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Articles 71551 - 71580 of 1793845
Full-Text Articles in Entire DC Network
Stabilized And Unstabilized Sampling Methods Result In Differential Fecal 16s Rrna Microbial Sequencing Results, Christopher E. Stamper, Andrew J. Hoisington, Joseph C. Ellis, Christopher A. Lowry, Lisa A. Brenner
Stabilized And Unstabilized Sampling Methods Result In Differential Fecal 16s Rrna Microbial Sequencing Results, Christopher E. Stamper, Andrew J. Hoisington, Joseph C. Ellis, Christopher A. Lowry, Lisa A. Brenner
Faculty Publications
Over the past decade, studies have been conducted to increase the understanding of associations between the fecal microbiome and human health. In conjunction, researchers have investigated the effects of study design, methods, molecular processing, and sequencing techniques. However, a lack of standardization of fecal sample collection methodology has introduced heterogeneity in sequencing results. Sources of variability include sample collection methods, storage temperatures, and transport times. Here we present 16S rRNA gene amplicon sequencing results from two sample collection methods (unstabilized sterile swab and stabilized OmniGene Gut Kits) collected from the same fecal specimens. The paired samples were collected either at …
Increasing Implementation Of The Comfortable Cafeteria Program To Promote School-Age Children’S Mental Health And Well-Being, Reinecka Mondesir, Angela Labrie Blackwell Phd, Otr
Increasing Implementation Of The Comfortable Cafeteria Program To Promote School-Age Children’S Mental Health And Well-Being, Reinecka Mondesir, Angela Labrie Blackwell Phd, Otr
Summer 2025 OTD Capstone Symposium
Every Moment Counts (EMC) is a positive mental health promotion initiative that offers several initiatives to create inclusive environments that support student participation and emotional well-being throughout the school day. Comfortable Cafeteria, part of EMC, fosters positive mealtime experiences supporting peer interaction, emotional regulation, and inclusion. Many SBOT practitioners lack the resources to implement Comfortable Cafeteria, despite its benefits. This capstone project addresses the need for practical tools to help school-based occupational therapy (SBOT) practitioners integrate the Comfortable Cafeteria program into daily practice. Using the Multi-Tiered System of Supports (MTSS) framework, the project developed and disseminated an interactive, evidence-based video …
Operative Trends In Endovascular And Open Procedures Among Vascular Fellows, Jin Park, Nicola Habash, Dawn Salvatore, Michael Nooromid, Paul J. Dimuzio, Babak Abai
Operative Trends In Endovascular And Open Procedures Among Vascular Fellows, Jin Park, Nicola Habash, Dawn Salvatore, Michael Nooromid, Paul J. Dimuzio, Babak Abai
Department of Surgery Faculty Papers
Objective: Over the past decade, there has been a growing adoption of endovascular approaches for treating vascular pathologies. This shift toward minimally invasive techniques has raised concerns about declining open surgical case volumes for vascular surgery fellows, particularly in procedures such as aortic aneurysm repair. This study aimed to analyze trends in both open and endovascular case volumes across major vascular procedure categories, including aortic aneurysm, lower extremity arterial disease, abdominal occlusive disease, and cerebrovascular disease, among graduating vascular surgery fellows. Methods: National case log data from the Accreditation Council for Graduate Medical Education were collected for 5 + 2 …
Clinical Outcomes Following Endoscopic Carpal Tunnel Release With The Arthrex Nanoscopic Release System-A Single Surgeon Experience, Sina Ramtin, Asif M. Ilyas
Clinical Outcomes Following Endoscopic Carpal Tunnel Release With The Arthrex Nanoscopic Release System-A Single Surgeon Experience, Sina Ramtin, Asif M. Ilyas
Department of Orthopaedic Surgery Faculty Papers
PURPOSE: Endoscopic carpal tunnel release (ECTR) is a minimally invasive alternative to open release, offering faster recovery and reduced postoperative discomfort. The Arthrex NanoScopic ECTR system, a novel single-use device using chip-on-tip digital imaging and designed for use under local anesthesia without arthroscopic equipment, may further streamline care and expand surgical access.
METHODS: A retrospective review was conducted of the first 50 consecutive ECTR procedures performed using the Arthrex NanoScopic system by a single hand fellowship-trained hand surgeon. All procedures were completed under wide-awake local anesthesia no tourniquet technique in an outpatient surgical center. Outcomes included operative times, adverse events, …
Ai At Work, Algorithmic Bosses, And The Ambivalence Of Automation, Antonio Aloisi, Valerio De Stefano
Ai At Work, Algorithmic Bosses, And The Ambivalence Of Automation, Antonio Aloisi, Valerio De Stefano
All Papers
This chapter revisits a foundational question (“what do bosses do?”) to explore how artificial intelligence (AI) is reshaping power dynamics in the workplace. Far from neutral tools of optimisation, algorithmic systems increasingly amplify managerial prerogatives, embedding them into automated processes that are difficult to scrutinise or contest. These developments give rise to a paradox: managers and workers are simultaneously augmented and disempowered, caught in systems that intensify control while eroding autonomy. Drawing on legal, organisational, and regulatory perspectives, we argue that existing safeguards, ranging from data protection rights to information and consultation, are ill-equipped to confront this shift. The chapter …
Butte Priority Soils Operable Unit (Bpsou) Draft Final Reclamation Improvement Sites Field Sampling And Investigation Plan (Fsp): Bres No. 18 – Walkerville Ballfield, Mike Mcanulty
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Implementation Of A Forensic Ancestry Inference Indel Panel, Jacqueline Molina
Implementation Of A Forensic Ancestry Inference Indel Panel, Jacqueline Molina
Student Theses
Ancestry-informative markers (AIMs) are genetic variants that exhibit significant frequency differences between populations, making them valuable tools for inferring biogeographical ancestry in forensic investigations. Insertion/deletion polymorphisms (INDELs) offer particular advantages for degraded forensic samples due to their short amplicon sizes and binary allelic nature. As forensic laboratories adopt newer instrumentation, validation of established assays becomes critical to ensure analytical continuity and reliability. This study evaluated the comparative performance of the SeqStudio™ Genetic Analyzer in detecting a 46 AIMs INDEL multiplex panel, previously established with the ABI 3130 Genetic Analyzer. Four commercial blood samples were analyzed using both platforms to assess …
Implementing A Delirium Risk Assessment Protocol For Older Adults To Reduce Post-Operative Delirium, Toni-Ann Thompson
Implementing A Delirium Risk Assessment Protocol For Older Adults To Reduce Post-Operative Delirium, Toni-Ann Thompson
Doctor of Nursing Practice Final Project Abstract
PURPOSE
This quality improvement project aimed to reduce post-operative delirium (POD) in patients aged 65 years and older in a post-anesthesia care unit (PACU) through the implementation of the Confusion Assessment Method (CAM) tool.
BACKGROUND
POD is a significant issue in the PACU, especially among older adults. POD can increase the length of stay in the PACU and hospital, and also increase rates of morbidity and mortality. Prior to this QI project, there was no standardized test being used to screen patients.
METHOLOGY
The Plan-Do-Study-Act (PDSA) cycle was used throughout the implementation of the confusion assessment tool to guide quality …
Adherence To Inhaled Corticosteroid Medications After An Asthma Exacerbation And The Risk Of Subsequent Exacerbations, Mina Khezrian, Marjan Kerkhof, Tham T Le, Tim Harrison, Tianshi David Wu, Bill Cook, Jonatan Hedberg, Kirsty Rhodes, Nicole Zubizarreta, Joshua Enxing, Trung N Tran
Adherence To Inhaled Corticosteroid Medications After An Asthma Exacerbation And The Risk Of Subsequent Exacerbations, Mina Khezrian, Marjan Kerkhof, Tham T Le, Tim Harrison, Tianshi David Wu, Bill Cook, Jonatan Hedberg, Kirsty Rhodes, Nicole Zubizarreta, Joshua Enxing, Trung N Tran
Faculty, Staff and Students Publications
Background: Data on the duration of improved adherence to controller medications after an exacerbation and its impact on asthma outcomes are inconsistent.
Objective: To describe levels and changes in adherence to inhaled corticosteroid (ICS)-containing medication after a severe exacerbation and the association with future exacerbation risk.
Methods: This retrospective cohort study used data from Optum's deidentified Clinformatics Data Mart Database (October 2015-December 2023). Patients with asthma, 1 or more severe exacerbations, and adherence to ICS-containing therapy (proportion of days covered [PDC]) of less than 80% in the 3 months before an exacerbation were included. Primary and secondary end points were …
Lsu-Crescentcare Sexual Health Center: An Inter-Organizational Partnership Initiative To Improve Access To Sexual Health Services In New Orleans, Louisiana, United States, Stephanie N. Taylor, Rebecca A. Lillis, Ronald D. Wilcox, Laura Damioli, David H. Martin, Alice Riener, Julio E. Figueroa, M. Jacques Nsuami
Lsu-Crescentcare Sexual Health Center: An Inter-Organizational Partnership Initiative To Improve Access To Sexual Health Services In New Orleans, Louisiana, United States, Stephanie N. Taylor, Rebecca A. Lillis, Ronald D. Wilcox, Laura Damioli, David H. Martin, Alice Riener, Julio E. Figueroa, M. Jacques Nsuami
School of Medicine Faculty Publications
Objectives: To describe a partnership between CrescentCare and Louisiana State University (LSU) School of Medicine that created a new Sexual Health Clinic in New Orleans, and to assess the health services that patients sought and received at the new clinic in the opening months of its creation. Methods: When the new clinic opened, signs were posted on New Orleans streets, flyers were placed in selected emergency rooms and healthcare facilities, radio and bus stop advertisements were purchased, and the CrescentCare website was updated with the addition of a page for the new clinic. The new clinic opened on 15 June …
What If The Swans Wreaking Havoc In Supply Chains Are Grey Not Black?, Tony N.K. Lynch, Adrian E. Coronado Mondragon, Joo Y. Jung
What If The Swans Wreaking Havoc In Supply Chains Are Grey Not Black?, Tony N.K. Lynch, Adrian E. Coronado Mondragon, Joo Y. Jung
Management Faculty Publications
Grey Swan is a relatively new construct that has not been adequately operationalised in supply chain management research. This work provides a supply chain management explanation and perspective on Grey Swans by distinguishing their characteristics relative to their more inconspicuous kindred, the Black Swans. Predictability and consequences are used to differentiate between the types of risk represented by black and grey swan events, as these are precursors to a set of descriptive and prescriptive (normative) views resulting from two pilot studies. Pilot studies were conducted to establish the validity and reliability of four types of supply chain disruptions comprising: labour …
An Assessment Of Basic Needs Insecurities In Grand Valley State University Residence Halls, Matthew Bristol
An Assessment Of Basic Needs Insecurities In Grand Valley State University Residence Halls, Matthew Bristol
Masters Theses
Basic needs insecurity scholarship in higher education consistently highlights the need to provide more and better support to students. Little research has been done to address basic needs insecurity in residence halls, and this study is the first to use the #RealCollege survey to evaluate basic needs insecurity among residential students. I use the results of the survey tell the story of what it is like for Grand Valley State University students to face basic needs insecurity while living on campus, to assess what resources participants use to secure their basic needs and offer recommendations for improved support offerings to …
Comparative Analysis Of Codes Of Ethical Conduct And Professionalism In Engineering And Project Management Associations, Valarie Denney, James W. Marion
Comparative Analysis Of Codes Of Ethical Conduct And Professionalism In Engineering And Project Management Associations, Valarie Denney, James W. Marion
Publications
This research details the similarities and differences in moral values and perspective from 15 engineering and project management association codes of conduct and professionalism. The methodology uses text mining of selected codes counting and summarizing keywords, evaluating document similarities through cosine similarity, and assessing the influence of various ethical schools of thought. Key findings reveal differences in the emphasis of core ethical values like fairness, honesty, and responsibility across different associations. This research is important for engineering and project management professionals to purposefully develop and evolve codes of ethics and professional development to enhance integrity, accountability, and ethical decision-making.
The Impact Of Family Violence On Bullying Behaviour Among Secondary School Students In Ilorin Metropolis, Oyedotun Dolapo Ilori, Patrick O. Akerele, Ifeoluwa Blessing Michael
The Impact Of Family Violence On Bullying Behaviour Among Secondary School Students In Ilorin Metropolis, Oyedotun Dolapo Ilori, Patrick O. Akerele, Ifeoluwa Blessing Michael
Buletin Konseling Inovatif
Family violence remains a significant social issue with far-reaching consequences for adolescents, particularly in shaping their behavioural tendencies, including bullying. This study examines the impact of family violence on bullying behaviour among secondary school students in Ilorin Metropolis, which comprises three Local Government Areas (Ilorin South, Ilorin West, and Ilorin East). The study adopts a descriptive survey research design to assess the extent to which exposure to family violence influences students' bullying behaviours, while also considering the role of peer influence. A multi-stage sampling technique was employed to select 417 students from both public and private secondary schools in Ilorin …
School-Based Peer Mentoring Programs To Support New Teacher Retention, Denisha Logan
School-Based Peer Mentoring Programs To Support New Teacher Retention, Denisha Logan
Walden Dissertations and Doctoral Studies
An increased rate of attrition among new educators underscores the urgency of addressing the challenges faced by early career teachers. The problem addressed in this study was the high attrition rate of new teachers in middle-low-income urban schools in Maryland. Guided by Kram’s mentoring theory and Maslow’s hierarchy of needs, the purpose of this basic qualitative study was to explore the perceptions of new teachers regarding how the school-based peer mentoring program contributed to them remaining at their schools. Semistructured interviews were conducted with 10 novice teachers who had fewer than 3-years of experience teaching at the study site. Thematic …
Cardiometabolic Outcomes In The Obese African American Population With Rheumatoid Arthritis, Cecilia Jillo Walan
Cardiometabolic Outcomes In The Obese African American Population With Rheumatoid Arthritis, Cecilia Jillo Walan
Walden Dissertations and Doctoral Studies
Rheumatoid arthritis (RA) disproportionately impacts African American adults, particularly those with obesity, due to overlapping cardiometabolic risks and health care disparities. The intersection of RA, obesity, and chronic conditions such as cardiovascular disease (CVD) and hypertension underscores the need for targeted public health interventions. This study investigated the association between RA and cardiometabolic outcomes among African American adults with obesity, aiming to identify significant predictors within this high-risk population. This quantitative study employed a cross-sectional design to analyze data from the 1999–2018 National Health and Nutrition Examination Survey undergirded by the social ecological change framework with N=23644 African American adults …
Trade Association Leaders’ Successful Strategies For Increasing Racial Diversity Within Their Respective Industries, Nicole A. Singleton Norman
Trade Association Leaders’ Successful Strategies For Increasing Racial Diversity Within Their Respective Industries, Nicole A. Singleton Norman
Walden Dissertations and Doctoral Studies
In the architectural, engineering, and construction (AEC) industry, innovation thrives on diverse perspectives. Without effective diversity and inclusion strategies, AEC industry leaders may hinder innovation opportunities, which could result in reduced profitability and employee morale in a highly competitive market. Grounded in institutional theory and resource-based view theory, the purpose of this qualitative pragmatic inquiry research project was to identify and explore successful strategies AEC trade association leaders use to assist association members in enhancing their organizations’ performance through workforce diversity to increase innovation, profitability, and employee morale. Data were gathered from six participants from various AEC trade associations across …
Perspectives Of Black Male Administrators On Gaining Administrative Roles At Community And Technical Colleges, Marcusantonio Gunn
Perspectives Of Black Male Administrators On Gaining Administrative Roles At Community And Technical Colleges, Marcusantonio Gunn
Walden Dissertations and Doctoral Studies
The problem that was addressed in this study is that there is a low number of Black male administrators at community and technical colleges (CTCs) throughout the United States, despite widespread organizational practices of adopting diversity and equity policies, implementing mentoring programs, and providing professional development. The purpose of this basic qualitative study was to explore Black male administrators’ perceptions of hiring barriers and their recommendations to improve the professional pathway to employment at CTCs. Guided by critical race theory in education, data were collected through semistructured interviews with eight Black male administrators who are serving or have served in …
Lived Experiences Of Newly Graduated Social Workers Transitioning Into The Field Of Child Protective Services, Chantrese Oliver
Lived Experiences Of Newly Graduated Social Workers Transitioning Into The Field Of Child Protective Services, Chantrese Oliver
Walden Dissertations and Doctoral Studies
Lived Experiences of Newly Graduated Social Workers Transitioning Into the Field of Child Protective Services by Chantrese Oliver MPhil, Walden University, 2024 MS, Walden University, 2014 AA, National Paralegal College, 2012 BS, Fayetteville State University, 2010 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Psychology Walden University August 2025
The Lived Experiences Of Clinically Licensed Counselors During Covid-19, Deirdre F. Haynes
The Lived Experiences Of Clinically Licensed Counselors During Covid-19, Deirdre F. Haynes
Walden Dissertations and Doctoral Studies
The COVID-19 pandemic has proven to be an equal opportunity crisis. There is substantial research to better understand how individuals have reacted to crisis experiences like the COVID-19 pandemic. However, little is known about the lived experiences of clinically licensed counselors during COVID-19. This gap in the literature is important because the increase in the number of individuals seeking counseling to deal with their fears and concerns related to the COVID-19 pandemic may have put a strain on counselors that were also experiencing the effects of the COVID-19 pandemic. The purpose of this interpretative phenomenological analysis was to bridge the …
Re: Butte Priority Soils Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling And Investigation Plan (Fsp) For Ur-19 – Butte, Anaconda & Pacific Railway From Montana Street To South Arizona Avenue – Montana Street Adjacent Parcel, Mike Mcanulty
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Ribosome Deficiency Induces Salmonella Filamentation Within Host Cells, Zhihui Lyu, Cierra Wilson, Kalyn Weiss, Spencer Lewis, Kurt Fredrick, William Margolin, Jiqiang Ling
Ribosome Deficiency Induces Salmonella Filamentation Within Host Cells, Zhihui Lyu, Cierra Wilson, Kalyn Weiss, Spencer Lewis, Kurt Fredrick, William Margolin, Jiqiang Ling
Faculty, Staff and Student Publications
The ribosome is the central hub for protein synthesis and is heavily targeted by antibiotics. Ribosomal mutations, antibiotic treatment, and nutrient starvation can alter translational efficiency and lead to stressed cells. Ribosome deficiency plays a critical role in stress responses and disease progression; yet, how it affects bacteria-host interactions remains poorly understood. In this study, we show that a ribosome-deficient strain exhibits a surprising morphological change from rod shape to filamentous in Salmonella cells growing inside host macrophages. Such filamentation depends on an acidic condition within macrophages and in a defined medium mimicking macrophage conditions. Further genetic analyses revealed that …
Csf-Exosomal Mirnas And Delayed Cerebral Ischemia: Insights Into Pathophysiology But No Definitive Biomarkers, Chathathayil M Shafeeque, Devin W Mcbride, Yuanqing Yan, Hussein A Zeineddine, John P Hagen, H Alex Choi, Jude P Savarraj, Ari Dienel, Spiros L Blackburn, Peeyush Kumar Thankamani
Csf-Exosomal Mirnas And Delayed Cerebral Ischemia: Insights Into Pathophysiology But No Definitive Biomarkers, Chathathayil M Shafeeque, Devin W Mcbride, Yuanqing Yan, Hussein A Zeineddine, John P Hagen, H Alex Choi, Jude P Savarraj, Ari Dienel, Spiros L Blackburn, Peeyush Kumar Thankamani
Faculty, Staff and Student Publications
Background: Aneurysmal subarachnoid hemorrhage (aSAH) is notoriously known for its high mortality and morbidity. Approximately one-third of the patients who survive aneurysm rupture are reported to develop delayed cerebral ischemia (DCI), which contributes to a poor clinical outcome. Currently, there are no biomarkers for identifying which aSAH patients are at risk of developing DCI. We aimed to determine the feasibility of cerebrospinal fluid (CSF) exosomal microRNAs (miRNAs) for predicting DCI post-aSAH.
Methods: aSAH patients were prospectively enrolled, and CSF samples were collected at two time points (< 24 h and 72 h post-aSAH) from individuals undergoing external ventricular drainage. Exosomal miRNAs were isolated from the CSF for analysis. In the initial group of patients (discovery cohort), an exploratory analysis was conducted using a CSF panel containing 84 miRNAs, assessed by quantitative real-time PCR (RT-qPCR). Based on this analysis, 27 miRNAs were selected for further evaluation in a second group of patients (validation cohort). Among these, 10 miRNAs had previously been reported in SAH-related CSF studies, supporting their relevance for continued investigation.
Results: In this study, RT-qPCR analysis of 84 miRNAs in CSF samples from …
Reduced Computed Tomography Scan Speed Improves Alignment Errors For Patients Undergoing Thoracic Stereotactic Body Radiation Therapy, Ramaswamy Sadagopan, Rachael M Martin-Paulpeter, Christopher R Peeler, Xiaochun Wang, Paige Nitsch, Julianne M Pollard-Larkin
Reduced Computed Tomography Scan Speed Improves Alignment Errors For Patients Undergoing Thoracic Stereotactic Body Radiation Therapy, Ramaswamy Sadagopan, Rachael M Martin-Paulpeter, Christopher R Peeler, Xiaochun Wang, Paige Nitsch, Julianne M Pollard-Larkin
Faculty, Staff and Student Publications
Objectives: We investigated the performance of a slow computed tomography (CT) protocol to reduce alignment errors arising from motion when using CT-on-rail (CTOR) for image guidance for patients receiving thoracic stereotactic body radiation therapy (SBRT).
Methods: A Quasar lung phantom with a moving tumor was programmed with three breathing rates and three motion amplitudes. MIP and average 4DCT images were used for contouring and alignment, respectively. Ten CTOR images were obtained for each of the breathing rates and amplitudes, under both CT protocols. We used in-house CAT software for image guidance, centering the tumor in the lung window …
Dalbavancin For Treatment Of Staphylococcus Aureus Bacteremia: The Dots Randomized Clinical Trial, Nicholas A Turner, Toshimitsu Hamasaki, Sarah B Doernberg, Thomas P Lodise, Heather A King, Varduhi Ghazaryan, Sara E Cosgrove, Timothy C Jenkins, Catherine Liu, Shrabani Sharma, Smitha Zaharoff, Lana Wahid, Valerie J Renard, Paul Cook, Issam Raad, Ray Hachem, Anne-Marie Chaftari, Matthew Sims, Carmen Demarco, Loren G Miller, Matthew W Mccarthy, Caryn G Morse, Chris Lucasti, Graeme N Forrest, Kartikeya Cherabuddi, Christopher Polk, Tasaduq Fazili, Mark E Rupp, George R Thompson, Kami Kim, Luke Strnad, Amanda E Schnee, James A Mckinnell, Mayur Ramesh, Fernanda P Silveira, Todd P Mccarty, Todd C Lee, Emily G Mcdonald, Kristopher Paolino, Katie Wiegand, Alison Wall, Todd Riccobene, Rinal Patel, Urania Rappo, Scott Evans, Henry F Chambers, Vance G Fowler, Thomas L Holland
Dalbavancin For Treatment Of Staphylococcus Aureus Bacteremia: The Dots Randomized Clinical Trial, Nicholas A Turner, Toshimitsu Hamasaki, Sarah B Doernberg, Thomas P Lodise, Heather A King, Varduhi Ghazaryan, Sara E Cosgrove, Timothy C Jenkins, Catherine Liu, Shrabani Sharma, Smitha Zaharoff, Lana Wahid, Valerie J Renard, Paul Cook, Issam Raad, Ray Hachem, Anne-Marie Chaftari, Matthew Sims, Carmen Demarco, Loren G Miller, Matthew W Mccarthy, Caryn G Morse, Chris Lucasti, Graeme N Forrest, Kartikeya Cherabuddi, Christopher Polk, Tasaduq Fazili, Mark E Rupp, George R Thompson, Kami Kim, Luke Strnad, Amanda E Schnee, James A Mckinnell, Mayur Ramesh, Fernanda P Silveira, Todd P Mccarty, Todd C Lee, Emily G Mcdonald, Kristopher Paolino, Katie Wiegand, Alison Wall, Todd Riccobene, Rinal Patel, Urania Rappo, Scott Evans, Henry F Chambers, Vance G Fowler, Thomas L Holland
Faculty, Staff and Student Publications
Importance: Dalbavancin is a long-acting intravenous lipoglycopeptide that may be effective for treatment of complicated Staphylococcus aureus bacteremia without requiring long-term intravenous access.
Objective: To evaluate the efficacy and safety of dalbavancin vs standard therapy for completion of treatment of complicated S aureus bacteremia.
Design, setting, and participants: Open-label, assessor-masked, randomized clinical trial conducted from April 2021 to December 2023 at 23 medical centers in the US (n = 22) and Canada (n = 1). Participant follow-up lasted 70 days (180 days for participants with osteomyelitis); date of final follow-up was December 1, 2023. Hospitalized adults with complicated S aureus …
Identification Of Alkynyl Nicotinamide Hsn748 As A Ret Solvent-Front Mutant Inhibitor With Intracranial Efficacy, Ujjwol Khatri, Neetu Dayal, Kofi B Owusu, Mandeep Kaur Hunjan, Shriya Pandey, Haley Anne Harper, Carli Mcmahan, Bennett D Elzey, Tao Shen, Xueqing Hu, Kurt W Evans, Ahmed El-Sheikh, Seong Jun Jo, Frederick W Holtsberg, M Javad Aman, Funda Meric-Bernstam, Sukyung Woo, Herman O Sintim, Jie Wu
Identification Of Alkynyl Nicotinamide Hsn748 As A Ret Solvent-Front Mutant Inhibitor With Intracranial Efficacy, Ujjwol Khatri, Neetu Dayal, Kofi B Owusu, Mandeep Kaur Hunjan, Shriya Pandey, Haley Anne Harper, Carli Mcmahan, Bennett D Elzey, Tao Shen, Xueqing Hu, Kurt W Evans, Ahmed El-Sheikh, Seong Jun Jo, Frederick W Holtsberg, M Javad Aman, Funda Meric-Bernstam, Sukyung Woo, Herman O Sintim, Jie Wu
Faculty, Staff and Student Publications
RET solvent-front G810C/R/S mutations confer resistance to the currently approved RET protein tyrosine kinase inhibitors (TKIs) selpercatinib and pralsetinib. Moreover, RET fusion-positive lung adenocarcinoma frequently metastasizes to the brain. To address these challenges, it is imperative to develop a RET TKI that is effective against solvent-front mutations and exhibits intracranial activity. We synthesized alkynyl nicotinamide-based RET TKIs and tested their efficacy in cell cultures in inhibiting selpercatinib/pralsetinib-resistant RET solvent-front mutants G810C/R/S found in cancer patients, and in BaF3/KIF5B-RET(G810C) cell-derived subcutaneous and intracranial tumors in vivo. We also evaluated alkynyl nicotinamide RET TKIs in KIF5B-RET-induced lung tumors in immune competent …
Defining Treatment-Resistant Bipolar Depression: Recommendations From The Isbd Task Force, Eduard Vieta, Roger S Mcintyre, Trisha Suppes, Tamsyn E Van Rheenen, Balwinder Singh, Kamilla Woznica Miskowiak, Allan H Young, Lakshmi N Yatham, Kyooseob Ha, Michael Berk, Holly A Swartz, Chantal Henry, Maja Pantovic Stefanovic, Gerard Anmella Diaz, Aysegul Ozerdem, Wiesław J Cubała, Diego Hidalgo-Mazzei, Mauricio Tohen, Isabella Pacchiarotti, Paula Villela Nunes, Carlos Lopez-Jaramillo, Ana Gonzalez-Pinto, Paolo Brambilla, Robert Post, Jair C Soares, Michael Bauer, Ana C Andreazza, Xavier Justes Fradera, Montserrat Cosials-Lopez, Giovanna Fico
Defining Treatment-Resistant Bipolar Depression: Recommendations From The Isbd Task Force, Eduard Vieta, Roger S Mcintyre, Trisha Suppes, Tamsyn E Van Rheenen, Balwinder Singh, Kamilla Woznica Miskowiak, Allan H Young, Lakshmi N Yatham, Kyooseob Ha, Michael Berk, Holly A Swartz, Chantal Henry, Maja Pantovic Stefanovic, Gerard Anmella Diaz, Aysegul Ozerdem, Wiesław J Cubała, Diego Hidalgo-Mazzei, Mauricio Tohen, Isabella Pacchiarotti, Paula Villela Nunes, Carlos Lopez-Jaramillo, Ana Gonzalez-Pinto, Paolo Brambilla, Robert Post, Jair C Soares, Michael Bauer, Ana C Andreazza, Xavier Justes Fradera, Montserrat Cosials-Lopez, Giovanna Fico
Faculty, Staff and Student Publications
Objective: Despite the availability of approved treatments, a substantial proportion of patients with bipolar disorder experience treatment-resistant bipolar depression (TRBD), characterized by persistent depressive symptoms unresponsive to standard therapies. However, a universally accepted definition of TRBD is lacking. This consensus document, developed by the International Society for Bipolar Disorders (ISBD) Task Force on TRBD, aims to provide a standardized definition of TRBD to facilitate clinical trials, research, and treatment strategies.
Methods: The Task Force employed a literature review, clinical trials analysis, and expert consensus meetings to define TRBD.
Results: TRBD was defined as the failure to achieve a significant and …
Defining Treatment-Resistant Bipolar Depression: Recommendations From The Isbd Task Force, Eduard Vieta, Roger S Mcintyre, Trisha Suppes, Tamsyn E Van Rheenen, Balwinder Singh, Kamilla Woznica Miskowiak, Allan H Young, Lakshmi N Yatham, Kyooseob Ha, Michael Berk, Holly A Swartz, Chantal Henry, Maja Pantovic Stefanovic, Gerard Anmella Diaz, Aysegul Ozerdem, Wiesław J Cubała, Diego Hidalgo-Mazzei, Mauricio Tohen, Isabella Pacchiarotti, Paula Villela Nunes, Carlos Lopez-Jaramillo, Ana Gonzalez-Pinto, Paolo Brambilla, Robert Post, Jair C Soares, Michael Bauer, Ana C Andreazza, Xavier Justes Fradera, Montserrat Cosials-Lopez, Giovanna Fico
Defining Treatment-Resistant Bipolar Depression: Recommendations From The Isbd Task Force, Eduard Vieta, Roger S Mcintyre, Trisha Suppes, Tamsyn E Van Rheenen, Balwinder Singh, Kamilla Woznica Miskowiak, Allan H Young, Lakshmi N Yatham, Kyooseob Ha, Michael Berk, Holly A Swartz, Chantal Henry, Maja Pantovic Stefanovic, Gerard Anmella Diaz, Aysegul Ozerdem, Wiesław J Cubała, Diego Hidalgo-Mazzei, Mauricio Tohen, Isabella Pacchiarotti, Paula Villela Nunes, Carlos Lopez-Jaramillo, Ana Gonzalez-Pinto, Paolo Brambilla, Robert Post, Jair C Soares, Michael Bauer, Ana C Andreazza, Xavier Justes Fradera, Montserrat Cosials-Lopez, Giovanna Fico
Faculty, Staff and Student Publications
Objective: Despite the availability of approved treatments, a substantial proportion of patients with bipolar disorder experience treatment-resistant bipolar depression (TRBD), characterized by persistent depressive symptoms unresponsive to standard therapies. However, a universally accepted definition of TRBD is lacking. This consensus document, developed by the International Society for Bipolar Disorders (ISBD) Task Force on TRBD, aims to provide a standardized definition of TRBD to facilitate clinical trials, research, and treatment strategies.
Methods: The Task Force employed a literature review, clinical trials analysis, and expert consensus meetings to define TRBD.
Results: TRBD was defined as the failure to achieve a significant and …
An Exciting Future For Microbial Molecular Biology And Physiology, Andrew A Bridges, Leah Guthrie, Mckenzie Lehman, Elizabeth H Kellogg, Samantha Wellington Miranda, Andrew Pountain, Anthony L Shiver, Andrew Varble, Molecular Biology And Physiology Community Of The Council On Microbial Sciences, Heidi B Kaplan, Elizabeth A Shank, Gisela Storz
An Exciting Future For Microbial Molecular Biology And Physiology, Andrew A Bridges, Leah Guthrie, Mckenzie Lehman, Elizabeth H Kellogg, Samantha Wellington Miranda, Andrew Pountain, Anthony L Shiver, Andrew Varble, Molecular Biology And Physiology Community Of The Council On Microbial Sciences, Heidi B Kaplan, Elizabeth A Shank, Gisela Storz
Faculty, Staff and Student Publications
Continuous advances in technologies ranging from deep sequencing and genetic manipulation to mass spectrometry, single cell imaging, and structural biology have led to previously unimaginable advances in our understanding of microbial physiology and the molecular mechanisms underlying microbial responses in a multitude of environments. Simultaneously, these advances are revealing how much more there is to learn. At the 2024 virtual retreat of the Molecular Biology and Physiology (MBP) Community of the Council on Microbial Sciences (COMS) of the American Society for Microbiology (ASM), eight early-career investigators, along with retreat attendees, discussed some of these astounding advances, as well as the …