Digital Commons Network^™

Maize Microrna166 Inactivation Confers Plant Development And Abiotic Stress Resistance, Na Li, Tianxiao Yang, Zhanyong Guo, Qiusheng Wang, Mao Chai, Mingbo Wu, Xiaoqi Li, Weiya Li, Guangxian Li, Jihua Tang, Guiliang Tang

Michigan Tech Publications, Part 1

MicroRNAs are important regulators in plant developmental processes and stress responses. In this study, we generated a series of maize STTM166 transgenic plants. Knock-down of miR166 resulted in various morphological changes, including rolled leaves, enhanced abiotic stress resistance, inferior yield-related traits, vascular pattern and epidermis structures, tassel architecture, as well as abscisic acid (ABA) level elevation and indole acetic acid (IAA) level reduction in maize. To profile miR166 regulated genes, we performed RNA-seq and qRT-PCR analysis. A total of 178 differentially expressed genes (DEGs) were identified, including 118 up-regulated and 60 down-regulated genes. These DEGs were strongly enriched in cell …

Contrast-Enhanced Ultrasound In Association With Serum Biomarkers For Differentiating Combined Hepatocellular-Cholangiocarcinoma From Hepatocellular Carcinoma And Intrahepatic Cholangiocarcinoma., Jie Yang, Ya-Han Zhang, Jia-Wu Li, Ying-Yu Shi, Jia-Yan Huang, Yan Luo, Ji-Bin Liu, Qiang Lu

Department of Radiology Faculty Papers

BACKGROUND: Combined hepatocellular-cholangiocarcinoma (CHC) is a rare type of primary liver cancer. Due to its complex histopathological characteristics, the imaging features of CHC can overlap with those of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC).

AIM: To investigate the possibility and efficacy of differentiating CHC from HCC and ICC by using contrast-enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI-RADS) and tumor biomarkers.

METHODS: Between January 2016 and December 2019, patients with histologically confirmed CHC, ICC and HCC with chronic liver disease were enrolled. The diagnostic formula for CHC was as follows: (1) LR-5 or LR-M with elevated alpha-fetoprotein …

Sybil Defense Using Efficient Resource Burning, Diksha Gupta

Computer Science ETDs

In 1993, Dwork and Naor proposed using computational puzzles, a resource burning mechanism, to combat spam email. In the ensuing three decades, resource burning has broadened to include communication capacity, computer memory, and human effort. It has become a well-established tool in distributed security. Due to the cost attached to utilizing resource burning mechanism, these have not been popularized in domains apart from cryptocurrency.

In this dissertation, we design efficient resource burning based Sybil defense techniques for permissionless systems. As a first step, we identify existing resource burning mechanisms in literature in Chapter 2. Additionally, we enumerate numerous open problems …

Analyses Of The 2020 Nobel Prize In Physiology Or Medicine: Taking The Hepatitis C Virus From Mystery Killer To Preventable And Treatable Disease, Neyda V. Gilman

Library Scholarship

Harvey J. Alter, Michael Houghton, and Charles M. Rice share the 2020 Nobel in Physiology or Medicine for their contributions to the identification, treatment, and eventual elimination of the hepatitis C virus (HCV). The then novel molecular techniques they used have laid the groundwork for future work on HCV and other viruses. This article will give a brief overview of the hepatitis disease and the work of this year's laureates. It will also take a bibliometric look at the scientist’s research and add to the discussions about the way modern science is done and the limitations of prestigious science awards …

The Use Of Concentrate Supplements To Overcome Seasonal Shortages Of Grazed Herbage In Beef Production Systems, Valéria P. B. Euclides, Kepler Euclides Filho, Fernando Paim Costa, Alexandre Scaff Raffia

IGC Proceedings (1977-2023)

No abstract provided.

Effects Of Novel Ryegrass Endophytes On Pasture Production And Milk Production From Dairy Cows In Northern New Zealand, Errol R. Thom, C. D. Waugh, E. M. K. Minneé, G. C. Waghorn, Alison J. Popay

IGC Proceedings (1977-2023)

No abstract provided.

The Cottonwood Ranch Riparian Management Case Study, Sherman Swanson, Kent Mcadoo, Agee Smith, Sandra Wyman

IGC Proceedings (1977-2023)

No abstract provided.

Print Culture, Digital Culture, Poetics And Hermeneutics: Discussion With J. Hillis Miller, Liyuan Zhu

CLCWeb: Comparative Literature and Culture

This paper is a response to Hillis Miller’s query on the author’s essay “Hillis Miller on the End of Literature.” The author basically agrees with Miller’s view on the shift from print culture to digital culture, explaining the special cultural context under which Chinese scholars emphasize the visual turn. Based on the rapid development of Chinese online literature, the author points out that print culture does not rival but coexists with digital culture. On the other hand, drawing on Aristotle’s Poetics and insights of several leading figures of contemporary hermeneutics, the author contends that Miller’s dichotomy of poetics (form) and …

Grazing Itineraries And Feed Intake Of Goats On Communal Pastures Of The Jabal Al Akhdar Mountain Range, Northern Oman, E. Schlecht, U. Dickhoefer, M. Predotova, Andreas Buerkert

IGC Proceedings (1977-2023)

No abstract provided.

Timing Of Grazing Affects Sandhills Grassland Productivity And Diet Quality, W. H. Schacht, J. D. Volesky, P. R. Schroeder

IGC Proceedings (1977-2023)

No abstract provided.

Ever Graze‐More Livestock From Perennials, Geoffrey Saul, Angela Avery

IGC Proceedings (1977-2023)

No abstract provided.

Operationalizing Niche Construction Theory With Stone Tools, Radu Lovita, David R. Braun, Matthew J. Douglass, Simon J. Holdaway, Sam C. Lin, Deborah I. Olsezewski, Zeljko Rezek

School of Natural Resources: Faculty Publications

One of the greatest difficulties with evolutionary approaches in the study of stone tools (lithics) has been finding a mechanism for tying culture and biology in a way that preserves human agency and operates at scales that are visible in the archaeological record. The concept of niche construction, whereby organisms actively construct their environments and change the conditions for selection, could provide a solution to this problem. In this review, we evaluate the utility of niche construction theory (NCT) for stone tool archaeology. We apply NCT to lithics both as part of the “extended phenotype” and as residuals or precipitates …

Dysregulated Interferon Response Underlying Severe Covid-19, Leann Lopez, Peter C. Sang, Yun Tian, Yongming Sang

Agricultural and Environmental Sciences Faculty Research

Innate immune interferons (IFNs), including type I and III IFNs, constitute critical antiviral mechanisms. Recent studies reveal that IFN dysregulation is key to determine COVID-19 pathogenesis. Effective IFN stimulation or prophylactic administration of IFNs at the early stage prior to severe COVID-19 may elicit an autonomous antiviral state, restrict the virus infection, and prevent COVID-19 progression. Inborn genetic flaws and autoreactive antibodies that block IFN response have been significantly associated with about 14% of patients with life-threatening COVID-19 pneumonia. In most severe COVID-19 patients without genetic errors in IFN-relevant gene loci, IFN dysregulation is progressively worsened and associated with the …

Southern Adventist University Commencement Program December 13, 2020, Southern Adventist University

Commencement Programs

Program for Southern Adventist University December graduation. The commencement service took place on December 13, 2020.

Toll-Like Receptor 7 Is Required For Lacrimal Gland Autoimmunity And Type 1 Diabetes Development In Male Nonobese Diabetic Mice., Ivy L Debreceni, Michael S Chimenti, David V. Serreze, Aron M Geurts, Yi-Guang Chen, Scott M Lieberman

Faculty Research 2020

Sjögren syndrome (SS) is an immunologically complex, chronic autoimmune disease targeting lacrimal and salivary glands. Nonobese diabetic (NOD) mice spontaneously develop inflammation of lacrimal and salivary glands with histopathological features similar to SS in humans including focal lymphocytic infiltrates in the affected glands. The innate immune signals driving lymphocytic infiltration of these glands are not well-defined. Here we evaluate the role of Toll-like receptor (TLR) 7 in the development of SS-like manifestations in NOD mice. We created a Tlr7 knockout NOD mouse strain and performed histological and gene expression studies to characterize the effects of TLR7 on autoimmunity development. TLR7 …

Possible Transmission Flow Of Sars-Cov-2 Based On Ace2 Features, Sk Sarif Hassan, Shinjini Ghosh, Diksha Attrish, Pabitra Pal Choudhury, Alaa A A Aljabali, Bruce D Uhal, Kenneth Lundstrom, Nima Rezaei, Vladimir N Uversky, Murat Seyran, Damiano Pizzol, Parise Adadi, Antonio Soares, Tarek Mohamed Abd El-Aziz, Ramesh Kandimalla, Murtaza M Tambuwala, Gajendra Kumar Azad, Samendra P Sherchan, Wagner Baetas-Da-Cruz, Kazuo Takayama, Ángel Serrano-Aroca, Gaurav Chauhan, Giorgio Palu, Adam M Brufsky

All publications

Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22-42, aa 79-84, and aa 330-393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the …

Giftedness In Young Children: What Do Parents And Teachers Know?, Katie Goodman

Departmental Honors & Graduate Capstone Projects

Abstract

Past research has explored how young children express giftedness as well as how parents and teachers can best meet the needs of these children once they have been identified. However, there is a distinct lack of literature on what parents and teachers actually know about how giftedness manifests in the youngest learners. This research investigates the background knowledge that teachers and parents of preschoolers hold on the notion of giftedness. Parents and teachers of young children were surveyed using online survey software by contacting a diverse set of private preschools within the Northern Virginia area. Parents and teachers at …

Pertumbuhan Dan Hasil Benih Kentang G0 Kultivar Medians Pada Berbagai Komposisi Media Tanam Dan Interval Pemberian Air Di Dataran Medium, Jajang Sauman Hamdani, Sumadi, Kusumiyati, Haifa Ruwaidah

Jurnal Kultivasi

Benih merupakan kunci sukses budidaya kentang. Salah satu faktor yang mempengaruhi dan menjadi kendala produksi kentang di Indonesia adalah ketersediaan benih kentang yang memiliki kualitas dan kuantitas baik serta belum memenuhi kebutuhan permintaan benih petani kentang. Permasalahan produksi benih kentang generasi ke-0 (G0) adalah rendahnya jumlah ubi benih yang dihasilkan. Percobaan ini bertujuan untuk mengetahui interaksi antara komposisi media tanam dengan interval pemberian air terhadap produksi benih kentang G0 di dataran medium. Percobaan dilaksanakan di Kebun Percobaan, Fakultas Pertanian, Universitas Padjadjaran, Kampus Jatinangor. Rancangan percobaan yang digunakan yaitu Split Plot. Petak utama adalah komposisi media tanam yang terdiri dari campuran …

St. Augustine Parish Sunday Bulletin, December 13, 2020

Saint Augustine Parish Sunday Bulletin

A newsletter published for Deaf Catholics in Cleveland, OH

Saint Augustine Parish Sunday Bulletin Finding Aid

Yap And Taz Maintain Prox1 Expression In The Developing Lymphatic And Lymphovenous Valves In Response To Vegf-C Signaling, Boksik Cha, Yen-Chun Ho, Xin Geng, Md Riaj Mahamud, Lijuan Chen, Yeunhee Kim, Dongwon Choi, Tae Hoon Kim, Gwendalyn J Randolph, Xinwei Cao, Hong Chen, R Sathish Srinivasan

Open Access Publications

Lymphatic vasculature is an integral part of digestive, immune and circulatory systems. The homeobox transcription factor PROX1 is necessary for the development of lymphatic vessels, lymphatic valves (LVs) and lymphovenous valves (LVVs). We and others previously reported a feedback loop between PROX1 and vascular endothelial growth factor-C (VEGF-C) signaling. PROX1 promotes the expression of the VEGF-C receptor VEGFR3 in lymphatic endothelial cells (LECs). In turn, VEGF-C signaling maintains PROX1 expression in LECs. However, the mechanisms of PROX1/VEGF-C feedback loop remain poorly understood. Whether VEGF-C signaling is necessary for LV and LVV development is also unknown. Here, we report for the …

Fifty Years Ago, My Grandfather Won The Nyc Marathon And Changed New York History, Colin M. Kern

Capstones

In 1970, my grandfather won the first New York City Marathon. This piece of long-form narrative journalism tells the story of how that race grew into the largest race in the world, which fosters New York City's colossal running community. The article is accompanied by photos, an animation that breaks down the original New York City Marathon course, and gif's that compare running footwear from the '70s and today.

The Fourth Wall Of Jericho: Wrestling With Covid, Cheyenne R. Ubiera

Capstones

COVID has affected everyone in the world in some shape or form. The Fourth Wall of Jericho hones in on independent wrestlers whose lives have been altered due to the virus — a rookie whose been down on his luck in kick-starting his career and frequent worker whose using the extra time in quarantine to get better at the craft.

The Fourth Wall of Jericho breaks the fourth wall of pro wrestling in an effort take a look a wrestler’s lives outside of the ring

Role Of Nutraceuticals In Covid-19 Mediated Liver Dysfunction, Mohammed Sikander, Shabnam Malik, Anyssa Rodriguez, Murali M. Yallapu, Acharan S. Narula, Sanjaya K. Satapathy, Vijian Dhevan, Subhash C. Chauhan, Meena Jaggi

School of Medicine Publications

COVID-19 is known as one of the deadliest pandemics of the century. The rapid spread of this deadly virus at incredible speed has stunned the planet and poses a challenge to global scientific and medical communities. Patients with COVID-19 are at an increased risk of co-morbidities associated with liver dysfunction and injury. Moreover, hepatotoxicity induced by antiviral therapy is gaining importance and is an area of great concern. Currently, alternatives therapies are being sought to mitigate hepatic damage, and there has been growing interest in the research on bioactive phytochemical agents (nutraceuticals) due to their versatility in health benefits reported …

The Feeding Scheme Of Extensive Animal Production Systems In Montado, José Mira Potes

IGC Proceedings (1977-2023)

No abstract provided.

Stirling Cycle Machine Analysis, Israel Urieli

OHIO Open Faculty Textbooks

Dedicated to William T. Beale (1928 - 2016), inventor of the Free Piston Stirling Engine, Mentor and Frien.

This web resource is intended to be totally self contained learning resource for the analysis and development of computer simulation of single phase, piston/cylinder Stirling cycle machines. It includes thermodynamic, heat transfer and fluid flow friction analysis, and until 2012 it was used as resource material for an advanced course for Mechanical Engineering majors. The course structure was based on the book by I.Urieli & D.M.Berchowitz 'Stirling Cycle Engine Analysis' (Adam Hilger, 1984). The computer simulation program modules (originally written in FORTRAN) …

The Clean Air Act: How It Can Be Localized To Promote Both Environmental And Social Justice, Tate Kirk

Seattle Journal of Technology, Environmental, & Innovation Law

Legislators attempt to achieve intended goals by enacting laws that provide for regulatory enforcement. However, many times laws are unable to achieve their stated goals and in some ways may create new or exacerbate existing issues. Luckily, upon review, many of these issues can be fixed with quick modifications to either their implementation or enforcement mechanisms. In its current form, the Clean Air Act does not effectively account for differences in regional climate patterns, and, moreover, it perpetuates environmental injustice. If local governments were given more autonomy to enforce the Clean Air Act, they could shape its enforcement to more …

Wildlife Trade And Covid-19: Towards A Criminology Of Anthropogenic Pathogen Spillover, Piers Beirne Phd

Department of Criminology

The general remit of this paper is the role of wildlife trade in pathogen spillover. Its underlying assumption is that, so far from being the exclusive domain of the life sciences, the study of pathogen spillover will be greatly enhanced by multi-perspectival approaches, including One Health and those employed here, namely, non-speciesist green criminology and critical animal studies. The paper moves from discussions of zoonosis, anthroponosis and wildlife trade to the emergence of COVID-19 in Wuhan, China. The paper recommends the abolition of all wildlife trade and the reclamation of wildlife habitat and broaches discussion of the extension of legal …

Assessing Moringa Oleifera Plants As Exposure Pathways For Heavy Metals In Highly Contaminated Areas, Marissa Louise Mayfield*

Biology Theses

This study examined the uptake of heavy metals by Moringa oleifera trees in both field and laboratory settings. The main goal of this study was to determine whether using Moringa, grown in heavily contaminated areas, as food or herbal supplements increases the risk of heavy metal exposure. The field component of this study was carried out in the Southern part of Kabwe, Zambia where a lead-zinc mine has left a legacy of severe environmental pollution in the neighboring areas. Moringa trees have several medicinal properties which is one of the reasons they were first introduced to the area. The trees …

An Invasive Species As A Threat To Native Biodiversity: Larval Competition Between Native Anurans And An Invasive Treefrog, Mckenzie Wasley

Electronic Theses and Dissertations

Cuban Treefrogs (Osteopilus septentrionalis) are established in Florida and Louisiana and have invasive potential further westward, possibly impacting native anurans at multiple life stages. In anurans, competition at the larval stage can decrease adult fitness through slower development and smaller size at metamorphosis, ultimately decreasing recruitment rates. To examine the potential impacts of O. septentrionalis at the larval life-history stage, I quantified activity levels and growth of their tadpoles and those of two anurans native to eastern Texas: Green Treefrogs (Hyla cinerea) and Gulf Coast Toads (Incilius nebulifer). Tadpoles of the three species were …

Prenatal Alcohol Exposure Alters Transcriptional Expression Of Stress And Tlr4-Related Immune Signaling Factors In The Brain Following Early Life Stress, Chaselyn D. Ruffaner-Hanson

Biomedical Sciences ETDs

Background: Depression and anxiety disorders, believed to be caused by stress-related neuropeptides and pro-inflammatory molecules in the brain, are prevalent comorbidities of fetal alcohol spectrum disorders (FASD).

Methods: Brain tissue was collected following a 4-hour maternal separation stress during the early postnatal period, postnatal days 10 and 12, from mice subjected to 1^st and 2^nd trimester prenatal alcohol exposure (PAE).

Hypothesis: We hypothesized that PAE leads to glucocorticoid receptor insensitivity, stress molecule overexpression, and potentiated toll-like receptor 4 (TLR4) pathway inflammatory responses in the brain following early life stress.

Results: PAE and stress increased mRNA expression of TLR4 …