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2020

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Protective Effects Of Lusianthridin On Hemin-Induced Low Density Lipoprotein Oxidation And Foam Cell Formation Of Raw 264.7 Macrophage Cells, Su Wutyi Thant Jan 2020

Protective Effects Of Lusianthridin On Hemin-Induced Low Density Lipoprotein Oxidation And Foam Cell Formation Of Raw 264.7 Macrophage Cells, Su Wutyi Thant

Chulalongkorn University Theses and Dissertations (Chula ETD)

Oxidation of low-density lipoprotein (LDL) take parts in a crucial role in the pathogenesis of atherosclerosis. Hemin (iron (III)-protoporphyrin IX) is a degradation product of hemoglobin and cause oxidative stress-promoting vascular complications in thalassemia patients. Hemin was used as an oxidizing agent for LDL oxidation. Lusianthridin (LST) from Dendrobium venustum is a plant phenolic compound and possess antioxidant activity. The aim of this study is to evaluate the protective effect of lusianthridin on hemin-induced LDL oxidation (he-oxLDL) and foam cell formation in RAW 264.7 macrophage cell loaded with he-oxLDL treated with LST. Various concentrations of LST (0.25, 0.5, 1 and …

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Production And Characterization Of Anti-Receptor Activator Of Nuclear Factor Kappa-B Ligand Monoclonal Antibody From Nicotiana Benthamiana, Wanuttha Boonyayothin Jan 2020

Production And Characterization Of Anti-Receptor Activator Of Nuclear Factor Kappa-B Ligand Monoclonal Antibody From Nicotiana Benthamiana, Wanuttha Boonyayothin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Anti-RANKL monoclonal antibody is a fully human monoclonal antibody (mAb) available for treatment of osteoporosis. In this study, anti-RANKL mAb was transiently expressed using the Geminiviral expression system in Nicotiana benthamiana. Moreover, the structure of plant-produced mAb was characterized and functional activity was also determined. The result indicated that anti-RANKL mAb was produced with the maximum expression level on 8 days post infiltration and estimated to be 0.5 mg/g leaf fresh weight. The recombinant mAb from crude extracts was purified by using protein A affinity column chromatography. The plant-produced mAb provided in vitro affinity binding with human RANKL, determined by …

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Anti-Migratory And Anti-Invasive Activities Of 22-O-(N-Boc-L-Glycine) Ester Of Renieramycin M Against Human Lung Cancer H460 Cells, Yamin Oo Jan 2020

Anti-Migratory And Anti-Invasive Activities Of 22-O-(N-Boc-L-Glycine) Ester Of Renieramycin M Against Human Lung Cancer H460 Cells, Yamin Oo

Chulalongkorn University Theses and Dissertations (Chula ETD)

The incidence of metastasis stage crucially contributes to high recurrence and mortality rate in lung cancer patients. Unfortunately, no available treatment inhibits migration, a key metastasis process in lung cancer. In this study, the effect of 22-O-(N-Boc-L-glycine) ester of renieramycin M (22-Boc-Gly-RM), a semi-synthetic amino ester derivative of bistetrahydroisoquinolinequinone alkaloid isolated from Xestospongia sp., on migratory behavior of human lung cancer cells was investigated. Following 24 h of treatment, 22-Boc-Gly-RM at non-toxic concentrations (0.5-1 µM) effectively restrained motility of human lung cancer H460 cells assessed through wound healing, transwell migration and multicellular spheroid models. The capability to invade through matrix …

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Efficacy And Safety Of Mulberry Leaves On Glycemic Control In Patients With Obesity And Patients With Type 2 Diabetes, Thanchanit Thaipitakwong Jan 2020

Efficacy And Safety Of Mulberry Leaves On Glycemic Control In Patients With Obesity And Patients With Type 2 Diabetes, Thanchanit Thaipitakwong

Chulalongkorn University Theses and Dissertations (Chula ETD)

This work was divided into three study phases: the two-phase randomized controlled clinical trials and proteomics study. First, the phase I clinical trial aimed to determine efficacy and safety of mulberry leaves on postprandial glucose following the 50-g sucrose ingestion in healthy nondiabetic adults and to explore the optimal administered dose of 1-deoxynojirimycin (DNJ), the major antihyperglycemic compound of mulberry leaves. The results showed the alleviation of postprandial hyperglycemia by mulberry leaves in a dose-dependent fashion. Adverse effects of mulberry leaves included bloating and flatulence, loose stool, and nausea. In addition, 12 mg of DNJ was considered the optimal dose …

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Policy Engagements For A Just Decarbonisation: China's 2060 Carbon Neutrality Pledge's Ramifications On The Coal Industry Workforce In Shanxi, Lucile Charriaut Jan 2020

Policy Engagements For A Just Decarbonisation: China's 2060 Carbon Neutrality Pledge's Ramifications On The Coal Industry Workforce In Shanxi, Lucile Charriaut

Chulalongkorn University Theses and Dissertations (Chula ETD)

To achieve its ambitious carbon neutrality pledge by 2060, China, whose energy mix is still largely dominated by coal, must progressively phase out coal-fired power plants. Being highly polluting, coal is no longer perceived as suitable to promote a sustainable, clean, and long-standing economy. Shanxi, a landlocked northern province, is considered one of China's most coal-dependent provinces and accounts for a colossal coal workforce depending on the industry. Such a transition will, therefore, considerably alter the economic prospects and labour relations of this province. Considering the inevitability to lay off coal workers, the objective of this thesis is to determine …

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การศึกษาหาปัจจัยที่ใช้พยากรณ์การใช้ยาวาร์ฟารินที่ไม่ได้ประสิทธิภาพในคนไทยที่มีภาวะหัวใจห้องบนเต้นผิดจังหวะแบบสั่นระริกที่ไม่ได้เกิดจากลิ้นหัวใจผิดปกติ, ปิโยรส เลิศสงวนสินชัย Jan 2020

การศึกษาหาปัจจัยที่ใช้พยากรณ์การใช้ยาวาร์ฟารินที่ไม่ได้ประสิทธิภาพในคนไทยที่มีภาวะหัวใจห้องบนเต้นผิดจังหวะแบบสั่นระริกที่ไม่ได้เกิดจากลิ้นหัวใจผิดปกติ, ปิโยรส เลิศสงวนสินชัย

Chulalongkorn University Theses and Dissertations (Chula ETD)

ที่มาและความสำคัญ: ผู้ป่วยที่มีภาวะหัวใจห้องบนเต้นผิดจังหวะแบบสั่นระริกที่ไม่ได้เกิดจากลิ้นหัวใจผิดปกติในประเทศไทย และในประเทศต่างๆของทวีปเอเชียซึ่งมีปัญหาในแง่เศรษฐานะ โดยส่วนใหญ่จะได้รับการรักษาด้วยยาวาร์ฟาริน เพื่อป้องกันการเกิดหลอดเลือดสมองอุดตัน และภาวะลิ่มเลือดหลุดลอยไปอุดตันหลอดเลือดแดงต่างๆ โดยพบว่าประสิทธิภาพของยาวาร์ฟารินขึ้นกับค่าของ Time in therapeutic range (TTR) และพบว่าค่า TTR ที่น้อยกว่าร้อยละ 65 จะทำให้ประสิทธิภาพของยาวาร์ฟารินลดลงอย่างมาก ในปัจจุบันมีการใช้คะแนน SAMe-TT2R2 ในการพยากรณ์ค่า TTR แต่การศึกษาส่วนใหญ่เป็นการศึกษาในประชากรผิวขาว และพบว่าคะแนนSAMe-TT2R2 ให้คะแนนคนเอเชียเริ่มที่ 2 คะแนนตั้งแต่ต้น ดังนั้นจากปัจจัยด้านเชื้อชาติ อาจส่งผลทำให้การประเมินผู้ป่วยที่จะไม่ได้ประสิทธิภาพจากยาวาร์ฟารินมากเกินความเป็นจริง วัตถุประสงค์: เพื่อศึกษาหาปัจจัยที่มีผลต่อการพยากรณ์การใช้ยาวาร์ฟารินที่ไม่ได้ประสิทธิภาพ (โดยมีค่า TTR ที่น้อยกว่าร้อยละ 65)ในคนไทยที่มีภาวะหัวใจห้องบนเต้นผิดจังหวะแบบสั่นระริกที่ไม่ได้เกิดจากลิ้นหัวใจผิดปกติ และหา New scoring system ขึ้นมาใหม่ เพื่อใช้พยากรณ์การใช้ยาวาร์ฟารินที่ไม่ได้ประสิทธิภาพ (โดยมีค่า TTR ที่น้อยกว่าร้อยละ 65) และเปรียบเทียบ New scoring system กับคะแนนSAMe-TT2R2 ในการพยากรณ์การใช้ยาวาร์ฟารินที่ไม่ได้ประสิทธิภาพ ในคนไทยที่มีภาวะหัวใจห้องบนเต้นผิดจังหวะแบบสั่นระริกที่ไม่ได้เกิดจากลิ้นหัวใจผิดปกติ ระเบียบวิธีวิจัย: ทำการศึกษาแบบทบทวนย้อนหลังจากเวชระเบียนผู้ป่วยนอกและในโรงพยาบาลจุฬาลงกรณ์ โดยรวบรวมผู้ป่วยภาวะหัวใจห้องบนเต้นผิดจังหวะแบบสั่นระริกที่ไม่ได้เกิดจากลิ้นหัวใจผิดปกติที่ได้รับการรักษาด้วยยาวาร์ฟารินทุกราย ตั้งแต่วันที่ 1 มกราคม พ.ศ.2557 ถึงวันที่ 31 ธันวาคม พ.ศ.2561 ในงานวิจัยนี้จะคำนวณค่า TTR ด้วย Rosendaal's Method และ ใช้ค่า TTR ที่น้อยกว่าร้อยละ 65 เพื่อบ่งบอกถึงการใช้ยาวาร์ฟารินที่ไม่ได้ประสิทธิภาพ ผลการศึกษา: ผู้ป่วยภาวะหัวใจห้องบนเต้นผิดจังหวะแบบสั่นระริกที่ไม่ได้เกิดจากลิ้นหัวใจผิดปกติที่ได้รับการรักษาด้วยยาวาร์ฟารินที่เข้ามาในงานวิจัยมีทั้งหมด 864 คน มีค่าเฉลี่ยอายุ 73.6 ± 11.58 ปี มีค่าเฉลี่ยค่า TTR คิดเป็นร้อยละ 48.1 ± 25.2 และพบว่าผู้ป่วย 637 คน คิดเป็นร้อยละ 73.7 ที่มีค่า TTR น้อยกว่าร้อยละ 65 จากการวิเคราะห์หาปัจจัยที่สัมพันธ์กับการพยากรณ์การใช้ยาวาร์ฟารินที่ไม่ได้ประสิทธิภาพ (TTRน้อยกว่าร้อยละ 65) …

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กลูโคสไบโอเซ็นเซอร์แบบไม่ใช้เอนไซม์จากคอปเปอร์ออกไซด์/รีดิวซ์กราฟีนออกไซด์นาโนคอมพอสิต, นพรัตน์ จันทร์มี Jan 2020

กลูโคสไบโอเซ็นเซอร์แบบไม่ใช้เอนไซม์จากคอปเปอร์ออกไซด์/รีดิวซ์กราฟีนออกไซด์นาโนคอมพอสิต, นพรัตน์ จันทร์มี

Chulalongkorn University Theses and Dissertations (Chula ETD)

ในงานวิจัยนี้กลูโคสไบโอเซ็นเซอร์แบบไม่ใช้เอนไซม์ถูกพัฒนาขึ้นโดยใช้นาโนคอมพอสิตของโลหะออกไซด์และรีดิวซ์กราฟีนออกไซด์ ขั้วไฟฟ้าคาร์บอนพิมพ์สกรีนถูกดัดแปรด้วยรีดิวซ์ กราฟีนออกไซด์เพื่อเพิ่มการนำไฟฟ้าและดัดแปรด้วยโลหะออกไซด์ที่มีขนาดในระดับนาโนสองชนิด ได้แก่ คอปเปอร์ออกไซด์ และซิงค์ออกไซด์เพื่อเป็นตัวเร่งทางเคมีไฟฟ้าสำหรับการเกิดออกซิเดชันโดยตรงของกลูโคส โดยศึกษาความเข้มข้นของสารดัดแปรที่เหมาะสมด้วยกล้องจุลทรรศน์อิเล็กตรอนแบบส่องกราด จากนั้นเปรียบเทียบประสิทธิภาพการเร่งปฏิกิริยาของขั้วไฟฟ้าดัดแปรด้วยโลหะออกไซด์ด้วยเทคนิคไซคลิกโวล แทมเมทรีพบว่าขั้วไฟฟ้าคาร์บอนพิมพ์สกรีนที่ถูกดัดแปรด้วยรีดิวซ์กราฟีนออกไซด์และคอปเปอร์ออกไซด์ให้กระแสสูงสุด จึงเลือกมาใช้เป็นขั้วไฟฟ้าสำหรับกลูโคสไบโอเซ็นเซอร์แบบไม่ใช้เอนไซม์ สำหรับการตรวจวัดกลูโคสในตัวอย่างจริง อุปกรณ์รูปแบบใหม่ถูกสร้างขึ้นโดยติดกระดาษพิมพ์แวกซ์ที่เคลือบด้วยโซเดียมไฮดรอกไซด์เพื่อเป็นส่วนป้อนสารตัวอย่างลงบนขั้วไฟฟ้าคาร์บอนพิมพ์สกรีนที่ถูกดัดแปรด้วย รีดิวซ์กราฟีนออกไซด์และคอปเปอร์ออกไซด์ อุปกรณ์นี้ถูกใช้ตรวจวัดกลูโคสในฟอสเฟตบับเฟอร์ซาลีนแสดงช่วงความเป็นเส้นตรงที่ 0.125 ถึง 7.0 มิลลิโมลาร์ และ 0.031 ถึง 7.0 มิลลิโมลาร์ โดยมีค่าสัมประสิทธิ์สหสัมพันธ์ที่ 0.9940 และ 0.9911 สำหรับการตรวจวัดด้วยเทคนิคไซคลิกโวลแทมเมทรีและเทคนิคแอมเพอโรเมทรี ตามลำดับ นอกจากนี้ขั้วไฟฟ้าคาร์บอนพิมพ์สกรีนที่ถูกดัดแปรด้วยรีดิวซ์กราฟีนออกไซด์และคอปเปอร์ออกไซด์สามารถคงประสิทธิภาพการตรวจวัดได้ถึง 6 วันภายหลังการเตรียมอุปกรณ์ กลูโคสไบโอเซ็นเซอร์แบบไม่ใช้เอนไซม์ที่พัฒนาขึ้นนี้จึงสามารถประยุกต์เป็นอุปกรณ์ทางเลือกสำหรับติดตามผู้ป่วยโรคเบาหวานอย่างง่ายโดยไม่ต้องเตรียมตัวอย่าง

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Public Health Entomology Certificate Preparation Course For Esa, Sylvia Kenmuir Jan 2020

Public Health Entomology Certificate Preparation Course For Esa, Sylvia Kenmuir

Department of Entomology: Distance Master of Science Projects

My Master’s Project was to develop a preparation course for the Entomological Society of America (ESA) Public Health Entomology (PHE) Certificate. This is a new program for ESA. Unlike the Board Certified Entomologist (BCE) or Associate Certified Entomologist (ACE) programs which are certifications, the PHE is a standalone certificate in the area of public health. This certificate seeks to identify people who want to further demonstrate public health as an area of expertise. This course will be available to any qualified and approved person seeking to offer preparation course to assist people in preparing for the exam. Currently there is …

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The Effect Of Wildlife Wellbeing On Environmental Concern, Laura Casne Jan 2020

The Effect Of Wildlife Wellbeing On Environmental Concern, Laura Casne

Department of Environmental Studies: Undergraduate Student Theses

Environmental campaigns have used animal imagery to push their initiatives for years, shocking viewers with images of human caused damage to change environmental behavior. The Royal Society for the Prevention of Cruelty to Animals (RSPCA), a nonprofit located in Britain released a statement that they responded to 5000 calls annually regarding litter and that the main victims were wildlife species (Litter and Animals | Rubbish and Animals - RSPCA, 2017). A previous study done by Schultz (2000) showed animals in different conditions (animals in nature and animals harmed in nature), with results indicated that those who viewed an image of …

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Ecological Perspectives Of The Eastern Saline Wetlands Differ Between Visitors And Non-Visitors, Peter Janda Jan 2020

Ecological Perspectives Of The Eastern Saline Wetlands Differ Between Visitors And Non-Visitors, Peter Janda

Department of Environmental Studies: Undergraduate Student Theses

The Eastern Saline Wetlands of Nebraska can be found in both Lancaster and Saunders counties in Eastern Nebraska. Due to the wetlands’ important services in the areas of recreation, wildlife habitat, and flood control, it is necessary to know the extent to which these services are valued and used by residents of Lincoln . Past research completed in 2015 by the Lower Platte South NRD observed public opinions toward wetland restoration and preservation, finding that 46% of the public strongly support it, 35% mildly support it and 16% do not support it (Saline Wetlands Conservation Partnership, 2006). This past study …

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Incorporating Tallgrass Prairie Into Urban Environments, Daniel Hauschild Jan 2020

Incorporating Tallgrass Prairie Into Urban Environments, Daniel Hauschild

Department of Environmental Studies: Undergraduate Student Theses

As an agricultural state with a population poised to shift to primarily urban based, Nebraska is in the unique position of being able to decide how people live in modern cities. While the benefits of including green spaces in urban areas are well documented, evidence also suggests that increased biodiversity in these areas compounds those benefits. As such, incorporating elements of functioning natural ecosystems within urban areas can potentially create pockets of sustainable landscapes. Nebraska’s two largest population centers are located on land that was historically tallgrass prairie, an iconic landscape in American history and now almost entirely absent from …

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Growth And Feeding Response In Python Regius In Ambient Temperature Vs. Hot-Spot, Mckenzie Martinez Jan 2020

Growth And Feeding Response In Python Regius In Ambient Temperature Vs. Hot-Spot, Mckenzie Martinez

Department of Environmental Studies: Undergraduate Student Theses

Python regius, also known as the ball python or the royal python, is one of the most popular reptiles in the pet trade and has been heavily imported, kept, and bred in captivity since 1976 (Toudonou 1). This species has adapted to life in captivity extremely well making it one of the most popular reptiles in the reptile trade. It is one of the first reptiles many reptile enthusiasts own. It is a frequently used species for educating the public in zoos and other facilities. Some of the main reasons that Python regius has maintained its popularity in the reptile …

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The Effects Of Street Tree Site Planting Width On Canopy Width And Ability To Provide Ecosystem Services, Ryan Kendall Jan 2020

The Effects Of Street Tree Site Planting Width On Canopy Width And Ability To Provide Ecosystem Services, Ryan Kendall

Department of Environmental Studies: Undergraduate Student Theses

In a time where pests such as emerald ash borer are reducing urban forests, it is important to gain a return on investment for new trees planted. Since trees cost money, the value of the ecosystem services that they provide over the course of their lives should outweigh their costs. Due to the need for a return on investment, it is important to know whether newly planted street trees are being planted in a space that does not inhibit their growth or ability to provide benefits. This study, in Lincoln, NE looks to determine the relationship between a street tree’s …

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Planning Urban Forests In A Changing Climate, Ethan Dudden Jan 2020

Planning Urban Forests In A Changing Climate, Ethan Dudden

Department of Environmental Studies: Undergraduate Student Theses

As the effects of negative effects of climate change are realized, urban forests a means to reduce the potential damage and adverse conditions in urban areas (Wolf, et al., 2020) (Livesley, McPherson, & Calfapietra, 2016) (Xiao & McPherson, 2002). Preserving these resources is becoming more difficult however, as the trees that make up urban landscapes become less adapted to current conditions with every passing year (Aitken, Yeaman, Holliday, Wang, & Sierra, 2008). Changes in climate and world systems also point to invasive pests becoming greater threats to urban forest resources with time (Tubby & Webber, 2010) (Amberger et al., 2017). …

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Future Implications Of Extreme Heat On Public Health For Those Living In Lincoln, Nebraska, Mandy Koehler Jan 2020

Future Implications Of Extreme Heat On Public Health For Those Living In Lincoln, Nebraska, Mandy Koehler

Department of Environmental Studies: Undergraduate Student Theses

Increasing temperatures are expected as the climate crisis progresses. This crisis is fueled by the increasing amount of greenhouse gas emissions being released into the atmosphere, which trap heat in the environment. With rising temperatures, more extreme heat events threaten multiple sectors of society including public health. To gain insight into future climate issues related to warming temperatures and public health for people living in Lincoln, Nebraska, this research will evaluate the predicted extent of extreme heat for this area and consider what other relevant regions do to deal with these problems. This study identifies the scope of future extreme …

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Association Between Factors Related And Stress, Depression And Suicidal Risk Among Health Care Personnel During Covid-19 Second Outbreak In Thailand, Aphichaya Polrak Jan 2020

Association Between Factors Related And Stress, Depression And Suicidal Risk Among Health Care Personnel During Covid-19 Second Outbreak In Thailand, Aphichaya Polrak

Chulalongkorn University Theses and Dissertations (Chula ETD)

Health care personnel are one of most affected by COVID-19 situation. The aim of this study was to identify the prevalence of stress, depression and suicidal risk and associated factors among health care personnel during COVID-19 second outbreak in Thailand. This study was cross-sectional study, which used secondary data collected during December 17, 2020 to February 23, 2021. Total of 4,970 health care personnel participated in this research. The instruments of this research were ST-5, 9Q and 8Q. Multivariable logistic regression analysis was performed to identify factors associated with stress, depression and suicidal risk outcomes. The prevalence of stress, depression …

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Prevalence And Factors Associated With Maternal Near-Miss In Magway Regional Hospital, Magway, Myanmar, Aye Myo Thet Jan 2020

Prevalence And Factors Associated With Maternal Near-Miss In Magway Regional Hospital, Magway, Myanmar, Aye Myo Thet

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Maternal mortality is an important public health concern. Women die every day from pregnancy complications, delivery-related issues, and childbirth. Pregnancy related morbidity and mortality in Myanmar were dramatically increased from 17.6% in 2012 to 20.2% in 2018. In Myanmar, there are limited studies on maternal near miss. Therefore, this study aimed to estimate the prevalence and determine the factors associated with maternal near miss in Magway Regional Hospital, Myanmar. Method: This cross-sectional study employed a health facility-based secondary data analysis to estimate the prevalence of maternal near miss cases, and examine factors associated with maternal near miss in Magway …

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Artificial Neural Network For Pulmonary Rifampicin Resistant Tuberculosis Screening Indonesia : A Study In Accuracy And Cost-Effectiveness Analysis Of The Model, Bumi Zulheri Herman Jan 2020

Artificial Neural Network For Pulmonary Rifampicin Resistant Tuberculosis Screening Indonesia : A Study In Accuracy And Cost-Effectiveness Analysis Of The Model, Bumi Zulheri Herman

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Diagnosis of Pulmonary Rifampicin Resistant Tuberculosis (RR-TB) with the Drug-Susceptibility Test (DST) is costly and time-consuming, and the GeneXpert for rapid diagnosis is not widely available in Indonesia. This study aims to develop an Artificial Neural Network model and evaluate the deployed model performance for RR-TB screening. Methods: A cross-sectional study involved suspected RR-TB patients with complete sputum Lowenstein Jensen DST (reference) and 19 clinical, laboratory, and radiology parameter results, retrieved from medical records in hospitals under the Faculty of Medicine, Hasanuddin University Indonesia, from January 2015-December 2019. The Artificial Neural Network (ANN) models were built along with other …

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Phytochemical Screening, In Vitro Antimalarial Activity And Genetic Diversity Of Selected Asteraceae Medicinal Plants Indigenous To Thailand, Desy Liana Jan 2020

Phytochemical Screening, In Vitro Antimalarial Activity And Genetic Diversity Of Selected Asteraceae Medicinal Plants Indigenous To Thailand, Desy Liana

Chulalongkorn University Theses and Dissertations (Chula ETD)

The emergence of artemisinin resistance leaded the effort to find the new antimalarial drug or artemisinin activity booster. Due to the chance that secondary metabolites can be evolutionary conserved, combining phylogeny with ethnobotanical data for screening antimalarial activity may be helpful to predict bioactivity and minimize the expenditure and time for laboratory research. The aimed of this study is screening the antimalarial activity, phytochemicals and genetic diversity of selected Asteraceae medicinal plants generated by combinatorial phylogeny and ethnobotanical data. 733 medicinal plants were obtained from literature search however only 340 taxa were met the inclusion and exclusion criteria hence these …

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Effects Of Mcs Program On Brain-Derived Neurotrophic Factor, Interleukin-6, 25-Hydroxy Vitamin D And Depression Among Office Workers With Mild Depression, Chirra Taworntawat Jan 2020

Effects Of Mcs Program On Brain-Derived Neurotrophic Factor, Interleukin-6, 25-Hydroxy Vitamin D And Depression Among Office Workers With Mild Depression, Chirra Taworntawat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Globally, major depressive is the primary cause of disability. A large part of cases is reported among the working-class. Literature reviews suggest that the disorder is tied in with immune dysregulation and inflammatory response. This study aimed to assessed MCS (mindfulness meditation + curcumin supplementation + sunlight exposure) program by comparing with a control group among mildly depressed office workers. Methods: A quasi experiment was conducted with a total of 68 male and female office workers, n=34 being treatment group (TG) and n=34 being control group (CG). The groups were compared in terms of (a) serum brain-derived neurotrophic factor …

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Determinants Of Maternal Health Services Utility Among Adolescent Mothers In Indonesia : An Analysis Of 2017 Indonesia Demographic And Health Survey, Dewi Nuryana Jan 2020

Determinants Of Maternal Health Services Utility Among Adolescent Mothers In Indonesia : An Analysis Of 2017 Indonesia Demographic And Health Survey, Dewi Nuryana

Chulalongkorn University Theses and Dissertations (Chula ETD)

Maternal Mortality Ratio (MMR) in Indonesia remains high with 305 death per 100,000 live birth in 2015. Approximately 36 of 1000 adolescent girls (15-19 years old) in Indonesia experienced childbirth and face the higher risk for maternal mortality than older women. The aims of this study are to assess maternal health services utility (antenatal care (ANC), delivery services, and postnatal care (PNC)) level and to identify determinants of maternal health services utility among adolescent mothers in Indonesia. The design of this study is cross-sectional survey using secondary data from 2017 Indonesia Demographic and Health Survey (IDHS). The study population is …

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Pharmacognostic Specification And Rotenone Content In Derris Elliptica Stems, Macroscopic, Microscopic And Molecular Identification Of Selected Derris Species In Thailand, Krittapat Phairoh Jan 2020

Pharmacognostic Specification And Rotenone Content In Derris Elliptica Stems, Macroscopic, Microscopic And Molecular Identification Of Selected Derris Species In Thailand, Krittapat Phairoh

Chulalongkorn University Theses and Dissertations (Chula ETD)

The genus Derris belonging to Fabaceae family are distributed along the equatorial zone in Africa and Asia. In Thailand, 16 species of Derris species can be found throughout the country. Derris elliptica (Hanglai-Dang), is well-known among fishermen and gardeners as fish poison and insecticide, especially the stem and root which contain isoflavonoid compound named rotenone. This study established the pharmacognostic specification of Derris elliptica dried stem crude drug and developed the quantitative analysis of rotenone content in D. elliptica stem using TLC-densitometry and image analysis. The physico-chemical parameters of D. elliptica stem included total ash, acid-insoluble ash, loss on drying …

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Genetic Diversity Of Merozoite Surface Protein 1 Gene Of Plasmodium Falciparum In Thailand, May Myat Thu Jan 2020

Genetic Diversity Of Merozoite Surface Protein 1 Gene Of Plasmodium Falciparum In Thailand, May Myat Thu

Chulalongkorn University Theses and Dissertations (Chula ETD)

In 2030, World health organization's target is to eliminate malaria at least in 35 countries. At present, Thailand is low risk of malaria so that, it has the potential to eliminate. About 10 years ago, malaria prevalence was high along the country border areas. To prevent the recurrence in those areas, evaluation of drug susceptibility of parasites and vaccine are important. Therefore, basic knowledge on genetic diversity in malaria parasite is needed. Merozoite surface protein 1(msp1), one of the vaccine candidate genes, is useful for monitoring genetic diversity of the parasite and the potential gene of vaccine. However, high diversity …

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Cost Effectiveness Of Oral Health Care Program Implementation In Primary School In Bangkok, Thailand, Nicha Luksamijarulkul Jan 2020

Cost Effectiveness Of Oral Health Care Program Implementation In Primary School In Bangkok, Thailand, Nicha Luksamijarulkul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Dental caries are common oral diseases in schoolchildren. This retrospective cohort analysis was done to assess caries prevalence, risk and protective factors associated permanent caries among 433 children profiles of school children in selected primary school in Bangkok who received or did not receive a preventive program. Additionally, a cost effectiveness of the program was analyzed. Result revealed that there was high caries prevalence in deciduous teeth (1st grade) 87.2% and mean dmft 6.44 (± 4.4) and caries prevalence in permanent teeth (6th grade) 51.7% and mean DMFT 1.37 (± 1.84). Risk and protective factors associated permanent caries, after logistic …

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Factors Associated With Knowledge And Awareness Of Syphilis Among The Youths Visiting Family Planning Clinics, Bangkok, Thailand, Nutcha Tattanon Jan 2020

Factors Associated With Knowledge And Awareness Of Syphilis Among The Youths Visiting Family Planning Clinics, Bangkok, Thailand, Nutcha Tattanon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Syphilis has been controlled since 1960. However, syphilis is now reappearing in some areas in Africa and South-east Asia including Thailand. In Thailand, syphilis is reappearing in all regions. The most high-risk population is the youth aged 15-24 year. Objective of this study aimed to determine factors associated with knowledge and awareness of syphilis prevention among youths visiting at family planning clinic, Bangkok, Thailand. Method of this study was a cross-sectional study conducted by purposive sampling among the youth aged 15-24 years old who visit at PPAT family planning clinic, Bangkok, Thailand during April-June 2021. Multivariable logistic regression analysis was …

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Factors Associated With Retirement Preparation Among Formalworkers In Near Retirement Age: A Cross-Sectional Study, Nuttapat Kulabut Jan 2020

Factors Associated With Retirement Preparation Among Formalworkers In Near Retirement Age: A Cross-Sectional Study, Nuttapat Kulabut

Chulalongkorn University Theses and Dissertations (Chula ETD)

In the past few decades, the fast-growing life expectancy has raised concern over retirement issues worldwide, including in Thailand. While insufficient preparation for retirement has been known to link with negative impacts on both physical and mental health of retirees, there is still little research done on retirement preparation and planning among the Thai older person. Thus, the present study aims to determine the level of retirement preparation among formal workers at near retirement age in a public sector. This study was conducted in May-June 2021 via a 45-minute self-administered questionnaire with 226 participants aged 55-59 years old; participants were …

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Pharmacognostic Specifications And Chlorogenic Acid Content Of Morus Alba Linn. Leaves In Thailand, Phimkun Aiyarakanchanakun Jan 2020

Pharmacognostic Specifications And Chlorogenic Acid Content Of Morus Alba Linn. Leaves In Thailand, Phimkun Aiyarakanchanakun

Chulalongkorn University Theses and Dissertations (Chula ETD)

Morus alba Linn., belonging to Moraceae family, is commonly used as an herb. M. alba leaves are widely used in traditional Chinese medicine and Thai traditional medicine. It used to treat colds caused by wind-heat, sore throat, cough, eye inflammation, etc. This study aimed to investigate the pharmacognostic specifications and analyze the content of chlorogenic acid in M. alba leaves. M. alba leaves were collected from 15 different sources throughout Thailand. The fresh mature leaves were used for macroscopic and microscopic evaluations. The macroscopic details were illustrated as drawings. The microscopic evaluation showed the details of the leaf constant number …

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Pharmacognostic Specification And Rosmarinic Acid Content Of Mentha Cordifolia Leaves And Stems In Thailand, Ploychat Chamnanthongpiwan Jan 2020

Pharmacognostic Specification And Rosmarinic Acid Content Of Mentha Cordifolia Leaves And Stems In Thailand, Ploychat Chamnanthongpiwan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Mentha cordifolia Opiz ex Fresen. is one of the popular Thai kitchen herbs due to its unique aroma and benefits to human health such as helping to relieve colds, fever, motion sickness and poor digestion problems. This study aimed to specify the quality parameters of M. cordifolia dried leaves and stems with special reference to rosmarinic acid (RA) contents. The pharmacognostic specifications of leaf and stem crude drugs were investigated including microscopic cross-sectioning of leaf and stem as well as leaf constant numbers; physico-chemical contents i.e. acid-insoluble ash, total ash, loss on drying, moisture, extractive matters and volatile oil. The …

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Effect Of Social Media Model To Improve Sexual Health Literacy Among Secondary School Female Students In Southern Provinces, Thailand: A Quasi Experimental Study, Premyuda Narkarat Jan 2020

Effect Of Social Media Model To Improve Sexual Health Literacy Among Secondary School Female Students In Southern Provinces, Thailand: A Quasi Experimental Study, Premyuda Narkarat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background/Objectives: Adolescent pregnancy is one of major public health issues globally and in Thailand. Female adolescents are at high risk of sexual and reproductive health problems like unintended pregnancies, abortion, childbirth related complications including sexually transmitted diseases (STDs) and AIDS due to poor sexual health literacy (SHL). Sexual health literacy (SHL) is one of very important factors to prevent teenage pregnancy. The aim was to examine the effect of social media model to improve sexual health literacy among secondary school female students in southern provinces of Thailand. Method: This study employed a quasi-experimental research design using two groups the intervention …

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Improving Routine Immunization Coverage Through Strengthening Interpersonal Comminication Skills Of Primary Health Care Workers In Rural Local Government Areas In Kebbi State Nigeria, Saudat Abdullahi Basheer Jan 2020

Improving Routine Immunization Coverage Through Strengthening Interpersonal Comminication Skills Of Primary Health Care Workers In Rural Local Government Areas In Kebbi State Nigeria, Saudat Abdullahi Basheer

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: In 2015, Kebbi state was among the four (4) states in northwestern Nigeria that have low routine immunization performance in the country. National Nutrition and Health Survey 2015 report indicated that only 7.8% of the eligible children have received three doses of DPT/Penta and measles coverage was 14.7%. There was no documented research to investigate the effect of interpersonal communication skills on routine immunization services in Kebbi state Nigeria. The objective of this study, therefore, was to examine the effect of vaccination education on improving mothers' knowledge and uptake of routine immunization services among children in the rural LGAs …

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