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2019

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Flexible Electrochemical Sensors Based On Iridium Oxide For Biomedical Applications, Xuesong Yang Aug 2019

Flexible Electrochemical Sensors Based On Iridium Oxide For Biomedical Applications, Xuesong Yang

Electrical Engineering Dissertations - Archive

Considering the disadvantages of the costly, laborious, and time-consuming traditional clinical analyses, there is a tendency of developing non-hospital point-of-care which allows patients to monitor their health conditions conveniently at home. To optimize the convenience of the point-of-care instruments, a wearable device with the ability of detecting different biological components in different biological conditions is preferer. The device should also have the qualities of rapid analyses, high accuracy, and high sensitivity. To accomplish these requirements, we proposed a flexible electrochemical sensor based on iridium oxide (IrOx). As a noble metal, iridium oxide has the advantages of bio-compatible, stable, and corrosive …

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Data-Driven Modeling Of Heterogeneous Multilayer Networks For Computing Communities Using Bipartite Graphs, Kanthi Sannappa Komar Aug 2019

Data-Driven Modeling Of Heterogeneous Multilayer Networks For Computing Communities Using Bipartite Graphs, Kanthi Sannappa Komar

Computer Science and Engineering Theses - Archive

Today, more than ever, data modeling and analysis play a vital role for enterprises in terms of finding actionable business intelligence. Data is being collected on a large scale from multiple sources hoping they can be leveraged using big data analysis techniques. However, challenges associated with the analysis of such data are numerous and depends on the characteristics of the data being collected. In many real-world applications, data sets are becoming complex as they are characterised by multiple entity types and multiple features (termed relationships) between entities. There is a need for an elegant approach to not only model such …

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The Effect Of Controlled Nanomaterial Deposition Towards Electrodes For Microbial Fuel Cells And Electrolysis Cells, Bryan Dennis Steinhoff Aug 2019

The Effect Of Controlled Nanomaterial Deposition Towards Electrodes For Microbial Fuel Cells And Electrolysis Cells, Bryan Dennis Steinhoff

Mechanical and Aerospace Engineering Dissertations - Archive

Microbial fuel cells (MFCs) and microbial electrolysis cells (MECs) are relatively new energy harvesting technologies that utilize the bacteria in wastewater or other organic-rich aqueous media to produce either electricity or hydrogen gas, respectively. Given that MFCs and MECs are newer technologies, there has been many works over the past two decades that have provided understanding into how modifying electrode surface chemistry can improve these cells. It has been widely known that increasing the surface functional groups of MFC anodes, either chemically or thermally, causes the cell power density to increase dramatically. Since MFCs and MECs use the same anodes, …

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Design And Optimization Of Additively Manufactured Heat Sink And Heat Spreader For Microelectronics Cooling, Aditya Krishna Ganesh Ram Aug 2019

Design And Optimization Of Additively Manufactured Heat Sink And Heat Spreader For Microelectronics Cooling, Aditya Krishna Ganesh Ram

Mechanical and Aerospace Engineering Theses - Archive

High performance cooling is a critical requirement for modern microprocessors that generate large amounts of non-uniformly distributed heat. Metal heat spreaders and heat sinks have been traditionally used for thermal management. While the design of these components has traditionallly been restricted by manufacturability, in recent years, additive manufacturing has offered the capability to manufacture almost any design. This work analyzes and optimizes the performance of an additively manufactured heat sink and heat spreader. Computational heat transfer simulations were carried out to understand the variation of chip temperature and pressure drop for various designs. Discussion of key findings include the thermal …

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Molecular Dynamics (Md) Thermal Simulations Of Molecular Bridging Across The Cathode-Separator Interface In Li-Ion Cell, Abhijeet Sundarrao Dhakane Aug 2019

Molecular Dynamics (Md) Thermal Simulations Of Molecular Bridging Across The Cathode-Separator Interface In Li-Ion Cell, Abhijeet Sundarrao Dhakane

Mechanical and Aerospace Engineering Theses - Archive

While Li-ion cells show outstanding electrochemical performance, their poor thermal transport characteristics results in reduced performance as well as significant safety concerns. The heterogeneous interface between cathode and separator plays a vital role in the dissipation of heat within a Li-ion cell. Previous studies showed that the cathode-separator interfacial thermal resistance contributes around 88% of total thermal resistance within the cell. In this research, thermal conductance across the cathode-separator interface is calculated using molecular dynamics simulations. Thermal transport in a pristine heterogeneous interface as well as interfaces functionalized with monolayers of APTES, nBTMS and MPTMS molecules is studied. The impact …

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Design, Development, And Validation Of A Novel Optical Imaging Device For Biomedical Applications, Ashley Christine Dacy Aug 2019

Design, Development, And Validation Of A Novel Optical Imaging Device For Biomedical Applications, Ashley Christine Dacy

Bioengineering Dissertations - Archive

Fluorescence and luminescence imaging are two promising optical techniques for diagnosing a variety of critical pathologies in vivo, including wound healing, inflammation, and vascular diseases. Despite this, there is a lack of imaging devices in research and commercially available that are capable of these imaging modalities in large animal applications. This work describes the progressive development of several optical imaging devices to fill this void, culminating in a final design with robust fluorescence and luminescence functionality designed for large animal and human applications. These devices are used to gather new data about various physical parameters in small and large animal …

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Ultrasound Switchable Fluorescence Imaging Based On A Time Gated Iccd Camera, Shuai Yu Aug 2019

Ultrasound Switchable Fluorescence Imaging Based On A Time Gated Iccd Camera, Shuai Yu

Bioengineering Dissertations - Archive

Ultrasound switchable fluorescence (USF) imaging has been proposed as a novel imaging modality which provides microscopic fluorescence imaging in centimeter-deep tissue. USF is possible to reveal many interesting phenomena such as microcirculation, tumor angiogenesis, and cancer metastasis and diagnose early-stage cancer. USF adopts a focused ultrasound (FU) to repetitively switch “on” fluorescent agents in tissue, and the USF photons scatter out and are captured by a detector. A USF image provides acoustic resolution and optical sensitivity. In USF, there are two key components: 1) an excellent USF contrast agent; and 2) a sensitive USF imaging system. The major challenge of …

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Lung Cancer Targeted Chemotherapy Via Herceptin Based Chimeric Antigen Receptor (Car) Engineered T Cell Membrane Coated Synthetic Nanoparticles, Serkan Yaman Aug 2019

Lung Cancer Targeted Chemotherapy Via Herceptin Based Chimeric Antigen Receptor (Car) Engineered T Cell Membrane Coated Synthetic Nanoparticles, Serkan Yaman

Bioengineering Dissertations - Archive

Cell membrane-derived nanoparticles recently caught attention due to their desirable features in drug delivery such as mimicking properties of native tissue and cells, avoiding systemic clearance, and alleviating foreign body responses. Besides nanoparticle technology, adoptive immunotherapy has emerged for its promising treatment modalities, including cancer specificity. Our long-term goal for this research is to develop a biomimetic drug carrier based on chimeric antigen receptor (CAR) transduced T cell membranes. In the study, anti-cancer drug afatinib loaded poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) co-extruded with anti her-2 based chimeric antigen receptor (CAR) Jurkat T cell membranes. Anti her-2 CAR-T cells were produced by …

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Development Of Medical Devices For Diagnosing Cartilage Injury And Metastatic Cancers, Yi Hui Huang Aug 2019

Development Of Medical Devices For Diagnosing Cartilage Injury And Metastatic Cancers, Yi Hui Huang

Bioengineering Dissertations - Archive

My research focused on applying biomedical engineering techniques to diagnose different diseases and conditions. The results of these work led to one published paper and two submitted manuscripts which are summarized in Chapters 2, 3 &4. Briefly, in Chapter 2, my work laid emphasis on developing a method for early detection of cartilage injury. An apoptotic cell-detecting probe was fabricated by the conjugation of the apoptotic cell-binding peptide (CQRPPR) and a sulfo-cyanine7 N-hydroxysuccinimide ester (Cy7 dye). Both in vitro and ex vivo examination showed an excellent relationship between the number of apoptotic chondrocytes and probe binding affinity. Finally, using a …

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Application Of Tissue Engineering Techniques For Treating Cartilage Injury And Diagnosing Cancer Metastasis, Amirhossein Hakamivala Aug 2019

Application Of Tissue Engineering Techniques For Treating Cartilage Injury And Diagnosing Cancer Metastasis, Amirhossein Hakamivala

Bioengineering Dissertations - Archive

This study focuses on the application of tissue engineering techniques for the diagnosis of cancer metastasis, cartilage regeneration, and modeling of lymph node metastasis. Chapter 1 is an overview of tissue engineering strategies, and it describes how each chapter relates to the central theme. Chapter 2 describes the development of 3D lymph node (LN) mimetic for studying prostate cancer metastasis. The overall objective of this chapter was to develop a biosystem with the ability to mimic metastatic LN condition. Studies were first designed to uncover the critical cells types and chemokines responsible for cancer metastasis to the LNs. An LN …

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Development Of An In Vitro Tbi Models And Validation Of Nanodelivery For Restoration Of Disrupted Brain Endothelium, Edidiong I. Inyang Aug 2019

Development Of An In Vitro Tbi Models And Validation Of Nanodelivery For Restoration Of Disrupted Brain Endothelium, Edidiong I. Inyang

Bioengineering Dissertations - Archive

Blast-induced traumatic brain injury (bTBI) is a serious concern among military personnel and their families. Although the mechanisms responsible for disruption to the brain are not well understood, the development of reliable diagnosis along with effective therapeutic treatment is urgently warranted. Recent findings suggest that shockwaves produced by a blast can generate micron-size bubbles that subsequently collapse in the brain tissue. The collapse of microbubbles (referred to as microcavitation) may compromise the integrity of the blood-brain barrier (BBB). Moreover, addiction to the psycho-stimulant drugs (PSDs), e.g. cocaine and alcohol which are known to cause toxicity due to oxidative stress, can …

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Evaluation And Prediction Of Energy Potential Of Landfill Mined Solid Waste, Rakib Ahmed Aug 2019

Evaluation And Prediction Of Energy Potential Of Landfill Mined Solid Waste, Rakib Ahmed

Civil Engineering Dissertations - Archive

Landfilling is the most popular waste disposal system worldwide; however, with increasing scarcity of materials, increases in land values, and the presence of non-engineered landfill sites in both the developing and developed world, landfill mining has been the recipient of special interest in today’s waste management practices. Therefore, the motivation of the current study was to evaluate the energy potential of mined landfill waste and develop a statistically significant mathematical model to predict its energy potential (calorific value). The current study was conducted by using the municipal solid waste (MSW) samples collected from the City of Denton landfill and the …

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Functional Analysis Of Nuclear-Encoded Mitochondrial Gene Duplicates With Testis-Biased Expression In Drosophila Melanogaster, Mohammadmehdi M. Eslamieh Aug 2019

Functional Analysis Of Nuclear-Encoded Mitochondrial Gene Duplicates With Testis-Biased Expression In Drosophila Melanogaster, Mohammadmehdi M. Eslamieh

Biology Dissertations - Archive

Most of the genes encoding proteins that function in the mitochondria are located in the nucleus and are called nuclear-encoded mitochondrial genes (N-mt genes). In Drosophila melanogaster, most of the tissue-specific duplicated N-mt genes have acquired testis-biased expression. These genes appear to be older and relocated more often than other duplicated genes and have energy-related functions. These patterns reveal strong selection for the retention of new genes for male germline mitochondrial functions. Maternal inheritance of mitochondria and male-male competition for fertilization are two common forces that might drive changes in mitochondrial functions. We analyzed N-mt genes in the human genome …

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Stress Responses Of Corals And Their Symbiotic Partners, Contessa A. Ricci Aug 2019

Stress Responses Of Corals And Their Symbiotic Partners, Contessa A. Ricci

Biology Dissertations - Archive

Disease and temperature are primary threats to coral persistence, and these stresses can work synergistically to accelerate coral declines. In the face of climate change, understanding the effects of these stresses is key to understanding ecosystem services of future reefs. Corals are an amalgam of the coral animal, an intracellular dinoflagellate symbiont (family Symbiodiniaceae), and a consortium of other symbiotic microbes that exist in the coral surface mucus layer. As such, it is important to consider the role of each component. It is also important to view any coral study through the lens of immunity, as the existence of these …

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The Effects Of Oil On Blue Crab And Periwinkle Snail Interactions: A Mesocosm Study, Elizabeth M. Robinson, Nancy N. Rabalais Aug 2019

The Effects Of Oil On Blue Crab And Periwinkle Snail Interactions: A Mesocosm Study, Elizabeth M. Robinson, Nancy N. Rabalais

Faculty Publications

We examined the sub-lethal effect of Macondo oil from the Deepwater Horizon oil spill on predator-prey interactions using blue crabs (Callinectes sapidus) and periwinkle snails (Littoraria irrorata). A 2 x 2 factorial mesocosm design determined the effect of oil (no oil vs. oil) and blue crabs (no blue crab predator vs. one blue crab predator) on periwinkle snail climbing and survival. Sixteen mesocosm tanks were used in the experiment, which were replicated three times. Each tank contained water, sand, and Spartina marsh stems. The sixteen tanks were divided between two, temperature-controlled chambers to separate oil treatments (no oil vs. oil). …

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Factors Influencing Blue Carbon Accumulation Across A 32‐Year Chronosequence Of Created Coastal Marshes, Katherine M. Abbott, Tracy Elsey‐Quirk, Ronald D. Delaune Aug 2019

Factors Influencing Blue Carbon Accumulation Across A 32‐Year Chronosequence Of Created Coastal Marshes, Katherine M. Abbott, Tracy Elsey‐Quirk, Ronald D. Delaune

Faculty Publications

No abstract provided.

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Development Of Methods Of Treatment Of Medical Waste In The Hospitals Of Baghdad Health Department / (Rusafa Survey), Kareem Bahr Nadah Aug 2019

Development Of Methods Of Treatment Of Medical Waste In The Hospitals Of Baghdad Health Department / (Rusafa Survey), Kareem Bahr Nadah

Journal of Economics and Administrative Sciences

Purpose: To contribute to the development of an appropriate program for the management of medical waste based on clear-cut principles in order to reach the overall goal of improving the public health and environment of the population in our country. Design / Approach / Introduction: The research is based on the analytical descriptive approach as a method of study in the field of data collection using a check list and analysis of the data through the use of some statistical treatments. Results: The need is to establish a medical waste management in hospitals and follow international standards in all stages …

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Spatial Variability Of Mangrove Primary Productivity In The Neotropics, Rafaela De Albuquerque Ribeiro, André Scarlate Rovai, Robert R. Twilley, Edward Castañeda-Moya Aug 2019

Spatial Variability Of Mangrove Primary Productivity In The Neotropics, Rafaela De Albuquerque Ribeiro, André Scarlate Rovai, Robert R. Twilley, Edward Castañeda-Moya

Faculty Publications

Mangroves are considered one of the most productive ecosystems in the world with significant contributions as carbon sinks in the biosphere. Yet few attempts have been made to assess global patterns in mangrove net primary productivity, except for a few assumptions relating litterfall rates to variation in latitude. We combined geophysical and climatic variables to predict mangrove litterfall rates at continental scale. On a per-area basis, carbon flux in litterfall in the neotropics is estimated at 5 MgC·ha−1·yr−1, between 20% and 50% higher than previous estimates. Annual carbon fixed in mangrove litterfall in the neotropics is …

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Proteomic Evaluation And Cytotoxicity Of Red Maple (Acer Rubrum) Leaves, Saud Alshammari Aug 2019

Proteomic Evaluation And Cytotoxicity Of Red Maple (Acer Rubrum) Leaves, Saud Alshammari

Pharmaceutical Sciences (MS) Theses

Red maple (Acer rubrum), also known as swamp, water or soft maple, is endemic to eastern and central North America and was widely used as traditional medicine by the first peoples. Commercially, its well-known products include maple syrup and high-quality lumber. The potential medicinal benefits of phenolic compounds extracted from the red maple plant, such as glucitol-core containing gallotannins, include antioxidant, and antiglycation effects as well as their importance in cosmetic applications. Plant-derived proteins and peptides are important biomolecules; however to date, there is no published data on the identification of proteins/peptides from red maple leaves. Therefore, the …

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Altering The Regiospecificity Of C6 Indole Prenyltransferase Enzymes Towards Drug Development, Ahmed R. Aoun Aug 2019

Altering The Regiospecificity Of C6 Indole Prenyltransferase Enzymes Towards Drug Development, Ahmed R. Aoun

Pharmaceutical Sciences (MS) Theses

Prenyltransferase (PT) biocatalysts are late-stage tailoring enzymes that modify natural products. PTs catalyze the attachment of prenyl moieties to natural product acceptors using pyrophosphate donors. This prenyl modification in small molecules leads to changes in structural and biological activities. Understanding the structural insights as well as the mechanisms by which PTs function allows us to utilize PTs as a unique approach towards drug development. PriB PT is an example of aromatic PTs that has been characterized previously as a L-tryptophan (L-Trp) C6 C-prenyltransferase (C6-C-PT). Analysis of PriB binding pocket, highlighted key residues that might play an important …

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Cancer Cell Population Growth Kinetics At Low Densities Deviate From The Exponential Growth Model And Suggest An Allee Effect., Kaitlyn E Johnson, Grant Howard, William Mo, Michael K Strasser, Ernesto A B F Lima, Sui Huang, Amy Brock Aug 2019

Cancer Cell Population Growth Kinetics At Low Densities Deviate From The Exponential Growth Model And Suggest An Allee Effect., Kaitlyn E Johnson, Grant Howard, William Mo, Michael K Strasser, Ernesto A B F Lima, Sui Huang, Amy Brock

Articles, Abstracts, and Reports

Most models of cancer cell population expansion assume exponential growth kinetics at low cell densities, with deviations to account for observed slowing of growth rate only at higher densities due to limited resources such as space and nutrients. However, recent preclinical and clinical observations of tumor initiation or recurrence indicate the presence of tumor growth kinetics in which growth rates scale positively with cell numbers. These observations are analogous to the cooperative behavior of species in an ecosystem described by the ecological principle of the Allee effect. In preclinical and clinical models, however, tumor growth data are limited by the …

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Sensory Primary Cilium Is A Distinct Signaling Compartment, Rinzhin Tshering Sherpa Aug 2019

Sensory Primary Cilium Is A Distinct Signaling Compartment, Rinzhin Tshering Sherpa

Pharmaceutical Sciences (PhD) Dissertations

The primary cilium is a solitary cellular organelle that protrudes from the apical cell membrane. Findings on cilia-dependent mechanosenstation have shown that the primary cilium acts as a transducer of fluid-shear stress into intracellular signaling. Over recent years, studies in primary cilia have intensified after determining a causal relationship between dysfunctional primary cilia and cystic diseases. Along with its mechanosensory function, the primary cilium houses a variety of receptors, ion channels and transporter proteins. Studies in cilia biology have shown that primary cilia are coordinators of signaling pathways such as Hedgehog (Hh), Wnt, and platelet-derived growth factor (PDGF) pathways during …

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Learning For Clinical Outcome Prediction From Big Medical Data, Jiawen Yao Aug 2019

Learning For Clinical Outcome Prediction From Big Medical Data, Jiawen Yao

Computer Science and Engineering Dissertations - Archive

With the advance of recent technological innovations, nowadays scientists can easily capture and store tremendous amounts of different types of medical data such as Computed Tomography (CT), Magnetic Resonance Imaging (MRI), big pathological images and high dimensional cell profiling data. Developing deep learning and machine learning to analyze such large-scale medical data sets for patient health care is an interesting but challenging problem. Inspired by the trend, in this dissertation, we focus on solving real-world problems, like survival analysis on image-omics data and reducing uncertainty from undersampled MRI. Survival analysis is a crucial tool in the clinical study of cancer …

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Early Progression To Active Tuberculosis Is A Highly Heritable Trait Driven By 3q23 In Peruvians, Yang Luo, Sara Suliman, Samira Asagari, Tiffany Amariuta, Yuriy Baglaenko, Marta Martinez-Bonet, Kazuyoshi Ishigaki, Maria Gutierrez-Arcelus, Roger Calderon, Jerome Galea Aug 2019

Early Progression To Active Tuberculosis Is A Highly Heritable Trait Driven By 3q23 In Peruvians, Yang Luo, Sara Suliman, Samira Asagari, Tiffany Amariuta, Yuriy Baglaenko, Marta Martinez-Bonet, Kazuyoshi Ishigaki, Maria Gutierrez-Arcelus, Roger Calderon, Jerome Galea

Social Work Faculty Publications

Of the 1.8 billion people worldwide infected with Mycobacterium tuberculosis, 5–15% will develop active tuberculosis (TB). Approximately half will progress to active TB within the first 18 months after infection, presumably because they fail to mount an effective initial immune response. Here, in a genome-wide genetic study of early TB progression, we genotype 4002 active TB cases and their household contacts in Peru. We quantify genetic heritability hg2 of early TB progression to be 21.2% (standard error 0.08). This suggests TB progression has a strong genetic basis, and is comparable to traits with well-established genetic bases. We …

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Violation Of Electrostatic Rules: Shifting Balance Between Pnicogen Bond And Lone Pair−Π Interaction Tuned By Substituents, Zongqing Chi, Tong Yan, Qing-Zhong Li, Steve Scheiner Aug 2019

Violation Of Electrostatic Rules: Shifting Balance Between Pnicogen Bond And Lone Pair−Π Interaction Tuned By Substituents, Zongqing Chi, Tong Yan, Qing-Zhong Li, Steve Scheiner

Chemistry and Biochemistry Faculty Publications

Complexes were formed pairing ZCl3 (Z=P, As, Sb) with C2R4 (R= H, F, CN). The first interaction present is a pnicogen bond between the Z atom and the C=C π-bond. This bond weakens as the H atoms of ethylene are replaced by electron-withdrawing F and CN and the potential above the alkene switches from negative to positive. In the latter two cases, another set of noncovalent bonds is formed between the Cl lone pairs of ZCl3 and the π*(C=C) antibonding orbital, as well as with the F or CN substituents. The growing strength of these interactions, coupled with a large …

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Reforming The Rehabilitation Process Of Incarcerated Females Affected By Sexual Trauma, Tamnika Walton Aug 2019

Reforming The Rehabilitation Process Of Incarcerated Females Affected By Sexual Trauma, Tamnika Walton

2019 Fall Honors Capstone Projects - Archive

Sexual trauma has been found to affect individuals across all socioeconomic lines. For some, recovery from the damages is a process that often includes bouts with the justice system that ends in one or more imprisonment terms. Often these prison sentences are caused by substance use and sex industry crimes. The study shows that the time these women are serving is often a result of the trauma they have faced either by childhood sexual abuse (CSA), domestic sex trafficking (DST), or sexual violence as an adult. The purpose of the study is to determine if incarcerated women who have suffered …

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Agricultural Drought Assessment Based On Multiple Soil Moisture Products, Jongjin Baik, Muhammad Zohaib, Ungtae Kim, Muhammad Aadil, Minha Choi Aug 2019

Agricultural Drought Assessment Based On Multiple Soil Moisture Products, Jongjin Baik, Muhammad Zohaib, Ungtae Kim, Muhammad Aadil, Minha Choi

Civil and Environmental Engineering Faculty Publications

In this study, we evaluated three soil moisture (SM) products (Advanced Microwave Scanning Radiometer-2 [AMSR2], Advanced SCATterometer [ASCAT], and European Reanalysis Interim [ERA-interim]) across Australia in four climate zones by comparing against the Australian Water Resources Assessment-Landscape (AWRA-L) SM products from July 2012 to June 2017. The ASCAT SM indicated better performance than other SM products over Australia. To evaluate the applicability and reliability for monitoring agricultural drought, an agricultural drought index, the Soil Water Deficit Index, was estimated from three SM products and compared with three commonly-used drought indices (atmospheric water deficit [AWD], Evaporative Stress Index, and Reconnaissance …

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Remaining Service Life Estimation And Probabilistic Analysis Of Reinforced Concrete Sewer Pipeline Systems, Pardis Moamaei Aug 2019

Remaining Service Life Estimation And Probabilistic Analysis Of Reinforced Concrete Sewer Pipeline Systems, Pardis Moamaei

Civil Engineering Theses - Archive

The serviceability and structural performance of reinforced concrete pipes could deteriorate for many reasons. The loss in structural capacity and other structural operations may drastically affect the surrounding environment, public health and the economy. This research is directed towards the estimation of remaining service life, and to evaluate the level of risk of failure of reinforced concrete sewer pipes (RCSP) that are subjected to continuing corrosion due to sulfide attack that in turn leads to loss of pipe thickness caused by excessive deterioration along the pipe’s interior wall. In order to estimate the remaining service life, reliability theory is used …

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Depression Screening And Treatment Among Disparity Populations In Primary Care: A Retrospective Analysis Of Electronic Health Records Data, Afsaneh Rezaeizadeh Aug 2019

Depression Screening And Treatment Among Disparity Populations In Primary Care: A Retrospective Analysis Of Electronic Health Records Data, Afsaneh Rezaeizadeh

Social Work Theses - Archive

Depression is a common and costly chronic medical illness seen in health care settings, including primary care. Disparity populations in community settings are at risk for depression, but less likely to seek treatment for symptoms. This paper explores the screening, diagnosis, treatment, and follow-up patterns of depression in nine community clinics throughout North Texas. A retrospective study design was used to analyze electronic health record data in 2017. A total of 11,803 patients visited nine community care clinics in 2017. PHQ-2 counts were collected to assess for screening rates, while PHQ-9 counts were collected to assess for follow-up rates in …

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The Roles Of Long Noncoding Rnas In Inflammation And Immune Responses, Monira Obaid Aug 2019

The Roles Of Long Noncoding Rnas In Inflammation And Immune Responses, Monira Obaid

Chemistry & Biochemistry Dissertations - Archive

Inflammation is an immune response that protects the human body from infection, illness, or injury. The inflammatory response causes the activation of immune cells, such as leukocyte subsets (i.e., monocytes, macrophages, dendritic cells, neutrophils, eosinophils and others), T cells, and B cells, and induces production of inflammatory mediators such as cytokines, chemokines, and antibodies to fight against injury or infection. Uncontrolled and continued inflammation drives the development of many human diseases, including metabolic diseases, obesity, diabetes, autoimmune disorders, neurological disorder and cancer. Indeed, the signaling process associated with inflammation and immune response is very complex. Our understanding of inflammation and …

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