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2019 Fall Faculty Conference: Reflecting On Our Values, Purpose & Principles, Academic Affairs

Fall Faculty Conference

The 2019 Fall Faculty Conference featured teaching showcases b Jennifer Bennett (Biology & Earth Science, Biochemistry & Molecular Biology Program), Dave Sheridan (Biology & Earth Science), Amy Sheeran (Modern Languages & Cultures), Allison McGrath (Education), and Melissa Gilbert (Center for Community Engagement). Breakout sessions were held by Kathryn Plank (Academic Affairs) with Margaret Koehler (English) and James Prysock (Social Justice & Activism), Terry Hermsen (English) with Melissa Gilbert (Center for Community Engagement), Shannon Lakanen (English) with Sam Boch (Nursing) and Anthony DeStefanis (History) and Simon Lawrence (Biology & Earth Science) and Bridget Newell (Philosophy) and Kathryn Plank (Center for Teaching …

Good Fishing And Good College, University Of Dayton

College of Arts and Sciences Newsroom

Roger J. Crum, professor of art history, was the faculty speaker Tuesday, Aug. 20, at the University of Dayton’s 2019 academic convocation, welcoming first-year students and new faculty. He has held the Graul Chair in Arts and Languages, directed numerous education abroad programs in Italy and received the College of Arts and Sciences’ Outstanding Teaching Award.

Wu Receives $1.7 Million Grant To Study Potential Prevention, Treatment For Non-Melanoma Skin Cancers, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

2019 Fall Faculty Conference: Reflecting On Our Values, Purpose, And Principles, Otterbein University

Staff Conferences

Program for the 2019 Fall Faculty Conference.

Impacts Of Hiv Cure Interventions On Viral Reservoirs In Tissues, Paul W. Denton, Ole S. Søgaard, Martin Tolstrup

Biology Faculty Publications

HIV reservoirs persist in infected individuals despite combination antiretroviral therapy and can be identified in secondary lymphoid tissues, in intestinal tissues, in the central nervous system as well as in blood. Clinical trials have begun to explore effects of small molecule interventions to perturb the latent viral infection, but only limited information is available regarding the impacts of HIV cure-related clinical interventions on viral reservoirs found in tissues. Of the 14 HIV cure-related clinical trials since 2012 that have evaluated the effects of small molecule interventions in vivo, four trials have examined the impacts of the interventions in peripheral …

Cytoplasmic Daxx Drives Sqstm1/P62 Phase Condensation To Activate Nrf2-Mediated Stress Response., Yi Yang, Thea L. Willis, Robert W. Button, Conor J. Strang, Yuhua Fu, Xue Wen, Portia R.C. Grayson, Tracey Evans, Rebecca J. Sipthorpe, Sheridan L. Roberts, Bing Hu, Jianke Zhang, Boxun Lu, Shouqing Luo

Department of Microbiology and Immunology Faculty Papers

Autophagy cargo recognition and clearance are essential for intracellular protein quality control. SQSTM1/p62 sequesters intracellular aberrant proteins and mediates cargo delivery for their selective autophagic degradation. The formation of p62 non-membrane-bound liquid compartments is critical for its function as a cargo receptor. The regulation of p62 phase separation/condensation has yet been poorly characterised. Using an unbiased yeast two-hybrid screening and complementary approaches, we found that DAXX physically interacts with p62. Cytoplasmic DAXX promotes p62 puncta formation. We further elucidate that DAXX drives p62 liquid phase condensation by inducing p62 oligomerisation. This effect promotes p62 recruitment of Keap1 and subsequent Nrf2-mediated …

Bozick, Frank J., Collection, 1927-2008, Special Collections, Leonard H. Axe Library

Finding Aids

Frank J. Bozick was born February 11, 1903 in Frontenac, Kansas. Frank was one of six children born to Frank and Teresa (Yartz) Bozick. At age 38, and at the beginning of the United States’ involvement in World War II, Frank volunteered for the US Army. He joined an Ordnance Battalion mostly made up Kansas volunteers. After the war, Frank return to Frontenac, Kansas. He was a member of the Sacred Heart Catholic Church and the Frontenac American Legion. He was an avid fisherman, and outdoorsman, and traveled to locations such as Alaska, and to Slovenia and Croatia, to visit …

Evolutionary History Predicts High‐Impact Invasions By Herbivorous Insects, Angela M. Mech, Kathryn A. Thomas, Travis D. Marsico, Daniel A. Herms, Craig R. Allen, Matthew P. Ayres, Kamal J.K. Gandhi, Jessica Gurevitch, Nathan P. Havill, Ruth A. Hufbauer, Andrew M. Liebhold, Kenneth F. Raffa, Ashley N. Schulz, Daniel R. Uden, Patrick C. Tobin

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

1. A long‐standing goal of invasion biology is to identify factors driving highly variable impacts of non‐native species. Although hypotheses exist that emphasize the role of evolutionary history (e.g., enemy release hypothesis & defense‐free space hypothesis), predicting the impact of non‐native herbivorous insects has eluded scientists for over a century.

2. Using a census of all 58 non‐native conifer‐specialist insects in North America, we quantified the contribution of over 25 factors that could affect the impact they have on their novel hosts, including insect traits (fecundity, voltinism, native range, etc.), host traits (shade tolerance, growth rate, wood density, etc.), and …

Acquisitions Unit Annual Report 2018-2019, Andrée J. Rathemacher

Technical Services Reports and Statistics

Annual Report of the Acquisitions Unit, University Libraries, University of Rhode Island for FY2019. Covers personnel, work flow, special projects, and serial, monograph, and e-resource acquisitions. Supplemental files include data on library materials expenditures by a number of variables as well as important working documents from the year.

Workplace Incivility Against Women In Stem: Insights And Best Practices, Mahima Saxena, Timothy Adam Geiselman, Sheng Zhang

Psychology Faculty Publications

As demonstrated by both empirical and non-empirical research, women are more likely than men to be a target of workplace incivility. This manifests in a variety of negative outcomes for female employees, including turnover intentions, poor performance, and higher levels of stress. The problem is exacerbated for women in STEM fields due to factors unique to these industries. Herein, we outline the unique characteristics of STEM organizations that can foster the creation and sustenance of an atmosphere promoting workplace incivility against female employees. Then, we provide five best practice recommendations geared toward reducing incivility, improving work climate, and promoting overall …

Occurrence Of Aflatoxin And Zearalenone In Concentrate Feeds And Milk Contamination With Aflatoxin M1 And Bacterial Pathogens In Malawi, Chunala Alexico Njombwa

LSU Doctoral Dissertations

Multiple studies were conducted in Malawi to: 1) evaluate knowledge and perception of dairy farmers towards molds, mycotoxins and associated adverse effects; 2) evaluate dairy farmers’ knowledge and perception on milk contamination, proper milk handling practices and adverse health effects associated with raw milk consumption; 3) determine levels of aflatoxins and zearalenone (ZEN) in concentrate feedstuffs; 4) assess prevalence and levels of aflatoxin M₁(AFM₁) in raw milk, dietary exposure and estimate HCC risks to children and adults; 5) assess Salmonella and E. colicontamination in raw and processed milk from selected small scale farms and major …

More Than Just A Place To Exercise, Justin Whitmore

University of Mississippi News

South Campus Recreation Center aims to benefit all aspects of student well-being

Conservation Genomic Analysis Reveals Ancient Introgression And Declining Levels Of Genetic Diversity In Madagascar’S Hibernating Dwarf Lemurs, Rachel C. Williams, Marina B. Blanco, Jelmer W. Poelstra, Kelsie E. Hunnicutt, Aaron A. Comeault, Anne D. Yoder

Biological Sciences: Faculty Scholarship

Madagascar’s biodiversity is notoriously threatened by deforestation and climate change. Many of these organisms are rare, cryptic, and severely threatened, making population-level sampling unrealistic. Such is the case with Madagascar’s dwarf lemurs (genus Cheirogaleus), the only obligate hibernating primate. We here apply comparative genomic approaches to generate the first genome-wide estimates of genetic diversity within dwarf lemurs. We generate a reference genome for the fat-tailed dwarf lemur, Cheirogaleus medius, and use this resource to facilitate analyses of high-coverage (~30×) genome sequences for wild-caught individuals representing species: C. sp. cf. medius, C. major, C. crossleyi, and C. sibreei. This study represents …

A Panel Of Protein Kinase Chemosensors Distinguishes Different Types Of Fatty Liver Disease, Jon R. Beck, Fatima Cabral, Karuna Rasineni, Carol A. Casey, Edward N. Harris, Cliff I. Stains

Department of Chemistry: Faculty Publications

The worldwide incidence of fatty liver disease continues to rise, which may account for concurrent increases in the frequencies of more aggressive liver ailments. Given the existence of histologically identical fatty liver disease subtypes, there is a critical need for the identification of methods that can classify disease and potentially predict progression. Herein, we show that a panel of protein kinase chemosensors can distinguish fatty liver disease subtypes. These direct activity measurements highlight distinct differences between histologically identical fatty liver diseases arising from diets rich in fat versus alcohol and identify a previously unreported decrease in p38α activity associated with …

Global Sinusoidal Seasonality In Precipitation Isotopes, Scott T. Allen, Scott Jasechko, Wouter R. Berghuijs, Jeffrey M. Welker, Gregory R. Goldsmith, James W. Kirchner

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Quantifying seasonal variations in precipitation δ²H and δ¹⁸O is important for many stable isotope applications, including inferring plant water sources and streamflow ages. Our objective is to develop a data product that concisely quantifies the seasonality of stable isotope ratios in precipitation. We fit sine curves defined by amplitude, phase, and offset parameters to quantify annual precipitation isotope cycles at 653 meteorological stations on all seven continents. At most of these stations, including in tropical and subtropical regions, sine curves can represent the seasonal cycles in precipitation isotopes. Additionally, the amplitude, phase, and offset parameters of …

Identifying Phytochemicals From Biomedical Literature Utilizing Semantic Knowledge Sources, Indra Neil Sarkar, Wayne Law, Michael J. Balick

Faculty and Staff Publications & Presentations

Chemicals derived from plants (phytochemicals) are major concepts of interest in the study of medicinal plants. To date, efforts to catalogue and organize phytochemical knowledge have resorted to manual approaches. This study explored the potential to leverage publicly accessible semantic knowledge sources for identifying possible phytochemicals. Within the context of this feasibility study, putative phytochemicals were identified for more than 4,000 plants from the Medical Subject Headings Supplementary Concept Records and the Semantic MEDLINE Database. An examination of phytochemicals identified for five selected plant species using the method developed here reveals that there is a disparity in electronically catalogued phytochemical …

Human Rights, Emotion, And Critical Realism: Proposing An Emotional Ontology Of International Human Rights, Ben Luongo

USF Tampa Graduate Theses and Dissertations

This dissertation proposes a critical realist framework of human rights and argues that emotion plays a foundational role in constituting a human rights ontology. I build this framework as a critical response to other IR human rights theories which have largely been developed in accordance with either empiricist or rationalist paradigms. Both empiricist and rationalist theories fail to articulate a firm ontological foundation which can support their human rights claims.

This ontological concern may not seem too important for human rights scholars interested in more substantive political issues, but it does lead to problems because no human rights theory is …

Cytoplasmic Daxx Drives Sqstm1/P62 Phase Condensation To Activate Nrf2-Mediated Stress Response, Yi Yang, Thea L. Willis, Robert W. Button, Conor J. Strang, Yuhua Fu, Xue Wen, Portia R.C. Grayson, Tracey Evans, Rebecca J. Sipthorpe, Sheridan L. Roberts, Bing Hu, Jianke Zhang, Boxun Lu, Shouqing Luo

Peninsula Dental School

No abstract provided.

Human Auditory Discrimination Of Bottlenose Dolphin Signature Whistles Masked By Noise: Investigating Perceptual Strategies For Anthropogenic Noise Pollution, Evan L. Morrison

Theses

Anthropogenic masking noise in the world’s oceans is known to impede many species’ ability to perceive acoustic signals, but little research has addressed how this noise pollution affects the detection of bioacoustic signals used for communication. Bottlenose dolphins (Tursiops truncatus) use signature whistles which contain identification information. Past studies have shown that human participants can be used as models for dolphin hearing, but most previous research investigated echolocation. In Experiment 1, human participants were tested on their ability to auditorily discriminate among signature whistles from three dolphins. Participants’ performance was nearly errorless (M = 98.8%). In Experiment 2, participants identified …

Are Microclimate Conditions In El Malpais National Monument Caves In New Mexico, Usa Suitable For Pseudogymnoascus Growth?, Terry J. Torres-Cruz, Andrea Porras-Alfaro, Nicole A. Caimi, Ogochukwu Nwabologu, Edward W. Strach, Kaitlyn J.H. Read, Jesse M. Young, Debbie C. Buecher, Diana E. Northup

International Journal of Speleology

White-nose syndrome (WNS) is a bat disease caused by the fungal pathogen Pseudogymnoascus destructans, which thrives in cold and very humid environments where bats frequently hibernate. Conidia of Pseudogymnoascus species are often documented on bats prior to the onset of WNS, but characterization of high-risk areas defined by microclimate cave conditions have been lacking. Investigating the occurrence of this fungal genus and appropriate environmental conditions to support P. destructans in southwestern U.S. caves is key to understanding the sites most likely to be impacted by WNS. Microclimate conditions in ten caves at El Malpais (ELMA) National Monument in New …

Using Machine Learning For Antimicrobial Resistant Dna Identification, Jason I. Lingle, John Santerre

SMU Data Science Review

In this paper, we present a novel machine learning-based methodology for identifying bacteria DNA sub-sequences that are associated with antimicrobial resistance. The dramatic rise in cases of antibiotic resistant bacteria has been an increasing threat across the globe as the existing treatments are rendered ineffective in treating most of these cases due to mutations of their DNA. Among the most recent bacteria to display antimicrobial resistance (AMR) is Neisseria Gonorrhea with the first global treatment failure taking place in 2016. In 2018, new cases of resistance to multiple, high levels of antibiotics were reported in the United Kingdom and Australia. …

Teacher Retention: Identifying Areas To Improve Teacher Recruitment And Retention In North Carolina Public Schools, Bin Yu, Nuoya Rezsonya, Jacob Drew

SMU Data Science Review

In this paper, we established a regression model to identify factors that significantly influenced both positively and negatively school-level yearly teacher attrition rate within North Carolina public schools using Belk Endowment Educational Attainment Data Repository for North Carolina Public Schools, district-level North Carolina IRS income tax data [2], and county-level North Carolina crime data[3]. Frequent teacher turnover has been negatively affecting teacher retention, student academic achievement, and educational attainment. School administrators are struggling to reduce teacher attrition rate since teacher retention is important to students academic achievements. Our regression model utilized an eXtreme Gradient Boosting(XGBoost) Regression model to predict school-level …

Full Stem Ahead, Shawn Knowlton, Megan Elbel

Honors Program: Expanded Learning Clubs

After school club that introduces students to STEM and builds problem-solving skills through hands-on, interactive activities.

Phylogenetic Trees And Networks Can Serve As Powerful And Complementary Approaches For Analysis Of Genomic Data, Christopher Blair, Cécile Ané

Publications and Research

Genomic data have had a profound impact on nearly every biological discipline. In systematics and phylogenetics, the thousands of loci that are now being sequenced can be analyzed under the multispecies coalescent model (MSC) to explicitly account for gene tree discordance due to incomplete lineage sorting (ILS). However, the MSC assumes no gene flow post divergence, calling for additional methods that can accommodate this limitation. Explicit phylogenetic network methods have emerged, which can simultaneously account for ILS and gene flow by representing evolutionary history as a directed acyclic graph. In this point-of-view we highlight some of the strengths and limitations …

Genetically-Encoded Sensors To Detect Fatty Acid Production And Trafficking, Emilio P. Mottillo

Hypertension and Vascular Research Articles

Objective: Fatty acids are important for biological function; however, in excess, they can cause metabolic dysregulation. Methods to image and detect fatty acids in real time are lacking. Therefore, the current study examined the dynamics of fatty acid trafficking and signaling utilizing novel fluorescent and luminescent approaches.

Methods: We generated fluorescent and luminescent-based genetically-encoded sensors based upon the ligand-dependent interaction between PPARα and SRC-1 to image and detect cellular dynamics of fatty acid trafficking.

Results: The use of a fluorescent sensor demonstrates that fatty acids traffic rapidly from lipid droplets to the nucleus. Both major lipases ATGL and HSL contribute …

Incorporating Climate Change In The Classroom Provides Hope For The Future Of Our Planet, Alicia Rohan

Browse All News

No abstract provided.

Alteration Of Tobacco Alkaloid Content Through Modification Of Specific Cytochrome P450 Genes, Ralph E. Dewey, Balazs Siminszky, Steven W. Bowen, Lily Gavilano

Plant and Soil Sciences Faculty Patents

Compositions and methods for reducing the level of nornicotine and N'-nitrosonomicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for cytochrome P450s that are involved in the metabolic conversion of nicotine to nornicotine in these plants. Expression cassettes, vectors, plants, and plant parts thereof comprising inhibitory sequences that target expression or function of the disclosed cytochrome P450 polypeptides are also provided. Methods for the use of these novel sequences to inhibit expression or function of cytochrome P450 polypeptides involved in this metabolic conversion are also provided. The methods find use in …

Thylakoid Localized Bestrophin-Like Proteins Are Essential For The Co2 Concentrating Mechanism Of Chlamydomonas Reinhardtii, Ananya Mukherjee, Chun Sing Lau, Charlotte E. Walker, Ashwani K. Rai, Camille I. Prejean, Gary Yates, Thomas Emrich-Mills, Spencer G. Lemoine, David J. Vinyard, Luke C.M. Mackinder, James V. Moroney

Faculty Publications

© 2019 National Academy of Sciences. All rights reserved. The green alga Chlamydomonas reinhardtii possesses a CO2 concentrating mechanism (CCM) that helps in successful acclimation to low CO2 conditions. Current models of the CCM postulate that a series of ion transporters bring HCO3− from outside the cell to the thylakoid lumen, where the carbonic anhydrase 3 (CAH3) dehydrates accumulated HCO3− to CO2, raising the CO2 concentration for Ribulose bisphosphate carboxylase/oxygenase (Rubisco). Previously, HCO3− transporters have been identified at both the plasma membrane and the chloroplast envelope, but the transporter thought to be on the thylakoid membrane has not been identified. …

Seasonal Variability Of Forces Controlling Sedimentation In The Sundarbans National Forest, Bangladesh, Carol A. Wilson, E. J. Bomer

Faculty Publications

Southwest Bangladesh, located on the Ganges-Brahmaputra-Meghna delta, is experiencing the impacts of sea level rise (SLR) due to processes at both the local and global scale. In particular, regional alterations of the hydrodynamic network, due to embankment construction, have drastically altered effective SLR, placing millions of inhabitants at risk of prolonged inundation, and threatening the world's largest continuous mangrove stand, the Sundarbans National Forest (SNF). In order to effectively employ landscape recovery solutions, an understanding of local sediment transport and deposition is critical. This field-based study investigates the sediment dynamics between the mangrove platform and tidal channels of the SNF …

Hidden Bias In The Dud-E Dataset Leads To Misleading Performance Of Deep Learning In Structure-Based Virtual Screening, Lieyang Chen, Anthony Cruz, Steven Ramsey, Callum J. Dickson, Jose S. Duca, Viktor Hornak, David R. Koes, Tom Kurtzman

Publications and Research

Recently much effort has been invested in using convolutional neural network (CNN) models trained on 3D structural images of protein-ligand complexes to distinguish binding from non-binding ligands for virtual screening. However, the dearth of reliable protein-ligand x-ray structures and binding affinity data has required the use of constructed datasets for the training and evaluation of CNN molecular recognition models. Here, we outline various sources of bias in one such widely-used dataset, the Directory of Useful Decoys: Enhanced (DUDE). We have constructed and performed tests to investigate whether CNN models developed using DUD-E are properly learning the underlying physics of molecular …