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Association Of Myh9-Rs3752462 Polymorphisms With Chronic Kidney Disease Among Clinically Diagnosed Hypertensive Patients: A Case-Control Study In A Ghanaian Population, William K. Owiredu, Michael Appiah, Christian Obirikorang, Evans Asamoah Adu, Vincent Boima, Ernestine Kubi Amos-Abanyie, Priscilla Abena Akyaw, Eddie-Williams Owiredu, Emmanuel Acheampong

Research outputs 2014 to 2021

Background: Chronic kidney disease (CKD) is a significant comorbidity among hypertensive patients. Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) have been demonstrated to be significantly associated with CKD, among African- and European-derived populations. We investigated the spectrum of MYH9-associated CKD among Ghanaian hypertensive patients. Methods: The study constituted a total of 264 hypertensive patients. Hypertensive patients with glomerular filtration rate (eGFR) < 60 ml/min/1.73m (CKD-EPI formula) or clinically diagnosed were defined as case subjects ( = 132) while those with eGFR ≥60 ml/min/1.73m were classified as control subjects ( = 132). Demographic data were obtained with a questionnaire and anthropometric measurements were taken. Five (5) millilitres (ml) of venous blood was drawn from study subjects into gel and EDTA vacutainer tubes. Two (2) mL of EDTA anticoagulated blood was used for genomic DNA extraction while three (3) mL of blood was processed to obtain serum for biochemical measurements. Genotyping of MYH9 polymorphisms (rs3752462) was done employing Tetra primer Amplification Refractory Mutation System (T-ARMS) polymerase chain reaction (PCR). Spot urine samples were also collected for urinalysis. Hardy-Weinberg population was assessed. Logistic regression models were used to assess the associations between single nucleotide polymorphisms and CKD. Results: The cases and control participants differed in terms of age, sex, family history, and duration of CKD (-value < 0.001). The minor allele frequencies of rs3752462 SNP were 0.820 and 0.567 respectively among the control and case subjects. Patients with the heterozygote genotype of rs3752462 (CT) were more likely to develop CKD [aOR = 7.82 (3.81-16.04)] whereas those with homozygote recessive variant (TT) were protective [aOR = 0.12 (0.06-0.25)]. Single nucleotide polymorphism of rs3752462 (CT genotype) was associated with increased proteinuria, albuminuria, and reduced eGFR. Conclusions: We have demonstrated that MYH9 polymorphisms exist among Ghanaian hypertensive patients and rs3752462 polymorphism of MYH9 is associated with CKD. This baseline indicates that further longitudinal and multi-institutional studies in larger cohorts in Ghana are warranted to evaluate MYH9 SNP as an independent predictor of CKD among hypertensive patients in Ghana.

Mechanisms Underpinning An Improvement In Dynamic Muscle Force Production Following A High-Intensity Warm-Up, Cody J. Wilson

Theses: Doctorates and Masters

The present research explored the mechanisms underpinning the enhancement of voluntary knee extensor torque after (1) extensive task-specific practice, and then (2) brief, intense warm-up exercise (conditioning activity; CA) as part of a complete warm-up routine. The same warm-up was completed in two Experiments (detailed below). In Experiment 1, voluntary (180⁰·s-1; T180) and electrically-evoked (isometric) knee extensor torques and electromyogram (EMG) and muscle temperature (Tm) data were recorded before and after (1) extensive task-specific practice where peak voluntary knee extensor performance was achieved, and (2) two isokinetic CAs matched for total concentric contraction time (CA60: 5 repetitions at 60⁰·s-1 vs. …

Cross-Border Regulation Of Securities Markets In Asean, Wai Yee Wan

Research Collection Yong Pung How School Of Law

How does cross-border regulation of securities markets work in Association of South East Asian Nations (ASEAN)? How closely are the securities markets coordinated within ASEAN from the regulatory perspective? What is the optimal regulatory model of integration of securities markets that balances the economic benefits of integration and yet minimizes the risks of contagion and advances the state’s national goals? The issues posed by these questions are important against the background of strong growth of the Asian economies and Asian capital markets, and how the ASEAN states can take advantage of such growth to facilitate economic growth. According to the …

Land Of The Falling "Poison Pill" Understanding Defensive Measures In Japan On Their Own Terms, Alan K. Koh, Masafumi Nakahigashi, Dan W. Puchniak

Research Collection Yong Pung How School Of Law

Embraced by United States ("U.S.") managers in the 1980s as a lifeline in a sea of hostile takeovers, the poison pill fundamentally altered the trajectory of American corporate governance. When a hostile takeover wave seemed imminent in Japan in the mid-2000s, Japanese boards appeared to embrace this American invention with equal enthusiasm. Japan's experience should have been a ringing endorsement for the utility of American corporate governance solutions in foreign jurisdictions -but it was not to be. Japan's unique interpretation of the "poison pill" that was so eagerly adopted by Japanese companies in the mid-to-late 2000s has turned out to …

Gait Entrainment In Coupled Oscillator Systems: Clarifying The Role Of Energy Optimization In Human Walking, Ryan T. Schroeder

Theses: Doctorates and Masters

Empirical evidence suggests that parameters of human gait (e.g. step frequency, step length) tend to minimize energy expenditure. However, it is unclear if individuals can adapt to dynamic environments in real time, i.e. continuously optimize energy expenditure, and to what extent. Two coupled oscillator systems were used to test the learned interactions of individuals within dynamic environments: (1) experienced farmworkers carrying oscillating loads on a flexible bamboo pole and (2) individuals walking on a treadmill while strapped to a mechatronics oscillator system providing periodic forces to the body. Reductionist trajectory optimization models predicted energy-minimizing gait interactions within the coupled oscillator …

The Jekyll’S Hide Project. Devising Jekyll’S Hide: A Critical Analysis Of The Performative Elements And Working Methods Of Jerry Lewis And The Butoh Dancers Tatsumi Hijikata And Kazuo Ohno, Hugo Belviso

Theses: Doctorates and Masters

This practice-led research project explored the process of devising for performance for the stage via physical theatre workshops. The research was informed by Japanese butoh dance-theatre and its two creators, Tatsumi Hijikata and Kazuo Ohno, and by the work of American comic Jerry Lewis. I began with exercises in group workshops derived from butoh movement practice, followed by inspiration drawn from Jerry Lewis’s performance and directorial work in his films, and from Robert Louis Stevenson’s Strange case of Dr Jekyll and Mr Hyde. I developed a workshop exercise and devising process where ideas and methodologies from butoh and Jerry …

Web Content Management System And Accessibility Awareness: A Comparative Study Of Novice Users And Accessibility Outcomes, Fatima Artiba Diaz

Theses: Doctorates and Masters

Since its creation, the Web has progressively developed and become a vital source of information in every domain and for almost all people. It is crucial to guarantee that the information contained on the Web is available for everyone, especially for people with special needs. Removing accessibility barriers is fundamentally based on tools, skills and support of all contributors, particularly the content creators, to ensure information is navigable and usable in the context of the end users experience. Web Content Management Systems play a significant role in structuring, storing and provision content to the Web and have evolved to address …

The Socialisation Of Early Career Principals In Western Australia, Simon Fittock

Theses: Doctorates and Masters

This research aimed to investigate and understand the socialisation of early career principals in Western Australian public schools. It is widely acknowledged that school principals are critical in the successful education of students and delivering on this is seen to be the core purpose of the role. It is evident that the development of effective principals has great value. As a result, the socialisation of principals during the formative early career stage, whereby they learn the necessary knowledge, skills and understandings of the role, is important in the educational experiences of students. Due to the impact principals have on student …

Rdtids: Rules And Decision Tree-Based Intrusion Detection System For Internet-Of-Things Networks, Mohammad Amine Ferrag, Leandros Maglaras, Ahmed Ahmim, Makhlouf Derdour, Helge Janicke

Research outputs 2014 to 2021

This paper proposes a novel intrusion detection system (IDS), named RDTIDS, for Internet-of-Things (IoT) networks. The RDTIDS combines different classifier approaches which are based on decision tree and rules-based concepts, namely, REP Tree, JRip algorithm and Forest PA. Specifically, the first and second method take as inputs features of the data set, and classify the network traffic as Attack/Benign. The third classifier uses features of the initial data set in addition to the outputs of the first and the second classifier as inputs. The experimental results obtained by analyzing the proposed IDS using the CICIDS2017 dataset and BoT-IoT dataset, attest …

Managing Science Teachers’ Adoption Of The 2005 Tanzanian Inquiry And Student-Centred Curriculum: Revealing Schoolbased Leaders’ Practices And Achievements, Noel Mark Makwinya

Theses: Doctorates and Masters

Many countries have made considerable changes to their education systems in response to the forces of globalisation. Tanzania is no exception. The most recent educational change attempt in Tanzania relates to the introduction of the 2005 Tanzanian Inquiry and Student- Centred Curriculum.

Sound change-leadership is a necessary condition for the realisation of change, particularly in influencing its adoption. Within the descriptive qualitative research paradigm, this study employed a Type IV (embedded and multiple) case-study design to examine and describe science teachers’ lived experiences in dealing with this latest Tanzanian curriculum and the role played by school-based leaders in influencing such …

Platelet Rich Fibrin As A Gingival Tissue Regeneration Enhancer, Ioana Codruta Mirica, Bianca Petrescu, Richard Miron, Radu Campian, Ondine Lucaciu

Journal of Dental Sciences

Abstract Tissue regenerative procedures aim to enhance regeneration of altered tissue. Extensive research has been carried out in this area and all proposed procedures present limitations. In this context the area of platelet-rich fibrin (PRF) research has gained tremendous awareness in the latest years. PRF is a low-cost regenerative modality that facilitates soft tissue regeneration derived from 100% autologous sources. It forms a fibrin mesh that liberates growth factors in a slow and prolonged manner and also contains supra-physiological concentrations of leukocytes. Reports from the literature have suggested that these leukocyte-rich blood-preparations are capable of improving wound healing, diminishing post-operative …

Guidance For Dental Treatment Of Patients With Disabilities During Covid-19 Pandemic, Kee-Yeon Kum, Eun-Jung Kwak, Jieun Kim, Hiran Perinpanayagam

Journal of Dental Sciences

Abstract People with disabilities are challenged managing their oral hygiene and more often burdened with oral diseases. They often require immediate dental treatment for severe pain and greater precautions are needed to cope with COVID-19. The potential for COVID-19 infection can be relatively high in patients with disabilities due to concomitant systemic diseases, unique individual circumstances, relationship with caregivers and the living conditions of long-term care facilities, which make them vulnerable to the virus. For behavior management, dental treatment is often provided under general anesthesia with meticulous preoperative evaluation and the use of high-quality viral filters. In response to COVID-19, …

No Happy Accident: Defining The Factors Contributing To The Success And Longevity Of A Long-Running Community Engagement Program, Jennifer Irvine

Theses: Doctorates and Masters

The Kalamunda Community Learning Centre (‘the Centre’) was established in 1977 by a group of four women, following their attendance at a conference held by the Women’s Electoral Lobby. Originally named the Kalamunda Women’s Learning Centre, it was established with a charter to improve the status of women, whilst providing a place to alleviate isolation and boredom for ‘stay at home’ mothers. Through its structure, underpinned by feminist ideology, the Centre also provided a place for women to practice skills that would build their confidence with respect to returning to the workforce. From its beginnings with a predominant focus on …

Implant-Supported Provisional Prosthesis Facilitated The Minor Revision Of Occlusion And Incisor Exposure After Orthognathic Surgery Of Extended Oligodontia In Maxilla, Jian Cao, Wenjie Zhou, Shunyao Shen, Yiqun Wu, Xudong Wang

Journal of Dental Sciences

Abstract Background The congenital oligodontia in maxilla could result in a significant skeletal jaw malformation such as atrophic maxilla and severe skeletal class III malocclusion. Since there is no referable dentition in anterior maxilla, the orthognathic surgery and oral rehabilitation for those patients becomes more challenging and less predictable. Materials and methods We hereby present a new sequencing of interdisciplinary treatments, including calvarial bone grafting, installation of implant-supported provisional prosthesis, bimaxillary orthognathic surgery, and the final installation of dental implants and the fixed prosthesis. Results The facial esthetics and function of the permanent prosthesis were satisfactory, with a remarkable improvement …

Changes In Student Attitudes And Beliefs After Sbirt Training, Jennifer Todd

All-Inclusive List of Electronic Theses and Dissertations

Substance use and abuse is a widespread issue and has resulted in the need for professionals to research and develop prevention efforts and interventions from a community based, public health approach. Those who are providing addictions related training in these settings often have limited time and resources with which to provide efficient and effective training. Information related to the impact of training with specific disciplines, such as social work, nursing, and physician assistant, is also needed in order to more effectively alter the approach based on those receiving the training. The purpose of this study was to evaluate factors that …

The Chironian 2020, New York Medical College

The Chironian

No abstract provided.

Mobile Ka-Band Polarimetric Doppler Radar Observations Of Wildfire Smoke Plumes, Taylor Brianna Aydell

Master's Theses

Remote sensing techniques have been more recently used to study and track wildfire smoke plume structure and evolution; however, knowledge gaps remain due to the limited availability of observational datasets aimed at understanding the fine-scale fire-atmosphere interactions and plume microphysics. In this study, we present a new mobile millimeter-wave (Ka-band) Doppler radar system acquired to sample the fine-scale kinematics and microphysical properties of active wildfire smoke plumes from both wildfires and large prescribed fires. Four field deployments were conducted in the fall of 2019 during two wildfires in California and one prescribed burn in Utah. An additional dataset of precipitation …

Racial Purges, Robert L. Tsai

Faculty Scholarship

In a two-year period, 1885-86, over 168 communities in America forcibly expelled Chinese residents from their midst. This essay, inspired by historian Beth Lew-Williams's book, THE CHINESE MUST GO, investigates the nineteenth-century purges of Chinese residents that occurred throughout the American west. I make three arguments. First, these acts of racial and political terror complicate our understanding of racial violence in America. Many of the actions were denounced, but they were also surprisingly effective in forcing business and political leaders to support the indefinite suspension of Chinese migration. Perpetrators faced almost no legal repercussions, and unlike for freed persons, racial …

The Growth And Need For Veterans Treatment Courts, Chad Lennon

Touro Law Review

No abstract provided.

Mobile Health Technologies May Be Acceptable Tools For Providing Social Support To Tuberculosis Patients In Rural Uganda: A Parallel Mixed-Method Study, Angella Musiimenta, Wilson Tumuhimbise, Esther Atukunda, Aaron T. Mugaba, Conrad Muzoora, Mari Armstrong-Hough, David Bangsberg, Multiple Additional Authors

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background. Social support has been shown to mitigate social barriers to medication adherence and improve tuberculosis (TB) treatment success rates. The use of mobile technology to activate social support systems among TB patients, however, has not been well explored. Moreover, studies that tie supportive SMS (Short Message Service) texts to electronic monitoring of TB medication adherence are lacking.

Objective. To explore TB patients’ current access to social support and perceptions of utilizing real-time adherence monitoring interventions to support medication adherence. Methods. We purposively selected TB patients who owned phones, had been taking TB medications for ≥1 month, were receiving their …

A Sexual Health Promotion App For Transgender Women (Trans Women Connected): Development And Usability Study, Christina J. Sun, Kirsten M. Anderson, Tamara Kuhn, Liat Tzvia Mayer, Charles H. Klein

OHSU-PSU School of Public Health Faculty Publications and Presentations

Background: HIV severely impacts the transgender communities in the United States, and transgender women have the highest HIV incidence rates among any identified risk group. Guided by formative research with transgender women and by an expert advisory panel of transgender women, we designed a prototype mobile app to promote HIV prevention among transgender women.

Objective: This study aimed to develop and test the usability and acceptability of the prototype Trans Women Connected mobile app.

Methods: We engaged in a 3-phase prototype development process. After conducting formative research about the health needs of this population, we outlined a theory-based app framework …

Validation Of Microrna Biomarkers For Alzheimer’S Disease In Human Cerebrospinal Fluid, Jack T. Wiedrick, Jay I. Phillips, Theresa A. Lusardi, Trevor J. Mcfarland, Babbet Lind, Ursula K. Sandau, Christina A. Harrington, Jodi A. Lapidusa, Multiple Additional Authors

OHSU-PSU School of Public Health Faculty Publications and Presentations

We previously discovered microRNAs (miRNAs) in cerebrospinal fluid (CSF) that differentiate Alzheimer’s disease (AD) patients from Controls. Here we examined the performance of 37 candidate AD miRNA biomarkers in a new and independent cohort of CSF from 47 AD patients and 71 Controls on custom TaqMan arrays. We employed a consensus ranking approach to provide an overall priority score for each miRNA, then used multimarker models to assess the relative contributions of the top-ranking miRNAs to differentiate AD from Controls. We assessed classification performance of the top-ranking miRNAs when combined with apolipoprotein E4 (APOE4) genotype status or CSF amyloid-β42 (Aβ42):total …

Association Of A Multisite Interprofessional Education Initiative With Quality Of Primary Care, Samuel T. Edwards, Elizabeth Hooker, Rebecca Brienza, Bridget O’Brien, Hyunjee Kim, Stuart Gilman, Nancy Harada, Lillian Gelberg, Sarah Shull, Meike Niederhausen, Multiple Additional Authors

OHSU-PSU School of Public Health Faculty Publications and Presentations

Importance Studies have shown that interprofessional education (IPE) improves learner proficiencies, but few have measured the association of IPE with patient outcomes, such as clinical quality.

Objective To estimate the association of a multisite IPE initiative with quality of care.

Design, Setting, and Participants This study used difference-in-differences analysis of US Department of Veterans Affairs (VA) electronic health record data from July 1, 2008, to June 30, 2015. Patients cared for by resident clinicians in 5 VA academic primary care clinics that participated in the Centers of Excellence in Primary Care Education (CoEPCE), an initiative designed to promote IPE among …

Annual Wellness Visits And Influenza Vaccinations Among Older Adults In The Us, Terese Sara Hoj Jørgensen, Heather G. Allore, Miriam R. Elman, Corey L. Nagel, Mengran Zhang, Sheila Markwardt, Ana R. Quiñones

OHSU-PSU School of Public Health Faculty Publications and Presentations

Objectives

Investigate whether combinations of sociodemographic factors, chronic conditions, and other health indicators pose barriers for older adults to access Annual Wellness Visits (AWVs) and influenza vaccinations.

Methods

Data on 4999 individuals aged ≥65 years from the 2012 wave of the Health and Retirement Study linked with Medicare claims were analyzed. Conditional Inference Tree (CIT) and Random Forest (CIRF) analyses identified the most important predictors of AWVs and influenza vaccinations. Multivariable logistic regression (MLR) was used to quantify the associations.

Results

Two-year uptake was 22.8% for AWVs and 65.9% for influenza vaccinations. For AWVs, geographical region and wealth emerged as …

Narrative Therapy To Reduce Self-Stigma: Empowering Children, Adolescents, And Their Families, Jillian Baldwin

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

The effects of self-stigma on children and adolescents with mental health diagnoses is a documented psychological issue in academic literature; however, no studies or articles to date present strategies for reducing its negative effects. Additionally, very few studies have connected the experience of parental stigma, or courtesy/affiliate stigma, and its effects on child and family well-being. Self-stigma has been conceptualized as existing on the opposite end of the spectrum from empowerment, suggesting that empowerment may serve as a promising approach to tackling self-stigmatization. This paper presents a novel therapeutic intervention for reducing self-stigma in children, adolescents, and their families through …

The Role Of Awareness In Traumatic Brain Injuries: Interviews With Experts, Dominique Chao

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Approximately 2.8 million US citizens sustain a traumatic brain injury (TBI) annually, with more than 275,000 requiring inpatient rehabilitation (Taylor, Bell & Breiding, 2013). As rehabilitation techniques are refined and adapted to increase the speed of recovery and functional independence following TBIs, there is an ongoing need for better prognostic assessment tools. Research has shown that a lack of self-awareness following TBI is associated with poorer outcomes (e.g. employability, community reintegration) following discharge from inpatient hospitalizations (Cheng & Man, 2006; Robertson & Schmitter, 2016) and can result in decreased motivation (Simmonds & Fleming, 2003), compromised safety, poor community re-integration, and …

Covid-19 And Individuals With Developmental Disabilities: Tragic Realities And Cautious Hope, Samuel J. Levine

Scholarly Works

The COVID-19 pandemic has cast the United States, along with the rest of the world, into a time of crisis and uncertainty unlike any other in recent memory. Months into the pandemic, there is scant agreement among scientists, government officials, and large segments of the public, both domestic and abroad, as to determining the causes and workings of the virus, designing appropriate and effective responses to the outbreak, and constructing accurate assessments of the future—or even of the present. Indeed, the availability of concrete information about the virus and its effects is grossly inadequate and often replaced by anecdotal or …

Access Law Schools & Diversifying The Profession, Deseriee A. Kennedy

Scholarly Works

Lawyers do not reflect the racial diversity in the United States. The legal profession continues to struggle with ways to achieve and maintain racial diversity. Law schools play a critical role in the path to practice, and therefore an examination of the barriers to the profession they created is warranted. This essay critiques the over-reliance on standardized testing in law school admissions and advocates for an open admissions process that prioritizes racial and academic diversity. It suggests that the benefits of minimizing the role of standardized tests far outweigh any perceived costs in legal education. This essay concludes that the …

A New Flexible Bathtub-Shaped Modification Of The Weibull Model: Properties And Applications, Qinghu Liao, Zubair Ahmad, Eisa Mahmoudi, Gholamhossein Hamedani

Mathematical and Statistical Science Faculty Research and Publications

Many studies have suggested the modifications and generalizations of the Weibull distribution to model the nonmonotone hazards. In this paper, we combine the logarithms of two cumulative hazard rate functions and propose a new modified form of the Weibull distribution. The newly proposed distribution may be called a new flexible extended Weibull distribution. Corresponding hazard rate function of the proposed distribution shows flexible (monotone and nonmonotone) shapes. Three different characterizations along with some mathematical properties are provided. We also consider the maximum likelihood estimation procedure to estimate the model parameters. For the illustrative purposes, two real applications from reliability engineering …

Should I Stay Or Should I Go: Student Housing, Remote Instruction, Campus Policies And Covid-19, Patricia E. Salkin, Pamela Ko

Scholarly Works

In March 2020, as the world scrambled to understand and address myriad public health and economic challenges unfolding from the novel coronavirus labeled COVID-19, higher education was forced into a tailspin. This article examines the legal and policy challenges that result from, among other issues, the congregate housing situations existing for on- and off-campus housing at colleges and universities. The legal issues demonstrate federalism at work and include; at the federal level, regulations and guidance from the White House, the Center for Disease Control (CDC) and the U.S. Department of Education; at the State level from gubernatorial executive orders, state …