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Synthesis Of Betulinic Acid Via Baylis-Hillman Reaction, Sai Krishna Kommineni

Theses and Dissertations

Betulin is readily isolated from the bark of birch trees using simple extraction techniques and this molecule as well as its derivatives (eg. betulinic acid) exhibit impressive levels of biological activity. While it is naturally available and shows selective toxicity towards certain cancers, betulin suffers from a general lack of solubility in aqueous conditions. In this regard, we took up a project involving the synthesis of conjugates of betulin with improved solubility characteristics and we were able to identify a series of compounds that showed cytotoxicity against breast and pancreatic cancer cells.

This thesis describes our efforts on the development …

Usft Prog Proposal Cas Integrative Bio Marine Biology Bs 20190822, Usf Libraries

All Assessment Data

No abstract provided.

08-22-2019 New Swosu Faculty Prepare For School Year, Southwestern Oklahoma State University

THE BARK ARCHIVE 2019

Southwestern Oklahoma State University’s new faculty recently met to prepare for the 2019-20 school year.

Diagnosis In 2.127 Seconds: Solving A Years-Long Vomiting Mystery Using Ai, Research And Brain Power, Staff

Browse All News

No abstract provided.

Cancer Doesn't Care About Equality, So Uab Gets More Scholars To Care About Cancer, Matt Windsor

Browse All News

No abstract provided.

Histone H4 H75e Mutation Attenuates Global Genomic And Rad26-Independent Transcription-Coupled Nucleotide Excision Repair, Shisheng Li, Kathiresan Selvam, Sheikh Arafatur Rahman

Faculty Publications

Nucleotide excision repair (NER) consists of global genomic NER (GG-NER) and transcription coupled NER (TC-NER) subpathways. In eukaryotic cells, genomic DNA is wrapped around histone octamers (an H3-H4 tetramer and two H2A-H2B dimers) to form nucleosomes, which are well known to profoundly inhibit the access of NER proteins. Through unbiased screening of histone H4 residues in the nucleosomal LRS (loss of ribosomal DNA-silencing) domain, we identified 24 mutations that enhance or decrease UV sensitivity of Saccharomyces cerevisiae cells. The histone H4 H75E mutation, which is largely embedded in the nucleosome and interacts with histone H2B, significantly attenuates GG-NER and Rad26-independent …

Ideology And Risk Focus: A Preliminary Exploration Of The Effect Of Judicial Ideology On Risk Focus In Supreme Court Opinion Construction, Gordon Ballingrud, Caitlein Jammo

Denver Law Review

No abstract provided.

Chanticleer | Vol 85, Issue 13, Jacksonville State University

Chanticleer

No abstract provided.

Daily Eastern News: August 22,2019, Eastern Illinois University

August

No abstract provided.

Space Telescope And Optical Reverberation Mapping Project. Viii. Time Variability Of Emission And Absorption In Ngc 5548 Based On Modeling The Ultraviolet Spectrum, Gerard A. Kriss, Gisella De Rosa, Justin Ely, Bradley M. Peterson, J. Kaastra, M. Mehdipour, Gary J. Ferland, Maryamossadat Dehghanian, S. Mathur, Rick Edelson, Kirk T. Korista, N. Arav, Aaron J. Barth, Misty C. Bentz, W. Niel Brandt, D. Michael Crenshaw, E. Dalla Bonta, K. D. Kenney, C. Done, Michael Eracleous, Michael M. Fausnaugh, E. Gardner, Michael R. Goad, Catherine J. Grier, Keith Horne, Christopher S. Kochanek, I. M. Mchardy, Hagai Netzer, Anna Pancoast, L. Pei, Richard W. Pogge, Daniel Proga

Physics & Astronomy Faculty Research

We model the ultraviolet spectra of the Seyfert 1 galaxy NGC 5548 obtained with the Hubble Space Telescope during the 6 month reverberation mapping campaign in 2014. Our model of the emission from NGC 5548 corrects for overlying absorption and deblends the individual emission lines. Using the modeled spectra, we measure the response to continuum variations for the deblended and absorption-corrected individual broad emission lines, the velocity-dependent profiles of Lyα and C iv, and the narrow and broad intrinsic absorption features. We find that the time lags for the corrected emission lines are comparable to those for the original data. …

Learnfca: A Fuzzy Fca And Probability Based Approach For Learning And Classification, Suraj Ketan Samal

School of Computing: Dissertations, Theses, and Student Research

Formal concept analysis(FCA) is a mathematical theory based on lattice and order theory used for data analysis and knowledge representation. Over the past several years, many of its extensions have been proposed and applied in several domains including data mining, machine learning, knowledge management, semantic web, software development, chemistry ,biology, medicine, data analytics, biology and ontology engineering.

This thesis reviews the state-of-the-art of theory of Formal Concept Analysis(FCA) and its various extensions that have been developed and well-studied in the past several years. We discuss their historical roots, reproduce the original definitions and derivations with illustrative examples. Further, we provide …

Precision Nomenclature For The New Genomics, Harris A. Lewin, Jennifer A. Marshall Graves, Oliver A. Ryder, Alexander S. Graphodatsky, Stephen James O'Brien

Biology Faculty Articles

The confluence of two scientific disciplines may lead to nomenclature conflicts that require new terms while respecting historical definitions. This is the situation with the current state of cytology and genomics, which offer examples of distinct nomenclature and vocabularies that require reconciliation. In this article, we propose the new terms C-scaffold (for chromosome-scale assemblies of sequenced DNA fragments, commonly named scaffolds) and scaffotype (the resulting collection of C-scaffolds that represent an organism's genome). This nomenclature avoids conflict with the historical definitions of the terms chromosome (a microscopic body made of DNA and protein) and karyotype (the collection of images …

Avian Binocularity And Adaptation To Nocturnal Environments: Genomic Insights Froma Highly Derived Visual Phenotype, Rui Borges, Joao Fonseca, Cidalia Gomes, Warren E. Johnson, Stephen James O'Brien, Guojie Zhang, M. Thomas P. Gilbert, Erich D. Jarvis, Agostinho Antunes

Biology Faculty Articles

Typical avian eyes are phenotypically engineered for photopic vision (daylight). In contrast, the highly derived eyes of the barn owl (Tyto alba) are adapted for scotopic vision (dim light). The dramatic modifications distinguishing barn owl eyes from other birds include: 1) shifts in frontal orientation to improve binocularity, 2) rod-dominated retina, and 3) enlarged corneas and lenses. Some of these features parallel mammalian eye patterns, which are hypothesized to have initially evolved in nocturnal environments. Here, we used an integrative approach combining phylogenomics and functional phenotypes of 211 eye-development genes across 48 avian genomes representing most avian orders, …

Inevitable Future: Space Colonization Beyond Earth With Microbes First, Jose Lopez, Raquel S. Peixoto, Alexandre S. Rosado

Biology Faculty Articles

Based on modern microbiology, we propose a major revision in current space exploration philosophy and planetary protection policy, especially regarding microorganisms in space. Mainly, microbial introduction should not be considered accidental but inevitable. We hypothesize the near impossibility of exploring new planets without carrying and/or delivering any microbial travelers. In addition, although we highlight the importance of controlling and tracking such contaminations—to explore the existence of extraterrestrial microorganisms—we also believe that we must discuss the role of microbes as primary colonists and assets, rather than serendipitous accidents, for future plans of extraterrestrial colonization. This paradigm shift stems partly from the …

Anti-Pd-1 Monoclonal Antibody Medi0680 In A Phase I Study Of Patients With Advanced Solid Malignancies., Aung Naing, Jeffrey Infante, Sanjay Goel, Howard Burris, Chelsea Black, Shannon Marshall, Ikbel Achour, Susannah Barbee, Rena May, Chris Morehouse, Kristen Pollizzi, Xuyang Song, Keith Steele, Nairouz Elgeioushi, Farzana Walcott, Joyson Karakunnel, Patricia Lorusso, Amy Weise, Joseph Eder, Brendan Curti, Michael Oberst

Articles, Abstracts, and Reports

BACKGROUND: The safety, efficacy, pharmacokinetics, and pharmacodynamics of the anti-programmed cell death-1 antibody MEDI0680 were evaluated in a phase I, multicenter, dose-escalation study in advanced solid malignancies.

METHODS: MEDI0680 was administered intravenously once every 2 weeks (Q2W) or once every 3 weeks at 0.1, 0.5, 2.5, 10 or 20 mg/kg. Two cohorts received 20 mg/kg once a week for 2 or 4 weeks, then 20 mg/kg Q2W. All were treated for 12 months or until progression. The primary endpoint was safety. Secondary endpoints were efficacy and pharmacokinetics. Exploratory endpoints included pharmacodynamics.

RESULTS: Fifty-eight patients were treated. Median age was 62.5 …

The Establishment Risk Of Lycorma Delicatula (Hemiptera: Fulgoridae) In The United States And Globally, Tewodros T. Wakie, Lisa G. Neven, Wee L. Yee, Zhaozhi Lu

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Native to Asia, the spotted lanternfly, Lycorma delicatula (White), is an emerging pest of many commercially important plants in Korea, Japan, and the United States. Determining its potential distribution is important for proactive measures to protect commercially important commodities. The objective of this study was to assess the establishment risk of L. delicatula globally and in the United States using the ecological niche model MAXENT, with a focus on Washington State (WA), where large fruit industries exist. The MAXENT model predicted highly suitable areas for L. delicatula in Asia, Oceania, South America, North America, Africa, and Europe, but also predicted …

The New Hampshire, Vol. 109 [110], No. 01 (Aug. 22, 2019), The New Hampshire

The New Hampshire Print Edition

An independent student produced newspaper from the University of New Hampshire. This volume was printed as 109, but it is the 110th volume in the series.

Secrecy Capacity And Secure Distance For Diffusion-Based Molecular Communication Systems, Lorenzo Mucchi, Alessio Martinelli, Sara Jayousi, Stefano Caputo, Massimiliano Pierobon

School of Computing: Faculty Publications

The biocompatibility and nanoscale features of Molecular Communication (MC) make this paradigm, based on molecules and chemical reactions, an enabler for communication theory applications in the healthcare at its biological level (e.g., bimolecular disease detection/monitoring and intelligent drug delivery). However, the adoption of MC-based innovative solutions into privacy and security-sensitive areas is opening new challenges for this research field. Despite fundamentals of information theory applied to MC have been established in the last decade, research work on security in MC systems is still limited. In contrast to previous literature focused on challenges, and potential roadmaps to secure MC, this paper …

Mice Exposed To Combined Chronic Low-Dose Irradiation And Modeled Microgravity Develop Long-Term Neurological Sequelae, Amber M. Paul, Eliah G. Overbey, William A. Da Silveira, Candice G.T. Tahimic, Sigrid S. Reinsch, Nathaniel Szewczyk, Seta Stanbouly, Charles Wang, Jonathan M. Galazka, Xiao Wen Mao

Publications

Spaceflight poses many challenges for humans. Ground-based analogs typically focus on single parameters of spaceflight and their associated acute effects. This study assesses the long-term transcriptional effects following single and combination spaceflight analog conditions using the mouse model: simulated microgravity via hindlimb unloading (HLU) and/or low-dose γ-ray irradiation (LDR) for 21 days, followed by 4 months of readaptation. Changes in gene expression and epigenetic modifications in brain samples during readaptation were analyzed by whole transcriptome shotgun sequencing (RNA-seq) and reduced representation bisulfite sequencing (RRBS). The results showed minimal gene expression and cytosine methylation alterations at 4 months readaptation within single …

Attitudes Of Nurses Toward Children With Disabilities, Kathleen A. Marsala-Cervasio

Dissertations

The attitudes of U.S. nurses toward children with disabilities have not been adequately measured over time and after an educational intervention. Disability content has not been a priority in nursing education and, if present, the focus has been on adults with disabilities. The attitudes of nurses play a significant role in the provision of quality healthcare services they provide for children with disabilities. This quantitative, experimental research measured the attitudes of graduating nursing students (N= 88) toward children with disabilities utilizing the Attitudes Towards Disabled Persons Scale (ATDP-B) before and after disability education.

Attitudes, Subjective Norms, And Perceived Behavioral Control: Critical Care Nurses' Intentions To Provide Culturally Congruent Care To Arab Muslims, Stephen R. Marrone

Dissertations

The purpose of this study was to investigate the relationships among critical care nurses' attitudes, subjective norms, perceived behavioral control, and intentions to provide culturally congruent care to Arab Muslims. A purposive convenience sample of 208 critical care nurses participated in this investigation. Data were collected using four Likert-scale instruments. Each subject received an attitude score, subjective norms score, perceived behavioral control score, and intention score.

Design And Implementation Of Degenerate Qpcr/Qrt-Pcr Primers To Detect Microbial Nitrogen Metabolism In Wastewater And Wastewater-Related Samples, Ryan F. Keeley

USF Tampa Graduate Theses and Dissertations

Nitrogen cycling processes can be tracked using quantitative Polymerase Chain Reaction (qPCR) to determine the presence and qReverse Transcriptase-PCR (qRT-PCR) to determine expression of key genes, or ‘biological markers’, for nitrogen metabolism. Nitrification is catalyzed in part, by two enzymes: ammonia monooxygenase (AMO; NH3 NH2OH) and nitrite oxidoreductase (NXR; NO2- NO3-). For denitrification, four enzymes act sequentially: nitrate reductase (NAR/NAP; NO3- NO2-), nitrite reductase (NIR; NO2- NO), nitric oxide reductase (NOR; NO  N2O), and nitrous oxide reductase (NOS; N2O  N2). A principle of wastewater treatment (WWT) is to remove excess nitrogen by taking advantage of natural nitrogen cycling …

The Gene Silencing Protein Morc-1 Topologically Entraps Dna And Forms Multimeric Assemblies To Cause Dna Compaction., Hyeongjun Kim, Linda Yen, Somsakul P. Wongpalee, Jessica A. Kirshner, Nicita Mehta, Yan Xue, Jonathan B. Johnston, Alma L. Burlingame, John K. Kim, Joseph J. Loparo, Steve E. Jacobsen

Physics & Astronomy Faculty Publications

Highlights

• Caenorhabditis elegans MORC-1 traps DNA loops

• Recruitment of additional MORC-1s cause further loop trapping and DNA compaction

• MORC-1 assemblages become topologically entrapped on DNA

• MORC-1 forms discrete foci in vivo and can phase transition in vitro

Summary

Microrchidia (MORC) ATPases are critical for gene silencing and chromatin compaction in multiple eukaryotic systems, but the mechanisms by which MORC proteins act are poorly understood. Here, we apply a series of biochemical, single-molecule, and cell-based imaging approaches to better understand the function of the Caenorhabditis elegans MORC-1 protein. We find that MORC-1 binds to DNA in a length-dependent but sequence non-specific …

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Georgia Southern launches new online IT degree
• Georgia Southern graduate student conducts research as snake specialist in Honduras
• Georgia Southern school psychology students work with special needs children in Ecuador, experience is life-changing
• Georgia Southern's annual economic impact continues to grow, topping more than $1 billion

Shame And Guilt Mediate The Relationship Between Adult Attachment Style And Ptsd Severity Among Combat Veterans, Sam John Leonard

Electronic Theses and Dissertations Archive

Posttraumatic Stress Disorder (PTSD) is associated with the expression of various social emotions, including shame and guilt. Although relations between shame, guilt, and PTSD have been researched extensively in terms of clinical relevance, the mechanisms underlying the relationships are still generally unknown. Adult attachment style is a social bonding mechanism that is related to both social emotions and PTSD severity. The present study investigates relations among adult attachment style, PTSD severity, shame, and guilt in a sample of 208 US military veterans and active duty personnel who served in combat zones. The study tested a mediational model, such that shame …

Generation Of An Oncolytic Adenovirus Targeting The Cxcr4 And Cxcr7 Chemokine Receptors In Breast Cancer, Samia Melissa O'Bryan

LSU Doctoral Dissertations

Breast cancer is the most diagnosed cancer in women under 60 and the second most diagnosed cancer in women over 60. While treatments for localized breast cancer are quite successful with high survival rates at 99%, advanced breast cancer remains hard to treat with a nearly 75% decrease in survival. Current treatments are inefficient at treating advanced stages of breast cancer, and thus, new therapies are sorely needed to address the complexity of advanced stage breast cancer. The ideal therapy would be capable of systemic administration, targets cancer cells and spares normal tissue. Oncolytic adenovirus is an ideal therapeutic vector …

Artificial Intelligence Based Wrist Fracture Classification, Dineep Thomas

LSU Master's Theses

The problem of predicting wrist fractures from X-rays using Artificial Intelligence (AI) methods is addressed. Wrist fractures are the most commonly misdiagnosed fractures because of the complex anatomical structure of the wrist bone which includes several different bones. This research provides a predictive solution to automate the process of wrist fracture classifications and outlines a visualization technique to identify the probable location of the fractured region on the X-rays. This thesis describes a deep learning based approach for wrist fracture classification. Deep convolutional neural network (CNN) based models have been used for wrist fracture classification by combining different optimization techniques. …

Media Literacy Education For All Ages, Päivi Rasi, Hanna Vuojärvi, Heli Ruokamo

Journal of Media Literacy Education

This special issue of the Journal of Media Literacy Education explores the role of media literacy across the lifespan. Media literacy education interventions must be designed to meet the needs of individuals of different ages by understanding the life roles and goals that they have across the lifespan. Different pedagogical strategies are required to effectively address the media literacy competencies of young children, teens, adults, parents, and older adults. In old age, media literacy education may support cognitive functioning and social relationships and help people critically assess health-related information and services. Adopting a life course perspective enables the examination of …

Predicting Premature Birth Risk With Cfrna, Jason Lin, Jonathan Marin, John Santerre

SMU Data Science Review

Identifying which genes are early indicators for preterm births using cell-free ribonucleic acid (cfRNA) from non-invasive blood tests provided by pregnant women can improve prenatal care. Currently, there are no medical tests for early detection of preterm birth risk in routine checkups for pregnant women. Recent studies have shown potential genes that can predict preterm birth. Machine learning techniques are utilized to see if the Area Under the Curve (AUC) can be improved upon when evaluating the prediction accuracy for chosen genes sequences and concentrations. Using cell-free RNA data from non-invasive blood tests in conjunction with machine learning, we improve …

Nature And Nurture: How Our Genes And Environments Shape Our Lives Bio 440g, Michael Cerbo

Library Impact Statements

No abstract provided.