Digital Commons Network^™

Epigenetic Regulation On Plant Stress Memory, Febri Adi Susanto

International Programs

Plants are sessile organisms; they cannot move like animals when the environment is not favorable. Therefore, plants need a mechanism to cope with environmental changes. For example, when a plant experiences stress, like water deficit, it will employ a certain mechanism that allows the plant to survive the next exposure (see Fig. 1), often referred to as “Epigenetic” regulation. By application, epigenetics deals with the changes of the level of the gene expression without change in the DNA sequence, by DNA methylation, histone modifications, and or small RNA regulation. Plant epigenetic regulation is related to the Lamarckian theory of evolution. …

Fy19 Final Report | Scholarship & Innovation: An Inquiry 2018-2019, José M. Torres, Kelly Page, Amber Stitziel Pareja, Jean Bigger, Richard Palmer, Lindsey Herlehy, Richard Schultz, Nadia Miskowiec

Scholarship & Innovation Committee

The IMSA Scholarship and Innovation Committee was established in August, 2019 by Dr. José Torres based on report recommendations from Research Fellow, Dr. Page as a way to deepen a culture of scholarship, research and innovation across the IMSA community. The purpose of the committee is to create and communicate a shared vision, meaning and support for scholarship and innovation at IMSA, continuing its long tradition as a leading learning laboratory.

Jane’S Urban Ethics: Jane Jacobs On Racism, Capital, Power, And The Plantation Mentality Peter L. Laurence, Peter L. Laurence

Publications

The 2016 centennial of Jane Jacobs's birth was an opportunity for scholars and pundits to reflect on the legacy of The Death and Life of Great American Cities and the author's other works and activism. Such reflections naturally reflected on her enduring appeal and readership, but also sought to find shortcomings. Among the critics, and even some otherwise admiring biographers, was a theme that while Jacobs was keen to observe the importance of “eyes on the street” and other street-scaled phenomena, she was weak on such overarching structural concerns as racism, power, and capital. From such charges arose claims that …

Utah State Magazine, Fall 2019, Utah State University

Utah State Magazine

The quarterly magazine for friends and alumni of Utah State University.

Rb1 Deletion In Retinoblastoma Protein Pathway-Disrupted Cells Results In Dna Damage And Cancer Progression, Aren E. Marshall, Michael V. Roes, Daniel T. Passos, Megan C. Deweerd, Andrea C. Chaikovsky, Julien Sage, Christopher J. Howlett, Frederick A. Dick

Paediatrics Publications

Proliferative control in cancer cells is frequently disrupted by mutations in the retinoblastoma protein (RB) pathway. Intriguingly, RB1 mutations can arise late in tumorigenesis in cancer cells whose RB pathway is already compromised by another mutation. In this study, we present evidence for increased DNA damage and instability in cancer cells with RB pathway defects when RB1 mutations are induced. We generated isogenic RB1 mutant genotypes with CRISPR/Cas9 in a number of cell lines. Cells with even one mutant copy of RB1 have increased basal levels of DNA damage and increased mitotic errors. Elevated levels of reactive oxygen species as …

Methodological Consensus On Clinical Proton Mrs Of The Brain: Review And Recommendations, Martin Wilson, Ovidiu Andronesi, Peter B. Barker, Robert Bartha, Alberto Bizzi, Patrick J. Bolan, Kevin M. Brindle, In Young Choi, Cristina Cudalbu, Ulrike Dydak, Uzay E. Emir, Ramon G. Gonzalez, Stephan Gruber, Rolf Gruetter, Rakesh K. Gupta, Arend Heerschap, Anke Henning, Hoby P. Hetherington, Petra S. Huppi, Ralph E. Hurd, Kejal Kantarci, Risto A. Kauppinen, Dennis W.J. Klomp, Roland Kreis, Marijn J. Kruiskamp, Martin O. Leach, Alexander P. Lin, Peter R. Luijten, Małgorzata Marjańska, Andrew A. Maudsley, Dieter J. Meyerhoff, Carolyn E. Mountford

Medical Biophysics Publications

© 2019 International Society for Magnetic Resonance in Medicine Proton MRS (1H MRS) provides noninvasive, quantitative metabolite profiles of tissue and has been shown to aid the clinical management of several brain diseases. Although most modern clinical MR scanners support MRS capabilities, routine use is largely restricted to specialized centers with good access to MR research support. Widespread adoption has been slow for several reasons, and technical challenges toward obtaining reliable good-quality results have been identified as a contributing factor. Considerable progress has been made by the research community to address many of these challenges, and in this paper a …

Traffic Noise And Sexual Selection: Studies Of Anthropogenic Impact On Bird Songs And Undergraduate Student Reasoning Of Evolutionary Mechanisms, Sarah Spier

School of Natural Resources: Dissertations, Theses, and Student Research

Humans have transformed much of the natural landscape and are continuing to do so at an accelerated rate, compromising natural areas that serve as important habitat for many species. Roads impact much of the environment as they fragment habitat and introduce traffic noise into the acoustic environment, deferentially affecting wildlife in roadside habitat. I explored how traffic noise affects the detection of birds based on whether their vocalizations were masked by traffic noise. Masked species detection was not affected by an increase in traffic noise amplitude, while there was a negative effect of traffic noise amplitude on unmasked species detection, …

Traffic Noise And Sexual Selection: Studies Of Anthropogenic Impact On Bird Songs And Undergraduate Student Reasoning Of Evolutionary Mechanisms, Sarah Spier

School of Natural Resources: Dissertations, Theses, and Student Research

Humans have transformed much of the natural landscape and are continuing to do so at an accelerated rate, compromising natural areas that serve as important habitat for many species. Roads impact much of the environment as they fragment habitat and introduce traffic noise into the acoustic environment, deferentially affecting wildlife in roadside habitat. I explored how traffic noise affects the detection of birds based on whether their vocalizations were masked by traffic noise. Masked species detection was not affected by an increase in traffic noise amplitude, while there was a negative effect of traffic noise amplitude on unmasked species detection, …

A Flavor Perception Game Designed To Introduce Basic Chemical Sensation Of Taste Modalities To Undergraduate Nursing And Exercise Sciences Students, Angela L. Mahaffey

Nursing: School of Nursing Faculty Publications and Other Works

The Flavor Perception Game was designed with the goals of developing an interactive and hands-on activity, providing a platform to review chemical senses of the five tastes, promoting student investment in the course material, and providing a basis for discussion on chemical senses of the five tastes. Knowledge of taste sensation is useful for nursing and exercise sciences students, as human physiology is integral to both baccalaureate curricula. The game is inexpensive, easy to incorporate into a 50-minute lecture period, and free of chocolate allergens. Student participants (N=34) tasted three candies and completed a voluntary anonymous poll regarding their detection …

The Effect Of Lateral Deviation On Triple Jump Performance, Kourtney Symone Jones

Master's Theses

Field events in track and field consist of throws (e.g., hammer, shot put, discus, javelin), vertical jumps (e.g., pole vault, high jump), and horizontal jumps (e.g., long jump, triple jump). Of the two horizontal jumps, triple jump is the most complex consisting of three phases: hop, step, and jump. Research has been conducted to examine limb motion and phasing distribution during triple jump performance; however, the effect of lateral deviation on triple jump performance in unknown. Purpose: The purpose of this study is 1) to determine the effect of lateral deviation on total triple jump performance within high school triple …

Mysci: A New Approach To Teaching Biological Science Laboratories, Korli Alford

Master's Theses

According to the National Science Foundation’s report “Vision and Change in Undergraduate Biology Education: A Call to Action,” project-based learning creates effective graduates and future collaborators. Instructors who are able to adapt their course to meet the unique interests of their students create graduates who are more likely to engage with peers and to retain the information taught throughout the class. The goal of this project was to develop a course based on student-driven, evidence-based learning. Five major and 12 minor, student-selectable labs were implemented in the initial test reported herein. A total of seven undergraduate students and three graduate …

Studies On Pathogenesis Of The Diseases Caused By Macrophomina Phaseolina And Phomopsis Longicolla On Soybean, Marcio Leizer Zaccaron

Graduate Theses and Dissertations

Soybean (Glycine max), a legume, is an economically important crop in many parts of the world, including the USA, Brazil, Argentina, China, and India, currently the top five producing countries. Soybean is primarily used as feed, with incising markets for food and biodiesel. Similar to most crops, soybean yield and quality are affected by a diverse group of plant pathogens. In particular, several species of filamentous fungi have been the cause of severe yield losses in most growing regions world-wide. The soil born fungus Macrophomina phaseolina, causal agent of charcoal rot, has been found to be endemic to several soybean …

Microextrusion 3d Printing Of Optical Waveguides And Microheaters, Edidiong Nseowo Udofia

Graduate Theses and Dissertations

The drive for smaller and more compact devices presents several challenges in materials and fabrication strategies. Although photolithography is a well-developed method for creating microdevices, the disparate requirements in fabrication strategies, material choices, equipment and process complexities have limited its applications. Microextrusion printing (μEP) provides a promising alternative for microfabrication. Compared to the traditional techniques, the attractions lie in the wide range of printable material choice, greater design freedom, fewer processing steps, lower cost for customized production, and the plurality of compatible substrates. However, while extrusion-based 3D printing processes have been successfully applied at the macroscale, this seeming simplicity belies …

Meox2 Haploinsufficiency Accelerates Axonal Degeneration In Dba/2j Glaucoma., Rebecca A Buchanan, Kate E Foley, Keating W. Pepper, Alaina M Reagan, Kelly J Keezer, Amanda A Hewes, Cory A Diemler, Christoph Preuss, Ileana Soto, Simon W M John, Gareth R Howell

Faculty Research 2019

Purpose: Glaucoma is a complex disease with major risk factors including advancing age and increased intraocular pressure (IOP). Dissecting these earliest events will likely identify new avenues for therapeutics. Previously, we performed transcriptional profiling in DBA/2J (D2) mice, a widely used mouse model relevant to glaucoma. Here, we use these data to identify and test regulators of early gene expression changes in DBA/2J glaucoma.

Methods: Upstream regulator analysis (URA) in Ingenuity Pathway Analysis was performed to identify potential master regulators of differentially expressed genes. The function of one putative regulator, mesenchyme homeobox 2 (Meox2), was tested using a combination of …

Rapid Growth Is A Dominant Predictor Of Hepcidin Suppression And Declining Ferritin In Gambian Infants., Andrew E Armitage, Schadrac C Agbla, Modupeh Betts, Ebrima A Sise, Momodou W Jallow, Ellen Sambou, Bakary Darboe, Archibald Worwui, George M. Weinstock, Martin Antonio, Sant-Rayn Pasricha, Andrew M Prentice, Hal Drakesmith, Momodou K Darboe, Brenda Anna Kwambana-Adams

Faculty Research 2019

Iron deficiency and iron deficiency anemia are highly prevalent in low-income countries, especially among young children. Hepcidin is the major regulator of systemic iron homeostasis. It controls dietary iron absorption, dictates whether absorbed iron is made available in circulation for erythropoiesis and other iron-demanding processes, and predicts response to oral iron supplementation. Understanding how hepcidin is itself regulated is therefore important, especially in young children. We investigated how changes in iron-related parameters, inflammation and infection status, seasonality, and growth influenced plasma hepcidin and ferritin concentrations during infancy using longitudinal data from two birth cohorts of infants in rural Gambia (n=114 …

The Effect Of Conversational Agent Skill On User Behavior During Deception, Ryan M. Schuetzler, G. Mark Grimes, Justin Scott Giboney

Information Systems and Quantitative Analysis Faculty Publications

Conversational agents (CAs) are an integral component of many personal and business interactions. Many recent advancements in CA technology have attempted to make these interactions more natural and human-like. However, it is currently unclear how human-like traits in a CA impact the way users respond to questions from the CA. In some applications where CAs may be used, detecting deception is important. Design elements that make CA interactions more human-like may induce undesired strategic behaviors from human deceivers to mask their deception. To better understand this interaction, this research investigates the effect of conversational skill—that is, the ability of the …

Measurement Repeatability Of 18 F-Fdg Pet/Ct Versus 18 F-Fdg Pet/Mri In Solid Tumors Of The Pelvis, Tyler J Fraum, Kathryn J Fowler, John P Crandall, Richard A Laforest, Amber Salter, Hongyu An, Michael A Jacobs, Perry W Grigsby, Farrokh Dehdashti, Richard L Wahl

Open Access Publications

Knowledge of the within-subject variability of

Fqstat: A Parallel Architecture For Very High-Speed Assessment Of Sequencing Quality Metrics, Sree K. Chanumolu, Mustafa Albahrani, Hasan H. Otu

Department of Electrical and Computer Engineering: Faculty Publications

Background: High throughput DNA/RNA sequencing has revolutionized biological and clinical research. Sequencing is widely used, and generates very large amounts of data, mainly due to reduced cost and advanced technologies. Quickly assessing the quality of giga-to-tera base levels of sequencing data has become a routine but important task. Identification and elimination of low-quality sequence data is crucial for reliability of downstream analysis results. There is a need for a high-speed tool that uses optimized parallel programming for batch processing and simply gauges the quality of sequencing data from multiple datasets independent of any other processing steps.

Results: FQStat is a …

Women’S Right And Education In Saudi Arabia: Raising Critical Consciousness In Arabic Studies Courses In Female High Schools In Saudi Arabia, Eman Almutairi

Education (PhD) Dissertations

This is a qualitative research study that investigated the understanding of the concept of “critical consciousness” by female teachers teaching Arabic in Saudi Arabia’s high schools, the opportunity they have to develop critical consciousness, and how and why they develop it. The researcher engaged in semi-structured interviews with 25 female teachers who have at least nine years teaching experiences. The findings revealed that these teachers: (a) have a collective sense of the importance of critical consciousness skills to better themselves and Saudi Arabian society; (b) they are interested in and motivated to develop their critical thinking skills; (c) they develop …

Organically Modified Inorganic Nanoparticles For Halochromic Ionophores And Nucleic Acids, William Johnston

Doctoral Dissertations

In this dissertation, four nanoparticle reaction schemes were developed as substrates for halochromic dyes or nucleic acids. The reaction schemes include the use of two substrates: silica nanoparticles and halloysite nanotubes. The protocols can incorporate silica (SiO2) nanoparticles and halloysite aluminosilicate (AlO2SiO2) nanotubes due to the presence of silane groups on the surface of either substrate. The reaction schemes are presented along with detailed protocols which were written to facilitate both reproducibility and to serve as an aid to further study and for easy modification of the protocol to suit a researcher's needs. The data is discussed in the materials …

Students Of Size: An Exploratory Case Study On A Hidden Climate, Braelin Pantel

Dissertations

Colleges and universities often espouse values related to equity and inclusion for diverse students (Harper & antonio, 2008; Torres, Arminio, & Pope, 2012;). Student affairs practitioners are frequently responsible for working towards inclusive environments (American College Personnel Association (ACPA), & National Association of Student Personnel Administrators (NASPA), 2015). An estimated 31% of college and university students are classified as overweight or obese (American College Health Association, 2007), yet body weight or size is rarely a consideration in work related to student equity and inclusion on campus. Limited research exists on the experiences of students of size in college and university …

Group Differences In Motivation And Achievement Outcomes Within A First-Year Seminar, Selani D. Flores

Dissertations

This intervention study explored potential motivation, achievement, and gender differences among students within an existing first-year program (n = 388). This intervention program (FYE 101) was chosen because it has a diverse population and a large number of underserved students, it fosters content that is grounded in motivational research, and it has had a positive impact on increased student GPA and fall-to-fall persistence. Prior research showed that FYE 101 was effective in mitigating academic outcomes for students within the course when compared to students who did not participate, however, we do not know if it would be equally effective for …

Design, Microfabrication And Characterization Of Concentric Gold Nanoring Electrode For Neurochemical Sensing, Haocheng Yin

Doctoral Dissertations

Nanoelectrodes have become widely used in electrochemical sensing in recent decades. When compared to microelectrodes, it has many unique advantages such as high signal to noise ratio, small sample volume requirement, and lower detection limits.

This work reports on the microfabrication and characterization of a gold nanoring electrode (Au NRE) patterned on top of a silicon (Si) micropillar. An NRE of 165  10 nm in width was micropatterned on 4.6  1 µm diameter  17.5  2.5 µm long Si micropillar with an intervening 50 nm thick hafnium oxide insulating layer. Scanning electron microscopy and energy dispersive spectroscopy …

Study On Microwave Sterilization Technology Of Humidifier In Central Air Conditioning System, Yang Lv, Guangyao Hu, Jingyi Liang, Xi Chen, Bin Chen, Tongke Zhao, Xiaoying Lu, Bin Wang, Wenjie Yuan, Yimin Li

Faculty of Science & Technology (THEi)

© 2019 The issue of fungal microbial contamination in central air conditioning systems is one of the main problems of biological pollution in building environment. In this study, through the basic experimental study of microwave sterilization under ideal conditions, considering the sterilization effect and energy consumption, the preliminary reference range of microwave sterilization effective temperature is 50°C–59 °C. Through the research of microwave sterilization experimental platform of humidifier in central air conditioning system, it is found that microwave sterilization has a slight influence on the air supply parameters of air conditioning system, and it can be considered under the operating …

Post–Modern Epidemiology: When Methods Meet Matter, George Davey Smith

United States Public Health Resources

In the last third of the 20th century, etiological epidemiology within academia in high-income countries shifted its primary concern from attempting to tackle the apparent epidemic of noncommunicable diseases to an increasing focus on developing statistical and causal inference methodologies. This move was mutually constitutive with the failure of applied epidemiology to make major progress, with many of the advances in understanding the causes of noncommunicable diseases coming from outside the discipline, while ironically revealing the infectious origins of several major conditions. Conversely, there were many examples of epidemiologic studies promoting ineffective interventions and little evident attempt to account for …

Durvalumab In Combination With Olaparib In Patients With Relapsed Sclc: Results From A Phase Ii Study, Anish Thomas, Rasa Vilimas, Christopher Trindade, Rebecca Erwin-Cohen, Nitin Roper, Liqiang Xi, Venkatesh Krishnasamy, Elliot Levy, Andy Mammen, Samantha Nichols, Yuanbin Chen, Vamsidhar Velcheti, Faye Yin, Eva Szabo, Yves Pommier, Seth M. Steinberg, Jane B. Trepel, Mark Raffeld, Howard A. Young, Javed Khan, Stephen Hewitt, Jung Min Lee

United States Public Health Resources

Purpose: Despite high tumor mutationburden, immune checkpoint blockade has limited efficacy in SCLC. We hypothesized that poly (ADP-ribose) polymerase inhibition could render SCLC more susceptible to immune checkpoint blockade. Methods: A single-arm, phase II trial (NCT02484404) enrolled patients with relapsed SCLC who received durvalumab, 1500 mg every 4 weeks, and olaparib, 300 mg twice a day. The primary outcome was objective response rate. Correlative studies included mandatory collection of pretreatment and during-treatment biopsy specimens, which were assessed to define SCLC immunephenotypes: desert (CD8-positive T-cell prevalence low), excluded (CD8-positive T cells in stroma immediately adjacent/within tumor), and inflamed (CD8-positive T cells …

How Vocabulary Notebooks Change Student Knowledge Of Science Concepts And Vocabulary, Justin Wheeler

Department of Teaching, Learning, and Teacher Education: Theses and Other Student Research

This study was conducted to determine the effect that an explicit vocabulary strategy, the use of vocabulary notebooks, may have on students in an upper elementary science classroom. The study was conducted in a small mid-western town of approximately 14,000 people in an elementary school with approximately 415 students. The study was conducted in a science classroom of fifth-grade students in which the primary investigator was the teacher. The research question for this study was: How does student’s vocabulary knowledge of science concepts change when students create vocabulary notebook entries including definition, science concept, examples, and non-examples? Data sources collected …

Leaving Against Medical Advice From In-Patients Departments Rate, Reasons And Predicting Risk Factors For Re-Visiting Hospital Retrospective Cohort From A Tertiary Care Hospital, Obada Hasan, Muhammad Adil Samad, Hamza Khan, Maryam Sarfraz, Shahryar Noordin, Tashfeen Ahmad, Gul Nowshad

Section of Orthopaedic Surgery

Background: Approximately 1% to 2% of hospitalized patients get discharged or leave from the hospital against medical advice and up to 26% in some centers. They have higher readmission rate and risk of complications than patients who receive complete care. In this study we aimed to determine the rate of leave against medical advice (LAMA) and reasons for the same across different in-patient departments of a tertiary care hospital.
Methods: Retrospective cohort study on patients admitted in all departments at our institute over a 1-year period. All patients who were admitted to an in-patient ward at the hospital and who …

Effect Of Beaver On Brook Trout Habitat In North Shore, Lake Superior Streams, Kathryn Renik

Biology Graduate Theses

In Minnesota, North American Beavers Castor canadensis (hereafter Beaver) are considered to have an overall negative affect on native Brook Trout Salvelinus fontinalis. Brook Trout provide a valued and productive sport fishery to the North Shore streams of Lake Superior and since revival of the Beaver population from past trapping and timber harvest, a reexamination of the complex ecological relationship where the two taxa interact is imperative. Suitable Brook Trout habitat is characterized by cold, spring- fed water with silt-free rocky substrate and abundant cover, all of which Beaver may directly, or indirectly, affect. Data collection occurred on 79 (200 …

Material Intimacy: Bearing Witness, Listening, And Wandering The Ruins, Miriam R. Rowntree

English Dissertations - Archive

In this dissertation, I consider the rhetorical ecology of architectural ruins, specifically those of natural disaster, as actors in a system of human and nonhuman intra-action that has rhetorical potential for material intimacy. I argue that ruins address the human in ways that elicit a response. The human response enacts a paratactic praxis, which I explore in my first chapter as a practice that creates series or lists that call on the reader or the listener to fill the gaps between entities and make meaning out of the resulting juxtaposition of words, phrases, or collections. In the second, third, and …