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2020

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Vehicle-Based Structural Health Monitoring Of Bridges, Zhenhua Shi Jan 2020

Vehicle-Based Structural Health Monitoring Of Bridges, Zhenhua Shi

All ETDs from UAB

Structural health monitoring of bridges serves a critical role in maintaining a safe transportation network. Compared to the traditional resource-consuming direct approaches which usually require labor-intensive inspection and deployment of multiple sensors directly on the bridge, the indirect approach has been gained more and more attention due to its mobility and potential economy characteristics. The indirect approach utilizes the dynamic responses from the vehicle that interacts with the bridge so that the health status of the monitored bridges can be timely and effectively reflected via their structural dynamic characteristics such as frequencies, mode shapes, and damping properties. This research explores …

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Mitochondrial Priming Of Tumor Initiating Cells Involves Repression Of Mitochondrial Fission Activity Towards Redox Regulation Of The Cell Cycle Regulator Cyclin E, Brian Spurlock Jan 2020

Mitochondrial Priming Of Tumor Initiating Cells Involves Repression Of Mitochondrial Fission Activity Towards Redox Regulation Of The Cell Cycle Regulator Cyclin E, Brian Spurlock

All ETDs from UAB

Mitochondrial dynamics primarily refers to the opposing fission or fusion events between individual mitochondria, which maintains steady-state mitochondrial morphology in cells. Fission and fusion activities maintain the energetics of normal and neoplastic stem cells. We developed the novel approach mito-SinCe2 to study the bidirectional relationship between mitochondrial dynamics and energetics. Application of this method led to the hypothesis that mitochondria-dependent ovarian tumor initiating cells interconvert between 3 states with distinct mitochondrial energetics/dynamics relationships. Cells in one state, characterized by high mitochondrial ROS and low fission activity, appear to be primed for self-renewal by mitochondria. We call these cells mitochondria-primed stem …

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A Case Study Of The Beliefs And Perspectives Of Professional Development Consultants While Conducting College, Career, And Community Writers Program, Jameka Thomas Jan 2020

A Case Study Of The Beliefs And Perspectives Of Professional Development Consultants While Conducting College, Career, And Community Writers Program, Jameka Thomas

All ETDs from UAB

This qualitative multi-case study examined 12 professional development consultants’ (PDC) beliefs and perspectives while conducting College, Career, and Community Writers Program from two National Writing Project sites. Sage Mountain and Kinship. For this study, there were two theoretical frameworks examined, Peer Coaching (Showers & Joyce, 1996) and Skilled Facilitator Approach (Schwarz, 2005). Other theories that helped ground the framework of this study were Cognitive Coaching (Costa & Garmston, 1994), Zen of Facilitation (Killion & Simmons, 1992), and Typologies of Facilitator Education (Thomas, 2004). Through an integration of the five perspectives, the researcher found that PDCs in both sites shared common …

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Exploring The Development Of Logico-Mathematical Knowledge In 5- 6-Year-Olds In Kuwait, Mohammad Alazemi Jan 2020

Exploring The Development Of Logico-Mathematical Knowledge In 5- 6-Year-Olds In Kuwait, Mohammad Alazemi

All ETDs from UAB

The purpose of the qualitative case study was to explore the development of logico-mathematical knowledge in twenty 5- and 6-year-old children in Kuwait. The researcher conducted the study in a real-life bounded system over approximately two-months. The researcher utilized constant comparison analysis to interpret the responses of children during clinical interviews to explore hierarchical classification and seriation as two types of logico-mathematical knowledge. The researcher also observed children and used constant comparison analysis to interpret the behaviors of children throughout physical knowledge activities to explore the nature of each child’s thinking. The central research questions were: 1) What types of …

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Calibration Of Periodontal Diagnosis Among Participants Of Various Dental Education Levels, Shadi Alkhoury Jan 2020

Calibration Of Periodontal Diagnosis Among Participants Of Various Dental Education Levels, Shadi Alkhoury

All ETDs from UAB

ABSTRACT: The purpose of this project is to assess the level of calibration among dental students of two different education levels and postgraduate students of two different dental specialties during diagnosis and treatment planning of clinical cases with various levels of periodontal involvement, using the 2018 Classification of Periodontal and Peri-implant Diseases and Conditions. Fifty-seven second year dental students (D2), 45 fourth year dental students (D4), 17 orthodontic postgraduate students (OS) and 12 postgraduate periodontology (PS) students were presented with an anonymous survey of 10 different cases, each with 5 choices of diagnosis and 7 therapeutic approaches. Consensus diagnosis was …

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Creatinine Detection Based On Molecularly Imprinted Technique And Luminescence Of Nano-Diamond As A Signal Transducer, Reim Almotiri Jan 2020

Creatinine Detection Based On Molecularly Imprinted Technique And Luminescence Of Nano-Diamond As A Signal Transducer, Reim Almotiri

All ETDs from UAB

Creatinine measurement is an important diagnostic test for assessing kidney health. This work represents our current progress in creatinine artificial sensor based on a molecularly imprinted polymer of polyacrylamide hydrogel and nanodiamonds fluorescence change. For a 0.3 mM creatinine rebinding solution, an imprinting factor of 2.54 was measured. Also, a molecularly imprinted polymer was obtained by incorporating nanodiamond into a creatinine-imprinted polyacrylamide hydrogel. The quenching of peak nanodiamond fluorescence was significantly higher in the creatinine-imprinted polymer compared to the non-imprinted polymer, indicative of higher creatinine affinity in the imprinted polymer. Nanodiamond fluorescence from nitrogen-vacancy color centers (NV- and NV0) was …

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Mid-Fusiform Sulcus Anatomy And Its Relationship To Face Processing And Social Functioning In Autism Spectrum Disorder, Carla Ammons Jan 2020

Mid-Fusiform Sulcus Anatomy And Its Relationship To Face Processing And Social Functioning In Autism Spectrum Disorder, Carla Ammons

All ETDs from UAB

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and restricted and repetitive behaviors and interests. One of the most consistent findings in ASD is reduced attention to and atypical processing of faces. However, the brain basis of aberrant face processing in ASD remains opaque. A novel neuroanatomical feature, the mid-fusiform sulcus (MFS), is strongly associated with face-selective regions of the fusiform gyrus (FG) as well as other large-scale functional and structural divisions in the ventral temporal cortex (Weiner et al., 2014). However, this feature is unexplored in ASD. The overarching goal of this dissertation …

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Cyp1a2 Genotype And Acute Effects Of Caffeine On Resistance Exercise, Jumping, And Sprinting Performance, Jozo Grgic, Craig Pickering, David J. Bishop, Brad J. Schoenfeld, Pavle Mikulic, Zeljko Pedisic Jan 2020

Cyp1a2 Genotype And Acute Effects Of Caffeine On Resistance Exercise, Jumping, And Sprinting Performance, Jozo Grgic, Craig Pickering, David J. Bishop, Brad J. Schoenfeld, Pavle Mikulic, Zeljko Pedisic

Research outputs 2014 to 2021

Background: It has been suggested that polymorphisms within CYP1A2 impact inter-individual variation in the response to caffeine. The purpose of this study was to explore the acute effects of caffeine on resistance exercise, jumping, and sprinting performance in a sample of resistance-trained men, and to examine the influence of genetic variation of CYP1A2 (rs762551) on the individual variation in responses to caffeine ingestion. Methods: Twenty-two men were included as participants (AA homozygotes n = 13; C-allele carriers n = 9) and were tested after the ingestion of caffeine (3 mg/kg of body mass) and a placebo. Exercise performance was assessed …

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Let The Data Speak: Using Rigour To Extract Vitality From Qualitative Data, Alistair J. Campbell Jan 2020

Let The Data Speak: Using Rigour To Extract Vitality From Qualitative Data, Alistair J. Campbell

Research outputs 2014 to 2021

Qualitative data can be gathered from an array of rich sources of research information. One of the popular ways to collect this data is by interviewing a range of experts on the topic, followed by transcription, resulting in a database of written documents, often supplemented by other documented data that informs the topic. Thematic or Content Analysis can then be used to explore the data and identify themes of meaning that enlighten the research topic, with the themes being gathered into nodes. The researcher now has an array of nodes, which needs to be organised into a coherent model, and …

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The Current Application Of The Myriad And Mayo/Alice Rulings On Patent Eligibility: Inconsistent Results And Contradistinguishing Biotechnology Products, Skye Cho Jan 2020

The Current Application Of The Myriad And Mayo/Alice Rulings On Patent Eligibility: Inconsistent Results And Contradistinguishing Biotechnology Products, Skye Cho

Cardozo Arts & Entertainment Law Journal

The note examines the inconsistent application of the patent eligibility framework under Section 101 of the Patent Act, particularly in biotechnology. It argues that despite efforts by the USPTO to clarify the framework through memos and examples, courts have applied it inconsistently, leading to discrimination against biotechnology products. The analysis focuses on key Supreme Court decisions, such as Myriad Genetics and Mayo, and their impact on the patent eligibility of biotechnological innovations. The note highlights the need for clearer guidance to ensure consistent outcomes and fair treatment of biotechnological inventions.

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Patent Fraud By Design, Mordechay Sorek, Miriam Marcowitz-Bitton, Yotam Kaplan Jan 2020

Patent Fraud By Design, Mordechay Sorek, Miriam Marcowitz-Bitton, Yotam Kaplan

Cardozo Arts & Entertainment Law Journal

Patent law is supposed to offer property-right protection to inventors in order to promote and incentivize innovation. Yet current patent law doctrine effectively incentivizes patentees to defraud the patent office, allowing them to secure undeserved legal protection. What is worse, once such protection is fraudulently obtained, patentees can use it to stop downstream innovation, harm competitors, and charge supracompetitive prices to consumers. The current patent system generates all of these harms because it offers strong legal protection while failing to impose equally strong sanctions against those who attempt to abuse it. Indeed, the current system rarely sanctions patentees who have …

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Tonal Concept And Feel, Joseph P. Fishman Jan 2020

Tonal Concept And Feel, Joseph P. Fishman

Cardozo Arts & Entertainment Law Journal

The article challenges the notion that the "total concept and feel" test is a primary driver of expanding copyright liability in music infringement cases. It argues that while this test is often criticized for its subjectivity, it is not the main culprit behind the perceived expansion of copyright protection. Instead, the complexity of expert analysis and the increasing number of musical elements considered in infringement claims—such as harmony, rhythm, and timbre—play a more significant role in shaping outcomes. The author contends that the test is less problematic than often portrayed and that efforts to reform copyright doctrine should focus on …

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Transforming “Total Concept And Feel”; Dialogic Creativity And Copyright’S Substantial Similarity Doctrine, Carys J. Craig Jan 2020

Transforming “Total Concept And Feel”; Dialogic Creativity And Copyright’S Substantial Similarity Doctrine, Carys J. Craig

Cardozo Arts & Entertainment Law Journal

Copyright infringement doctrine currently overprotects copyright owners against the perceived wrong of copying, failing to adequately countenance copying as an essential part of the authorial creative process. Drawing on existing infringement doctrine in the United States and Canada, this Article will offer an interpretation of "substantial similarity" that opens up (or at least better safeguards) space for creative copying that is to say, copying that substantially transforms the original copied work and, in doing so, advances the public interest goals of the copyright system. Part I lays the groundwork by briefly presenting a dialogic vision of authorship that complicates conventional …

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The Legal Recognition Of Electronic Bills Of Lading, Ali Abbas Khayoon Al-Naseri Jan 2020

The Legal Recognition Of Electronic Bills Of Lading, Ali Abbas Khayoon Al-Naseri

World Maritime University Ph.D. Dissertations

The increasing use of electronic devices, new means of communication and Internet affects many areas of life, including trade and transportation. One effect is the dematerialization of bills of lading. Paper bills of lading have traditionally performed three main functions in maritime transportation: (1) as a receipt for the goods, (2) as containing or evidencing the contract of carriage of goods and (3) as a document of title. This legal research examines whether electronic bills of lading can legally perform these three functions as functional equivalents to paper bills of lading. It studies the recognition of electronic bills of lading …

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Exploring The Efficacy Of The Expiratory Muscle Strength Trainer To Improve Swallowing In Inclusion Body Myositis: A Pilot Study, Nika Mohannak, Gemma Pattison, Bronwyn Radich, Kathryn Hird, Erin Godecke, Frank L. Mastaglia, Merrilee Needham Jan 2020

Exploring The Efficacy Of The Expiratory Muscle Strength Trainer To Improve Swallowing In Inclusion Body Myositis: A Pilot Study, Nika Mohannak, Gemma Pattison, Bronwyn Radich, Kathryn Hird, Erin Godecke, Frank L. Mastaglia, Merrilee Needham

Medical Papers and Journal Articles

Inclusion Body Myositis (IBM) is the most common acquired myopathy in older individuals with more than two thirds of patients experiencing impaired swallowing. There are currently no standardized exercise therapies to improve or sustain swallowing despite good evidence for exercise therapy in limb muscles. Reduced upper esophageal sphincter (UES) opening is a common abnormality associated with dysphagia in IBM. This pilot study recruited IBM patients with abnormal UES function and dysphagia into an exercise program. It was hypothesised that regular practice using the Expiratory Muscle Strength Trainer (EMST) device would improve hyolaryngeal movement by strengthening suprahyoid musculature and facilitate opening …

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Systemic Vasculitides. Part 1: Large, Medium And Variable Vessel Diseases, Sean M. Conte, Peter R. Vale Jan 2020

Systemic Vasculitides. Part 1: Large, Medium And Variable Vessel Diseases, Sean M. Conte, Peter R. Vale

Medical Papers and Journal Articles

Vasculitis, or inflammation of vessel walls, is common and consists of a diverse array of disease entities encompassing virtually all organ systems. As onset is typically subacute and nonspecific, affected patients usually first seek attention from primary care providers. Size and distribution of the affected vasculature dictate end-organ manifestations and preliminary screening tests. Complications may carry high morbidity and mortality; therefore, prompt recognition, specialist referral and institution of immunosuppressive therapy are crucial to obviate potentially poor outcomes.

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Systemic Vasculitides. Part 2: Small Vessel Diseases, Sean M. Conte, Peter R. Vale Jan 2020

Systemic Vasculitides. Part 2: Small Vessel Diseases, Sean M. Conte, Peter R. Vale

Medical Papers and Journal Articles

Small vessel vasculitides often manifest as neurological, renal, pulmonary and dermatological symptoms. Clinical features of systemic vasculitides are often nonspecific; therefore, it is important that GPs be aware of the range of symptoms that can help in the differential diagnosis, treatment and management of this diverse group of conditions.

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Equitable Expanded Carrier Screening Needs Indigenous Clinical And Population Genomic Data, Simon Easteal, Ruth M. Arkell, Renzo F. Balboa, Shayne A. Bellingham, Alex D. Brown, Tom Calma, Matthew C. Cook, Megan Davis, Hugh J.S Dawkins, Marcel E. Dinger, Michael S. Dobbie, Ashley Farlow, Kylie G. Gwynne, Azure Hermes, Wendy E. Hoy, Misty R. Jenkins, Simon H. Jiang, Warren Kaplan, Stephen Leslie, Bastien Llamas, Graham J. Mann, Brendan J. Mcmorran, Rebekah E. Mcwhirter, Cliff J. Meldrum, Shivashankar H. Nagaraj, Saul J. Newman, Jack S. Nunn, Lyndon Ormond-Parker, Neil J. Orr, Devashi Paliwal, Hardip R. Patel, Glenn Pearson, Greg R. Pratt, Boe Rambaldini, Lynette W. Russell, Ravi Savarirayan, Matthew Silcocks, John C. Skinner, Yassine Souilmi, Carola G. Vinuesa, Gareth Baynam Jan 2020

Equitable Expanded Carrier Screening Needs Indigenous Clinical And Population Genomic Data, Simon Easteal, Ruth M. Arkell, Renzo F. Balboa, Shayne A. Bellingham, Alex D. Brown, Tom Calma, Matthew C. Cook, Megan Davis, Hugh J.S Dawkins, Marcel E. Dinger, Michael S. Dobbie, Ashley Farlow, Kylie G. Gwynne, Azure Hermes, Wendy E. Hoy, Misty R. Jenkins, Simon H. Jiang, Warren Kaplan, Stephen Leslie, Bastien Llamas, Graham J. Mann, Brendan J. Mcmorran, Rebekah E. Mcwhirter, Cliff J. Meldrum, Shivashankar H. Nagaraj, Saul J. Newman, Jack S. Nunn, Lyndon Ormond-Parker, Neil J. Orr, Devashi Paliwal, Hardip R. Patel, Glenn Pearson, Greg R. Pratt, Boe Rambaldini, Lynette W. Russell, Ravi Savarirayan, Matthew Silcocks, John C. Skinner, Yassine Souilmi, Carola G. Vinuesa, Gareth Baynam

Medical Papers and Journal Articles

Expanded carrier screening (ECS) for recessive monogenic diseases requires prior knowledge of genomic variation including DNA variants that cause disease. The composition of pathogenic variants differs greatly among human populations, but historically research about monogenic diseases has focused mainly on people with European ancestry. By comparison, less is known about pathogenic DNA variants in people from other parts of the world. Consequently, inclusion of currently under-represented Indigenous and other minority population groups in genomic research is essential to enable equitable outcomes in ECS and other areas of genomic medicine. Here we discuss this issue in relation to the implementation of …

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The Non-Protostegid Cretaceous Marine Turtles Of Alabama And Their Bearing On The Evolution Of Extant Chelonioids, Andrew Gentry Jan 2020

The Non-Protostegid Cretaceous Marine Turtles Of Alabama And Their Bearing On The Evolution Of Extant Chelonioids, Andrew Gentry

All ETDs from UAB

The non-protostegid marine turtle fossils recovered from the Late Cretaceous of Alabama may represent some of the most recent common ancestors of modern marine turtles. Despite their evolutionary significance, almost no formal studies have been conducted on these animals for more than 60 years. Many of these species are known from incomplete holotypes which has led to decades of systematic ambiguity and made specific referrals of recently collected fossil material exceedingly challenging. The aim of this study is to review and describe the specimens of Cretaceous marine turtles collected from Alabama to determine if this material can be used to …

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Stimuli-Responsive Polymeric Particles: Ph-Sensitive Multilayer Capsules And Biodegradable Polylactic Acid Microsponges, Nirzari Gupta Jan 2020

Stimuli-Responsive Polymeric Particles: Ph-Sensitive Multilayer Capsules And Biodegradable Polylactic Acid Microsponges, Nirzari Gupta

All ETDs from UAB

The behavior of stimuli-responsive polymers is often inspired by the desire to mimic nature. Over the years, the development of polymeric systems, which respond to the environment by changing their physical and/or chemical properties, has been increased in biomedical and environmental applications. The demand for fresh water is also growing dramatically. This long-term development in the global water situation is closely connected to the growth of the world population and global climate change. In recent years, the use of nanomaterials in water remediation has increased considerably. In addition, shape and stimuli-responsiveness to size and surface chemistry of micro-engineered delivery carriers …

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Identifying Micro-Level Determinants That Influence The Transportation Network Companies (Tncs) Growth Through Analysis Of Transportation Users’ Preferences And Attitudes, Sahila Sarjana Jan 2020

Identifying Micro-Level Determinants That Influence The Transportation Network Companies (Tncs) Growth Through Analysis Of Transportation Users’ Preferences And Attitudes, Sahila Sarjana

All ETDs from UAB

In the recent years, the use of Transportation Network Companies (TNCs) such as Uber/Lyft as a mode of travel has been growing at a significant pace. Despite the rapid growth of several TNC markets, analyses of potential and actual impacts of TNCs presence on preferences and travel patterns of TNC-aware users are still very limited. Such analyses require detailed trip data which are not easily available due to privacy concerns, as well as technical and financial feasibility issues. To address some of these issues, the objective of this study was to document the factors that influence transportation users in the …

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Rna Polymerase I Elongation Kinetics: A Biochemical And Global Study Of A Cancer Therapeutic Target, Catherine Elizabeth Scull Jan 2020

Rna Polymerase I Elongation Kinetics: A Biochemical And Global Study Of A Cancer Therapeutic Target, Catherine Elizabeth Scull

All ETDs from UAB

My graduate research has focused on understanding the elongation kinetics of RNA polymerase I (Pol I), the enzyme responsible for synthesizing ribosomal RNA (rRNA), and defining how inhibition of ribosome biogenesis may be used as a cancer therapeutic strategy. Here, I have defined key biophysical features of Pol I and I have expanded the field’s understanding of Pol I elongation by: 1) characterizing the enzymatic properties of Pol I by mutational analysis of the polymerase itself, and by 2) elucidating the role of DNA sequence on Pol I arrest and nucleolytic cleavage activity. In recent years, Pol I has become …

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Assessing Contributing Factors Of Relationship Satisfaction In Polyamorous And Monogamous Relationships, Irene Kushnir Jan 2020

Assessing Contributing Factors Of Relationship Satisfaction In Polyamorous And Monogamous Relationships, Irene Kushnir

Walden Dissertations and Doctoral Studies

The purpose of this study was to analyze and compare factors contributing to relationship satisfaction in polyamorous and monogamous relationships, as measured by the Characteristics of Marriage Inventory (CHARISMA). A total of 372 participants over the age of 18 who identified as being involved in either a long-term monogamous or polyamorous relationship completed the CHARISMA questionnaire. Two multivariate analyses of variance revealed 10 out of 18 importance ratings, and 4 out of the 18 satisfactions ratings were statistically significant between relationship types. However, an analysis of variance suggested no overall difference in satisfaction between the two groups. Past research had …

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Investigation Of Drp1 Inhibition As Potential Therapy In Pesticide-Based Models Of Parkinson's Disease, Jennifer Rhea Pinnell Jan 2020

Investigation Of Drp1 Inhibition As Potential Therapy In Pesticide-Based Models Of Parkinson's Disease, Jennifer Rhea Pinnell

Other Faculty of Health Theses

In this study I explored the impact of Drp1 inhibition on pathology in two different pesticide-based models of Parkinson’s disease, and found that paraquat induced autophagy blockade in vitro, which was abrogated by inhibition of Drp1 function through siRNA knockdown or expression of the Drp1K38A dominant negative. Rotenone and paraquat are two pesticides implicated in the pathophysiology and progression of Parkinson’s disease, a hypokinetic neurodegenerative disorder which results in motor and cognitive changes in patients. Previous studies confirmed pesticide-induced loss of dopaminergic neurons in the substantia nigra pars compacta in animal models, however further research was necessary to explore the …

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Clinical Outcomes Post-Implantation Of Multifocal And Toric Intraocular Lenses, Elizabeth Martha Law Jan 2020

Clinical Outcomes Post-Implantation Of Multifocal And Toric Intraocular Lenses, Elizabeth Martha Law

Other Faculty of Health Theses

In order to increase spectacle independence following cataract surgery and intraocular lens (IOL) implantation; correction of spherical refractive error, astigmatic error and presbyopia should all be given careful consideration. There are many premium IOLs, including multifocal intraocular lenses (MIOLs) and toric intraocular lenses (TIOLs), available to surgeons. In order to select the appropriate IOL to meet a patient’s lifestyle and expectations, clinicians must fully understand the characteristics of MIOL and TIOL designs. To date, there remain unanswered questions pertaining to MIOLs and TIOLs and by rigorous comparison of such lenses, this thesis aims to address some of the gaps in …

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Development And Characterisation Of An Immunocompetent Three-Dimensional Oral Mucosal Infection Model, Samantha Gould Jan 2020

Development And Characterisation Of An Immunocompetent Three-Dimensional Oral Mucosal Infection Model, Samantha Gould

Other Faculty of Health Theses

Oral mucosal models are valuable tools for studying oral infection. Existing models have been implemented to study pathogen tissue invasion and resultant damage. These models fail to incorporate an innate immune component such as macrophages, essential for study of host response to infection. Macrophages exist within a regulatory to inflammatory polarisation spectrum, whereby the local microenvironment determines their activity, contributing to the overall behaviour of a tissue. Three-dimensional oral mucosal models were formed using primary (POK) or immortalized (HaCaT) keratinocytes seeded upon a human gingival fibroblast (HGF) embedded type-1 collagen matrix. Later, HaCaT based models (3DOMMs) were further developed to …

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A Concept Analysis Of Compassion In Healthcare Practice, Sarah Tobin Jan 2020

A Concept Analysis Of Compassion In Healthcare Practice, Sarah Tobin

Other Faculty of Health Theses

The subject of compassion is frequently discussed in healthcare literature but despite this, is potentially poorly understood and lacks consensus in definition. This study sought to clarify what exactly is meant by the term compassion in a healthcare context and how this is defined in both the literature and, crucially, by the behaviour and experience of healthcare staff and the experience of service users. In order to establish a definition of compassion the hybrid approach to concept analysis based on the method described by Schwartz-Barcott and Kim (2000) was adopted, this model combines comprehensive literature review with a fieldwork element …

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Intrinsic Control Strategies For Herpesvirus-Based Vaccine Vectors, Hujaz Ismail Abdulrazzaq Alqirbi Jan 2020

Intrinsic Control Strategies For Herpesvirus-Based Vaccine Vectors, Hujaz Ismail Abdulrazzaq Alqirbi

Other Faculty of Health Theses

Herpesvirus-based vectors have been used in vaccine strategies to target zoonotic diseases such as Ebola and human monkeypox, through eliciting a highly immunogenic response. We are investigating strategies to attenuate the virus and control its ability to replicate and persist, while maintaining its ability to elicit protective immune responses. In this project we have investigated three distinct and innovative means to provide intrinsic control of herpesvirus-based vectors. The first strategy is based on deletion of a gene essential for viral latency to modify persistence in vivo. Studies by Thirion et al have shown that the bovine herpesvirus 4 (BoHV-4) ORF73 …

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Hot Food Takeaways Around Schools: Can Fast Food Be Healthier?, Claire Louise Turbutt Jan 2020

Hot Food Takeaways Around Schools: Can Fast Food Be Healthier?, Claire Louise Turbutt

Other Faculty of Health Theses

Obesity is the greatest global health challenge facing this generation; over half of the adult population are overweight or obese. Calls for food environment interventions include recommendations for restriction or banning of new fast food retailers (FFRs). The Takeaway Toolkit was published by the Chartered Institute of Environmental Health and aimed to alter consumption of unhealthy takeaway food through reformulation and behavioural insights. A systematic review assessing evidence on FFRs in the environment around schools in the United Kingdom (UK) was completed and published. This revealed a research gap around food environment interventions. A study was designed to investigate “the …

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Understanding The Role Of Dmob4 In Postembryonic Neural Stem Cell Mitotic Reactivation, Eleanor Gonzaga Jan 2020

Understanding The Role Of Dmob4 In Postembryonic Neural Stem Cell Mitotic Reactivation, Eleanor Gonzaga

Other Faculty of Health Theses

Brain homeostasis supports cognition and neural plasticity, the brains’ ability to adapt to its environment throughout life. These processes rely on replenishment from stem cells in the brain, termed Neural Stem Cells (NSCs). In the adult brain, most NSCs exist in a quiescent state and must activate to generate new neural progeny. Understanding how NSCs balance quiescence and activation is crucial for the development of brain repair therapies. Drosophila NSCs, termed neuroblasts (NBs), are a model to study reactivation from quiescence. The Hippo and Insulin pathways were reported to promote NB quiescence and reactivation, respectively. However, the underlying mechanisms are …

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