Digital Commons Network^™

Validation Of A Host Response Test To Distinguish Bacterial And Viral Respiratory Infection., Emily C. Lydon, Ricardo Henao, Thomas W. Burke, Mert Aydin, Bradly P. Nicholson, Seth W. Glickman, Vance G. Fowler, Eugenia B. Quackenbush, Charles Cairns, Stephen F. Kingsmore, Anja K. Jaehne, Emanuel P. Rivers, Raymond J. Langley, Elizabeth Petzold, Emily R. Ko, Micah T. Mcclain, Geoffrey S. Ginsburg, Christopher W. Woods, Ephraim L. Tsalik

Emergency Medicine Articles

BACKGROUND: Distinguishing bacterial and viral respiratory infections is challenging. Novel diagnostics based on differential host gene expression patterns are promising but have not been translated to a clinical platform nor extensively tested. Here, we validate a microarray-derived host response signature and explore performance in microbiology-negative and coinfection cases.

METHODS: Subjects with acute respiratory illness were enrolled in participating emergency departments. Reference standard was an adjudicated diagnosis of bacterial infection, viral infection, both, or neither. An 87-transcript signature for distinguishing bacterial, viral, and noninfectious illness was measured from peripheral blood using RT-PCR. Performance characteristics were evaluated in subjects with confirmed bacterial, …

Amendments To The 1995 Offshore Constitutional Settlement, Department Of Fisheries

Fisheries Management Papers

No abstract provided.

The Periodical Fall 2019, Southern Adventist University

the Periodical – Chemistry Department Newsletter

Volume 7, issue 1 of the Periodical includes articles about new faculty member Tamie Suzuki, an alumni spotlight, general department news, at a pictorial listing of 2019 December chemistry graduates.

Faculty Notes, John Carroll University

Faculty Notes - John Carroll University

Fall 2019, Volume 12, Issue 2

Physical And Biological Consequences Of Giant Kelp (Macrocystis Pyrifera) Removals Within A Central California Kelp Forest, Steven Ryan Cunningham

SNS Master's Theses

The giant kelp (Macrocystis pyrifera) is a well-studied foundation species that builds complex biogenic habitat and contributes fixed carbon to the base of food webs. Kelp forest systems are some of the most productive ecosystems in the world and can sustain high levels of species richness and abundance. It has long been debated whether these systems are rich due to the (1) complex habitat structure of the giant kelp or (2) the kelp's high growth rates that provide an abundance of food for primary consumers. Giant kelp modifies its environment by creating shade with its surface canopy, slowing …

Green Club After School Program Curriculum, Megan Willburn

Honors Program: Expanded Learning Clubs

Green Club is an after school program which encourages students to develop environmental empathy, passions for environmental sustainability, and knowledge about the workings of environmental systems.

Impact Of Remembering Vs. Knowing On Strength Of Belief In Neuromyths, Kailee Jackola

Mahurin Honors College Capstone Experience/Thesis Projects

As technology advances, misinformation can be spread easier than ever before. Many things the general public believe to be true are either completely false or contradict research findings. However, many people are not willing to give up their belief in false information, even if there is evidence to refute it. Neuromyths are a particular type of widespread misinformation involving incorrect beliefs about brain function (e.g., people can be either left-or right brained). Understanding the origins of neuromyths is important, because it may relate to the strength of individuals’ belief in these myths. Therefore, it is important to determine whether remembering …

Friends Of Musselman Library Newsletter Fall 2019, Musselman Library

Friends of Musselman Library Newsletter

From the Dean (Robin Wagner)

Library News

• Cite and Bite Workshops
• Open Access Week (Janelle Wertzberger, Alecea Standlee, Hana Huskic)
• Notes at Noon
• Friends Sponsor Guild Participation (Mary Wootton)
• Stop the Bleed
• The Wall Must Go
• Story Time
• Table to Farm
• Pop-up Library
• Take the Reading Challenge
• 1,000,000
• Grant to Digitize Asian Art

Vietnam Oral Histories (Ron Bailey '67, Sue Hill '67, Michael Birkner, Devin McKinney)

Alexander von Humboldt's Secretary (William Bowman)

Focus on Philanthropy: Walter Miller Trust

A Gift in 3 Dimensions (Richard C. Ryder '70)

Remembering Richard Ryder '70 (Michael Birkner)

New Externship - Careers in Library and …

Neurotransmitter, Fall 2019, George Washington Institute For Neuroscience Neurological Institute, George Washington University Hospital

Neurotransmitter

No abstract provided.

Can And Should Universal Injunctions Be Saved?, Szymon S. Barnas

Vanderbilt Law Review

The practice of a federal district court judge halting the government's enforcement of an executive action against not only the parties before the court but against anyone, anywhere, may be coming to an end. Multiple Supreme Court Justices have expressed their skepticism in the propriety of universal injunctions. The growing scholarly consensus is that there should be a brightline rule against them. If the universal injunction's demise is impending and the class action's demise continues unabated, obtaining systemwide relief may be difficult when such relief may be most needed.

This Note considers whether universal injunctions can and should be saved. …

Artful Nature And The Legacy Of Maria Sibylla Merian, Emily N. Roush, Shannon R. Zeltmann, Felicia M. Else, Kay Etheridge, Shannon Egan

Schmucker Art Catalogs

The exhibition Artful Nature and the Legacy of Maria Sibylla Merian celebrates the skills and influences of a remarkable woman from seventeenth-century Europe. Curated by Emily Roush ’21 and Shannon Zeltmann ’21 with the guidance of Professors Kay Etheridge (Biology) and Felicia Else (Art History), Emily and Shannon selected the prints, organized them into categories, and carried out research on them, much of which was relatively obscure and would have been challenging even for graduate students.

Maria Sibylla Merian lived and worked in a time of vibrant intersections of art and science in Europe. Her images of insects and plants …

Understanding Evolutionary Relationships Between Sedges Genus Rhynocospora, Abidell T. Thomas

Honors Theses

The relationships among species in the genus Rhyncospora, a member of the flowering plant family Cyperaceae, are of value to study as they are essential plant components to our ecosystem. Sedges are necessary for wetland preservation, land-sea barriers, and in many cases serve as a natural water detoxifier. Rhyncospora is a prime genus to ask questions about their phylogeny because their evolutionary history is poorly understood for them to be so prevalent. To understand the relationships between a specific group of sedges (genus Rhyncospora) I utilized nucleotide sequence data in a phylogenetic approach. Phylogenetics is the study of …

Leaving Ligand Effects On Reactivity And Solubility Of Monofunctional Platinum(Ii) Anticancer Complexes, Heidi Linn Hruska Millay

Masters Theses & Specialist Projects

Monofunctional platinum(II) complexes, such as phenanthriplatin and pyriplatin, have notably different characteristics from the bifunctional anticancer complexes, such as cisplatin and oxaliplatin, which have detrimental toxicities and resistance associated with them. The unique properties of the monofunctional complexes may be exploited to target cancer cells without producing the toxic side effects associated with the current FDA-approved platinum-based anticancer drugs. To advance the understanding of these monofunctional platinum(II) complexes, this study replaced the chloride leaving ligand with an acetate group, which should increase solubility and alter the rate of reactivity with key amino acid and nucleotide targets. Phenanthriplatin and pyriplatin compounds …

Interaction Of A Platinum Triamine Complex Having A Seven-Membered Chelate Ring With N-Acetyl-Lmethionine And Guanosine 5'-Monophosphate, Jae Ko

Masters Theses & Specialist Projects

In the 1960s, Rosenberg and his colleagues confirmed the anti-cancer activity of cisplatin. Although cisplatin was capable of killing testicular cancer cells there were also serious side effects. It was necessary to find alternate ways of overcoming side effects, and soon many researchers have discovered novel platinum compounds that show similar reactivity. Recently, replacing one chloride group to a heterocyclic amine group showed significant cytotoxicity with a different binding activity than cisplatin. Previously in our lab, [Pt(Me5dien)(NO3)]+ and [Pt(Et2dien)Cl]+ have been synthesized and reacted with NAcetyl- L-methionine (N-AcMet) and Guanosine 5’-monophosphate (5’-GMP) showed unusual reactivity. Unlike most previously studied platinum …

Cultural Times, Multicultural Center

Newsletters

No abstract provided.

A Csra-Binding, Trans-Acting Srna Of Coxiella Burnetii Is Necessary For Optimal Intracellular Growth And Vacuole Formation During Early Infection Of Host Cells, Shaun Wachter, Matteo Bonazzi, Kyle Shifflett, Abraham S. Moses, Rahul Raghavan, Michael F. Minnick

Biological Sciences Faculty Publications

Coxiella burnetii is an obligate intracellular gammaproteobacterium and zoonotic agent of Q fever. We previously identified 15 small noncoding RNAs (sRNAs) of C. burnetii. One of them, CbsR12 (Coxiella burnetii small RNA 12), is highly transcribed during axenic growth and becomes more prominent during infection of cultured mammalian cells. Secondary structure predictions of CbsR12 revealed four putative CsrA-binding sites in stem loops with consensus AGGA/ANGGA motifs. We subsequently determined that CbsR12 binds to recombinant C. burnetii CsrA-2, but not CsrA-1, proteins in vitro. Moreover, through a combination of in vitro and cell culture assays, we identified several in trans mRNA …

Taking Laughter Seriously At The Supreme Court, Tonja Jacobi, Matthew Sag

Vanderbilt Law Review

Laughter in Supreme Court oral arguments has been misunderstood, treated as either a lighthearted distraction from the Court's serious work, or interpreted as an equalizing force in an otherwise hierarchical environment. Examining the more than nine thousand instances of laughter witnessed at the Court since 1955, this Article shows that the Justices of the Supreme Court use courtroom humor as a tool of advocacy and a signal of their power and status. As the Justices have taken on a greater advocacy role in the modern era, they have also provoked more laughter.

The performative nature of courtroom humor is apparent …

Multilevel Combinatorial Optimization Across Quantum Architectures, Hayato Ushijima-Mwesigwa, Ruslan Shaydulin, Christian F.A. Negre, Susan M. Mniszewski, Yuri Alexeev, Ilya Safro

Publications

Emerging quantum processors provide an opportunity to explore new approaches for solving traditional problems in the Post Moore's law supercomputing era. However, the limited number of qubits makes it infeasible to tackle massive real-world datasets directly in the near future, leading to new challenges in utilizing these quantum processors for practical purposes. Hybrid quantum-classical algorithms that leverage both quantum and classical types of devices are considered as one of the main strategies to apply quantum computing to large-scale problems. In this paper, we advocate the use of multilevel frameworks for combinatorial optimization as a promising general paradigm for designing hybrid …

Fuels Guide For Sagebrush And Pinyon-Juniper Treatments: 10 Years Post-Treatment, Samuel S. Wozniak, Eva K. Strand

Reports

Increased woody plant dominance and degraded understory vegetation are important issues on rangelands in the Intermountain West. Land managers implement woody plant reduction treatments of sagebrush (Artemisia spp.), juniper (Juniperus spp.), and pinyon pine (Pinus spp.) to increase understory diversity and cover, restore wildlife habitat, increase forage, improve ecosystem functions, and reduce or manipulate fuels to increase ecosystem resilience to fire and resistance to invasive annual grasses. Woody plant reduction treatments alter fuel orientation, continuity, and loading, and therefore have important implications for wildfire behavior, effects, and management. Currently, there is a lack of knowledge of the longer-term implications of …

Combining Ecological Niche Modeling With Genetic Lineage Information To Predict Potential Distribution Of Mikania Micrantha Kunth In South And Southeast Asia Under Predicted Climate Change, Achyut Kumar Banerjee, Abhishek Mukherjee, Wuxia Guo, Wei Lun Ng, Yelin Huang

Journal Articles

Ecological niche models (ENM), an effective tool to predict the potential distribution of invasive species, are often built on assumptions of niche conservatism between native and invasive ranges and genetic uniformity of the invasive population. In this study, we have incorporated genetic information with ENM to generate projected distribution of the invasive species Mikania micrantha for which two genetic clusters were identified in South and Southeast Asia. Climatic niches were compared between native and invasive ranges, as well as between invasive ranges of two lineages by using multivariate and univariate analyses. Ecological niche models were built with MaxEnt, using occurrence …

Author Correction: Probiotics And Prebiotics In Intestinal Health And Disease: From Biology To The Clinic (Nature Reviews Gastroenterology & Hepatology, (2019), 16, 10, (605-616), 10.1038/S41575-019-0173-3), Mary Ellen Sanders, Daniel J. Merenstein, Gregor Reid, Glenn R. Gibson, Robert A. Rastall

Probiotics, Health and Nutrition

© 2019, Springer Nature Limited. In the original article published online, the Competing Interests statement was incorrect and should have stated the following: M.E.S. declares personal fees related to probiotics from the following entities: California Dairy Research Foundation, Clorox, Danone, Danone USA, Dutch Mill, General Mills, JHeimbach, Kelley Drye & Warren, Kellogg, Kerry, Medscape, Nestle, New Chapter, Pepsico, Pfizer, Pharmavite, Probi, Procter & Gamble, Trouw Nutrition, Visalia Dairy Company, Williams Mullen, Winclove Probiotics and Yakult. D.J.M. declares personal fees for consulting for Bayer and Pharmavite. G.R. declares that he helped develop and commercialize probiotic strains GR-1 and RC-14, but has …

Probiotics And Prebiotics In Intestinal Health And Disease: From Biology To The Clinic, Mary Ellen Sanders, Daniel J. Merenstein, Gregor Reid, Glenn R. Gibson, Robert A. Rastall

Probiotics, Health and Nutrition

© 2019, Springer Nature Limited. Probiotics and prebiotics are microbiota-management tools for improving host health. They target gastrointestinal effects via the gut, although direct application to other sites such as the oral cavity, vaginal tract and skin is being explored. Here, we describe gut-derived effects in humans. In the past decade, research on the gut microbiome has rapidly accumulated and has been accompanied by increased interest in probiotics and prebiotics as a means to modulate the gut microbiota. Given the importance of these approaches for public health, it is timely to reiterate factual and supporting information on their clinical application …

Fear Of Humans As Apex Predators Has Landscape-Scale Impacts From Mountain Lions To Mice, Justin P. Suraci, Michael Clinchy, Liana Y. Zanette, Christopher C. Wilmers

Biology Publications

Apex predators such as large carnivores can have cascading, landscape-scale impacts across wildlife communities, which could result largely from the fear they inspire, although this has yet to be experimentally demonstrated. Humans have supplanted large carnivores as apex predators in many systems, and similarly pervasive impacts may now result from fear of the human ‘super predator’. We conducted a landscape-scale playback experiment demonstrating that the sound of humans speaking generates a landscape of fear with pervasive effects across wildlife communities. Large carnivores avoided human voices and moved more cautiously when hearing humans, while medium-sized carnivores became more elusive and reduced …

Which Components Of Processing Speed Are Affected In Adhd Subtypes?, Michelle Y Kibby, Sarah A Vadnais, Audreyana C Jagger-Rickels

Publications

The term "processing speed" (PS) encompasses many components including perceptual, cognitive and output speed. Despite evidence for reduced PS in Attention-Deficit/Hyperactivity Disorder (ADHD), little is known about which component(s) is most impacted in ADHD, or how it may vary by subtypes. Participants included 151 children, ages 8-12 years, with ADHD Predominantly Inattentive Type, ADHD Combined Type and typically developing controls using DSM-IV criteria. All children completed four measures of processing speed: Symbol Search, Coding, Decision Speed, and simple reaction time. We found children with ADHD-PI and ADHD-C had slower perceptual and psychomotor/incidental learning speed than controls and that ADHD-PI had …

Kahn Chronicle: Fall 2019, Smith College, Kahn Liberal Arts Institute

Kahn Chronicle

Table of Contents:

Faculty, Staff Invited to Apply for 2020-21 Yearlong Projects
2019-20 Short-term Projects Reflect Climate Change Theme
2019-20 Long-Term Projects: Student Fellowships Awarded
2020-21 Yearlong Project Descriptions
A Note from the Director

Fish & Wildlife News: Fall 2019, Matt Trott

Fish and Wildlife News

No abstract provided.

Gaining Access To The Language Of Science: A Research Partnership For Disciplined, Discursive Ways To Select And Assess Vocabulary Knowledge, H. Emily Hayden, Anupma Singh, Michelle Eades Baird

Reading Horizons: A Journal of Literacy and Language Arts

To equalize access to science learning across genders and demographic groups, access to the disciplinary language of science is one place to start. The language of science is highly challenging and specialized, and difficulties acquiring this language contribute to disparities in science achievement across diverse student groups. This study used a pre-post design to analyze effectiveness of a brief classroom science vocabulary assessment designed to assess receptive and productive vocabulary knowledge across multiple sections of one 7^th grade science teacher’s class. Vocabulary was selected and analysis conducted by an interdisciplinary research partnership including the science teacher, a literacy specialist, …

Stem Stories, October 2019, #1, Brooke Wiese

STEM Stories

Undergraduate Research - Mary Sutton

Impressions, Nova Southeastern University

Newsletters

No abstract provided.

Fall 2019

La Louisiane

The magazine of the University of Louisiana at Lafayette.