Digital Commons Network^™

Allopurinol Alters The Expression Of Cytokines And Mediators Of Immune Cells In The Systemic 2 Tissue By Decreasing Plasma Urate., Lundrim S. Marku

Graduate Theses, Dissertations, and Problem Reports (ETD)

Diminished levels of urate have been linked to oxidative stress in birds and mammals. Urate, a major antioxidant that lowers reactive oxygen/nitrogen species (ROS/RNS), is thought to ameliorate the effects. The relationship between reduced urate, the immune system and the pathogenesis of the intestine, the liver or the brain has not been well characterized in avians. Moreover, recent studies have proposed that an increased permeability in the intestine due to some insult can induce inflammation in peripheral organs such as the brain. Allopurinol, a relatively toxic purine analogue that serves as a xanthine oxidase inhibitor, reduces urate levels which can …

Analysis Of Factors Influencing The Stationarity Of Surface Electromyography Signals Measured In Non-Fatigued Shoulder Muscles, Hui Ci

Graduate Theses, Dissertations, and Problem Reports (ETD)

A reduction in the % stationarity of surface electromyography (SEMG) signals with respect to the initial or fresh condition is used to predict localized muscle fatigue. However, factors other than muscle fatigue can also influence the stationarity of SEMG signals. This study was aimed at analyzing the effect of various work/task related factors on the stationarity of SEMG signals obtained from non-fatigued shoulder muscles. Twelve participants were recruited for data collection and each one performed 120 trials characterized by the combination of 2 shoulder angles (60° and 120°), 2 planes of exertions (sagittal and scapular), 3 force levels (0lb, 2.5lb, …

Clincial Translational Science Research Of The Functional Role Of Large Conductance Potassium Channels In Selective Destruction Of Triple Negative Breast Cancer Cells, Gina Sizemore

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

The preliminary background that puts this research into context is threefold; it is the aggressive nature of triple negative breast cancer (TNBC), the complexity surrounding its pathology, and the significant lack of targeted treatment for this disease. To clarify the focus of my research, I have concentrated on identifying a targeted treatment for TNBC. In the process, I have identified cycles of reciprocity between treatment, clinical diagnosis, staging, and pathology that will be addressed in smaller papers. However, the weight of this work is in the discovery of a novel target for triple negative breast cancer. The value of …

Haruka's World, Julia M. Chin

The Mercury

No abstract provided.

Towards Automated Infographic Design: Deep Learning-Based Auto-Extraction Of Extensible Timeline, Zhutian Chen, Yun Wang, Qianwen Wang, Yong Wang, Huamin Qu

Research Collection School Of Computing and Information Systems

Designers need to consider not only perceptual effectiveness but also visual styles when creating an infographic. This process can be difficult and time consuming for professional designers, not to mention non-expert users, leading to the demand for automated infographics design. As a first step, we focus on timeline infographics, which have been widely used for centuries. We contribute an end-to-end approach that automatically extracts an extensible timeline template from a bitmap image. Our approach adopts a deconstruction and reconstruction paradigm. At the deconstruction stage, we propose a multi-task deep neural network that simultaneously parses two kinds of information from a …

Review Of Comanche Jack Stilwell: Army Scout And Plainsman, By Clint E. Chambers And Paul H. Carlson, Thomas A. Britten

History Faculty Publications

The book’s primary aim is to provide a straightforward biography of Jack Stilwell (co-author Clint Chambers’s great-great-uncle) and to place his story within the context of western history during the last three decades of the nineteenth century. “Comanche Jack” left little written evidence behind for historians to peruse, but by diligently combing widely scattered army records, census rolls, court testimonies, and commentaries in newspapers and magazines, the authors succeed in providing both an interesting read and a balanced assessment of this rather remarkable individual.

The Mathematics Of The Astrolabe And Its History, Graziano Gentili, Luisa Simonutti, Daniele C. Struppa

Mathematics, Physics, and Computer Science Faculty Articles and Research

In this article we trace the scientific and cultural history of the astrolabe, a mechanical instrument used in the past for astronomical measurements and navigational purposes. The story of the astrolabe is interesting from several points of view, since it intertwines mathematical developments, geographical explorations, changing worldviews, and different cultures and civilizations. In our explorations we move from the early understanding of the world due to the Greeks, to the loss of their work, its rediscovery, the reception of Arab thinkers in Western natural philosophy, and, finally, to the new European culture that emerged with the end of the Middle …

Khirbat ‘Ataruz 2015: A Preliminary Report, Chang-Ho Ji, Robert D. Bates, Ralph K. Hawkins

Andrews University Seminary Studies (AUSS)

The biblical site of Ataroth mentioned in the book of Numbers was built by the Gadites and destroyed in the mid-9th century BC by king Mesha of Moab. The site contained a temple complex with a sanctuary and several altars. In 2015, a joint team from La Sierra, Andrews, Averett, and Brigham Young Universities continued excavation at the site. Their primary goal was to explore the north, south, and east edges of the temple complex to determine its full extent, its fortifications, and any domestic living spaces in the area. An outer wall was discovered on the southern side of …

A Review Of Minority Stress As A Risk Factor For Cognitive Decline In Lesbian, Gay, Bisexual, And Transgender (Lgbt) Elders, Anthony N. Correro, Kristy A. Nielson

Psychology Faculty Research and Publications

Lesbian, gay, bisexual, and transgender (LGBT) older adults comprise a unique and growing subset of the aging population. The historical context in which they came of age was imbued with victimization and discrimination. These experiences are subjectively stressful and collectively known as minority stress. Older LGBT adults continue to face stressors related to their gender and sexual identities in their daily lives. Importantly, chronic minority stress (CMS), like other forms of chronic stress, is harmful to health and well-being. CMS contributes to LGBT health disparities, including cardiovascular disease and depression, conditions that in turn increase risk for premature cognitive decline. …

Culturally Responsive Care For American Indians And Alaskan Natives: An Online Training Module For Occupational Therapists, Dayton Bender, Penelope Yoosook

Occupational Therapy Capstones

The unique profession of occupational therapy (OT) values cultural aspects when working with clients, therefore it is crucial for practitioners to be aware of various cultural backgrounds to provide greater culturally sensitive and client-centered services. The objective of this scholarly project was to create an educational opportunity for occupational therapists (OTs) who work in communities with a notable population of American Indian/Alaska Natives (AI/AN) through the use of an e-learning module designed to increase culturally competent care. Currently, there is limited literature suggesting the existence of such educational materials regarding this population, including online learning modules. This project was the …

Occupational Therapy Best Practice Addressing Anxiety-Related Behaviors: Extending Strategies Into The Classroom, Hannah Burks, Kristen Kilian-Weides

Occupational Therapy Capstones

The purpose of this project was to develop a product, created by occupational therapists, for teachers and support staff that offers behavioral management strategies for students demonstrating anxiety related behaviors in the classroom. Research conducted by Nash, Schlösser, and Scarr (2016) revealed that teachers reported feeling underprepared to not only identify anxiety presenting in the classroom, but also to manage these disruptive behaviors resulting from anxiety. Thus, the product, titled Tips for Teachers, was developed to address this need and to increase collaboration between occupational therapists, teachers, and support staff.

The hierarchical approach utilized in the current behavioral management system …

Exploring A Best-Practice Approach For Preventing Challenging Behavior In Pediatric Occupational Therapy, Mckenzie Ramsey Gehring, Kimberly Harmelink

Occupational Therapy Capstones

Purpose This scholarly project was created to provide pediatric occupational therapists with a best-practice approach to address challenging behavior by focusing on its prevention while establishing consistency throughout the clinic.

Methodology An extensive literature review was performed using eight search databases and combinations of six primary search terms as well as original works by key scholars and researchers. The results of this literature review suggested the need for a best-practice approach to both protect occupational therapists and their clients during interventions related to challenging behavior and to provide guidance as to how to format a consistent approach toward challenging behavior …

Hand Therapy Outcomes: Therapists’ Perceptions Of Occupation-Based Interventions In Practice, Cheyenne Hanson, Molly Maudal

Occupational Therapy Capstones

Purpose: It is well known that hand therapists frequently use biomechanical-based interventions in their treatment of upper extremity injuries and pathologies. There is a push to return to the occupational therapy profession’s roots of occupation-based practice, which has recently been further reinforced with the introduction of the American Occupational Therapy’s (AOTA) Choosing WiselyⓇ Initiative (Gillen et al., 2019). Hand therapy is one area in which occupation-based practice could become more prevalent. This study will enhance the existing research on occupation-based hand therapy through the use of focus group interviews with occupational therapists who have a majority of their caseload classified …

Farmer And Rancher Suicide: Raising Awareness, Noelle Rivard, Krista Steinbeisser

Occupational Therapy Capstones

Suicide is death caused by self-directed, injurious behavior with the intent to die (National Institute of Mental Health [NIMH], 2019). This is a concerning public health issue, as it is the 10^th leading cause of death in the United States (U.S.) (Hedegaard, Curtin, & Warner, 2018). Suicide rates vary between different populations, with the occupational group of Farming, Fishing, and Forestry having a disproportionately higher suicide rate than the national average (Jared, 2019; Peterson et al., 2018). Farmers and ranchers in rural regions of the U.S. are not receiving appropriate mental health services due to a shortage of health …

Electrochemical Detection Of Neurotransmitters, Saikat Banerjee, Stephanie Mccracken, Md Faruk Hossain, Gymama Slaughter

Bioelectrics Publications

Neurotransmitters are important chemical messengers in the nervous system that play a crucial role in physiological and physical health. Abnormal levels of neurotransmitters have been correlated with physical, psychotic, and neurodegenerative diseases such as Alzheimer's, Parkinson's, dementia, addiction, depression, and schizophrenia. Although multiple neurotechnological approaches have been reported in the literature, the detection and monitoring of neurotransmitters in the brain remains a challenge and continues to garner significant attention. Neurotechnology that provides high-throughput, as well as fast and specific quantification of target analytes in the brain, without negatively impacting the implanted region is highly desired for the monitoring of the …

Electrotransfer Of Il-15/Il-15rα Complex For The Treatment Of Established Melanoma, Shawna A. Shirley, Cathryn G. Lundberg, Richard Heller

Bioelectrics Publications

Gene electrotransfer (GET) is a safe, reliable, and effective method of delivering plasmid DNA (pDNA) to solid tumors. GET has been previously used to deliver interleukin-15 (IL-15) to mouse melanoma, resulting in long-term tumor regression and the survival of a percentage of treated animals after challenge. To enhance this effect, we evaluated modulating the expression levels of IL-15 and co-expressing its receptor, IL-15Rα. GET was used to deliver plasmids encoding IL-15 and IL-15Rα to established B16.F10 tumors on days 0, 4, and 7. Two delivery protocols that yielded different expression profiles were utilized. Mice that were tumor-free for 50 days …

Reevaluating Environmental Citizen Suits In Theory And Practice, David E. Adelman, Robert L. Glicksman

University of Colorado Law Review

Citizen suits are frequently cited as an essential legal innovation by virtue of their capacity to provide a backstop to lax or ideologically antagonistic administrations. Drawing on data from fifteen years of litigation under two prominent environmental statutes, we find little evidence that citizen suits effectively serve this role in practice. Instead, we find that limited resources and institutional barriers strictly limit the number of citizen suits filed annually against the federal government under two of the most litigated environmental statutes, the National Environmental Policy Act (NEPA) and the Endangered Species Act (ESA). While our findings do not negate the …

Contingent Delisting, Justin R. Pidot

University of Colorado Law Review

No abstract provided.

Ecosystem Services And Federal Public Lands: A Quiet Revolution In Natural Resources Management, J.B. Ruhl, James Salzman

University of Colorado Law Review

The major federal public land management agencies (the Forest Service, Bureau of Land Management, Park Service, Fish & Wildlife Service, and Department of Defense) have increasingly adopted a language that did not exist twentyfive years ago-the language of ecosystem services. Ecosystem services are the range of benefits that ecological resources provide to humans, from water purification and pollination to carbon sequestration and wildlife habitat. The scientific discipline advancing the ecosystem services framework arose in the mid-1990s and quickly became a central strategy for fusing ecology and economics research. Despite its ascendance in research communities, the recognition and conservation of ecosystem …

An Old View Of The Cathedral: Intellectual Property Under The Colorado Uniform Partnership Act, Nathaniel T. Vasquez

University of Colorado Law Review

The Colorado Uniform Partnership Act ("CUPA") contains a subtle shortcoming. CUPA is a default statute that only operates in the absence of a governing agreement between two partners formed at the outset of the partnership. As with most things in this life, partnerships inevitably come to an end. When this happens, a partner is said to have "dissociated" from the partnership. Typically, this is followed by a dissolution of the partnership itself

Rather than terminating at that point, the partnership then goes into what is called the "winding up" period. Among other things, winding up involves liquidating all of the …

Dustbowl Waters: Doctrinal And Legislative Solutions To Save The Ogallala Aquifer Before Both Time And Water Run Out, Warigia M. Bowman

University of Colorado Law Review

Eighty-three years after the Dust Bowl, residents of America's High Plains face a dire threat: their primary aquifer faces depletion, and entire sections of the country are set to run out of groundwater by the end of the century or sooner.

The Ogallala Aquifer provides a significant amount of America's agricultural irrigation water and is a primary source of drinking water for Colorado, Kansas, Nebraska, New Mexico, Oklahoma, South Dakota, Texas, and Wyoming.

This Article argues that policymakers should slow the Aquifer's depletion rate by implementing changes to irrigation technology, crop choice, consumer behavior, legal doctrine, and legislation. This Article …

Dynamic Expression Of Slit1-3 And Robo1-2 In The Mouse Peripheral Nervous System After Injury, Bing Chen, Lauren Carr, Xin-Peng Dun

Peninsula Medical School

The Slit family of axon guidance cues act as repulsive molecules for precise axon pathfinding and neuronal migration during nervous system development through interactions with specific Robo receptors. Although we previously reported that Slit1-3 and their receptors Robo1 and Robo2 are highly expressed in the adult mouse peripheral nervous system, how this expression changes after injury has not been well studied. Herein, we constructed a peripheral nerve injury mouse model by transecting the right sciatic nerve. At 14 days after injury, quantitative real-time polymerase chain reaction was used to detect mRNA expression of Slit1-3 and Robo1-2 in L4-5 spinal cord …

After The Fire: Post-Pandemic Reflections, Daniel Martin

Peninsula Medical School

Over the space of a few months virtually everything we know has been turned on its head. In Wuhan (China) during the closing months of 2019 a spillover event occurred in which the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was transferred from its animal host population into humans 1, 2. Spread mainly by respiratory droplets, the virus has a basic reproduction number (R0) of between 2-6 in an unprotected population making it more contagious than influenza, but considerably less so than measles. As SARS-CoV-2 rapidly spread across the planet, aided by our love of intercontinental travel, the local market …

Leadership In Dental Practice: A Three Stage Systematic Review And Narrative Synthesis, Sally Hanks, Lucy Spowart, Debby R.E. Cotton

Peninsula Medical School

No abstract provided.

Editorial: ‘Do We Really Need Another Review On The Effects Of Physical Activity On Alcohol And Other Drug Use Disorders?’, Adrian H. Taylor, Tom P. Thompson, Jane Horrell

Peninsula Medical School

No abstract provided.

Front Matter

Lewis & Clark Law Review

Front Matter contains Table of Contents, Masthead, and faculty for Lewis & Clark Law Review Volume 24, Issue 3.

Mother Nature, Lady Justice: Ecofeminism And Judicial Decision-Making, Jonathan Alexis Picado

Open Access Theses & Dissertations

Ecofeminism offers a feminist perspective that links gender to how humans relate to the natural world. As such, this framework explores the connections between the oppression of nature and the oppression of women, such as widespread views that both women and nature are property, are to be dominated, and are most valuable when cultivated and curated by men. I apply this philosophical and sociological framework to judicial decision-making, where women judges should view environmental issues as women's issues and thus be more likely to vote in favor of the environmental protections relative to her male peers. I evaluate this theory …

Soy Una Muñeca De Porcelana, Nicolas Rodriguez Sanabria

Open Access Theses & Dissertations

Tesis de maestrí­a de Creación Literaria

Utilizing Zircon (U-Th)/He And 40ar/39ar Thermochronology To Refine The Thermal History Of The Great Unconformity Within New Mexico And Colorado, Jacoup Roiz

Open Access Theses & Dissertations

The Great Unconformity beneath Paleozoic strata represents 100-1000 m.y. of missing rock record that formed through extensive weathering and erosion. Despite its global extent, the timing of Precambrian crystalline rock exhumation prior to Phanerozoic sediment deposition remains relatively unresolved in many locations. I utilized zircon (U-Th)/He (ZHe) thermochronology in order to constrain the long-term thermal history of Precambrian rocks in Colorado and New Mexico, and test my hypoThesis that these units below the Great Unconformity experienced multiple cooling and reheating episodes resulting in a compound surface representing multiple unconformities. In addition to a synThesis of previously reported data in the …

Partitioning Variation In Vegetation And Landscape Functionality In Arid Land Piosphere, Eahsan Shahriary

Open Access Theses & Dissertations

A piosphere is an interaction between vegetation community, watering point, and grazing livestock/wildlife. In this Dissertation, I begin by reviewing the concept of the piosphere, and the progress, knowledge gaps and common statistical approaches and errors in piosphere research. Landscape functionality, plant community distribution and their influencing factors on a piosphere in Iran are then investigated.

A total 862 piosphere publications of multiple types from 68 countries and 10 different languages during the period of 1915 â?? 2018 were reviewed. Australia was the most productive country followed by South Africa, the USA, Botswana and Argentina. Ivan Thrash is the most …