Digital Commons Network^™

Adult Hippocampal Neurogenesis As A Potential Therapeutic Target In Fetal Alcohol Spectrum Disorders, Kymberly Cheyanne Gustus

Biomedical Sciences ETDs

This dissertation aims to determine if adult hippocampal neurogenesis is a potential therapeutic target in Fetal Alcohol Spectrum Disorders (FASDs). Adult hippocampal neurogenesis plays important and unique roles in certain aspects of learning, memory, and mood (Anacker & Hen, 2017). Individuals with FASDs often demonstrate dysregulation in these arenas (Lewis et al., 2015; Temple, Cook, Unsworth, Rajani, & Mela, 2019). Previous work in our lab using a mouse model of prenatal alcohol exposure demonstrated impairment in enrichment-mediated adult hippocampal neurogenesis (Irene Y. Choi, Andrea M. Allan, & Lee Anna Cunningham, 2005; K. Kajimoto, A. Allan, & L. A. Cunningham, 2013). …

Oil, Climate Change, And Human Rights: A Case Study Of Norway With Comparative Analysis, Kate Sjovold

Environmental Studies Senior Seminar Projects

The Arctic region is simultaneously facing profound, negative ecological impacts of climate change and is also subject to expanding oil and gas exploration and extraction. Facing a critical decision involving Arctic oil expansion, Norway is contending with its position as a global leader in the environmental movement and its historic and continued economic reliance on the oil and gas industry. This research contextualizes Norway within the Arctic region, discusses Norway as a petroleum exporting country, and addresses how value and identity play a role in environmental policy creation. Recent human rights-based climate change litigation in Norway, People v. Arctic Oil, …

More Than Just Video Games: Analyzing Japanese Game Design 1985 - 1995, Gerald Demattia

Seton Hall University Dissertations and Theses (ETDs)

This thesis is an exploration of how the Japanese experience in the second half of the 20^th century shaped video game design in Japan from 1985-1995 – particularly the formation of the Japanese role-playing game (JRPG) genre. To understand the connection between the Japanese experience and JRPGs, research for this thesis was conducted around specific game developers and their creations, namely: Yuji Horii and Dragon Quest; Shigesato Itoi and Mother 1 & 2; and Tajiri Satoshi and the Pokémon games. The crux of this paper centers on primary source interviews with developers where social commentary was cited …

The Covid-19 Pandemic: An Analysis Of Its Inequitable Impacts Towards The Black Population With Recommendations To Dismantling Institutional Racism, Elena Peterson

Master's Projects and Capstones

Due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the 2020 coronavirus disease pandemic uncovered health inequities throughout the United States. This paper explores institutional racism as the reasoning behind these health inequities. A discussion of the United States’ failure to implement preventative precautions once notified initially of the coronavirus is featured. Events that took place after the recognition of the coronavirus, such as the economic impacts and passed legislation, are highlighted as well. An overview of the Trump Administration’s lack of focus towards vulnerable populations, which includes the Black communities, is included. Also, there are highlights on …

Role Of The Acid Sensing Ion Channel 1a In The Systemic Circulation, Selina M. Garcia

Biomedical Sciences ETDs

Acid-sensing ion channel 1a (ASIC1a) is a non-selective cation channel that is expressed in vascular smooth muscle cells. However, little is known about the contribution of ASIC1a to vascular reactivity and cardiovascular homeostasis. We have previously shown that ASIC1a contributes to pulmonary vascular smooth muscle cell (VSMC) Ca²⁺ entry and vasoconstriction as well as chronic hypoxia-induced pulmonary hypertension. However, a role of ASIC1a in the systemic circulation is unclear. Previous reports have shown that ASIC1a is expressed in femoral and cerebral arteries, however, these studies suggest that ASIC1a contributes to vascular reactivity through neuronal regulation rather than vascular. Therefore, …

The Role Of Anti-Inflammatory Cytokine Interleukin-10 (Il-10) In Tauopathies, Lea L. Weston

Biomedical Sciences ETDs

Tauopathies are neurodegenerative diseases, including Alzheimer’s disease, that are associated with pathological accumulation of the microtubule associated protein tau (MAPT, or tau) (Lee et al., 2001). Abnormal hyperphosphorylated tau (pTau) strongly correlate with cognitive impairment (Nelson et al., 2012). Neuroinflammation is also associated with tauopathies (Gerhard et al., 2006b; Edison et al., 2008) and is implicated in driving tau pathology (Yoshiyama et al., 2007, Maphis et al., 2015b). Therefore, it is compelling to understand the role of anti-inflammatory cytokines in limiting neuroinflammation and tau pathology. Interleukin-10 (IL-10) is a well-established anti-inflammatory cytokine with roles in limiting inflammation in the central …

When The Clinical Environment Is Closed To Students: The Harsh Reality Of Covid-19 And Implications For Colleges Of Osteopathic Medicine, Ken Heiles, Valerie Sheridan, Tami Hendriksz, Rebecca Giusti, Tyler C. Cemet

Faculty and Staff Publications

When the World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) a global health emergency, Colleges of Osteopathic Medicine (COMs) debated the role of medical students during this developing pandemic. Initially, the discussion included whether medical students were essential personnel contributing to meaningful patient care. Many questions arose regarding how COVID-19 would affect medical education and if the changes would be temporary or continue for a significant period of time. Due to the lack of availability of personal protective equipment (PPE) and a decreased focus on clinical education within many healthcare settings, in March the American Association of Colleges of …

Bibliometric Survey On Effects Of Climate Change On Incidences Of Infectious Diseases, Seema Harshad Patil, Yatharth Jain, Vedant Marathe

Library Philosophy and Practice (e-journal)

^{For understanding the influx of Infectious Diseases, research of climate change and its effects pertaining to the diseases is important. The motive of this bibliometric survey is to understand the research which has been carried out regarding the aforementioned topics. This paper summarizes the research in the 21st Century from 2001 to present. We conducted this analysis using tools such as Gephi, Researchgate, Scopus, ScienceScape, Google Scholar and Mapchart. This Bibliometric Survey on “Effects of Climate Change on Infectious Diseases” showed that maximum publications are articles. These publications are from conferences and journals related to Environmental Science. The United States …}

Current Available Computer-Aided Detection Catches Cancer But Requires A Human Operator, Florentino Saenz Rios, Giri Movva, Hari Movva, Quan D. Nguyen

School of Medicine Publications

Introduction: This study intends to show that the current widely used computer-aided detection (CAD) may be helpful, but it is not an adequate replacement for the human input required to interpret mammograms accurately. However, this is not to discredit CAD’s ability but to further encourage the adoption of artificial intelligence-based algorithms into the toolset of radiologists.

Methods: This study will use Hologic (Marlborough, MA, USA) and General Electric (Boston, MA, USA) CAD read images provided by patients found to be Breast Imaging Reporting and Data System (BI-RADS) 6 from 2019 to 2020. In addition, patient information will be pulled …

Diamond Line - Fall 2020, Autumn Blaylock, Emily Corn, Heather Drouse, Claire Hutchinson, Elise Lusk, Alexis Jamilee Carter, Lauren Dial, Toby James Haymore, Caroline Jennings, Heidi Kirk, Brittaney Mann, Anna Karen Olivo, Hadley West, Tabitha Novotny, Lexie Price

Diamond Line Undergraduate Literary Magazine

In following up the premier issue of The Diamond Line, the fall 2020 editorial staff had big shoes to fill. We took on the challenge of creating something that would uphold the framework of Issue 1 while simultaneously branching out from its margins.

Like the editors before us, we had a vision, but ours took a new form — bright, warm colors. Sunset colors. Moons. Playful lines. Isolation and introspection. A stroll through an art gallery. A coming-of-age story bound between two groovy orange bookends. While Issue 2 does not have an overarching theme, we chose the cover art, “Pandemic …

Impact Of Italian Ryegrass (Lolium Multiflorum Lam.) Management On The Parasite Burden In Sheep, Cesar H. E. C. Poli, E. J. Pegorar, P. C. De F. Carvalho, M. J. T. De M. Gomes, V. Fischer, D. B. Montano

IGC Proceedings (1977-2023)

No abstract provided.

Pastoral Systems Changing From Conventional To Social Agriculture In Mediterranean Italy, Andrea Pardini, V. Pratesi, F. Baronti

IGC Proceedings (1977-2023)

No abstract provided.

Forage Mass, Carrying Capacity And Daily Weight Gain Of Crossbred Heifers In Silvopastoral System Or Exclusive Signalgrass Pasture, Domingos S. C. Paciullo, L. J. M. Aroeira, M. J. Alvim, F. J. N. Costa

IGC Proceedings (1977-2023)

No abstract provided.

An Online Resource To Promote Well-Being Among College Students With Social Anxiety Disorder, Valerie Maxine Sanderson, Steven M. Gerardi, Jerilyn Callen

Fall 2020 Virtual OTD Capstone Symposium

Transitioning from high school to college can be a challenge for many students, especially those with social anxiety disorder (SAD). SAD can negatively impact a student’s ability to effectively participate in school. Occupational therapy intervention could be useful to students with SAD but many do not seek out treatment due to fear of stigmatization or discrimination. Not seeking services may place students with SAD at risk of developing unhealthy coping strategies (e.g., avoidant behaviors, alcohol use). The availability of an online resource to support participation in school, without the need to disclose their condition, could be helpful to students with …

Prevalence Of Snake Fungal Disease Caused By Ophidiomyces Ophiodiicola In East Texas, Alan Lizarraga

Biology Theses

Fungal pathogens and resultant disease are credited with the decline of many species across all branches of the tree of life. Fungal diseases such as Snake Fungal Disease (SFD), primarily caused by the fungus Ophidiomyces ophiodiicola (Oo), have been strongly associated with the cause of the decrease/disappearance of many snake populations in North America. To date SFD in the wild has been described as far southwest as central Louisiana. Due to similar conditions and the proximity of East Texas to central Louisiana, a survey of local snake populations provided crucial information about the spread and presence of this emerging pathogen. …

Wildlife Conservation And Hunting Nrs 455, Michael Cerbo

Library Impact Statements

No abstract provided.

Classification Of Small Ruminant Lentivirus Subtype A2, Subgroups 1 And 2 Based On Whole Genome Comparisons And Complex Recombination Patterns, Aaron M. Dickey, Timothy P.L. Smith, Michael L. Clawson, Michael P. Heaton, Aspen M. Workman

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Background: Small ruminant lentiviruses (SRLVs) cause a multisystemic chronic wasting disease in sheep across much of the world. SRLV subtype A2 is prevalent in North America and further classified into multiple subgroups based on variation in the group antigens gene (gag) and envelope (env) genes. In sheep, the ovine transmembrane protein 154 (TMEM154) gene is associated with SRLV susceptibility. Ewes with at least one copy of TMEM154 encoding a fulllength protein with glutamate at position 35 (E35; haplotypes 2 and 3), are highly susceptible to SRLV infection while ewes with any combination of TMEM154 …

Yy1 Directly Interacts With Myocardin To Repress The Triad Myocardin/Srf/Carg Box-Mediated Smooth Muscle Gene Transcription During Smooth Muscle Phenotypic Modulation, Jian-Pu Zheng, Xiangqin He, Fang Liu, Shuping Yin, Shichao Wu, Maozhou Yang, Jiawei Zhao, Xiaohua Dai, Hong Jiang, Luyi Yu, Qin Yin, Donghong Ju, Claire Li, Leonard Lipovich, Youming Xie, Kezhong Zhang, Hui J. Li, Jiliang Zhou, Li Li

Orthopedics Articles

Yin Yang 1 (YY1) regulates gene transcription in a variety of biological processes. In this study, we aim to determine the role of YY1 in vascular smooth muscle cell (VSMC) phenotypic modulation both in vivo and in vitro. Here we show that vascular injury in rodent carotid arteries induces YY1 expression along with reduced expression of smooth muscle differentiation markers in the carotids. Consistent with this finding, YY1 expression is induced in differentiated VSMCs in response to serum stimulation. To determine the underlying molecular mechanisms, we found that YY1 suppresses the transcription of CArG box-dependent SMC-specific genes including SM22α, SMα-actin …

An Evaluation Of Adolescent Concussion Management And Guidelines By Primary Care Providers In The Outpatient Setting: Dnp Scholarly Project, Mary Beth Newkirk

Doctor of Nursing Practice Scholarly Project

Understanding the pathology of a concussion has been a challenging task for many experts in healthcare. An agreed upon definition has yet to be developed and many health care providers are not properly educated to assess and care for those suffering from a concussion. Management of concussion in adolescents, a vulnerable population, requires even more consideration and training. The purpose of this study was to determine the knowledge current providers in the four-state region regarding sport-related concussion management in the adolescent population, to improve patient care and outcomes, and to improve knowledge learned through exposure to a clinical practice guideline-based, …

Virtual And In Vitro Antiviral Screening Revive Therapeutic Drugs For Covid-19, Giovanni Bocci, Steven B. Bradfute, Chunyan Ye, Matthew J. Garcia, Jyothi Parvathareddy, Walter Reichard, Surekha Surendranathan, Shruti Bansal, Cristian G. Bologa, Douglas J. Perkins, Colleen B. Jonsson, Tudor I. Oprea, Larry A. Sklar

Pathology Research and Scholarship

The urgent need for a cure for early phase COVID-19 infected patients critically underlines drug repositioning strategies able to efficiently identify new and reliable treatments by merging computational, experimental, and pharmacokinetic expertise. Here we report new potential therapeutics for COVID-19 identified with a combined virtual and experimental screening strategy and selected among already approved drugs. We used hydroxychloroquine (HCQ), one of the most studied drugs in current clinical trials, as a reference template to screen for structural similarity against a library of almost 4000 approved drugs. The top-ranked drugs, based on structural similarity to HCQ, were selected for in vitro …

The Flowering Of Ecology: Maria Sibylla Merian's Caterpillar Book, Kay Etheridge

Gettysburg College Faculty Books

The Flowering of Ecology presents an English translation of Maria Sibylla Merian’s 1679 ‘caterpillar’ book, Der Raupen wunderbare Verwandelung und sonderbare Blumen–Nahrung. Her processes in making the book and an analysis of its scientific content are presented in a historical context. Merian raised insects for five decades, recording the food plants, behavior and ecology of roughly 300 species. Her most influential invention was an 'ecological' composition in which the metamorphic cycles of insects (usually moths and butterflies) were arrayed around plants that served as food for the caterpillars. Kay Etheridge analyzes the 1679 caterpillar book from the viewpoint of …

Synthesis Of The Oxidative Metabolites Of Di(2-Ethylhexyl) Phthalate And Analysis Of Metabolite Binding With Peroxisome Proliferator-Activated Receptors, Alexis Brooner

Departmental Honors & Graduate Capstone Projects

Di(2-ethylhexyl) phthalate (DEHP) is a persistent organic pollutant that is added to increase the flexibility of soft plastics, such as polyvinyl chloride (PVC). Since DEHP is not bound to the polymer, it leaches into the environment, leading to human exposure. When DEHP is metabolized by the body, it is cleaved into mono-(2-ethylhexyl) phthalate (MEHP). MEHP is then oxidized to produce the secondary-oxidized metabolites mono-(2-ethyl-5-carboxypentyl)phthalate (5cx-MEPP), mono-(2-ethyl-5-oxohexyl)phthalate (5oxo-MEHP), and mono-[2-(carboxymethyl)hexyl]phthalate (2cx-MMHP). DEHP and its metabolites interact with peroxisome proliferator-activated receptors (PPARs), which can alter lipid metabolism. To synthesize 5cx-MEHP, an enolate alkylation was performed with ethyl butyrate to form ethyl 2-ethyl-6-heptenoate. …

Bringing Batavia Armory Building Back To Life – Community Center Adaptive Reuse Design, Jiangcheng Li

Theses

Built in 1963 and situated on a 4.6-acre lot in the City of Batavia, the Batavia Armory once housed tank battalions A and B of the Genesee National Guard, but has now remained vacant for decades. Instead of demolishing the armory buildings, providing them with a new role could alleviate the environmental impact, reduce construction time, and lower the cost of investment. At the same time, new features could be brought into the existing building from aesthetic and functional perspectives, and be beneficial to the community. Currently, we are facing the COVID-19 pandemic, and the virus impacts our lives and …

Exposure To Pesticides And Hepatocellular Carcinoma (Hcc) Risk In And Around Monroe County, Ny, Theodros Woldeyohannes

Theses

The impact of long-term exposure and persistence of pesticides in the environment on human biology is not completely understood. With the proliferation of pesticide application technologies, there have been documented associations between exposure to every major functional group of pesticide and adverse health effects in humans such as cancer and neurological disease. Of observed pesticide-induced cancer health-risks, hepatocellular carcinoma (HCC) has shown some of the most significant associations. Epidemiological study is complex, especially when examining pesticide health risks. It is difficult to understand the significance behind interactions between the large list of pesticide compounds, external environmental factors, and biological variables. …

Valley Fever: Education For Primary Care Providers And Allied Health Care Professionals, Michelle Elizabeth Bergen

Doctor of Nursing Practice (DNP) Projects

Valley Fever: Educating Primary Care Providers and Allied Healthcare Professionals

Abstract

Problem: Coccidioidomycosis (cocci), informally Valley Fever (VF), infects the lungs with the fungal spore coccidioides. It is prevalent in areas where soil disturbance occurs. Currently, there are no related educational or standardized guidelines exist for primary care providers (PCPs) in California’s Central Valley, where VF is highly endemic (Centers for Disease Control and Prevention, 2018).

Context: A Doctor of Nursing Practice project educational program for PCPs and allied healthcare workers (AHWs) at the Adventist Health Central Valley Network (AHCVN) clinics. The project aimed to educate PCPs to …

Characterizing Patterns In Texas Gulf Coast Beach Dune Plant Species Composition, Cody Foster

Electronic Theses and Dissertations

Regional vegetation patterns of Texas beach plant communities were analyzed using cluster analysis, ANOSIM, SIMPER, NMDS, and ISA for fives zones representing the foredune complex of twenty Gulf Coast beaches. ANOVA revealed that zones differ in terms of percent bare sand, percent vegetative cover, and species richness. Cluster Analysis, ANOSIM, and SIMPER results indicate that Texas beaches can be divided into northern and southern regions based on differences in species composition of plant communities. Indicator Species Analysis (ISA) indicates that northern beaches are characterized by the presence of Rayjacksonia phyllocephala, Ambrosia Strophostyles, Ambrosia psilostachya, and Panicum amarum …

To Reach The Unreachable Stars: Reexamining The Shared Arthurian Vision Of C. S. Lewis's Science Fiction Trilogy And Raymond Chandler's Marlowe Novels, Hollis Thompson

Electronic Theses and Dissertations

Although Raymond Chandler and C. S. Lewis seem to be a rather strange pairing, the ways in which they both borrow from Arthurian literature and use the myth to speak to their cultural moment are strikingly similar. Following T. S. Eliot’s use of the Grail quest in The Waste Land (which set a standard for the use of such material in Modern literature), these authors use Arthurian elements as a means of exposing hidden connections between the fragments of the literary past and the present within Chandler’s Marlowe novels and Lewis’s science fiction trilogy. Both men present Western identity as …

Impact Of Cd82 Expression On Acute Myeloid Leukemia Chemosensitivity And Quiescence, Muskan Floren

Biomedical Sciences ETDs

Acute Myeloid Leukemia (AML) patients respond favorably to induction chemotherapy, however, long-term outcomes remain poor due to a high rate of chemoresistance and bone marrow minimal residual disease. To improve long-term patient outcomes, it’s critical to identify regulators of chemotherapy resistance in AML and develop therapies that are directed towards bone marrow resident AML cells. In Chapter 2, we uncover the impact of CD82 expression in AML response to chemotherapeutic treatment and the contribution of Protein Kinase C α (PKCα) and β1 integrin signaling in promoting p38 MAPK activation to support CD82-mediated AML cell survival. In Chapter 3, we …

The Evolution Of A Tropical Biodiversity Hotspot, M G. Harvey, G A. Bravo, S Claramunt, A M. Cuervo, M G. Harvey, J Battilana, G F. Seeholzer, J S. Mckay, B C. O'Meara, B C. Faircloth, S V. Edwards, J Perez-Eman, R G. Moyle, F H. Sheldon, A Aleixo, B T. Smith, R T. Chesser, L F. Silveira, J Cracraft, R T. Brumfield, E P. Derryberry

Faculty Publications

The tropics are the source of most biodiversity yet inadequate sampling obscures answers to fundamental questions about how this diversity evolves. We leveraged samples assembled over decades of fieldwork to study diversification of the largest tropical bird radiation, the suboscine passerines. Our phylogeny, estimated using data from 2389 genomic regions in 1940 individuals of 1287 species, reveals that peak suboscine species diversity in the Neotropics is not associated with high recent speciation rates but rather with the gradual accumulation of species over time. Paradoxically, the highest speciation rates are in lineages from regions with low species diversity, which are generally …

Functional Investigations Of Proteins And Enzymatic Toxins From Full-Length-Enriched Cdna Of Timber Rattlesnake (Crotalus Horridus), Joshua Osula

Theses

Snake Venom is a highly modified form of saliva, contains hundreds of zootoxins, necrotoxins, cytotoxins, neurotoxins, and mytotoxins, all of which are primarily made up of mostly proteins, polypeptides, and other components such as enzymes, lipids, and carbohydrates. Although snake venom is known for its harmful effects, it has also had a positive impact in scientific discovery and medicine. Some toxins from snakes function to inhibit pain, and this means they can be very effective analgesics. For instance, crotalphine is considered a 14-amino-acid-peptide that has a disulfide bond and shows analgesic properties through TRPA1 desensitization. This …