Digital Commons Network^™

The Role Of Simulation In Urban Design Decisions: Microclimate And Human Comfort Considerations In Planning, Ingy El-Darwish, Amany Ragheb, Ahmed Sherif

Architecture and Planning Journal (APJ)

This paper reviews the usage of simulation tools that can evaluate outdoor thermal comfort and to predict outdoor environmental conditions with specific focus on decision making. The literature also highlights on the use of simulation as a tool in the field of urban design and the microclimatic enhancement approaches. Finally, the paper discusses the moderation of the built environment’s components on the climate with the aim for optimizing the thermal comfort level in outdoor urban space (Setaih K. et al., 2013). The aim of the paper is to highlight on the importance of simulation methods that can influence urban space …

A Criterion For Measuring Urban Intelligence, Yasser Fouda, Maged Zagow

Architecture and Planning Journal (APJ)

The emergence of complicated problems encountering the urban environment, like absence of sustainability, has led to the initiation of the notion called "Intelligent Urban Conglomerations". It aimed to maintain a minimal level of balance between features of the urban environment, through clinging to more prudent actions towards urban policies, like increasing awareness of healthy environment, energy, mobility organization, and other issues. A great and persisting need has emerged for a practical scientific evaluation means for urban plans in all of their technical phases. The research aims to advance a practical methodology for monitoring and evaluating urban projects, throughout designing, implementation, …

Improving The Design Quality Of Housing Buildings, Ehab Nasr Elden Ahmed

Architecture and Planning Journal (APJ)

Design quality is essential to improve the standards of living and is progressively being accepted as critical to successful new housing developments. A better design quality provides attractive and sensitively planned homes that form communities, and assists in creating a healthier and advanced fellowship. As new housing growth in Egypt has missed reaching the universal rules and guidelines of design quality, this research reviews several experiences of foreign offices and governmental programs that deal with amending the design character of housing buildings. Using these Guidelines enables commissioning high performance housing facilities that improve the general standards of a better design …

Rereading Albert Camus’ The Plague During A Pandemic: An African’S Review, Stephen O. Owino

The Journal of Social Encounters

No abstract provided.

Scented Multi-Layered Finishes For Metal Substrates, Joerg Hoehne

Defensive Publications Series

Described herein are coating systems for preparing scented multi-layered finishes, scented multi-layered finish-coated substrates, and methods of applying scented multi-layered finishes to metal substrates. A coating system for preparing scented multi-layered finishes includes a base coating component and a clear coating component comprising at least one fragrance. An additional coating system for preparing scented multi-layered finishes includes a base coating component, a printed coating component, and a clear coating component comprising at least one fragrance.

Herb Mayer Interviewed By Irene Burgess And Bruce Gentry, Herb Mayer, Irene Burgess, Bruce Gentry, Stephanie Opperman

Collecting the Past

In this week’s special episode, Irene Burgess and Bruce Gentry interview Herb Mayer.

Contextual Note: Prior to this conversation, Herb Mayer attended a virtual discussion between Dr. Angela Alaimo O’Donnell and Fr. Mark Bosco about O’Donnell’s recently released book, Radical Ambivalence: Race in Flannery O’Connor, so there are frequent references to her work

Npc1 Deficiency Impairs Cerebellar Postnatal Development Of Microglia And Climbing Fiber Refinement In A Mouse Model Of Niemann-Pick Disease Type C., Bridget R Boyle, Sierra E Melli, Ruth S Altreche, Zachary M Padron, Fawad A K Yousufzai, Sarah Kim, Mariella D Vasquez, Dawn M Carone, Benjamin Carone, Ileana Soto Reyes

College of Science & Mathematics Departmental Research

Little is known about the effects of NPC1 deficiency in brain development and whether these effects contribute to neurodegeneration in Niemann-Pick disease type C (NPC). Degeneration of cerebellar Purkinje cells occurs at an earlier stage and to a greater extent in NPC; therefore, we analyzed the effect of NPC1 deficiency on microglia and on climbing fiber synaptic refinement during cerebellar postnatal development using the

Four Works For Trumpet: Compositions By: Torelli, La Barbera, Ewazen And Hovhaness, Charles Meggitt

Recital Papers

The works included in this recital paper are presented as a program of music that delves into the expressive range of the trumpet as a solo instrument, and its uses by composers of differing time periods and artistic directions. The composers of this program were deliberately selected for their extreme sensibilities and knowledge of the uses of trumpet as a solo instrument. In this paper works by Giuseppe Torelli, John La Barbera, Eric Ewazen and Alan Hovhaness are explored to benefit performers and audience members through an exposure to both standard and unique selections of the repertoire.

Using Climate To Explain And Predict West Nile Virus Risk In Nebraska, Kelly Helm Smith, Andrew J. Tyre, Jeff Hamik, Michael J. Hayes, Yuzhen Zhou, Li Dai

National Drought Mitigation Center: Faculty Publications

We used monthly precipitation and temperature data to give early warning of years with higher West Nile Virus (WNV) risk in Nebraska. We used generalized additive models with a negative binomial distribution and smoothing curves to identify combinations of extremes and timing that had the most influence, experimenting with all combinations of temperature and drought data, lagged by 12, 18, 24, 30, and 36 months. We fit models on data from 2002 through 2011, used Akaike's Information Criterion (AIC) to select the best‐fitting model, and used 2012 as out‐of‐sample data for prediction, and repeated this process for each successive year, …

Intelligent Combination Of Discrete Lod Model For 3d Visualization Based On Visual Perception And Information Entropy Fusion, Che Li, Fengju Kang

Journal of System Simulation

Abstract: With respect to the problem that single-index evaluation of visual quality in the process of intelligent combination of discrete Level-of-Detail (LoD) model for three-dimensional (3D) visualization can easily result in low reliability. Human visual perception and information entropy based multi-index fusion intelligent combination of discrete LoD model algorithm was proposed. Through analyzing the visual perception based image quality evaluation index, multi-index fusion evaluation intelligent combination of discrete LoD model framework was built. Comparative experiment with single index model combination bases on PSO method was designed. Model combination optimizing process utilized modified Particle Swarm Optimization (PSO) method which was strengthened …

Buford Named Director Of The Uab Center For Exercise Medicine, Staff

Browse All News

No abstract provided.

Data Wizards Join Fight Against Covid-19 In Uab Hackathon, Matt Windsor

Browse All News

No abstract provided.

New 2d Flow Visualization Method Based On Mutual Information And Image Fusion, Weihua Shen, Shengbo Wang, Zhigeng Pan

Journal of System Simulation

Abstract: A overview of flow visualization method based on information theory was made. After a comparative analysis of several classic two-dimensional flow visualization techniques, the concept of mutual information from information theory and image fusion technique was used to deal with the existing classical two-dimensional flow visualization techniques. A new two-dimensional flow visualization technique was obtained. The visualization results of the new method is very well.

2020-08-03 Newsletter, Morehead State University. Staff Congress.

Staff Congress Records

Staff Congress newsletter from August 3, 2020.

Interactions Of Photosensitizers With Model Membranes And Their Applications In Photodynamic Therapy, Poornima Kalyanram

Theses

Cancer is caused by the uncontrolled growth and spread of abnormal cells resulting in 1 in 6 deaths every day. The most common treatment methods include surgery, chemotherapy, and radiation. These techniques are invasive, aggressive, and non-specific to cancer cells. Therefore, alternative therapies which are both potent and does not interfere with the quality of living are on a rise. Photodynamic Therapy (PDT) is an approved alternative remedy in the treatment of cancer. The efficacy of PDT depends on the penetration power of the photosensitizer (PS) when injected into to the site of tumor. However, due to complexity involved in …

Mammals Of Cedar Breaks National Monument, S. Nicole Frey, Natalie D'Souza, Ethan Hammer, Bryan Larsen, Jake Nielson

All Current Publications

This document is the result of a study of the terrestrial mammals found at Cedar Breaks National Monument from 2017-2019. During this time, we conducted a survey of mammals using a series of trail cameras. We used survey results to provide an index of terrestrial mammals (excluding bats) within the park. Our goal is to provide a beginner’s guide to the mammals at Cedar Breaks National Monument. We include information regarding appearance, diet, habitat, and population status according to the International Union for the Conservation of Nature (IUCN). The guide represents the species a visitor to Cedar Breaks National Monument …

Evaluation Of Drugs For Potential Repurposing Against Covid-19 Using A Tier-Based Scoring System, Michael A. Jarvis, Frederick A. Hansen, Kyle Rosenke, Elaine Haddock, Christopher Rollinson, Simon Rule, Graham Sewell, Andrew Hughes, Heinz Feldmann

School of Biomedical Sciences

No abstract provided.

Valproic Acid Leads To An Increase In Ros Generation By Inhibiting The Deacetylation Of Mitochondrial Sod, Stephen Marc Lucas

Theses and Dissertations

Valproic Acid Promotes Acetylation of Superoxide Dismutase-2 During Neurogenesis. Valproic acid (VPA) is a known developmental toxicant associated with a high prevalence of neural tube defects (NTD). The mechanism of VPA-induced NTD is unclear, but oxidative stress may be implicated. To understand how embryotoxic oxidative stress may occur, we measured superoxide dismutase (SOD) activity following VPA treatment in the embryonic pluripotent P19 mouse carcinoma cell line. In undifferentiated P19 cultures treated with VPA (5 mM), dichlorofluorescein fluorescence increased 15% compared to untreated controls over 20 min, indicating a modest, yet statistically significant increase in ROS generation. Undifferentiated P19 cells were …

Discovery Of A Novel Regulatory Mechanism Of Tnk1 By 14-3-3 And Its Ubiquitin Association Domain Provides A Potential Therapeutic Targeting Opportunity In Cancer, Tsz Yin Chan

Theses and Dissertations

While a relatively limited number of known oncogenes underlie a large percentage of cancers, a variety of new genes have emerged as low-frequency cancer drivers. Each of these new oncogenes represents a frontier for targeted therapy. However, the discovery of low-frequency targetable oncogenic drivers is challenging. This study focuses on the poorly understood Tyrosine kinase non-receptor-1 (TNK1), which has been reported to have both oncogenic and tumor suppressive functions. TNK1 has been identified to promote cancer cells survival and promote chemoresistance in multiple independent studies. On the other hand, whole-body constitutive deletion of TNK1 in mice caused an increase in …

Imidacloprid Movement Into Fungal Conidia Is Lethal To Mycophagous Beetles, Robin A. Choudhury, Andrew M. Sutherland, Matt J. Hengel, Michael P. Parrella, W. Douglass Gubler

School of Earth, Environmental, & Marine Sciences Faculty Publications

Applications of systemic pesticides can have unexpected direct and indirect effects on nontarget organisms, producing ecosystem-level impacts. We investigated whether a systemic insecticide (imidacloprid) could be absorbed by a plant pathogenic fungus infecting treated plants and whether the absorbed levels were high enough to have detrimental effects on the survival of a mycophagous beetle. Beetle larvae fed on these fungi were used to assess the survival effects of powdery mildew and imidacloprid in a factorial design. Fungal conidia were collected from treated and untreated plants and were tested for the presence and concentration of imidacloprid. The survival of beetles fed …

2020-08-03 Minutes, Morehead State University. Staff Congress.

Staff Congress Records

Staff Congress meeting minutes from August 3, 2020.

Collaborative Research: Constraining The Tempo And Dynamics Of Cambrian Earth Systems In Western Laurentia, Carol M. Dehler

Funded Research Records

No abstract provided.

Aerobic Exercise Alters Opioid Receptors Following Chronic Alcohol Exposure, James N. Brundage

Theses and Dissertations

Opioid receptors have been a target of pharmacological manipulation in alcohol use disorder (AUD) recovery protocols for many years. Aerobic exercise, a common adjunct in AUD recovery, is known to modulate opioid receptors (ORs) both during both acute and long term exposure. The three subtypes of ORs: mu (MOR), delta (DOR), and kappa (KOR) are all expressed on neurons in the mesocorticolimbic circuitry. Kappa-opioid receptors are expressed directly on dopamine (DA) neuron terminals in the nucleus accumbens (NAc). Mu and Delta ORs are expressed on cholinergic interneurons (CINs) and GABA neurons in the NAc. In alcohol dependent rodents, KORs are …

Analyzing Metacommunity Models With Statistical Variance Partitioning: A Review And Meta-Analysis, Kevin Vieira Lamb

Theses and Dissertations

The relative importance of deterministic processes versus chance is one of the most important questions in science. We analyze the success of variance partitioning methods used to explain variation in β-diversity and partition it into environmental, spatial, and spatially structured environmental components. We test the hypotheses that 1) the number of environmental descriptors in a study would be positively correlated with the percentage of β-diversity explained by the environment, and that the environment would explain more variation in β-diversity than spatial or shared factors in VP analyses, 2) increasing the complexity of environmental descriptors would help account for more of …

Sarm1 Acts Downstream Of Neuroinflammatory And Necroptotic Signaling To Induce Axon Degeneration, Kwang Woo Ko, Jeffrey Milbrandt, Aaron Diantonio

Open Access Publications

Neuroinflammation and necroptosis are major contributors to neurodegenerative disease, and axon dysfunction and degeneration is often an initiating event. SARM1 is the central executioner of pathological axon degeneration. Here, we demonstrate functional and mechanistic links among these three pro-degenerative processes. In a neuroinflammatory model of glaucoma, TNF-α induces SARM1-dependent axon degeneration, oligodendrocyte loss, and subsequent retinal ganglion cell death. TNF-α also triggers SARM1-dependent axon degeneration in sensory neurons via a noncanonical necroptotic signaling mechanism. MLKL is the final executioner of canonical necroptosis; however, in axonal necroptosis, MLKL does not directly trigger degeneration. Instead, MLKL induces loss of the axon survival …

Men, Women And Witchcraft: The Feminist Reclamation Of The Witch In The Modern Horror Film, Brian Joseph Hadsell

Theses and Dissertations

The witch as a figure possesses a powerful and enduring legacy in Euro-American culture; she is both a victim of patriarchal persecution and the natural enemy of a deeply-gendered society. Recent horror films that employ the witch, however, have generally done so in the form of reclaimed feminist icon: a violently retributive figure avenging the wrongs done to women both past and present. The purpose of this research is to provide insight about our acutely gendered society and culture in the times during and preceding the #MeToo movement through a semiological analysis of three recent horror films that center on …

New Addiction And Pain Prevention Center Aims To Rally Researchers And Community, Matt Windsor

Browse All News

No abstract provided.

A Global Slc7a7 Knockout Mouse Model Demonstrates Characteristic Phenotypes Of Human Lysinuric Protein Intolerance, Bridget M Stroup, Ronit Marom, Xiaohui Li, Chih-Wei Hsu, Cheng-Yen Chang, Luan D Truong, Brian Dawson, Ingo Grafe, Yuqing Chen, Ming-Ming Jiang, Denise Lanza, Jennie Rose Green, Qin Sun, J P Barrish, Safa Ani, Audrey E Christiansen, John R Seavitt, Mary E Dickinson, Farrah Kheradmand, Jason D Heaney, Brendan Lee, Lindsay C Burrage

Faculty, Staff and Students Publications

Lysinuric protein intolerance (LPI) is an inborn error of cationic amino acid (arginine, lysine, ornithine) transport caused by biallelic pathogenic variants in SLC7A7, which encodes the light subunit of the y+LAT1 transporter. Treatments for the complications of LPI, including growth failure, renal disease, pulmonary alveolar proteinosis, autoimmune disorders and osteoporosis, are limited. Given the early lethality of the only published global Slc7a7 knockout mouse model, a viable animal model to investigate global SLC7A7 deficiency is needed. Hence, we generated two mouse models with global Slc7a7 deficiency (Slc7a7em1Lbu/em1Lbu; Slc7a7Lbu/Lbu and Slc7a7em1(IMPC)Bay/em1(IMPC)Bay; Slc7a7Bay/Bay) using CRISPR/Cas9 technology by introducing a deletion of exons …

Assessment Of Agricultural Advisory Messages From Farmer-To-Farmer In Making A Case For Scaling Up Production: A Qualitative Study, Nana Afranaa Kwapong, Daniel Adu Ankrah, Dominic Boateng-Gyambiby, Joseph Asenso-Agyemang, Lydia Oteng Fening

The Qualitative Report

Inadequate access to agricultural extension services often results in poor farm practices, affecting yields and subsequently the income and wellbeing of smallholder farmers. Given the high demand for agricultural information and the limited capacity of extension services, a farmer-to-farmer extension approach has been explored by many underserved farmers. In this study, we use a qualitative case study approach explore how cassava farmers who had limited access to agricultural advisory services from public extension agents managed to up-scale their farming business. Our research question was: what lessons can be learned from the lived experience of these farmers to address current challenges …

Emergent Risks In The Mt. Everest Region In The Time Of Anthropogenic Climate Change, Kr Miner, Pa Mayewski, Sk Baidya, K Broad, H Clifford, Ap Gajurel, B Giri, M Hubbard, C Jaskolski, H Koldewey, W Li, T Matthews, I Napper, B Perry, M Potocki, Jc Priscu, A Tait, R Thompson, S Tuladhar

School of Biological and Marine Sciences

No abstract provided.