Digital Commons Network^™

Intention From God: Midwives And Professional Physicians In Late Nineteenth-Century Alabama, Sheila Blair

Vulcan Historical Review

pp. 63-71

Be Covid Safe, Opeyemi Akinrinsola, Abigail Corkum, Karyn Furcolo, Christina Gareis, Dorothy Tang

Foundations of Public Health - Infographics

No abstract provided.

Guide To Mask Wearing 101, Laiquannah Hason, Jeremiah Kinsey, Kevin O'Connor

Foundations of Public Health - Infographics

No abstract provided.

"I Don't Like Wearing A Mask", Priyanka Bhatt, Devesh Dajee, Neha Jha, Ruhi Shah

Foundations of Public Health - Infographics

No abstract provided.

The 3 W'S To Staying Safe On & Off Campus During Covid-19, Amanda Guth, Matthew Kermitz, Kate Minke, Raya Patel

Foundations of Public Health - Infographics

No abstract provided.

Controlling The Waves Of Covid-19, Joseph M. Callaghan, Emily Mcdermott, Sofia Mitro, Christopher Stuever

Foundations of Public Health - Infographics

No abstract provided.

Spread Holiday Cheer, Not Covid-19, Sameh Gomaa, Sana Khalid, Michelle St. Omer Roy

Foundations of Public Health - Infographics

No abstract provided.

It's Your Responsibility, Simon Chen, Devanshi Dash, Jaime Nassur

Foundations of Public Health - Infographics

No abstract provided.

Carcass Traits, Meat Quality, And Sensory Attributes Of Fast-Growing Broilers Givenoutdoor Access At Different Ages, Muhammad Zaid, Jibran Hussain, Athar Mahmud, Khalid Javed, Muhammad Shabir Shaheen, Muhammad Usman, Abdul Ghayas, Sohail Ahmad

Turkish Journal of Veterinary & Animal Sciences

This study evaluated the effect of outdoor access offered to fast-growing broilers at different ages and its impact on meat quality attributes. A total of 200 straight-run broilers were arranged according to the completed randomized design and distributed into 4 treatment groups. The treatments were replicated 5 times; each replicate consisted of 10 birds. The treatment included age at exposure to outdoor access including day 21, day 28, and day 35, and a control group in which the birds were reared at an indoor facility for up to 56 days. Taste, flavor, juiciness, and overall acceptability of breast meat were …

Iron-Rich Foods, Anemia, And Malaria In Primary School Children In Southern Ethiopia And Zambia, Julianne Fay

NUTR/GLST 498b: Global Research Experiences in Nutrition and Health

PURPOSE: To examine the relationship between iron-deficient anemia and malaria in primary school children in Southern Ethiopia and Zambia and assess the correlation between diet and health status.

METHODS: Market inventories, observations at health outposts, and interviews and anthropometric assessments of 6th and 7th grade students.

RESULTS: Both Ethiopia and Zambia had 20 iron-rich foods available in local markets. Only liver consumption was associated with malaria experience; those who consumed liver were significantly less likely to have had the disease (p

DISCUSSION: Given the high prevalence of malaria in Southern Ethiopia and Zambia, and the correlation between liver consumption and …

Obituary: Thomas Henry Kunz (1938–2020), Allen Kurta, Winifred F. Frick, M. Brock Fenton, Polly Campbell, Gary F. Mccracken, Robert M. Timm, Hugh H. Genoways

University of Nebraska State Museum: Mammalogy Papers

Dr. Thomas Henry Kunz, an internationally recognized expert on the ecology and behavior of bats and Professor at Boston University, passed away on April 13, 2020 in Dedham, Massachusetts, at the age of 81 as the result of complications from COVID-19. “Tom,” to his many friends and colleagues, was born on June 11, 1938 in Independence, Missouri, to William H. and Edna F. (Dornfeld) Kunz. He married Margaret Louise Brown on December 27, 1962 in Faucett, Missouri, Margaret’s hometown. Two children were born to Margaret and Tom—Pamela Kunz (Jeffrey Kwan) and David Kunz (Nicole, née D’Angelo), and five grandchildren.

As …

Macrophage Lc3-Associated Phagocytosis Is An Immune Defense Against Streptococcus Pneumoniae That Diminishes With Host Aging, Megumi Inomata, Shuying Xu, Pallavi Chandra, Simin N. Meydani, Genzou Takemura, Jennifer A. Philips, John M. Leong

Open Access Publications

No abstract provided.

Host Transcriptional Response To Persistent Infection With A Live-Attenuated Porcine Reproductive And Respiratory Syndrome Virus Strain, Jayeshbhai Chaudhari, Chia-Sin Liew, Aspen M. Workman, Jean-Jack Riethoven, David J. Steffen, Sarah Vitosh-Sillman, Hiep Vu

Nebraska Center for Virology: Faculty Publications

Both virulent and live-attenuated porcine reproductive and respiratory syndrome virus (PRRSV) strains can establish persistent infection in lymphoid tissues of pigs. To investigate the mechanisms of PRRSV persistence, we performed a transcriptional analysis of inguinal lymphoid tissue collected from pigs experimentally infected with an attenuated PRRSV strain at 46 days post infection. A total of 6404 differentially expressed genes (DEGs) were detected of which 3960 DEGs were upregulated and 2444 DEGs were downregulated. Specifically, genes involved in innate immune responses and chemokines and receptors associated with T-cell homing to lymphoid tissues were down regulated. As a result, homing of virus-specific …

First Records Of Established Populations Of Ixodes Scapularis (Acari: Ixodidae) Collected From Three Nebraska Counties, Lindsey E. Nielsen, Roberto Cortinas, Paul D. Fey, Peter C. Iwen, David H. Nielsen

School of Veterinary and Biomedical Sciences: Faculty Publications

Reported cases of Lyme disease in Nebraska have been assumed to be imported from other endemic areas. Previous surveillance efforts provided no evidence of established populations as only individual specimens of Ixodes scapularis (Say) had been collected. In the winter of 2018, adult I. scapularis were found on a dog at Two Rivers State Recreation Area, Douglas County, prompting tick collection at the site and nearby natural areas. In May 2019, all life stages of host-seeking I. scapularis were collected using dragging and flagging techniques in sites located near the Platte River in Douglas, Sarpy, and Saunders counties. This is …

Intimate Attachment Of Escherichia Coli O157:H7 To Urinary Bladder Epithelium In The Gnotobiotic Piglet Model, Rodney A. Moxley, Tom W. Bargar, Stephen D. Kachman, Diane R. Baker, David H. Francis

School of Veterinary and Biomedical Sciences: Faculty Publications

Enterohemorrhagic Escherichia coli (EHEC), a pathogenic subset of Shiga toxin-producing E. coli (STEC), is an important cause of hemorrhagic colitis and hemolytic–uremic syndrome (HUS), and a rare cause of urinary tract infections (UTIs) with associated HUS. EHEC strains attach intimately to intestinal epithelium with formation of actin pedestals (attaching-effacing (A/E) lesions); however, the mechanism of EHEC attachment to the uroepithelium is unknown. We conducted a retrospective study on archived urinary bladder specimens from gnotobiotic piglets that naturally developed cystitis associated with EHEC O157:H7 infection following oral inoculation and fecal shedding. Paraffin-embedded bladder tissues from three piglets with cystitis and immunohistochemical …

Triggers Of Inflammatory Heart Disease, Ninaad Lasrado, Bharathi Yalaka, Jay Reddy

School of Veterinary and Biomedical Sciences: Faculty Publications

Inflammatory heart disease (IHD) is a group of diseases that includes pericarditis, myocarditis, and endocarditis. Although males appear to be more commonly affected than females, IHD can be seen in any age group. While the disease can be self-limiting leading to full recovery, affected individuals can develop chronic disease, suggesting that identification of primary triggers is critical for successful therapies. Adding to this complexity, however, is the fact that IHD can be triggered by a variety of infectious and non-infectious causes that can also occur as secondary events to primary insults. In this review, we discuss the immunological insights into …

Current Status Of Zika Virus Vaccines: Successes And Challenges, Aryamav Pattnaik, Bikash R. Sahoo, Asit K. Pattnaik

School of Veterinary and Biomedical Sciences: Faculty Publications

The recently emerged Zika virus (ZIKV) spread to the Americas, causing a spectrum of congenital diseases including microcephaly in newborn and Guillain-Barré syndrome (GBS) in adults. The unprecedented nature of the epidemic and serious diseases associated with the viral infections prompted the global research community to understand the immunopathogenic mechanisms of the virus and rapidly develop safe and efficacious vaccines. This has led to a number of ZIKV vaccine candidates that have shown significant promise in human clinical trials. These candidates include nucleic acid vaccines, inactivated vaccines, viral-vectored vaccines, and attenuated vaccines. Additionally, a number of vaccine candidates have been …

Rapid Differentiation Of Moraxella Bovoculi Genotypes 1 And 2 Using Maldi-Tof Mass Spectrometry Profiles, Matthew M. Hille, Aaron M. Dickey, Kara Robbins, Michael L. Clawson, John Dustin Loy

School of Veterinary and Biomedical Sciences: Faculty Publications

Moraxella bovoculi is the most frequently isolated bacteria from the eyes of cattle with Infectious Bovine Keratoconjunctivitis (IBK), also known as bovine pinkeye. Two distinct genotypes of M. bovoculi, genotype 1 and genotype 2, were characterized after whole genome sequencing showed a large degree of single nucleotide polymorphism (SNP) diversity within the species. To date, both genotypes have been isolated from the eyes of cattle without clinical signs of IBK while only genotype 1 strains have been isolated from the eyes of cattle with clinical signs of IBK. We used 38 known genotype 1 strains and 26 known genotype …

Evaluation Of A Photograph-Based Citizen Science Program As A Tick Surveillance And Prevention Education Tool, Heather Lynn Kopsco

Open Access Dissertations

The multitude of factors fueling the escalation in tick-borne disease in the United States is further complicated by gaps in public knowledge and inconsistent adherence to tick-bite prevention behaviors. Passive tick surveillance is a growing strategy to monitor tick species trends and associated pathogen prevalence across the country. Most practice involves citizens shipping encountered ticks to a laboratory for identification and pathogen testing, but given potential delays in mailing and processing time, tick bite victims may be placed outside the window of potential prophylactic options, or under unnecessary antibiotic administration. Recently, photographed-based tick surveillance has been shown to be a …

Pharmacokinetics, Pharmacodynamics And Dosing Regimen Of Long-Acting Oxytetracycline In Nile Tilapia (Oreochromis Niloticus), Kananuch Vasuntrarak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Antimicrobial resistance has become a serious global problem and is steadily increasing worldwide. In aquaculture, there are limited antimicrobial options for treatment. Thus, there are growing needs for more specific dosing regimens of existing antimicrobial drugs that are not only to obtain therapeutic efficacy but also to minimize the resistance of pathogens. The purposes of this study were to determine pharmacokinetics (PK) of long-acting oxytetracycline (OTC) after intraperitoneal (IP) administration in Nile tilapia. One hundred and twenty healthy male tilapia (450±37.47 g) were divided into two experimental groups (60 fish/group). Each group received OTC-LA single IP injection at dosage of …

Evaluation Of The Relationship Between Centrality And Individual-Level Characteristics Among Pwid, Benjamin Skov

Open Access Master's Theses

Background: People who inject drugs (PWID) are a well-identified risk population for HIV infection. The risk networks of PWID have been implicated as possible modulators of both HIV risk and educational interventions among this population. In order to further understand the nature of risk networks, we examined how individual characteristics were associated with influential network position based on high closeness, betweenness, or eigenvector network centrality. These centrality measures assess an individual’s importance or potential to influence others based on their connections, closeness is based on proximity to others, betweenness on acting as an intermediary between others, and eigenvector on connection …

Synthesis And The Genetic Encoding Of Novel Lysine Post-Translational Modifications, Sahan A. Galbada Liyanage

Theses and Dissertations

Post-translational modifications (PTMs) play a significant role in regulating cell signaling and regulating the inner cellular environment. The study of PTMs and their primary biological functions is critical for the development of new medicines targeting the pathways and biomolecules responsible for the PTMs.

Previous studies revealed the direct coupling of the β -hydroxybutyryl lysine (K_BHB) modification with the gene expression. K_BHB in histone proteins links metabolism to epigenetics and gene expression and enables to study in-depth, how cell metabolism controls the gene expression and vice versa. Similar novel histone modification, K_Lac, attracts a special interest …

Tick-Borne Infections In New Hampshire: An Evaluation Of The Diagnostic Process In A Local Patient Population, Katherine Anderson

Honors Theses and Capstones

Overall, approximately 95 percent of reported cases of vector-borne disease were associated with ticks, making these the most medically important group of arthropods in the United States.¹ Despite the prevalence of tick-borne infections, the process for the diagnosis of this condition is not well studied. This study aims to analyze data from a pool of 100 patients who underwent testing for tick-borne disease in the same institution in Dover, New Hampshire during the most recent peak tick season of 2019. Information utilized in this study included: patient age, sex, location of testing (inpatient versus outpatient), diagnostic testing methods used …

The Cholera Crisis In Yemen: Case Studies On Vulnerability And Resilience In Sana'a, Al Hudaydah, And Ma'areb, Noor Albannein A. Al-Saad

Honors Theses and Capstones

The largest recorded cholera epidemic in history is happening right now in Yemen, a country which has reported over 2 million cases of cholera as of 2020. Yemen has a history of endemic cholera, but prolonged conflict in the country has led to deteriorating conditions that have triggered massive outbreaks of the disease. The purpose of this study is to investigate the direct and indirect causes of the cholera epidemic in Yemen by proposing factors that may confer vulnerability and resilience in Yemeni governorates. Case studies were constructed for three governorates: Sana’a and the inner municipality of Amanat Al Asimah; …

Mothers’ And Community Stakeholders’ Perspectives About The Vitamin A Supplementation Program In Nigeria, Olufolakemi Mercy Anjorin

Walden Dissertations and Doctoral Studies

Vitamin A deficiency (VAD) affects about one third of children under the age of five in Nigeria. There is low uptake of biannual Vitamin A supplementation (VAS) used since year 2010 as the national response to addressing VAD among children 6 to 59 months. Yet, there is limited research on barriers or facilitators to uptake of VAS. The purpose of this study was to examine the perspectives of stakeholders about the VAS program in Nigeria. The theoretical underpinning was the social marketing framework. The central question related to the views of stakeholders toward the VAS program, and their perception about …

Delay In Antibiotic Administration Is Associated With Mortality Among Septic Shock Patients With Staphylococcus Aureus Bacteremia, Keith A. Corl, Zeba, Aisling R. Caffrey, Matthew Hermenau, Vrishali Lopes, Gary Phillips, Roland C. Merchant, Mitchell Levy, Kerry L. Laplante

Pharmacy Practice and Clinical Research Faculty Publications

Objectives: The relationship between the timing of antibiotics and mortality among septic shock patients has not been examined among patients specifically with Staphylococcus aureus bacteremia.

Design: Retrospective analysis of a Veterans Affairs S. aureus bacteremia database.

Settings: One-hundred twenty-two hospitals in the Veterans Affairs Health System.

Patients: Patients with septic shock and S. aureus bacteremia admitted directly from the emergency department to the ICU from January 1, 2003, to October 1, 2015, were evaluated.

Interventions: Time to appropriate antibiotic administration and 30-day mortality.

Measurements and Main Results: A total of 506 patients with S. aureus bacteremia and septic shock were …

Disseminated Effects In Agent Based Models: A Potential Outcomes Framework And Application To Inform Pre-Exposure Prophylaxis Coverage Levels For Hiv Prevention, Ashley L. Buchanan, Bessey, William C. Goedel, Maximilian King, Eleanor J. Murray, Samuel Friedman, M. Elizabeth Halloran, Brandon D.L. Marshall

Pharmacy Practice and Clinical Research Faculty Publications

Pre-exposure prophylaxis (PrEP) for HIV prevention may not only benefit the individual who uses it, but also their uninfected sexual risk contacts. We developed an agent-based model using a novel trial emulation approach to quantify disseminated effects of PrEP use among men who have sex with men in Atlanta, USA from 2015 to 2017. Components (subsets of agents connected through partnerships in a sexual network, but not sharing partnerships with any other agents) were first randomized to an intervention coverage level or control, then within intervention components, eligible agents were randomized to PrEP. We estimated direct and disseminated (indirect) effects …

Identification And Evaluation Of Epidemic Prediction And Forecasting Reporting Guidelines: A Systematic Review And A Call For Action, Simon Pollett, Michael Johansson, Matthew Biggerstaff, Lindsay C. Morton, Sara L. Bazaco, David Brett-Major, Anna M. Stewart-Ibarra, Julie A. Pavlin, Suzanne Mate, Rachel Sippy, Laurie J. Hartman, Nicholas G. Reich, Irina Maljkovic Berry, Jean-Paul Chretien, Benjamin M. Althouse, Diane Myer, Cecile Viboud, Caitlin Rivers

Journal Articles: Epidemiology

INTRODUCTION: High quality epidemic forecasting and prediction are critical to support response to local, regional and global infectious disease threats. Other fields of biomedical research use consensus reporting guidelines to ensure standardization and quality of research practice among researchers, and to provide a framework for end-users to interpret the validity of study results. The purpose of this study was to determine whether guidelines exist specifically for epidemic forecast and prediction publications.

METHODS: We undertook a formal systematic review to identify and evaluate any published infectious disease epidemic forecasting and prediction reporting guidelines. This review leveraged a team of 18 investigators …

Mycobacterium Tuberculosis Beijing Lineage And Risk For Tuberculosis In Child Household Contacts, Peru, Chuan-Chin Huang, Alexander L. Chu, Mercedes C. Becerra, Jerome T. Galea, Roger Calderón, Carmen Contreras, Rosa Yataco, Zibiao Zhang, Leonid Lecca, Megan B. Murray

Social Work Faculty Publications

Few studies have prospectively compared the relative transmissibility and propensity to cause disease of Mycobacterium tuberculosis Beijing strains with other human-adapted strains of the M. tuberculosis complex. We assessed the effect of Beijing strains on the risk for M. tuberculosis infection and disease progression in 9,151 household contacts of 2,223 culture-positive pulmonary tuberculosis (TB) patients in Lima, Peru. Child contacts exposed to Beijing strains were more likely than child contacts exposed to non-Beijing strains to be infected at baseline, by 12 months of follow-up, and during follow-up. We noted an increased but nonsignificant tendency for child contacts to develop TB. …

Exploring And Supporting Tenant Activism In Upstate New York, Catherine Porter

Renée Crown University Honors Thesis Projects - All

No abstract provided.