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Extracellular Matrix In Development And Disease, Julia Thom Oxford, Jonathon C. Reeck, Makenna J. Hardy

Biomedical Research Institute Publications and Presentations

The evolution of multicellular metazoan organisms was marked by the inclusion of an extracellular matrix (ECM), a multicomponent, proteinaceous network between cells that contributes to the spatial arrangement of cells and the resulting tissue organization. The development of an ECM that provides support in larger organisms may have represented an advantage in the face of selection pressure for the evolution of the ECM.

Concise Review: Stem Cell Therapy For Stroke Patients: Are We There Yet?, Cesar V. Borlongan

Neurosurgery and Brain Repair Faculty Publications

Four decades of preclinical research demonstrating survival, functional integration, and behavioral effects of transplanted stem cells in experimental stroke models have provided ample scientific basis for initiating limited clinical trials of stem cell therapy in stroke patients. Although safety of the grafted cells has been overwhelmingly documented, efficacy has not been forthcoming. Two recently concluded stroke clinical trials on mesenchymal stem cells (MSCs) highlight the importance of strict adherence to the basic science findings of optimal transplant regimen of cell dose, timing, and route of delivery in enhancing the functional outcomes of cell therapy. Echoing the Stem Cell Therapeutics as …

Microrna-133a And Myocardial Infarction, Yi Xiao, Jiling Zhao, Julian P. Tuazon, Cesar V. Borlongan, Guolong Yu

Neurosurgery and Brain Repair Faculty Publications

Myocardial infarction (MI) is the leading cause of morbidity and mortality in the world. The infarcted heart displays typical cell death cascades characterized by a loss of cells and fibrotic scarring in the myocardium. Cardiac hypertrophy and fibrosis largely contribute to ventricular wall thickening and stiffening, altogether defining an adverse cardiac remodeling that ultimately leads to impaired cardiac function and subsequent heart failure. Finding a strategy to promote therapeutic, instead of detrimental, cardiac remodeling may pose as a potent MI treatment. Accumulating evidence shows that microRNAs (miRNAs) may play an essential role in cardiovascular diseases. In particular, microRNA-133a (miR-133a) is …

Immunomodulation With Human Umbilical Cord Blood Stem Cells Ameliorates Ischemic Brain Injury – A Brain Transcriptome Profiling Analysis, Maple L. Shiao, Ce Yuan, Andrew T. Crane, Joseph P. Voth, Mario Juliano, Laura L. Hocum Stone, Zhenghong Nan, Ying Zhang, Nicole Kuzmin-Nichols, Paul R. Sanberg, Andrew W. Grande, Walter C. Low

Neurosurgery and Brain Repair Faculty Publications

Our group previously demonstrated that administration of a CD34-negative fraction of human non- hematopoietic umbilical cord blood stem cells (UCBSC) 48 h after ischemic injury could reduce infarct volume by 50% as well as significantly ameliorate neurological deficits. In the present study, we explored possible mechanisms of action using next generation RNA sequencing to analyze the brain transcriptome profiles in rats with ischemic brain injury following UCBSC therapy. Two days after ischemic injury, rats were treated with UCBSC. Five days after administration, total brain mRNA was then extracted for RNAseq analysis using Illumina Hiseq 2000. We found 275 genes that …

Global Behavior Of A New Rational Nonlinear Higher-Order Difference Equation, Wen-Xiu Ma

Mathematics and Statistics Faculty Publications

Let be a nonnegative integer and a real number greater than or equal to 1. We present qualitative global behavior of solutions to a rational nonlinear higher-order difference equation with positive initial values , and show the global asymptotic stability of its positive equilibrium solution.

Through The Looking Glass: Donald Trump, Heteronormativity And Homosociality, Jessica Mei

2019 Claremont Colleges Library Undergraduate Research Award

My research focuses on how society constructs gender and sexuality by analyzing how both academics and the media react to Donald Trump’s deviations from normative, hyper-masculine behavior. Currently, society reads his non-normative rhetoric and actions through a heteronormative lens and therefore characterize him as a homosexual. I believe this characterization is both demeaning to the queer community and also not accurate. Instead, it is clear to me that his deviations mark him as having homosocial tendencies, which is more accurate and less problematic.

Preferences Of Specialist And Generalist Mammalian Herbivores For Mixtures Versus Individual Plant Secondary Metabolites, Jordan D. Nobler, Jennifer S. Forbey

Biology Faculty Publications and Presentations

Herbivores that forage on chemically defended plants consume complex mixtures of plant secondary metabolites (PSMs). However, the mechanisms by which herbivores tolerate mixtures of PSMs are relatively poorly understood. As such, it remains difficult to predict how PSMs, singly or as complex mixtures, influence diet selection by herbivores. Although relative rates of detoxification of PSMs have been used to explain tolerance of PSMs by dietary specialist herbivores, few studies have used the rate of detoxification of individual PSMs to understand dietary preferences of individual herbivores for individual versus mixtures of PSMs. We coupled in vivo experiments using captive feeding trials …

Coding Sequences Of Sarcoplasmic Reticulum Calcium Atpase Regulatory Peptides And Expression Of Calcium Regulatory Genes In Recurrent Exertional Rhabdomyolysis, Stephanie J. Valberg, Kaitlin Soave, Zoe J. Williams, Sudeep Perumbakkam, Melissa Schott, Carrie J. Finno, Jessica L. Petersen, Clara Fenger, Joseph M. Autry, David D. Thomas

Department of Animal Science: Faculty Publications

Background: Sarcolipin (SLN), myoregulin (MRLN), and dwarf open reading frame (DWORF) are transmembrane regulators of the sarcoplasmic reticulum calcium transporting ATPase (SERCA) that we hypothesized played a role in recurrent exertional rhabdomyolysis (RER).

Objectives: Compare coding sequences of SLN, MRLN, DWORF across species and between RER and control horses. Compare expression of muscle Ca²⁺ regulatory genes between RER and control horses.

Animals: Twenty Thoroughbreds (TB), 5 Standardbreds (STD), 6 Quarter Horses (QH) with RER and 39 breed-matched controls.

Methods: Sanger sequencing of SERCA regulatory genes with comparison of amino acid (AA) …

Yes-Associated Protein 1 Is Required For Proliferation And Function Of Bovine Granulosa Cells In Vitro, Michele R. Plewes, Xiaoying Hou, Pan Zhang, Aixin Liang, Guohua Hua, Jennifer R. Wood, Andrea S. Cupp, Xiangmin Lv, Cheng Wang, John S. Davis

Department of Animal Science: Faculty Publications

Yes-associated protein 1 (YAP1) is a major component of the Hippo signaling pathway. Although the exact extracellular signals that control the Hippo pathway are currently unknown, increasing evidence supports a critical role for the Hippo pathway in embryonic development, regulation of organ size, and carcinogenesis. Granulosa cells (GCs) within the ovarian follicle proliferate and produce steroids and growth factors, which facilitate the growth of follicle and maturation of the oocyte.We hypothesize that YAP1 plays a role in proliferation and estrogen secretion of GCs. In the current study, we examined the expression of the Hippo signaling pathway in bovine ovaries and …

Postnatal Β2 Adrenergic Treatment Improves Insulin Sensitivity In Lambs With Iugr But Not Persistent Defects In Pancreatic Islets Or Skeletal Muscle, Dustin T. Yates, Leticia E. Camacho, Amy C. Kelly, Leah V. Steyn, Melissa A. Davis, Andrew T. Antolic, Miranda J. Anderson, Ravi Goyal, Ronald E. Allen, Klearchos K. Papas, William W. Hay Jr, Sean W. Limesand

Department of Animal Science: Faculty Publications

Placental insufficiency causes intrauterine growth restriction (IUGR) and disturbances in glucose homeostasis with associated β adrenergic receptor (ADRβ) desensitization. Our objectives were to measure insulin-sensitive glucose metabolism in neonatal lambs with IUGR and to determine whether daily treatment with ADRβ2 agonist and ADRβ1/β3 antagonists for 1 month normalizes their glucose metabolism. Growth, glucose-stimulated insulin secretion (GSIS) and glucose utilization rates (GURs) were measured in control lambs, IUGR lambs and IUGR lambs treated with adrenergic receptor modifiers: clenbuterol atenolol and SR59230A (IUGR-AR). In IUGR lambs, islet insulin content and GSIS were less than …

The Heritability Of Pampiniform Plexus Vessel Size And Varicocoele In Boars, Tasha R. Gruhot, Lea A. Rempel, Matthew L. Spangler, Stephen D. Kachman, Benny E. Mote

Department of Animal Science: Faculty Publications

Ultrasonography was used to capture a coronal–sagittal image of the veins of the pampiniform plexus (PP) and the testicular artery of 327 maternal‐line boars at approximately 6 months of age at the University of Nebraska—Lincoln. Varicocoele was diagnosed by two methods. Method 1 diagnosed varicocoele when the average vessel area on one side of the scrotum was 1.5 times larger than the average vessel area on the other side of the scrotum. Method 2 diagnosed varicocoele when the average vessel area on one side of the scrotum of a boar was 1.5 times larger than the average vessel on the …

Adaptation Strategies: Ruminants, John B. Gaughan, Veerasamy Sejian, Terry L. Mader, Frank R. Dunshea

Department of Animal Science: Faculty Publications

• Growing populations and reduced access to arable land mean that animal production systems will either need to intensify and/or produce more from a reducing land and other resource base.

• Variable and unpredictable environmental conditions mean that animal production faces numerous challenges. In add- ition to climate, these challenges include increased disease risk, increased nutritional deficiencies, and lack of capital to support diversification.

• Predicted changes in climate will impose selection pressures on traits important for biological fitness (and production).

• Genetic adaptation is important for the future of livestock systems. Animal adaptation involves trade-offs, which must be considered when selecting animals for …

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Livestock Animals To Study Infertility In Women, Mohamed A. Abedal-Majed, Andrea S. Cupp

Department of Animal Science: Faculty Publications

• Anovulation is a major cause of infertility in mammalian females.

• Ovarian research in humans is challenging due to the shortage of “normal tissue” that can be obtained from women that are trying to get pregnant.

• Livestock animals provide valuable resources to investigate the optimal intra-follicular environment required to facilitate folliculogenesis and translate to humans.

• Different livestock models may be more useful depending on the specific biological process studied.

Changes In North American Mammal Niche Preferences From The Late Pleistocene To The Present, Silvia Pineda-Munoz, Anikó Tóth, S. Kathleen Lyons, Yue Wang, Jenny Mcguire

School of Biological Sciences: Presentations

Human population has exponentially grown since the last glaciation, especially across temperate areas with easy access to water sources, excluding mammal species from their former habitats. Thus, we anticipate a change in environmental niche preferences for temperature and precipitation as increased human population forces mammal species into more extreme climates within their environmental tolerances. For our study, we collected species occurrences from 20,000 ybp to the present for 59 North American mammal species. We inferred temperature and precipitation for each location using paleoclimate simulations (CCSM3). Overall, we found that mammals now live in areas that are warmer and dryer on …

Medical Errors / Patient Safety: Hospital Medication Errors Pre- & Post-Electronic Health Records (Ehr) / Meaningful Use Act, Emmanuel C. Chukwudi

MUSC Theses and Dissertations

The current dissertation study analyzes whether the volume of medication errors in which years prior to the adoption and implementation of the HITECH / Meaningful Use Act or the EHR (2007-2010) was higher, lower, or remained unchanged versus in which years after implementation of the Meaningful Use Act / HITECH Act (2011-2014). The study employed secondary data sources from the Center for Drug Evaluation and Research (CDER) / Healthcare Cost and Utilization Project (HCUP). A time series analysis was used to assess the effect of the regulation implementation. Purpose: Medical errors ranked as the third top leading cause of all …

“It’S Like A Big Freaking Fake Circus”: An Exploration Of Intersectionality And Women’S Experiences In Higher Education Fundraising, Daniel Mathis Spadafore

Master's Theses and Doctoral Dissertations

Women in higher education fundraising navigate the broad forces of sexism and racism in society and their profession, a profession in which they are being paid less than their male counterparts and are under-represented in leadership roles, despite being the majority of fundraising professionals. This study provided a platform for women in higher education fundraising to tell their stories and to explain, in their own words, how they navigated a traditionally White patriarchal system of philanthropy, interacted with fundraising prospects and donors, and experienced the fundraising profession. The research questions included:

• What do women say are their lived experiences …

Understanding The Role Of Atg7 And Atg14 In Autophagy, Ronith Chakraborty

Senior Honors Theses and Projects

Autophagy is the process by which cytosolic components are trafficked to and degraded by the vacuole or lysosome. It plays a critical role in cellular health, aging, cancer, and neurodegenerative diseases. Atg7 and Atgl4 are enzymes required for the autophagic process in Saccharomyces cerevisiae. In this study, we hypothesized that Atg7 controls the size while Atg 14 controls the number of autophagosomes. Using western blotting, Pho8D.60 assay and transmission electron microscopy analysis, we found that Atg7 affects both the size and number of autophagosomes. In addition, we have created cells expressing various levels of Atgl4 using non-native promoters. In addition, …

Handling George Eliot’S Fiction, Peter J. Capuano

Department of English: Faculty Publications

An argument that George Eliot was a novelist intellectually, philosophically, and aesthetically ahead of the majority of her peers thankfully needs no defense two hundred years after her birth. This lofty status, however, does not mean that Eliot was impervious to the cultural preoccupations of her time. Quite the contrary. A central contention of this essay is that Eliot, despite her imposing intellectual reputation, engaged with her culture’s popular interest in human hands in ways that profoundly affected her fiction. As I have argued elsewhere,¹ the Victorians became highly cognizant of the physicality of their hands in large part …

Orda Weekly Update, 2019 08 05, Office Of Research Development And Administration

ORDA Weekly Update

No abstract provided.

Orda Weekly Update, 2019 06 17, Office Of Research Development And Administration

ORDA Weekly Update

No abstract provided.

Orda Weekly Update, 2019 04 01, Office Of Research Development And Administration

ORDA Weekly Update

No abstract provided.

Companion Animal Ectoparasites, Jennifer Furchak

Department of Entomology: Distance Master of Science Projects

Fleas 3

Ticks 6 Brown Dog Tick 7 American Dog Tick 8 Black-legged Tick 9 Lone Star Tick 10 Gulf Coast Tick 11

Mosquitoes 13

Parasite Comparison 15

Control and Prevention 16

Active Ingredients 19

Integrated Pest Management 20

Resources for Pet Parents 21

References 22

Lesson Plan: Bug Basics, Kelsey Larsen

Department of Entomology: Distance Master of Science Projects

Grades: Pre-K & Kindergarten

Time Frame of Instruction: 40-45 minutes

What Skill Are Being Taught? Through hands-on and listening activities, student should be able to: Identify common insects by sight and sound. Recognize difference between an insect and other bugs such as spiders, centipedes, etc. - Differences should include but not limited to the number of body parts & legs (main way to distinguish between an insect, spider, etc.)

Educational Components of Classroom Project: 1. Science: Students will learn the basics about insect biology and how to identify common “bugs” 2. Visual: Students will be able handle plastic bugs in …

Building An Integrated Pest Management Plan For A Unique Urban Farming Program, Jeff Coco

Department of Entomology: Distance Master of Science Projects

The summer of 2018 led to an opportunity with a local non-profit called Fleet Farming. This non-profit had different departments available for internships which included greenhouse and farming. I was familiar with the program in that I knew they farmed in people’s front yards, in ‘farmlettes’ that had been converted from lawns. I was most interested in the job description under farming that said “practicing IPM”. I had developed an interest in IPM when I took Dr. Tom Weissling’s class on the Management of horticultural crop insects in the Spring of 2018. I wanted more ‘hands on’ learning and this …

Undergraduate Symposium, 2019, College Of Arts & Sciences

Undergraduate Symposium Programs

No abstract provided.

Size Estimation Of Pre‐Columbian Caribbean Fish, Sandrine Grouard, Sophia Perdikaris, Nídia Cristina Espíndola Rodrigues, Irvy R. Quitmyer

School of Global Integrative Studies: Faculty Publications

In this contribution, we present a methodological approach to the identification of pre‐Columbian Caribbean fisheries and examine the interrelationships of exploitation according to size for eight fish families, in a diachronic perspective for the Lesser Antilles. Based on the principles of size and growth allometries, biometric repositories have been reconstructed for modern families that represent different ecological environments: Holocentridae, Serranidae, Carangidae, Lutjanidae, Haemulidae, Scaridae, Acanthuridae, and Scombridae. The measured fish bone elements were selected based on their robustness and potential for recovery at archaeological sites. This resulted in a sample size totaling 563 modern osteological specimens, which provided reconstructed standard, …

Wpa News 110 (2019), World Pheasant Association

Galliformes Specialist Group and Affiliated Societies: Newsletters

WPA News (Winter 2019), number 110

Published by the World Pheasant Association

Outcomes Of The Iowa Parent Partner Program Evaluation: Stability Of Reunification And Re-Entry Into Foster Care, Jeff M. Chambers, Sandy Lint, Maggie G. Thompson, Matthew W. Carlson, Michelle Graef

Center on Children, Families, and the Law: Faculty Publications

In an effort to facilitate family engagement with services, improve reunification outcomes, and empower the families they serve, child welfare agencies across the country have developed and implemented programs designed to provide peer mentoring. These programs work to identify parents who have successfully navigated the child welfare system in the past and train them to mentor parents who are currently in the system. The current study used a quasi-experimental design and propensity score matching to examine the outcomes for children of families served by the Iowa Department of Human Services Parent Partner program, one of the earliest and most established …

A Descriptive Study Of Some Trifolium L. (Clover) Taxa Grown In Bolu Province, Emel Uslu, Mehmet Teki̇n Babaç

Turkish Journal of Botany

Micromorphological characteristics of 13 Trifolium species, which are grown in the province of Bolu, were examined using a scanning electron microscope (SEM). The morphological characteristics determined from the study were subjected to morphometric analyses and their variation spectrums were defined. Tricolporate pollen grains showed two pollen shapes, prolate and subprolate, according to equatorial view. The smallest size of polar axis length (18.00 μm) was found in T. micranthum Viv. from section Chronosemium Ser.; the largest (88.95 μm) was found in T. hirtum All. from section Trifolium L.. Statistically, the smallest seeds were found in T. resupinatum L. from the section …

Constitutionally Incapable: Parole Boards As Sentencing Courts, Mae C. Quinn

Journal Articles

Courtroom sentencing, as part of the judicial process, is a long-standing norm in the justice system of the United States. But this basic criminal law precept is currently under quiet attack. This is because some states are now allowing parole boards to step in to decide criminal penalties without first affording defendants lawful judicial branch sentencing proceedings and sentences. These outside-of-court punishment decisions are occurring in the cases of youthful offenders entitled to sentencing relief under Miller v. Alabama, which outlawed automatic life-without-parole sentences for children. Thus, some Miller-impacted defendants are being sentenced by paroleboards as executive branch agents, rather …