Digital Commons Network^™

Green Completion As A Mitigation For Btex Exposure In Gas Flaring: Nigeria Case Study (Exposure Assessment And Cost Model), Akintunde S. Akinyemi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Gas flaring is an essential part of the oil and gas industry safety and waste management procedures; however, it presents a potential exposure to BTEX compounds, a group of Non-Methane Volatile Organic Compounds (NMVOC), within up to a 10-mile radius of the flare point. The physical and the psychological cost of the journey to work, make employees live close to the workplace. This study examined the perceived exposure of oil and gas industry workers to possible carcinogenic emissions outside the workplace. It looked at the outcomes of the exposure to BTEX through gas flaring drawing on archival data and using …

The Role Of Law And Policy In Achieving Healthy People's Disability And Health Goals Around Access To Health Care, Activities Promoting Health And Wellness, Independent Living And Participation, And Collecting Data In The United States, Elizabeth Pendo, Lisa Iezzoni

All Faculty Scholarship

Ensuring that the almost 60 million Americans with disabilities live as healthy and independent lives as possible is an important goal for our nation. This evidence-based report highlights efforts to better use law and policy to support and protect people with disabilities. Specifically, it examines how existing federal laws and policies could be leveraged by states, communities, and other sectors to reduce barriers to primary and preventive care; reduce barriers to local health and wellness programs; increase access to leisure, social, or community activities (and indirectly, to religious activities) for individuals with disabilities; and generate better disability data needed to …

Taking Employment Contracts Seriously, Matthew T. Bodie

All Faculty Scholarship

The essay, written for the Symposium in Honor of the Work of Charles A. Sullivan, examines the honoree's work on the employment contract. Rather than quickly moving past the common law of contract onto the many statutory regimes governing the workplace, Sullivan has repeatedly explored the nature of the employment agreement and the role of common-law doctrines in regulating this relationship. The essay explores Sullivan's expeditions into the common law and compares his work with those scholars working in the private law and New Private Law traditions. In addition, I argue that the contractual approach has failed to appreciate the …

Legalizing Midwifery In Missouri, Michael A. Wolff

All Faculty Scholarship

Two decades after the Missouri Supreme Court upheld an injunction against the practice of midwifery, two midwives became lobbyists for the cause and, with the remarkable cooperation of friendly legislators and lobbyists, got a provision inserted in a health bill legalizing the practice of tocology, a synonym for midwifery that went unnoticed by legislators who voted for the lengthy bill in which it was inserted. Medical associations sued to invalidate this "stealth" provision but their efforts failed when the Missouri Supreme Court declined to grant standing to the doctors to "protect" the interests of the public. Thirteen years later, the …

Helicobacter Pylori Gene Regulation By Virulence Region Located Srnas, Veronica Janette Albrecht

EWU Masters Thesis Collection

Approximately 50% of the human population is infected with Helicobacter pylori, which can lead to gastrointestinal diseases such as ulcers and gastric adenocarcinoma. Helicobacter pylori strains are genetically variable, and some contain a DNA region called the cytotoxin associated gene pathogenicity island (cagPAI) that encodes virulence factors. Gastrointestinal disease associated with H. pylori are more likely to occur in infections with cagPAI positive strains. Helicobacter pylori has few known transcriptional regulators, but still must regulate expression to survive a constantly changing environment. A mechanism to facilitate this regulation was revealed in a transcriptome analysis conducted by Sharma et al. (2010) …

Kinetics Of Notch Signaling During Osteoclastogenesis, Amber Larissa Framstad

EWU Masters Thesis Collection

Bone remodeling, the process of removing and replacing damaged bone matrix, is a dynamic physiological process essential to maintaining bone composition and integrity. Improper coordination of resorption and formation can lead to pathologic changes in bone composition and quality, as is seen in osteoporosis, a bone disorder most seen in post-metapausal women attributed to decreased estrogen levels. The Notch signal pathway is a highly conserved direct cell communication pathway known to regulate cell proliferation, differentiation and survival in many cell types including the differentiation of osteoclasts from bone marrow macrophages (BMMs). Osteoclastogenesis is initiated in BMMs by receptor activator of …

Love In The Time Of Climate Change, Caroline Woodwell

EWU Masters Thesis Collection

No abstract provided.

Intrauterine Exposure To Chronic Hypoxia In The Rat Leads To Progressive Diastolic Function And Increased Aortic Stiffness From Early Postnatal Developmental Stages, Praveen Kumar, Jude S. Morton, Amin Shah, Victor Do, Consolato Sergi, Jesus Serrano-Lomelin, Sandra T. Davidge, Donna Beker, Jody Levasseur, Lisa K. Hornberger

School of Medicine Publications

Aim

We sought to explore whether fetal hypoxia exposure, an insult of placental insufficiency, is associated with left ventricular dysfunction and increased aortic stiffness at early postnatal ages.

Methods

Pregnant Sprague Dawley rats were exposed to hypoxic conditions (11.5% FiO2) from embryonic day E15‐21 or normoxic conditions (controls). After delivery, left ventricular function and aortic pulse wave velocity (measure of aortic stiffness) were assessed longitudinally by echocardiography from day 1 through week 8. A mixed ANOVA with repeated measures was performed to compare findings between groups across time. Myocardial hematoxylin and eosin and picro‐sirius staining were performed to evaluate myocyte …

Leaf Angle And Leaf Stomata Responses To Experimental Drought In Quercus Velutina And Acer Saccharum, Brittany Nichole Casey

Graduate Theses, Dissertations, and Problem Reports (ETD)

The possibility of increased severity and frequency of drought conditions, as a result of global climate variability, greatly complicates our ability to forecast future forest functions such as productivity and carbon sequestration. Assessing how tree species vary in their response to drought can aid in predicting the impact on forest ecosystems as a whole. Throughfall exclusion (TfE) experiments are potentially useful tools to simulate realistic drought conditions within intact forest ecosystems. We employed a TfE experiment during the 2018 growing season within the WV Land Trust’s Elizabeth’s Woods Nature Preserve, near Morgantown, WV, to assess the leaf angle and leaf …

Predictors Of Self-Control During Emerging Adulthood: The Roles Of Implicit Beliefs And Early Risk, Katy L. Delong

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study explored how early adverse experiences (i.e., low socioeconomic status, household chaos, attachment insecurity) and implicit beliefs about self-control (i.e., whether self-control is a limited or nonlimited resource) were associated with trait and momentary self-control in a sample of college students. As the first study to explore these factors together, individuals’ implicit beliefs were tested as a moderator and meditator of the association between early risk and self-control. Participants (N = 214) first completed a baseline survey with the main predictors and trait self-control, followed by one week of experience sampling to assess momentary self-control, or success resisting …

The Immunological Response To Chronic Stress In Obese Mice, Matthew Corey Parsley

Graduate Theses, Dissertations, and Problem Reports (ETD)

Obesity and psychological stress are major risk factors for cardiovascular disease and have a positive correlation with vascular dysfunction. This functional deficit has been linked to a pro-inflammatory milieu, exacerbated by an upregulation of pro-inflammatory cytokines. Febuxostat, a xanthine oxidase inhibitor, has been shown to rescue vascular impairment in these models. The purpose of this study was to examine the individual and combined effects of obesity and chronic stress on neuroimmune cell populations, and assess if febuxostat is able mediate immune alterations.

Male mice (n=48) were assigned into either normal chow (lean) and high-fat diet (obese) groups. The lean animals …

Innovative Approaches To 3d Gis Modeling For Volumetric And Geoprocessing Applications In Subsurface Infrastructures In A Virtual Immersive Environment, Pragya Srivastava

Graduate Theses, Dissertations, and Problem Reports (ETD)

As subsurface features remain largely ‘out of sight, out of mind’, this has led to challenges when dealing with underground space and infrastructures and especially so for those working in GIS. Since subsurface infrastructure plays a major role in supporting the needs of modern society, groups such as city planners and utility companies and decision makers are looking for an ‘holistic’ approach where the sustainable use of underground space is as important as above ground space. For such planning and management, it is crucial to examine subsurface data in a form that is amenable to 3D mapping and that can …

Prescribing The Profession: Representations Of Medical Professionalization Debates In American Literary Forms, 1830-1940, Jeffrey Wayne Yeager

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation traces the debates concerning the professionalization of medicine in America across the 19^th- and well into the 20^th-century and explores how the debates concerning professionalization in any given moment affected popular literary forms. Using Fredric Jameson’s The Political Unconscious as its theoretical framework, this dissertation’s chapters on the gothic, realism, naturalism, and satire trace each mode’s dominant hegemonic position on this issue while showcasing dissenting voices across this century-long discourse. This project’s methodology is centered in the New Historicism. Unlike other projects before it, this dissertation focuses primarily on the historical problem of state …

Clear Aligner Therapy Vs. Traditional Brackets On Smile Arc, Sarah Elizabeth Larue

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background and Objectives: More so than ever, the public is becoming exceedingly aware of esthetics, and will evaluate their treatment outcome based upon the improvement to their smile and overall enhancement of their facial appearance. Smile arc is considered to be a key component of facial esthetics. Literature has demonstrated that orthodontic treatment mechanics utilizing traditional brackets and wires can cause flattening of the smile arc and that smiles with flatter arcs are judged to be less attractive. The aim of this study was to determine whether clear aligner therapy can help to preserve or improve the smile arc …

A Flight Sensory-Motor To Olfactory Histamine Circuit Mediates Olfactory Processing Of Ecologically And Behaviorally Natural Stimuli, Samual P. Bradley

Graduate Theses, Dissertations, and Problem Reports (ETD)

Environmental pressures have conferred species specific behavioral and morphological traits to optimize reproductive success. To optimally interact with their environment, nervous systems have evolved motor-to-sensory circuits that mediate the processing of its own reafference. Moth flight behavioral patterns to odor sources are stereotyped, presumably to optimize the likelihood of interacting with the odor source. In the moth Manduca sexta wing beating causes oscillatory flow of air over the antenna; because of this, odorant-antennal interactions are oscillatory in nature. Electroantennogram recordings on antennae show that the biophysical properties of their spiking activity can effectively track odors presented at the wing beat …

Impact Of Sire Selection And Breed On Parasite Resistance In Sheep, Andrew Ryan Weaver

Graduate Theses, Dissertations, and Problem Reports (ETD)

Selection within and among breeds are strategies to mitigate the impact of parasitism given failing chemotherapeutics. While Texels have improved marketability compared to other parasite-resistant breeds, the mechanism by which Texels reduce fecal egg count (FEC) is unclear. The immune response to Haemonchus contortus (Hc) was compared in Texel, parasite-resistant St. Croix, and parasite-susceptible Suffolk sheep. Adult worms exposed to St. Croix- and Texel-derived peripheral blood mononuclear cells and serum in vitro had greater binding around the reproductive structures than Suffolk and worm egg release tended to be affected by breed (P = 0.09). Resistance in Texels …

Evolutionary Genomics Of Dynamic Sex Chromosomes In The Salicaceae, Ran Zhou

Graduate Theses, Dissertations, and Problem Reports (ETD)

Identifying the sex-determination region (SDR) and other genomic features of sex chromosomes are of great importance in the studies of the evolution of sex. However, the process of accurately identifying the size and location of the SDR is often difficult, even when a genomic sequence is available. This usually is hindered by large repetitive elements and a lack of recombination in the SDR. In this thesis, I assemble sex chromosomes with whole genomic sequencing data, identify SDRs and explore their genomic features in two sister species from the Salicaceae family. I also develop an interpretation of the lability of the …

Neuroimaging Of Real-World Audio-Visual Sensory Integration In High-Functioning Autism, Paula J. Webster

Graduate Theses, Dissertations, and Problem Reports (ETD)

Sensory processing differences are a prevalent aspect of autism spectrum disorder (ASD) that may contribute to core deficits of ASD such as repetitive behaviors as well as comorbidities including anxiety disorders. The ability to integrate information among our senses is required to comprehend the world around us and is crucial for the development of language, motor skills, and social communication. Prior studies have shown that individuals with autism differ from individuals without autism when presented with simple, non-natural audio-visual stimuli such as basic shapes accompanied by pure tones. Because the human brain processes non-natural and natural stimuli differently, more recent …

The Spatial Historian: Creating A Spatially Aware Historical Research System, James P. Schindling

Graduate Theses, Dissertations, and Problem Reports (ETD)

The intent of this study is to design a geospatial information system capable of facilitating the extraction and analysis of the fragmentary snapshots of history contained in hand-written historical documents. This customized system necessarily bypasses off-the-shelf GIS in order to support these unstructured primary historical research materials and bring long dormant spatial stories previously hidden in archives, libraries, and other documentary storage locations to life. The software platform discussed here integrates the tasks of information extraction, data management, and analysis while simultaneously giving primary emphasis to supporting the spatial and humanistic analysis and interpretation of the data contents. The premise …

Interpretations Of Bicoherence In Space & Lab Plasma Dynamics, Gregory Allen Riggs

Graduate Theses, Dissertations, and Problem Reports (ETD)

The application of bicoherence analysis to plasma research, particularly in non-linear, coupled-wave regimes, has thus far been significantly belied by poor resolution in time, and/or outright destruction of frequency information. Though the typical power spectrum cloaks the phase-coherency between frequencies, Fourier transforms of higher-order convolutions provide an n-dimensional spectrum which is adept at elucidating n-wave phase coherence. As such, this investigation focuses on the utility of the normalized bispectrum for detection of wave-wave coupling in general, with emphasis on distinct implications within the scope of non-linear plasma physics. Interpretations of bicoherent features are given for time series from …

Two Approaches To Analyzing Institutions’ Spending Responses To Campus Sexual Assault, Amanda M. Rose

Graduate Theses, Dissertations, and Problem Reports (ETD)

Despite occupying a growing portion in contemporary U.S. higher education institutions’ annual budgets, empirical research on sexual assault costs is limited. The purpose of this study is to look at whether incidences of sexual violence on campus are associated with increased costs in policies and programs geared toward prevention of these crimes. Informing the analysis is a theoretical framework consisting of the revenue theory of costs and positional arms race theory. This study examines data from both IPEDS and the U.S. Department of Education Crime and Safety website over a ten year period, 2006-2015, for a set of over 2,300 …

Utilizing Conservation Genetics As A Strategy For Recovering The Endangered Candy Darter (Etheostoma Osburni) In West Virginia, Brin E. Kessinger

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Candy Darter (Etheostoma osburni) is a small freshwater fish native to the New River drainage in West Virginia and Virginia that was listed as endangered in November 2018. It has been extirpated from much of its historic range in West Virginia, restricting it to the Gauley and Greenbrier river drainages. In addition to extirpations, the species is threatened by introgressive hybridization with the invasive Variegate Darter (E. variatum). Previous research primarily focused on hybridization, but population genetic analyses were limited. Population genetic analyses aim to identify distinct populations through genetic structure and characterize the levels …

Role Of Ciliary Proteins Adp Ribosylation Factor Like Gtpase 13b (Arl13b) And Bardet-Biedl Syndrome-8 (Bbs8) In Photoreceptor Outer Segment Morphogenesis, Maintenance, And Viability, Tanya L. Dilan

Graduate Theses, Dissertations, and Problem Reports (ETD)

Photoreceptor neurons are modified primary cilia with an extended ciliary compartment known as the outer segment (OS). The mechanisms behind the elaboration of photoreceptor cilia, OS morphogenesis, and maintenance remain poorly understood. In this work, we focused on dissecting the role of two ciliary proteins, the small GTPase ADP-ribosylation factor-like GTPase 13B (ARL13B) and Bardet-Biedl Syndrome-8 (BBS8) in the context of photoreceptor biology. Both BBS8 and ARL13B are linked to defects in ciliogenesis (cilia development) and Retinitis Pigmentosa (vision loss). ARL13B is implicated in regulating ciliary length, and BBS8 is part of the Bardet-Biedl Syndrome complex (BBSome); the BBSome is …

Alternative Media And Mulches In Organic Vegetable Production, Heather R. Griffith

Graduate Theses, Dissertations, and Problem Reports (ETD)

Reducing or eliminating waste from organic vegetable production can conserve money as well as resources. Conventional greenhouse production of vegetable transplants often relies on abundant fertigation which produces large amounts of polluted runoff, and the field production of organic vegetables frequently relies on the use of polyethylene mulch. A greenhouse study was conducted to determine if organic transplants can be successfully produced in a greenhouse under reduced soil moisture in order to reduce leaching of nutrients and potential water pollution. To test this, we compared the effect of reduced irrigation volumes to the standard practice of irrigating with 120% of …

Shaping Urban Spaces To Fit Into Religious Boundaries Through Landscape, Niharika Alahari

Graduate Theses, Dissertations, and Problem Reports (ETD)

In India, rivers are considered a sacred entity for Hindus and temples on the banks of rivers are a common sight in Indian architectural character. Devotees come to worship and perform small ceremonies on ghats, banks of the river, to the gods and ancestors. This is considered a part of an important ritual prior to entering the temple associated with the river. One such river in South India where this practice occurs, is the Krishna river in Vijayawada, an important pilgrimage center for devotees and the location for this study. Although this practice is a daily occurrence and one hundred …

The Roman Catholic Ordinary Mass From Circa 1750 To Circa 1820: A Selected Bibliography, Letícia Gabriele Grützmann Januario

Graduate Theses, Dissertations, and Problem Reports (ETD)

Orchestrated masses from the 18th century and early years of the 19th century provide a valuable source of repertoire for contemporary choral conductors. This project will explore composers and works from circa 1750 to 1820 to provide choral conductors with a list of works suitable for programming based on the practical size of vocal and instrumental forces.

Western choral music was born in a church setting. Among all choral genres, the mass is the only genre composed throughout all eras, from medieval until the 20th century. The mass remained a prominent genre during the 18th century despite the secularizing influence …

Evaluation Of Salmonella Enteritidis And Escherichia Coli O157:H7 Volatile Organic Compound Analysis For Food Safety Monitoring: A Preliminary Study, Jessica E. Lemley

Graduate Theses, Dissertations, and Problem Reports (ETD)

Food borne illness has the potential to impact every point of production from producers to consumers. Food product recalls are common due to the presence of food borne illness causing bacteria. Detection of volatile organic compounds (VOC) have the potential to reduce the number of illnesses and recalls through application of additional monitoring of food products like those most commonly recalled. The objective of this research was to 1) explore the use of closed-loop headspace analysis coupled with gas chromatography-mass spectrometry (GC-MS) on food borne illness causing bacteria and 2) examine the VOC profile of Escherichia coli serotype O157:H7 in …

The Host Gatekeeper: Using The Flagellar Pathway To Understand Symbiont Host Adaptation, Adam R. Pollio

Graduate Theses, Dissertations, and Problem Reports (ETD)

The acquisition of microbial partners is a strategy used by a diverse group of arthropods to overcome ecological barriers that might normally make certain niches uninhabitable. The unique phylogenetic opportunities attainable from the natural experiment of the Sodalis-allied clade allow for better understanding of how molecular structures evolve through time. Here, we focus on the evolution of the flagellar synthesis pathway, due to its complexity and ability to diverge in response to ecological pressures. We used this molecular pathway and natural experiment to show that normal evolutionary outcomes associated with symbiosis (i.e., genome reduction) do not explain the predicted conservation …

Root Coverage Predictability In The Treatment Of Gingival Recessions On Mandibular And Anterior Teeth, Michele Agusto

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction. Mandibular anterior teeth are most frequently affected by gingival recessions. However, data regarding mucogingival treatment aimed at root coverage in this specific location is limited.

Aim. To systematically review the literature addressing the focused question: “What is the effectiveness, efficacy and efficiency of different surgical approaches on clinical and patient-related outcomes in the treatment of buccal gingival recessions on mandibular anterior teeth?”

Material methods. Electronic (Medline, Scopus, and Cochrane databases) and hand literature searches were performed for studies including at least one arm involving the use of pedicle flaps and/or free soft tissue grafts in the …

Allopurinol Alters The Expression Of Cytokines And Mediators Of Immune Cells In The Systemic 2 Tissue By Decreasing Plasma Urate., Lundrim S. Marku

Graduate Theses, Dissertations, and Problem Reports (ETD)

Diminished levels of urate have been linked to oxidative stress in birds and mammals. Urate, a major antioxidant that lowers reactive oxygen/nitrogen species (ROS/RNS), is thought to ameliorate the effects. The relationship between reduced urate, the immune system and the pathogenesis of the intestine, the liver or the brain has not been well characterized in avians. Moreover, recent studies have proposed that an increased permeability in the intestine due to some insult can induce inflammation in peripheral organs such as the brain. Allopurinol, a relatively toxic purine analogue that serves as a xanthine oxidase inhibitor, reduces urate levels which can …