Digital Commons Network^™

The Super Wicked Problem Of Donald Trump, Richard J. Lazarus

Vanderbilt Law Review

In 2009 I published a law review article that both explained why I believed that climate change was a “super wicked” problem for lawmakers and offered specific recommendations for ways that any laws addressing climate change should be crafted in light of its super wicked nature. The purpose of this subsequent Article is to revisit, modify, and update my earlier analysis based on the actual events of the past decade. Such hindsight analysis necessarily requires acknowledging, a bit embarrassingly, the things that I got wrong. Though, in my partial (not complete!) defense, I am in good company given the wholly …

The Wicked Problem Of Zoning, Christopher Serkin

Vanderbilt Law Review

Zoning is the quintessential wicked problem. Professors Rittel and Webber, writing in the 1970s, identified as “wicked” those problems that technocratic expertise cannot necessarily solve. Wicked problems arise when the very definition of the problem is contested and outcomes are not measured by “right and wrong” but rather by messier contests between winners and losers. This accurately characterizes the state of zoning and land use today.

Zoning is under vigorous and sustained attack from all sides. Conservatives have long decried regulatory interference with private development rights.More recently, progressive housing advocates have begun to criticize zoning for making thriving cities unaffordable …

Local Offenses, Brenner M. Fissell

Fordham Law Review

Criminal law is generally thought to exist within two jurisdictional levels: federal and state. Neglected in the legal mind, and in legal scholarship, is the vast body of criminal law promulgated by local governments. While one should ask “what” is being criminalized by cities, towns, and villages, one should also ask “how” these offenses are written. The offense-drafting practices reflected in state criminal law have been extensively studied, but this has never been attempted for local offenses. This Article undertakes that task. After surveying a large number of local criminal codes, this Article concludes that local offenses routinely fail to …

Artificial Intelligence For Social Impact: Learning And Planning In The Data-To-Deployment Pipeline, Andrew Perrault, Fei Fang, Arunesh Sinha, Milind Tambe

Research Collection School Of Computing and Information Systems

With the maturing of artificial intelligence (AI) and multiagent systems research, we have a tremendous opportunity to direct these advances toward addressing complex societal problems. In pursuit of this goal of AI for social impact, we as AI researchers must go beyond improvements in computational methodology; it is important to step out in the field to demonstrate social impact. To this end, we focus on the problems of public safety and security, wildlife conservation, and public health in low-resource communities, and present research advances in multiagent systems to address one key cross-cutting challenge: how to effectively deploy our limited intervention …

Polymer-Based Capacitive Gas Sensor For Machine Olfaction, Mohamed Fathy Hassan

Theses and Dissertations

Transferring human abilities and knowledge to machines has been the focus of decades of work by scientists and engineers. With the progress in computation power and algorithms such as artificial neural networks, machines have surpassed humans in complicated games like chess and the Chinese game Go. Some senses can be mimicked including touch, with pressure sensors, hearing, with microphones, and vision with charged couple device (CCD)imaging chips. Yet, relatively little progress has been made with the senses of smell and taste. Machine olfaction, the ability to detect and quantify vapors in the environment, poses a range of challenges, which if …

Improving Long-Term Vascular Graft Viability Using Peritoneal Pre-Implantation And Epsin-Mimetic Peptides, Mahyar Sameti

Theses and Dissertations

The primary goal of this project was to produce and develop a tissue-engineered small-diameter vascular graft which can replace the arteries and function well for long-term grafting. Implanting an electrospun tubular conduit into the peritoneal cavity to recruit autologous cells prior to grafting the conduit into the artery is a method to achieve this goal. Incorporating an epsin-mimetic peptide on the conduit prior to grafting is another proposed method to reach the goal. This will be accomplished through four complementary studies: (1) determining the effect of a pouch in peritoneal pre-implantation and reducing the potential peritoneal adhesion formation;(2) determining the …

Framework For Reasoning With Speech Processing, Ahmed Laarfi

Theses and Dissertations

It is known that programming languages are textual. We try here to take the advantages of Speech Recognition (SR) and employ them in creating a verbal Language, which takes its instruction from the voice. Because this work is a novel approach in the programming world, we could not find any resources. This dissertation aims to make essential developments in Speech Recognition (SR)and Artificial Intelligence by constructing a new compiler that receives commands verbally and executes them. That means entering data into the Computer by voice commands. This method of input means that we link several major computer topics with several …

Development Of Nirs Based Noninvasive Cerebrovascular Regulation Assessment, Stephanie Marie Miller

Theses and Dissertations

Alterations to cerebral blood flow (CBF) have been implicated in diverse neurological conditions, including mild traumatic brain injury, microgravity induced intracranial pressure (ICP) and intraocular pressure (IOP) increases, and mild cognitive impairment. Near infrared spectroscopy (NIRS)-measured regional cerebral tissue oxygen saturation (rSO2) provides an estimate of oxygenation of the interrogated cerebral volume that is useful in identifying trends and changes in oxygen supply to cerebral tissue and has been used to monitor cerebrovascular function during surgery and ventilation. In this study, CO2-inhalation-based hypercapnic breathing challenges were used as a tool to simulate CBF dysregulation, and NIRS was used to monitor …

December 2020 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Using Data Visualization To Demonstrate Outcomes—Examples From Ripple Effects Mapping, Clea Rome, Debra Hansen, Rebecca Sero, Lorie Higgins

Journal of Extension

If you have conducted a ripple effects mapping (REM) event, you may have wondered "What is the best way to use these data, and what are some creative options for sharing the findings?" REM involves a mind mapping approach to evaluation and is an effective way to collect qualitative data that document the direct and indirect impacts of complex programs and projects. We provide examples of visual ways to display the gathered data and describe how to use the information to elevate your program outcomes.

Mermaids Vs. Humans: Reality In Fantasy, Avery M. Powers

Senior Honors Theses

This thesis analyses how fantasy literature relates to and transforms concrete perceptions of reality, tracing its origins from mythic creation epics and the qualities that it shares with scripture. Overall, I propose a more imaginative approach to realistic literature that draws from the truths found in fantasy literature and by discussing fantasy literature and genre.

The creative element of this project includes an excerpt from an original children's fantasy novel. In it, I compare mythical characters with human characters and an imaginary world to the real world as it is experienced by characters from both worlds. The fantastical reality attempts …

Hunting Contests In New York State, Tyler Caffrey

Honors College Theses

The world is currently in a biodiversity crisis and hunting contests cannot continue. Hunting contests are not legitimate wildlife management tools, but exist for entertainment and killing for a prize. Many of the species targeted can be killed without bag limits. Additionally, many wildlife management practices are retroactive, meaning they are in response to an issue. Within New York State, these contests are not regulated by the NYSDEC beyond adhering to hunting regulations. With these factors together, animals targeted by these contests can be hunted to a detrimental point, and then management agencies would step in. These contests face significant …

Running And Physical Activity In An Air-Polluted Environment: The Biomechanical And Musculoskeletal Protocol For A Prospective Cohort Study 4haie (Healthy Aging In Industrial Environment—Program 4), Daniel Jandacka, Jaroslav Uchytil, David Zahradnik, Roman Farana, Dominik Vilimek, Jiri Skypala, Jan Urbaczka, Jan Plesek, Adam Motyka, Denisa Blaschova, Gabriela Beinhauerova, Marketa Rygelova, Pavel Brtva, Klara Balazova, Veronika Horka, Jan Malus, Julia Freedman Silvernail, Gareth Irwin, Miika T. Nieminen, Victor Casula, Vladimir Juras, Milos Golian, Steriani Elavsky, Lenka Knapova, Radim Sram, Joseph Hamill

Kinesiology and Nutrition Sciences Faculty Research

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Far too little attention has been paid to health effects of air pollution and physical (in)activity on musculoskeletal health. The purpose of the Healthy aging in industrial environment study (4HAIE) is to investigate the potential impact of physical activity in highly polluted air on musculoskeletal health. A total of 1500 active runners and inactive controls aged 18–65 will be recruited. The sample will be recruited using quota sampling based on location (the most air-polluted region in EU and a control region), age, sex, and activity status. Participants will complete online questionnaires …

Entry-Level Workplace Competencies Needed By Graduates Of A Community College Agriculture Program: A Midwest Case Study Using The Delphi Technique, Blake Colclasure

Journal of Research in Technical Careers

Community colleges have a strong history of providing vocational education and occupational training to meet changing workforce demands of local industries. In the Midwest, agricultural industries have expressed an expanding need for middle-skilled workers with postsecondary, prebaccalaureate credentials. The 21st century agricultural landscape has changed as a result of the need for efficiency and sustainability, and resulting emergent agricultural technologies. Community colleges will be integral to establishing a qualified agriculture workforce for entry-level, middle-skilled positions. This study utilized a modified Delphi approach to identify entry-level workplace competencies needed by graduates of a community college agriculture program. Delphi panel experts represented …

Investigating The Psychological Impact Of Covid-19 Among Healthcare Workers: A Meta-Analysis, Kavita Batra, Tejinder Pal Singh, Manoj Sharma, Ravi Batra, Nena Schvaneveldt

Environmental & Global Health Faculty Research

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Previous meta-analyses were conducted during the initial phases of the COVID-19 pandemic, which utilized a smaller pool of data. The current meta-analysis aims to provide additional (and updated) evidence related to the psychological impact among healthcare workers. The search strategy was developed by a medical librarian and bibliographical databases, including Medline, Embase, CINAHL, PsycINFO, and Scopus were searched for studies examining the impact of the COVID-19 pandemic on the psychological health of healthcare workers. Articles were screened by three reviewers. Heterogeneity among studies was assessed by I2 statistic. The random-effects model …

Narrowing Attainment And Achievement Gaps Of African American Third Grade Students Through Culturally Responsive Teaching, Phyteria Proctor, Phyteria Lashawn Proctor

Dissertations

Literature suggest culturally responsive teaching is one of our most powerful tools for accelerating student learning and helping students find their way out of the gap. Billions of dollars have been invested in creating educational equity, but the data have shown that inequality in achievement still exists. However, school districts are beginning to focus more on being aware of and sensitive to the cultural and social needs of African American students. When school communities accept the challenge of changing the culture within their schools to ensure all students reach their full potential, then the achievement gap can be eradicated.

The …

Understanding Grief In Adults Whose Sibling Died During Childhood: A Qualitative Study, Amanda Marie Mccarthy

Graduate Theses/Dissertations

This retrospective, phenomenological study investigated how bereaved siblings believe the death of their brother impacted their development. Through semi-structured interviews, five adults whose brother died during their adolescence discussed how their grief changed over time and the factors that influenced changes in grief. Participants experienced periods of lack of acceptance, independence and isolation, and finding contentment. Factors that influenced changes in grief include sibling’s cause of death, family reaction, establishment of a support network, remembering the deceased, and milestones and dates. These findings provide a glimpse into how grief changes over time in the context of development. Furthermore, the results …

An Examination Of Meat Consumption As A Pro-Environmental Behavior And Its Weak Correlation To Delay Discounting, Sarah Parkinson

Theses

This study presented meat consumption as an environmentally relevant behavior (ERB) and examined how the delay to an environmental loss might affect peoples’ decisions to eat meat. Participants completed a delay discounting survey where they selected what percentage of meat they would eliminate from their diet based on varying delays to rising sea levels flooding of their neighborhood. After watching a brief educational video, participants completed the survey a second time to examine whether the video had any influence on discounting rates in the post-survey. Participants also completed the 27-Item Monetary Choice Questionnaire (MCQ; Kirby & Marakovic, 1996) in order …

The Effect Of Nutritional Programming On Gut Microbiota In Broodstock And Progeny Fish, Samuel Patula

Theses

Aquaculture is currently the fastest growing animal production sector. Because the aquaculture sector is growing at rapid rates, certain materials for feed, specifically marine protein sources, are becoming increasingly expensive and unsustainable. To counteract the reliance on fishmeal (FM) and other marine protein sources in the industry plant protein (PP), specifically soybean meal (SBM), has been investigated to replace FM as a protein source. Unfortunately, SBM when given in high quantities (greater than 30%) has been shown to negatively affect fish performance including retarded growth, intestinal inflammation, reduction of spawn quality, as well as dysbiosis in the gut microbiome, most …

Efficacy Of The Nutritional Supplement, Evenflo, In The Management Of Sickle Cell Disease: A Randomized Controlled Trial, Richard Muga, Arthur Ajwang, James Ouma, Josephine Ojigo, Juliana Otieno, Peter Okoth, Caroline Wafula, Sophia Ajwang, David Ogolla, Abraham Hollist, James Adefisoye

Nursing & Health Sciences Research Journal

Background: In this study, we investigated if a combination of the nutraceutical supplement, EvenFlo and folic acid will be superior to the standard stand-alone use of folic acid.

Methods: We conducted a randomized double-blind, active-controlled, clinical trial. A total of 70 subjects with SCD ages 5-12 years were enrolled into the study with 35 in the intervention group and 35 in the control group; 61 completed the trial (32 from the intervention group and 29 from the control group).

Results: Participants in the intervention group were significantly less likely to experience crises compared to subjects in the control group. None …

Inducible Epithelial Resistance Against Acute Viral Pneumonia And Chronic Asthma, Shradha Wali

Dissertations and Theses (Open Access)

Viral pneumonia remains a global health threat despite worldwide vaccination and therapeutic programs. The influenza pandemic of 1918 and SARS-CoV2 pandemic of 2019-2020 are cautionary reminders demanding the need for novel treatment strategies. Moreover, in addition to causing acute disease, respiratory virus infections are often complicated by chronic lung pathologies, such as asthma induction, progression, and exacerbation. We have reported that mice treated with a combination of inhaled Toll-like receptor (TLR) 2/6 and TLR 9 agonists (Pam2-ODN) to stimulate innate immunity are broadly protected against respiratory pathogens, but the mechanisms underlying this protection remain incompletely elucidated. Here, we show in …

Hyperpolarized Carbon-13 Magnetic Resonance Measurements Of Tissue Perfusion And Metabolism, Keith Michel

Dissertations and Theses (Open Access)

Hyperpolarized Magnetic Resonance Imaging (HP MRI) is an emerging modality that enables non-invasive interrogation of cells and tissues with unprecedented biochemical detail. This technology provides rapid imaging measurements of the activity of a small quantity of molecules with a strongly polarized nuclear magnetic moment. This polarization is created in a polarizer separate from the imaging magnet, and decays continuously towards a non-detectable thermal equilibrium once the imaging agent is removed from the polarizer and administered by intravenous injection. Specialized imaging strategies are therefore needed to extract as much information as possible from the HP signal during its limited lifetime.

In …

Reversal Of Neurodegeneration By Engineered Monocytes In Alzheimer’S Disease, Chao-Hsien Chen

Dissertations and Theses (Open Access)

The health challenges posed by Alzheimer’s disease (AD) continue to grow as societies age worldwide. Accumulation of Tau-associated pathology correlates with clinical cognitive deterioration in AD. Resident myeloid cells within the central nervous system (CNS) have a limited capacity to uptake and degrade Tau; however, the resulting secretion of proinflammatory cytokines only acts to accelerate neurodegeneration. Therapeutic antibodies can reduce the neurotoxic oligomeric form of Tau (o-Tau), but in doing so they also aggravate inflammation. Attenuating mutation of the antibody Fc region can silence inflammation but also eliminates its capacity to mediate o-Tau clearance by CNS myeloid cells. Thus, there …

A Context-Forward In Vivo Functional Genomics Platform For Target Discovery And Establishing Vulnerability Context In Pancreatic Cancer, Johnathon Rose, Johnathon Lynn Rose

Dissertations and Theses (Open Access)

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a very poor patient prognosis (5-year survival of ≤ 7%). While transcriptional profiling has aided in the classification of this disease into at least two broader subtypes, this alone has so far been insufficient to inform on more nuanced patterns of oncogenic dependency. We hypothesized that a more comprehensive and granular characterization of PDAC disease diversity is required to establish relevant context for targeted therapy. To this end, we sought to establish an integrated platform to: i) more comprehensively characterize differential oncogenic signaling across our tumor models, and ii) establish …

P53 Drives A Transcriptional Program That Elicits A Non-Cell-Autonomous Response And Alters Cell State In Vivo, Sydney Moyer

Dissertations and Theses (Open Access)

Cell stress and DNA damage activate the tumor suppressor p53, triggering transcriptional activation of a myriad of target genes. The molecular, morphological, and physiological consequences of this activation remain poorly understood in vivo. We activated a p53 transcriptional program in mice by deletion of Mdm2, a gene which encodes the major p53 inhibitor. By overlaying tissue-specific RNA-sequencing data from pancreas, small intestine, ovary, kidney, and heart with existing p53 ChIP-sequencing, we identified a large repertoire of tissue-specific p53 genes and a common p53 transcriptional signature of seven genes which included Mdm2 but not p21. Global p53 activation …

Sine Oculis Homeobox Homolog 1 (Six1) Plays A Critical Role In The Progression Of Pulmonary Fibrosis., Cory Wilson

Dissertations and Theses (Open Access)

Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonia with a median survival time of 2-4 years after diagnosis. The alarming mortality rate is due to the lack of effective treatments. IPF is a chronic disease that is characterized by alveolar destruction due to increasing extracellular matrix deposition that leads to poor lung compliance, impaired gas exchange, and ultimately respiratory failure. Repetitive alveolar epithelial injury is a central process to the underlying pathology with injury to the type II alveolar epithelial cells (AT2) specifically being a key player in the pathogenesis of IPF. Recent studies have shown that …

Elucidating The Roles Of Il-15 In The Tumor Microenvironment, Rosa Maria Santana Carrero

Dissertations and Theses (Open Access)

ELUCIDATING THE ROLES OF IL-15 IN THE TUMOR MICROENVIRONMENT

Rosa M. Santana Carrero, B.S.

Advisory Professors: Shao-Cong Sun, Ph.D. & Kimberly S. Schluns, Ph.D.

Interleukin-15 (IL-15) is a factor that promotes activation, proliferation, cytotoxicity, and survival of CD8 T cells and NK cells, and has been shown to have anti-tumor effects. Moreover, loss of IL-15 expression in human colorectal tumors correlates with increased risk of relapse, diminished survival, decreased density and proliferation of T cells. All together these findings suggest that IL-15 expressed locally in the tumor microenvironment (TME) is an important mediator of anti-tumor responses by tumor infiltrating lymphocytes …

The Genome-Wide Roles Of The Lung Lineage Transcription Factor Nkx2-1 In The Regulation Of Opposing Cell Fates In Vivo, Danielle Renae Little

Dissertations and Theses (Open Access)

Lineage transcription factors mark, promote, and maintain multiple distinct cell types originating from a common progenitor. Despite their essential role, how such factors function and bind genome wide to orchestrate the epigenetic changes necessary to form and maintain these identities in vivo is unclear. One lineage transcription factor NK Homeobox 2-1 (NKX2-1) is expressed throughout the lung epithelium during development and was thought to be lost in the extraordinarily thin cell type required for gas exchange– the alveolar type 1 (AT1) cell. Complementing precise genetic knockouts with cell type-specific ChIP-seq, ATAC-seq, and scRNA-seq, our study shows that AT1 and AT2 …

The Role Of Daam1 In Kidney Development, Vanja Krneta-Stankic

Dissertations and Theses (Open Access)

Kidneys, like most organs in our bodies, consist of a network of epithelial tubules. Kidney tubules are called nephrons, and their morphology is important for kidney function. Nephrons develop from mesodermally derived aggregates of progenitor cells. The nephric progenitors organize into nephric tubules lined with hair-like sensory projections called cilia. Many diseases of the kidney are characterized by abnormal nephron morphology with current treatment aimed at symptom control. To understand the mechanisms underlying kidney diseases and achieve the development of novel therapies, a better understanding of how nephrons develop is needed. Although the actin cytoskeleton is critical for cell behaviors …

Micrornas Associated With Melanoma Inflammation And Response To Pd-1 Inhibition, Robert Szczepaniak Sloane

Dissertations and Theses (Open Access)

Melanoma is an aggressive malignancy of melanocytes with historically poor outcomes. Melanoma therapy has improved markedly over the past decade with advances in molecularly targeted agents and immunotherapies. Immune checkpoint inhibitors achieve T-cell mediated anti-tumor efficacy by blocking engagement of inhibitory checkpoints on T-cells to overcome immunosuppressive signals from tumor cells and the broader microenvironment. Despite these advances, there are a significant proportion of patients who do not benefit from existing immunotherapy strategies making it a priority to identify and target the mechanisms that confer resistance to therapy. We demonstrate that microRNAs are accurate markers of microenvironment composition with prognostic …