Nuclear-Targeted Gold Nanoparticles Enhance The Effects Of Radiation Therapy With And Without Liposomal Delivery, Maureen Aliru

Dissertations and Theses (Open Access)

Less that 10% of pancreatic cancer patients are eligible for curative resection, and clinical trials evaluating chemoradiation in locally advanced patients with unresectable disease have been largely disappointing. New and creative therapeutic approaches are needed to address the unment need for treatment options. The objective of this thesis is to advance radiosensitization of treatment-resistant densely desmoplastic pancreatic cancer using nanoparticles to surmount biological barriers to effective particle distribution for DNA-targeting.

Clinical translation of radiosensitizing nanoparticles has stalled owing to technical challenges. Current strategies to use AuNPs for radiosensitization require large quantities of gold, kilovoltage x-rays, immediate irradiation after intravenous administration, …

The Role Of Daam1 In Kidney Development, Vanja Krneta-Stankic

Dissertations and Theses (Open Access)

Kidneys, like most organs in our bodies, consist of a network of epithelial tubules. Kidney tubules are called nephrons, and their morphology is important for kidney function. Nephrons develop from mesodermally derived aggregates of progenitor cells. The nephric progenitors organize into nephric tubules lined with hair-like sensory projections called cilia. Many diseases of the kidney are characterized by abnormal nephron morphology with current treatment aimed at symptom control. To understand the mechanisms underlying kidney diseases and achieve the development of novel therapies, a better understanding of how nephrons develop is needed. Although the actin cytoskeleton is critical for cell behaviors …

Qki-Mediated Cholesterol Biosynthesis In Eye Lens And Myelin Of The Central Nervous System, Seula Shin, Seula Shin

Dissertations and Theses (Open Access)

Cells obtain cholesterol in two ways, de novo biosynthesis and uptake from circulation. While most tissues utilize both sources, eye lens and brain depend extensively on cholesterol biosynthesis due to the limited supply from circulation. Lens cell membrane consists of highest portion of cholesterol. Brain is the most cholesterol-rich organ, which accounts for 23% of total cholesterol. Genetic mutations of cholesterol biosynthesis enzymes in humans and animal models present cataracts and hypomyelinating disorders linked to neurological impairment. Yet, it remains unclear how gene expression of cholesterol biosynthesis is regulated in lens and brain. Therefore, studying cholesterol biosynthesis in both tissues …

Fibroblast Heterogeneity In Pancreatic Cancer Immunity, Josephine Darpolor

Dissertations and Theses (Open Access)

Fibroblasts are a unique cell type defined by their mesenchymal phenotype and exclusion from epithelial, immune, and endothelial cell subsets. Although well studied in wound healing, cancer associated fibroblasts (CAFs) are incredibly heterogeneous, leading to contradictions as to the roles CAFs play in the tumor microenvironment (TME). CAFs were thought to be a barrier to treatment of pancreatic ductal adenocarcinoma (PDAC). However, general stromal targeting strategies have largely failed in the clinic likely due to the heterogeneity of CAFs in the TME. Therefore, our groups and others have worked to unravel the heterogeneity of CAFs in PDAC. In the works …

Qki-Mediated Cholesterol Biosynthesis In Eye Lens And Myelin Of The Central Nervous System, Seula Shin, Seula Shin

Dissertations and Theses (Open Access)

Cells obtain cholesterol in two ways, de novo biosynthesis and uptake from circulation. While most tissues utilize both sources, eye lens and brain depend extensively on cholesterol biosynthesis due to the limited supply from circulation. Lens cell membrane consists of highest portion of cholesterol. Brain is the most cholesterol-rich organ, which accounts for 23% of total cholesterol. Genetic mutations of cholesterol biosynthesis enzymes in humans and animal models present cataracts and hypomyelinating disorders linked to neurological impairment. Yet, it remains unclear how gene expression of cholesterol biosynthesis is regulated in lens and brain. Therefore, studying cholesterol biosynthesis in both tissues …

The Hunt For Loot: Proposed Solutions To More Effectively Regulate Addictive Gambling Mechanics In Video Games, Andrew Brewer

Journal of Law and Policy

Over the past decade, more and more video game developers have embraced “loot boxes” as a lucrative source of revenue. But recent concerns over the potential harms of loot boxes, particularly to children, have raised questions about their use and prompted attempts to regulate them throughout the world. This Note explores recent attempts—both foreign and domestic—to regulate loot boxes and proposes new solutions based on those strategies’ shortcomings. By carefully and competently defining terms and exceptions, and providing for more aggressive oversight of agency regulatory efforts, federally-crafted loot box legislation can more effectively protect children from predatory gambling mechanics in …

“A Climate Of Lawlessness”: Upholding A Government’S Affirmative Duty To Protect The Environment Using Deshaney’S Special Relationship Exception, Katherine G. Horner

Journal of Law and Policy

The Industrial Revolution introduced an era of exceptional technological advances. However, it also led to rampant environmental pollution and degradation. The proliferation of toxic pollutants in the air, water and soil has led us to the precipice of an unimaginable future; a future defined by climate change. This Note argues for the use of the special relationship exception, affirmed by the Supreme Court in DeShaney v. Winnebago, in environmental litigation in order to uphold governments’ affirmative duty to protect the environment. As federal and state governments have the sole power to regulate environmental pollution and enforce environmental protections, individuals are …

The Wicked Problem Of Zoning, Christopher Serkin

Vanderbilt Law School Faculty Publications

Zoning is the quintessential wicked problem. Professors Rittel and Webber, writing in the 1970s, identified as “wicked” those problems that technocratic expertise cannot necessarily solve. Wicked problems arise when the very definition of the problem is contested and outcomes are not measured by “right and wrong” but rather by messier contests between winners and losers. This accurately characterizes the state of zoning and land use today.

Zoning is under vigorous and sustained attack from all sides. Conservatives have long decried regulatory interference with private development rights. More recently, progressive housing advocates have begun to criticize zoning for making thriving cities …

Designing Law To Enable Adaptive Governance Of Modern Wicked Problems, J. B. Ruhl, Barbara A. Cosens A. Cosens, Niko Soininen, Lance Gunderson

Vanderbilt Law School Faculty Publications

This Article contributes to the development of adaptive governance theory by articulating and situating the role of formal law and government as the facilitator, but not central controller, of adaptive governance. To advance the understanding of adaptive governance, we argue that it can be understood in the broader context of scholarship covering the observed emergence of new governance, the efforts to develop theoretical understandings through decentered theory, and the refinement of constitutional understanding through democratic experimentalism. Synthesis of these three themes in turn informs the role of law and government in working with emergent governance responses to complexity to manage …

Conventional And Molecular Characterization Of Sheep Poxvirus (Spv) In Dakahlia Governorate, Egypt, Hagar Ghander, Mohamed El-Tholoth, Sahar Abd-El Rahman, Ali El-Kenawy

Mansoura Veterinary Medical Journal

Objective: Isolation, conventional and molecular characterization of sheep poxvirus (SPV) from clinically diseased vaccinated sheep in Dakahlia Governorate, Egypt. Design: Descriptive study. Samples: Forty samples including 20 skin nodules and 20 from lung, liver, lymph node and tongue (5samples from each) were collected from sheep flock consisted of 25 adult and 5 lambs. Procedures: The suspected virus was isolated through embryonated chicken eggs (ECEs). SPV was detected by agar gel precipitation test (AGPT), indirect fluorescence antibody test (IFAT) and histopathology in field and egg passaged samples. Ten samples were selected for molecular characterization by conventional and real time polymerase chain …

Genotypic And Phenotypic Characterization, Antibiotic Resistance And Virulence Patterns Of Staphylococcus Aureus Isolated Form Goat Mastitis, Yasser Kamel

Mansoura Veterinary Medical Journal

Objective: To determine the phenotypic and genotypic characterization of the virulence and antimicrobial susceptibility of S. aureus. Design: Descriptive study Samples:175 raw goat milk samples Procedures: A total of 87 S. aureus strains was isolated from goat with mastitis in north-west cost of Egypt. PCR technique was used to detect genes coding some virulence and antimicrobial properties while phenotypic antimicrobial susceptibility was determined by the disc diffusion method. Results: Most S. aureus isolates were resistant to amoxycillin (89.7%), penicillin G (88.5%), and ampicillin (86%) while were less resistant to other members of β-lactam group as cefoxitin (17.2%) and ceftriaxone (10.3%).The …

Predicting Personality Type From Writing Style, Tanay Gottigundala

Master's Theses

The study of personality types gained traction in the early 20th century, when Carl Jung's theory of psychological types attempted to categorize individual differences into the first modern personality typology. Iterating on Jung's theories, the Myers-Briggs Type Indicator (MBTI) tried to categorize each individual into one of sixteen types, with the theory that an individual's personality type manifests in virtually all aspects of their life. This study explores the relationship between an individual's MBTI type and various aspects of their writing style. Using a MBTI-labeled dataset of user posts on a personality forum, three ensemble classifiers were created to predict …

Comparison Of Combined/Carvedilol Moderate Dose Atorvastatin To Single High Dose Atorvastatin For The Prevention Of Contrast-Induced Nephropathy After Cardiac Catheterization, Rabab Ahmed El-Gazara, Maggie M. Abbassi, Nirmeen A. Sabry, Mohamed Seleem Mohamed, Soad Zakaria

Bulletin of Faculty of Pharmacy Cairo University

Background: Contrast-induced nephropathy (CIN) is associated with increased morbidity, and the need for short-term hemodialysis. Although several preventive measures have been used, the best approach to prevent CIN is still controversial. Objectives: This study is intended to evaluate the protective effect of carvedilol/ medium dose statin compared to the recommended high dose atorvastatin on the development CIN in patients undergoing elective cardiac catheterization (CC). Methods: A total of 144 patients planned for CC were randomly assigned to: • Group (A): 49 patients received atorvastatin as single high dose 80 mg 12 hours before CC and another 40 mg of atorvastatin …

Nonlinear Modeling And Control Of Driving Interfaces And Continuum Robots For System Performance Gains, Chengshi Wang

All Dissertations

With the rise of (semi)autonomous vehicles and continuum robotics technology and applications, there has been an increasing interest in controller and haptic interface designs. The presence of nonlinearities in the vehicle dynamics is the main challenge in the selection of control algorithms for real-time regulation and tracking of (semi)autonomous vehicles. Moreover, control of continuum structures with infinite dimensions proves to be difficult due to their complex dynamics plus the soft and flexible nature of the manipulator body. The trajectory tracking and control of automobile and robotic systems requires control algorithms that can effectively deal with the nonlinearities of the system …

Encystation And Glycogen Metabolism In Entamoeba Histolytica, Jordan Lynne Wesel

All Dissertations

Entamoeba histolytica is a parasitic protozoan that causes amebic dysentery, which affects approximately 90 million people annually, killing between 50-100,000. E. histolytica is transmitted via the oral-fecal route, through ingestion of contaminated food and water. The infectious form of the disease is the quiescent cyst, which after ingestion, undergoes excystation in the small intestine to the proliferative trophozoite. The trophozoite is the disease-causing form of the parasite, which colonizes the large intestine. Some trophozoites encyst in the large intestine and are passed out of the host, propagating the infectious cycle.

Despite the global burden of this disease, study of the …

Evaluating Drivers’ Understanding Of Automotive Symbols Related To Powertrain And Advanced Driver Assistant Systems, Breno Schwambach Costa

All Dissertations

The purpose of this research was to evaluate drivers’ understanding of automotive symbols meaning and what action to take in response to a symbol. With the dramatic increase in vehicle technology, the availability of a wide range of powertrain options, and the development of advanced driver assistant systems (ADAS), instrument cluster interfaces have become more complex, increasing the demand on drivers. Understanding the needs and preferences of a diverse group of drivers is essential for the development of digital instrument cluster interfaces that improve driver’s understanding of critical information about the vehicle. This research was divided in three studies. Study …

Examining Pathogenesis And Preventatives In Spontaneous And Staphylococcus-Induced Bacterial Chondronecrosis With Osteomyelitis In Broilers, Nnamdi Simon Ekesi

Graduate Theses and Dissertations

Bacterial chondronecrosis with osteomyelitis is the most important cause of lameness in broilers. This is important to poultry production, as it poses animal welfare issues, and causes a significant loss in revenue. The remediation of this disease requires the study of its etiology with fitting models and evaluating preventatives. The research reported herein covers genomic virulence analysis of BCO isolates, mainly Staphylococcus aureus, and Escherichia coli retrieved from lame birds. We found that S. aureus isolates were closest to chicken strains in Europe but may have been in the Arkansas area for a decade. Phylogenomics suggest our S. aureus is …

Optimization Of In-Vessel Food Waste Composting: Enzyme Activity And Microbial Dynamics, Ayawovi Selom Ametepe

Graduate Theses and Dissertations

A series of greenhouse-based, rotary-drum bioreactor experiments was designed to study microbial dynamics and enzyme activity during optimization of food waste composting. This work aims to optimize food waste composting by defining the best food waste-to-bulking agent proportion controlling conditions and by evaluating the food waste composting process when inoculated by a bacterial inoculant product compared to uninoculated compost. Three experiments were run in total. The two first experiments were conducted for 48 days with sampling at each step of composting, while the third experiment last 50 days and included one extra sampling date. In the first experiment, 50:50, 65:35 …

Zoning Cyberspace: Protecting Privacy In The Digital Upside Down, Raymond H. Brescia

Utah Law Review

Over fifty years ago, Charles Reich posited that we should extend property protections to what he would call “government largess”: that array of interests—from licenses to welfare benefits—that often form the bases for one’s economic existence in the modern world. Reich considered such protections essential to the preservation of individual autonomy, the independence that is critical to a functioning democracy. Today, our most personal information and even our thoughts, as reflected in our online activities and digital existence, are subject to “private largess.” Private entities possess information central to the identity of those individuals who utilize their services. This information …

Full Issue, Vol. 12

Monographs of the Western North American Naturalist

No abstract provided.

Checklist Of The Vascular Flora Of The Kaibab Plateau, Coconino County, Arizona, Glenn R. Rink, Wendy Hodgson, Barbara Goodrich Phillips

Monographs of the Western North American Naturalist

Seven hundred and ninety-two vascular plant taxa were documented for the Kaibab Plateau through a review of herbarium records (primarily online) and targeted fieldwork focusing on springs, natural ponds, cattle tanks, and sinkholes. Taxa not previously published or currently recorded on SEINet for the Kaibab Plateau include 7 taxa for Grand Canyon National Park, 4 taxa for the Kaibab National Forest, 51 taxa for the Kaibab Plateau, 6 taxa for Coconino County, and 5 taxa for the state of Arizona. Two hundred and thirty previously published records or records on SEINet were eliminated from the flora area by reviewing specimens …

Policing Farm Crime: An Exploratory Study Of Agricultural Crime Units, Brianna Lynn

Electronic Theses and Dissertations

The purpose of this study was to explore the practices, perceptions, and operations of agricultural crime units. To date, there has been little research conducted on policing agricultural crimes and no known research on units specializing in investigating them. The study utilizes data gathered from qualitative interviews with agricultural crime investigators across several states to fill this gap in the literature. The results allow for an examination of the fundamental practices of agricultural units, their perceptions and their experiences. In addition, they point to several implications for both policy and practice that may serve to guide our efforts to combat …

It Must Have Been Your Eyes, Christian Vasquez

Theses and Dissertations

This fiction book entails the story of a Mexican orphan girl, Mariana, who is propelled on to a journey to the U.S. along with her mysterious ability to see the future in people’s eyes. Her plight lands her on a shelter for unaccompanied immigrant children in Texas where she is forced to confront her fears and grow. In this surreal story that is based on true events, our times are reflected and even our future

Influence Of Burning And Grazing Management Practices On Subirrigated Sandhill Meadow Hay Production, Tara M. Harms

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Subirrigated meadows are a valuable forage resource to Sandhills ranching operations being used for hay production, grazing, or a combination of both. Practices that sustain meadow productivity should be encouraged to ensure a consistent feed supply for cattle. The potential influence of prescribed burning or pre-freeze and post-freeze grazing on forage production and quality are not well understood on these meadows. In grasslands, including meadows, excess dead plant material can accumulate, causing a potential reduction in forage yield and quality. Results of our three-year field study suggest that burning meadows in the spring is a suitable management option to remove …

Hitting The Trail: An Exploration Of An Outdoor Educational Experience At Intermountain West Junior High School, David N. Joy

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Outdoor educational experiences are one of the ways that young people learn about and experience the benefits that are found in the outdoors. However, despite the benefits that outdoor educational experiences have to offer, many young people do not participate for one reason or another. These reasons are often rooted in issues of social injustice. This study adds to about how outdoor educational experiences effect the perceptions of and attitudes toward the outdoors and learning in the outdoors, as well as what may be keeping so many people from participating in these experiences. One junior high school in the intermountain …

“Fetch M’Dear”: Healers, Midwives, Witches, And Conjuring Women In Select Ya And Toni Morrison Novels, Diane Mallett-Birkitt

Electronic Theses and Dissertations

Accusations and persecution of witchcraft have been embedded in global culture for centuries. For as long as these persecutions have occurred, women have found themselves accused most frequently. Older women with herbal knowledge were often called on to assist with childbirth or termination of pregnancies and this “secret knowledge” often led them to be suspected of supernatural abilities, often of a satanic nature. Intrigued by these wise women who appeared to have mysterious powers and a penchant for arousing the ire of men in the legal, medical, and religious communities, I began to notice their frequent appearance in novels. Does …

Prevention Of Chronic Inflammation By Targeting Macrophage Integrin Adb2, Cady Forgey

Electronic Theses and Dissertations

Macrophage integrin a_Db₂ promotes macrophage retention and accumulation within inflamed tissue, a key event in development of chronic inflammation. Recently, the P5 peptide was identified as a specific inhibitor for integrin a_Db₂ interaction with 2-(ω-carboxyethyl) pyrole (CEP), a ligand at inflammatory sites. This thesis aims to identify integrin a_D I-domain amino acids involved in binding P5 peptide and likewise to CEP. We propose that non-conserved, basic amino acids of the integrin a_Db₂ I-domain are responsible for binding to P5 peptide and likewise to CEP. Eight amino acids were analyzed by …

Climate Change Is Likely To Increase The Development Rate Of Anthelmintic Resistance In Equine Cyathostomins In New Zealand, Christian W. Sauermann, Dave M. Leathwick, Mark Lieffering, Martin K. Nielsen

Maxwell H. Gluck Equine Research Center Faculty Publications

Climate change is likely to influence livestock production by increasing the prevalence of diseases, including parasites. The traditional practice of controlling nematodes in livestock by the application of anthelmintics is, however, increasingly compromised by the development of resistance to these drugs in parasite populations. This study used a previously developed simulation model of the entire equine cyathostomin lifecycle to investigate the effect a changing climate would have on the development of anthelmintic resistance. Climate data from six General Circulation Models based on four different Representative Concentration Pathways was available for three New Zealand locations. These projections were used to estimate …

Effects Of Hand Preference On Digit Lengths And Digit Ratios Among Children And Adults, Sanjay Kumar, Maharaj Singh, Martin Voracek

Mathematical and Statistical Science Faculty Research and Publications

Background

Prenatal sex hormones may not exclusively determine effects of hand preference on digit ratios. Genetic determination is an alternative possibility.

Aim

To study the likelihood of similar effects of hand preference on digit lengths and digit ratios.

Methods

We selected similar numbers of left-handers and right-handers in samples of kindergarten children (N = 101, age range: 3.5–7 years) and adults (N = 189, age range: 17–28 years) and measured digit lengths (excluding the thumb) directly on the palmar hand.

Results

Compared to right-handers, left-handers had longer digits and lower third-to-fourth (3D:4D) digit ratios among children, whereas an …

Technology Aiding In Neonatal Lung Developmental Care, Megan Kirk

Undergraduate Honors Theses

In this paper, old as well as new technological findings to decrease premature infant mortality are reviewed. This paper discusses fetal development throughout pregnancy from conception to full-term status as well as fetal lung development specifically from conception until full-term status. Several ideas to rapidly develop and mature fetal lungs are discussed such as mothers ingesting artificial surfactant supplements, either independently or coupled with antenatal corticosteroids, as well as intra-amniotic instillation prior to 28 weeks gestational. Drawbacks regarding these two are mentioned as well such as the fetus’s lungs not being mature enough to use the artificial surfactant leading into …