Digital Commons Network^™

Comparative Evaluation Of Clinical Manifestations And Risk Of Death In Patients Admitted To Hospital With Covid-19 And Seasonal Influenza: Cohort Study, Yan Xie, Benjamin Bowe, Geetha Maddukuri, Ziyad Al-Aly

Open Access Publications

No abstract provided.

Exploring Multimedia Storytelling As A Novel Tool To Inspire Americans To Participate In Wildlife Conservation, Megan Brief

Masters Theses

Human and nonhuman animal lives are intimately entangled. In the age of the Anthropocene, it is imperative to reexamine our proximity and kinship with nature. Human-wildlife conflict can evolve into coexistence through conservation efforts marked by creativity and compassion. To inspire conservation action among North American audiences, we must enact novel ways of disseminating scientifically technical concepts. Multimedia storytelling can encourage equitable involvement among lay participants in conservation spaces. When inclusive of Indigenous knowledges, and conscious of damage narratives, such innovative stories can empathetically communicate wildlife degradation and injustices, as well as animate vulnerable human and nonhuman communities.

Working Paper No. 45, An Intellectual History Of Josiah Warren, Jaye Balentine

Working Papers in Economics

This inquiry seeks to establish that Josiah Warren (1798-1874) developed a synthesis of anti-capitalist economics and radical individualism which became a unique, yet highly practical strand of anarchism in the United States. This inquiry relies heavily upon Crispin Sartwell’s The Practical Anarchist: Writings of Josiah Warren (2011) for insight into Warren’s contributions. Warren registers as distinct because of his relative isolation from other anarchist thinkers, existing largely as a lone practitioner operating in the western territories of the United States during middle-part of the 19th century. This inquiry considers Warren’s philosophical views as well as his practical program—namely his doctrines …

Clinical Characteristics And Outcomes Of Critically Ill Patients With Covid-19 Admitted To An Intensive Care Unit In London: A Prospective Observational Cohort Study, Ross J. Thomson, Jennifer Hunter, Jonathan Dutton, James Schneider, Maryam Khosravi, Alisha Casement, Kulwant Dhadwal, Daniel Martin

Peninsula Medical School

Background Cohorts of severely ill patients with COVID-19 have been described in several countries around the globe, but to date there have been few published reports from the United Kingdom (UK). Understanding the characteristics of the affected population admitted to intensive care units (ICUs) in the UK is crucial to inform clinical decision making, research and planning for future waves of infection. Methods We conducted a prospective observational cohort study of all patients with COVID-19 admitted to a large UK ICU from March to May 2020 with follow-up to June 2020. Data were collected from health records using a standardised …

Editorial Board

Karbala International Journal of Modern Science

No abstract provided.

2020-12-14_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Feasibility Of Continuous Fever Monitoring Using Wearable Devices, Benjamin L. Smarr, Kirstin Aschbacher, Sarah M. Fisher, Anoushka Chowdhary, Stephan Dilchert, Karena Puldon, Adam Rao, Frederick M. Hecht, Ashley E. Mason

Publications and Research

Elevated core temperature constitutes an important biomarker for COVID-19 infection; however, no standards currently exist to monitor fever using wearable peripheral temperature sensors. Evidence that sensors could be used to develop fever monitoring capabilities would enable large-scale health-monitoring research and provide high-temporal resolution data on fever responses across heterogeneous populations. We launched the TemPredict study in March of 2020 to capture continuous physiological data, including peripheral temperature, from a commercially available wearable device during the novel coronavirus pandemic. We coupled these data with symptom reports and COVID-19 diagnosis data. Here we report findings from the first 50 subjects who reported …

Non-Communicable Diseases Among Adolescents: Current Status, Determinants, Interventions And Policies, N Akseer, S Mehta, J Wigle, R Chera, Z J. Brickman, S Al-Gashm, B Sorichetti, A Vandermorris, D B. Hipgrave, N Schwalbe, Zulfiqar Ahmed Bhutta

Woman and Child Health

Background: Addressing non-communicable disease (NCDs) is a global priority in the Sustainable Development Goals, especially for adolescents. However, existing literature on NCD burden, risk factors and determinants, and effective interventions and policies for targeting these diseases in adolescents, is limited. This study develops an evidence-based conceptual framework, and highlights pathways between risk factors and interventions to NCD development during adolescence (ages 10-19 years) and continuing into adulthood. Additionally, the epidemiologic profile of key NCD risk factors and outcomes among adolescents and preventative NCD policies/laws/legislations are examined, and a multivariable analysis is conducted to explore the determinants of NCDs among adolescents …

Environmental Analysis Of Bacterial Contamination In Basra City Water Using Filmarray Microbial Screening Technology, Shukri Ibrahim Al-Hassan

Uruk Journal of Human Sciences

This study aims to investigate the index of microbial contamination in water samples of Basra City. The study hypotheses that microbial contaminates in the water may be a significant reason for the health damage. The study used the advanced FilmArray Analysis Technology to detect microbial contamination in the studied water samples. Six samples of raw water were collected for different locations in Basra during March 2019, and were shipped to France for testing there in advanced laboratories.

Analyses Of The 2020 Nobel Prize In Physiology Or Medicine: Taking The Hepatitis C Virus From Mystery Killer To Preventable And Treatable Disease, Neyda V. Gilman

Library Scholarship

Harvey J. Alter, Michael Houghton, and Charles M. Rice share the 2020 Nobel in Physiology or Medicine for their contributions to the identification, treatment, and eventual elimination of the hepatitis C virus (HCV). The then novel molecular techniques they used have laid the groundwork for future work on HCV and other viruses. This article will give a brief overview of the hepatitis disease and the work of this year's laureates. It will also take a bibliometric look at the scientist’s research and add to the discussions about the way modern science is done and the limitations of prestigious science awards …

Research From Around The World: Hiv/Aids In Africa And The Us, Jason E. Farley

SigmaCast [Podcast]

This episode we will be discussing the body of nursing research from Jason E. Farley, PhD, MPH, ANP-BC, FAAN, FAANP, AACRN, a Sigma International Nurse Researcher Hall of Fame inductee in July of 2020 and a professor at Johns Hopkins University School of Nursing

Host: Matt Howard, DNP, RN, CEN, TCRN, CPEN, CPN: Director of Scholarship Resources, Sigma Theta Tau International, Indianapolis, Indiana, USA

Conversational Ontology Operator: Patient-Centric Vaccine Dialogue Management Engine For Spoken Conversational Agents, Muhammad Amith, Rebecca Z Lin, Licong Cui, Dennis Wang, Anna Zhu, Grace Xiong, Hua Xu, Kirk Roberts, Cui Tao

2020-Current year OA Pubs

BACKGROUND: Previously, we introduced our Patient Health Information Dialogue Ontology (PHIDO) that manages the dialogue and contextual information of the session between an agent and a health consumer. In this study, we take the next step and introduce the Conversational Ontology Operator (COO), the software engine harnessing PHIDO. We also developed a question-answering subsystem called Frankenstein Ontology Question-Answering for User-centric Systems (FOQUS) to support the dialogue interaction.

METHODS: We tested both the dialogue engine and the question-answering system using application-based competency questions and questions furnished from our previous Wizard of OZ simulation trials.

RESULTS: Our results revealed that the dialogue …

Elusive Diagnosis Of Behcet's Disease In Setting Of Painless Vision Loss, Arti A. Patel, Amelia Stutman, Prarak Patel, Madhavi Capoccia

Student Publications

Behcet's disease is a chronic, idiopathic vasculitis with multisystem involvement commonly characterized by the classic triad of oral lesions, genital ulcerations, and uveitis. We discuss the case of a 22-year-old woman with a long-standing history of oral ulcers and vulvovaginal burning who presented with acute painless uveitis. With this presentation, there was an initial concern for infectious retinitis for which she was started on systemic antiviral therapy. Subsequent infectious disease workup was ultimately negative. Given her medical history and current presentation, she was diagnosed and treated for an acute inflammatory episode of ocular Behcet's disease. The patient's vision returned to …

Research Output On Covid-19/Coronavirus Vaccine: A Scientometric Study, Surulinathi M, Arputha Sahaya Rani Y, Srinivasaragavan S, Jayasuriya T

Library Philosophy and Practice (e-journal)

This article presents a Scientometric analysis of Covid-19 Vaccine research Literature indexed by Web of Science. Assessing research activity is important for planning future protective and adaptive policies. The objective of the current study was to assess research activity on Covid-19 Vaccine literature. A Scientometric method was applied using Scopus, Documents on “Covid-19 literature”. The study period was from 1971 to 2020. The search query found 7181 documents in Coronavirus Vaccine literature. The growth of publications showed 4402 in 2020. Documents published in Vaccine journal received the highest number of publications (203) followed by Journal of Virology with 104 Publications, …

Highly Cited Works On Covid-19 Vaccine: A Scientometric Mapping Of Publications, Surulinathi M, Arputha Sahaya Rani Y, Prasanna Kumari N, Jayasuriya T

Library Philosophy and Practice (e-journal)

This paper attempts to highlight the growth and development of Covid-19 Vaccine literature and make the quantitative and qualitative assessment by way of analyzing various features of research output and Citations impact based on the Web of Science database. A total of 433 publications were published on Covid-19 Vaccine, which received 52567 Citations during 1989-2020. The average number of citations per publication was 121.4. The research was peaked in 2020 with 97(Which received a minimum of 500 Citations) Publications and the highest number of citations (14623) were received in 2020. USA had the highest share 229 of publications and …

Dysregulated Interferon Response Underlying Severe Covid-19, Leann Lopez, Peter C. Sang, Yun Tian, Yongming Sang

Agricultural and Environmental Sciences Faculty Research

Innate immune interferons (IFNs), including type I and III IFNs, constitute critical antiviral mechanisms. Recent studies reveal that IFN dysregulation is key to determine COVID-19 pathogenesis. Effective IFN stimulation or prophylactic administration of IFNs at the early stage prior to severe COVID-19 may elicit an autonomous antiviral state, restrict the virus infection, and prevent COVID-19 progression. Inborn genetic flaws and autoreactive antibodies that block IFN response have been significantly associated with about 14% of patients with life-threatening COVID-19 pneumonia. In most severe COVID-19 patients without genetic errors in IFN-relevant gene loci, IFN dysregulation is progressively worsened and associated with the …

2020-12-13_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Lifestyle Intervention In Gestational Diabetes (Living) In India, Bangladesh And Sri Lanka: Protocol For Process Evaluation Of A Randomised Controlled Trial, Janani Shanthosh, Deksha Kapoor, Lakshmi K. Josyula, Anushka Patel

Open Access archive

Introduction The development of type 2 diabetes mellitus disproportionately affects South Asian women with prior gestational diabetes mellitus (GDM). The Lifestyle InterVention IN Gestational diabetes (LIVING) Study is a randomised controlled trial of a low-intensity lifestyle modification programme tailored to women with previous GDM, in India, Bangladesh and Sri Lanka, aimed at preventing diabetes/pre-diabetes. The aim of this process evaluation is to understand what worked, and why, during the LIVING intervention implementation, and to provide additional data that will assist in the interpretation of the LIVING Study results. The findings will also inform future scale-up efforts if the intervention is …

Granulomatosis With Polyangiitis In A Pediatric Male, Florentino Saenz Rios, Sandhya Devaraj, Giri Movva, Hari Movva, Quan D. Nguyen

School of Medicine Publications

Significant eosinophilia is a prominent feature in Churg-Strauss syndrome but has not been described in granulomatosis with polyangiitis (GPA) in a pediatric patient. We present a biopsy case that confirmed granulomatosis with polyangiitis with significant eosinophilia > 30% on the initial presentation. Etiologies that could account for eosinophilia were excluded during workup. The patient's presentation of pulmonary alveolar hemorrhage, conjunctivitis arthritis, high-titer cytoplasmic antineutrophil, PR3-ANCA antibodies, and cytoplasmic antibodies (cANCA) was consistent with a clinical picture of atypical GPA in a pediatric patient. This case presents a rare opportunity not only due to GPA’s low incidence in the pediatric population but …

Role Of Nutraceuticals In Covid-19 Mediated Liver Dysfunction, Mohammed Sikander, Shabnam Malik, Anyssa Rodriguez, Murali M. Yallapu, Acharan S. Narula, Sanjaya K. Satapathy, Vijian Dhevan, Subhash C. Chauhan, Meena Jaggi

School of Medicine Publications

COVID-19 is known as one of the deadliest pandemics of the century. The rapid spread of this deadly virus at incredible speed has stunned the planet and poses a challenge to global scientific and medical communities. Patients with COVID-19 are at an increased risk of co-morbidities associated with liver dysfunction and injury. Moreover, hepatotoxicity induced by antiviral therapy is gaining importance and is an area of great concern. Currently, alternatives therapies are being sought to mitigate hepatic damage, and there has been growing interest in the research on bioactive phytochemical agents (nutraceuticals) due to their versatility in health benefits reported …

Bibliometric Survey On Effect Of Climate Factors On Spread Of Coronavirus (Covid-19), Seema Patil, Jay Makwana, Manish Attri

Library Philosophy and Practice (e-journal)

The new SARS-CoV-2 COVID-19 has spread quickly around the globe since it was first reported in Wuhan city of China, in December 2019 subsequent to being contracted from a zoonotic source. The main focus of this bibliometric survey is to recognize the few studies which have upheld the epidemiological hypothesis that the effect of climatic factors is playing a crucial role in the spreading of COVID-19. The analysis is done on the basis of 412 documents such as journals, articles, editorials, short surveys and some review papers. The United States contributes to the maximum number of publications followed by the …

Wildlife Trade And Covid-19: Towards A Criminology Of Anthropogenic Pathogen Spillover, Piers Beirne Phd

Department of Criminology

The general remit of this paper is the role of wildlife trade in pathogen spillover. Its underlying assumption is that, so far from being the exclusive domain of the life sciences, the study of pathogen spillover will be greatly enhanced by multi-perspectival approaches, including One Health and those employed here, namely, non-speciesist green criminology and critical animal studies. The paper moves from discussions of zoonosis, anthroponosis and wildlife trade to the emergence of COVID-19 in Wuhan, China. The paper recommends the abolition of all wildlife trade and the reclamation of wildlife habitat and broaches discussion of the extension of legal …

2020-12-12_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Prenatal Alcohol Exposure Alters Transcriptional Expression Of Stress And Tlr4-Related Immune Signaling Factors In The Brain Following Early Life Stress, Chaselyn D. Ruffaner-Hanson

Biomedical Sciences ETDs

Background: Depression and anxiety disorders, believed to be caused by stress-related neuropeptides and pro-inflammatory molecules in the brain, are prevalent comorbidities of fetal alcohol spectrum disorders (FASD).

Methods: Brain tissue was collected following a 4-hour maternal separation stress during the early postnatal period, postnatal days 10 and 12, from mice subjected to 1^st and 2^nd trimester prenatal alcohol exposure (PAE).

Hypothesis: We hypothesized that PAE leads to glucocorticoid receptor insensitivity, stress molecule overexpression, and potentiated toll-like receptor 4 (TLR4) pathway inflammatory responses in the brain following early life stress.

Results: PAE and stress increased mRNA expression of TLR4 …

The Covid-19 Pandemic: An Analysis Of Its Inequitable Impacts Towards The Black Population With Recommendations To Dismantling Institutional Racism, Elena Peterson

Master's Projects and Capstones

Due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the 2020 coronavirus disease pandemic uncovered health inequities throughout the United States. This paper explores institutional racism as the reasoning behind these health inequities. A discussion of the United States’ failure to implement preventative precautions once notified initially of the coronavirus is featured. Events that took place after the recognition of the coronavirus, such as the economic impacts and passed legislation, are highlighted as well. An overview of the Trump Administration’s lack of focus towards vulnerable populations, which includes the Black communities, is included. Also, there are highlights on …

The Role Of Anti-Inflammatory Cytokine Interleukin-10 (Il-10) In Tauopathies, Lea L. Weston

Biomedical Sciences ETDs

Tauopathies are neurodegenerative diseases, including Alzheimer’s disease, that are associated with pathological accumulation of the microtubule associated protein tau (MAPT, or tau) (Lee et al., 2001). Abnormal hyperphosphorylated tau (pTau) strongly correlate with cognitive impairment (Nelson et al., 2012). Neuroinflammation is also associated with tauopathies (Gerhard et al., 2006b; Edison et al., 2008) and is implicated in driving tau pathology (Yoshiyama et al., 2007, Maphis et al., 2015b). Therefore, it is compelling to understand the role of anti-inflammatory cytokines in limiting neuroinflammation and tau pathology. Interleukin-10 (IL-10) is a well-established anti-inflammatory cytokine with roles in limiting inflammation in the central …

Bibliometric Survey On Effects Of Climate Change On Incidences Of Infectious Diseases, Seema Harshad Patil, Yatharth Jain, Vedant Marathe

Library Philosophy and Practice (e-journal)

^{For understanding the influx of Infectious Diseases, research of climate change and its effects pertaining to the diseases is important. The motive of this bibliometric survey is to understand the research which has been carried out regarding the aforementioned topics. This paper summarizes the research in the 21st Century from 2001 to present. We conducted this analysis using tools such as Gephi, Researchgate, Scopus, ScienceScape, Google Scholar and Mapchart. This Bibliometric Survey on “Effects of Climate Change on Infectious Diseases” showed that maximum publications are articles. These publications are from conferences and journals related to Environmental Science. The United States …}

December 11, 2020: Letter From The President- Covid Update, Kettering University

Communication Updates

No abstract provided.

Development Of A Disaster Preparation Toolkit To Improve Community Resilience, Tiffany Wong

Doctor of Nursing Practice (DNP) Projects

Problem: Natural and man-made disasters happen in all communities and negatively impact the health and safety of populations. Vulnerable populations, such as older adults with comorbidities and disabilities or those aging in place, face greater challenges and have specific needs when faced with disasters. The physical, psychosocial, and cultural characteristics of older adults place them at greater risk during disasters. Emergency preparedness is necessary to build and improve community resilience, as well as to ensure older adults aging in place have the necessary supplies and support to respond to a disaster. Without a proper action plan, recovery efforts during disaster …

2020-12-11_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …