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2020

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Predictors Of Student Success In An Upper Division Agriculture Chemistry Class, Maddison V. May Dec 2020

Predictors Of Student Success In An Upper Division Agriculture Chemistry Class, Maddison V. May

Graduate Theses/Dissertations

To attempt to find what made students successful within a higher division class at Missouri State University’s (MSU) Darr College of Agriculture, de-identified academic records of 172 students enrolled in AGR 300 - Food and Agriculture Chemistry were studied over four semesters. Deidentified data were collected and compared to final letter grade received at the end of the class using correlation coefficients, analysis of variance, and stepwise regression. Analysis of variance was used to evaluate the influence of semester on letter grade. Correlation coefficients were used to determine and evaluate relationships between the variables and final grade. Stepwise regression was …

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Larval Fish Sampling And Scaphirhynchus Sturgeon Drift Dynamics In The Mississippi And Missouri Rivers, Hae Hyun Kim Dec 2020

Larval Fish Sampling And Scaphirhynchus Sturgeon Drift Dynamics In The Mississippi And Missouri Rivers, Hae Hyun Kim

Graduate Theses/Dissertations

Humans have been altering the natural ecosystem for centuries. These alterations provide many socioeconomic benefits (e.g., navigation and flood-control). However, these alterations can have negative ecological consequences. Large rivers across the country have been manipulated to facilitate various human activities. Rivers are dynamic systems governed by various abiotic and biotic factors. Ultimately these alterations change the natural biogeochemical cycles and reduce available habitats. These impacts likely affect riverine fishes’ ability to carry out their lifecycle. Riverine organisms, and particularly fish, have adapted to survive in free-flowing systems. Population dynamics (i.e., recruitment, growth and mortality) are the basis of fisheries management. …

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Determining A Method For Expressing And Purifying Cytochrome P450 4v2: A Protein Involved In Bietti's Crystalline Dystrophy, Cody Lane Turner Dec 2020

Determining A Method For Expressing And Purifying Cytochrome P450 4v2: A Protein Involved In Bietti's Crystalline Dystrophy, Cody Lane Turner

Graduate Theses/Dissertations

Within the Cytochrome P450 class of enzymes, there are a group known as the “orphan” cytochromes. The “orphan” classification comes from the poorly understood in vivo functionality and substrate specificity. Cytochrome P450 4V2 (CYP4V2) is one of these “orphans” and belongs to the CYP4 family. The CYP4 family is known for the omega oxidation of endogenous fatty acids. This family is most commonly found on chromosome 1 (CYP4ABXZ). CYP4V2 is unique in that its location is bound to chromosome 4 as discovered by Jiao in 2004. Mutations within the CYP4V2 gene have been associated with the …

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The Legacy Of Contamination By Lead Smelters In Missouri, Robert S. Armstrong Dec 2020

The Legacy Of Contamination By Lead Smelters In Missouri, Robert S. Armstrong

Graduate Theses/Dissertations

Missouri has a rich history of lead mining. In the smelting process lead particles are emitted, which may be toxic to plants and animals. This study focuses on two primary lead smelters, Herculaneum and Glover, in Missouri. Smelting operations have ceased at these two sites, and unlike Herculaneum, Glover has no reported lead concentrations. Findings from air and sediments of these two sites were compared to background conditions and to each other. Thirty-three samples were collected from Herculaneum and Glover (thirty samples and three replicates) and eleven samples (ten samples and one replicate) for background. For Herculaneum sediment, lead levels …

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Prospects For Enhancing The Market For Goat Meat Products: Analysis Of The 2019 Goat Meat Survey, Ashton M. Light Dec 2020

Prospects For Enhancing The Market For Goat Meat Products: Analysis Of The 2019 Goat Meat Survey, Ashton M. Light

Graduate Theses/Dissertations

The objective of this study was to identify goat meat product attributes and sociodemographic drivers of consumers’ willingness to buy to goat meat products. To do so the study used a nationwide consumer survey on goat meat preferences. A binary logit model was used to examine the factors affecting willingness to buy. Results show that gender, age, region, primary shopper, and product attribute preference for quality, price, leanness, cholesterol, and freshness significantly affect consumer willingness to buy goat sausage, jerky, burger, and patties.

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Early Pastoral Economies And Herding Transitions In Eastern Eurasia, William Timothy Treal Taylor, Julia Clark, Jamsranjav Bayarsaikhan, Tumurbaatar Tuvshinjargal, Jessica Thompson Jobe, William Fitzhugh, Richard Kortum, Robert N. Spengler, Svetlana Shnaider, Frederik Valeur Seersholm, Isaac Hart, Nicholas Case, Shevan Wilkin, Jessica Hendy, Ulrike Thuering, Bryan Miller, Alicia R.Ventresca Miller, Andrea Picin, Nils Vanwezer, Franziska Irmer, Samantha Brown, Aida Abdykanova, Daniel R. Shultz, Victoria Pham, Michael Bunce, Katerina Douka, Emily Lena Jones, Nicole Boivin Dec 2020

Early Pastoral Economies And Herding Transitions In Eastern Eurasia, William Timothy Treal Taylor, Julia Clark, Jamsranjav Bayarsaikhan, Tumurbaatar Tuvshinjargal, Jessica Thompson Jobe, William Fitzhugh, Richard Kortum, Robert N. Spengler, Svetlana Shnaider, Frederik Valeur Seersholm, Isaac Hart, Nicholas Case, Shevan Wilkin, Jessica Hendy, Ulrike Thuering, Bryan Miller, Alicia R.Ventresca Miller, Andrea Picin, Nils Vanwezer, Franziska Irmer, Samantha Brown, Aida Abdykanova, Daniel R. Shultz, Victoria Pham, Michael Bunce, Katerina Douka, Emily Lena Jones, Nicole Boivin

ETSU Faculty Works

While classic models for the emergence of pastoral groups in Inner Asia describe mounted, horse-borne herders sweeping across the Eurasian Steppes during the Early or Middle Bronze Age (ca. 3000–1500 BCE), the actual economic basis of many early pastoral societies in the region is poorly characterized. In this paper, we use collagen mass fingerprinting and ancient DNA analysis of some of the first stratified and directly dated archaeofaunal assemblages from Mongolia’s early pastoral cultures to undertake species identifications of this rare and highly fragmented material. Our results provide evidence for livestock-based, herding subsistence in Mongolia during the late 3rd and …

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Evaluation Of Wound Healing Activity Of An Ethanolic Extract Of Anacardium Occidentale Leaves In Wistar Rats, K. Meena Kumari, Amberkar Mohanbabu Vittalrao, Charitha, S. E. Praveen Kumar Dec 2020

Evaluation Of Wound Healing Activity Of An Ethanolic Extract Of Anacardium Occidentale Leaves In Wistar Rats, K. Meena Kumari, Amberkar Mohanbabu Vittalrao, Charitha, S. E. Praveen Kumar

Open Access archive

This study undertaken to screen a potential wound healing activity of an ethanolic extract of Anacardium occidentale (Ao)leaves in Wistar rats. Excision wound of 500mm2created on the back of Wistar rats. A total of thirty adult Wistar rats were prescreened and divided into five groups of six rats each. Group I and II rats were treated by normal saline (control) and povidone-iodine (standard drug), respectively. Group III and IV with 0.5% and 2% of Anacardium occidentale ointment (test drugs), respectively, and Group V rats treated with anti-wound healer drug dexamethasone, i.m. + 2% Anacardium occidentale. All drugs were applied topically …

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Awareness And Practices Of Complementary And Alternative Medicine Among Paediatric Patients Visiting Two Tertiary Care Hospitals In Mangaluru: An Interview Based Study, Meghana Tiwary, Amrita Parida, V. Manju Dec 2020

Awareness And Practices Of Complementary And Alternative Medicine Among Paediatric Patients Visiting Two Tertiary Care Hospitals In Mangaluru: An Interview Based Study, Meghana Tiwary, Amrita Parida, V. Manju

Open Access archive

This study aims to find out the details of complementary and alternative medicine (CAM) use in children, including factors favouring their use and concomitant usage of allopathic drugs along with CAM. The study also analyses the communication between allopathic practitioners and patients regarding utilization of CAM. It was an interview based study based on a semi-structured interview. The study sample included parents of children waiting in the paediatric outpatient department. A total of 200 parents were interviewed. Though most of the parents were aware about CAM, around 10% parents were ignorant. Ayurveda was the most commonly used CAM followed by …

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Metabolic Control Of Cellular Immune-Competency By Odors In Drosophila, Sukanya Madhwal, Mingyu Shin, Ankita Kapoor, Manisha Goyal Dec 2020

Metabolic Control Of Cellular Immune-Competency By Odors In Drosophila, Sukanya Madhwal, Mingyu Shin, Ankita Kapoor, Manisha Goyal

Open Access archive

No abstract provided.

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Ms-275, A Class 1 Histone Deacetylase Inhibitor Augments Glucagon-Like Peptide-1 Receptor Agonism To Improve Glycemic Control And Reduce Obesity In Diet-Induced Obese Mice, Shilpak Bele, Shravan Babu Girada, Aramita Ray, Abhishek Gupta Dec 2020

Ms-275, A Class 1 Histone Deacetylase Inhibitor Augments Glucagon-Like Peptide-1 Receptor Agonism To Improve Glycemic Control And Reduce Obesity In Diet-Induced Obese Mice, Shilpak Bele, Shravan Babu Girada, Aramita Ray, Abhishek Gupta

Open Access archive

Given its glycemic efficacy and ability to reduce the body weight, glucagon-like peptide 1 receptor (GLP-1R) agonism has emerged as a preferred treatment for diabetes associated with obesity. We here report that a small-molecule Class 1 histone deacetylase (HDAC) inhibitor Entinostat (MS-275) enhances GLP-1R agonism to potentiate glucose-stimulated insulin secretion and decrease body weight in diet-induced obese (DIO) mice. MS-275 is not an agonist or allosteric activator of GLP-1R but enhances the sustained receptor-mediated signaling through the modulation of the expression of proteins involved in the signaling pathway. MS-275 and liraglutide combined therapy improved fasting glycemia upon short-term treatment and …

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Magnetoelectric Coupling In Bismuth Ferrite—Challenges And Perspectives, N. V. Srihari, K. B. Vinayakumar, K. K. Nagaraja Dec 2020

Magnetoelectric Coupling In Bismuth Ferrite—Challenges And Perspectives, N. V. Srihari, K. B. Vinayakumar, K. K. Nagaraja

Open Access archive

Multiferroic materials belong to the sub-group of ferroics possessing two or more ferroic orders in the same phase. Aizu first coined the term multiferroics in 1969. Of late, several multiferroic materials’ unique and robust characteristics have shown great potential for various applications. Notably, the coexisting magnetic and electrical ordering results in the Magnetoelectric effect (ME), wherein the electrical polarization can be manipulated by magnetic fields and magnetization by electric fields. Currently, more significant interests lie in significantly enhancing the ME coupling facilitating the realization of Spintronic devices, which makes use of the transport phenomenon of spin-polarized electrons. On the other …

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Radiation Mitigating Activities Of Psidium Guajava L. Against Whole-Body X-Ray-Induced Damages In Albino Wistar Rat Model, Amith Kumar, Reshma Kumarchandra, Rajalakshmi Rai, Vasavi Kumblekar Dec 2020

Radiation Mitigating Activities Of Psidium Guajava L. Against Whole-Body X-Ray-Induced Damages In Albino Wistar Rat Model, Amith Kumar, Reshma Kumarchandra, Rajalakshmi Rai, Vasavi Kumblekar

Open Access archive

In the present study, we investigated radiation mitigating activities of Psidium guajava L. (P. guajava) against whole-body X- ray induced damages in albino Wistar rat model. The animals were orally administered with 200 mg/kg bodyweight of hydroalcoholic leaf extract of P. guajava for five consecutive days and on the fifth day, after the last dose of extract administration, animals were exposed to 4 Gy of X-rays. Rats were sacrificed 24 h post X–ray irradiation. The radiomitigating activity of the herb extract was assessed by micronucleus assay, histopathology of the small intestine and hematological parameters. Hepatic cyclooxygenase–2 (COX-2), interleukin–6 (IL-6) and …

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Discerning Competitive Vs. Facilitative Relationships Of Weeds On Forest Restoration Efforts At La Sal Del Rey, Tx, Mylen A. Arias Dec 2020

Discerning Competitive Vs. Facilitative Relationships Of Weeds On Forest Restoration Efforts At La Sal Del Rey, Tx, Mylen A. Arias

Theses and Dissertations

Dryland ecosystems need effective restoration strategies to address severe degradation. It is often assumed that voluntary forb weeds either compete with or have no effect on native seedlings. In contrast, theory and empirical work suggest a potential facilitative role for such forb weeds. We conducted a manipulative weed exclusion experiment at a semi-arid site in South Texas targeted for large scale forest restoration and subsequently dominated by early successional forb weeds to discern the net effect of these weeds on the growth and survival of target thornscrub tree and shrub seedlings. Overall, weed presence did not significantly affect seedling mortality …

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Genotypic Variations Of Mutans Streptococci Isolated From Dental Caries By Rep-Pcr, Hamzah Abdulrahman Salman, R. Senthilkumar Dec 2020

Genotypic Variations Of Mutans Streptococci Isolated From Dental Caries By Rep-Pcr, Hamzah Abdulrahman Salman, R. Senthilkumar

Baghdad Science Journal

Mutans streptococci (MS) are a group of oral bacteria considered as the main cariogenic organisms. MS consists of several species of genus Streptococcus which are sharing similar phenotypes and genotypes. The aim of this study is to determine the genetic diversity of the core species of clinical strains of Streptococcus mutans, Streptococcus sobrinus and Streptococcus downei by using repitative extragenic palindromic (REP) primer. The DNA of the clinical strains of S. mutans (n=10), S. sobrinus (n=05) and S. downei (n=04) have been employed in the present study, which have been previously isolated from caries active subjects. The DNA of the …

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Prevalence Of Diabetes Mellitus In Hepatitis C Patients In Wazirabad Tehsil Of Gujranwala District Of Pakistan, Shazia Shamas, Mahjabeen Zafar, Shumaila Irum, Lubna Khan, Haleema Sadia, Sadia Roshan, Tanzil Ur Rahman, Muhammad Yousaf Khan, Muhammad Ammar Dec 2020

Prevalence Of Diabetes Mellitus In Hepatitis C Patients In Wazirabad Tehsil Of Gujranwala District Of Pakistan, Shazia Shamas, Mahjabeen Zafar, Shumaila Irum, Lubna Khan, Haleema Sadia, Sadia Roshan, Tanzil Ur Rahman, Muhammad Yousaf Khan, Muhammad Ammar

Baghdad Science Journal

Hepatitis, a condition of liver’s inflammation that can be self-limiting or, in certain chances, it may lead to liver cancer, fibrosis or cirrhosis. Hepatitis viruses mainly cause hepatitis in the world. People with hepatitis C have predominant chances to develop diabetes as HCV virus participates in causing type 2 diabetes. HCV virus causes pathogenesis in two ways: it either directly destroys the β cells of pancreas or contributes to the specific autoimmunity of β cells. The present cross sectional study was done in Wazirabad Tahsil of Gujranwala District to analyze the percentage of patients suffering from hepatitis C who had …

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In Vitro Cytotoxicity Study Of Pt Nanoparticles Decorated Tio2 Nanotube Array, Shaymaa R. Baqer, Abdulkareem M. Ali Alsammarraie, Mahasin Alias, Mohammad M. F. Al-Halbosiy, Amaal S. Sadiq Dec 2020

In Vitro Cytotoxicity Study Of Pt Nanoparticles Decorated Tio2 Nanotube Array, Shaymaa R. Baqer, Abdulkareem M. Ali Alsammarraie, Mahasin Alias, Mohammad M. F. Al-Halbosiy, Amaal S. Sadiq

Baghdad Science Journal

Titanium dioxide nanotubes were synthesized by anodizing Ti sheets in the ethylene glycol solution and were covered in Pt nanoparticles onto the surface of TiO2NTs using electrodeposition method from using five derivatives of Mannich base Pt complexes which have been used as precursor of platinum. The mean size, shape, elemental composition of the titanium dioxide nanotubes and platinum deposited on the template were evaluated by different techniques such as field emission scanning electron microscope (FE-SEM), transmission electron microscopy (TEM), X-ray diffraction pattern (XRD), and energy dispersive X-ray (EDX) technique. From all these analyses, the TiO2NTs prepared and Ptnanoparticles deposited on …

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The Phonology Of Mbati, Sarah Gloria Lepage Dec 2020

The Phonology Of Mbati, Sarah Gloria Lepage

Theses and Dissertations

This description of the phonology of Mbati/Isongo (C13) (mdn) of CAR is based on a word-list recorded by native Mbati speakers. A description of nominal and verbal morphology is included as a foundation for discussing morphophonemic processes. Only open syllables and consonant-glide clusters are allowed. Alveolar and velar plosives are affricated or palatalized before the high front vowel. Prenasalized consonants act as phonological units, rather than clusters. Mid-vowels within noun roots harmonize according to the feature [ATR]. [−ATR]-dominated vowel assimilation occurs within verb stems. Vowel hiatus is resolved by glide formation, diphthong formation, elision, and epenthesis, depending on the vowels …

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A Program Evaluation Of The Effectiveness Of Fundations And Reading Strategies Professional Development, Cecile Amy Farino Dec 2020

A Program Evaluation Of The Effectiveness Of Fundations And Reading Strategies Professional Development, Cecile Amy Farino

Dissertations

This program evaluation focused on a research-based reading intervention program implemented in a public school district. It also considered the professional development provided in reading strategies and the use of the program to increase students’ reading achievement levels. A problem I identified with using a reading intervention program was it did not identify student deficiencies, and educators lacked the knowledge of basic reading foundational skills to help identify students’ deficiencies. In my research, I examined one elementary school and the administrative team members’ implementation of the reading intervention program. The literature I presented focused on two phases of reading: the …

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Dispositions Of Emotional Intelligence In School Principals, Efrain Martinez Dec 2020

Dispositions Of Emotional Intelligence In School Principals, Efrain Martinez

Dissertations

School principals address problems that extend way beyond the classroom. This qualitative study is about dispositions of emotional intelligence in school principals. The participants interviewed were novice school principals or principal coaches. The results showed that principals tend to address the needs of others more than their own. Strategies are shared on how to improve emotional intelligence. Additionally, the study provides recommendations that school districts can implement to ensure the success of school principals.

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Ensemble Of Convolutional Neural Networks To Improve Animal Audio Classification, Loris Nanni, Yandre M.G. Costa, Rafael L. Aguiar, Rafael B. Mangolin, Sheryl Brahnam, Carlos N. Silla Dec 2020

Ensemble Of Convolutional Neural Networks To Improve Animal Audio Classification, Loris Nanni, Yandre M.G. Costa, Rafael L. Aguiar, Rafael B. Mangolin, Sheryl Brahnam, Carlos N. Silla

College of Business

In this work, we present an ensemble for automated audio classification that fuses different types of features extracted from audio files. These features are evaluated, compared, and fused with the goal of producing better classification accuracy than other state-of-the-art approaches without ad hoc parameter optimization. We present an ensemble of classifiers that performs competitively on different types of animal audio datasets using the same set of classifiers and parameter settings. To produce this general-purpose ensemble, we ran a large number of experiments that fine-tuned pretrained convolutional neural networks (CNNs) for different audio classification tasks (bird, bat, and whale audio datasets). …

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Visualizing A Post-Apocalypse: Notes On New Ayoreo Cinema, Lucas Bessire, Bernard Belisário Dec 2020

Visualizing A Post-Apocalypse: Notes On New Ayoreo Cinema, Lucas Bessire, Bernard Belisário

Tipití: Journal of the Society for the Anthropology of Lowland South America

This essay describes one recent Ayoreo film and its production in order to reflect on the wider significance of lowland South American Indigenous cinema and analyses of it today. Informed by the authors’ roles in the collaborative editing of the film Ujirei, the article details how one Ayoreo filmmaker cinematically visualizes a unique aesthetic response to the aftermath of pandemic upheavals and world-ending violence – a response that pointedly exceeds any prescriptive or structuralist approach to lowland Indigenous cinema. In order to better grasp the subjective, conceptual and political implications of this project, the essay aims to craft an analytic …

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A Cathedral Not Made By Hands, Vincent Miller Dec 2020

A Cathedral Not Made By Hands, Vincent Miller

Materials from the University of Dayton Magazine Website

A theologian finds Laudato si’ — everything is connected — in an old-growth forest.

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Fundamentals Of Teaching Vocal Music Performance, Malcolm Shaquan Richardson Dec 2020

Fundamentals Of Teaching Vocal Music Performance, Malcolm Shaquan Richardson

Masters Theses

This study outlines the significance and sole purpose of developing fundamental techniques of student vocal music performances, using professional constructive evaluation that will improve their overall performance experience. One of the most practical ways to support vocalists is to provide a constructive evaluation of their performances. The implementation of constructive evaluation is to reflect upon what is being done well, discover areas of improvement or refinement, plan and facilitate important lessons, and apply the lessons to future performances. As a music teacher who is actively overseeing the development of students as performing or creating musicians, including constructive evaluation is a …

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Adventuring In The Winds: An Exploration Of Water Accessibility, Keystone Species, Environmental Justice, And Forest Fires In The Wind River Range, Rhianna Giron Dec 2020

Adventuring In The Winds: An Exploration Of Water Accessibility, Keystone Species, Environmental Justice, And Forest Fires In The Wind River Range, Rhianna Giron

Honors Program: Senior Projects (Public)

This thesis is a braided narrative that incorporates personal experience, ecological research, and poetry to explain some of the impacts of human interaction in wild spaces and of climate change. The specific areas of study in this essay are the Wind River Range, Wyoming and Nebraska. The purpose of this paper is to discuss topics related to water availability and quality, forest fires, keystone species, and social injustices related to people and environments in the Wind River Range. It is important to learn about other places than the ones we are already familiar with as it helps to instill a …

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The Role Of Liver Sinusoidal Endothelial Cells In Liver Malady Homeostasis, Fatima Cabral Dec 2020

The Role Of Liver Sinusoidal Endothelial Cells In Liver Malady Homeostasis, Fatima Cabral

Department of Biochemistry: Dissertations, Theses, and Student Research

Current literature described techniques for the purification of liver cell types through text alone. The techniques described for the isolation of liver sinusoidal endothelial cells as well as hepatocytes described here are modified from a published article in the Journal of Visualized experiments. The video protocol allows for the user to successfully isolate cells as the most difficult parts of the procedure are demonstrated visually. The detection of liver maladies such as the non-alcoholic fatty liver disease, the stage if this disease and differentiation between non-alcoholic and alcoholic fatty liver disease is demonstrated in the development of a unique panel …

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Women In Beekeeping: Impacts Of A Beekeeper Educational Program, Bridget Gross Dec 2020

Women In Beekeeping: Impacts Of A Beekeeper Educational Program, Bridget Gross

Department of Entomology: Dissertations, Theses, and Student Research

The decline in honey bee populations over the past two decades in the United States is alarming. The management provided by beekeepers to their honey bee colonies influences the survival of the colony. However, there is a lack of information on the experiences of beekeepers, specifically women beekeepers. The Center for Rural Affairs (CFRA) in Nebraska hosted the “Honey Bees on the Farm: Connecting Women Beekeepers and Women Farmers for Environmental and Economic Benefit” program that provided informal, educational events to women beekeepers and landowners. Using a convergent mixed methods design, the first research question examines the impacts of the …

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Stability Of Modified Host-Parasitoid Model With Allee Effect, Özlem A. Gümüs, A. G. Maria Selvam, R. Janagaraj Dec 2020

Stability Of Modified Host-Parasitoid Model With Allee Effect, Özlem A. Gümüs, A. G. Maria Selvam, R. Janagaraj

Applications and Applied Mathematics: An International Journal (AAM)

This paper deals with a host-parasitoid model subject to Allee effect and its dynamical behavior. Steady state points of the proposed host-parasitoid model are computed. Stability properties are analyzed with eigen values of Jacobian matrix which are determined at the steady states. Theoretical findings are supported by numerical illustrations and enhanced by pictorial representations such as bifurcation diagrams, phase portraits and local amplifications for different parameter values. Existence of chaotic behavior in the system is established via bifurcation and sensitivity analysis of the system at the initial conditions. Various phase portraits are simulated for a better understanding of the qualitative …

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Using Expanded Natural Killer Cells As Therapy For Invasive Aspergillosis, Win Mar Soe, Joan Hui Juan Lim, David L. Williams, Jessamine Geraldine Goh, Zhaohong Tan, Qi Hui Sam, Sanjay H. Chotirmall, Nur A’Tikah Binte Mohamed Ali, Soo Chin Lee, Ju Ee Seet, Sharada Ravikumar, Louis Yi Ann Chai Dec 2020

Using Expanded Natural Killer Cells As Therapy For Invasive Aspergillosis, Win Mar Soe, Joan Hui Juan Lim, David L. Williams, Jessamine Geraldine Goh, Zhaohong Tan, Qi Hui Sam, Sanjay H. Chotirmall, Nur A’Tikah Binte Mohamed Ali, Soo Chin Lee, Ju Ee Seet, Sharada Ravikumar, Louis Yi Ann Chai

ETSU Faculty Works

Invasive aspergillosis (IA) is a major opportunistic fungal infection in patients with haematological malignancies. Morbidity and mortality rates are high despite anti-fungal treatment, as the compromised status of immune system prevents the host from responding optimally to conventional therapy. This raises the consideration for immunotherapy as an adjunctive treatment. In this study, we evaluated the utility of expanded human NK cells as treatment against Aspergillus fumigatus infection in vitro and in vivo. The NK cells were expanded and activated by K562 cells genetically modified to express 4-1BB ligand and membrane-bound interleukin-15 (K562-41BBL-mbIL-15) as feeders. The efficacy of these cells was …

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Divine Command Theory And Psychopathy, Erik J. Wielenberg Dec 2020

Divine Command Theory And Psychopathy, Erik J. Wielenberg

Philosophy Faculty publications

I advance a novel challenge for Divine Command Theory based on the existence of psychopaths. The challenge, in a nutshell, is that Divine Command Theory has the implausible implication that psychopaths have no moral obligations and hence their evil acts, no matter how evil, are morally permissible. After explaining this argument, I respond to three objections to it and then critically examine the prospect that Divine Command Theorists might bite the bullet and accept that psychopaths can do no wrong. I conclude that the Psychopathy Objection constitutes a serious and novel challenge for Divine Command Theory.

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Towards Sensorimotor Coupling Of A Spiking Neural Network And Deep Reinforcement Learning For Robotics Application, Kashu Yamazaki Dec 2020

Towards Sensorimotor Coupling Of A Spiking Neural Network And Deep Reinforcement Learning For Robotics Application, Kashu Yamazaki

Mechanical Engineering Undergraduate Honors Theses

Deep reinforcement learning augments the reinforcement learning framework and utilizes the powerful representation of deep neural networks. Recent works have demonstrated the great achievements of deep reinforcement learning in various domains including finance,medicine, healthcare, video games, robotics and computer vision.Deep neural network was started with multi-layer perceptron (1stgeneration) and developed to deep neural networks (2ndgeneration)and it is moving forward to spiking neural networks which are knownas3rdgeneration of neural networks. Spiking neural networks aim to bridge the gap between neuroscience and machine learning, using biologically-realistic models of neurons to carry out computation. In this thesis, we first provide a comprehensive review …

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