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2020

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Identifying Micro-Level Determinants That Influence The Transportation Network Companies (Tncs) Growth Through Analysis Of Transportation Users’ Preferences And Attitudes, Sahila Sarjana Jan 2020

Identifying Micro-Level Determinants That Influence The Transportation Network Companies (Tncs) Growth Through Analysis Of Transportation Users’ Preferences And Attitudes, Sahila Sarjana

All ETDs from UAB

In the recent years, the use of Transportation Network Companies (TNCs) such as Uber/Lyft as a mode of travel has been growing at a significant pace. Despite the rapid growth of several TNC markets, analyses of potential and actual impacts of TNCs presence on preferences and travel patterns of TNC-aware users are still very limited. Such analyses require detailed trip data which are not easily available due to privacy concerns, as well as technical and financial feasibility issues. To address some of these issues, the objective of this study was to document the factors that influence transportation users in the …

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Rna Polymerase I Elongation Kinetics: A Biochemical And Global Study Of A Cancer Therapeutic Target, Catherine Elizabeth Scull Jan 2020

Rna Polymerase I Elongation Kinetics: A Biochemical And Global Study Of A Cancer Therapeutic Target, Catherine Elizabeth Scull

All ETDs from UAB

My graduate research has focused on understanding the elongation kinetics of RNA polymerase I (Pol I), the enzyme responsible for synthesizing ribosomal RNA (rRNA), and defining how inhibition of ribosome biogenesis may be used as a cancer therapeutic strategy. Here, I have defined key biophysical features of Pol I and I have expanded the field’s understanding of Pol I elongation by: 1) characterizing the enzymatic properties of Pol I by mutational analysis of the polymerase itself, and by 2) elucidating the role of DNA sequence on Pol I arrest and nucleolytic cleavage activity. In recent years, Pol I has become …

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Assessing Contributing Factors Of Relationship Satisfaction In Polyamorous And Monogamous Relationships, Irene Kushnir Jan 2020

Assessing Contributing Factors Of Relationship Satisfaction In Polyamorous And Monogamous Relationships, Irene Kushnir

Walden Dissertations and Doctoral Studies

The purpose of this study was to analyze and compare factors contributing to relationship satisfaction in polyamorous and monogamous relationships, as measured by the Characteristics of Marriage Inventory (CHARISMA). A total of 372 participants over the age of 18 who identified as being involved in either a long-term monogamous or polyamorous relationship completed the CHARISMA questionnaire. Two multivariate analyses of variance revealed 10 out of 18 importance ratings, and 4 out of the 18 satisfactions ratings were statistically significant between relationship types. However, an analysis of variance suggested no overall difference in satisfaction between the two groups. Past research had …

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Investigation Of Drp1 Inhibition As Potential Therapy In Pesticide-Based Models Of Parkinson's Disease, Jennifer Rhea Pinnell Jan 2020

Investigation Of Drp1 Inhibition As Potential Therapy In Pesticide-Based Models Of Parkinson's Disease, Jennifer Rhea Pinnell

Other Faculty of Health Theses

In this study I explored the impact of Drp1 inhibition on pathology in two different pesticide-based models of Parkinson’s disease, and found that paraquat induced autophagy blockade in vitro, which was abrogated by inhibition of Drp1 function through siRNA knockdown or expression of the Drp1K38A dominant negative. Rotenone and paraquat are two pesticides implicated in the pathophysiology and progression of Parkinson’s disease, a hypokinetic neurodegenerative disorder which results in motor and cognitive changes in patients. Previous studies confirmed pesticide-induced loss of dopaminergic neurons in the substantia nigra pars compacta in animal models, however further research was necessary to explore the …

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Clinical Outcomes Post-Implantation Of Multifocal And Toric Intraocular Lenses, Elizabeth Martha Law Jan 2020

Clinical Outcomes Post-Implantation Of Multifocal And Toric Intraocular Lenses, Elizabeth Martha Law

Other Faculty of Health Theses

In order to increase spectacle independence following cataract surgery and intraocular lens (IOL) implantation; correction of spherical refractive error, astigmatic error and presbyopia should all be given careful consideration. There are many premium IOLs, including multifocal intraocular lenses (MIOLs) and toric intraocular lenses (TIOLs), available to surgeons. In order to select the appropriate IOL to meet a patient’s lifestyle and expectations, clinicians must fully understand the characteristics of MIOL and TIOL designs. To date, there remain unanswered questions pertaining to MIOLs and TIOLs and by rigorous comparison of such lenses, this thesis aims to address some of the gaps in …

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Development And Characterisation Of An Immunocompetent Three-Dimensional Oral Mucosal Infection Model, Samantha Gould Jan 2020

Development And Characterisation Of An Immunocompetent Three-Dimensional Oral Mucosal Infection Model, Samantha Gould

Other Faculty of Health Theses

Oral mucosal models are valuable tools for studying oral infection. Existing models have been implemented to study pathogen tissue invasion and resultant damage. These models fail to incorporate an innate immune component such as macrophages, essential for study of host response to infection. Macrophages exist within a regulatory to inflammatory polarisation spectrum, whereby the local microenvironment determines their activity, contributing to the overall behaviour of a tissue. Three-dimensional oral mucosal models were formed using primary (POK) or immortalized (HaCaT) keratinocytes seeded upon a human gingival fibroblast (HGF) embedded type-1 collagen matrix. Later, HaCaT based models (3DOMMs) were further developed to …

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A Concept Analysis Of Compassion In Healthcare Practice, Sarah Tobin Jan 2020

A Concept Analysis Of Compassion In Healthcare Practice, Sarah Tobin

Other Faculty of Health Theses

The subject of compassion is frequently discussed in healthcare literature but despite this, is potentially poorly understood and lacks consensus in definition. This study sought to clarify what exactly is meant by the term compassion in a healthcare context and how this is defined in both the literature and, crucially, by the behaviour and experience of healthcare staff and the experience of service users. In order to establish a definition of compassion the hybrid approach to concept analysis based on the method described by Schwartz-Barcott and Kim (2000) was adopted, this model combines comprehensive literature review with a fieldwork element …

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Intrinsic Control Strategies For Herpesvirus-Based Vaccine Vectors, Hujaz Ismail Abdulrazzaq Alqirbi Jan 2020

Intrinsic Control Strategies For Herpesvirus-Based Vaccine Vectors, Hujaz Ismail Abdulrazzaq Alqirbi

Other Faculty of Health Theses

Herpesvirus-based vectors have been used in vaccine strategies to target zoonotic diseases such as Ebola and human monkeypox, through eliciting a highly immunogenic response. We are investigating strategies to attenuate the virus and control its ability to replicate and persist, while maintaining its ability to elicit protective immune responses. In this project we have investigated three distinct and innovative means to provide intrinsic control of herpesvirus-based vectors. The first strategy is based on deletion of a gene essential for viral latency to modify persistence in vivo. Studies by Thirion et al have shown that the bovine herpesvirus 4 (BoHV-4) ORF73 …

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Hot Food Takeaways Around Schools: Can Fast Food Be Healthier?, Claire Louise Turbutt Jan 2020

Hot Food Takeaways Around Schools: Can Fast Food Be Healthier?, Claire Louise Turbutt

Other Faculty of Health Theses

Obesity is the greatest global health challenge facing this generation; over half of the adult population are overweight or obese. Calls for food environment interventions include recommendations for restriction or banning of new fast food retailers (FFRs). The Takeaway Toolkit was published by the Chartered Institute of Environmental Health and aimed to alter consumption of unhealthy takeaway food through reformulation and behavioural insights. A systematic review assessing evidence on FFRs in the environment around schools in the United Kingdom (UK) was completed and published. This revealed a research gap around food environment interventions. A study was designed to investigate “the …

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Understanding The Role Of Dmob4 In Postembryonic Neural Stem Cell Mitotic Reactivation, Eleanor Gonzaga Jan 2020

Understanding The Role Of Dmob4 In Postembryonic Neural Stem Cell Mitotic Reactivation, Eleanor Gonzaga

Other Faculty of Health Theses

Brain homeostasis supports cognition and neural plasticity, the brains’ ability to adapt to its environment throughout life. These processes rely on replenishment from stem cells in the brain, termed Neural Stem Cells (NSCs). In the adult brain, most NSCs exist in a quiescent state and must activate to generate new neural progeny. Understanding how NSCs balance quiescence and activation is crucial for the development of brain repair therapies. Drosophila NSCs, termed neuroblasts (NBs), are a model to study reactivation from quiescence. The Hippo and Insulin pathways were reported to promote NB quiescence and reactivation, respectively. However, the underlying mechanisms are …

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Early Hippocampal Dysfunction In A Mouse Model Of Dementia With Lewy Bodies: Mechanisms Of Cellular Dysfunction Caused By Alpha-Synuclein Accumulation, Katrina Cowan Jan 2020

Early Hippocampal Dysfunction In A Mouse Model Of Dementia With Lewy Bodies: Mechanisms Of Cellular Dysfunction Caused By Alpha-Synuclein Accumulation, Katrina Cowan

Other Faculty of Health Theses

Dementia with Lewy bodies (DLB) is a devastating neurodegenerative disease, accounting for 5% of all dementia cases, for which there is no cure. Whilst there are currently many different animal models currently available for researchers studying PD, there are comparatively fewer DLB-specific mouse models. The limited amount of effective DLB mouse models presents a significant issue in the pursuit for DLB treatment. In my project, I aim to determine the accuracy of a novel DLB-specific mouse model, focusing on changes in mitochondrial function. Additionally, I explore the role of the wild-type and a DLB-related mutation of the protein beta-synuclein on …

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Social Connectedness And Financial Independence Strategies Supporting Nonprofit Sustainability, Christopher Edmund Maylor Jan 2020

Social Connectedness And Financial Independence Strategies Supporting Nonprofit Sustainability, Christopher Edmund Maylor

Walden Dissertations and Doctoral Studies

Leaders of nonprofit organizations (NPOs) often lack strategies to ensure the sustainability of their organizations beyond initial funding, resulting in significant risk to program continuity. Grounded in social entrepreneurship theory, the purpose of this qualitative single-case study was to explore strategies used by 3 leaders of a small NPO in the southwest region of the United States. Data were collected from semistructured interviews and a review of organizational documents. Through thematic analysis, 6 social themes emerged: optimization of business strategies, income and donor growth, program cost management, funding diversification, program licensing, and public awareness of NPO programs. The contributions to …

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Advanced Glycation End Products As A Biomarker For Accelerated Ocular Ageing And Glaucoma, Leanne Smewing Jan 2020

Advanced Glycation End Products As A Biomarker For Accelerated Ocular Ageing And Glaucoma, Leanne Smewing

Other Faculty of Health Theses

Advanced glycation end products (AGEs) have a large impact on the healthy ageing population and those diagnosed with pathology. Studies have linked AGEs to glaucomatous optic neuropathy, however there is little consensus on the role AGEs play in glaucoma development. Furthermore, it is known that diet is an exogenous source of AGEs, however it is not clear how dietary AGE (dAGE) influences tissue-bound levels in the body. The overarching theme of this thesis was to assess the impact of AGE level, measured both through diet and tissue-bound levels in the skin (skin autofluoresence, SAF), on retinal vessels and the cornea …

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Epidermicin Ni01 And Human Β-Defensin 2 As Modulators Of Macrophage Subset Responses, Barbara Durante Jan 2020

Epidermicin Ni01 And Human Β-Defensin 2 As Modulators Of Macrophage Subset Responses, Barbara Durante

Other Faculty of Health Theses

Antimicrobial peptides (AMPs) and host defence peptides (HDPs) have been extensively investigated for their antimicrobial activity and evidence suggests that they can also modulate the host immune system. However, little is known about their effects on macrophages, a key cell population in inflammatory responses that mediates communication between innate and adaptive immunity. Macrophages are a pleiotropic cell population composed of different subsets that orchestrate diverse stages of inflammation with roles ranging from pro- to anti-inflammatory and thus, targets for immunomodulation in different diseases. Here, THP-1-derived M1- and M2-like cells (pro- and anti-inflammatory respectively) under stimulation of TLR4 by LPS were …

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An Examination Of Professional Support In The Life Of The Experienced Urban Primary Teacher, Sue Langford Jan 2020

An Examination Of Professional Support In The Life Of The Experienced Urban Primary Teacher, Sue Langford

School of Law, Humanities and Social Sciences Theses

The purpose of this study was to determine how experienced primary school teachers, in urban settings, can be supported in their professional lives. Teacher turnover is a challenge both here in England and internationally. Teacher turnover can be expensive for schools, disruptive for students and problematic for both the teachers who stay and for the teachers who leave. I argue that, developing a deeper understanding of how experienced primary teachers can be supported in their professional lives appears necessary to improve teacher retention and consequently have a positive impact on a student’s school experience. This research examined the experiences of …

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Working Paper: Domestic Violence Prevention Education For Middle School And High School Students In The State Of California, Marina Sangit Jan 2020

Working Paper: Domestic Violence Prevention Education For Middle School And High School Students In The State Of California, Marina Sangit

Pepperdine Policy Review

California has been a leader in policy across the globe, but still lags behind in responding to research that shows children ages 11-17 are most vulnerable to domestic violence. While California has some of the strongest models of domestic violence prevention education for college campuses, it has failed to institute comparable systems in K-12 public education. States like Virginia and Ohio now surpass California in strong prevention policies, which outline standards for content and mandate timelines for implementation. California should implement a policy that mandates base-level orientation on domestic violence, sets a requirement for California’s health framework that includes a …

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The Affectivity Of Good Teaching: Towards The Transformative Practice Of Possessing A 'Thinking Heart', Glenn Morrison Jan 2020

The Affectivity Of Good Teaching: Towards The Transformative Practice Of Possessing A 'Thinking Heart', Glenn Morrison

Theology Papers and Journal Articles

The aim of the article is to develop a phenomenological and theological approach to the affectivity of good teaching to foster a transformative practice of student engagement and awareness of the life of the soul as much as the mind and the heart. Drawing on the Catholic Intellectual Tradition’s search for truth in the context of the theological virtues of faith, hope and love, the article sets out to articulate what it means to possess a thinking heart of education by way of engaging seven transcendental imperatives: be spontaneous, be imaginative, be hopeful, be faithful, be pastoral, be not afraid, …

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Influence Of Project-Based Learning And Homogeneous Grouping On Gifted Students' Cognitive Abilities, Pamela Stewart Holman Jan 2020

Influence Of Project-Based Learning And Homogeneous Grouping On Gifted Students' Cognitive Abilities, Pamela Stewart Holman

Walden Dissertations and Doctoral Studies

The problem investigated in this study was the lack of an appropriate educational setting for gifted and talented students (GATSs) in New Jersey. Accordingly, the purpose of this study was to determine the differences in cognitive abilities between GATSs who participated in project-based learning (PBL), and if so, in homogeneous grouping (HG) or not, and GATSs who did not participate in PBL. The theoretical frameworks used in this study were the theories of learning, creativity, and critical thinking of Vygotsky and Piaget. The research questions addressed differences in GATSs' cognitive abilities as measured by score changes in the scaled verbal, …

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Self-Efficacy And Burnout And Their Impact On School Counselors, Jacqueline Jacobs Jan 2020

Self-Efficacy And Burnout And Their Impact On School Counselors, Jacqueline Jacobs

Walden Dissertations and Doctoral Studies

Policymakers focused on school and mental health proposals in the wake of shooting in Newton, Connecticut. Since this incident a policy is being considered to restrict gun use and increase mental health and student support services. In 2012, the Department of Education explored five emerging issues that impact learning: (a) school discipline, (b) gender-based violence, (c) behavioral health, (d) bullying, and (e) school safety. These five issues, when they impact the learning environment, the school counselor may exhibit increased anxiety that may lead to burnout. Additionally, the school climate may be impacted by the relationship with administrators and staff. If …

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Understanding Stakeholder Interests In Rulemaking Through The Lens Of Private-Interest Institutionalism, Walter Lewis Koski Jan 2020

Understanding Stakeholder Interests In Rulemaking Through The Lens Of Private-Interest Institutionalism, Walter Lewis Koski

Walden Dissertations and Doctoral Studies

State regulators have the task of promulgating regulations for multiple heavily regulated industries, but there is a dearth of research to help public policy makers better understand how rulemaking processes are perceived by stakeholders in those processes. Regulators who promulgated rules for the legalization of marijuana in Colorado used both required and discretionary methods of participation in rulemaking to involve stakeholders with multiple competing interests. This qualitative research study was based on a phenomenological approach and interview data from 10 stakeholders who participated in the Colorado Marijuana Enforcement Division's rulemaking processes between 2013 and 2016. The purpose of this study …

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Exploring Destination Imagination Alumni Perceptions Of 21st-Century Skills And Workforce Readiness, Sharon Kovalevsky Jan 2020

Exploring Destination Imagination Alumni Perceptions Of 21st-Century Skills And Workforce Readiness, Sharon Kovalevsky

Walden Dissertations and Doctoral Studies

Workplace requirements are vastly different from the past due to rapid changes in technology and globalization, and they require graduates to have well-developed 21st-century skills and innovation strategies. The problem addressed in this study was the lack of understanding of how 21st-century skills that alumni learned through academic extracurricular experiences informed their early career and workforce readiness. The purpose of this qualitative study was to explore how Destination Imagination (DI) alumni perceived that the 21st-century skills they learned as part of their academic extracurricular experiences informed their early career readiness. The study was grounded by the 3 constructs of work …

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Strategies For Hiring People With Disabilities To Prevent A Skilled Worker Shortage, Andreas Kyprianou Jan 2020

Strategies For Hiring People With Disabilities To Prevent A Skilled Worker Shortage, Andreas Kyprianou

Walden Dissertations and Doctoral Studies

Many business sectors are currently facing challenges in the labor market and will need to address inefficiencies in their recruitment and retention strategies. Restaurant managers who lack strategies for recruiting nontraditional staff, such as people with disabilities, risk declining competitiveness because of this labor shortage. Grounded in stakeholder theory, the purpose of this multiple case study was to explore strategies restaurant managers use to recruit and hire people with disabilities to prevent or address skilled worker shortages. The participants comprised 7 quick service restaurant (QSR) franchisees and managers from the same QSR brand in Canada with previous experience recruiting staff …

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Perceptions Of Academic Success Of English As A Second Language Nursing Students, Jean Lansang Jan 2020

Perceptions Of Academic Success Of English As A Second Language Nursing Students, Jean Lansang

Walden Dissertations and Doctoral Studies

Hispanic or Latino and Asian communities represent two of the rapid-growing ethnicities who seek healthcare in the United States. However, the U.S. nursing workforce does not reflect the ethnic or cultural makeup of the patient population. The purpose of this study was to examine the lived experiences of Asian and Hispanic or Latino English as a second language (ESL) nursing students and learn the barriers and facilitators they experienced in their nursing program. A qualitative phenomenological approach underpinned by the social-ecological model and the Cummins language acquisition model was used for the study. Face-to-face interviews were conducted with 7 Asian …

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Influence Of Supervisor Support And Resilience On Productivity And Turnover Intentions In Pediatric Health Care, Adrienne Y. Martin Jan 2020

Influence Of Supervisor Support And Resilience On Productivity And Turnover Intentions In Pediatric Health Care, Adrienne Y. Martin

Walden Dissertations and Doctoral Studies

Workplace violence has become a critical safety issue in the health care setting, often leading to increased stress levels and employees that feel unsupported and inadequately prepared; which leads to increased turnover, and subsequently, diminished overall organizational productivity and poorer patient outcomes. The purpose of this study was to examine whether supervisor support and resilience affect productivity and turnover intent related to professional role and work experience following workplace violence in the pediatric health care setting. Organizational support theory and the framework of the resilience model provided the theoretical structure for this study. Data were collected through anonymous surveys with …

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Introducing Exercise And Home Safety Check To Decrease Falls In Older Adults, Alie Theresa Massicot-Gray Jan 2020

Introducing Exercise And Home Safety Check To Decrease Falls In Older Adults, Alie Theresa Massicot-Gray

Walden Dissertations and Doctoral Studies

The lack of education related to causes of, complications from, and interventions for falls is associated with the high rate of falls and fall-related injuries in older adults (OAs) beginning at age 65. The purpose of this project was to develop a fall prevention program that included components of the Stopping Elderly Accidents Deaths & Injuries Algorithm to increase fall prevention awareness and reduce falls in OAs at one community senior center. The project practice question asked whether introducing a fall prevention program that focused on exercise and home safety checks to educate OAs could decrease the rate of falls. …

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Relationship Between Transformational Leadership, Employee Satisfaction And Job Performance Of Virtual Workers, Alice Miller Jan 2020

Relationship Between Transformational Leadership, Employee Satisfaction And Job Performance Of Virtual Workers, Alice Miller

Walden Dissertations and Doctoral Studies

The effects of leaders on virtual employees job satisfaction and job performance is essential to virtual team success. As virtual workplaces continue to evolve, there is a need to focus research on how leaders affect virtual employees. Previous research has indicated that understanding the relationship between perceived leadership and job satisfaction is crucial as it helps create a motivated and effective workforce. However there remains an essential gap in current literature regarding leadership effectiveness on job satisfaction and job performance of virtual workers. The population group for this study consisted of 70 randomly selected virtual employees. Participants of the study …

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Measuring Knowledge Of Chronic Kidney Disease (Ckd) Among Community College Students, Jacquelyn Caldwell Moore Jan 2020

Measuring Knowledge Of Chronic Kidney Disease (Ckd) Among Community College Students, Jacquelyn Caldwell Moore

Walden Dissertations and Doctoral Studies

Chronic Kidney Disease (CKD) once detected is easily treated; however, it has become a major health problem associated with increased morbidity and mortality rates, creating an economic burden worldwide. While approximately 24 million Americans over the age of 20 suffer from CKD, there is a lack of awareness among the general population. Using a pre/post assessment, this quantitative study measured the impact of a 75-minute workshop on 126 community college students' knowledge of kidney disease, perception of its severity, and perceived susceptibility. The theoretical framework for the study was the health belief model, which suggests that individuals will make positive …

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Teacher Perceptions Of Leadership Styles And The Relationship To Job Satisfaction In Adult Basic Education Settings, Troy James Nickel Jan 2020

Teacher Perceptions Of Leadership Styles And The Relationship To Job Satisfaction In Adult Basic Education Settings, Troy James Nickel

Walden Dissertations and Doctoral Studies

Adult basic education (ABE) teacher job satisfaction presents as a need for research to examine how the policy shifts to meet accountability requirements have influenced leadership styles in ABE settings. The study aimed to investigate the impact of leadership style (transformational, transactional, and laissez-faire) on job satisfaction of ABE teachers. Additionally, specific ABE teacher demographic variables that influenced the relationship between leadership style on teacher job satisfaction were examined. The theoretical framework applied to the study was the Transformational Leadership Theory. The Multifactor Leadership Questionnaire (MLQ) and Job Satisfaction Survey (JSS) were administered to 137 ABE teachers from across the …

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Social Responsibility Perceptions Of Community Flood Resilience In Nigeria, Reginald Olisa Oranye Jan 2020

Social Responsibility Perceptions Of Community Flood Resilience In Nigeria, Reginald Olisa Oranye

Walden Dissertations and Doctoral Studies

Flooding is a severe threat to livelihoods and socioeconomic development in Ogbaru riverine communities of Anambra State, Nigeria. Limited success in the traditional approach of using predominantly structural measures, such as flood channels, to manage floods makes it imperative to explore nonstructural resilience initiatives that would potentially better protect vulnerable flood-prone communities. This study contributes to addressing the problems of ineffective flood management by developing vital social responsibility (SR) data and information that can enhance community flood resilience through individual and collective responsibilities for resilient action. The purpose of this quantitative correlational study was to explore SR perceptions of flood …

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Exploring The Impacts Of Workplace Loneliness On Criminal Justice Senior Leaders, Johanna Papa Jan 2020

Exploring The Impacts Of Workplace Loneliness On Criminal Justice Senior Leaders, Johanna Papa

Walden Dissertations and Doctoral Studies

This phenomenological qualitative study aimed to explore the impacts of workplace loneliness on senior leaders of various criminal justice organizations. The theoretical framework used was Descartes' views of the self-concept theory, which explained how individuals defined and described themselves within a social context. Using purposive sampling and semistructured telephone, and email interviews of 16 criminal justice senior leaders from the Washington, D.C. metropolitan area, this research was conducted to answer the overarching question of this study. Workplace loneliness was a professional hazard. The key findings revealed that at least 87% of the criminal justice senior leaders reported feeling or have …

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