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From Discovery To Delivery: Public Sector Development Of The Rvsv-Zebov Ebola Vaccine, Matthew Herder, Janice Graham, Richard Gold

Articles, Book Chapters, & Popular Press

The discovery and development of the Ebola rVSV-ZEBOV vaccine challenge the common assumption that the research and development for innovative therapeutic products and vaccines is best carried out by the private sector. Using internal government documents obtained through an access to information request, we analyze the development of rVSV-ZEBOV by researchers at Canada’s National Microbiology Laboratory beyond its patenting and licensing to a biotech company in the United States in 2010. According to government documentation, the company failed to make any progress toward a phase 1 clinical trial until after the WHO Public Health Emergency of International Concern freed substantial …

Novel Roles Of Rip2 In Inflammation And Resolution, Michael Shehat

Electronic Theses and Dissertations, 2020-2023

Receptor-interacting protein 2 (RIP2) is a kinase which mediates signaling downstream of the bacterial peptidoglycan sensors Nucleotide-binding Oligomerization Domain (NOD) 1 and 2. Genetic loss or pharmaceutical inhibition of RIP2 has been shown to be beneficial in multiple inflammatory disease models with the effects largely attributed to reducing pro-inflammatory signaling downstream of peptidoglycan recognition. However, given the widespread expression of this kinase and its reported interactions with numerous other proteins, it is possible that RIP2 has many other unappreciated roles. In this work, we report the involvement of RIP2 in two novel pathways. First, we demonstrate a NOD2 dependent role …

Covid-19 And Prisoners’ Rights, Gregory Bernstein, Stephanie Guzman, Maggie Hadley, Rosalyn M. Huff, Alison Hung, Anita N.H. Yandle, Alexis Hoag, Bernard E. Harcourt

Faculty Scholarship

As COVID-19 continues to spread rapidly across the country, the crowded and unsanitary conditions in prisons, jails, juvenile detention, and immigration detention centers leave incarcerated individuals especially vulnerable. This chapter will discuss potential avenues for detained persons and their lawyers seeking to use the legal system to obtain relief, including potential release, during this extraordinary, unprecedented crisis.

Apocalypse Now: Covid-19 And The Sf Imaginary, Gerry Canavan, Jennifer Cooke, Caroline Edwards

English Faculty Research and Publications

The following conversation was conducted via Google Docs between 1st May and 23rd June 2020. The participants were Gerry Canavan (Marquette University), Jennifer Cooke (Loughborough University) and Caroline Edwards (Birkbeck College, London). Gerry is President of the SFRA; his books include Green Planets: Ecology and Science Fiction (2014), co-edited with Kim Stanley Robinson, Octavia E. Butler (2016), and most recently The Cambridge History of Science Fiction (2019), co-edited with Eric Carl Link. Jennifer is a poet and academic; her first book was on Legacies of Plague in Literature, Theory, and Film (2009) while her most recent is Contemporary Feminist Life-Writing: …

Hiv Vaccine Development: The Importance Of Gp120 Variable Loop 3 For The Survival Of The Human Immunodeficiency Virus And The Potency Of The Neutralizing Antibody To Bind To The Variable Loop 3, Riham Hussien

Biology and Microbiology Graduate Students Plan B Research Projects

The tendency for the Human Immunodeficiency Virus (HIV) to proliferate and mutate it’s trimeric envelop (Env), is one of the reasons why it’s a challenge for an antibody-based vaccine to be developed. Glycoprotein 160 (gp160,) which consists of glycoprotein 120 (gp120) and glycoprotein 41 (gp41), is the main focus for a research vaccine design. Gp120 consists of an outer membrane, inner membrane and bridging sheet. The protein is trimeric, and non-covalently binds to gp41. The outer domain is where the neutralizing antibody bind, such as 2G12, immunoglobulin G1b12, and anti-V3 antibodies. V3 stands for the Variable loop 3, gp120 has …

Evidence-Based Health Solutions For Challenges Women Face During Pandemics Like Covid-19: A Systematic Review Protocol, Zhaohui Su, Shelly Wagers, Emme Lopez, Lori Ann Terjesen, Jaffar Abbas, Feng Shi, Caifeng Wang, Yuyang Cai

Criminology Faculty Publications

No abstract provided.

Syringe Exchange Programs And Emergency Department Use For Drug Overdoses In Kentucky, Timothy Williams

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

In 2015, syringe exchange programs (SEPs) were legalized in Kentucky as part of a response to the high and rising morbidity and mortality associated with injection drug use, particularly opioids. In addition to their primary function of preventing the spread of some infectious diseases by providing injection drug users (IDUs) with easy access to sterile injection equipment, SEPs may also offer ancillary services such as referrals to primary care providers and substance abuse and mental health treatment, as well as safe injection education and naloxone training. These ancillary services are intended to improve the overall health of IDUs and the …

Scientist Of The Week!, Sarah L. Sheffield, Lisette Melendez, Kristin Houdyshell, Mathew Burgos

School of Geosciences Faculty and Staff Publications

No abstract provided.

Uncovering Host-Microbiome Interactions In Global Systems With Collaborative Programming: A Novel Approach Integrating Social And Data Sciences [Version 1; Peer Review: Awaiting Peer Review], Jenna Oberstaller, Swamy Rakesh Adapa, Guy Dayhoff Ii, Justin Gibbons, Gregory S. Herbert

School of Geosciences Faculty and Staff Publications

Microbiome data are undergoing exponential growth powered by rapid technological advancement. As the scope and depth of microbiome research increases, cross-disciplinary research is urgently needed for interpreting and harnessing the unprecedented data output. However, conventional research settings pose challenges to much-needed interdisciplinary research efforts due to barriers in scientific terminologies, methodology and research-culture. To breach these barriers, our University of South Florida OneHealth Codeathon was designed to be an interactive, hands-on event that solves real-world data problems. The format brought together students, postdocs, faculty, researchers, and clinicians in a uniquely cross-disciplinary, team-focused setting. Teams were formed to encourage equitable distribution …

On Environmental Law, Climate Change, And National Security Law, Mark P. Nevitt

Faculty Articles

This Article offers a new way to think about climate change. Two new climate change assessments—the 2018 Fourth National Climate Assessment (“NCA”) and the United Nations Intergovernmental Panel on Climate Change’s Special Report on Climate Change— prominently highlight climate change’s multifaceted national security risks. Indeed, not only is climate change an environmental problem, it also accelerates existing national security threats, acting as both a “threat accelerant” and “catalyst for conflict.” Further, climate change increases the intensity and frequency of extreme weather events while threatening nations’ territorial integrity and sovereignty through rising sea levels. It causes both internal displacement within nations …

Development Of Efficient Waste Management System For Guwahati City, Prantar Jyoti Talukdar

Chulalongkorn University Theses and Dissertations (Chula ETD)

As on today, in view of the exponential increase of population, fast urbanisation, technical advancements etc., globally, the waste management is becoming a subject of great concern. Apart from dealing with waste only, any waste management system has to encompass many other variants, including - environments, pollution, public health & hygiene, local eco-system etc. So, it is difficult to frame a common global policy or a country’s specific policy to meet all the requirements of the local service providers and customers. Preferentially, any waste management system need to be developed as per the requirements of the local endeavours. In this …

The Relationship Between Oral Health Literacy And Periodontal Health Status Among The Elderly In Panare, Pattani, Thailand, Panat Piyakhunakorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to determine the association between oral health literacy (OHL) and periodontal status among Thailand's older population. This cross-sectional study was conducted between 1 July and 30 September 2020 at HPHs in, Panare, Pattani, Thailand. A total of 216 independent living older adults, participated in the study. OHL data were obtained using the Thai version of Health Literacy in Dentistry (HeLD‐Th). Trained interviewers performed face-to-face interviews for oral health-related behaviours information. The periodontal status was collected through intra-oral examination by a calibrated examiner. Data were analyzed using the SPSS version 22. Mann–Whitney U tests, Chi-Square tests, and Binary …

State Obligations Under Public International Law During Pandemics, Michaela S. Halpern

Emory International Law Review Recent Developments

COVID-19 became an international pandemic affecting every country and threatening a global economic collapse. This Article examines countries' obligations under public international law to prevent and contain pandemics, and subsequent responsibilities to help other countries during pandemics. International Human Rights law recognizes a right to health and includes obligations. Nonetheless, it lacks a sufficient enforcement mechanism. Pandemics are analogous to war; therefore, the Responsibility to Protect (R2P) can help as countries utilize R2P to protect against atrocities. This Article argues that R2P is not merely a responsibility to protect against the worst that humankind has to offer but against the …

Estimating The Need For Additional Bankruptcy Judges In Light Of The Covid-19 Pandemic, Benjamin Iverson, Jared A. Ellias, Mark Roe

Faculty Publications

In this Article, we present the first effort to use an empirical approach to bolster the capacity of the bankruptcy system during a national crisis—here, the COVID-19 crisis. We provide two analyses, one using data from May 2020, very early on in the crisis, and another using data from September 2020, closer to the publication of this Article. Our analysis is based on an empirical observation: Historically, an increase in the unemployment rate has been a leading indicator of a rise in bankruptcy filings. If this historical trend continues to hold, the May 2020 unemployment rate of 13.3% would have …

Covid-19 And First Nations’ Responses, Aimée Craft, Deborah Mcgregor, Jeffery G. Hewitt

Articles & Book Chapters

This chapter considers the federal government’s fettering of jurisdiction through inaction in the areas of clean water and housing. We consider a small sample of First Nations’ responses, taken on the basis of their assertions of jurisdiction and responses to the particular needs and circumstances of their communities. We conclude that First Nations are best positioned to make policy and law in response to COVID-19, and that the federal government can and must work with First Nations communities on resourcing their plans for wellness and emergency preparedness in relation to the pandemic, in accordance with a sui generis application of …

Sindbis Virus Infects Specific Gut Cells For Replication And Dissemination From The Posterior Midgut Of Mosquitoes, Yani P. Ahearn

UNF Graduate Theses and Dissertations

Abstract

Sindbis virus (SINV), a member of the genus Alphavirus, is the protype virus used to gain insight into other disease-causing Alphaviruses. As a mosquito-borne-virus (arbovirus), SINV transit in adult female mosquitoes includes attachment to the gut lumen and entry into the midgut cells, followed by replication and dissemination into the hemolymph through yet unknown specific mechanisms. Free-mated adult females, aged day 5-7, were fed a viremic bovine blood suspension via blood sausage at a final SINV titer at 107 PFU/ml. Midguts from fully engorged mosquitoes were dissected on day 5 and 7 post-bloodmeal and further examined by immunolabeling using …

Basigin As An Immune Mediator In The Cns, Alicia Gonzalez

UNF Graduate Theses and Dissertations

Chronic inflammation is a hallmark of many neurodegenerative disorders. Although the central nervous system (CNS) can stave peripheral pathogens from crossing the blood-brain barrier (BBB) through a network of continuous endothelia, astrocytes, and pericytes, prolonged exposure to a pathogen can comprise this barrier. Basigin, a cell adhesion molecule, is found on the surface of endothelial cells and has been demonstrated to interact with toll-like receptor 4 (TLR4). TLR4 recognizes lipopolysaccharide (LPS), found on the outer membrane of Gram-negative bacteria. The activation of TLR4 produces pro-inflammatory cytokines, like IL-6. The present study aims to address the expression pattern of Basigin gene …

Reemergence Of Guadalupe Fur Seals In The U.S. Pacific Northwest: The Epidemiology Of Tranding Events During 2005–2016, Erin D'Agnese, Dyanna M. Lambourn, James Rice, Debbie Duffield, Jessica L. Huggins, Terry Spraker, Stephen A. Raverty, Tetiana Kuzmina, Micheal E. Grigg, Kristin Wilkinson, Multiple Additional Authors

Biology Faculty Publications and Presentations

Guadalupe fur seals (GFS), Arctocephalus philippii townsendi, an U.S. Endangered Species Act threatened pinniped, have recently reappeared in their historic range along the western seaboard of the continental United States. Starting 2005 through 2016, 169 GFSs stranded in Washington and Oregon, involving two designated unusual mortality events. The circumstances surrounding GFS strandings, mortality, and their increased presence in Oregon and Washington were analyzed during this study. Detailed necropsies, histopathology (n = 93), and epidemiological analysis found three main causes of death (COD): emaciation (44%), trauma (29%), and infectious disease (19%) and the factors associated with overall strandings and …

Washington University Magazine, November 2020

Washington University Magazine

No abstract provided.

Federal Detention And “Wild Facts” During The Covid-19 Pandemic, Gabriel A. Fuentes

Journal of Criminal Law and Criminology

No abstract provided.

Etsu Health Annual Report - 2020, 2020

ETSU Health Annual Reports

No abstract provided.

Vancomycin Dosing Practices Among Critical Care Pharmacists: A Survey Of Society Of Critical Care Medicine Pharmacists, Alexander H. Flannery, Drayton A. Hammond, Douglas R. Oyler, Chenghui Li, Adrian Wong, Andrew P. Smith, Qiu Min Yeo, Whitney Chaney, Caitlin E. Pfaff, Angela M. Plewa-Rusiecki, Paul Juang

Pharmacy Practice and Science Faculty Publications

Introduction: Critically ill patients and their pharmacokinetics present complexities often not considered by consensus guidelines from the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Prior surveys have suggested discordance between certain guideline recommendations and reported infectious disease pharmacist practice. Vancomycin dosing practices, including institutional considerations, have not previously been well described in the critically ill patient population.

Objectives: To evaluate critical care pharmacists' self-reported vancomycin practices in comparison to the 2009 guideline recommendations and other best practices identified by the study investigators.

Methods: An online survey developed by the …

The Persisting Threats Of Cholera: A Cyclical Public Health Problem In Ghana, Rita Laryea Amediavor

Browse all Theses and Dissertations

The prevalence of communicable diseases continues to be one of the continent's leading causes of deaths. Cholera is a waterborne disease triggered by toxigenic strains of the Gram-negative bacteria Vibrio Cholerae O1 strain and less common O139 strain. with symptoms such as severe acute watery diarrhea and vomiting leading to dehydration, progressing to hypovolemic shock and death if not treated timely due to its short incubation period (Pasetto et al., 2018). West African countries are largely portrayed as endemic to cholera, though the dynamics of outbreaks in these developing countries remain largely uncertain. The purpose of the study is to …

Habitat Selection Across A Temperature And Nutrient Gradient By Cope’S Grey Treefrog (Hyla Chrysoscelis) And The Mosquito, Culex Restuans, Sarah Christine Mcnamara

Electronic Theses and Dissertations

Habitat selection by pond breeding amphibians and insects is often critical for larval survival, performance, and resulting parental fitness, since there is typically little parental care beyond oviposition site choice. Numerous axes of patch quality have been identified and quantified, but species with varied life histories may differently shift perception of habitat quality as changes in global climate increase water temperatures and rates of eutrophication. Three outdoor mesocosm experiments were conducted using two species with complex life cycles and very different life histories; Hyla chrysoscelis, or Cope’s Gray tree frog, and the mosquito (Culex restuans). Two mesocosm experiments were conducted …

Transgenerational Effects Of Mycoplasma Gallisepticum Infection In Eastern Bluebirds (Sialia Sialis), Sarah Danielle Amonett

Electronic Theses and Dissertations

Parents can transmit pathogens to their offspring. Neonatal hosts are particularly vulnerable to infectious diseases, as they have immature adaptive immune systems at birth. In this study, I examine parental transmission of a combacterial pathogen Mycoplasma gallisepticum (MG) in wild eastern bluebirds (Sialia sialis) and its impact on nestling growth. By diagnosing infections in all family members, I confirmed that eastern bluebird nestlings can contract MG infections, and that infection was more comin older nestlings compared to adults and neonates. Furthermore, unlike in other avian hosts, MG infection does not significantly impact nestling body condition. In response to infection, eastern …

Utilization Of A Community Pharmacy-Based Service For The Treatment Of Uncomplicated Urinary Tract Infections In Scotland, Robert Borchardt

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Introduction: In November 2013, Scotland piloted a program in Grampian for the treatment of Urinary Tract Infections (UTIs) in community pharmacies, increasing health access for patients and reducing general practitioner workload. This program became known as ‘Pharmacy First’ and was later implemented nationwide in November 2017. This paper seeks to understand utilization of the Pharmacy First program across Scotland by patients and potential barriers to access.

Methods: Using data from the Prescribing Information System collected by the National Health Service of Scotland from July 2013 to April 2019, orders for uncomplicated UTIs were gathered by examining all nitrofurantoin and trimethoprim …

Dalbavancin In The Community Emergency Department, Wesley Johnson

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Introduction

Dalbavancin is an antibiotic within the class of medications known as lipoglycopeptides. This medication is given to patients presenting to the hospital with acute skin and skin-structure infections (ABSSSI). This is a unique medication because it is given as a one-time dose in the outpatient setting and it could prevent patients from requiring admission to the hospital.

Methods

The emergency department (ED) at Good Samaritan community hospital performed a trial period with dalbavancin and data was collected from November 2018 to March 2020. Retrospective chart review was performed to obtain patient data and outcomes. Patients would be contacted by …

The Role Of Feed Additives In Mitigating The Effect Of Stressors On Growth, Digestibility, Intestinal Morphology, Permeability, And Immune Response In Poultry, Yemi Olojede Burden

Theses and Dissertations--Animal and Food Sciences

Three experiments were conducted to evaluate the interactive effects of dietary supplements in birds exposed to different stressors, on growth performance, nutrient, and energy digestibility, antioxidant status, intestinal permeability, and immune status. The first study was conducted to evaluate the effect of a commercially available algae-based antioxidant, containing Selenium yeast (EconomasE™, EcoE) and two inorganic sodium sources (NaCl and NaCl+NaHCO3) on growth performance, nutrient and energy digestibility and utilization, antioxidant, and immune status of broilers challenged with oral gavage of dexamethasone (DEX). The inclusion of either of the sodium sources did not affect plasma corticosterone and antioxidant status levels, growth …

Who Infant And Young Child Feeding Indicators In Relation To Anthropometric Measurements, Abdullah Al-Taiar, Nawal Alqaoud, Majeda S. Hammoud, Faheema Alanezi, Nawal Aldalmani, Monica Subhakaran

Community & Environmental Health Faculty Publications

Objective: This study aimed to report the WHO infant and young child feeding (IYCF) indicators from Kuwait and to investigate the associations between these indicators and anthropometric measurements.

Design: The Kuwait Nutritional Surveillance System uses observational cross-sectional approach to collects data by face-to-face interviews with mothers or child guardians using a structured questionnaire that was developed based on the WHO IYCF indicators. The weight and height of infants and young children were measured using digital scales in a standardised manner.

Setting: Vaccination centres in all governorates (provinces) of Kuwait.

Participants: Infants and young Kuwaiti children aged 0–23 months (N 5839). …

The Living Community Challenge: An Uncase Study In Biophilic Master Planning, Jordan Grimaldi

Pomona Senior Theses

In a world that is quickly urbanizing with a climate that is rapidly changing, the International Living Future Institute’s (ILFI) Living Community Challenge (LCC) offers a whimsical yet highly relevant model for sustainable development—creating cities that are as connected and beautiful as forests. As no certified Living Community exists yet, this thesis serves as an “uncase study” of North Rainier, a neighborhood in Seattle that has registered for the Challenge. In an effort to assess the LCC’s perceived effectiveness as a model for sustainable development, this thesis first summarizes nearly 400 centuries of U.S. developmental history to give greater context …