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[Discussions] Vol. 20 Iss. 2

Discussions

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Navigating The Shadows: Exploring The Interaction Between Social Progress And The Shadow Economy, Aziz N. Berdiev, James W. Saunoris

Mathematics and Economics Faculty Journal Articles

This paper uniquely examines the noneconomic dimensions of a nation’s overall wellbeing by focusing on social progress and its impact on the shadow economy. The shadow economy serves an important function in a market economy bysupplying goods and services that meet the social demands of society. We argue that deficits in social development, or social regression, prompt the expansion of the shadow economy. Employing cross-country panel data for 124 countries from 1991 to 2017 and two-way fixed effects instrumental variables estimation, the results show that advancements in social progress reduce the size of the underground sector. In terms of magnitude, …

Metabolic And Microbial Crossroads: Sodium-Glucose Cotransporter-2 Inhibitors And Urinary Tract Infections In (Asian) Diabetes Care, Rob E. Carpenter

Human Resource Development Faculty Publications and Presentations

The global rise of type 2 diabetes, particularly in Asian populations, has led to widespread adoption of sodium-glucose cotransporter-2 (SGLT2) inhibitors for glycemic control. While effective, these agents elevate the risk of urinary tract infections (UTIs) by inducing glycosuria, which creates a nutrient-rich environment that favors uropathogen growth. Asian individuals may be disproportionately vulnerable to SGLT2 inhibitor–associated UTIs due to a confluence of factors, including lower body mass index, increased visceral adiposity, congenital urinary tract anomalies, and genetic polymorphisms that impair uroepithelial integrity and immunity. This review integrates emerging evidence on the molecular, anatomical, and immunometabolic mechanisms that underlie infection …

Low Serum Alkaline Phosphatase Concentrations At Hospital Admission As Markers For Severe Pediatric Sars-Cov-2-Related Acute Illnesses, Sneha Jayadeep, Julie A. George, Bishara J. Freij

Conference Presentation Abstracts

Background: Alkaline phosphatase (ALP) is composed of several isoenzymes. The measured serum (total) ALP is mostly of bone and liver origin. ALP activity changes with growth and puberty, and its level is affected by age and sex. Abnormal ALP levels have been noted in COVID19 patients but its use as a marker of severity has not been assessed to our knowledge.

Objective: Assess if low serum ALP is a marker of disease severity in acute Pediatric SARS-CoV-2-related illnesses.

Design/Methods: Retrospective observational study of children 0-18 years of age hospitalized at Beaumont Children’s Hospital from 3/1/2020-3/31/2022 with positive PCR for SARS-CoV-2 …

The Impact Of Epac2-Associated Junction Plakoglobin On Respiratory Syncytial Virus Infection, Chaitra A Takle, Eun-Jin Choi, Eun Seok Choi, Devang Deepak, Kashish Khatkar, Jong Min Choi, Ke Zhang, Sung Yun Jung, Tian Wang, Wenzhe Wu, Xiaoyong Bao

Faculty, Staff and Students Publications

Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in infants, young children, and immunocompromised individuals. Currently, FDA-approved monoclonal antibody therapies are limited to infants and young children with severe RSV disease. As a result, there is an urgent need for comprehensive studies of RSV pathogenesis to support the development of new therapeutic strategies. Exchange proteins directly activated by cAMP (EPAC) have recently emerged as key regulators in various viral infections. Our previous work identified EPAC isoform 2 (EPAC2) as a critical factor in RSV replication and host innate immune responses. However, …

Optimization Of Reaction Conditions For Synthesizing Kasa-Targeting Drug Candidates For Tuberculosis Treatment, Megan A. Baxter

Research and Creativity Symposium

Tuberculosis (TB) remains a global health challenge, with increasing drug resistance pressing for the development of novel treatments. KasA, a key enzyme in mycobacterial fatty acid biosynthesis, is a promising drug target for TB treatment. This research focuses on the design and synthesis of potential KasA inhibitors, specifically optimizing reaction conditions to efficiently produce 1-methyl-6-aminoindazole. This molecule is an intermediate in the synthesis of drugs targeting TB. Characterization of synthesized compounds is performed using NMR, mass spectrometry, and gas chromatography to confirm structure and purity. The first step involved optimizing the solvent and base for the methylation of nitroindazole. We …

From Dysbiosis To Dysfunction: Investigating The Effects Of Chronic Cocaine Use On Oral Microbial Shifts And Neuropathogenesis, Douglas E. Johnson

MUSC Theses and Dissertations

Cocaine use disorder remains a significant public health challenge. However, the mechanisms by which chronic cocaine use contributes to neuroinflammation and cognitive decline are still not fully understood. Chronic non-intravenous cocaine use is associated with oral microbial dysbiosis. Although the gut-brain axis has been widely studied, the impact of cocaine-mediated shifts on the oral microbiome on systemic and neuroinflammation remains a significant yet largely unexplored gap. This dissertation investigates the hypothesis that cocaine-specifically enriched oral Streptococcus parasanguinis triggers neuroinflammation, neuropathology, and cognitive deficits. In a human study, the saliva microbiomes from chronic cocaine users exhibited reduced α-diversity, enriched Streptococcus genus, …

Reducing Antibiotic Duration For Pneumonia And Sinusitis In The Emergency Department: A Quality Improvement Approach, Joshua Saucedo, Leslie Hueschen, Amanda Nedved, Marsha Dannenburg, Patricia Phillips, Jennifer Floyd, Alaina N. Burns, Rana El Feghaly

Presentations

Background: Limiting antibiotic duration is one of the pillars of antimicrobial stewardship programs (ASP) as it reduces unnecessary antibiotic exposure. In our emergency department (ED), >90% of respiratory infections are treated with first-line guideline-recommended antibiotics; however, duration continues to be prolonged especially for community acquired pneumonia (CAP) and acute bacterial rhinosinusitis (ABRS). Institutional guidance recommends shortening antibiotic durations to 3-5 days for CAP and 5-7 days for ABRS, however only 13% of discharged ED patients receive the recommended duration. Objective: Our aim is to increase the percentage of children discharged home from the ED with a diagnosis of CAP or …

Spectrum Of Congenital Anomalies Detected Through Anatomy Ultrasound At A Referral Hospital In Ghana, Alim Swarray-Deen, Morgan Yapundich, Sarah Boudova, Kwaku Doffour-Dapaah, Jeff Osei-Agyapong, Perez Sepenu, Alex K. Boateng, Teresa A. Mensah, Patrick Anum, Nana Essuman Oduro, Theophilus Adu-Bredu, Promise E. Sefogah, Jerry Coleman, Samuel A. Oppong

Department of Obstetrics and Gynecology Faculty Papers

BACKGROUND: Africa has a high burden of congenital anomalies due in part to limited preconception care, infections, and environmental exposures. However, the true prevalence of congenital anomalies is unclear because of insufficient access to prenatal diagnostic services. We aimed to determine the rate of congenital anomalies, and characterize the anomalies detected prenatally at a referral hospital in Ghana.

METHODS: We performed a four-year retrospective review of all fetal anomaly ultrasounds performed and congenital anomalies detected from January 1st, 2020, to December 31st, 2023, at Korle Bu Teaching Hospital, Accra, Ghana. Data were extracted from the electronic database on maternal age, …

Factors Associated With Quality Of Intrapartum Care In Kenya: A Complex Samples Analysis Of The 2022 Kenya Demographic And Health Survey, Lilian Nuwabaine, Earnest Amwiine, Quraish Sserwanja, Joseph Kawuki, Mathius Amperiize, Angella Namulema, Ahmed Sarki, John Baptist Asiimwe

School of Nursing & Midwifery, East Africa

Background

The provision of quality intrapartum care increases women’s utilization of skilled birth attendants in health facilities and improves maternal and newborn health. This study aimed to investigate the factors associated with the quality of intrapartum care using the 2022 Kenya Demographic and Health Survey (KDHS).

Methods

Secondary data from the 2022 KDHS of 11,863 participants, who were selected by multistage stratified sampling, was used. Based on literature and the availability of indicators within the 2022 KDHS, the quality of intrapartum care was operationalized as receiving all the three clinical components of intrapartum care including a mother having a facility-based …

Bio-Physiological Development During Adulthood, Maria Boix Braga, Charles J. Golden, Lisa K. Lashley

Essays in Developmental Psychology

Defining adulthood, and what the criteria truly is to be able to consider oneself an adult, varies from culture to culture. Biologically, adulthood can also be defined as the period in which full physical and intellectual maturity has been attained. It is a period that is defined slightly differently depending on the source, but it is agreed that it tends to be considered the life period between ages 18 and 60. However, the definition of adulthood can have varying legal and sociocultural factors as well. For example, the legal definition of an adult is a person who has reached the …

Synergetic Effects Of Spironolactone And Dehydro-Cortistatin A On Hiv Suppression, Alexander Lopez

Harriet L Wilkes Honors College Theses 2020 - Present

HIV remains a significant challenge due to its ability to establish latent reservoirs in CD4+ T cells, requiring lifelong antiretroviral therapy (ART). As part of the general effort to find a functional cure for HIV, this study investigated the effects of spironolactone (SP) and dehydro-cortistatin A (dCA) on HIV expression, both individually and in combination, using J-Lat 10.6 cell models. Cells were treated with SP (10 μM), dCA (20 nM), and a combination of both drugs in a longitudinal study, with samples collected at multiple time points. Results indicate that both SP and dCA individually suppress HIV expression compared to …

Evaluating The Causal Effect Of Receiving Transthoracic Echocardiography On 28-Day Mortality In Mimic-Iii Intensive Care Unit Patients With Sepsis, Monserrath Velez, Jack O'Connor, Nicholas Della Pesca, Rio Baliga

Research & Creative Achievement Day

❏ Sepsis (an infection associated with vital organ dysfunction) is an emergent

medical condition estimated to occur in about 30% of intensive care unit

(ICU) patients[1] and is responsible for 20% of all deaths worldwide[2]

❏ Transthoracic echocardiography (TTE; an imaging modality that uses

ultrasound technology to record heart structure and function) is widely used in

medical treatment [3]

❏ 28-day mortality (whether or not a patient dies within 28 days after receiving a

treatment) is a measure considered to closely approximate ICU mortality[4]

Objectives

❏ Assess and quantify the causal effect of receiving a TTE on …

Investigating Genetic Regulators Of Crystal Cell Development In Drosophila Melanogaster, Andrea Feria, Nyla Walbrook, Anisa Turaeva, Rebecca Spokony

Publications and Research

Crystal cells, a subset of Drosophila melanogaster hemocytes, are important for melanization, a crucial immune response. While the genetic regulation of crystal cell develop remains incompletely understood, this study investigates the functions of five candidate genes: ACXB, ACXA, Gp210, CG4390, and Cyp4s3; identidied through previous genome-wide association studies. Using the Gal4/UAS system along with RNA interference (RNAi), we exclusively knocked down each gene in third instar larvae and quantified crystal cell populations following heat shock-induced melanization. Our results imply that the knockdown of ACXB and ACXA significantly increased crystal cell counts in both sexes, suggesting these genes either act as …

The Impact Of Social Determinants Of Health On Nicaraguan Immigrants In Costa Rica, Callie Stillion

Symposium on Research and Creative Expression (SORCE)

During Valparaiso University's annual service learning trip to Costa Rica in March 2024, five public health clinics were conducted in the communities of La Carpio, Boca Arenal, and San Gerardo, which held a combined population of approximately 69,000 at the time, most of which were Nicaraguan immigrants. These clinics were led by students and translators, small groups of which were sent out each day to conduct home visits within these neighborhoods to gather qualitative and quantitative data, including demographic information, details about the home environment, health insurance status, reasons for immigrating to Costa Rica, and perception of health threats from …

Discovering New Plant-Based Compounds To Treat Oral Diseases: An Independent Research Project, Daileen Serrano, Jenna Yehyawi, Danielle Orozco-Nunnelly, Jeffrey Pruet

Symposium on Research and Creative Expression (SORCE)

Infectious diseases are cited as one of the main causes of death worldwide. Many drugs to treat such illnesses were discovered in the mid-1900s, but this type of research has declined in recent years. At the same time, antimicrobial-resistant “superbug” infections are on the rise, including superbug biofilms present in the oral cavity, which are responsible for diseases such as tooth decay, gum disease, and implant failure. Therefore, I have been working to explore various plants from a medicinal garden on the Valparaiso University campus to screen extracts against common disease-causing oral bacteria with the goal of discovering novel compounds …

Probing Medicinal Plants For Novel Antimicrobial Compounds, Edgar Padilla, Sabrina Ezell, Leah Streetman, Nolan Brezina

Symposium on Research and Creative Expression (SORCE)

According to the W.H.O., infectious diseases account for three of the top ten global causes of death. Antimicrobial drug discovery surged in the mid-twentieth century but has sharply declined in recent years. At the same time, antimicrobial-resistant “superbug” infections are on the rise. Plants produce a robust array of novel metabolic compounds including many antimicrobial agents. However, with the advent of modern antibiotic drugs, natural plant-derived antibiotic sources have largely been left unexplored. Therefore, our work focuses on screening under explored medicinal plants in hopes of discovering novel antimicrobial drugs. To accomplish this, we have been testing extracts of plants …

“We Live In A Spiritual Country”: The Associations Among Health Literacy, Quality Of Life, And Religious Spiritual Personal Beliefs Among The Nigerian Population, Rebecca Aderoju

Electronic Theses and Dissertations Archive

This dissertation examines the complex interplay between health literacy (HL), quality of life (QoL), and spiritual and religious beliefs (SRPB) among underserved populations in Nigeria. Despite increasing awareness of healthcare options, many Nigerians continue to rely on faith-based healing practices due to deeply rooted religious and cultural traditions, economic barriers, and systemic healthcare limitations. Using a mixed-methods approach, this research incorporates both survey data and focus group discussions to investigate the relationship that Nigerians make among these variables. This study employs the Social Ecological Model (SEM) to explore how individual, interpersonal, community, organizational, and policy factors shape health behaviors and …

Passive Integrated Transponders: An Effective Marking Technique For Individual Identification Of Anaxyrus Fowleri?, Emily Leprell

Honors College Theses

With the rise of fungal disease such as Chytridiomycosis, known as chytrid, causing massive population declines for many species of frogs and toads (order Anura), specific conservation strategies are needed now more than ever. In many cases, being able to mark and identify individuals is a necessary step in developing an effective conservation plan. Individual identification allows researchers to obtain accurate population estimates, which are needed to test the progress and validity of conservation management decisions. However, due to their unique life history, including cutaneous respiration and a dichotomous lifestyle, anurans are among the most difficult wildlife species to …

254 - “Ship Fever”: Contextualizing Epidemic Typhus In Mid-19th Century New York, Audrey Ryan

GREAT Day Posters

Epidemic typhus is a disease caused by the bacteria R. prowazekii, and spread through the vector of human body lice. Historically, typhus outbreaks have been associated with “social maladies”: poverty, war, natural disasters, and other factors that bring about the overcrowded and unhygienic living conditions where typhus spreads most easily. In a study I conducted last year, I learned that between 1847 and 1850, 17.5% of the 169 adult deaths in the Monroe County Poorhouse were attributed to typhus (also called “ship fever”). In a sample of 205 people buried in Mount Hope Cemetery (Rochester's general population) during the same …

Estimating Disease Transmissions With Assortative Mixing By Vaccination Status, Jacob D. Biesecker-Mast

Honors Theses

Many mathematical models of infectious disease assume the population is well-mixed, meaning every pair of individuals is equally likely to contact each other, potentially spreading the disease. In reality, populations are rarely well-mixed, and an important way in which they are not is assortative mixing, that is, when pairs of individuals who are similar are more likely to contact one another than pairs of individuals who are different. Failing to account for assortative mixing by vaccine status leads to biased estimates of important quantities that characterize disease transmission, including reproduction numbers. We expand on this by developing a model that …

244 - Trends And Practices Relating To Maternal Mortality Rates In 19th And Early 20th Century Rochester, New York, Shannon Lacy

GREAT Day Posters

This study explores the incidence and causes of maternal mortality in 19th century and early 20th century Rochester. Several practices, including the emergence of antiseptics and obstetrics, have reduced maternal mortality rates since the end of the 19th century. At that time, the development of germ theory led to the discovery of the cause of puerperal fever, a common cause of maternal deaths first addressed by Semmelweis in the 1840s. Although the overall prevalence of sepsis-related post-birth mortality has decreased, we are now seeing how the medicalization of birth comes with its own complications, including hemorrhage and post-intervention infection. In …

The Leading Causes Of Homelessness In Two Southeastern Counties Of Pennsylvania, Lucia Christine Spargo

Walden Dissertations and Doctoral Studies

Homelessness is a complex and multifaceted leading social issue in the United States. Society tends to focus on the individual as the cause of their own homelessness, blaming the victim rather than larger social and/or economic factors. There is an excess amount of data surrounding why/how an individual becomes homeless, but there is very little research examining the leading causes of homelessness in smaller geographic areas, such as counties. This study provides a better understanding and analysis of the leading causes of homelessness in two suburban counties in Southeastern Pennsylvania using binary logistic regression. Using ArcGIS, the study identified potential …

Demography Of Bluff View Cemetery Vermillion, Sd, Ellie E. Schwartz

Honors Thesis

Cemeteries offer accessible, rich data for research on demographic reconstruction of past populations. Gravestones can give vital information such as date of birth, date of death, sex/gender, occupation, religious affiliation, and, implicitly, social and cultural values of the community at large (Dethlefsen and Deetz, 1966; Sattenspiel and Stoops, 2010). One of the drawbacks of cemetery data are that they more often than not do not provide details of the cause of death for an individual or in some rare occasions cause of death is on the gravestones (e.g., colonial graves during the tuberculosis outbreak in New England would often list …

Safety And Efficacy Of Single-Dose Primaquine To Interrupt Plasmodium Falciparum Malaria Transmission In Children Compared With Adults: A Systematic Review And Individual Patient Data Meta-Analysis, Wwarn Paediatric Primaquine For P Falciparum Transmission Blocking Study Group, Daniel Yilma, Kasia Stepniewska, Teun Bousema, Chris Drakeley, Prashanti Eachempati, Philippe J. Guerin, Andreas Mårtensson, Richard Mwaiswelo, Walter R. Taylor, Karen I. Barnes

Peninsula Dental School

Background: Adding a single dose of primaquine to artemisinin-based combination therapy (ACT) for the treatment of falciparum malaria can reduce the transmission of Plasmodium falciparum and could limit the spread of artemisinin partial resistance, including in Africa, where the disease burden is greatest. We aimed to compare the safety and efficacy of single-dose primaquine plus ACT between young children (aged <5 years) and older children (aged 5 years to <15 years) and adults (aged ≥15 years), and between low and moderate-to-high transmission areas. Methods: For this systematic review and individual patient data meta-analysis, we searched PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, WHO Global Index Medicus, OpenGrey.eu, ClinicalTrials.gov, and the WHO International Clinical Trials Registry Platform, from database inception to April 3, 2024, with no language restrictions. We included prospective studies on efficacy against falciparum malaria that enrolled at least one child younger than 15 years and involved a study group given a single dose of primaquine (≤0·75 mg/kg) plus ACT. Studies involving mass drug administration, healthy volunteers, or patients with severe malaria or mixed (with non-falciparum) infections were excluded. For inclusion in the efficacy analysis, data on transmission potential (as determined by gametocytaemia, infectivity, or both) at enrolment and follow-up (day 3, day 7, or day 14) were required; the safety analysis required data on haemoglobin concentrations or haematocrit values at enrolment and at one or more follow-up visits by day 7, any data on adverse events, or both. After independent screening of the search results by two reviewers, the investigators of eligible studies were invited to contribute individual patient data. We quantified day 7 gametocyte carriage, probability of infecting a mosquito, decreases (>25%) in haemoglobin concentration associated with anaemia, and adverse events until day 28 using regression analyses, with random study-site intercepts to account for clustered data. These analyses were registered with PROSPERO, CRD42021279363 (safety) and CRD42021279369 (efficacy). Findings: Of 5697 records …

Use Of Procalcitonin In Therapeutic Decisions In The Pediatric Intensive Care Unit, Pierre Tissières, Elisabeth Esteban Torné, Johannes Hübner, Adrienne Randolph, Corsino Rey Galán, Scott Weiss

Department of Medicine Faculty Papers

Procalcitonin (PCT) is frequently used by clinicians in children with suspected bacterial infections and sepsis. However interpretation in the critically ill child may be challenging due to the complexity of underlying conditions and its impact on PCT values. Herein, we propose a guidance for the use of procalcitonin in critically ill children, supported by a comprehensive analysis of the literature, to help the clinician for interpreting PCT in the various clinical conditions encountered in pediatric intensive care units. We describe the importance of the clinical context, timing of measurement and evidence on PCT values in diagnosing sepsis and to guide …

A Review Of Complimentary Theoretical Lens: Managing Supply Chain Of Material Drugs In Sub-Saharan Africa, Pross Oluka Nagitta, Godwin Kwemarira, Joseph Bufwambu, Luke Sewante, Bridget Nambuiru

African Social Science Review

The study examines supply chain coordination of the distribution of Artemisinin-based Combination Therapies (ACTs)intended for the treatment of malaria in Africa. Uganda, like most countries in Sub-Saharan Africa, lacks effective coordination structures to facilitate the delivery of ACTs. Thus, the researchers attempt to explain supply chain coordination using the activity domain, resource dependency, and coordination theories. This study builds upon previous studies that have used complexity theory and transaction cost economies perspectives to inform supply chain coordination. The article answers the following questions: What theories can be used to understand supply chain coordination in Sub-Saharan Africa? What opportunities does this …

Intervention To Increase Uptake Of Cervical Screening In Norfolk City, Frederick Kankam Adu

Graduate Student Government Association Research Conference

The Objective is to determine the impact free screening and education to females between the ages 21 to 64 years, or under 21 years who are sexually active and unvaccinated against HPV virus have on uptake of cervical screening. In this study we use Before and After study design. The Outcomes for cervical screening are categorized as negative, atypical squamous cells undetermined significance( ASCUS), low-grade squamous intraepithelial lesion( LGSIL), high-grade squamous intraepithelial lesion(HGSIL), unsatisfactory samples, and HPV positive. Colposcopy will be performed if abnormal pap-smear is found. And outcomes of colposcopies, after abnormal Pap tests will be classified as negative( …

Evaluation Of Shorter Versus Longer Antifungal Treatment Durations For Candida Spp. Urinary Tract Infections Among Hospitalized Adults., Jacob C. Govel, Robert W. Seabury, Elizabeth A. Asiago-Reddy, Ramiro L. Gutierrez, Katie A. Parsels, Wesley D. Kufel

Pharmacy Faculty Scholarship

Infectious Diseases Society of America guidelines recommend 14 days of treatment for Candida spp. urinary tract infections (UTIs). To our knowledge, no data are available to compare <14 days for Candida spp. UTI. This was a>single-center, retrospective cohort study between 01 January 2015 and 01 January 2024. Hospitalized adults with >1 urine culture with Candida spp. and symptoms who initiated >1 antifungal dose within 96 hours were included. Multiple exclusion criteria existed, including but not limited to if Candida spp. were isolated from another site, antifungals were received for another indication, or the participant was asymptomatic. The primary outcome was clinical treatment success. Binary logistic regression was performed …

Unique Stress, Cultural Resources, And Psychological Resilience In Young African American Women: Insights For Effective Intervention And Cvd Prevention, Sparkle Springfield-Trice, Cara Joyce, Penny Williams-Wolford, Dinishia Wolford, Destiny Onyeise, Natalie Battles, Dionne V. Milton, Chineze Mogbo, Raigine Robinson, Dave Stovall, Lena Hatchett, Ursula M. Staudinger

Biostatistics Collaborative Core: Faculty Publications and Other Works

Objective: Psychological resilience, defined as one’s self-reported ability to bounce back from stress, is understudied in young African American women (YAAW). Guided by community feedback, this study examined the associations between resilience and the following three constructs from Staudinger’s 2015 resilience and aging model: perceived stress, non-psychological resources, and psychological resources. We aimed to identify cultural resources that can enhance resilience in the face of unique stressors.

Methods: A cross-sectional survey was administered to 512 self-identified YAAW aged 18–35 years. Resilience was measured by the Brief Resilience Scale, ranging from one to five, with higher scores indicating greater resilience. We …