are capable of up-regulating the activities of molecular chaperones such as heat shock proteins (HSPs) and proteasomes. For example, sulforaphane, a sulfur-containing phytochemical present in cruciferous plants, was recently reported to induce HSP27 expression and …

Go to article

Developing Public Health Messages For Non-Essential Food Components, C.-H. Lu, Jr. J.W. Erdman Jul 2020

Developing Public Health Messages For Non-Essential Food Components, C.-H. Lu, Jr. J.W. Erdman

Journal of Food and Drug Analysis

Foods contain a variety of essential and non-essential components. Emerging evidence suggests that both the traditional essential and some non-essential portions of foods provide health benefits. For example, vitamin A and C must be provided in the diet to prevent deficiency diseases, but what about non-vitamin A producing carotenoids, polyphenols, isothiocyanates, allyl sulfides, etc.? The weight of experimental evidence suggests that these and other dietary bioactives contribute to healthfulness. Most countries have " quantitative" Recommended Dietary Allowances (RDAs) to help guide health professionals to avoid deficiency diseases in their populations. The United States has the Dietary Reference Intakes that includes …

Go to article

Journal Of Food And Drug Analysis: Preface, G.-C. Yen, L.S. Hwang Jul 2020

Journal Of Food And Drug Analysis: Preface, G.-C. Yen, L.S. Hwang

Journal of Food and Drug Analysis

[No abstract available]

Go to article

Targeting Inflammatory Pathways By Dietary Agents For Prevention And Therapy Of Cancer, B.B. Aggarwal, S. Prasad, V.R. Yadav, B. Park, J.H. Kim, S.C. Gupta, S.W. Yoon, A. Lavasanifar, B. Sung Jul 2020

Targeting Inflammatory Pathways By Dietary Agents For Prevention And Therapy Of Cancer, B.B. Aggarwal, S. Prasad, V.R. Yadav, B. Park, J.H. Kim, S.C. Gupta, S.W. Yoon, A. Lavasanifar, B. Sung

Journal of Food and Drug Analysis

Chronic infections, obesity, alcohol, tobacco, radiation, environmental pollutants, and high-calorie diet have been recognized as major risk factors for the most common types of cancers. All these risk factors are linked to cancer through inflammation. While acute inflammation that persists for short-term mediates host defense against infections, chronic inflammation that lasts for long-term can predispose the host to various chronic illnesses, including cancer. Linkage between cancer and inflammation is indicated by numerous lines of evidence; first, transcription factors NF-κ and STAT3, two major pathways for inflammation, are activated by most cancer risk factors; second, an inflammatory condition precedes most cancers; …

Go to article

Luteolin Overcomes Resistance To Benzyl Isothiocyanate-Induced Apoptosis In Human Colorectal Cancer Hct-116 Cells, R. Sakai, S. Yokobe, N. Abe, N. Miyoshi, Y. Murata, Y. Nakamura Jul 2020

Luteolin Overcomes Resistance To Benzyl Isothiocyanate-Induced Apoptosis In Human Colorectal Cancer Hct-116 Cells, R. Sakai, S. Yokobe, N. Abe, N. Miyoshi, Y. Murata, Y. Nakamura

Journal of Food and Drug Analysis

We have previously identified p53, a universal sensor of genotoxic stress, as a negative regulator of the apoptosis induction by benzyl isothiocyanate (BITC) in the normal colon fibroblastoid cells. In the present study, we further confirmed that BITC has a potential to induce cytotoxicity in the p53-mutated colon cancer HT-29 cells in preference to HCT-116 cells with wild-type p53. To obtain effective induction of BITC-stimulated apoptosis in p53-positive cells, we investigated the combination effect of BITC and food ingredient that may overcome resistance to BITC. Pretreatment with luteolin potentiated the cytotoxicity induction by BITC in HCT-116 cells but not in …

Go to article

Autophagy As A Target For Anticancer Therapy And Its Modulation By Phytochemicals, M.-K. Kim, D.H. Suh, J. Seoung, H.S. Kim, H.H. Chung, Y.-S. Song Jul 2020

Autophagy As A Target For Anticancer Therapy And Its Modulation By Phytochemicals, M.-K. Kim, D.H. Suh, J. Seoung, H.S. Kim, H.H. Chung, Y.-S. Song

Journal of Food and Drug Analysis

Autophagy is a catabolic process and has an important homeostatic role, mediating the removal of dysfunctional or superfluous proteins and organelles. Dysfunction of autophagy is involved in various physiologic and pathologic conditions, such as developmental cell death, clearance of pathogens, aging process, neurodegenerative diseases, and cancers. Cancer cells which are inherently vulnerable to metabolic stress and also defective in apoptosis are more dependent on autophagy for cell survival than normal cells. Autophagy might have a dual but conflicting role in carcinogenesis, tumor-suppressing and tumor-promoting role. The roles of autophagy in specific type cancers in vivo, however, have not been determined …

Go to article

From Basic Science To Dietary Guidance: Dietary Fiber As An Example, J.R. Lupton Jul 2020

From Basic Science To Dietary Guidance: Dietary Fiber As An Example, J.R. Lupton

Journal of Food and Drug Analysis

Although dietary fiber is a nonessential nutrient it has achieved the status of having nutrient intake values and dietary recommendations. How it achieved this may serve as a prototype for other nonessential functional food components. An important step was the development of a worldwide accepted definition and the analytical method consistent with that definition. A database of fiber values in foods facilitated important prospective cohort studies investigating the effect of fiber intake on decreased risk of key diseases. The strongest data relating dietary fiber to health involved its laxation effect, but due to high individual variability, laxation was not the …

Go to article

Anticancer Property Of Allyl Sulfides Derived From Garlic (Allium Sativum L.), T. Seki, T. Hosono, S. Suda, K. Kimura, T. Ariga Jul 2020

Anticancer Property Of Allyl Sulfides Derived From Garlic (Allium Sativum L.), T. Seki, T. Hosono, S. Suda, K. Kimura, T. Ariga

Journal of Food and Drug Analysis

Several lines of evidences imply that garlic (Allium sativum L.) is one of the potent vegetable for the cancer prevention. Fresh garlic extract, garlic powder, garlic oil, and organosulfur compounds derived from garlic have been reported to exhibit the anticancer effect through their anticarcinogenic, antimutagenic, and antitumor properties. Evidences from experimental studies, those which have been performed primarily at molecular basis with garlic are introduced in this review. Especially, we focused on allyl sulfides as promising compounds derived from garlic for cancer prevention, and discussed the anticancer properties of allyl sulfides in terms of anticarcinogenic, antimutagenic and antigenotoxic activity, induction …

Go to article

Cancer Prevention By Different Forms Of Tocopherols, C.S. Yang, G. Li, Z. Yang Jul 2020

Cancer Prevention By Different Forms Of Tocopherols, C.S. Yang, G. Li, Z. Yang

Journal of Food and Drug Analysis

Low vitamin E nutritional status has been suggested to increase cancer risk. However, recent large-scale human trials with high doses of alpha-tocopherol (α-T) have produced disappointing results. This points out the need for a better understanding of the biological activities of different forms of tocopherols. Using a tocopherol mixture that is rich in γ-T (γ-TmT), we demonstrated the inhibition of colon carcinogenesis in mice, and the inhibition is associated with decreased levels of 8-isoprostane, nitrotyrosine, prostaglandin E2 and leukotriene B4. Dietary 0.3% γ-TmT also inhibited chemically induced lung tumorigenesis in the A/J mice as well as the growth of lung …

Go to article

New Development Of Vitamin K Research: Identification Of Human Menaquinone-4 Biosynthetic Enzyme, K. Nakagawa Jul 2020

New Development Of Vitamin K Research: Identification Of Human Menaquinone-4 Biosynthetic Enzyme, K. Nakagawa

Journal of Food and Drug Analysis

Natural vitamin K is found in two forms: a plant form, phylloquinone (PK) and bacterial forms, menaquinones (MKs). In many species, including humans, PK is a minor constituent of hepatic vitamin K content, with most hepatic vitamin K content comprising long-chain MKs. Menaquinone-4 (MK-4) is ubiquitously present in extrahepatic tissues, with particularly high concentrations in the brain, kidney and pancreas of humans and rats. It has consistently been shown that PK is endogenously converted to MK-4. The molecular mechanisms for these conversion reactions have been unclear. To identify the MK-4 biosynthetic enzyme, we screened the human genome database for prenylation …

Go to article

Challenges In Health Risk Assessment Of Food Factors, D.P.H. Hsieh Jul 2020

Challenges In Health Risk Assessment Of Food Factors, D.P.H. Hsieh

Journal of Food and Drug Analysis

Food factors (FF) are nutrients and other related substances present in processed foods for special dietary uses related to health promotion and disease prevention. Due to the nutritional and other favorable effects of FF, their health risk assessment is more complex than the established food safety risk assessment (FSRA) that addresses excessive intakes of food additives and contaminants. For FF, risk assessment adds a new dimension to also address risks posed by inadequate intake of these food constituents, and is referred to as nutritional risk assessment (NRA). NRA consists of the four standard steps of FSRA: hazard identification, hazard characterization, …

Go to article

Contamination And Changes Of Food Factors During Processing With Modeling Applications - Safety Related Issues, S. Sheen Jul 2020

Contamination And Changes Of Food Factors During Processing With Modeling Applications - Safety Related Issues, S. Sheen

Journal of Food and Drug Analysis

Chemical and microbiological contaminations of food during processing and preservation can result in foodborne illness outbreaks and/or poisoning. Chemical contaminations can occur through exposure of foods to illegal additives, pesticides and fertilizer residues, toxic compounds formed by chemical reactions, and are easier to control than illnesses caused by microorganisms. In general, chemical reactions in food can be described using the first-order kinetic models. Food quality factors related to nutrition, color, texture, etc. are typically affected by temperature, pH, moisture content, as well as microbial growth. However, modeling the growth and inactivation of microorganisms is much more difficult and complex than …

Go to article

Comparison Of Anti-Hyperglycemic Activities Between Low- And High-Degree Of Polymerization Procyanidin Fractions From Cacao Liquor Extract, Y. Yamashita, M. Okabe, M. Natsume, H. Ashida Jul 2020

Comparison Of Anti-Hyperglycemic Activities Between Low- And High-Degree Of Polymerization Procyanidin Fractions From Cacao Liquor Extract, Y. Yamashita, M. Okabe, M. Natsume, H. Ashida

Journal of Food and Drug Analysis

Procyanidins are thought to be effective for prevention of hyperglycemia. To clarify the degree of polymerization (DP) of procyanidins on anti-hyperglycemic effects, we prepared low-DP (DP ≤ 3) and high-DP (DP ≥ 4) procyanidin fractions from cacao liquor, and examined whether these procyanidin fractions prevent hyperglycemia in vitro. We found that both fractions promoted glucose uptake in L6 myotubes in a dose-dependent manner accompanied by translocation of GLUT4 to the plasma membrane. Moreover, both fractions stimulate phosphorylation of AMP-activated protein kinase (AMPK). In these beneficial effects, low-DP fraction was more effective than high-DP one. On the other hand, high-DP fraction …

Go to article

Challenges In Food Nanoscale Science And Technology, B.C. Bryksa, R.Y. Yada Jul 2020

Challenges In Food Nanoscale Science And Technology, B.C. Bryksa, R.Y. Yada

Journal of Food and Drug Analysis

Nanotechnology allows for the possibility to manipulate and modify material and systems on the nanoscale to produce altered characteristics that may differ greatly from those on the macroscale. The potential applications of nanoscale science and technology in the food area are emerging in such areas as safety testing, packaging, authenticity/authentication, and product development through novel functional ingredients and nutrient delivery systems. However, as with all new technologies, it is these potentially new and unique properties that will require rigorous safety testing and risk/benefit analysis to ensure that public and environmental concerns are addressed. The latter will be of particular importance …

Go to article

Cancer Preventive Activities Of Tea Polyphenols, C.S. Yang, H. Jin, F. Guan, Y.-K. Chen, H. Wang Jul 2020

Cancer Preventive Activities Of Tea Polyphenols, C.S. Yang, H. Jin, F. Guan, Y.-K. Chen, H. Wang

Journal of Food and Drug Analysis

The cancer preventive activities of tea (Camellia Sinensis Theaceae) have been investigated extensively. Green tea polyphenols have been shown to inhibit tumorigenesis in different animal models, including those for cancers of the lung, oral cavity, esophagus, stomach, small intestine, colon, bladder, liver, pancreas, skin, prostate and mammary glands. Enhancement of apoptosis, suppression of cell proliferation, and inhibition of angiogenesis have been shown to be associated with the inhibition of carcinogenesis by tea polyphenols in animals. Many studies in cell lines have demonstrated the modulation of signal transduction and metabolic pathways by (-)-epigallocatechin-3-gallate (EGCG), the most abundant and active polyphenol in …

Go to article

Food Safety Research Of The Agricultural Research Service, Usda, S.-I. Tu Jul 2020

Food Safety Research Of The Agricultural Research Service, Usda, S.-I. Tu

Journal of Food and Drug Analysis

The Agricultural Research Service (ARS) is the in-house research institute of the United States Department of Agriculture (USDA). One of the key missions of ARS is to provide, through scientific research, the means to ensure that the food supply is safe and secure for consumers and that food and feed meet foreign and domestic regulatory requirements. Food safety research seeks ways to assess, control or eliminate potentially harmful food contaminants, including both introduced and naturally occurring pathogenic bacteria, viruses and parasites, toxins and non-biological-based chemical contaminants, mycotoxins and plant toxins. Food safety is a global issue; thus, the research program …

Go to article

Nuts For Diabetes Prevention And Management, A. Kamil, C.-Y.O. Chen Jul 2020

Nuts For Diabetes Prevention And Management, A. Kamil, C.-Y.O. Chen

Journal of Food and Drug Analysis

Type 2 diabetes mellitus is an important preventable disease and a growing public health problem. Epidemiologic and clinical studies suggest that healthy eating, physical activity, and BW control are the main driving forces to reduce diabetes risk. Owing to their low available carbohydrate content, favorable fat and protein profile as well as phytonutrient content, nut consumption has been associated with a reduced risk of development and management of diabetes. Nuts, by virtue of its cardioprotective actions, have also been shown to reduce biomarkers of risk factors for diabetic complications. Although more studies are warranted, the emerging picture is that nut …

Go to article

The Selectivity And Impact Of Polyphenols-Protein Kinases Interactions For Chemoprevention, D.-X. Hou, T. Kumamoto, H. Ishida, A. Hisanaga Jul 2020

The Selectivity And Impact Of Polyphenols-Protein Kinases Interactions For Chemoprevention, D.-X. Hou, T. Kumamoto, H. Ishida, A. Hisanaga

Journal of Food and Drug Analysis

Phosphorylation of target proteins by protein kinases leads to the activation of cellular signaling pathways, which induce a great number of biological processes including cell growth, differentiation, development, and death. Although the activities of protein kinases are stringently regulated in homeostasis system, protein kinases can be deregulated under pathological conditions, leading to perturbation of protein kinase-mediated cell signaling pathways and resulting in various disorders including cancer, diabetes, and inflammation. The data from the Human Genome Project has revealed that 518 protein kinases are encoded in the human genome, thereby creating an enormous repertoire of potential targets for chemoprevention. Polyphenols, as …

Go to article

First Prev Next Last