Digital Commons Network^™

Direct-To-Consumer Ads Are Misleading: Concise Statements Of Effectiveness Should Be Required, Robert A. Bohrer

Journal of Health Care Law and Policy

The issue of required disclaimers in direct-to-consumer (DTC) advertising of pharmaceuticals boiled to the surface in May 2019, when the Centers for Medicare and Medicaid Services (CMS) published a final rule requiring the disclosure of a drug’s price in DTC ads. The idea is not a new one––the American Medical Association (AMA) adopted a resolution recommending just such a required disclosure in June 2017. For a number of reasons, even if the proposal is implemented it may not have much effect. Consumers may see price as an indicator of effectiveness, just as a high-priced car is expected to be superior …

The Law Of The Tetrapods, Henry T. Greely

Vanderbilt Journal of Entertainment & Technology Law

Should there be such a thing as "Technology Law"? This Article explores that question in two ways. It first looks at four substantive issues that appear across many different areas of technology law: privacy, security, property, and responsibility. It then examines five questions that frequently recur about how to regulate very different new technologies. These questions include which agency should regulate, whether regulation should focus on before or after marketing, what jurisdiction should regulate, how relevant new information will be gained and used, and how-politically-good regulation can be enacted. This Article concludes that it may make sense to develop a …

Unh: The Magazine Of The University Of New Hampshire, Winter 2020, Unh Magazine

UNH Magazine

No abstract provided.

C-Molecules: Molecular-Guided Surgery With Fluorescence Imaging, Riley Karp, Joshua Gutow, William Wolfe-Mcguire

ENGS 89/90 Reports

Surgeries may cost lives if performed inadequately, which is why tools such as fluorescence guided surgery exist to improve surgical outcomes. Fluorescence guided surgery (FGS) is the practice of injecting patients with a fluorescent molecule that, in combination with highly sensitive cameras, allows surgeons to clearly identify complex biological structures. While beneficial in procedures such as endoscopy and gallbladder surgery, this technique is most notable for its role in complex cancer surgeries where misidentifying the boundaries of a tumor can have deadly consequences. Although FGS has the potential to revolutionize cancer treatment, highly sensitive imaging systems are necessary to identify …

Bse Biology, 2020-21, Arkansas State University - Jonesboro

Bachelor of Science and Education

No abstract provided.

Why Prison Dental Care Matters: Legal, Policy, And Practical Concerns, Anne S. Douds, Eilenn M. Ahlin, Nicholas S. Fiore, Nicholas J. Barrish

Public Policy Faculty Publications

Even when controlling for demographic characteristics, prisoners are far more likely than people in the general population to suffer from periodontal disease, to have unresolved oral health issues, to have decayed teeth, and/or to be missing teeth. Correlates of poor oral health, such as poor nutrition and smoking, are more prevalent among people of lower socioeconomic status, and this same population is at a higher risk than others for offending and incarceration. For some, prison is the only time in their adult lives when they will have seen a dentist. There are few free dental clinics in communities, regardless of …

University Of South Dakota Zero Waste Atlas Campus Assessment 2020, Post-Landfill Action Network

Sustainability & Environment Projects

In Summer of 2020, the University of South Dakota worked with the Post-Landfill Action Network (PLAN) to support Anna Moore, the Campus Recycling Coordinator and a graduate student in the Department of Sustainability & Environment, to conduct a holistic assessment of the campus’ waste management system. Anna used PLAN’s Zero Waste Atlas Program, a program designed to help campuses assess and streamline campus systems for materials management, to collect the information used to inform this report. This abridged report offers a snapshot of existing policy, programs, and infrastructure, illustrates ideal material flows throughout a campus, and proposes a few broad …

Global Legal Constraints: How The International System Fails Small-Scale Farmers And Agricultural Biodiversity, Harming Human And Planetary Health, And What To Do About It, Susan H. Bragdon

American University International Law Review

No abstract provided.

Non-Alcoholic Fatty Liver Disease And The Gut Microbiome: The Effects Of Gut Microbial Metabolites On Nafld Progression In A 2-Organ Human-On-A-Chip Model, Rachel H. Boone

Honors Undergraduate Theses

Using a novel, adipose-liver, two-organ, human-on-a-chip system, the metabolic disease non-alcoholic fatty liver disease was modeled. This model was then used to test the effects of the gut microbiome on NAFLD progression. Two products of the gut microbiome, Trimethylamine-n-oxide and butyrate, were selected as representatives of potentially harmful and potentially beneficial compounds. A dose response, adipocyte and hepatocyte monocultures controls, and HoaC systems were run for 14 days. Through this experimentation, it was found that a dysbiosis of the gut microbiome could be influencing NAFLD progression. Additionally, further development and discovery regarding adipose-liver systems was added to the ongoing conversation …

The Effect Of Using Crispr/Cas9 Treatment To Delete The Myostatin Protein In Vivo And In Vitro, Marco Cardone

Honors Undergraduate Theses

This thesis proposal shows the efficiency of different methods of Myostatin inhibition by using CRISPR/CAS9. With the data cataloged by this thesis, researchers will have a better understanding of what methods are better to achieve their goals. The data was collected by reading multiple scientific articles involving the usage of CRISPR/CAS9 to inhibit the Myostatin protein. The data collected from all the different studies were analyzed in the same categories. The experiment that used CRIPSR/CAS9 on in vitro specimens had a superior Myostatin inhibition overall, therefore presenting higher muscle mass. The method using CRISPR/CAS9 to inhibit the Myostatin in vivo …

Detection Of A Peptide Hormone - Somatostatin - Label-Free Split-Aptameric Probes, Charles A. Dowis

Honors Undergraduate Theses

Peptide hormones are important biomolecules that transduce downstream effects such as cell proliferation, regulation, and gene expression. Their levels have been upregulated in various disorders such as cancer, yet detection methods are lacking. We designed two split aptamer-based assays for the detection of a peptide hormone – Somatostatin (SST) – with different signal readouts: fluorescent readout based on light-up aptamers and the colorimetric readout of ABTS peroxidation from a G-quadruplex. We used an already selected split-aptamer –SSTA5–for SST for our designs and we had expected the developed detection systems to exhibit detection and quantification capabilities that would hopefully allow their …

Evaluating The Nutritional Status Of Peruvian Born Children, Chantelle Garcia Medina

Honors Undergraduate Theses

Background: Rural areas of Peru lack access to healthcare resources and poor nutritional knowledge of what should be given to their children throughout their growth and development. The majority of the rural areas rely on a high carbohydrate, moderate vegetable diet, and lacking a protein source. Lower protein intake can lead to problems of malnutrition and growth stunting. Families rarely have monetary resources to provide a protein at every meal for the entire family. There is also a lack of a clean water supply, free of parasites and helminths. Caregivers often rely on replenishing intake with other fluids high …

The Effect Of A Senolytic Drug On Messenger Rna And Micro Rna Expression In Perigonadal Adipose Tissue Of Young And Old Mice, Catalina Hernandez

Honors Undergraduate Theses

As we face an expanding elderly population and increased age-related chronic diseases, we must seek solutions that address interconnected problems. Dasatinib plus quercetin (D+Q), a novel combination drug, is a proposed solution to improve the health and longevity of aged individuals with minimal side effects, exceptional efficacy, and maximum convenience. In this experiment, intermittent D+Q treatment was completed on young and old mice. RNA was extracted from perigonadal adipose tissue and cDNA libraries of mRNA and miRNA were made. Real-time quantitative polymerase chain reaction was used to assess relative gene expression for mRNA and miRNA pertaining to cell senescence, inflammation, …

Nature Contentedness Through Nature's Affordances, Fatima Khan

Honors Undergraduate Theses

There have been many studies conducted in the realm of nature that look at explanations behind human beings’ tendency to revert to nature as a way to relieve themselves from the real world while giving them feelings of well-being and positive emotions for a place. This study aimed to explore how humans feel more presence while also using this information to explore a more nature-oriented environment and the influence this has on human behavior. The present study is determining whether engaging with affordances of nature increase an individuals’ sense of presence. It was hypothesized that individuals that spend more time …

Investigating Aggression In Huntington Disease, Chloe E. Larochelle

Honors Undergraduate Theses

Huntington Disease (HD) is a neurodegenerative disorder that is caused by a CAG trinucleotide repeat expansion in the huntingtin gene. The onset of the disease is defined by the presence of motor deficits, such as chorea. However, cognitive and psychiatric symptoms often develop before motor onset and typically have a larger impact on patient quality of life. Psychiatric symptoms include depression, anxiety, and OCD, but also aggression and irritability, which have been comparatively understudied due to stigma. Currently, treatments to modify these behaviors in premanifest HD patients are not consistently effective and often have side effects, creating a need for …

Using Children's Literature To Support Social And Emotional Learning In Third Through Sixth Grade Classrooms, Hayley L. Paljug

Honors Undergraduate Theses

This research examined the use of award-winning children’s literature for social and emotional learning, focusing on its use for children in third through sixth grades. The world is ever-changing, and, as a result, the need for children to learn necessary social and emotional skills continues to increase. These skills include, but are not limited to, perseverance, friendship, grit, caring, and the like. It has been found that teaching social and emotional skills through bibliotherapy is an engaging and successful method that can be used by schools and teachers. Teachers or other educational stakeholders can use this document to begin to …

Genetic Structure Of Green Sea Turtle (Chelonia Mydas) Foraging Aggregations On The East Coast Of Florida, Monica R. Reusche

Honors Undergraduate Theses

The genetic structure of juvenile green turtles (Chelonia mydas) foraging on the east coast of central Florida is not well understood, nor has it been examined over time. In the last three decades, the dramatic increase in the number of green sea turtle nests in Florida, in association with other population parameters, has led to this species being down-listed under the Endangered Species Act from “endangered” to “threatened” in the northwest Atlantic. However, it was unclear if the exponential growth in Florida nest numbers had any influence on the genetic structure of juveniles in nearby foraging aggregations. To …

Investigating The Effects Of Uv Filters In Sunscreen On Human And Environmental Health, Brittany M. Thompson

Honors Undergraduate Theses

Ultraviolet filters are active ingredients in sunscreen that protect us from harmful UV radiation. However, organic UV filters are thought to have adverse effects on the environment and humans. In recent years, fear of harmful impacts of sunscreen has caused a surge of coral reef safe sunscreens to hit the market. These sunscreens, which contain inorganic metal oxides as UV filters, have been accepted as safe for humans and the environment until recently. Metal oxides in reef safe sunscreens may form intermediates in the water that can harm marine life and can absorb through the skin and into the blood, …

Characterization Of The Physical And Chemical Effect Of Membrane Disruption And Protein Inhibiting Treatments On E. Coli, Khadijah Wright

Honors Undergraduate Theses

The increase in antibacterial resistance has placed the issue of microbial multi-drug resistance on a global stage (Gurunathan, 2019). This issue poses a threat to human and animal health as well as to the environment (Aslam et al., 2018). It affects not only the efficacy of treatment but also how those treatments are conducted (Friedman, Temkin, & Carmeli, 2016). As a result of this ongoing threat, new treatments that have potent effects on bacteria are necessary. One scientific response to this issue has been the development of multifunctional nanoparticles (NPs)(H. Wang et al., 2018). NPs have the ability to be …

Perceptions And Punishment Of Human-Animal Altercations, Adriana C. Mata Guidi

Honors Undergraduate Theses

Humans and animals have a widely varying relationship which has been studied at length. Examining our interactions with animals in negative contexts can help us further understand the factors that’s influence the nature of the human-animal relationship, particularly with our most popular companion animals. This study continues the use of a jury design, previously used in studies regarding animal abuse, to examine responses to a scenario of an altercation resulting in a dog biting a person. In this study, 243 undergraduate students read the scenario presented to them and completed a survey examining their judgements of blame and punishment for …

Exploring The Effects Service Dogs Have On Veterans With Ptsd, Shelby E. Reeves

Honors Undergraduate Theses

Post-Traumatic Stress Disorder (PTSD) is a mental illness resulting from exposure to a traumatic event. Symptoms of PTSD vary, but those affected commonly experience nightmares, flashbacks, hypervigilance, and trouble sleeping; they may also avoid people or situations that trigger traumatic memories. It is estimated that PTSD affects about 10-30% of all United States veterans. Additionally, traditional treatment methods have an average dropout rate of 25% among military personnel. Inadequate PTSD symptom management may lead to depression, anxiety, suicidality, isolation, unstable relationships, and substance misuse. The purpose of this review is to examine the current research concerning the use of service …

Physical Activity Moderates The Relationship Between Apoe4 Status And Working Memory: The Health And Retirement Study, Dalia T. El-Shafie

Honors Undergraduate Theses

The purpose of this study is to explore the relationship between physical activity and working memory decline among older adults with APOE4 status. The APOE4 allele is currently the strongest predictor of risk for Alzheimer's disease and other related dementias. The publicly available data from the Health and Retirement Study was used to complete this Retrospective Longitudinal study. Three hypotheses were explored. H₁: It is expected that the presence of the APOE4 allele will be associated with worse overall working memory performance and a steeper rate of decline in working memory over time. H₂: Meanwhile, it is expected that participants …

Sensing Symbiosis: Investigating The Symbiotic Magnetic Sensing Hypothesis In Fish Using Genomics, Elizabeth Boggs

Honors Undergraduate Theses

The mechanism behind magnetoreception – the ability to sense magnetic fields for orientation and navigation – still remains one of the most difficult questions to answer in sensory biology, with fish being just one of many taxa known to possess this sense. Characterizing a magnetic sense in fish is crucial for understanding how they navigate their environment and can inform on how increasing anthropogenic sources of electromagnetic fields in aquatic environments may affect threatened fish species. This study examined the hypothesis put forth by Natan and Vortman (2017) that magnetotactic bacteria (MTB), bacteria that create their own chains of magnetic …

Role Of Polyploidy In Leaf Functional Trait Evolution Across Wild Helianthus, Anestacia S. Robinson

Honors Undergraduate Theses

Whole genome duplication, or polyploidy, is a common process in plants by which failures in meiosis or fertilization result in offspring with twice the number of chromosomes. This doubles the number of copies of every gene, an effect thought to generate new ‘raw material' upon which natural selection can act. Few studies exist examining the consequences of polyploidy for plant physiological traits. Doubling the number of gene copies may have unknown effects on leaf structure and function. In this study, I compare diploid, tetraploid, and hexaploid species within the genus Helianthus (wild sunflowers). Forty different accessions of wild sunflowers were …

Promotion Of Neuronal Regeneration: Upregulation Of Intrinsic Neuronal Growth Capacity Versus Microtubule Stabilization, Cathy Le

Honors Undergraduate Theses

Central Nervous System (CNS) injury may lead to irreversible damage to cognitive and motor abilities when injured. This is due to the inability of axons to regenerate. This thesis focuses on two methods of promoting axonal regeneration: microtubule stabilization and upregulation of the intrinsic growth capacity of the neuron via the mechanistic target of rapamycin (mTOR) pathway. Both have shown promising results in potentially being a therapeutic treatment for CNS trauma. This research seeks to (1) test a combinatorial method of axonal regeneration utilizing both methods simultaneously and (2) compare microtubule stabilization and upregulation of the mTOR pathway as neuronal …

Left Ventricular Strains During Late Filling In A Preclinical Model, Saar Peles

Honors Undergraduate Theses

Understanding the mechanisms governing left ventricular function and dysfunction is critical to analyze cardiovascular disorders and gaining insights into possible therapies. Left ventricular function can be evaluated using Magnetic Resonance Imaging (MRI). Cardiac displacements and corresponding strains are then computed from the imaging data. In measuring and assessing the left ventricle’s motion, images are taken either in the short axis (top-down) or long axis (side) views. In this project, we will use DENSE MRI data, which measures the displacements of individual tissue voxels during the cardiac cycle.

After extracting the myocardial tissue by segmenting the MR images, strains are computed …

Systematic Literature Review Of Cognitive Behavioral Treatments For Patients With Classical, Secondary, And Idiopathic Trigeminal Neuralgia, Linnea B. Herzog

Honors Undergraduate Theses

Trigeminal neuralgia is a painful neuralgia with a complicated pathology that is not clearly understood. Due to the ambiguity of the condition, patients often have to search for medical providers that specialize in trigeminal neuralgia, and even with the guidance of a specialist, some patients do not respond well to treatment.¹ Despite the uncertainty surrounding the specifics of the disease, there are treatments available that can provide some level of pain relief for patients suffering from this disorder. When a patient does not respond well to medical therapy, surgery can be the next appropriate step in patient care management. …

Managing Invasive Plants On Great Plains Grasslands: A Discussion Of Current Challenges, John Gaskin, Erin Espeland, Casey D. Johnson, Jane M. Mangold, Rachel A. Mcgee, Chuck Milner, Shishir Paudel, Dean E. Pearson, Lora B. Perkins, Chadley W. Prosser, Justin B. Runyon, Sharlene E. Sing, Zachary A. Sylvain, Amy J. Symstad, Daniel R. Tekiela

Native Plant Focused Publications

The Great Plains of North America encompass approximately 1,300,000 km² of land from Texas to Saskatchewan. The integrity of these lands is under continual assault by long-established and newly-arrived invasive plant species, which can threaten native species and diminish land values and ecological goods and services by degrading desired grassland resources. The Great Plains are a mixture of privately and publicly owned lands, which leads to a patchwork of varying management goals and strategies for controlling invasive plants. Continually updated knowledge is required for efficient and effective management of threats posed by changing environments and invasive plants. Here we …

Kinder – 1st Grade: Summer Packet #3 • Theme: Community, Tricia Gray, Jessica Mitchell-Mccollough, Alexa Yunes-Koch

ICMEE Learning Packets: Level 1-2 of English Proficiency (K-5)

These packets are self-contained. Everything a child will need to be successful with the activities is provided in the packet. Students will only need a writing utensil. Additional tools like crayons or scissors can be used, but do not have to be.

Day 1 • My Buddy • Check the Weather • What will you wear? • Let’s Write! Color the pictures and trace the words. • Read the story What is a Family? • Let’s Count! • Journal • Let’s Move! Play Tic Tac Toe!

Day 2 • Check the Weather • What will you wear? • Vocabulary Review …

Office Of Professional Accountability Annual Report 2019, Tennessee. Department Of Safety & Homeland Security.

Miscellaneous Reports

No abstract provided.