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Brca1 & Ctdp1 Brct Domainomics In The Dna Damage Response, Kimiko L. Krieger

Theses & Dissertations

Genomic instability is one of the enabling characteristics of cancer. DNA damage response pathways are important for genomic integrity and cell cycle progression. Defects in DNA damage repair can often lead to cell cycle arrest, cell death, or tumorigenesis. The activation of the DNA damage response includes tightly regulated signaling cascades that involve kinase phosphorylation and modular domains that scaffold phosphorylated motifs to coordinate recruitment of DNA repair proteins. Modular domains are conserved tertiary structures of a protein that can fold, function, and evolve independently from an intact protein. One of the most common modular domains involved in DNA damage …

Role Of Astrocyte-Derived Extracellular Vesicles In Neuroinflammation Mediated By Drug Abuse, Ke Liao

Theses & Dissertations

Neuronal damage and neuroinflammation is a hallmark feature of HIV-associated neurological disorders (HANDs). Opioids abuse accelerates the incidence and progression of HAND; however, the mechanisms underlying the potentiation of neuropathogenesis by these drugs remain elusive. Extracellular vesicles (EVs) are essential conduits in HIV and drug abuse-mediated synaptodendritic injury and neuroinflammation. Findings from our group have demonstrated that astrocyte-derived EV (ADEV)-miRNA-29b mediates HIV Tat and morphine-induced neuronal injury, thus underscoring the importance of such interactions in NeuroHIV.

Besides, HIV Tat and morphine-mediated synaptodendritic injury via ADEVs, we are also interested in whether ADEVs contributes to neuroinflammation. Microglia are critical players in …

The Role Of Reactive Oxygen Species In Regulating Macrophage And Fibroblast Activation Within The Breast Cancer Tumor Microenvironment, Brandon J. Griess

Theses & Dissertations

The tumor microenvironment (TME) is a key determining factor in breast cancer, especially the more aggressive subtype triple negative breast cancer (TNBC). The activated fibroblasts and macrophages within the TME have many tumor promoting functions. Therefore, targeting their activation presents a novel therapeutic approach in TNBC. My work studied the role of reactive oxygen species (ROS) during fibroblast and macrophage activation in breast cancer.

My studies showed that expression of the secreted antioxidant enzyme, EcSOD, is silenced in breast cancer samples, in part, via increased promoter methylation. The re-expression of EcSOD inhibited c-Met activation in the TNBC cell line, MDA-MB231. …

Defining The Role Of Tyrosine Phosphorylation In The Regulation Of Connexin43 In Cardiac Diseases, Li Zheng

Theses & Dissertations

Connexins are integral membrane proteins that oligomerize to form gap junction channels. Ions and small molecules diffuse intercellularly through these channels, allowing individual cellular events to synchronize into the functional response of an entire organ. Gap junction channels composed of Connexin43 (Cx43) mediate electrical coupling and impulse propagation in the normal working myocardium. In the failing heart, Cx43 remodeling (decreased expression, altered phosphorylation state, loss at intercalated discs, and increased presence at lateral membranes) contributes to rhythm disturbances and contractile dysfunction. While there is considerable information regarding key interactions of Cx43 in the regulation of gap junction channels, unfortunately, the …

Troubling The Water: Dismantling The Ideology Of Separate Spheres, Lisa Weddell

Electronic Theses and Dissertations

This dissertation examines nineteenth century U.S. women’s maritime writings to re-evaluate and more accurately represent the roles women played in society. I contend that the nineteenth century ship is a microcosm of the United States and women’s sea experiences and maritime writings reveal their lived experiences and the visible roles they played in their relationships and in public politics. Women’s maritime writings, I argue, challenge ideologies of “True Womanhood” that define women as submissive and passive. Instead, these texts demonstrate how women equally contributed to establishing national identity in the United States by defining appropriate gender performance for men and …

A Case Study Of An Online Teacher Study Group As A Digital Professional Development Tool, Jessica Martin

Electronic Theses and Dissertations

In recent years, there appears to have been a shift in professional development approaches for teachers from short-term workshops to teacher communities of professional practice, which extend over a while and focus on the expert knowledge teachers need to use in their setting (Goya, 2014). A supportive approach to teacher learning communities is a teacher study group. An even more promising and flexible approach to teacher learning communities in a global aspect is an online teacher study group. An online teacher study group provided a universal and flexible venue to engage in collaborative discussion between general education and special education …

Determining Nurse Practitioner Core Competencies Utilizing A Delphi Approach, Tracey Chan

Electronic Theses and Dissertations

Background: Competency-based education (CBE) has been recommended for nurse practitioner (NP) education. To implement CBE, existing NP core competencies need to be reduced in number and refined.

Purpose: This study refined and reduced redundancy in the National Organization of Nurse Practitioner Faculties (NONPF) and American Association of Colleges of Nursing (AACN) NP core competencies through the consensus of experts in NP practice. This study used the current NP Core Competencies (NONPF, 2017), the Essentials of Doctoral Education for Advanced Nursing Practice (AACN, 2006), and the Common Advanced Practice Registered Nurse Doctoral-Level Competencies,(AACN, 2017a) …

A Darker Side Of Venus: An Empirical-Phenomenological Study Of Women's Negative Experiences Encountering Pornographic Imagery, Rebecca Gimeno

Electronic Theses and Dissertations

This empirical-phenomenological study explores the psychological dimensions of negatively encountering a pornographic image. The study includes four participants, all adult women who have had an adverse encounter with a pornographic image within the past five years at the time of the data collection. The recollected experiences of the participants were collected through written narratives as well as semi-structured interviews.

The written narratives and recorded audio interviews were transcribed and subsequently analyzed using an empirical-phenomenological analysis, a process that yielded situated structures. From this analysis, thematic elements of each structure were brought to light. Some of the thematic elements that were …

The Mediating Role Of Differentiation In The Relationship Between Mindfulness And Working Alliance, Caleb P. Thompson

Electronic Theses and Dissertations

This study involved a mediation analysis exploring the relationship of counselor’s perceptions of mindfulness and working alliance through differentiation of self. Sample data (N=80) was collected and analyzed using the PROCESS mediation model to quantitatively determine the indirect effect of counselor’s perceptions of mindfulness and their perceptions of working alliance through the variable of differentiation of self. This indirect effect was not statistically significant, b = .08, 95% CI [-.11, .25], therefore no mediating effect was demonstrated for differentiation. A follow-up moderation analysis was also conducted on these same three variables. Results revealed that at low levels of …

The Role Of Individual Difference In Predicting Psychopathology Following Peer Victimization, Miranda Evans

LSU New Orleans Theses and Dissertations

eer victimization is a common experience that is associated with later psychopathology. However, there is inconsistency in the strength and statistical significance of this effect. The current study used two methods to try to understand this inconsistency. First, co-occurring internalizing and externalizing symptoms were considered dimensionally. Second, the present study considered temperament as a potential moderator to explain the multifinality of outcomes that occur following peer victimization. A community sample (N = 387; 52% female) of early adolescents (11-15) from a longitudinal study of risk and resilience factors for psychopathology was utilized to test hypotheses. Cross-lagged examinations between victimization and …

Multi-Agent Narrative Experience Management As Story Graph Pruning, Edward T. Garcia

LSU New Orleans Theses and Dissertations

In this thesis I describe a method where an experience manager chooses actions for non-player characters (NPCs) in intelligent interactive narratives through story graph representation and pruning. The space of all stories can be represented as a story graph where nodes are states and edges are actions. By shaping the domain as a story graph, experience manager decisions can be made by pruning edges. Starting with a full graph, I apply a set of pruning strategies that will allow the narrative to be finishable, NPCs to act believably, and the player to be responsible for how the story unfolds. By …

Expanding The Definition Of Liminality: Speculative Fiction As An Exploration Of New Boundaries, Dianna C. Lacy

LSU New Orleans Theses and Dissertations

Speculative fiction allows an expanded view of literature and so allows scholars to explore new boundaries in the way words and ideas work. In the titular character of The Last Unicorn by Peter S. Beagle, the reader sees an expansion of self through liminality while A Scanner Darkly by Philip K. Dick explores its collapse. In order to portray each of these the character examined must move though one seems to move upward and the other downward. This idea of movement is only part of what expands the idea of liminality past the traditional idea of a doorway to create …

How To Get A Job In Book Publishing, Grecia Medina

LSU New Orleans Theses and Dissertations

There are many different doorways into the world of book publishing and it can be challenging, but there are choices that can make it easier. Aspiring publishers often have a hard time breaking into this world because they have no guide. This thesis will be a guide to traversing the different avenues into the world of publishing. Prospective publishers, editors, and writers will be provided with a landscape of what it’s like to work in book publishing. It will also cover the two different ways that people become publishers, an overview of the basic requirements that publishing houses look for …

An Experimental And Numerical Study Of High Temperature Gaseous Flow Through An Open Cell Silicon Carbide Foam Heater, Denis Pansolin

LSU New Orleans Theses and Dissertations

No abstract provided.

Vertical Acoustic Propagation In The Non-Homogeneous Layered Atmosphere For A Time-Harmonic, Compact Source, Edward J. Yoerger Jr

LSU New Orleans Theses and Dissertations

In this work we study vertical, acoustic propagation in a non-homogeneous media for a spatially-compact, time-harmonic source. An analytical, 2-layer model is developed representing the acoustic pressure disturbance propagating in the atmosphere. The validity of the model spans the distance from the Earth's surface to 30,000 meters. This includes the troposphere (adiabatic), ozone layer (isothermal), and part of the stratosphere (isothermal). The results of the model derivation in the adiabatic region yield pressure solutions as Bessel functions of the First (J) and Second (Y) Kind of order $-\frac{7}{2}$ with an argument of $2 \Omega \tau$ (where $\Omega$ represents a dimensionless …

All Trails Lead To Sterling: How Sterling Brown Fathered The Field Of Black Literary And Cultural Studies, 1936-1969, Amber E. Zu-Bolton

LSU New Orleans Theses and Dissertations

Poet and professor Sterling A. Brown (1901-1989) played a significant role in the birth of black literary and cultural studies through his literary and academic careers. Brown helped to establish a new wave of black cultural and folklore studies during his time as the “Director of Negro Affairs” for the Federal Writers’ Project. As a professor at Howard University, Brown influenced black literary studies through his literary criticisms and seminars and his role as a mentor to literary figures of the next generations. Through letters to and from Sterling Brown and manuscripts, this thesis argues that Brown’s poetry, publications and …

In Search Of Meaning, Fabiano Sarra

Theses

When I came across the book Baskets and Basket Makers in Southern Appalachia, I felt a deep reverence for the craft of basketry that marked the beginning of my thesis research. What started as a new discovery for generating volume led to a search for an intangible essence that emanated from these objects. The baskets in that book had a certain feel to them, they had a soul, a proof of existence and a life of utility. Their honest radiance transports the viewer to a different time and place, drawing visual connections with the maker who crafted the object with …

Anticipation, Accompaniment, And A Good Death In Perinatal Care., Bryanna S. Moore, Brian S. Carter, Bryan Beaven, Katie House, Joel House

Manuscripts, Articles, Book Chapters and Other Papers

The ethics of perinatal care, and the experiences of families who receive such care, remains a nascent area of inquiry. It can be hard to see how existing "good death" constructs apply to the experiences of fetal patients and their families. In this paper, we explore two themes raised by a case at our fetal health center: anticipation and accompaniment. In this case, a mother presented to our fetal health center; her unborn son, our fetal patient, was diagnosed with life-threatening hypoplastic left heart syndrome and endocardial fibroelastosis. The parents were told that their son's life expectancy, upon birth, was …

Learning Together In Public And In Private: Exploring Learner Interactions And Engagement In A Blended-Platform Mooc Environment, Arianna Montero-Colbert, Natalie Delia Deckard, Bonnie Stewart, Sundi Richard, Alexa Nanan

Current Issues in Emerging eLearning

With the growing popularity of connectivist MOOCs, the aim of facilitators has increasingly shifted from helping students meet completion-oriented goals to encouraging meaningful engagement among participants. In this paper, we study the relationship between platform of engagement and learner participation, controlling for relevant demographic factors of participants including gender, age, and level of education attained. Our study employs four distinct measures of participatory engagement: autonomous learning, knowledge reproduction, information networking, and scholarly engagement. We find that on the public platform of Twitter, participants were more likely to exhibit meaningful engagement patterns across all measures studied than they were on the …

Comparative Reflection On Best Known Instructional Design Models: Notes From The Field, Bengi Birgili

Current Issues in Emerging eLearning

This paper is intended to stimulate discussion on historical and evolving instructional design models in an educational era. After enriching the vision of what constitutes an instructional design, the paper explores the historical development and improvement of instructional design processes and models. The instructional design models of Dick and Carey, Morrison, Ross and Kemp, Posner and Rudnitsky, and Smith and Ragan are identified herein as being among the best known, most popular, and most widely applied instructional design models in the field of educational sciences. The philosophical underpinnings and the rationales for the arrangement of components in each instructional design …

Caregiver Perspectives On Telehealth: A Service Delivery For Occupational Therapy, Rebecca Johnston

Student Capstone Papers

Telehealth; also known as telerehabilitation, telecare, telemedicine, teletherapy, and telepractice; is an emerging healthcare service that is utilized in various healthcare facilities with a span of ages, conditions, and locations (World Federation of Occupational Therapy [WFOT], 2014). Telehealth utilizes information and communication technologies to deliver services to a patient when the healthcare provider is not in the same location (WFOT, 2014). Telehealth can provide an online platform for evaluations, consultations, monitoring, supervision, and intervention with patients and other professionals (WFOT, 2014).

Telehealth is an emerging method of delivering occupational therapy (OT) services to various populations, including: children and youth; productive …

Sequential Methods For Non-Parametric Hypothesis Testing, Prashant Khanduri

Dissertations - ALL

In today’s world, many applications are characterized by the availability of large amounts of complex-structured data. It is not always possible to fit the data to predefined models or distributions. Model dependent signal processing approaches are often susceptible to mismatches between the data and the assumed model. In cases where the data does not conform to the assumed model, providing sufficient performance guarantees becomes a challenging task. Therefore, it is important to devise methods that are model-independent, robust, provide sufficient performance guarantees for the task at hand and, at the same time, are simple to implement. The goal of this …

Snowstorms In Upstate New York: Synoptics, Spatial Modeling And Temporal Variability, Justin Joseph Hartnett

Dissertations - ALL

This dissertation examines the characteristics of snowstorms that affect Central New York, a subsection of the eastern Great Lakes region, in a series of chapters organized as journal articles. The first article develops a classification scheme to categorize snowstorms in Central New York from the 1985/86 season to the 2014/15 season. Twelve different snowstorm types were classified by their connection to the Great Lakes, the presence or absence of a synoptic low, or their area of cyclogenesis.

The second article uses the 2055 classified snowstorms to examine their relative contribution to seasonal snowfall totals. Although lake-effect snowstorms are the dominant …

Raising An Indoor Generation: Outdoor Environmental Education Impact On Adolescent Development, Daisy Elizabeth Bewley

Student Theses 2015-Present

In an increasingly digital world, children are growing up with less involvement and interaction with the environment. Hands-on and experiential learning is less popular in schools and a more test-oriented and numerical evaluation is increasingly popular. This thesis explores the decrease in outdoor environmental education and the impact that has on adolescent development and developmental milestones in children. This impact extends past just mental development and impacts the physical health development of children. Obesity, attention deficit disorders, and other behavioral issues are just a few of the signs of the problems that have arisen due to a decrease in environmental …

Designing The City, Sustainably: Sustainability And Climate Change Resiliency In New York City, Cosima Balletti-Thomas

Student Theses 2015-Present

Abstract

This paper explores how New York City and especially Manhattan has integrated sustainability into its agenda as a coastal metropolitan nucleus. Secondly, it assesses the New York City’s resiliency strategies that utilize environmental policy and design to confront its vulnerability to changes in the environment on account of global climate change, which has primarily manifested in the Northeastern region in the form of sea level rise, storm surge, and frequent flooding. Chapter 1 uses quantitative climate data from a multitude of sources such as the New York State Department of Environmental Conservation'sreport on the “Impacts of Climate Change …

Book Review: Phenomena Of Power: Authority, Domination, And Violence, Kerri J. Malloy

Faculty Research, Scholarly, and Creative Activity

No abstract provided.

Gasdermins In Apoptosis: New Players In An Old Game., Corey Rogers, Emad S. Alnemri

Department of Biochemistry and Molecular Biology Faculty Papers

Apoptosis is a form of programmed cell death (PCD) that plays critical physiological roles in removing superfluous or dangerous cell populations that are unneeded or threatening to the health of the host organism. Although the molecular pathways leading to activation of the apoptotic program have been extensively studied and characterized starting in the 1970s, new evidence suggests that members of the gasdermin superfamily are novel pore-forming proteins that augment apoptosis by permeabilizing the mitochondria and participate in the final stages of the apoptotic program by inducing secondary necrosis/pyroptosis. These findings may explain outstanding questions in the field such as why …

Understanding The Role Of Anisotropy On The Optoelectronic And Colloidal Properties Of Quantum Rods For Programmable Self-Assembly With Dna Origami, Yuetian Chen

Dissertations - ALL

Semiconductor nanocrystals, like quantum dots (QDs) and quantum rods (QRs), have tunable optoelectronic properties that depend on their composition, size and asymmetry. A small change in size or aspect ratio can lead to measurable changes in optical absorption and photoluminescence emission energies, as well as varied degrees of polarized optical behaviors at those energies. My dissertation research focuses on investigating the role of anisotropy on the optoelectronic and colloidal properties of quantum rods, as well as using DNA-mediated self-assembly to align these quantum rods on DNA origami for energy transfer applications in biocompatible systems. First, CdSe of systematically varied aspect …

Novel Shape Memory And Multi-Shape Memory Polymers For Biomaterial Applications, Shelby Lois Buffington

Dissertations - ALL

Biomaterial platforms have been used to probe how cells respond to chemical, topographical or mechanical changes in their environments. However, these traditionally static biomaterial platforms have not enabled the study of how cells respond to dynamic changes in their environment. Driven by a need to better understand cell behavior and its role it disease, development and tissue regeneration recent efforts have focused on designing dynamic biomaterial platforms to better mimic a cell’s natural environment. In this work, advanced shape memory polymers (SMPs) that respond to non-thermal triggers and multi-shape memory materials capable of multiple topographical transitions were developed for advanced …

Network Sampling Through Crawling, Katchaguy Areekijseree

Dissertations - ALL

In recent years, researchers have increasingly used OSN data to study human behavior. Before such a study can begin, one must first obtain appropriate data. A platform, e.g, Facebook or Twitter, may provide an API for accessing data, but such APIs are often ratelimited, restricting the amount of data that an individual collects in a given amount of time. In order for the data collector to efficiently collect data, she needs to make intelligent use of her limited budget. Therefore, when collecting data, efficiency is extremely important. We consider the problem of network sampling through crawling, in which the data …