Digital Commons Network^™

Characterization Of Phenolic Acids For Incorporation Into Shape Memory Polymer Foams, Jingyi Liu

Theses - ALL

Shape memory polymer (SMP) foams provide a promising new option for hemorrhage control on the battlefield; however, they lack a mechanism to control wound infections that can delay healing processes. Adding phenolic acids (PAs) into SMP foams provides a natural, non-drug option for incorporations of antioxidant and antimicrobial functionalities that may promote healing. However, PAs lack a systemic characterization of their structure/property relationships, and their chemical incorporation into SMP foams may alter their efficacy. In this work, a library of PAs was screened in terms of antioxidant and antimicrobial properties to provide a full understanding of how their structure affects …

Variation In Herbivore Effects On Grassland Primary Production: A Test Of Three Models, Jacob Penner

Theses - ALL

Grazing animals influence a wide range of plant and soil processes in the world’s grasslands. Ecologists have long understood that grazing can stimulate aboveground net primary production (ANPP), although this phenomenon has not been broadly generalizable across grasslands and grazing regimes. The mechanisms underlying grazer stimulation of ANPP are therefore of interest to a wide variety of stakeholders from ecologists to land managers. Three data-supported hypotheses offer differing explanations for the ways in which grazing interacts with resource availability to drive ANPP: the compensatory continuum hypothesis (CCH) implicates background resource availability, the limiting resource model (LRM) considers the direct effects …

Spectroscopic Analysis Of The Vanadium Oxide Catalyst During The Ketone Oxidation, Bowei Liu

Theses - ALL

Levulinic acid is a platform chemical that derived by environmental friend biomass. We have previously reported a reaction pathway to transform levulinic acid to maleic anhydride through methyl scission on supported vanadium oxide, which could achieve a 70% yield. The structure of vanadium oxide on the surface of supports can be informative for catalyst selection. We investigated the polymerization of vanadium oxide on support through diffuse reflectance UV-vis spectroscopy. Peak deconvolution of ligand to metal charge transfer region of the spectra provided knowledge of different coordinated structure. All of our catalysts have bulk V2O5 that exists on the surface of …

Court Review: The Journal Of The American Judges Association Vol. 55, No. 4

Court Review: Journal of the American Judges Association

Court Review, the quarterly journal of the American Judges Association, invites the submission of unsolicited, original articles, essays, and book reviews. Court Review seeks to provide practical, useful information to the working judges of the United States and Canada. In each issue, we hope to provide information that will be of use to judges in their everyday work, whether in highlighting new procedures or methods of trial, court, or case management, providing substantive information regarding an area of law likely to be encountered by many judges, or by providing background information (such as psychology or other social science research) …

Exploring The Spirit In U.S. Audiences: The Role Of The Virtue Of Transcendence In Inspiring Media Consumption, Sophie Janicke-Bowles, Arthur A. Raney, Mary Beth Oliver, Katherine R. Dale, Robert P. Jones, Daniel Cox

Communication Faculty Articles and Research

Little is yet known about audiences who routinely seek out media content that is inspirational in nature. The current study expands the research on inspirational media by utilizing a nationally representative sample of U.S. audiences (n = 2,016) to explore relationships between inspiring media exposure, trait transcendence, and self-transcendent emotions. Results show that media content is a reliable source for everyday self-transcendent emotional experiences in U.S. audiences. These experiences are most frequently encountered by persons with high levels of trait spirituality and gratitude. The profile of U.S. audiences that seek out inspiring media is discussed.

Fighting Food Insecurity For Nyc Children And Youth: Urban Agriculture And Food Justice, Devin C. O'Mara

Student Theses 2015-Present

The positive benefits of urban agriculture go beyond just providing fresh and healthy food to metropolitan areas. As the practice of urban farming has become increasingly more popular over the last decade or so, it has proven to develop community relations and aide with metropolitan and global issues such as poverty. Children and teens especially benefit from urban agriculture, specifically those that comes from underprivileged homes that may not have the resources to obtain fresh food every day. A shocking number of kids can go hungry every day due to lack of available food. Many children that live in metropolitan …

Broadening Footpaths: Trail Ecology And Ethic, Miles H. Frank

Student Theses 2015-Present

There is not always a clear distinction between what constitutes responsible use and what constitutes overuse with regard to recreation and the environment. Even on a small scale, outdoor recreation will always leave a footprint. This paper addresses the ecological impact that the growth of outdoor recreation has had on the environment. Using a multi-disciplinary approach, it provides a holistic analysis of the issue from the scale of local vegetation to that of national policy and wilderness philosophy. Chapter one focuses on the immediate impacts of the overuse of hiking trails and the subsequent environmental degradation of at-risk areas. It …

Breaking Ground On New Agricultural Models: Industrial Agriculture And The Local Food Movement, Elizabeth Nealon

Student Theses 2015-Present

This paper discusses and examines the longstanding issues surrounding industrial food production as it currently exists and the various ways that purpose-driven enterprises and environmentally-conscious consumers in the United States have been able to steer food production in a more sustainable direction. Over the course of the technological revolution, people living in metropolitan areas have become so distanced from farms and the processes of food production that many are ignorant of the realities of the food industry. Chapter 1 addresses these issues by presenting quantitative data that lays out a timeline of the evolution of the food and agriculture industry …

Functional Implications Of Nlrp1 Variants For Autoimmune Disease, Laura J. Westhoff

Undergraduate Honors Theses

NLRP1 is a protein-coding human gene that plays a crucial role in the NLRP1 inflammasome. Variants to the NLRP1 gene have been associated with autoimmune and autoinflammatory diseases. We examined the effects of polymorphisms at two SNPs on cytokine levels and NLRP1 gene expression in 50 human volunteers without diagnosed autoimmune disease. NLRP1 was genotyped at SNPs rs2670660 and rs12150220 and individuals who were homozygous at one or more SNP were selected for further analysis. Serum IL-18 and IL-1β levels were quantified using ELISA. NLRP1 gene expression was measured using real-time PCR. A strong linkage was found between genotypes of …

The Effects Of Replacement Of Fish Meal Protein With A Mixture Of Poultry By-Product Meal, Fish Silage And Fish Protein Hydrolysate On The Growth Performances Of Asian Sea Bass (Lates Calcarifer), Yu-Cong Hong, Angela Chien, Shyn-Shin Sheen

Journal of Marine Science and Technology–Taiwan

This feeding trial was conducted to investigate the effects of replacement of dietary fishmeal (FM) with a mixture of poultry by-product meal (PBM), fish silage (FS) and fish protein hydrolysate (FPH) on the growth performances of the Asian sea bass Lates calcarifer. Five isonitrogenous (46% crude protein) and isolipidic (12% crude lipid) diets were formulated to replace 0 (CON), 25 (FM 25), 50 (FM 50), 75 (FM 75) and 100% (FM 100) of fishmeal protein with the protein mixture (78% PBM, 11% FS, and 11% FPH). One additional diet, namely POM was designed to completely replace FM protein with PBM. …

Why Do Some Individuals Abstain From Voting? The Impact Of Age, Education, And Confidence In The Court System On Voter Participation, Kristina Taylor

XULAneXUS

The purpose of this research is to discover why some individuals abstain from voting in America. Using this information, countries may be able to increase voter turnout amongst their population. Literature provided several theories as to why individuals abstain from voting. This research focused on the impact of: age, education, and confidence in the courts system. A regression was conducted using GSS 1998 survey data to observe the impact of these three variables on voter turnout. It was found in this model that age and education have a statistically significant impact on voter turnout, but confidence in the court system …

Reconstruction Of Propeller And Complex Ship Hull Surface Based On Reverse Engineering, Guan Guan, Wen-Wen Gu1

Journal of Marine Science and Technology–Taiwan

To quickly obtain the digital model of ship surface for detection and redesign, a reconstruction method for propeller and ship surface is proposed. Three-dimensional point cloud data of ship hull was obtained by laser scanning technology and the cloud data was preprocessed by iterative closest point (ICP) algorithm and chord deviation method. Then the surface was reconstructed with traditional surface modeling method and fast surface modeling method. By comparing the reconstructed surface with the initial point cloud data, the error of the reconstructed model was obtained. The result shows that the reconstructed surface gains good smoothness and small error. With …

Senior Day December 2019, University Of Michigan Law School

Commencement and Honors Materials

Program for the December 20, 2019 Senior Day ceremonies.

Design And Development Of A Perfusion Bioreactor With Internal Volume Expansion And Cell Retention For Cell And Gene Therapy Manufacturing, Corinna Doris

KGI Theses and Dissertations

Economically producing patient-specific cell therapies at commercial levels remains a challenge as it requires manufacturing separate batches per patient where the production system must be scaled-out rather than scaled-up to supply more patient doses. The resulting high production cost and consequent price-point can limit patient access. Specifically, the current cell expansion processes are highly manual and laborious, with the number and complexity of operations and components increasing the opportunities for failure and contamination. This work therefore aims to design a mechanically simple bioreactor that is better suited for scale-out by consolidating the cell expansion process to fewer components, vessels, and …

Big Ink V. Bigger Tech, Ramsi Woodcock

Law Faculty Popular Media

When in 2011 Paul Krugman attacked the press for bending over backwards to give equal billing to conservative experts on social security, even though the conservatives were plainly wrong, I celebrated. Social security isn’t the biggest part of the government’s budget, and calls to privatize it in order to save the country from bankruptcy were blatant fear mongering. Why should the press report those calls with a neutrality that could mislead readers into thinking the position reasonable?

Journalists’ ethic of balanced reporting looked, at the time, like gross negligence at best, and deceit at worst. But lost in the pathos …

Mission As Virtuous Practice: A Theology Of Mission Through The Lens Of Virtue Ethics, Michael Niebauer

Electronic Theses and Dissertations

This work uses theological virtue ethics as a guide both for critiquing various models of Christian mission and for constructing a model of mission that adequately addresses these criticisms. The first section of the dissertation (chapters one, two, and three) is devoted to an assessment of three major models of mission, which I have labeled mission as the missio Dei, mission as growth, and mission as dialogue. This assessment generates three recurring issues within the field of missiology that have remained largely unresolved: the problems of distinction, agency, and persuasion. The second half of the dissertation (chapters four, five, …

Neutronic Investigation Of Alternative & Composite Burnable Poisons For The Soluble-Boron-Free And Long Life Civil Marine Small Modular Reactor Cores, Syed B. Alam, Bader Almutairi, Tuhfatur Ridwan, Dinesh Kumar, Cameron S. Goodwin, For Full List Of Authors, See Publisher's Website.

Nuclear Engineering and Radiation Science Faculty Research & Creative Works

Concerns about the effects of global warming provide a strong case to consider how best nuclear power could be applied to marine propulsion. Currently, there are persistent efforts worldwide to combat global warming, and that also includes the commercial freight shipping sector. In an effort to decarbonize the marine sector, there are growing interests in replacing the contemporary, traditional propulsion systems with nuclear propulsion systems. The latter system allows freight ships to have longer intervals before refueling; subsequently, lower fuel costs, and minimal carbon emissions. Nonetheless, nuclear propulsion systems have remained largely confined to military vessels. It is highly desirable …

Evidence For Late-Stage Eruptive Mass Loss In The Progenitor To Sn2018gep, A Broad-Lined Ic Supernova: Pre-Explosion Emission And A Rapidly Rising Luminous Transient, Anna Y.Q. Ho, Daniel A. Goldstein, Steve Schulze, David K. Khatami, Daniel A. Perley, Mattias Ergon, Avishay Gal-Yam, Alessandra Corsi, Igor Andreoni, Cristina Barbarino, Eric C. Bellm, Nadia Blagorodnova, Joe S. Bright, E. Burns, S. Bradley Cenko, Virginia Cunningham, Kishalay De, Richard Dekany, Alison Dugas, Rob P. Fender, Claes Fransson, Christoffer Fremling, Adam Goldstein, Matthew J. Graham, David Hale, Assaf Horesh, Tiara Hung, Mansi M. Kasliwal, N. Paul M. Kuin, S. R. Kulkarni, Thomas Kupfer, Ragnhild Lunnan, Frank J. Masci

Faculty Publications

We present detailed observations of ZTF18abukavn (SN2018gep), discovered in high-cadence data from the Zwicky Transient Facility as a rapidly rising (1.4 ± 0.1 mag hr-1) and luminous (Mg,peak = -20 mag) transient. It is spectroscopically classified as a broad-lined stripped-envelope supernova (Ic-BL SN). The high peak luminosity (Lbol ≳ 3 × 1044 erg s-1), the short rise time (trise = 3 days in g band), and the blue colors at peak (g-r ∼ -0.4) all resemble the high-redshift Ic-BL iPTF16asu, as well as several other unclassified fast transients. The early discovery of SN2018gep (within an hour of shock breakout) enabled …

Troubling “Technologies”: Exploring The Global Learning Xprize Using The Frameworks Of Skinner And Foucault, Tanya Elias

Current Issues in Emerging eLearning

This work focuses on the question: What might be wrong with large-scale approaches to learning? In posing this question, my purpose is not to suggest that large-scale approaches have no role to play within a complex educational landscape. Rather, I seek to introduce a starting point for more critical and nuanced approaches to achieving proper scale within digital learning, whether big and small. Organized around a series of stories from a train-ride home, I introduce a series of process-based “technologies” as defined by Skinner (1971) and Foucault (1988). After contrasting key concepts of Skinner and Foucault, I apply Foucault’s framework …

Educator Professional Conversations Via Twitter Chat: Speech Acts And Intentions In #Pdbookclub, Suzanne L. Porath

Current Issues in Emerging eLearning

#PDBookChat was an affinity space of educators who read a professional book together and reflected on their learning through blogs, Twitter, and Google+. The book study culminated with an hour-long synchronous Twitter chat. Using Computer-Mediated Discourse Analysis (Herring, 2001) and speech act theory (Searle, 1976) this paper focused on the Twitter chat to examine the discussion among the participants, the specific ways in which they connected their responses to each other and the content of the professional book they read, and provided an analysis of the key themes of the chat. This research provides evidence of how educators use Twitter …

Book Review: Hitler’S Atrocities Against Allied Pows: War Crimes Of The Third Reich, Timothy Heck

Genocide Studies and Prevention: An International Journal

Hitler’s Atrocities Against Allied PoWs cannot be regarded as an academic study of the fate awaiting captured Allied servicemen and women. Its narrow focus, socio-political goal, and limited engagement with the historiography prevent it from serving as more than a survey text or springboard. Chinnery attempts to tie the individual fates to a larger argument that the German armed forces and their security force compatriots were systematically responsible for the abuses described in the book. While the individual cases are compelling and some have a clear connection to explicit policies, the book does not succeed in linking its other examples …

Exploring Appreciative Advising As An Equity Approach For African American Students: A Grounded Theory Study Of Academic Advisors At Predominantly White Institutions (Pwis), Valerie Harper

Electronic Theses and Dissertations

ABSTRACT

EXPLORING APPRECIATIVE ADVISING AS AN EQUITY APPROACH FOR AFRICAN AMERICAN STUDENTS: A GROUNDED THEORY STUDY OF ACADEMIC ADVISORS AT PREDOMINANTLY WHITE INSTITUTIONS (PWIs)

By

Valerie J. Harper

October 28, 2019

Dissertation supervised by Professor Gretchen Givens Generett

African American matriculation into postsecondary education continues to rise, but degree conferral remains low (Hoston, Graves, & Fleming-Randle, 2010). Arguably, Harper and Hurtado’s (2007) research, as far back as 1992, stated black students and other students of color have dealt with alienation, isolation, and stereotyping at PWIs; this continues to persist today (Lee, 2018), which may interrupt the academic success of African …

An Exploration Of Communication Ethics Scholarship And Economic Spheres, Andrew Tinker

Electronic Theses and Dissertations

This project examines communication ethics scholarship to understand how economics is understood within the field and to establish coordinates for scholars to discuss economic spheres as phenomena that affect communication ethics. Scholars draw from the tradition of virtue ethics to mark communication ethics inquiry as that which explores the practices that protect and promote the “good.” Philosophers of communication and communication ethicists have developed paradigmatic metaphors for the field that allow us to understand the formation of ethical guidelines within communities both familial, corporate, and national, that promote and protect various goods. These metaphors include “hierarchy” and “sameness” from Charles …

Exploratory Study On Trust, Distrust, And Credibility In Machine Journalism, Stephen Wonchul Song

Dissertations - ALL

The current study investigated the effect of machine-generated journalism. Specifically, the effect of machine journalism compared to human journalist on the perceptions of credibility and distrust for news articles on controversial topics was explored. To further extend the well- established theories of credibility in journalism, this study introduced the concept of distrust as a construct that is distinct from credibility or trust. The relationship between trust and hostile media effect was explored. Finally, this study investigated if trust and hostile media effect are related to the perception of fake news. The results show that distrust was indeed distinct from credibility …

Charge-Based Optimization Of Neurotensin For Neurotensin-Receptor-1 Targeting Utilizing A One-Bead One-Compound Peptide Library Approach, Trey Neeley

Theses & Dissertations

Neurotensin-receptor-1 (NTSR1) is regularly overexpressed in various cancers and contributes to the proliferation, survival, migration, invasion, and angiogenesis of tumors. NTSR1-targeting vectors have demonstrated promise in both diagnostic and therapeutic aspects. Unfortunately, the relatively poor in vivo metabolic stability and high renal uptake and retention of NTSR1-targeted compounds have hampered the translation to the clinic. In this research, we utilized a one-bead one-compound (OBOC) peptide library approach to make targeted modifications at the naturally charged residues of an NTS (4-13) sequence to discover an NTS derivative with comparable affinity to NTSR1, acceptable in vivo stability, and tolerable renal retention. Subsequent …

Delivery Of Small Molecule And Rna Using Synthetic Polymeric Micelles And Multifunctional Exosomes For The Treatment Of Type 1 Diabetes, Yang Peng

Theses & Dissertations

Type 1 diabetes is one of the most challenging chronic autoimmune diseases. The destruction and dysfunction of insulin-secreting β cells are the results of inflammatory infiltration and the synergistic effect of multiple immune cells. The aim of this dissertation is to develop novel and reliable therapeutic approaches to advance the treatment of T1D: including chemical modification of a broad-spectrum immunosuppressant, co-application of small molecule based immune intervention and siRNA based β cell preservative therapy, and administration of a PI3K-δ/γ dual inhibitor to specifically target immune cells, utilizing synthetic polymeric micelles or natural produced multi-functional exosomes derived from human bone marrow …

Molecular Insights Into Major Peripheral T-Cell Lymphoma Entities With Advances In A Representative Model System, Tayla B. Heavican

Theses & Dissertations

Peripheral T-cell lymphoma (PTCL) is a group of complex clinicopathological entities associated with an aggressive clinical course. Angioimmunoblastic T-cell lymphoma (AITL) and PTCL-not otherwise specified (PTCL-NOS) are the two most frequent categories accounting for more than 50% of PTCLs. Gene expression profiling (GEP) defined molecular signatures for AITL and delineated biological and prognostic subgroups within PTCL-NOS (PTCL-GATA3 and PTCL-TBX21). Genomic copy number analysis and targeted sequencing revealed unique genomic abnormalities and oncogenic pathways, indicating distinct oncogenic evolution. PTCL-GATA3 exhibited higher genomic complexity characterized by frequent loss or mutation of tumor suppressor genes targeting the CDKN2A/B-TP53 axis and PTEN-PI3K pathways. …

Computational Studies And Design Of Pparγ And Glut1 Inhibitors, Suliman Almahmoud

Theses & Dissertations

The peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-dependent transcription factor of the nuclear receptor superfamily that controls the expression of a variety of genes involved in fatty acid metabolism, adipogenesis, and insulin sensitivity. PPARγ is a target for insulin-sensitizing drugs, and it plays a significant function in prostate cancer. PPARγ antagonists have anti-proliferative effects in a broad range of hematopoietic and epithelial cell lines. The ligand binding domain (LBD) of PPARγ is large and has orthosteric and allosteric binding sites. Several PPARγ-ligand co-crystal structures show two bound molecules, one to the orthosteric pocket and a second to the allosteric …

Enhancing The Identification Of Rheumatoid Arthritis-Associated Lung Disease, Bryant England

Theses & Dissertations

Rheumatoid arthritis (RA) is a systemic autoimmune disease that predisposes afflicted individuals to reduced quality of life, physical disability, and premature mortality. While joint involvement is the primary manifestation of RA, extra-articular features including lung disease are responsible for a significant portion of the excess mortality. In this dissertation I demonstrate the contribution of chronic lung diseases to premature mortality in RA, contrasting with the more widely recognized comorbidity in RA of cardiovascular disease. Then, I establish that a novel serum biomarker, anti-malondialdehyde-acetaldehyde adduct (MAA) antibody, is associated with the presence of interstitial lung disease (ILD) in RA subjects. Further …

Mechanism Of Bax/Bak Activation In Apoptotic Signaling, Kai Huang

Theses & Dissertations

The Bcl-2 family proteins, including the anti-apoptotic members, pro-apoptotic effectors Bax/Bak, and the BH3-only proteins, are key components of the mitochondrial apoptotic pathway. The BH3-only protein Bid is critical for the mitochondrial pathway of apoptosis after TRAIL-induced death receptor activation. However, the mechanism of Bid activation during TRAIL-induced apoptosis is unclear. By putting back wild-type and mutants of Bid in Bid deficient (Bid KO) and Bid/Bax/Bak TKO colon cancer cells, we demonstrated that cleavage by caspase 8 and mitochondrial targeting are critical events for Bid activation. One of the biggest mysteries in apoptosis is how Bax/Bak was activated by BH3-only …