Digital Commons Network^™

Mutational Analysis And Domain Characterization Of The Apolipoprotein L-1 Ion Channel, Charles M. Schaub

Dissertations, Theses, and Capstone Projects

The human innate immunity factor Apolipoprotein L-1 (APOL1) protects against Trypanosoma brucei brucei infection. Recent studies have shown recombinant APOL1 (rAPOL1) inserts into planar lipid bilayers at an acidic pH 5.6 and forms a cation-selective channel, which opens upon subsequent neutralization, pH 7.2. This corresponds with the pH changes APOL1 would encounter during endosome recycling, suggesting that APOL1 forms a pH-gated ion channel in the plasma membrane of the parasite, leading to uncontrolled ion flux and osmotic imbalance. However, structural and domain characteristics of the APOL1 channel are poorly understood, despite potential similarities to diphtheria and colicin toxins. Utilizing E. …

Research Output On Acupuncture Research Across The Globe: A Scientometric Assessment On Web Of Science Database, Prakash M

Library Philosophy and Practice (e-journal)

No abstract provided.

Sick Buildings, Poor Design And Public Heath, Dalia Shebl Said, Yasmin Shebl Said

Architecture and Planning Journal (APJ)

There is no doubt that there is a close relationship between health problems and housing conditions. According to the World Health Organization (WHO) estimates in developing countries those 2 million early and unexpected deaths, with close to half occurring among children less than 5 years old die from indoor air pollution and bad housing. Housing is an important determinant of health, and substandard housing is a major public health issue. Designing and bad orientation of housing are found to have significant effects on poor respiratory health especially in children, and increase an infectious disease thereby putting them at higher risk …

Uab Infectious Disease Experts Address Novel Coronavirus, Adam Pope

Browse All News

No abstract provided.

Humanized Nog Mice For Intravaginal Hiv Exposure And Treatment Of Hiv Infection, Anna Halling Folkmar Andersen, Stine Sofie Frank Nielsen, Rikka Olesen, Katharine Mack, Frederik Dagnæs-Hansen, N. Uldbjerg, Lars Østergaard, Ole S. Søgaard, Paul Denton, Martin Tolstrup

Biology Faculty Publications

Humanized mice provide a sophisticated platform to study human immunodeficiency virus (HIV) virology and to test antiviral drugs. This protocol describes the establishment of a human immune system in adult NOG mice. Here, we explain all the practical steps from isolation of umbilical cord blood derived human CD34+ cells and their subsequent intravenous transplantation into the mice, to the manipulation of the model through HIV infection, combination antiretroviral therapy (cART), and blood sampling. Approximately 75,000 hCD34+ cells are injected intravenously into the mice and the level of human chimerism, also known as humanization, in the peripheral blood is estimated longitudinally …

Covid-19 As A Non-Traditional Threat To Human Security, Siti Nurhasanah, Marthen Napang, Syaiful Rohman

Journal of Strategic and Global Studies

December 2019 marks a change in the perception of security itself because the enemy is invisible in the form of a virus that can endanger human survival. In this article, the author wants to discuss changes in the perception of "threat" in security from a "visible" threat to an "invisible" threat. Library research was used by the author in this article. The author uses three concepts as the development of security, namely traditional security concept, non-traditional security concept, and national security concept to analyze the case. The findings show that invisible threat in the form of virus or pandemic does …

Rainfall, Precipitation, And Drought Patterns Associated With Wintertime Transmission Of Eastern Equine Encephalitis Virus (Eeev) In Florida, Bestami Cevher

USF Tampa Graduate Theses and Dissertations

Eastern Equine encephalitis virus (EEEV) is a highly pathogenic alphavirus that causes disease in humans and horses. EEEV cases are common in the eastern North America, especially in horses in the State of Florida. EEEV cases are most common in Florida during May to August but also occur year-round, unlike most other locations. According to the Florida Department of Health, 65 EEEV horse cases were documented in the winter months between 2005 and 2018. This study investigates the meteorological activities that affect the wintertime transmission of the EEEV virus to horses. In this, we examined meteorological data up to a …

Immunization Training Modules: Identifying Student Nurse Learning, Katie Bates

Theses and Dissertations

Background: Despite the importance of vaccination in disease prevention some people choose to remain unvaccinated. Nurses are influential in the choice to vaccinate. Considering the possibility of poor public understanding of vaccines and need for continued improvement in vaccination rates, it is essential for nurses to be knowledgeable and adept at addressing vaccine concerns. Vaccination education formally begins in nursing school. Objective: To identify nursing students' vaccine understanding by exploring information learned from formal online vaccine education specifically the Nursing Initiative Promoting Immunization Training Modules (NIP-IT). Design/Setting/Participants/Methods: Nursing students enrolled in a Community Health Nursing course were required to complete …

Pollution Control Can Help Mitigate Future Climate Change Impact On European Grayling In The Uk, J. Vanessa Huml, W. Edwin Harris, Martin I. Taylor, Robin Sen, Christel Prudhomme, Jonathan S. Ellis

School of Biological and Marine Sciences

No abstract provided.

Scientometric Analysis On Scholarly Communications Of National Institute Of Mental Health And Neurosciences (Nimhans), India, Radhakrishnan Natarajan, Prabahar Ponniah Mr.

Library Philosophy and Practice (e-journal)

The study investigated the research publications of the National Institute of Mental Health and Neurosciences (NIMHANS) during the period 2009-2018 as reflected in Web of Science database. The results show that 1694 papers were published and gained 20158 citations. The average number of citations per paper identified is 11.89%. Neuroscience Neurology, Psychiatry, and Surgery are the most preferred domains to publish the articles. The global collaboration of NIMHANS is mostly with the USA, England, and Australia. The degree of collaboration is 0.99. The researchers of NIMHANS prefer to publish their papers in Indian journals. Lotka's law was tested to measure …

Hadron, Caitlyn Castillo '20

Hadron Magazine

• Pg 7 : Artificial Intelligence in Healthcare
• Pg 8 : Possible Treatments of Respiratory Diseases in Infants
• Pg 11 : Black Holes Suppress the Growth of Dwarf Galaxies
• Pg 12 : DARPA Funded Gene Modulation, the New Genetic Medicine?
• Pg 14 : Biomarkers of Chronic Pain
• Pg 16 : How Regenerative Medicine is Leading to Discoveries
• Pg 18 : Interview on the new 'Rhetoric and Communications' Course
• Pg 21 : Mathematical Epidemiology
• Pg 22 : The 'Quantum Zeno Effect' Explained
• Pg 24 : References

Myxobacterial Response To Methyljasmonate Exposure Indicates Contribution To Plant Recruitment Of Micropredators, Barbara I. Adaikpoh, Shukria Akbar, Hanan Albataineh, Sandeep K. Misra, Joshua S. Sharp, D. Cole Stevens

Faculty and Student Publications

© Copyright © 2020 Adaikpoh, Akbar, Albataineh, Misra, Sharp and Stevens. Chemical exchanges between plants and microbes within rhizobiomes are critical to the development of community structure. Volatile root exudates such as the phytohormone methyljasmonate (MeJA) contribute to various plant stress responses and have been implicated to play a role in the maintenance of microbial communities. Myxobacteria are competent predators of plant pathogens and are generally considered beneficial to rhizobiomes. While plant recruitment of myxobacteria to stave off pathogens has been suggested, no involved chemical signaling processes are known. Herein we expose predatory myxobacteria to MeJA and employ untargeted mass …

Wise Blood: The Principle Of Overcoming In Disease And Immunity (Part 1), Alan L. Gillen, Keoprommony Huy

Faculty Publications and Presentations

The immune system is an intelligently made system designed for interaction with microbes even in a perfect world; it is more than a defense. However, in a post-fall world, it is primarily a body’s defense system. Battle imagery is appropriate for describing the interaction with pathogens and parasites. A person’s blood becomes more potent over time as that person prevails and overcomes pathogens and parasites with its newly formed antibodies in high numbers. Antibodies have the secret locked away to defeat the germ that has invaded. The second infection usually has minimal harm; hence, the “wise” blood is more likely …

10th Annual Postdoctoral Science Symposium, University Of Texas Md Anderson Cancer Center Postdoctoral Association

Annual Postdoctoral Science Symposium Abstracts

The Annual Postdoctoral Science Symposium (APSS) was initiated on August 4, 2011, by the MD Anderson Postdoctoral Association to provide a platform for talented postdoctoral fellows throughout the Texas Medical Center to present their work to a wider audience.

APSS is a scientific symposium organized by postdoctoral fellows from The University of Texas MD Anderson Cancer Center that welcomes submissions and presentations from postdoctoral fellows from all Texas Medical Center affiliated institutions and other Houston area institutions. The APSS provides a professional venue for postdoctoral scientists to develop, clarify and refine their research as result of formal reviews and critiques …

Identification Of Ebsulfur Analogues With Broad-Spectrum Antifungal Activity, Sylvie Garneau-Tsodikova, Huy X. Ngo, Sanjib K. Shrestha

Pharmaceutical Sciences Faculty Patents

The invention relates to novel ebsulfur analogues and novel pharmaceutical compositions comprising ebsulfur analogues. The invention also relates to novel methods of treating infections caused by fungal species comprising administration of ebselen, ebsulfur, and ebsulfur analogues.

Phylogenetic Afficity Of Genolopa (Digenea: Monorchiidae) With Descriptions Of Two New Species, Apryle J. Panyi, Stephen S. Curran, Robin M. Overstreet

Faculty Publications

The validity of Genolopa Linton, 1910 has been controversial because the observation of presently recognized critical diagnostic morphological features (spines in the genital atrium and a bipartite, anteriorly spined terminal organ) were omitted from the original diagnosis, and these features were not universally appreciated as important diagnostic features until 2008. Modern taxonomists have been further challenged by inappropriate fixation techniques that have resulted in various interpretations of morphological features. Consequently, named species in the genus have fluctuated among other monorchiid genera depending on various interpretations by taxonomists, and a modern consensus on classifying these species is lacking. This study …

Independent - Jan. 28, 2020, Frannie Mendoza

The Independent (1988-present)

No abstract provided.

The Current Volume 30 : Issue 18, Nova Southeastern University

Student Newspapers

No abstract provided.

Multicenter Evaluation Of The New Etest Gradient Diffusion Method For Piperacillin-Tazobactam Susceptibility Testing Of Enterobacterales, Pseudomonas Aeruginosa, And Acinetobacter Baumannii Complex, Sergio García-Fernández, Yohann Bala, Tom Armstrong, María García-Castillo, Carey-Ann D. Burnham, Meghan A Wallace, Dwight Hardy, Gilles Zambardi, Rafael Cantón

Open Access Publications

Piperacillin-tazobactam (P/T) is a β-lactam-β-lactamase inhibitor combination frequently used in the hospital setting. Etest is a gradient diffusion method that represents an alternative to broth microdilution (BMD) for performing antimicrobial susceptibility testing. We conducted a multicenter evaluation of the performance of the new P/T Etest compared to that of BMD following U.S. Food and Drug Administration (FDA) and International Standards Organization (ISO) standard ISO 20776-2 criteria using Clinical and Laboratory Standards Institute (CLSI)-FDA and European Committee on Antimicrobial Susceptibility Testing (EUCAST) interpretive breakpoints, respectively. A total of 977 isolates (775

A Cuticular Romance, Anne F. Liu

Journal of Wellness

No abstract provided.

Identification Of Antibiotic Producing Soil Bacteria Against Bacillus Subtilis, Morgan Brockhouse, Dr. Lori Scott

Identifying and Characterizing Novel Antibiotic Producing Microbes From the Soil

This project is a collaboration with the Tiny Earth Project Initiative (TEPI), which is a global network of educators and students focused on student-sourcing antibiotic discovery from soil. Individual strains of soil bacteria were isolated and produced antibiotic against Bacillus subtilis. Two of these samples were sequenced using the 16S rRNA gene to reveal they are very closely related to the genus Pseudomonas.

Optimal Bait Density For Delivery Of Acute Toxicants To Vertebrate Pests, Kim M. Pepin, Nathan P. Snow, Kurt C. Vercauteren

United States Department of Agriculture Wildlife Services: Staff Publications

Oral baiting is a fundamental method for delivering toxicants to pest species. Planning baiting strategies is challenging because bait-consumption rates depend on dynamic processes including space use and demographics of the target species. To determine cost-effective strategies for optimizing baiting, we developed a spatially explicit model of population dynamics using field-based measures of wild-pig (Sus scrofa) space use, bait consumption, and mortality probabilities. The most cost-effective baiting strategy depended strongly on the population reduction objective and initial density. A wide range of baiting strategies were cost-effective when the objective was 80% population reduction. In contrast, only a narrow range of …

2020 January 27 - Graduate Council Minutes, College Of Graduate And Continuing Studies, East Tennessee State University

Graduate Council Agendas and Minutes

No abstract provided.

Wild Ruminants As Reservoirs Of Domestic Livestock Gastrointestinal T Nematodes, Carly D. Barone, Janneke Wit, Eric P. Hoberg, John S. Gilleard, Dante S. Zarlenga

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Gastrointestinal nematode (GIN) infections in cattle cause appetite suppression which leads to poor feed conversion, reduced weight gain and reduced milk production. Overuse and exclusive reliance on anthelmintic drugs has resulted in widespread resistance in many parasitic nematode species infecting livestock making control increasingly difficult. Wild ruminants are competent hosts of a number of nematode species that typically infect and are best adapted for cattle, sheep, and goats. Thus, the potential exists for wild ruminants to act as reservoirs in the translocation of domestic GIN, including those carrying anthelmintic resistance mutations as well as susceptible genotypes. The potential for parasite …

Brodifacoum Residues In Fish Three Years After An Island-Wide Rat Eradication Attempt In The Tropical Pacific, Shane R. Siers, Aaron B. Shiels, Steven F. Volker, Kristen Rex, William C. Pitt

United States Department of Agriculture Wildlife Services: Staff Publications

Invasive rats are known to threaten natural resources and human health and safety. Island-wide rat eradication attempts have been increasing in number and scale during the past several decades, as has the frequency of eradication success. The most common method to remove all rats from an island is to broadcast anticoagulant rodenticide bait into every rat’s home range on the island. Broadcast of toxicants can put humans and other nontarget species in marine and terrestrial environments at risk of exposure. The persistence of anticoagulant residues is somewhat unknown, particularly in marine environments. Three years after ~ 18,000 kg of 25 …

Enhancing Immunization Rates In Two Urban Academic Primary Care Clinics: A Before And After Assessment, Zeeshan Yacoob, Christopher Cook, Fabiana Kotovicz, Jessica J.F. Kram, Marianne Klumph, Marisa Stanley, Paul Hunter, Dennis J. Baumgardner

Journal of Patient-Centered Research and Reviews

Purpose: Immunization rates in many cities in the United States remain suboptimal compared to Healthy People 2020 Goals and are lower than national averages. This study aimed to determine whether a lecture-based educational intervention targeted at nurses and medical assistants would improve vaccination rates.

Methods: We conducted a quality improvement study in two urban academic family medicine clinics serving a predominantly Medicaid patient population as well as a sizable proportion of refugees. The intervention consisted of 3 lectures that were delivered to clinic nurses and medical assistants. Vaccinations in 1689 patients — 872 in the 3-month preintervention period, 817 in …

Cryptococcal Antigen Testing In An Integrated Medical System: Eastern Wisconsin, Marianne Klumph, Brian Hoeynck, Dennis J. Baumgardner

Journal of Patient-Centered Research and Reviews

Cryptococcosis is a serious environmentally acquired endemic fungal infection commonly associated with immunocompromised hosts. Little is known regarding frequency or distribution in Wisconsin. We explored the geodemographic and clinical features of patients tested with cryptococcal antigen tests (CrAg) — previously shown to be >90% sensitive and >90% specific — within a large health care system located in eastern Wisconsin. To examine this, we retrospectively analyzed 1465 CrAg tests on 1211 unique patients (female: 50.2%; white race: 73.9%; mean age: 53.7 ± 16.5 years). At least one CrAg result was positive in 23 of 1211 patients (1.9%). From these, 21 of …

Ivf Errors - Is This Only The Tip Of The Iceberg?, Jody L. Madeira, Steven R. Lindheim Md, Mark P. Trolice

Articles by Maurer Faculty

ART errors are fortunately a rare occurrence. but humans are fallible and mistakes are inevitable. As social media sensationalizes these events, we, as infertility specialists, must be vigilant in reviewing existing risk management systems and consider other options to minimize/eliminate these events. ART programs should work to emphasize honesty and transparency to improve quality of care.

Cervical Osteomyelitis: Unique Presentation And Fatal Outcome, Asma Jamil Md, Ayesha Jamil Md, Scott Kubomoto Md, Liliana Crisan Md

Internal Medicine

No abstract provided.

Novel Insights Into Immune Systems Of Bats, Arinjay Banerjee, Michelle L. Baker, Kirsten Kulcsar, Vikram Misra, Raina Plowright, Karen Mossman

KIP Articles

No abstract provided.