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Research News. Publications, 2019. Volume 3, University Of Mississippi. School Of Pharmacy, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period July 1 through September 30, 2019

Grand Challenges: A Way Out Of The Ivory Tower For Management Academic Discipline, Wojciech Czakon

European Management Studies

The academic discipline of management has a long and successful history of legitimacy building. Concerns about scientific rigor have brought major improvements in research, publication, and teaching practices. However, the established academic status fosters a rigor-relevance gap emerging between researchers and managers. Scholars are confined in metaphorical “ivory towers” of scientific rigor and orientation toward an academic audience, which disconnects the discipline from management practice. Consequently, both the social legitimacy of management academia and its development prospects are threatened. This study argues that management has a predilection to solving grand societal challenges, thus contributing both to social progress and discipline …

Investment Of Both Essential Fatty And Amino Acids To Immunity Varies Depending On Reproductive Stage, Taylor V. Pettit, R. John Pettit, Andrew M. Durso, Susannah S. French

Ecology Center Publications

Trade‐offs among the key life‐history traits of reproduction and immunity have been widely documented. However, the currency in use is not well‐understood. We investigated how reproducing female side‐blotched lizards, Uta stansburiana, allocate lipids versus proteins when given an immune challenge. We tested whether lizards would invest more in reproduction or immunity depending on reproductive stage. Females were given stable isotopes (¹⁵N‐leucine and ¹³C‐1‐palmitic acid), maintained on a regular diet and given either a cutaneous biopsy or a sham biopsy (control). Stable isotopes were monitored and analyzed in feces and uric acid, skin biopsies, eggs, and toe …

Bifunctional Helical Peptide Catalysts For Enzyme-Like Reactivity And Selectivity And Selective Stapling Of Natural Amino Acid Residues With Hydrophilic Squaric Acid Derivatives, Michael James Kinghorn

Theses and Dissertations

Peptide secondary structure provides an exceptional scaffold on which to design highly reactive and selective enzyme-like catalysts. This work describes the rational design and synthesis of a suite of helical peptide catalysts that are capable of achieving proximity-induced rate enhancement in Diels-Alder cycloadditions and indole alkylations. Microwave assisted synthesis of resin-supported polypeptides enables incorporation of non-natural amino acid residues that induce helicity (Aib) or provide functional handles on which organic catalytic residues can be attached. These small peptide catalysts exhibit binding-driven selectivity rather than relying on the inherent reactivity of substrates, which allows access to products that are not obtainable …

Small Island States Excluded From Climate Research When They Need It Most, N Higgs

School of Biological and Marine Sciences

No abstract provided.

Does Negativity Counterpoint Positivity, Or The Other Way Round? On Positive Organizational Scholarship, Aldona Glińska-Neweś, Beata Glinka

European Management Studies

Management science and organization theory is thriving, as evidenced by thousands of popular and academic publications exploring the subject, as well as a great number of conferences held in recent years. Every year new (and fashionable) concepts and theories are created and POS (Positive Organizational Scholarship) is among the most popular ones. Despite the advancement of the discipline, its current condition is criticised and considered disappointing This dissatisfaction stems from frustration caused by conflicting expectations of the community, i.e. business and other stakeholders, and of researchers themselves, and the impossibility of satisfying these demands. Failure to fulfil contradictory expectations generates …

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

The George-Anne, Georgia Southern University

The George-Anne

• Students Burn Book Outside of Eagle Village
• Book Burning History
• Open Forum Feud
• Protect the Nest
• Unburning Swamp
• Public Arriving
• Back on the Field
• New Eagle Shines Under Willis
• Trips to Vegas and Tulane Highlight the Newly Release Women's Basketball Schedule
• Homecoming 2019

A Newcomer's Guide To Functional Near Infrared Spectroscopy Experiments, Rand K. Almajidy, Kunal Mankodiya, Mohammadreza Abtahi, Ulrich G. Hofmann

Electrical, Computer, and Biomedical Engineering Faculty Publications

This review presents a practical primer for functional near-infrared spectroscopy (fNIRS) with respect to technology, experimentation, and analysis software. Its purpose is to jump-start interested practitioners considering utilizing a non-invasive, versatile, nevertheless challenging window into the brain using optical methods. We briefly recapitulate relevant anatomical and optical foundations and give a short historical overview. We describe competing types of illumination (trans-illumination, reflectance, and differential reflectance) and data collection methods (continuous wave, time domain and frequency domain). Basic components (light sources, detection, and recording components) of fNIRS systems are presented. Advantages and limitations of fNIRS techniques are offered, followed by a …

The Fatal Leviathan: A Hayekian Perspective Of Lex Mercatoria In Civil Law Countries, Fabio Núñez Del Prado Ch.

Pace International Law Review

Who should create default commercial rules? Should they be created in a constructivist way or should they be created rather through a spontaneous order? Should Kelsen’s positivism prevail in commercial law? Drawing on diverse libertarian literature, I will argue that, since courts do not play a dominant role in civil law countries and, more importantly, do not set precedents, default commercial rules should not be created by the legislator, but through the Lex Mercatoria.

Educational Life In The Interregnum: Race, Dis/Ability, And Special Education, Benjamin Kearl

Democracy & Education

This article undertakes a comparative analysis of special education policy through the juxtaposition of two recent Supreme Court actions: Allston v. Lower Merion School District (2015) and Endrew F. v. Douglas County School District (2017). This comparison reveals an ordering of special education policy around questions of race. Specifically, this article argues that special education policy is governed by a racecraft of disability labeling that defines students of color as variously disabled and through a biopolitics of special education that expands disability services for individual students who are within the truth demarcated by scientific-juridical mediations of life. Against such negative …

Unlocking Birth To Three: Context Really Matters, Hb Ebrahim

Occasional Paper Series

It is undisputed that birth to three are the foundational years where the youngest in our society experience extraordinary growth that contributes towards their development and learning. High quality programmes direct their efforts at building caring relationships, providing nurturing environments and working in partnerships with families and communities. Acting to develop responsive programmes and equitable practices, however, is not straightforward. Contestations have been brought to the fore by dissenting voices to mainstream narratives that privilege certain ways of knowing young children. In light of this, it is critical to ask: How has the dominant knowledge base for birth to three …

Antidepressant Dosing In Major Depression: A Pharmacogenomic Approach, Morgan Homan, Haval Norman, Victoria Cho, Yousif Rojeab

Pharmacy and Wellness Review

Major depressive disorder (MDD) is the most predominant mental disorder in the United States, with serious and costly health risks if not successfully managed. Pharmacotherapy is a standard option for MDD treatment, but patients often require extensive therapy adjustments to find a suitable regimen. Pharmacogenomics may enable greater precision in antidepressant therapy. Genotypic variations in CYP2D6 and CYP2C19 metabolic enzymes are reliable predictors of serum drug concentration, but the complex dose-response relationship of antidepressants prevents such variations from predicting therapy success. Additionally, ABCBl has been examined for its role in P-glycoprotein efflux of antidepressants in the brain, yet it is …

Use Of Botulinum Toxin In Central Nervous System Disorders, Julie Puvogel, Paige Torbet, Jourdan Ujlaki, Rebecca Worden, Lindsey Peters

Pharmacy and Wellness Review

Botulinum toxin is a neurotoxin that is produced by Clostridium botulinum. At one time, this toxin was only seen as a lethal substance, but now scientists have found many medical uses for it. There are eight distinctive toxins (A-H), but only A and B currently have clinical uses. Botulinum toxin A has three different versions that are U.S. Food and Drug Administration (FDA) approved: onabotulinumtoxinA (Botox®), abobotulinumtoxinA (Dysport®), incobotulinumtoxinA (Xeomin®). Botulinum toxin B is also FDA approved as rimabotulinumtoxinB (Myobloc®). The toxins work by inducing reversible, local, dose-dependent chemodenervation by inhibiting acetylcholine release from presynaptic terminals. These drugs are approved …

Hormonal Therapy And Preventive Care Of Transgender Patients, Angela Chu, Jana Randolph, Austin Hopkins, Victoria Cho, Sophocles Chrissobolis

Pharmacy and Wellness Review

Transgenderism occurs when an individual's gender identity conflicts with the individual's biological sex. A variety of methods may be used in order to reconcile this disparity in transgender individuals including psychological counseling, cross-sex hormone therapy and sex reassignment surgery. The most important role for pharmacists in the treatment of transgender patients is in dispensing hormonal medications for cross-sex treatment. Hormone therapy may be used to suppress characteristics of the patient's biological sex as well as to induce development of characteristics that correlate with the patient's gender identity. In male-to-female (MtF) transgender patients, the most commonly used medications include agents which …

Prevention And Treatment Of Glucocorticoid-Induced Osteoporosis, Mackenzie Devine, Anh Dao Le, Julie Puvogel, Victoria Cho, Michelle Musser

Pharmacy and Wellness Review

Osteoporosis is a disease state resulting in decreased bone mineral density (BMD) and increased risk of fracture, specifically of the vertebrae, spine and hip. Risk factors and high risk populations for developing osteoporosis include low BMD, long-term glucocorticoid therapy, genetics, diet, postmenopausal women and patients with inflammatory or chronic disease states. A variety of signaling pathways involving hormones, cytokines and other signaling molecules are involved in bone formation and are affected by long-term glucocorticoid therapy, leading to the development of glucocorticoid-induced osteoporosis (GIO).

There are a variety of drugs that work efficaciously to prevent and treat GIO. Alendronate is a …

Maternal And Infant Health Benefits Related To Infantile Feeding Methods, Michaela Wolford, Alexa Bouts, Carmen Lariccia, Cara Walden, Anh Dao Le, Andrew M. Roecker

Pharmacy and Wellness Review

Human breast milk is known to provide the most complete nutrition to growing infants. There may be more gained from breastfeeding than simply nutritional fulfillment-recent research has uncovered benefits related to the development and health of infants. Breastfeeding has been shown to stimulate immune system development by exposing the infant to bacteria and antibodies from the mother. Breastfeeding may also benefit nursing mothers by improving insulin sensitivity and glucose tolerance as well as decreasing postpartum weight gain. In place of breastfeeding, formulas are able to provide an infant with necessary nutrition. Many infant formulas have been enriched with probiotics and …

The Effect Of Cyp3a5 Polymorphism On Kidney Transplant Recipients Given Tacrolimus, Samia Alam, Sunitha Johns, Haval Norman, Brian Heilbronner, Yousif Rojeab

Pharmacy and Wellness Review

Tacrolimus, an immunosuppressant agent indicated for organ transplants, is commonly administered to reduce the risk of renal graft rejection in patients with chronic kidney disease (CKD) and end stage renal disease (ESRD). Due to its narrow therapeutic index and high inter-patient variability, studies have suggested that CYP3A5-based dosing provides specialized regimens which may significantly improve the chances of achieving therapeutic concentrations. According to the Clinical Pharmacogenetics Implementation Consortium (CPIC) recommendations, extensive (CYP3A5*1/*1) and intermediate metabolizers (CYP3A5*1/*3) require a higher initial dose while poor metabolizers (CYP3A5*3/*3) require a lower initial dose in order to achieve target tacrolimus concentrations. Studies concluded that …

Zika Virus Induced Neurological Disorders And Impacts On Public Health, Alexandra Herman, Martha Zimmerman, Olivia Vanscoy, Olivia Henton, Lindsey Peters

Pharmacy and Wellness Review

Zika virus is a public health emergency of international concern. Zika virus (ZIKV) is a mosquito-borne pathogen that is carried by the Aedes genus. Zika is spread through direct bite and nonvector transmission. Most individuals infected with Zika will be asymptomatic, but some may present nonspecific viral symptoms. A rising number of neurological disorders in newborns whose mothers were infected with ZIKV during pregnancy have been reported due to recent outbreaks. Neurological disorders affect both the central and peripheral nervous systems and can result from bacterial, viral, fungal or parasitic infections of the nervous system or from the immune response …

Circulating Obesity-Driven Biomarkers Are Associated With Risk Of Clear Cell Renal Cell Carcinoma: A Two-Stage, Case-Control Study, Qinchuan Wang, Huakang Tu, Meiling Zhu, Dong Liang, Yuanqing Ye, David W. Chang, Yin Long, Xifeng Wu

Faculty Publications

Obesity is one of modifiable risk factors for clear cell renal cell cancer (ccRCC). We aim to identify the association between obesity-driven biomarkers and ccRCC risk. This is a retrospective, two-phase, case-control study involving 682 cases and 733 controls. Obesity-driven biomarkers [gastric inhibitory polypeptide (GIP), C-peptide, insulin, resistin, adipsin, peptide YY, pancreatic polypeptide, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), plasminogen activator inhibitor-1, monocyte chemoattractant protein 1, lipocalin2, leptin, adiponectin] were measured using the Milliplex method. Multivariate logistic regression was used to assess the associations between biomarkers and ccRCC risk. Results revealed that GIP, C-peptide, IL-6 and TNF-α levels were consistently …

October 16th, 2019, Csusb

Coyote Chronicle (1984-)

Inside This Issue

• ICE Pg. 3
• Vox Pop: Life Lessons Pg. 4
• Sports Calendar Pg. 6

Introduction To Ecological Data Analysis Bio 263, Michael Cerbo

Library Impact Statements

No abstract provided.

Protein Inter-Residue Distance Prediction Using Residual And Capsule Networks, Andrew Dillon

Theses

The protein folding problem, also known as protein structure prediction, is the task of building three-dimensional protein models given their one-dimensional amino acid sequence. New methods that have been successfully used in the most recent CASP challenge have demonstrated that predicting a protein's inter-residue distances is key to solving this problem. Various deep learning algorithms including fully convolutional neural networks and residual networks have been developed to solve the distance prediction problem. In this work, we develop a hybrid method based on residual networks and capsule networks. We demonstrate that our method can predict distances more accurately than the algorithms …

We Are...Marshall, October 16, 2019, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Current Understanding Of West Nile Virus Clinical Manifestations, Immune Responses, Neuroinvasion, And Immunotherapeutic Implications, Fengwei Bai, E. Ashley Thompson, Parminder J.S. Vig, A. Arturo Leis

Faculty Publications

West Nile virus (WNV) is the most common mosquito-borne virus in North America. WNV-associated neuroinvasive disease affects all ages, although elderly and immunocompromised individuals are particularly at risk. WNV neuroinvasive disease has killed over 2300 Americans since WNV entered into the United States in the New York City outbreak of 1999. Despite 20 years of intensive laboratory and clinical research, there are still no approved vaccines or antivirals available for human use. However, rapid progress has been made in both understanding the pathogenesis of WNV and treatment in clinical practices. This review summarizes our current understanding of WNV infection in …

Uab's Cimino Wins Prestigious Informatics Award, Alicia Rohan

Browse All News

No abstract provided.

Four Uab Women Receive American Association Of University Women Fellowships And Grant, Alicia Rohan

Browse All News

No abstract provided.

A Genome-Wide Assessment Of The Ancestral Neural Crest Gene Regulatory Network, Dorit Hockman, Vanessa Chong-Morrison, Stephen A. Green, Daria Gavriouchkina, Ivan Candido-Ferreira, Irving T. C. Ling, Ruth M. Williams, Chris T. Amemiya, Jeramiah J. Smith, Marianne E. Bronner, Tatjana Sauka-Spengler

Biology Faculty Publications

The neural crest (NC) is an embryonic cell population that contributes to key vertebrate-specific features including the craniofacial skeleton and peripheral nervous system. Here we examine the transcriptional and epigenomic profiles of NC cells in the sea lamprey, in order to gain insight into the ancestral state of the NC gene regulatory network (GRN). Transcriptome analyses identify clusters of co-regulated genes during NC specification and migration that show high conservation across vertebrates but also identify transcription factors (TFs) and cell-adhesion molecules not previously implicated in NC migration. ATAC-seq analysis uncovers an ensemble of cis-regulatory elements, including enhancers of Tfap2B, …

The Attributes Of Emotional Intelligence And Its Impact On Academic Performance, Zeinab Shawky Younis

Business Administration

There is a debate of whether Emotional Intelligence is born or made when it comes to the field of higher education and students ‘academic performance The question that arises is: whether students should build on their practical and analytical knowledge transferred by theory only or they should acquire more Emotional Intelligence skills? The new paradigm of thinking encompasses creative and Emotional Intelligence as essential building blocks in most organisations. The current competitive environment implies on students to perform multiple tasks with efficiency and effectiveness, their academic knowledge and theory only will not help facing challenges but their right attitude and …

Treatment Patterns And Economic Burden Of Sickle-Cell Disease Patients Prescribed Hydroxyurea: A Retrospective Claims-Based Study, Nirmish Shah, Menaka Bhor, Lin Xie, Rashid Halloway, Steve Arcona, Jincy Paulose, Huseyin Yuce

Publications and Research

Background: This study aimed to evaluate sickle-cell disease (SCD) treatment patterns and economic burden among patients prescribed hydroxyurea (HU) in the US, through claims data.

Methods: SCD patients with pharmacy claims for HU were selected from the Medicaid Analytic Extracts (MAX) from January 1, 2009 - December 31, 2013. The first HU prescription during the identification period was defined as the index date and patients were required to have had continuous medical and pharmacy benefits for ≥6 months baseline and 12 months follow-up periods. Patient demographics, clinical characteristics, treatment patterns, health care utilization, and costs were examined, and variables were …