Digital Commons Network^™

The T, T*, Vi, Vni Model For Human Immunodeficiency Virus Type 1 (Hiv-1) Dynamics, Amy Creel

Departmental Honors & Graduate Capstone Projects

In this research project, I investigated deterministic and stochastic versions of a model for Human Immunodeficiency Virus Type 1 (HIV-1) dynamics. First, an analytical solution to a simplified version of the deterministic model is found. Then, numerical techniques are used to obtain an approximate solution to the deterministic model. Finally, a stochastic version of the model is discussed, and numerical methods are used to find an approximate solution to the stochastic system. These results demonstrate the behavior of HIV-1 in an infected patient under the effects of reverse transcriptase and protease inhibitors, and illustrate how the addition of randomness to …

The Bioethical Implications Of Genetic Screening Programs For Rare Diseases, Ellie Pitcher, Jeremy Mccallum

Honors Thesis

In the United States, there are currently thirty-five hereditary medical disorders that the Department of Health and Human Services recommends for newborn screening. The early diagnosis of these disorders is critical to the health and well-being of affected individuals. There are many more rare genetic diseases that would benefit from early diagnosis, but which do not symptomatically present until late in life or have low penetrance. Some of these genetic diseases are extremely dangerous, and would massively benefit from the early diagnosis that accompanies newborn screening in the United States. Here the benefits and risks associated with early screening for …

Forgiveness, Freedom And The Inmate Issue, Taylor Smith

Master of Arts in Professional Writing Capstones

Forgiveness Freedom and the Inmate Issue:

It is no secret that the United States has a mass incarceration problem. The war on drugs, traffic violations, and the Three Strikes Law, are just pieces of the systems being used to repeatedly place people behind bars. What we are facing now as a society is the repercussions of reintegrating under educated, digitally literate, mentally abandoned individuals back into society. In addition to post jail operatives like parole fees, fines and probation scheduling are re-sentencing these individuals into a society they no longer relate to, that socially struggle to adapt to and that …

Getting The Gold, Jody Record

UNH Today Archive

No abstract provided.

Operating Room Traffic And Surgical Site Infections: A Quality Improvement Project, Marc Parent

DNP and Student Works

The gap in practice was the excessive movement through the sub-sterile doors of the operating room. The Association of Perioperative Registered Nurses Guidelines for perioperative practice (2018) was used to guide the project aim; limiting personnel and equipment; patient and large equipment, and door openings at the appropriate times. The PICOT question was as follows: In orthopedic operating rooms' personnel, how does implementing an OR traffic protocol compared to current practice, affect OR traffic and surgical infection rates (SIRs) in a 10-week timeframe?

2020-05-05 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Mari Anixter, Alex Castillo Smith, Anistasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Lynnmarie Jarratt, Fiona Nguyen, Ryen Ormesher, Samantha Paltrow-Krulwich, Stephen Esquerra, Allison Price, Jenny Situ, Aly Raboff, Ryota Shimada, Ariel Hurwitz, Alexandra Yingling, Cristian Bologa, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM cases. Navajo cases. NM remdesivir inaccessible. Infected prison staff. No early prison releases. Unemployment beats working. NM $97M food benefits. UNM $50M revenue loss. Meat packer testing. Fall school reopening planning. Gym/salon reopening plans. 91k absentee ballots. Santa Fe closes polling stations. NM oil/gas pollution oversight. Prisons vulnerable. WH rejects FEMA report. Schools plan reopening. Italian mafia concerns. UK overtakes Italy. Symptom tracker early warning. Ethanol for FFP2 masks. Counterfeit masks. Mask skin damage. Mutant coronavirus more contagious. Hospital contamination zones. Disease prevalence estimation. Successful control measures. Average contagious period. Genetic epidemiology. Managing healthcare resources. Exercise and …

Measuring Global Scientific Research On Covid-19: A Bibliometric Analysis, Sidlingappa M. Huded, Suresh Balutagi

Library Philosophy and Practice (e-journal)

The COVID-19, become the critical health issues globally since its outbreak in China in December 2019, since, then the global research has spiked on this topic. The objective of the present study is to know the publications on COVID-19 by conducting a bibliometric analysis using available data on the Scopus database. The Selected documents related to COVID-19 extracted on 26^th April 2020 from Scopus. The following analysis parameters used for this study are the pattern of authorship, international collaboration, document types, languages, published sources, affiliations, country-wise contributions, and citations. The present study analysed 3693 publications were available as on …

Applying Modern Immunology To The Plague Of Ancient Athens, Juhi C. Patel

Pursuit - The Journal of Undergraduate Research at The University of Tennessee

During the 5^th century BCE, ancient Athens and Sparta were involved in a major war during which an epidemic disease broke out in Athens, claiming the lives of a substantial part of the population. Although the ancient Greek historian Thucydides provides a first-hand account of the symptoms of the plague, modern historians have not been able to definitively identify the pathogen that caused the deadly epidemic. In 1994, a burial tomb of Athens was unearthed that unveiled the likely remains of plague victims. In 2005, scientists conducted molecular testing on the dental remains and used suicide PCR to compare …

The Adaptor Protein P62 Mediates Ebv Lmp1 Signal Transduction, Ayrianna Sparks-Wallace, Shunbin Ning

Appalachian Student Research Forum

Epstein-Barr Virus (EBV) is well known to manipulate the host ubiquitin machinery to facilitate its latent persistence and oncogenesis, exemplified by LMP1 signal transduction that activates multiple transcription factors, including NFκB, AP1, and IRF7/IRF4, which promote cell survival and outgrowth, and control immune response and inflammation. It is therefore vital to delineate the detailed mechanisms underlying LMP1 signal transduction for understanding EBV-mediated oncogenesis. p62 (also called SQSTM1, Sequestosome 1) is a ubiquitin sensor and a signal transducing adaptor that interacts with TRAF6 and facilitates the recruitment of ubiquitinated signal intermediators for the activation of NFκB and AP1 in diverse contexts. …

Madam Protein Decreases Microsporidia Attachment To Host Cells, Cindy L. Barrett, Cheryl Moore, James Russell Hayman

Appalachian Student Research Forum

Microsporidia are an obligate, intracellular fungal pathogen that can cause devastating, disseminating infections in the immunocompromised. Because of the limitations of current medications, microsporidia’s abundant presence in the environment, and an increasing number of at-risk populations, investigation into decreasing microsporidia infectivity is needed. As an intracellular pathogen, microspridial attachment is a vital first step to infection, and if attachment is reduced, previous work shows that infectivity is mitigated. An in silico analysis of Encephalitozoon intestinalis revealed a predicted protein similar in sequence to ADAM (A Disintegrin And Metalloproteinase) proteins. This predicted protein is termed microsporidia ADAM or MADAM. ADAM proteins …

Jacksonville State University Covid-19 Short-Term Recovery Concept Paper: Return To A New Normal, Jacksonville State University

COVID-19 JSU Response & Documentation

Jacksonville State University needs a simple but functional plan now to identify goals, assign responsibilities and initiate short-term recovery operations related to the cessation of the first wave of the COVID-19 pandemic. The primary focus of the University’s recovery should be to get us back to a new normal by July 6th, 2020. The members of the Reopening Committee believe that there are three pillars to recovery operations. They are as follows: Information sharing to enable our campus community to be better informed and responsible individuals; organizational readiness through comprehensive preparedness and mitigation activities; and, a reasonable testing capacity for …

2020-05-04_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

A New Gorilla Adenoviral Vector With Natural Lung Tropism Avoids Liver Toxicity And Is Amenable To Capsid Engineering And Vector Retargeting, Zhi Hong Lu, Igor P. Dmitriev, Douglas E. Brough, Elena A. Kashentseva, Jie Li, David T. Curiel

Open Access Publications

Human adenoviruses have many attractive features for gene therapy applications. However, the high prevalence of preexisting immunity against these viruses in general populations worldwide has greatly limited their clinical utility. In addition, the most commonly used human adenovirus, human adenovirus subgroup C serotype 5 (HAd5), when systemically administered, triggers systemic inflammation and toxicity, with the liver being the most severely affected organ. Here, we evaluated the utility and safety of a new low-seroprevalence gorilla adenovirus (GAd; GC46) as a gene transfer vector in mice. Biodistribution studies revealed that systemically administered GAd had a selective and robust lung endothelial cell (EC) …

Rapid Antibiotic Susceptibility Testing Platform For Direct Clinical Samples, Terrance Zhang

Honors Scholar Theses

Infectious diseases and septicemia are two of the major causes of death in the U.S., necessitating rapid treatment of septic patients with proper, efficacious antibiotics. Unfortunately, the emergence and spread of multidrug-resistant bacteria are continuously being aggravated by an abuse in antibiotic prescription at a clinical and agricultural level. It is known that antibiotic resistance evolves through the sequential accumulation of multiple mutations in bacteria, which is accentuated by prolonged exposure of bacteria to ineffective antibiotics when implementing traditional septicemia treatment. The goal of this project is to develop a novel, easy-to-use AST platform for rapid antimicrobial susceptibility profiling to …

A National Prospective Cohort Study Of Sars/Cov2 Pandemic Outcomes In The U.S.: The Chasing Covid Cohort, Mckaylee Robertson, Sarah Kulkarni, Amanda Berry, Chloe Mirzayi, Andrew Maroko, Rebecca Zimba, Drew Westmoreland, Christina Grov, Angela Parcesepe, Levi Waldron, Denis Nash

Publications and Research

Introduction: The Chasing COVID Cohort (C 3 ) study is a US-based, geographically and socio-demographically diverse sample of adults (18 and older) enrolled into a prospective cohort study during the upswing of the U.S. COVID-19 pandemic.

Methods: We used internet-based strategies to enroll C 3 participants beginning March 28th, 2020. Following baseline questionnaire completion, study participants will be contacted monthly (for 6 months) to complete assessments of engagement in non-pharmaceutical interventions (e.g., use of cloth masks, avoiding large gatherings); COVID-19 symptoms; SARS/COV2 testing and diagnosis; hospitalizations; healthcare access; and uptake of health messaging. Dried blood spot (DBS) specimens will be …

Knowledge Graph-Enabled Cancer Data Analytics, S M Shamimul Hasan, Donna Rivera, Xiao-Cheng Wu, Eric B. Durbin, J Blair Christian, Georgia Tourassi

School of Public Health Faculty Publications

Cancer registries collect unstructured and structured cancer data for surveillance purposes which provide important insights regarding cancer characteristics, treatments, and outcomes. Cancer registry data typically (1) categorize each reportable cancer case or tumor at the time of diagnosis, (2) contain demographic information about the patient such as age, gender, and location at time of diagnosis, (3) include planned and completed primary treatment information, and (4) may contain survival outcomes. As structured data is being extracted from various unstructured sources, such as pathology reports, radiology reports, medical records, and stored for reporting and other needs, the associated information representing a reportable …

Ohio University Faculty Senate Minutes May 4, 2020, Ohio University Faculty Senate

Faculty Senate Minutes

No abstract provided.

An Indigenous Historical Case: Traumas Reflected In Modern Day Public Health, Emily Taylor Wichmann

Honors Capstone Projects and Theses

No abstract provided.

How Misinformation And Mistrust Compound The Threat Of Epidemics, William Boyd

Honors Theses

This thesis was conducted to study the effects of misinformation and medical mistrust on the public health field. I use the events of the Chapare Virus outbreak in Bolivia in the summer of 2019 and the public dialogue during that time period to discuss these themes. I used data from market survey's in La Paz, newspaper articles from Página Siete, and Tweets from the time period of the outbreak. My findings suggest that misinformation and medical mistrust affected public health measures, which has major implications for the way the public health field should address future public health events.

Isolation And Selective Glycosylation Of Antisalmonellal Anthraquinones From The Stem Bark Of Morinda Lucida Benth. (Rubiaceae), Napoleon A. Mfonku, James A. Mbah, Norbert Kodjio, Donatien Gatsing, Jixun Zhan

Biological Engineering Faculty Publications

In this work we report the isolation, identification and antibacterial activity of two anthraquinones, 2-hydroxy-1-methoxyanthraquinone (1) and 2,5-dihydroxy-1-methoxy-6-methoxymethylanthraquinone (2), from the stem bark of Morinda lucida. These two natural products were selectively converted into two new glycosylated derivatives, 2-hydroxy-1-methoxyanthraquinone-4′-O-methyl-2-O-β-d-glucopyranoside (3) and 2,5-dihydroxy-1-methoxy-6-methoxymethylanthraquinone-4′-O-methyl-2-O-β-d-glucopyranoside (4) by the filamentous fungus Beauveria bassiana ATCC 7159. Structure elucidation was accomplished based on the 1D and 2D NMR, IR and mass spectra. The glycosylated compounds 3 and 4 showed higher in vitro antibacterial activity against Salmonella enterica subsp. enterica sérovars Typhimurim (MIC of 8 μg/mL each) than the corresponding aglycons 1 and 2 (MIC of …

Uab Announces Temporary Expense Reduction Strategies Due To Covid-19, Alicia Rohan

Browse All News

No abstract provided.

Convalescent Plasma Therapy Is Treating Coronavirus Patients In Uab Research, Matt Windsor

Browse All News

No abstract provided.

Follow These Expert Guidelines To Ensure You're Covering Up Correctly, Haley Herfurth

Browse All News

No abstract provided.

Health Care Access For Children In Latinx Immigrant Families In The Greater Philadelphia Area, Sophia King

Politics Honors Papers

This work examines the gap that exists in access to health care in the Greater Philadelphia Region for children of Latinx immigrant families in comparison to other children in the nation. It provides a critical analysis of the gap in access to coverage, noting that this exists despite wide support for a human right to health. This study draws on existing scholarly research as well as interviews with staff at two health clinics and one community outreach center that are located in Greater Philadelphia. It demonstrates that Latinx immigrant families are less likely to have health insurance and get primary …

The Pandemic Pollution Ploy, Beverly Kao

Journalism

The virus should be a call to strengthen environmental protections, not roll them back.

2020-05-02_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

#Mayday, Jayne Robinson

Erma Bombeck Writers' Workshop Blog

Mayday is the international signal of distress, taken from the French word m'aider, meaning "help me!" The day has other meanings, too. Back when the world was quaint, people hung flowers and sweets on neighbors' doors on May 1. Then came the Soviet's parade of military might. In contemporary times, it's the traditional date when students declare where they will go to college (and deposit dollars in good faith). This year, Mayday has taken on yet another meaning: It's now the day when the virus that roared, SARS-COVID 19, has laid waste to all commencement ceremonies, leaving graduating seniors in …

Strategies To Optimize Control Of Opioid Overdose In The Hospital & Community Settings, Ariel K. Tate

Honors Capstones

Despite healthcare workers’ efforts to care for individuals who misuse opioids in the emergency settings, more interventions and resources need to be identified for these individuals and their families to sustain a better quality of life in all settings. This study is geared toward finding research of existing literature for effective methods on controlling and ceasing opioid overdoses in the hospital and community settings. This topic is extremely important because the number of overdoses across the nation are consistently rising. This review will highlight the statistics behind drug overdose and the many interventions out there to help in the cessation …

How Big Data And Artificial Intelligence Can Help Better Manage The Covid-19 Pandemic, Giovanni Damiani

Faculty Scholarship

SARS-CoV2 is a novel coronavirus, responsible for the COVID-19 pandemic declared by the World Health Organization. Thanks to the latest advancements in the field of molecular and computational techniques and information and communication technologies (ICTs), artificial intelligence (AI) and Big Data can help in handling the huge, unprecedented amount of data derived from public health surveillance, real-time epidemic outbreaks monitoring, trend now-casting/forecasting, regular situation briefing and updating from governmental institutions and organisms, and health facility utilization information. The present review is aimed at overviewing the potential applications of AI and Big Data in the global effort to manage the pandemic. …

Neurological Complications Of Coronavirus Disease (Covid-19): Encephalopathy, Mri Brain And Cerebrospinal Fluid Findings: Case 2, Patricio Espinosa Prado

All Publications

The neurological complications of coronavirus disease 2019 (COVID-19) are being better understood as the pandemic progresses. We report a second case of a patient who presented with COVID-19 infection and encephalopathy to our institution. In addition, we report MRI brain and cerebrospinal fluid data. COVID-19 does not seem to cross the blood-brain barrier. The exact mechanisms of encephalopathy and pathological response of COVID-19 are unknown.