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Full-Text Articles in Entire DC Network
Towards Identifying Fear And Safety Network States Across Sex, Rhonda Kolaric
Towards Identifying Fear And Safety Network States Across Sex, Rhonda Kolaric
Dissertations, Theses, and Capstone Projects
Post-traumatic stress disorder (PTSD) is a trauma- and stressor-related disorder with a lifetime prevalence of 5-6% in men, and 10-12% in women (National Center for PTSD). Generalized anxiety disorder (GAD) is a highly prevalent anxiety- and depression-related psychiatric disorder with a lifetime prevalence of 1-2% in men, and 3-4% in women (National Institutes of Health). Both of these disorders disproportionately affect women. A hallmark feature of both disorders is the maladaptive generalization of fear, in which defensive responses extend beyond the original traumatic or threatening stimulus to neutral or unrelated cues. This overgeneralization can become debilitating, disrupting cognitive, emotional, and …
Symphonies That "Sing": Reevaluating Voices And Vocality In Mahler's Early Symphonies, Erin M. Johnston
Symphonies That "Sing": Reevaluating Voices And Vocality In Mahler's Early Symphonies, Erin M. Johnston
Dissertations, Theses, and Capstone Projects
This dissertation considers the role of vocal music in Gustav Mahler’s early symphonies through the lens of the composer’s practice of self-borrowing. Mahler was known to use his own pre-existing songs as the basis for large-scale movements in his early symphonies. While scholars have long recognized the close relationship between Mahler’s songs and symphonies, existing studies have emphasized questions of biography, intertextuality, musical meaning, and quotation rather than sustained analytical investigations of vocal influence in Mahler’s large-scale symphonic forms. The present study places this vocality at the forefront of its analyses, arguing that Mahler’s reworking of his own Lieder is …
Guide To The Crawford-Beck Vineyard Collection, Linfield University Archives
Guide To The Crawford-Beck Vineyard Collection, Linfield University Archives
Linfield Archives Finding Aids
In 2005, David Beck and Jeanne Crawford purchased Casa-Blanca Vineyard and renamed it as Crawford-Beck Vineyard and owned it for 17 years. This collection focuses on the evolution of Crawford-Beck Vineyards from 2005 to 2023. It contains multiple business documents and records, such as expansion plans, invoices, and LIVE evaluation records. The collection also explores the personal growth and achievements of David and Jeanne Beck, the owners of Craw-Beck Vineyard. This includes their enrollment at Chemeketa Community College, their involvement in the wine industry in Oregon, and their personal assortment of books and articles. The collection also contains material outside …
Autonomy, Adolescents, And Artificial Intelligence, Michael J. S. Beauvais
Autonomy, Adolescents, And Artificial Intelligence, Michael J. S. Beauvais
Journal of Science & Technology Law
In this essay, I explore the potential implications of adolescent use of AI assistants on the development of adolescents’ capacities for autonomy. Thinking through these issues from the perspective of first principles is, I believe, needed in order to sharpen our understanding of some of the issues AI assistants pose for young people. A clear analysis will suggest which legal or policy prescriptions should follow.
I first give an overview of adolescent use of AI assistants, noting their popularity and the variety of use contexts. Drawing upon the work of Catriona Mackenzie, I then outline a relational conception of autonomy …
Ai Slop, Jessica Silbey, Woodrow Hartzog
Ai Slop, Jessica Silbey, Woodrow Hartzog
Faculty Scholarship
The term “AI slop” has become popular to describe the output of generative AI systems seen as voluminous, low quality, or the result of little effort. When AI-generated music and videos flood platforms, they are called slop. Peer-reviewed journals and legal tribunals are drowning in low-quality and low-reliability AI slop submissions. Employees are seen to be producing mountains of slop in their reports and communications with each other. The term has inertia and heft, and the phenomenon has significant consequences. Most of them are not good.
But the boundaries of “AI slop” and its usefulness in policy discussions are not …
Nonverbal Communication In New York Fashion Week, Lianna Cruz, Maia Coyle
Nonverbal Communication In New York Fashion Week, Lianna Cruz, Maia Coyle
Proceedings of the New York State Communication Association
Nonverbal communication research has largely explored materiality and performance independently, leaving their joint role in meaning-making underexamined. The authors applied Langerian aesthetic theory and examined how three key kinesic variables intersect with clothing to create significance and symbolism by asking, “How do rhythm, body movement, and dance build meaning in New York Fashion Week?” Following Langer and Edward T. Hall, we conducted close visual analyses of three Spring and Fall 2025 New York Fashion Week shows: Coach, Off-White, and Thom Browne. Findings indicate that these variables build meaning by creating degrees of professionalism, reinforcing meanings through clothes, and renegotiating meanings …
Molecular Detection Of Staphylococcus Aureus: A Performance Comparison Of Colony Pcr And Conventional Pcr Targeting The Icab Gene, Farah Badri Abed, Shahrazad Hazim Muhi, Sahar Mustafa Ibrahim, Riyam Alaa Mohammed
Molecular Detection Of Staphylococcus Aureus: A Performance Comparison Of Colony Pcr And Conventional Pcr Targeting The Icab Gene, Farah Badri Abed, Shahrazad Hazim Muhi, Sahar Mustafa Ibrahim, Riyam Alaa Mohammed
Muthanna Medical Journal
Background: Staphylococcus aureus is an important nursing disease that requires a prompt and effective diagnosis to implement a strategy to curb its transmission and spread. Although the gold standard is the conventional PCR using column-purified genomic DNA, Colony PCR with crude cell lysates saves a lot of time and cost of the test and its performance features have not been well established.
Objectives: This paper will compare Colony PCR (boiling method) and Conventional PCR (ABIOpuretm kit extraction) to amplify icaB gene (141 bp), which is a major determinant of biofilm formation in S. aureus and then assess their application with …
Bathurst Burr And Its Control, Department Of Primary Industries And Regional Development, Western Australia
Bathurst Burr And Its Control, Department Of Primary Industries And Regional Development, Western Australia
Biosecurity factsheets
Bathurst burr (Xanthium spinosum) is a declared pest in Western Australia (WA). This factsheet describes the nature of the plant, requirements land owners/occupiers must adhere to, control methods, and how to search, detect, and report it.
Bathurst burr is a summer growing annual shrubby plant originating in South America. In south west Australia, some mature plants survive well into winter, with the result that burrs may be found for most of the year. The weed spreads entirely by burrs, which are usually carried by people or animals, attached to clothes, fur, or other fibre by their hooked spines. They may …
Noogoora Burr And Its Control, Department Of Primary Industries And Regional Development, Western Australia
Noogoora Burr And Its Control, Department Of Primary Industries And Regional Development, Western Australia
Biosecurity factsheets
Noogoora burr, also known as cocklebur (Xanthium strumarium), is a declared pest in Western Australia (WA). This factsheet describes the nature of the plant with links to requirements that land owners/occupiers must adhere to and control methods.
Native to western United States of America. Locally abundant in parts of the Kimberley, especially near water courses. Occasionally found in the South West region of WA.
The Prospector, September 1, 2026, Student Publications
The Prospector, September 1, 2026, Student Publications
The Prospector
No abstract provided.
Organic Pesticides: A General Overview, Marion Murray, Ann Mull
Organic Pesticides: A General Overview, Marion Murray, Ann Mull
All Current Publications
Organic pesticides are naturally occurring, nonsynthetic, or minimally processed substances that control unwanted organisms in the environment. Categories include insecticides, herbicides, fungicides, and miticides.
Longitudinal Association Between Midlife Cardiovascular Health And Cognitive Change In A Bi-Ethnic Cohort, Janette Vazquez, Rebecca Bernal, Luis Aguirre, Jesus D. Melgarejo, Gladys Maestre, Sudha Seshadri, Helen P. Hazuda, Chen-Pin Wang, Claudia Satizabal
Longitudinal Association Between Midlife Cardiovascular Health And Cognitive Change In A Bi-Ethnic Cohort, Janette Vazquez, Rebecca Bernal, Luis Aguirre, Jesus D. Melgarejo, Gladys Maestre, Sudha Seshadri, Helen P. Hazuda, Chen-Pin Wang, Claudia Satizabal
School of Medicine Publications
Introduction: Midlife cardiovascular burden contributes to cognitive decline and dementia. However, research in diverse populations remains scarce.
Methods: We included 402 San Antonio Heart Study participants (1979–1988; midlife mean age 57.9 ± 3.8, 58.5% women, 52% Mexican American) later enrolled in the San Antonio Longitudinal Study of Aging (1992–2004). Midlife cardiovascular health was assessed using Life's Simple 7. Cognition was measured up to four times with the Mini-Mental State Examination. Generalized estimating equation models adjusted for age, sex, income, and education were used to relate cardiovascular factors to cognitive change. Sensitivity analyses evaluated attrition bias.
Results: Physical activity was associated …
Diversity And Species Richness Of Lepidopteran Stemborers And Their Host Plants Across Major Vegetation Mosaics Of East Africa, Elie Ntirenganya, Muluken Goftishu, Yoseph Assefa, Bonoukpoè Mawuko Sokame, Simon Boniface Boni, Janvier Uwayezu, Hategekimana Athanase, Venuste Nsengimana
Diversity And Species Richness Of Lepidopteran Stemborers And Their Host Plants Across Major Vegetation Mosaics Of East Africa, Elie Ntirenganya, Muluken Goftishu, Yoseph Assefa, Bonoukpoè Mawuko Sokame, Simon Boniface Boni, Janvier Uwayezu, Hategekimana Athanase, Venuste Nsengimana
All Peer-Reviewed Publications
The study was carried out in the major ecological vegetation mosaics of Rwanda, including Afro-alpine mountain mosaics within the Guineo–Congolese region in the north; Akagera sub-humid savanna mosaics in the east; montane forest mosaics in the south; and modified urban wetland and riparian mosaics of Kigali City, within the Sudanian–Guinea–Congo transition zone. At each selected locality, purposive sampling in (i) edges of the cultivated field and adjacent uncultivated lands, (ii) open patches along the forest access roads and pathways, (iii) riparian zones along urban areas, rivers, and streams, (iv) edge of lakes, and (v) swamp ecosystems was conducted to detect …
Quantile Normalisation Enables Interpretable Spatial Prioritisation Of Persistence-Related Mechanistic Suitability Under Uncertainty For Tomato Red Spider Mite (Tetranychus Evansi) In Africa, Komi Mensah Agboka, Luca Rossini, Quinto Juma Meltus, Bonoukpoè Mawuko Sokame, Abdulmutallab G.A. Azrag, Thomas Dubois, Elfatih M. Abdel-Rahman
Quantile Normalisation Enables Interpretable Spatial Prioritisation Of Persistence-Related Mechanistic Suitability Under Uncertainty For Tomato Red Spider Mite (Tetranychus Evansi) In Africa, Komi Mensah Agboka, Luca Rossini, Quinto Juma Meltus, Bonoukpoè Mawuko Sokame, Abdulmutallab G.A. Azrag, Thomas Dubois, Elfatih M. Abdel-Rahman
All Peer-Reviewed Publications
Mechanistic trait models are increasingly considered to estimate persistence-related suitability for invasive species, although translating reproduction metrics into operational indicators for spatial decision-making remains challenging. Branching-process transformations are widely applied to convert mechanistic reproduction numbers into probabilities of establishment; however, such transformations may compress spatial gradients when persistence is broadly feasible. Using tomato red spider mite (Tetranychus evansi) as a case study across Africa, this study developed an uncertainty-aware, physiologically-based model and generated spatially explicit estimates of expected reproduction (R0). We compared three representations: raw mechanistic suitability, branching-process persistence probability, and quantile-normalised suitability. Although all representations preserved rank ordering, branching …
Pornography And Men's Violence Against Women And Children: From Production To Consumption, Gail Dines Phd., Mandy Sanchez Phd
Pornography And Men's Violence Against Women And Children: From Production To Consumption, Gail Dines Phd., Mandy Sanchez Phd
Dignity: A Journal of Analysis of Exploitation and Violence
The average age of first viewing mainstream pornography for boys is around ten to twelve years old. The pornography they encounter is largely from “tube sites,” named after YouTube, which are popular because they require no registration, no payment, and no subscription. For the most part, an adolescent only needs access to a digital device to view hundreds of thousands of free videos. As we discuss in this article, the weight of the scientific evidence shows that viewing pornography is associated with multiple social, emotional, sexual, and cognitive harms. However, none of these studies provide a detailed analysis of …
A History Of University Of Rhode Island Partnerships In The Philippines With Marine Resources And Fisheries Management As Primary Drivers, Michael A. Rice, Donald D. Robadue, Brian Crawford
A History Of University Of Rhode Island Partnerships In The Philippines With Marine Resources And Fisheries Management As Primary Drivers, Michael A. Rice, Donald D. Robadue, Brian Crawford
Fisheries, Animal and Veterinary Sciences Faculty Publications
No abstract provided.
An Investigative Approach Leveraging Digital Twin Technology For A Cnc Machine, Anand Valiavalappil
An Investigative Approach Leveraging Digital Twin Technology For A Cnc Machine, Anand Valiavalappil
Yanbu Journal of Engineering and Science
Digital twin technology has emerged as an effective approach for improving the monitoring, validation, and optimization of Computer Numerical Control (CNC) machining operations. This study presents an investigative framework integrating Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM), Software-in-the-Loop (SIL), and Hardware-in-the-Loop (HIL) methodologies for diagnosing and rectifying machining defects in CNC systems using the digital twin - virtual model (component and asset twins). Four machining experiments were conducted using Aluminum 6061-T6, Polytetrafluoroethylene (PTFE), Brass, and Stainless Steel (AISI 304) on an EMCO CNC machine integrated with Siemens 840D controls. The first two experiments, involving turning and drilling operations, are presented in detail; the …
Investigating How Personal Values Shape Tourism Experiences: A Case Study Of The Irish National Stud And Gardens, Amy Monahan, Ann T. Conway
Investigating How Personal Values Shape Tourism Experiences: A Case Study Of The Irish National Stud And Gardens, Amy Monahan, Ann T. Conway
International Journal of Tour Guiding and Visitor Attraction Research
This Paper explores the relationship between personal values and tourism experiences that are satisfying. A case study of the Irish National Stud and Gardens was undertaken in order to explore this concept. Interviews were conducted to investigate how qualities of the attraction appealed to the visitors’ personal values, thereby enhancing the overall visitor experience. A set of personal values were identified which were specific to the destination. The research demonstrated how an understanding of personal values can assist attractions with various aspects of their operations, with context specific recommendations provided at the end. This approach was taken was taken to …
Coming Soon To A Cellar Near You: Novel Range Expansion Of A Short-Bodied Cellar Spider, Physocyclus Enaulus (Araneae: Pholcidae), In A Building In Central Illinois, Usa, Ricky Gieser, Mark Davis
Coming Soon To A Cellar Near You: Novel Range Expansion Of A Short-Bodied Cellar Spider, Physocyclus Enaulus (Araneae: Pholcidae), In A Building In Central Illinois, Usa, Ricky Gieser, Mark Davis
The Great Lakes Entomologist
A reproductive population of Physocyclus enaulus Crosby, 1926 (Pholcidae: Araneae), a short-bodied cellar spider native to the American southwest and Mexico, is documented for the first time in a single building in Illinois, far outside of their known native range. The means of introduction is unknown but is likely influenced by either accidental hitchhiking spiders or a deliberate introduction to control brown recluse populations. Cellar spiders were purchased and released in the same building to predate on brown recluse spiders, but the first P. enaulus individual was found a year prior to the release. These cellar spiders have a wide-ranging …
Paper Wasp Species Polistes Fuscatus (Hymenoptera: Vespidae) Tracks Urban Lead (Pb) Levels More Than Polistes Dominula, Lindsey R. Kemmerling, Anna L. Lovat, Allison A. Hanka, Emilie C. Snell-Rood
Paper Wasp Species Polistes Fuscatus (Hymenoptera: Vespidae) Tracks Urban Lead (Pb) Levels More Than Polistes Dominula, Lindsey R. Kemmerling, Anna L. Lovat, Allison A. Hanka, Emilie C. Snell-Rood
The Great Lakes Entomologist
Lead (Pb) is a persistent, toxic pollutant with widespread but inequitably distributed impacts, especially for humans in urban areas. The impacts of lead pollution on other organisms is largely unknown, even as they commonly experience exposure to lead alongside humans. We tested hypotheses regarding the lead concentrations of paper wasps across a gradient of pollution relative to soil and human lead levels, and correlations with wasp body condition. We collected two species of paper wasp across an urban gradient of lead pollution: Polistes fuscatus (Fabricius) (Hymenoptera: Vespidae), native to our study location, and Polistes dominula (Christ), nonnative to our study …
Long-Term Monitoring And Response Of Papaipema Sciata Bird (Lepidoptera: Noctuidae) To Prescribed Fire In Michigan (Usa), Gregory J. Norwood, Logan M. Rowe, Brett A. Degregorio, David L. Cuthrell, Aaron D. Meredith, Steven M. Gray
Long-Term Monitoring And Response Of Papaipema Sciata Bird (Lepidoptera: Noctuidae) To Prescribed Fire In Michigan (Usa), Gregory J. Norwood, Logan M. Rowe, Brett A. Degregorio, David L. Cuthrell, Aaron D. Meredith, Steven M. Gray
The Great Lakes Entomologist
The Culver’s root borer moth (Papaipema sciata) (Lepidoptera: Noctuidae) is a rare Noctuid that requires Culver’s root (Veronicastrum virginicum) to complete its lifecycle within remnant native grasslands and open woodlands in the midwest and northeast United States. We report on 26 years of monitoring this species’ colonization of Culver’s root stems at Algonac State Park (ASP) in Michigan, where prairies have been maintained by prescribed fire since 1990. P. sciata is considered fire sensitive because eggs spend the dormant season in the combustible prairie litter and duff near host plants. The objectives were to determine the …
Could The European Thanasimus Formicarius Outcompete The North American Thanasimus Dubius (Coleoptera: Cleridae) If Introduced To North America?, Robert A. Haack, Robert K. Lawrence
Could The European Thanasimus Formicarius Outcompete The North American Thanasimus Dubius (Coleoptera: Cleridae) If Introduced To North America?, Robert A. Haack, Robert K. Lawrence
The Great Lakes Entomologist
A federal quarantine was enacted in the United States (US) in the fall of 1992 in response to discovery of the Eurasian pine shoot beetle, Tomicus piniperda (L.) (Coleoptera: Scolytinae), in July 1992 in Ohio. The quarantine regulated movement of pine products (e.g., Christmas trees, nursery stock, and logs) at the county level from infested to uninfested US states. A classical biological program was considered for T. piniperda starting in 1995, focusing on the Eurasian clerid beetle Thanasimus formicarius (L.), an important predator of T. piniperda. Concerns were raised in 1996 that if T. formicarius were released in the …
Fecundity Of Thanasimus Dubius (Coleoptera: Cleridae) Rebounds After A Period Of Prey Scarcity, Robert A. Haack, Robert K. Lawrence
Fecundity Of Thanasimus Dubius (Coleoptera: Cleridae) Rebounds After A Period Of Prey Scarcity, Robert A. Haack, Robert K. Lawrence
The Great Lakes Entomologist
We field-collected Thanasimus dubius (Fabricius) (Coleoptera: Cleridae) adults during spring, maintained them separately in the laboratory, and initially gave them four bark beetle adults [Ips grandicollis (Eichhoff) or Tomicus piniperda (L.) (Coleoptera: Curculionidae: Scolytinae)] daily as prey. Using a subset of the female clerids (N = 41), we assigned them to one of four feeding groups that varied in the number of prey provided daily. For the first four weeks of a 12–week study, the four diets were: four prey daily, two prey daily, one prey daily, and one prey every 2 days. After four weeks, all females were …
Volume 9 (2026) Climate And Responsibility
Volume 9 (2026) Climate And Responsibility
International Journal on Responsibility
This issue focuses on the various ways responsibility affects environmental justice. Specifically, this volume urges us to think about how societal and individual (in)action influences ecological crises and what informs this behavior, with a specific focus on religious and Indigenous beliefs and values.
Solar-Driven Photocatalytic Ceramic Membrane Reactors For Paracetamol Degradation: Process Optimization, Transport Dynamics, And Preliminary Cyclic Reusability, Adel Zrelli, Asma Abdennebi, Manoj Chandra Garg, Fanghua Li
Solar-Driven Photocatalytic Ceramic Membrane Reactors For Paracetamol Degradation: Process Optimization, Transport Dynamics, And Preliminary Cyclic Reusability, Adel Zrelli, Asma Abdennebi, Manoj Chandra Garg, Fanghua Li
Engineering and Technology Journal
The use of membrane separation and heterogeneous photocatalysis together appears to be an innovative way to remove long-lasting pollutants such as paracetamol (PCT) from water. To overcome the limited process by understanding hindering the practical deployment of solar-driven photocatalytic membrane reactors (PMRs), this study proposes a process-engineering-centered framework for a low-cost, integrated ceramic PMR. A laboratory-scale system was developed using inexpensive red clay ceramic membranes modified by immobilizing TiO2 (P25) for paracetamol degradation under natural sunlight and ultraviolet irradiation. Unlike previous studies mainly focused on material development, this work evaluates the coupled effects of TiO2 loading, membrane inclination, …
Beyond Lipid-Lowering: Pleiotropic Effects Of Statins In Inflammation, Coagulation, And Cell Proliferation – Mechanisms And Clinical Implications, Kasidid Lawongsa, Yutthana Pansuwan, Supanut Kumjan
Beyond Lipid-Lowering: Pleiotropic Effects Of Statins In Inflammation, Coagulation, And Cell Proliferation – Mechanisms And Clinical Implications, Kasidid Lawongsa, Yutthana Pansuwan, Supanut Kumjan
Chulalongkorn Medical Journal
Statins are widely used lipid-lowering agents that significantly reduce cardiovascular morbidity and mortality through inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. Beyond their cholesterol-lowering properties, increasing evidence demonstrates that statins exert several pleiotropic effects independent of lipid reduction. These effects include anti-inflammatory, anti-thrombotic, and anti-proliferative actions mediated primarily through inhibition of the mevalonate pathway and downstream signaling molecules such as Rho, Rac, and Ras. Experimental and clinical studies have suggested potential benefits of statins in various non-cardiovascular conditions, including autoimmune diseases, venous thromboembolism, sepsis-associated coagulopathy, and certain malignancies. In addition, pharmacoepidemiologic studies have provided insights into the real-world effects and …
Evaluation Of Mdm2 Mrna Expression According To Clinicopathological Characteristics In Oral Squamous Cell Carcinoma (Oscc) Patients, Tirta Wardana
Evaluation Of Mdm2 Mrna Expression According To Clinicopathological Characteristics In Oral Squamous Cell Carcinoma (Oscc) Patients, Tirta Wardana
Chulalongkorn Medical Journal
Background: The murine double minute 2 (MDM2) gene encodes an E3 ubiquitin ligase that targets p53 for degradation, thereby influencing the pathogenesis of oral squamous cell carcinoma (OSCC).
Objective. The present study investigates MDM2 mRNA expression and its association with clinical and pathological characteristics in OSCC patients.
Methods: We conducted an observational-analytical study using a cross-sectional design. The study involved 39 OSCC patients. RNA extraction, cDNA synthesis, and quantitative PCR (qPCR) were performed. We quantified relative MDM2 mRNA expression using the Livak method (2-ΔΔCT) and GenEX MultiD software version 6.0. Statistical significance was assessed using independent t-tests.
Results: Although no …
Ameliorative Effect Of Ethanolic Extract Of Nardostachys Jatamansi Against High Fat Diet Induced Dyslipidemia In Rats, Umanath Preethi, Govindaraj Sumathy, Nathiya Shanmugam
Ameliorative Effect Of Ethanolic Extract Of Nardostachys Jatamansi Against High Fat Diet Induced Dyslipidemia In Rats, Umanath Preethi, Govindaraj Sumathy, Nathiya Shanmugam
Chulalongkorn Medical Journal
ABSTRACT:
Background and objective: The present study aimed to evaluate the antioxidant and hypolipidemic effects of ethanol extract of Nardostachys Jatamansi (N.J) in a high-fat diet-induced obesity model in male Wistar albino rats.Materials and methods:36 male Wistar albino rats were randomly divided into six groups, each comprising six animals: Group I received a normal diet for 9 weeks, while Group II was fed a high-fat diet (HFD) for the same period. Groups III–VI were also given HFD throughout. From week 5, Group III received rosuvastatin (10 mg/kg), and Groups IV–VI were treated with Nardostachys Jatamansi. extract at 100, 200, and …
Pneumoperitoneum As A Rare Complication Of Percutaneous Vertebroplasty: A Case Report, Chen-Ting Yang, I-Han Hsiao, Chun-Chung Chen, Der-Yang Cho, Hui-Shan Lu, Po-Fan Chiu
Pneumoperitoneum As A Rare Complication Of Percutaneous Vertebroplasty: A Case Report, Chen-Ting Yang, I-Han Hsiao, Chun-Chung Chen, Der-Yang Cho, Hui-Shan Lu, Po-Fan Chiu
BioMedicine
A 70-year-old woman with a history of hepatocellular carcinoma and bone metastasis underwent percutaneous vertebroplasty for multilevel pathological vertebral compression fractures due to back pain persisting despite conservative treatment. Subsequently, she reported significant pain relief; however, on postoperative day 1, she complained of intermittent, diffuse, and severe abdominal pain. Imaging examination revealed free air in the retroperitoneum and paraspinal space, suggesting hollow organ perforation. She refused exploratory surgery and was consequently discharged against medical advice with only oral antibiotics. Two weeks later, she returned for follow-up. She was in good condition with stable vital signs and no signs of toxic …
Design And Development Of Novel Peptidomimetic Compounds For Cancer Therapeutics: Focus On Hsp90–Cdc37 Interaction, Sarath Perumal, Ramanathan Karuppasamy
Design And Development Of Novel Peptidomimetic Compounds For Cancer Therapeutics: Focus On Hsp90–Cdc37 Interaction, Sarath Perumal, Ramanathan Karuppasamy
BioMedicine
Background: The HSP90 and CDC37 molecular chaperone complex governs the
stability and function of numerous client protein kinases, making it a crucial cancer target. Given their central role, disrupting this interaction induces proteotoxic stress and inhibits tumor progression. Therapeutic peptides are the mainstay of treatment for disruption of key interactions, yet they face limitations such as toxicity, resistance, and poor stability. Aim: This study aims to leverage peptidomimetics as novel disruptors of the HSP90–CDC37 interaction. Methods: Two peptides, a 9-mer and a 7-mer, were rationally designed by analyzing key regions facilitating HSP90–CDC37 complex formation. In silico mutational analysis identified …