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2020

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Effect Of Peak Plantar Presure On Plantar Corn Size, Milintorn Wongchinchai Jan 2020

Effect Of Peak Plantar Presure On Plantar Corn Size, Milintorn Wongchinchai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Corn and callus are one of the most common problems faced by dermatologists in dermatology clinic. Repeated local irritation to plantar skin results in the thickening of traumatized skin. Corn and callus are often overlooked, and this becomes longstanding problem causing pain when walking and standing up. There is no study explore the correlation between plantar pressure and size of corn. Objectives: To explore the correlation between peak plantar pressure and size of corn Materials and methods: 30 participants with plantar corn were recruited in this study. Their plantar corns were measured in millimetre using a dermoscope. Each participant …

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Effect Of The Robotic-Assisted Gait Training Device (Welwalk®) Plus Physiotherapy In Improving The Ambulatory Function In Sub-Acute Hemiplegic Stroke Patients: Assessor-Blinded, Randomized Controlled Trial, Natapatchakrid Thimabut Jan 2020

Effect Of The Robotic-Assisted Gait Training Device (Welwalk®) Plus Physiotherapy In Improving The Ambulatory Function In Sub-Acute Hemiplegic Stroke Patients: Assessor-Blinded, Randomized Controlled Trial, Natapatchakrid Thimabut

Chulalongkorn University Theses and Dissertations (Chula ETD)

Over the last decades, the effectiveness of robot-assisted gait training devices has been extensively studied. Welwalk® has been developed to support ambulatory functions in stroke patients based on motor learning theory. Objective: To investigate the effects of Welwalk® plus physiotherapy versus physiotherapy alone, in improving ambulatory function in subacute stroke patients with hemiplegia. Methods: The study was an assessor-blinded, randomized controlled trial. Twenty-six subacute stroke patients with hemiplegia were randomized and allocated into either the Welwalk group or control. All patients received 30 training sessions (5 days/week for six weeks) which included standard physiotherapy treatment (60 min) and ambulation training …

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Modelling Of Cholangiocarcinogenesis By Using Pluripotent Stem Cell, Natthida Kittimawikrom Jan 2020

Modelling Of Cholangiocarcinogenesis By Using Pluripotent Stem Cell, Natthida Kittimawikrom

Chulalongkorn University Theses and Dissertations (Chula ETD)

The exome sequencing study of cholangiocarcinoma (CCA) revealed SMAD4 mutation was frequently observed. The role of SMAD4 to cholangiocarcinogenesis as well as cell origin of CCA are not fully understand. According to current CCA model including cell lines and animal models, it still limited in resembling human cells and early event during carcinogenesis. The objective of this study was to study the role of SMAD4 signaling disruption in cholangiocyte progenitors. To clarify these questions, we used induced pluripotent stem cells (iPSCs) to differentiate into cholangiocyte organoids by using growth factors induction in this study. The result demonstrated that cholangiocyte organoids …

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Population Pharmacokinetics Of Intravenous Colistin In Pediatrics (Poppicop Study), Noppadol Wacharachaisurapol Jan 2020

Population Pharmacokinetics Of Intravenous Colistin In Pediatrics (Poppicop Study), Noppadol Wacharachaisurapol

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Colistin use in pediatrics is surging in line with the increase of multidrug-resistant Gram-negative bacteria (MDR-GNB). However, the appropriate dose is uncertain owing to the lack of pharmacokinetics data. In this study, we aimed to characterize the pharmacokinetic parameters of colistin in pediatric patients, identify the factors influencing the pharmacokinetic parameters, and propose optimal dosage regimens. Methods: A prospective, multicenter, population pharmacokinetic (PPK) study was conducted. Serial blood samples were obtained from patients after receiving the standard colistin recommended dose of 5 mg of colistin base activity (CBA)/kg/day. Plasma colistin concentrations were measured. Data were pooled from this study …

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Is Add-On Budesonide-Impregnated Nasal Dressing Useful Following Endoscopic Sinus Surgery With Perioperative Oral Steroid?, Onusa Taweewuthisub Jan 2020

Is Add-On Budesonide-Impregnated Nasal Dressing Useful Following Endoscopic Sinus Surgery With Perioperative Oral Steroid?, Onusa Taweewuthisub

Chulalongkorn University Theses and Dissertations (Chula ETD)

Some chronic rhinosinusitis with nasal polyps patients undergoing endoscopic sinus surgery (ESS) have unfavorable results despite proper postoperative treatments including oral and topical steroids. Steroid-impregnated absorbable nasal dressing has been shown to improve outcomes of the surgery. In some clinical practices, budesonide-impregnated nasal dressing is used together with perioperative oral steroid but the additional benefits of it are still unknown. This study aims to determine whether budesonide-impregnated nasal dressing had any benefits following ESS when a short course of oral steroid was given in perioperative period. This is a prospective, double-blinded, within person randomized, placebo-controlled study conducted in tertiary care …

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Identification Of Genetic And Antigenic Variation And Evolution Pattern Among Influenza A And B Viruses In Thailand, Nungruthai Suntronwong Jan 2020

Identification Of Genetic And Antigenic Variation And Evolution Pattern Among Influenza A And B Viruses In Thailand, Nungruthai Suntronwong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Seasonal influenza viruses commonly cause respiratory disease and have a considerable impact on public health threats which annually estimates 3 to 5 million cases of severe illness worldwide. The triggering of the seasonal influenza epidemic results from a complex interplay between viral, host and external factors such as climate. Although vaccination is an effective tool for influenza prevention and its complications, the composition of vaccine strain has been changed every year due to influenza constantly evolving. Here, we aim to examine the association between influenza activity and local climate factors, host immunity, genetic and antigenic variation and evolution pattern among …

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Circulating-Tumor Dna And Cancer-Induced Gene Expression As Novel Liquid Biomarkers Of Liver Cancers, Pattapon Kunadirek Jan 2020

Circulating-Tumor Dna And Cancer-Induced Gene Expression As Novel Liquid Biomarkers Of Liver Cancers, Pattapon Kunadirek

Chulalongkorn University Theses and Dissertations (Chula ETD)

Liver cancer is one of the most cancer-related mortality with high incidence worldwide. Hepatocellular carcinoma (HCC) is the most common liver cancer type. Currently, Liquid biopsy is known as a non-invasive biomarker tool that specifically represents tumor appearance, leading to improved patient outcomes. Therefore, the novel biomarkers of liquid biopsy in Thai HCC patients are still unexplored and needed for precision medicine. The main aims of this study were First, to explore genetic profiles from liquid biopsies of circulating cell-free DNA (cfDNA) and peripheral blood mononuclear cells (PBMCs) using next-generation sequencing (NGS) and identify novel biomarkers for HCC from these …

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Improve Customer Experience By Introducing Coach Knowledge Assessment (Cka) Preparation Class: Case Study Thailand Coaching Institute, Thipsupang Sanjariyapipu Jan 2020

Improve Customer Experience By Introducing Coach Knowledge Assessment (Cka) Preparation Class: Case Study Thailand Coaching Institute, Thipsupang Sanjariyapipu

Chulalongkorn University Theses and Dissertations (Chula ETD)

From problem identification process in participants' perspective, the study found two major pain points: poor exam time management based on skill and speed; and concern of language, in coach knowledge assessment (CKA) experience. Therefore, the focus of this study would be improving ICF coach mentoring program for ACC to improve experience of participants who will take coach knowledge assessment (CKA). The key objective of this research is to improve customer experience by introducing coach knowledge assessment (CKA) preparation class: case study Thailand coaching institute. From the problem identification process, the proposed solution from literature review and expert's suggestion is coach …

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A Topical Eye Drop Versus Intra-Meibomian Gland Injection Of Bevacizumab For Meibomian Gland Dysfunction Patients., Chitchanok Tantipat Jan 2020

A Topical Eye Drop Versus Intra-Meibomian Gland Injection Of Bevacizumab For Meibomian Gland Dysfunction Patients., Chitchanok Tantipat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Purpose: To compare the efficacy and safety of topical bevacizumab eye drop versus intra-meibomian gland injection of bevacizumab when used with the standard lid hygiene in meibomian gland dysfunction (MGD) patients. Methods: 60 eyes of 30 MGD patients with lid margin telangiectasia were randomized to receive 0.05% bevacizumab eye drop or single 2.5% intra-meibomian gland bevacizumab injection plus standard lid hygiene. The primary outcomes were telangiectasia grading and the computerized lid margin neovascularized area (LMNA). The secondary outcomes were the ocular surface disease index (OSDI) score, corneal staining, meibomian gland quality, meiboscore, conjunctival redness, fluorescein break up time (FBUT), noninvasive …

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Vaginal Atrophy Treatment Using Microablative Fractional Carbon Dioxide Laser: A Randomized Patient And Evaluator-Blinded Sham-Controlled Trial, Purim Ruanphoo Jan 2020

Vaginal Atrophy Treatment Using Microablative Fractional Carbon Dioxide Laser: A Randomized Patient And Evaluator-Blinded Sham-Controlled Trial, Purim Ruanphoo

Chulalongkorn University Theses and Dissertations (Chula ETD)

Introduction: In recent years, microablative fractional carbon dioxide (CO2) laser becomes popular in treatment of vaginal symptoms including vaginal atrophy. This study aimed to evaluate efficacy of vaginal CO2 laser in treatment of vaginal atrophy, compared to the sham procedure. Methods: Between June 2016 and May 2017, postmenopausal women with moderate to severe intensity of any symptoms of vaginal atrophy were invited to the study. A total of 88 women were randomized for treatment with vaginal CO2 laser or sham procedure every 4 weeks for 3 sessions. The participants were blinded to the intervention they received. The operator was also …

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Factors Related To Health-Related Quality Of Life In Patients With Acute Coronary Syndrome In West Java, Indonesia, Haerul Imam Jan 2020

Factors Related To Health-Related Quality Of Life In Patients With Acute Coronary Syndrome In West Java, Indonesia, Haerul Imam

Chulalongkorn University Theses and Dissertations (Chula ETD)

This descriptive study aimed to examine the relationship between age, self-efficacy, functional status, pain, dyspnea, social support, and health-related quality of life in patients with acute coronary syndrome in west java, Indonesia. The participants were 186 patients who has acute coronary syndrome or history of acute coronary syndrome visited cardiovascular outpatient clinic in the main national public hospital type A in west java province, Indonesia. The instruments used for data collection were Demographic Questionnaire, General Self-efficacy Scale, Seattle Angina Questionnaire, Rose Questionnaire for Angina, Rose Dyspnea Questionnaire, ENRICH Social Support, and MacNew Health Related Quality of life. These instruments were …

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A Causal Model Of Functional Status Among Persons With Liver Cirrhosis, Surachai Maninet Jan 2020

A Causal Model Of Functional Status Among Persons With Liver Cirrhosis, Surachai Maninet

Chulalongkorn University Theses and Dissertations (Chula ETD)

This cross-sectional correlation study aimed to develop and test a causal relationship among alcohol consumption, illness perception, social support, fatigue, and functional status among persons with liver cirrhosis. The hypothesized model was constructed based on the theory of unpleasant symptoms and the review of the literature. A stratified three-stage random sampling approach was utilized to recruit 400 persons with liver cirrhosis aged 40 years old and older who visited four hospitals from three regions of Thailand. Research instruments consisted of the demographic data form, Alcohol Use Disorders Identification Test Consumption, Brief Illness Perception Questionnaire, Multidimensional Scale of Perceived Social Support, …

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A Comparative Study Of Financial Literacy Between The Eu And Thailand. What Can Thailand Learn From The Eu?, Nutchapat Siripattananuntakul Jan 2020

A Comparative Study Of Financial Literacy Between The Eu And Thailand. What Can Thailand Learn From The Eu?, Nutchapat Siripattananuntakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Financial literacy is a key factor in promoting economic stability. In a situation where the world is changing rapidly, financial literacy is essential in various contexts. Nowadays, many Thai retired individuals face an increase in debt burden, and they do not have enough money for living after retirement. As the researcher is a Thai nationality, the researcher aspires to contribute to Thailand's financial literacy. Pursuing Master of Arts in European Studies have led the researcher to develop an interest in comparing the financial skills of Thais and Europeans. The objective of this study is to compare the financial literacy between …

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The End Of Homelessness Through Policies And Implementations : Case Studies Of Finland And Ireland, Rapee Tapta Jan 2020

The End Of Homelessness Through Policies And Implementations : Case Studies Of Finland And Ireland, Rapee Tapta

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objectives of this research are 1) To study the homelessness situation in Finland and Ireland 2) To describe what methods Finland and Ireland take into action to reduce homelessness 3) To compare the performance of Finland and Ireland, by collecting data from the documents, government's reports, annual reports, and related research—focusing on public policies, strategies and implementations of both Finland and Ireland from 2018 to 2021, by using thematic analysis method to analyze the date. The results of the research can divide into three topics. First, the number of homelessness in Finland and Ireland reduced satisfactorily, especially in Ireland …

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Influence Of Mixed Anionic-Nonionic Surfactants On Methane Hydrate Formation : Suppression Of Foam Formation, Chakorn Viriyakul Jan 2020

Influence Of Mixed Anionic-Nonionic Surfactants On Methane Hydrate Formation : Suppression Of Foam Formation, Chakorn Viriyakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Solidified natural gas (SNG) via clathrate hydrate is a new technology for natural gas storage with high energy content per unit volume, extremely safe, and ease to recover. Although SNG has several advantages, its limitation is low rate of hydrate formation. Sodium dodecyl sulfate (SDS) is well known as a kinetic promoter used to increase the hydrate formation rate. However, using SDS resulted in a large amount of foam during gas recovery. In order to alleviate this problem, mixtures of SDS with nonionic surfactants were investigated. Polyoxyethylene (n) lauryl ether (EO₃ and EO₅) and alkyl poly glycol (APG) were mixed …

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Communist "Normal" Life: The Criticism Of Daily Life Under A Totalitarian Regime, Rawee Archewa Jan 2020

Communist "Normal" Life: The Criticism Of Daily Life Under A Totalitarian Regime, Rawee Archewa

Chulalongkorn University Theses and Dissertations (Chula ETD)

The communist regime in Eastern Europe came after the end of Second World War by promoting the equality of people. The difference between West and East with two regimes obviously classified the living of people; the Western bloc emphasized on rights and freedom fostering the expansion of consumerist ideology. Consequently, the economic in the West developed, followed by the prosperity and well-being of people. In contrast to the Eastern bloc, it was controlled by the state and the evidences showed that the communist leaders could not serve the people's wants and needs. While the communist state created their enormous and …

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Factors Predicting Nutritional Scores In Hiv-Infected Elder Receiving Antiretroviral Therapy In Thailand, Daylia Thet Jan 2020

Factors Predicting Nutritional Scores In Hiv-Infected Elder Receiving Antiretroviral Therapy In Thailand, Daylia Thet

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: (1) To compare means of nutritional scores and means of depression scores from 2016 and 2020 (2) To investigate relationship between nutritional scores and depression scores (3) To establish nutritional score prediction model. Methodology: A longitudinal retrospective survey study was performed. Population were human immunodeficiency virus (HIV)-infected Thai elderly patients aged 50 years and above who were receiving HIV care and had previously participated in the aging cohort study conducted from March 2016 to April 2017 at the HIV-NAT Center, Bangkok, Thailand. Sample size for multiple regression analysis is calculated as 15 cases per 1 independent variable. This study …

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Effects Of Prenatal Methamphetamine Exposure On Learning And Memory And Synaptogenesis In Mouse Hippocampus, Hattaya Benya-Aphikul Jan 2020

Effects Of Prenatal Methamphetamine Exposure On Learning And Memory And Synaptogenesis In Mouse Hippocampus, Hattaya Benya-Aphikul

Chulalongkorn University Theses and Dissertations (Chula ETD)

The dynamic processes of brain development during perinatal period are vulnerable to neurotoxic insults leading to changes in brain structure and functions. Hippocampus plays an important role in learning and memory. Hippocampal formation can be influenced by substance used during brain developmental processes including neuron differentiation and synaptogenesis. Brain-derived neurotrophic factor (BDNF) regulates neuron development and neuroplasticity via its receptor TrkB. Methamphetamine (MA) abused and the risk of MA exposed during pregnancy have increased recently. The present study aimed to elucidate the effects of prenatal MA exposure on learning and memory. Prenatal effects of MA on neuronal morphology and synaptogenesis, …

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Impact Of Maximum Prescription Length Supply Policy On Patient Medication Adherence, Health And Economic Outcomes, Inthorn Jarujumrus Jan 2020

Impact Of Maximum Prescription Length Supply Policy On Patient Medication Adherence, Health And Economic Outcomes, Inthorn Jarujumrus

Chulalongkorn University Theses and Dissertations (Chula ETD)

In February 2016, Phramongkutklao hospital has implemented Extended Dispensing Policy (EDP), which increasing prescription length from 30-day to 90-day, with the purpose to increase adherence of patient to their medication prescribed. The objectives of this study were to determine the effects of the increasing in maximum prescription refill length from 30-day to 90-day on medication adherence, clinical outcomes such as HbA1c level and cholesterol level, economic outcomes including total healthcare costs, hospitalization costs, and total medication costs among diabetes and dyslipidemia patients in the Phramongkutklao hospital. This study is a quasi-experiment, pre-post, using a retrospective database from a hospital between …

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Reporting Of Adverse Drug Event By Consumers To Community Pharmacists In Thailand, Jirunya Assanee Jan 2020

Reporting Of Adverse Drug Event By Consumers To Community Pharmacists In Thailand, Jirunya Assanee

Chulalongkorn University Theses and Dissertations (Chula ETD)

No abstract provided.

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Investigation Of Cytotoxic Activity Of Full-Length And Truncated Colicin N On Human Cancer Cells, Methawee Duangkaew Jan 2020

Investigation Of Cytotoxic Activity Of Full-Length And Truncated Colicin N On Human Cancer Cells, Methawee Duangkaew

Chulalongkorn University Theses and Dissertations (Chula ETD)

Bacteria, exposed to stress from the environment or competition, release toxins called bacteriocins. Bacteriocins are classified by their mode of cytotoxicity such as pore former, endonuclease, etc. Colicins are the member of bacteriocins produced by Escherichia coli (E.coli). Among several types of colicins cytotoxicity, Pore-forming colicins has been reported in both bacteria and various type of cancer cells. Colicin N is also a pore-forming colicin and the anticancer activity of colicin N has not been extensively reported. Here we examined the cytotoxic effects of colicin N and its domain on cancer cells. The expression and purification of recombinant full-length and …

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Chemical Constituents With Alpha-Glucosidase Inhibitory Activity From Dendrobium Braianense And Dendrobium Kentrophyllum, Mia Indria Permatasari Jan 2020

Chemical Constituents With Alpha-Glucosidase Inhibitory Activity From Dendrobium Braianense And Dendrobium Kentrophyllum, Mia Indria Permatasari

Chulalongkorn University Theses and Dissertations (Chula ETD)

To investigate the phytochemicals of the entire plants of Dendrobium braianense brought about in the isolation of three bibenzyls, which included chrysotoxin, moscatilin and gigantol. From the whole plant of D. kentrophyllum three flavonoids, namely, quercetin, kaempferol and rutin were isolated, the structures of which were decided by means of analysis of spectroscopic data to compare the values already reported. They were assessed for their alpha-glucosidase inhibitory activity. Gigantol, quercetin and kaempferolwere found to exhibit strong alpha-glucosidase inhibitory activity when compared with the positive control acarbose, while chrysotoxin, moscatilin and rutin were devoid of activity.

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Analysis Of Pharmaceutical Inventory Management In A State Hospital In Myanmar, Mya Pann Thazin Jan 2020

Analysis Of Pharmaceutical Inventory Management In A State Hospital In Myanmar, Mya Pann Thazin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Inventory management (IM) analysis in a state-level hospital pharmacy of Myanmar was done by using qualitative and quantitative analysis to classify the drug categories that require different levels of management control. Workflow analysis was qualitatively conducted using in-depth interviews of pharmacists. The annual expenditure consumed on each drug of pharmacy for the years 2016 and 2017 was analyzed and application of ABC, VEN, ABC-VEN matrix analysis was performed. The study showed a lack of classification for drug procurement, monitoring, and reporting. There was a lack of appropriate communication between hospital and central procurement, shortage of pharmacists, lack of training about …

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Development Of Hyaluronic Acid-Based Nanogel Platform For Improved Stability And Polyvalent Ligand Display Of Poly(I:C) As An Effective Immunostimulatory Adjuvant In Cancer Immunotherapy, Nararat Kotcharat Jan 2020

Development Of Hyaluronic Acid-Based Nanogel Platform For Improved Stability And Polyvalent Ligand Display Of Poly(I:C) As An Effective Immunostimulatory Adjuvant In Cancer Immunotherapy, Nararat Kotcharat

Chulalongkorn University Theses and Dissertations (Chula ETD)

The aim of this research was to develop a nanogel formulation-based on modified natural polymer, hyaluronic acid (HA), as a biodegradable material for adjuvant delivery. Polyinosinic:polycytidylic acid (poly(I:C)) have been approved by FDA as a promising adjuvant candidate for the TLR3 (Toll-Like Receptor 3) activation. However, it suffers from being poor stability and is subjected to rapid enzymatic hydrolysis in serum, so that it requires high administered dose leading to adverse effects. To augment the adjuvant stability and protection from the degradation, the nano-particulate carriers were herein designed with self-assembly of HA scaffold grafted with poly (N-isopropylacrylamide), or pNIPAM. The …

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Comparison Of Area Under The Curves For Vancomycin From One- And Two-Compartment Models Using Sparse Data, Nyein Hsu Maung Jan 2020

Comparison Of Area Under The Curves For Vancomycin From One- And Two-Compartment Models Using Sparse Data, Nyein Hsu Maung

Chulalongkorn University Theses and Dissertations (Chula ETD)

Vancomycin pharmacokinetics has been described by 1- and 2-compartment models. One-compartment models built from routine monitoring data, which were mainly trough samples, are commonly used to predict area under the curves (AUC), the useful indicator for vancomycin efficacy. The question stands whether AUCs from 1-compartment models with sparse data can sufficiently represent the true AUC. This study aimed to compare AUCs from 1- and 2-compartment models using sparse data. A previously published model was used to simulate full individual profiles for 100 patients. From these data, the reference AUC (AUCref) was calculated and two depleted datasets (trough-only and peak-trough) were …

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Development Of Recombinant Human Epidermal Growth Factor Production In Nicotiana Benthamiana, Oranicha Hanittinan Jan 2020

Development Of Recombinant Human Epidermal Growth Factor Production In Nicotiana Benthamiana, Oranicha Hanittinan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Human epidermal growth factor (hEGF) is a short polypeptide that has gained clinical importance in the recent decade for wound healing. Currently, plant-based expression system is considered as an alternative viable platform for low-cost recombinant protein production. Hence, this study aims to produce hEGF in Nicotiana benthamiana plants via., transient expression using a geminiviral vector. The hEGF gene constructs were designed into six different constructs. The optimal expression was observed from the construct targeting the endoplasmic reticulum with C-terminal histidine tag at the yield level up to 15.695 µg/g LFW or 0.499% TSP. The plant-produced hEGF was purified by using …

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Effect Of Dietary Advice On The Components Of Metabolic Syndrome In Hiv/Aids Patients With Metabolic Syndrome, Patcharee Ketchaleaw Jan 2020

Effect Of Dietary Advice On The Components Of Metabolic Syndrome In Hiv/Aids Patients With Metabolic Syndrome, Patcharee Ketchaleaw

Chulalongkorn University Theses and Dissertations (Chula ETD)

Metabolic syndrome is a complication found in HIV/AIDs patients. The patients with metabolic syndrome had increased risk of cardiovascular disease. An appropriate dietary advice may help ameliorate this problem. This study aimed to investigate the effect of dietary advice on components of metabolic syndrome including anthropometric parameters, lipid profiles, fasting blood sugar, and blood pressure in the HIV/AIDs with metabolic syndrome who were on highly active antiretroviral therapy. This study was a randomized controlled trial. Sixty participants were randomly assigned into an intervention group (n = 30) and a control group (n = 30). All patients received the advice with …

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Pharmacokinetic And Metabolomic Studies Of Standardized Extract Of Centella Asiatica (Eca 233) Capsule In Thai Healthy Volunteers, Phanit Songvut Jan 2020

Pharmacokinetic And Metabolomic Studies Of Standardized Extract Of Centella Asiatica (Eca 233) Capsule In Thai Healthy Volunteers, Phanit Songvut

Chulalongkorn University Theses and Dissertations (Chula ETD)

A well-characterized standardized extract of Centella asiatica (ECa 233) being developed as a phytopharmaceutical product for human use was explored in this clinical study. The first objective of this research was to understand changes in disposition kinetics after oral administration of both the original-formula capsule and a newly-modified enhanced-dissolution capsule of ECa 233. Secondly, this study aimed to investigate alteration of human metabolomes following administration of the modified capsule of ECa 233, using an NMR-based metabolomics approach. For pharmacokinetics, the study involved a phase I clinical trial in twelve healthy Thai volunteers, who each received 250 and 500 mg of …

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Development Of Nanoparticle-In-Microsphere(Nimos) System For Oral Delivery Of Vaccine And Antibody Against Ped Virus For Swine, Rachatapan Junchay Jan 2020

Development Of Nanoparticle-In-Microsphere(Nimos) System For Oral Delivery Of Vaccine And Antibody Against Ped Virus For Swine, Rachatapan Junchay

Chulalongkorn University Theses and Dissertations (Chula ETD)

PED virus is a major barrier to the animal farming industry, and it is the main cause of the mortality of suckling piglets up to 95% by enteric infection. The 2C10 monoclonal antibody (mAb) obtained from Nicotiana benthamiana produced by transient expression was indicated as one of the potential candidates is an antibody against PEDV by oral delivery. The biologics are a new wave of pharmaceuticals and have been continuously developing, which has various benefits of low toxicity and high specificity. However, it unsuitable for use with oral drug delivery owing to limitations of the strong acidity and protease of …

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Factors Contributing To Pharmacists' Turnover Intention: A Systematic Review, Su Myat Thin Jan 2020

Factors Contributing To Pharmacists' Turnover Intention: A Systematic Review, Su Myat Thin

Chulalongkorn University Theses and Dissertations (Chula ETD)

Pharmacist turnover could negatively impact not only work efficiency, organizational performance, work productivity, and customer satisfaction but also the quality of pharmaceutical services and patient safety. The turnover intention was a core antecedent of turnover, therefore, this study aimed to systematically review the extent of pharmacists' actual turnover and their intention to leave their jobs or the pharmacy profession, and to elaborate on the factors affecting the pharmacists' turnover intention and their associations. Studies related to any factors affecting pharmacists' turnover intention in all pharmacy settings were included. The QualSyst assessment tool was used for assessing the quality of the …

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