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2020

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A Combinatorial Strategy For Overcoming Primary And Acquired Resistance Of Mek Inhibition In Colorectal Cancer, Junjun Chen, Jie Dai, Zhiming Kang, Ting Yang, Qi Zhao, Jinxiu Zheng, Xinxin Zhang, Jisheng Zhang, Jun Xu, Gongqin Sun, Lijun Yang, Tao Yang Aug 2020

A Combinatorial Strategy For Overcoming Primary And Acquired Resistance Of Mek Inhibition In Colorectal Cancer, Junjun Chen, Jie Dai, Zhiming Kang, Ting Yang, Qi Zhao, Jinxiu Zheng, Xinxin Zhang, Jisheng Zhang, Jun Xu, Gongqin Sun, Lijun Yang, Tao Yang

Cell and Molecular Biology Faculty Publications

Compared with traditional chemotherapeutic drugs, targeted therapeutic medicine has the advantages of high efficacy and less toxic side effects. However, in clinical practice for treatment of colorectal cancer, the primary and acquired resistance of these medicines limits their effectiveness in targeted therapy, therefore impedes the development of precision medicine and personalized therapy. Currently, there are limited number of drugs for targeted therapy of colorectal cancer, mainly monoclonal antibodies against EGFR or VEGFR inhibitors. Trametinib, a MEK inhibitor, has been applied in melanoma patient successfully, but not been used in clinical treatment of colorectal cancer because of its drug resistance. To …

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Animal Science E-Newsletter, August 2020, University Of Arkansas, Fayetteville. Department Of Animal Sciences Aug 2020

Animal Science E-Newsletter, August 2020, University Of Arkansas, Fayetteville. Department Of Animal Sciences

Animal Science e-Newsletter

No abstract provided.

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A Comparative Study Of The Production And Treatment Of Wooden And Paper Bookboards To Inform The Treatment Of Two Books, Oa Sjoblom Aug 2020

A Comparative Study Of The Production And Treatment Of Wooden And Paper Bookboards To Inform The Treatment Of Two Books, Oa Sjoblom

Art Conservation Master's Projects

The production and treatment of wooden and paper book boards was explored through research and treatment of two bindings: the Strasbourg Bible from 1734, a binding with wooden boards with a split front board; and Peter B. Porter’s letterbook from 1814, a binding with paper boards with losses and weakening of the board. Primary sources such as bookbinding and boardmaking manuals were reviewed to understand the production of the two types of boards. To guide treatment, a literature review of historic and recent relevant conservation treatments was conducted. The board treatments performed were guided by this research, and focused of …

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Biomarker Application For Precision Medicine In Stroke, Alexis N. Simpkins, Miroslaw Janowski, Helieh S. Oz, Jill Roberts, Gregory Bix, Sylvain Doré, Ann M. Stowe Aug 2020

Biomarker Application For Precision Medicine In Stroke, Alexis N. Simpkins, Miroslaw Janowski, Helieh S. Oz, Jill Roberts, Gregory Bix, Sylvain Doré, Ann M. Stowe

Neurosurgery Faculty Publications

Stroke remains one of the leading causes of long-term disability and mortality despite recent advances in acute thrombolytic therapies. In fact, the global lifetime risk of stroke in adults over the age of 25 is approximately 25%, with 24.9 million cases of ischemic stroke and 18.7 million cases of hemorrhagic stroke reported in 2015. One of the main challenges in developing effective new acute therapeutics and enhanced long-term interventions for stroke recovery is the heterogeneity of stroke, including etiology, comorbidities, and lifestyle factors that uniquely affect each individual stroke survivor. In this comprehensive review, we propose that future biomarker studies …

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Point Pattern Analysis, Barry N. Boots, Arthur Getls Aug 2020

Point Pattern Analysis, Barry N. Boots, Arthur Getls

Web Book of Regional Science

Points on a map can represent many important phenomena, including towns, stores and centers for shopping, industrial locations, parks, archaeological sites, plant and animal species, the home site of a person with a possible environmentally related disease, and so on. The authors introduce readers to the general analysis of the location of points on maps. Map patterns are assumed to result from one or more spatial processes in the human or physical world. Often the causal forces are known, but more frequently, researchers seek to identify them. The analysis of the spatial pattern of the phenomena under study can be …

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The Evolution Of Life Histories And Phenotypic Plasticity Across Environmental Gradients In Daphnia Sp., Michelle Renee Swan Packer Aug 2020

The Evolution Of Life Histories And Phenotypic Plasticity Across Environmental Gradients In Daphnia Sp., Michelle Renee Swan Packer

Biology Dissertations - Archive

Understanding how environmentally-induced variation ultimately leads to speciation is a main component of evolutionary ecology. This dissertation uses Daphnia in experimental and comparative studies to address several theoretical questions concerning the role of phenotypic plasticity in the evolutionary process. Specifically, I explore novel environmental factors which induce plasticity and investigate the plastic response across systems to determine general hypotheses for understanding the mechanisms which may be involved. Additionally, this dissertation provides empirical results which add to the body of research investigating the transition between environmentally induced phenotypes and genetic adaptation. The results of this body of work show that ancestral …

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Development Of Reductive/Oxidative Treatment Strategy For The Removal Of Per- And Polyfluoroalkyl Substances (Pfas) In Water, Akshay Parenky Aug 2020

Development Of Reductive/Oxidative Treatment Strategy For The Removal Of Per- And Polyfluoroalkyl Substances (Pfas) In Water, Akshay Parenky

Civil Engineering Dissertations - Archive

The detrimental health effects of halogenated compounds in humans has been well documented, and the frequent occurrence of per- and polyfluoroalkyl substances (PFAS) in the water environment is a recent global concern. Feasible and sensible treatment strategies are in dire need for environmental remediation and water treatment. Currently, efficient treatment is only obtained at a small scale and at a high energy cost. This research is presented in three subsections, where decomposition of selected PFAS was evaluated under advanced oxidation techniques. The first study involved decomposition of a polyfluoroalkyl substance, 6:2 fluorotelomer sulfonate (6:2 FTS), in which 2 carbons of …

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Variability And Temporal Trends Of Semivolatile Organic Compounds In Biological And Environmental Media, Kyunghoon Kim Aug 2020

Variability And Temporal Trends Of Semivolatile Organic Compounds In Biological And Environmental Media, Kyunghoon Kim

Earth & Environmental Sciences Dissertations - Archive

Exposure to semivolatile organic compounds (SVOCs) in indoor environments and its potential impact on human health have been receiving increased public attention, because people in developed countries spend over 80% of their time indoors, SVOC levels are several orders of magnitude higher indoors than outdoors, and many SVOCs have various toxicities and endocrine disrupting potential. Concentrations of SVOCs in biological (e.g., human serum) and environmental (e.g., household dust, indoor air) media can help us better understand human exposure to SVOCs. For example, SVOC concentrations in biological media collected over several years may shed light on temporal trends of exposure due …

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A Ph Sensor For Non-Invasive Detection And Monitoring Of Ph Changes During Implant-Associated Infection Using X-Ray Excited Luminescence Chemical Imaging, Unaiza Uzair Aug 2020

A Ph Sensor For Non-Invasive Detection And Monitoring Of Ph Changes During Implant-Associated Infection Using X-Ray Excited Luminescence Chemical Imaging, Unaiza Uzair

All Dissertations

Implant-associated infection is a leading cause of fixation failures and these infections are resistant to antibiotics especially after mature biofilms have been established on the implant surface. These infections can also be challenging to detect, especially at early stages or during antibiotic treatment, due to lack of symptoms and specific tests to detect localized infection. Low pH is believed to be associated with infection as bacteria and inflammatory responses can cause a pH drop in the affected area. Detecting changes in pH on the implant surface can provide a better understanding and help to detect, treat and monitor such infections …

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Information Technology Services Fy2020 - Winona State University, Minnesota, Information Technology Services-Winona State University Aug 2020

Information Technology Services Fy2020 - Winona State University, Minnesota, Information Technology Services-Winona State University

Information Technology Services Annual Reports

Information Technology Services (ITS) provides the technology-based foundation to support and empower the Winona State University (WSU) community to meet and exceed their educational and business needs. This is the ITS report for the fiscal year 2020 (July 1, 2019-June 30, 2020).

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Alcohol Ablation Of Cardiac Tissues Quantified And Evaluated Using Cielab Euclidean Distances, Ashley Rook, Mathews M John, Allison Post, Mehdi Razavi Aug 2020

Alcohol Ablation Of Cardiac Tissues Quantified And Evaluated Using Cielab Euclidean Distances, Ashley Rook, Mathews M John, Allison Post, Mehdi Razavi

The Texas Heart Institute Journal

Ethanol solubilizes cell membranes, making it useful for various ablation applications. We examined the effect of time and alcohol type on the extent of ablation, quantified as Euclidean distances between color coordinates. We obtained biopsy punch samples (diameter, 6 mm) of left atrial appendage, atrial, ventricular, and septal tissue from porcine hearts and placed them in transwell plates filled with ethanol or methanol for 10, 20, 30, 40, 50, or 60 min. Control samples were taken for each time point. At each time point, samples were collected, cut transversely, and photographed. With use of a custom MATLAB program, all images …

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Data For "Consistent Differences In A Virtual World Model Of Ape Societies", Bart J. Wilson, Sarah F. Brosnan, Elizabeth V. Lonsdorf, Crickette M. Sanz Aug 2020

Data For "Consistent Differences In A Virtual World Model Of Ape Societies", Bart J. Wilson, Sarah F. Brosnan, Elizabeth V. Lonsdorf, Crickette M. Sanz

Business and Economics Faculty Data Sets

The zip file contains the data for the paper entitled "Consistent Differences in a Virtual World Model of Ape Societies" which appears in Scientific Reports.

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The Property Species: Mine, Yours, And The Human Mind, Bart J. Wilson Aug 2020

The Property Species: Mine, Yours, And The Human Mind, Bart J. Wilson

Economics Faculty Books and Book Chapters

"Arguing that neither the sciences nor the humanities synthesizes a full account of property, the book offers a cross-disciplinary compromise that is sure to be controversial: Property is a universal and uniquely human custom. Integrating cognitive linguistics with philosophy of property and a fresh look at property disputes in the common law, the book makes the case that symbolic-thinking humans locate the meaning of property within a thing. That is, all human beings and only human beings have property in things, and at its core, property rests on custom, not rights. Such an alternative to conventional thinking contends that the …

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Crease: Synchronous Gait By Minimizing Actuation Through Folded Geometry, Olga Mesa, Saurabh Mhatre, Dan Aukes Aug 2020

Crease: Synchronous Gait By Minimizing Actuation Through Folded Geometry, Olga Mesa, Saurabh Mhatre, Dan Aukes

Architecture, Art, and Historic Preservation Faculty Publications

The Age of the Fourth Industrial Revolution promises the integration and synergy of disciplines to arrive at meaningful and comprehensive solutions. As computation and fabrication methods become pervasive, they present platforms for communication. Value exists in diverse disciplines bringing their approach to a common conversation, proposing demands, and potentials in response to entrenched challenges. Robotics has expanded recently as computational analysis, and digital fabrication methods are more accurate and reliable. Advances in functional microelectromechanical components have resulted in the design of new robots presenting alternatives to traditional ambulatory robots. However, most examples are the result of intense computational analysis necessitating …

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Minimum Reporting Guidelines And The Role Of Causal Inference In Functional Neuroimaging For Obesity Research, Tyler Davis, Hans Rudolf Berthoud, Martin Binks Aug 2020

Minimum Reporting Guidelines And The Role Of Causal Inference In Functional Neuroimaging For Obesity Research, Tyler Davis, Hans Rudolf Berthoud, Martin Binks

Division of Basic Science Faculty Publications

No abstract provided.

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Reproductive Health In The Philippines: Poverty, Religiosity, And Navigating Reproductive Choices, Allison Goncena Aug 2020

Reproductive Health In The Philippines: Poverty, Religiosity, And Navigating Reproductive Choices, Allison Goncena

International Studies (MA) Theses

This dissertation centers the Philippines as a case study in which quantitative and qualitative data from empirical studies, science journal articles, social science texts, and interviews are cross-examined to ascertain two main areas of interest. The first incentive is to identify and analyze the Catholic Church’s resources in perpetuating moral male-dominant rhetoric that have delayed efforts supporting reproductive health intended to aid low-income women concerning their sexual and reproductive health. The second incentive is to detect how low-income women’s thoughts and behaviors in making reproductive decisions are resonant or not of the Church’s moral rectitude over SRH through their demonstrations …

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The Investigation Of Group 1 Late Embryogenesis Abundant Protein 6 And Its Role In Arabidopsis Thaliana Desiccation Tolerance, Joann Eise Thomson Aug 2020

The Investigation Of Group 1 Late Embryogenesis Abundant Protein 6 And Its Role In Arabidopsis Thaliana Desiccation Tolerance, Joann Eise Thomson

Masters Theses

Like most seeds, Arabidopsis thaliana seed development is divided into three major phases: morphogenesis, storage deposition, and maturation drying. During maturation drying the seed becomes desiccation tolerant (DT) at some point and the seed rapidly loses water until its moisture level is approximately 10% on a fresh weight basis. The ability of the seeds to withstand this extreme water loss is hypothesized to be due, in part, to the accumulation of late embryogenesis abundant (LEA) proteins. In A. thaliana, there are 51 LEA proteins which are divided into seven groups based on amino acid sequence similarities. Group 1 LEA …

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Bloom Or Bust: Search For Phytoplankton Community Drivers Using Long-Term Time-Series Observations And Field Measurements In A Model Great Lakes Estuary, Jasmine Mancuso Aug 2020

Bloom Or Bust: Search For Phytoplankton Community Drivers Using Long-Term Time-Series Observations And Field Measurements In A Model Great Lakes Estuary, Jasmine Mancuso

Masters Theses

As sentinels of climate change and other anthropogenic effects, freshwater lakes are experiencing ecosystem disruptions at every level of the food web, beginning with the phytoplankton. One of the major threats to waterbodies around the world are cyanobacterial harmful algal blooms (HABs) resulting from anthropogenic eutrophication and exacerbated by climate change. Muskegon Lake, a drowned river mouth Great Lakes estuary on the east coast of Lake Michigan, is no exception and was declared an Area of Concern by the EPA in 1987 with nuisance algal blooms cited as a beneficial use impairment. Using long-term data and additional 2019 sampling, we …

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13 Going On 30: An Exploration Of Expanding Coppa’S Privacy Protections To Everyone, Ariel Fox Johnson Aug 2020

13 Going On 30: An Exploration Of Expanding Coppa’S Privacy Protections To Everyone, Ariel Fox Johnson

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

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To Stop Sharenting & Other Children’S Privacy Harms, Start Playing: A Blueprint For A New Protecting The Private Lives Of Adolescents And Youth (Pplay) Act, Leah Plunkett Aug 2020

To Stop Sharenting & Other Children’S Privacy Harms, Start Playing: A Blueprint For A New Protecting The Private Lives Of Adolescents And Youth (Pplay) Act, Leah Plunkett

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

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The "Directive" Prong: Adding To The Allied-Signal Framework For Remand Without Vacatur, T. Alex B. Folkerth Aug 2020

The "Directive" Prong: Adding To The Allied-Signal Framework For Remand Without Vacatur, T. Alex B. Folkerth

Michigan Journal of Environmental & Administrative Law

“Remand without vacatur” is an administrative law remedy that allows courts reviewing agency actions with minor legal defects to leave the action in place while the agency fixes the defect. Courts use a two-prong test from the 1993 D.C. Circuit case Allied-Signal, Inc. v. U.S. Nuclear Regulatory Commission to determine whether or not to vacate the action pending remand. Allied-Signal’s “deficiency” prong directs the court to consider how bad the defect is. The “disruption” prong directs the court to consider how much havoc will be wreaked by the vacation of the action while the agency is fixing the defect. …

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What Determines Parasite Species Richness Across Host Species?, Tad Dallas, Lauren A. Holian, Grant Foster Aug 2020

What Determines Parasite Species Richness Across Host Species?, Tad Dallas, Lauren A. Holian, Grant Foster

Faculty Publications

© 2020 British Ecological Society In Focus: Dáttilo, W., Barrozo-Chávez, N., Lira-Noriega, A., Guevara, R., Villalobos, F., Santiago-Alarcon, D., Neves, F. S., Izzo, T., & Ribeiro, S. P. (2020). Species-level drivers of mammalian ectoparasite faunas. Journal of Animal Ecology. https://doi.org/10.1111/1365-2656.13216. The question of what drives the number of parasite species able to infect a given host species is still a largely open question, despite decades of research. Dáttilo and colleagues examine the potential drivers of ectoparasite species across a large set of host species to explore the taxonomic and trait drivers of host-parasite interactions. Here, we contextualize their findings, explore …

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3-D Printed Customizable Vitrification Devices For Preservation Of Genetic Resources Of Aquatic Species, Connor J. Tiersch, Yue Liu, Terrence R. Tiersch, William T. Monroe Aug 2020

3-D Printed Customizable Vitrification Devices For Preservation Of Genetic Resources Of Aquatic Species, Connor J. Tiersch, Yue Liu, Terrence R. Tiersch, William T. Monroe

Faculty Publications

Sperm vitrification as an alternative approach to conventional cryopreservation (equilibrium freezing) allows quick and low-cost sample preservation and is suitable for small-bodied aquatic species with miniscule testis, fieldwork at remote locations, and small-scale freezing for research purposes. The goal of this present study was to develop operational prototypes of 3-dimensional (3-D) printed vitrification devices with innovative components that can provide comprehensive functionalities for practical repository development for aquatic species. The design featured an elongated loop to suspend a thin film of sperm sample in cryoprotectant, a retractable sleeve to protect the vitrified samples and allow permanent labeling, a handle to …

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Adaptive Fat Oxidation Is Coupled With Increased Lipid Storage In Adipose Tissue Of Female Mice Fed High Dietary Fat And Sucrose, Scott Fuller, Yongmei Yu, Timothy D. Allerton, Tamra Mendoza, David M. Ribnicky, Z. Elizabeth Floyd Aug 2020

Adaptive Fat Oxidation Is Coupled With Increased Lipid Storage In Adipose Tissue Of Female Mice Fed High Dietary Fat And Sucrose, Scott Fuller, Yongmei Yu, Timothy D. Allerton, Tamra Mendoza, David M. Ribnicky, Z. Elizabeth Floyd

Division of Basic Science Faculty Publications

Western diets high in fat and sucrose are associated with metabolic syndrome (MetS). Although the prevalence of MetS in women is comparable to that in men, metabolic adaptations in females to Western diet have not been reported in preclinical studies. This study investigates the effects of Western diet on risk factors for MetS in female mice. Based on our earlier studies in male mice, we hypothesized that dietary supplementation with extracts of Artemisia dracunculus L. (PMI5011) and Momordica charantia (bitter melon) could affect MetS risk factors in females. Eight-week-old female mice were fed a 10% kcal fat, 17% kcal sucrose …

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Birds In Fragmented Amazonian Rainforest: Lessons From 40 Years At The Biological Dynamics Of Forest Fragments Project, Philip C. Stouffer Aug 2020

Birds In Fragmented Amazonian Rainforest: Lessons From 40 Years At The Biological Dynamics Of Forest Fragments Project, Philip C. Stouffer

Faculty Publications

For decades, ecologists have studied fundamental questions of how Amazonian biodiversity is maintained, and whether that diversity can persist following deforestation. The long history of avian research at the Biological Dynamics of Forest Fragments Project, near Manaus, Brazil, has helped advance this understanding in the context of a broader research program focused on rainforest fragments embedded in a dynamic matrix. By sampling birds beginning before fragments were isolated, in the late 1970s, and continuing the protocol to the present, our work has revealed community dynamics driven not just by area and isolation, but also by larger landscape patterns, particularly second …

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Temporal And Concentration Effects Of Methanol On Cryopreservation Of Zebrafish (Danio Rerio) Sperm, Huiping Yang, E. Hu, Terrence Tiersch, Carrie Carmichael, Jen Matthews, Zoltan M. Varga Aug 2020

Temporal And Concentration Effects Of Methanol On Cryopreservation Of Zebrafish (Danio Rerio) Sperm, Huiping Yang, E. Hu, Terrence Tiersch, Carrie Carmichael, Jen Matthews, Zoltan M. Varga

Faculty Publications

We evaluated the cryoprotective effects of methanol on zebrafish sperm at different concentrations, exposure times, and stages during cryopreservation. Samples were collected by crushing of dissected testes or abdominal stripping. After exposure to 0%, 2%, 5%, 8%, and 10% methanol for 0-11 min, fresh sperm (1 × 106 cells/mL) did not show changes in plasma membrane integrity (measured by flow cytometer), but cell size changes (light scatter) were observed after exposure to 8% or 10%. After exposure for 0-60 min, fresh sperm (1 × 108 cells/mL) did not show significant changes in survival or membrane integrity. Sperm cryopreserved in 5%, …

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Changes In Body Weight, Adherence, And Appetite During 2 Years Of Calorie Restriction: The Calerie 2 Randomized Clinical Trial, James L. Dorling, Sai Krupa Das, Susan B. Racette, John W. Apolzan, Dachuan Zhang, Carl F. Pieper, Corby K. Martin Aug 2020

Changes In Body Weight, Adherence, And Appetite During 2 Years Of Calorie Restriction: The Calerie 2 Randomized Clinical Trial, James L. Dorling, Sai Krupa Das, Susan B. Racette, John W. Apolzan, Dachuan Zhang, Carl F. Pieper, Corby K. Martin

Clinical Research Faculty Publications

Background/objectives: The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy Phase 2 (CALERIE) study showed that individuals who are nonobese were able to undergo significant calorie restriction (CR), yet the time course changes in adherence, weight, and appetite are unknown. This analysis aimed to investigate the time course changes in adherence, body weight, and appetite during the CALERIE study. Subjects/methods: Overall, 143 participants (body mass index: 21.9–28.0 kg/m2) were randomized to a CR group that aimed to achieve 25% CR for 2 years. Throughout the intervention, body weight was measured, and appetite was assessed through visual analogue scales. …

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Using Public Databases For Genomic Prediction Of Tropical Maize Lines, Pedro Patric Pinho Morais, Deniz Akdemir, Luciano Rogério Braatz De Andrade, Jean Luc Jannink, Roberto Fritsche-Neto, Aluízio Borém, Filipe Couto Alves, Danilo Hottis Lyra, Ítalo Stefanine Correia Granato Aug 2020

Using Public Databases For Genomic Prediction Of Tropical Maize Lines, Pedro Patric Pinho Morais, Deniz Akdemir, Luciano Rogério Braatz De Andrade, Jean Luc Jannink, Roberto Fritsche-Neto, Aluízio Borém, Filipe Couto Alves, Danilo Hottis Lyra, Ítalo Stefanine Correia Granato

Faculty Publications

In this paper, the aims were (a) to test the usefulness of using genomic and phenotypic information from public databases (open access) to predict genetic values for tropical maize inbred lines regarding plant and ear height; (b) to identify how the population structure, the use of optimized training sets (OTSs) and the amount of information originating from public databases affect the predictive ability. Thus, 29 training sets (TSs) were defined considering three diversity panels: the University of São Paulo (USP—validation set (VS)) and the ASSO and USDA North Central Regional Plant Introduction Station (NCRPIS) (external public panels—predictors), which were divided …

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Writing About The Self In The World Aug 2020

Writing About The Self In The World

In Case You Missed It

AUGUST 2020

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Seasonal Distribution Of Microbial Biomass Carbon And Some Heavy Metals Around The Industrial Area Of Kano Metropolis, Northwestern-Nigeria, Mansur Abdul Mohammed, Luka Fitto Buba Aug 2020

Seasonal Distribution Of Microbial Biomass Carbon And Some Heavy Metals Around The Industrial Area Of Kano Metropolis, Northwestern-Nigeria, Mansur Abdul Mohammed, Luka Fitto Buba

Jurnal Geografi Lingkungan Tropik (Journal of Geography of Tropical Environments)

The accumulation of toxic heavy metals in excessive quantities has a detrimental effect on soil quality which interferes with key biochemical processes in soils. It is very imperative to explore soil microbial activities concerning to environmental conditions for sustainable soil management. The study aimed to assess the seasonal distribution of soil microbial biomass carbon (MBC), some heavy metals and pH, and their relationship in the soil ecosystem. Field investigation and laboratory analysis were the main methods adopted as sources of generating data and analyses. Ten soil samples were collected using composite sampling techniques on seasonal bases and then analyzed in …

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