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Searching For New Medications For The Treatment Of Alcohol Use Disorder, Harley M. Buechler

Theses and Dissertations

Alcohol use disorder (AUD) affects more than 15 million people in the United States. Current pharmacotherapeutic treatments for AUD are only modestly effective, necessitating the identification of new targets for medications development. In this study, the effects of the D4 receptor antagonist, L-745,870, and the CB1 negative allosteric modulator, PSNCBAM-1, were both tested for effects in ethanol conditioned place preference (CPP) and oral ethanol self-administration. Food-restricted adult male mice were trained in operant chambers to nose poke for delivery of rewards, trained on ascending concentrations of alcohol with descending concentrations of Ensure and water, until the mixture self-administered was 8% …

Book Review: George Will's Conservatism And Democracy In Crisis, Joseph Romance

eJournal of Public Affairs

No abstract provided.

A Practical Guide To Mechanistic Systems Modeling In Biology Using A Logic-Based Approach, Anna Niarakis, Tomáš Helikar

Department of Biochemistry: Faculty Publications

Mechanistic computational models enable the study of regulatory mechanisms implicated in various biological processes. These models provide a means to analyze the dynamics of the systems they describe, and to study and interrogate their properties, and provide insights about the emerging behavior of the system in the presence of single or combined perturbations. Aimed at those who are new to computational modeling, we present here a practical hands-on protocol breaking down the process of mechanistic modeling of biological systems in a succession of precise steps. The protocol provides a framework that includes defining the model scope, choosing validation criteria, selecting …

Parent Responses To Pediatric Pain: The Differential Effects Of Ethnicity On Opioid Consumption, Candice D. Donaldson, Brooke N. Jenkins, Michelle A. Fortier, Michael T. Phan, Daniel M. Tomaszewski, Sun Yang, Zeev N. Kain

Psychology Faculty Articles and Research

Objective

Within the context of the United States opioid epidemic, some parents often fear the use of opioids to help manage their children's postoperative pain. As a possible consequence, parents often do not dispense optimal analgesic medications to their children after surgery, putting their children at risk of suffering from postsurgical pain. The objective of this research was to assess ethnicity as a predictor of both pain and opioid consumption, and to examine how Hispanic/Latinx and Non-Hispanic White parents alter their child's opioid consumption in response to significant postsurgical pain.

Methods

Participants were 254 children undergoing outpatient tonsillectomy and/or adenoidectomy …

Antimicrobial Resistance Surveillance In Low- And Middle-Income Countries: Progress And Challenges In Eight South Asian And Southeast Asian Countries, Sumanth Gandra, Gerardo Alvarez-Uria, Paul Turner, Jyoti Joshi, Direk Limmathurotsakul, H. Rogier Van Doorn

Open Access Publications

SUMMARYAntimicrobial resistance (AMR) is a serious global health threat and is predicted to cause significant health and economic impacts, particularly in low- and middle-income countries (LMICs). AMR surveillance is critical in LMICs due to high burden of bacterial infections; however, conducting AMR surveillance in resource-limited settings is constrained by poorly functioning health systems, scarce financial resources, and lack of skilled personnel. In 2015, the United Nations World Health Assembly endorsed the World Health Organization's Global Action Plan to tackle AMR; thus, several countries are striving to improve their AMR surveillance capacity, including making significant investments and establishing and expanding surveillance …

Rsif Weekly Vol.1 No.16, Regional Scholarship And Innovation Fund (Rsif)

Rsif Newsletters

No abstract provided.

Covid-19: Fighting The Invisible Enemy With Microrna, Neeraj Chauhan, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu

School of Medicine Publications

Introduction: The novel coronavirus (CoV) disease 2019 (COVID-19) is a viral infection that causes Severe Acute Respiratory Syndrome. It is believed that early reports of COVID-19 cases were noticed in December 2019 and soon after became a global public health emergency. It is advised that COVID-19 transmits through human to human contact and in most cases it remains asymptomatic. Several approaches are being utilized to control the outbreak of this fatal viral disease. microRNAs (miRNAs) are known signature therapeutic tool for the viral diseases; they are small non-coding RNAs that target the mRNAs to inhibit their post-transcriptional expression, therefore, impeding …

Points Of Pride, Georgia Southern University

Points of Pride (2013-2023)

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Prophylactic Mesh Placement For The Prevention Of Incisional Hernia In High-Risk Patients After Abdominal Surgery: A Systematic Review And Meta-Analysis, Jawad Ahmed, Nimra Hasnain, Iayla Fatima, Farheen Malik, Muhammad A. Chaudhary, Junaid Ahmad, Mehreen Malik, Laraib Malik, Muhammad Osama, Mirza Zain Baig, Faisal Khosa, Faiz Bhora

Department of Anaesthesia

Background and objectives: In high-risk populations, the efficacy of mesh placement in incisional hernia (IH) prevention after elective abdominal surgeries has been supported by many published studies. This meta-analysis aimed at providing comprehensive and updated clinical implications of prophylactic mesh placement (PMP) for the prevention of IH as compared to primary suture closure (PSC).
Materials and methods: PubMed, Science Direct, Cochrane, and Google Scholar were systematically searched until March 3, 2020, for studies comparing the efficacy of PMP to PSC in abdominal surgeries. The main outcome of interest was the incidence of IH at different follow-up durations. All statistical analyses …

Men And Covid-19: A Pathophysiologic Review, Martin S. Lipsky, Man Hung

Institute on Aging Publications

Coronaviruses are single-stranded ribonucleic acid viruses that can cause illnesses in humans ranging from the common cold to severe respiratory disease and even death.In March 2020, the World Health Organization declared the 2019 novel coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as the first pandemic. Compared to women, most countries with available data report that men with COVID-19 have greater disease severity and higher mortality. Lab and animal data indicate that men respond differently to the SARS-CoV-2 infection, offering possible explanations for the epidemiologic observations. The plausible theories underlying these observations include sex-related differences …

Transitioning Into Conventional Housing: Narratives Of Houseless Individuals, Joyce La Belle Mcnair

Dissertations and Theses

Past research has shown that it is possible for individuals to exit houselessness. However, it does little to provide insights into the types of experiences and events that facilitate these moves towards housing stability. This study explores indepth interviews, utilizing an interview guide with 12 individuals who exited houselessness in Portland, Oregon. This research project seeks to understand the conditions that influence successful exits out of houselessness from the perspective of the lived experiences of once houseless individuals. This study utilizes two theoretical frameworks, the theory of Habitus (Bourdieu, 1977 & Wacquant, 1998) and the networking theory of Strong and …

Engaging Communities In Archaeology On Private Property In An Urban Neighborhood: The Search For The First (1825-1829) Fort Vancouver, Vancouver, Washington, Amy Carolyn Clearman

Dissertations and Theses

Current archaeological literature calls for archaeology to become increasingly relevant in the modern world. Involvement in archaeological research can enhance the relevancy of archaeology for participants of public archaeology projects by strengthening personal connections with heritage and history. To investigate the impact of direct involvement in archaeological research on residents in Vancouver, Washington, I recruited members of two neighborhoods associated with Fort Vancouver National Historic Site to participate in the archaeological search for material remains of the first (1825-1829) Fort Vancouver. I asked the question: How does involvement in a public archaeology project affect participants' feelings about heritage, archaeology, and …

Role Of Grazing Cattle On Seed Dispersal Of Plants In A Hill Pasture 4. Effects Of Dung Patch On Environmental Condition In Dung And Seedling Establishment, Shin-Ichiro Ogura, S. Tanaka, S. Sato

IGC Proceedings (1977-2023)

No abstract provided.

Role Of Grazing Cattle On Seed Dispersal Of Plants In A Hill Pasture 3. Seasonal Variation Of Locations Of Defecation By Cattle And Its Effects On Germination Of Seeds In Dung Pats, Shin-Ichiro Ogura, M. Obara, T. Shishido, K. Sugawara

IGC Proceedings (1977-2023)

No abstract provided.

Combining Biodiversity Enhancement Of Temperate Grassland With Sustainable Organic Production Of Traditional Breed Livestock, Mark P. O'Brien, W. Elizabeth Vice, Humphrey G. Smith

IGC Proceedings (1977-2023)

No abstract provided.

Role Of Grazing Cattle On Seed Dispersal Of Plants In A Hill Pasture 2. Effects Of Ruminal Digestion On Seed Germinability Of Five Plant Species, M. Obara, Shin-Ichiro Ogura, T. Shishido, K. Sugawara

IGC Proceedings (1977-2023)

No abstract provided.

Role Of Grazing Cattle On Seed Dispersal Of Plants In A Hill Pasture 1. Effect Of Sward Structure On Grass Seed Ingestion By Cattle, M. Obara, Shin-Ichiro Ogura, T. Shishido, K. Sugawara

IGC Proceedings (1977-2023)

No abstract provided.

An Innovative Integrated Modelling Tool To Assess And Design Territorial Crop-Livestock Systems, Rui Catarino

International Congress on Environmental Modelling and Software

Fostering local exchanges between specialized arable and livestock farms can simultaneously help to develop crop diversification and re-localization of livestock feed production, two major sustainability challenges of industrial agriculture. However, the aggregated benefits and drawbacks of developing a “Territorial Crop-Livestock System” (TCLS) based on exchanges is yet to be stablished. A major lock-in is the lack of decision support systems to analyse the underpinning dynamics and associated uncertainties of necessary socio-technical changes and to design necessary organizational aspects within and among farms. This paper presents an innovative high-resolution multi-agent and dynamic spatial modelling framework of agricultural landscape, MAELIA, developed to …

Effect Of Hydroalcoholic Allium Atroviolaceum L. On The Pathology Of Testicular Tissue In Cyclophosphamide-Treated Mice, Mehrdad Shahrani, Shirin Asgharian, Alireza Hosseini, Elham Bijad, Maryam Anjomshoa, Ayoob Rostamzadeh, Najmeh Asgharzadeh, Zahra Lorigooini

BioMedicine

Background: The most important side effects of Cyclophosphamide, as an anticancer broad-spectrum drug, are the negative effects on the reproduction and fertility because of oxidative stress. Considering the antioxidant properties of medicinal plants, especially those of the Allium genus, this paper studied the effect of hydroalcoholic extract of Allium atroviolaceum L. on the pathology of testicular tissue in CP-treated mice.

Methods: Groups of this experimental study consisted of normal saline recipients; three groups receiving A. atroviolaceum extract at 50, 100, 200 mg/kg; three groups receiving A. atroviolaceum extract at 50, 100, and 200 mg/g and 6.6 mg/kg of Cyclophosphamide; …

Gower´S Queer Poetics In The Mirour De L'Omme, María Bullón-Fernández

Accessus

Gower's Queer Poetics in the Mirour de l'Omme

In the Mirour de l’Omme John Gower describes the allegorical Sins as both deceitful and “hermafrodrite” and later confesses to having engaged in queer practices in his earlier courtly poetry. Gower’s confession and his association of the Sins with intersexuality, I will argue, do not entail ultimately a rejection of queer poetics. In his Life of the Virgin Mary, the final part of the Mirour, Gower deploys a different kind of queer poetics, one that acknowledges the indeterminacies of language but still seeks to stabilize meaning, while intertwining male and female.

The Concept Of Natureculture Document: A Conceptual Exploration Of Seeds, Embodied Information, And Unconventional Records, Marc Kosciejew

Journal of Contemporary Archival Studies

Seedbanks, or so-called archival arks of the apocalypse, are addressing accelerating anthropocentric alterations to the environment by collecting, storing, and preserving seeds. These are specialized archival repositories that approach, frame, and use seeds as documents for agricultural and scientific research, classification and preservation work, and various other archival and administrative purposes. Seedbanks indeed are archives of unconventional records.

This article introduces the concept of natureculture document as a framing device in which to help analyze the documentary status of objects that are not necessarily or usually considered as documents or having documentary characteristics. This concept, coupled with its interdisciplinary theoretical …

Journal Of John Lee Williams, Florida Historical Society

Florida Historical Quarterly

Journal of a voyage from Pensacola to St. Marks and the district of country included between the rivers Ocholockney and Suwannee, in West Florida, during the months of October and November, 1823.

Indian Massacre In Gadsen County, Florida Historical Society

Florida Historical Quarterly

Sixteen miles southwest of Quincy, the county seat of the grand old county of Gadsden, and about a mile from the banks of the Tallogee creek, spelled on the maps Taliga, lives John K. McLane, now in his eighty-third, year, and a descendant of those, sturdy old Scotch colonists who have contributed so much to the history of this republic.

Origin Of The Shell Mounds, Florida Historical Society

Florida Historical Quarterly

Modern methods of traveling and the corresponding number of travelers, permitting easy access to all parts of the civilized world; and especially throughout the United States, cause many persons to spend their winters in a semi-tropical climate, thereby combining the opportunity to escape the rigor of winter and secure that change of climate condusive to health and happiness. To entertain this vast concourse of people, whose dispositions and tastes vary almost as much as their personal appearance, is no small matter. For the success of each city or locality, in obtaining its proportion of tourists is in proportion to their …

Antagonistic Interactions Between Foliar Endophytes And Root Mycorrhizal Symbionts Of Lolium Perenne, Q. Liu, A. J. Parsons, J. A. Newman, H. Xue, Susanne Rasmussen

IGC Proceedings (1977-2023)

No abstract provided.

Alternative Perennial Legumes On Acid Soils In Southern New South Wales, Australia, Guangdi Li, Richard C. Hayes, B. S. Dear

IGC Proceedings (1977-2023)

No abstract provided.

Diet Selection And Intake Of Yak (Bos Grunniens) In Warm‐And Cold‐Season Paddocks Of Potentilla Fruticosa Rangeland In Northern Qinghai‐Tibetan Plateau, Guomei Li, Nobumi Hasegawa, Rende Song, Youliang Wang, Shengqing Feng

IGC Proceedings (1977-2023)

No abstract provided.

Long‐Term Cattle Grazing Effects On Soil Chemistry In The Rough Fescue Grassland, Chunli Li, Walter D. Willms, Xiying Hao, Ben Ellert, Mengli Zhao, Guodong Han

IGC Proceedings (1977-2023)

No abstract provided.

Bricks Ucc-Approved Courses, September 15, 2020, General Education Committee

General Education Committee

No abstract provided.

Executive Committee - Meeting Minutes, 9/15/2020, Academic Senate Executive Committee

Academic Senate Minutes

No abstract provided.