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Computer Image Analysis Based Quantification Of Comparative Ihc Levels Of P53 And Signaling Associated With The Dna Damage Repair Pathway Discriminates Between Inflammatory And Dysplastic Cellular Atypia, Mark Richard Rutenberg

ETD Archive

Epithelial oncogenesis is believed to be generally associated with the accumulation over time of an increasing number of mitotic errors until a threshold number of mutations required for the initiation of cancer is achieved. Preemption of cancer through the morphologic detection of dysplastic cells, i.e. cells with a number of mitotic errors that are still below the threshold for cancer, followed by their surgical removal or eradication, has had an enormous impact on reducing the incidence of cancer of the uterine cervix, skin and colon worldwide, but this strategy has been much less successful with cancers in most other body …

Development Of An Spr Method To Monitor The Chemical Interaction Of Dna With A Small Reactive Molecule: Peroxynitrite As An Example, Divya Sharma

ETD Archive

Peroxynitrite is an anion with the formula ONOO-. It is an unstable structural isomer of nitrate, NO3-. Although its conjugate acid (ONOOH) is highly reactive, it is quite relatively stable in basic solutions. Generation of peroxynitrite in-vivo occurs through the diffusion-controlled reaction between superoxide anion and nitric oxide free radical. It is a strong oxidizing and nitrating agent, and its formation has been correlated with many pathological conditions. Because of its oxidizing properties, peroxynitrite can damage a wide array of molecules in cells, including DNA and proteins. Reactions of peroxynitrite with DNA, proteins, and lipids, trigger a wide array of …

Validation Of Esens Pressure Sensor Array During Walking And Running, Nicolas Matthew Chambers

ETD Archive

The eSens Pressure Sensor Array is a prototype device aimed at quantifying the spatiotemporal measurements obtained during walking or running. The objective of the present investigation was to validate the spatiotemporal measurements from the eSens against those of the PKMAS walkway. Twenty-four adults with a mean age of 40.72 years completed the study. Mean group height and weight were 66.64in and 152.48lb respectively. Subjects performed a series of 6 locomotor conditions consisting of 3 differing walking or running speeds. Subjects were asked to walk or run at the instructed speed along a course constructed of markers at 5m or 10m …

Usft 2019-2020 Usf Libraries Annual Report, Usf Libraries

Library Annual Reports

No abstract provided.

Liquid Chromatography - Mass Spectrometric Analysis Of Clinicallyand Pharmacologically Relevant Molecules, Raghavi Kakarla

ETD Archive

Liquid Chromatography-Mass Spectrometry is an advanced analytical technique that offers high sensitivity and specificity and has been increasingly used for analysis of a wide variety of compounds including clinically and pharmacologically relevant molecules. In this dissertation we describe qualitative and quantitative liquid chromatographic mass spectrometric methods to analyze both small molecules and larger macromolecules that provide useful insights into diagnosis and management of several diseases. An LCMS(/MS) analytical method includes extraction of analytes of interest from the matrix followed by liquid chromatographic separation and mass spectrometric detection. Chapter I describes pre-analytical workflows and sample pretreatment techniques and theories underlying LC-MS …

Role Of Tumor Necrosis Factor-Stimulated Gene-6 In Cutaneous Wound Healing And Inflammation, Sajina Shakya

ETD Archive

Controlled inflammation is crucial for normal wound healing. Our main aim in this study was to investigate the effect of loss of tumor necrosis factor-stimulated gene-6 (TSG-6) in cutaneous wound closure and inflammation. TSG-6 by its enzymatic action modifies the extracellular matrix molecule, hyaluronan (HA), through the transfer of heavy chain (HC) proteins from inter-a-trypsin inhibitor to form HC-HA complexes. Both TSG-6 and HC-HA have been associated with inflammation. Here, we showed that loss of endogenous TSG-6 and HC-HA in TSG-6 null mice results in significantly delayed wound closure and differential neutrophil recruitment compared to wildtype mice. Both of these …

The Critical Review Of Overuse Of Medication In The Geriatric Population, Sophia A. Allwood

All Electronic Theses and Dissertations

Background: The overuse of medications is of concern among the geriatric population, especially in various settings including in-home and community-based (assisted living and independent living). This review found that older individuals take nine or more medications daily. The overuse of medications has an increased tendency to cause problems for older patients and creates adverse consequences. The adverse consequences cause problems and injuries, such as broken bones, head trauma, and death. Purpose: The purpose of this critical review of the literature is to investigate the issues related to the overuse of medication in the geriatric population and the negative impact of …

Nutrition Education For The Underserved Youth Within The Greater Twin Cities Area Through The Insports Foundation, Paige D. Deters, Allison Kaper, Maura Romanshek

All Electronic Theses and Dissertations

It has been examined that poor access to nutritious foods and limited opportunities for physical activity is prevalent among children from underserved families. These deficiencies contribute to increasing childhood obesity rates and emphasize the need for early interventions. Establishing nutritional literacy and understanding the importance of an active lifestyle in early childhood can lead to long-term health benefits and reduction in chronic disease later in life (HHS & USDA, 2015; Tsai et al., 2011; Wang et al., 2011). The InSports Foundation serves as a comprehensive non-profit organization that addresses many of these issues by providing children from underserved families with …

Prevalence Of Mental Health Stigma Among Practicing Pas In Regard To Personal Experience And Patient Exposure, Bailey J. Hanson, Allison Hoy, Madeline Lieberson

All Electronic Theses and Dissertations

Stigmatizing attitudes can be destructive to both the emotional and physical wellbeing of individuals living with mental illness. In fact, individuals with a mental illness are more likely to be seen as responsible for their illness and more likely to be falsely accused of a violent crime (Rüsch, Angermeyer, & Corrigan, 2005). Current research on mental health stigma in healthcare has involved a variety of occupations, but published research has yet to examine stigma held by physician assistants (PAs). This research study attempted to answer the following question: What effect, if any, does personal experience with a family member, friend, …

Southeastern Alumni Magazine- Winter 2019, Southeastern University - Lakeland

Southeastern Alumni Magazine

This issue features alumni from the College of Education.

AMERICAN CENTER FOR POLITICAL LEADERSHIP Former U.S. Congressman Dennis Ross joins SEU as a distinguished professor of political science to launch the American Center for Political Leadership, a bipartisan center.

SEU LAUNCHES AVIATION PROGRAM In partnership with the International Aero Academy, Ltd., SEU announced the launch of an innovative, cost-effective new aviation program that will meet the current and anticipated need for professional pilots.

CHRISTY (CLEMENTS) PAVILANDO: CLIENT RELATIONS FOR THE JACKSONVILLE JAGUARS As a member experience specialist for the Jacksonville Jaguars NFL football team, Christy ’16 is a key player …

Religious Support, United States Army

United States Army: Field Manuals

Religious Support, United States Army Field Manual FM 1-05

Army Support To Military Deception, United States Army

United States Army: Field Manuals

Army Support to Military Deception, United States Army Field Manual FM 3-13.4

Sustainment Operations, United States Army

United States Army: Field Manuals

Sustainment Operations, United States Army Field Manual FM 4-0

Faculty Teaching And Librarian-Facilitated Assignment Design, Rachel Wishkoski, Kacy Lundstrom, Erin Davis

Library Faculty & Staff Publications

This qualitative study explores the impact of a workshop on collaborative research assignment design that brought together an interdisciplinary group of faculty in a librarian-facilitated community of practice. Faculty participants attended the workshop, revised and implemented their assignments, and completed a follow-up interview. Themes that emerged reflected shifts in faculty teaching practices, including increased scaffolding, clarity, modeling, student collaboration, and opportunities for authentic learning. Gaining insight into how faculty approach the work of teaching directly impacts library instruction and how librarians can contribute to communities of practice among teachers in the academy.

Synergy Of Physics-Based Reasoning And Machine Learning In Biomedical Applications: Towards Unlimited Deep Learning With Limited Data, Valeriy Gavrishchaka, Olga Senyukova, Mark Koepke

Faculty & Staff Scholarship

Technological advancements enable collecting vast data, i.e., Big Data, in science and industry including biomedical field. Increased computational power allows expedient analysis of collected data using statistical and machine-learning approaches. Historical data incompleteness problem and curse of dimensionality diminish practical value of pure data-driven approaches, especially in biomedicine. Advancements in deep learning (DL) frameworks based on deep neural networks (DNN) improved accuracy in image recognition, natural language processing, and other applications yet severe data limitations and/or absence of transfer-learning-relevant problems drastically reduce advantages of DNN-based DL. Our earlier works demonstrate that hierarchical data representation can be alternatively implemented without NN, …

On The Interpretation Of The Normalization Constant In The Scaling Equation, Karl J. Niklas, Sean T. Hammond

Earth System Science and Policy Faculty Publications

The scaling equation, Y1 = βYα2, has been used empirically and explored theoretically primarily to determine the numerical value and meaning of the scaling exponent, α. The mathematical interpretation of α is clear—it is the quotient of the relative rate of change of Y1 with respect to the rate of change of Y2. In contrast, the interpretation of the normalization constant, β, is obscure, so much so that some workers have rejected the idea that it has any biological importance. With the notable exception of Steven J. Gould's early work, Huxley's dismissal of β largely relegated the study of its …

Finding Common Rules Of Robustness And Resilience That Span Multiple Levels Of Biological Organization, Robert Burnap, Jing Chen, Erica Crespi, Moumita Das, Rebecca Simmons, Zhen Wang, Jie Xiao, Bing Yang, John Yin

Biology Faculty Publications

Today, humans as a species face significant global challenges: meeting the needs of an ever expanding human population for food and energy from limited land, water and other resources; finding ways to counter rapidly changing pathogens that become resistant to current treatments; adapting to climate change that is linked to more frequent flooding, drought, wildfires and temperature extremes; and reversing the deterioration of ecosystems associated with human induced alterations of the environment. Owing to its resilience and robustness, life in one form or another will likely persist, but it is unknown by what mechanisms or in what forms. Much is …

Integrated Microfluidic Systems With Sample Preparation And Nucleic Acid Amplification, Juxin Yin, Yuanjie Suo, Zheyu Zou, Jingjing Sun, Shan Zheng, Ben Wang, Yawei Xu, Diane C. Darland, Julia Zhao, Ying Mu

Biology Faculty Publications

Rapid, efficient and accurate nucleic acid molecule detection is important in the screening of diseases and pathogens, yet remains a limiting factor at point of care (POC) treatment. Microfluidic systems are characterized by fast, integrated, miniaturized features which provide an effective platform for qualitative and quantitative detection of nucleic acid molecules. The nucleic acid detection process mainly includes sample preparation and target molecule amplification. Given the advancements in theoretical research and technological innovations to date, nucleic acid extraction and amplification integrated with microfluidic systems has advanced rapidly. The primary goal of this review is to outline current approaches used for …

Integrated Management Of Invasive Cattails (Typha Spp.) For Wetland Habitat And Biofuel In The Northern Great Plains Of The United States And Canada: A Review, Dan Svedarsky, Richard Grosshans, Henry David Venema, Susan N. Ellis-Felege, J. Bruggman, Aaron Ostlund, Jeff Lewis

Biology Faculty Publications

On many public lands in the Great Plains region of the USA and Canada, cattail (Typha spp.) growth has far exceeded the 50:50 distribution recommended for optimum wetland wildlife habitat. Excessive cattail growth is the primary concern of wetland managers and its integrated management is reviewed here. The coverage of this mostly hybrid cattail (T. latifolia × T. angustifolia) is often over 90 % and if partially removed for habitat enhancement represents a substantial biomass resource in sites such as conservation wetlands, water retention basins and roadside drainage ditches. Available biomass is estimated to be 3,000 kg/ha assuming a 50 …

The Rock, Fall/Winter 2019 (Vol. 88, No. 1), Whittier College

The Rock

No abstract provided.

Implications Of Channel Catfish Movement In An Internationally Managed System, Henry Hansen

School of Natural Resources: Dissertations, Theses, and Student Research

The large-scale movements and spatial behavior of channel catfish in the Red River of the North, have direct interactions with geopolitics, anthropogenic structures, and ecosystems. Investigating the spatial dynamics and exploitation of this mobile and internationally managed fish species provides opportunities for resource managers to design evidence­-based policy for the diverse interest groups that utilize the fishery. My thesis comprised two parts: 1) characterize system­wide movement and survival patterns using mark­-recapture methods and acoustic telemetry and 2) project the interaction of hypothetical exploitation scenarios and alternative movement methodologies to assess the fishery from an ecosystem service flow perspective. Channel catfish …

Link Rot, Reference Rot, And Link Resolvers, Justin White

University Library Publications and Presentations

From the earliest days of the web, users have been aware of the fickleness of linking to content. In some ways, 1998 was a simpler time for the Internet. In other ways, like basic website design principles, everything old is new again. Jakob Nielson, writing “Fighting Linkrot” in 1998, reported on a then-recent survey that suggested 6% of links on the web were broken. The advice then hasn’t changed: run a link validator on your site regularly, and update or remove broken links. Also set up redirects for links that do change. The mantra for Nielson was “you are not …

Role Of Sea Surface Temperatures In Forcing Circulation Anomalies Driving U.S. Great Plains Pluvial Years, Paul X. Flanagan, Jeffrey B. Basara, Jason C. Furtado, Elinor R. Martin, Xiangming Xiao

High Plains Regional Climate Center: Staff Publications

In the U.S. Great Plains (GP), diagnosing precipitation variability is key in developing an understanding of the present and future availability of water in the region. Building on previous work investigating U.S. GP pluvial years, this study usesERAtwentieth century (ERA-20C) reanalysis data to investigate key circulation anomalies driving GP precipitation anomalies during a subset of GP pluvial years (called in this paper Pattern pluvial years). With previous research showing links between tropical Pacific sea surface temperature (SST) anomalies and GP climate variability, this study diagnoses the key circulation anomalies through an analysis of SSTs and their influence on the atmosphere. …

Commencement Exercises, Texas A&M University-Commerce

All Commencement Programs

A color program for the Spring 2019 commencement ceremony at Texas A&M University-Commerce. It includes a program of events and a list of graduating students.

Nine Months In One Day: A Visual Ethnography With Caroline And Elizabeth Fox-Anvick, Kayla Ranta

Outstanding Ethnographic Research Projects

Caroline and Elizabeth Fox-Anvick, a same-sex couple residing in Bloomington, Illinois, have been married for sixteen years. Caroline and Elizabeth were the first same-sex couple to receive a foster care license in McLean County, through the Children’s Home and Aid agency. This agency began offering adoption services in 1883, and continues to help over 300 families each year (Adoption Services).

Robotic Devicewith Compact Joint Design And Related Systems And Methods, Tom Frederick, Eric Markvicka, Shane Michael Farritor, Dmitry Oleynikov

Department of Mechanical and Materials Engineering: Faculty Publications

The embodiments disclosed herein relate to various robotic and/or in vivo medical devices having compact joint configurations. Other embodiments relate to various medical device components, including forearms having grasper or cautery end effectors, that can be incorporated into certain robotic and/or in vivo medical devices.

Progress Toward The Synthesis Of Regioisomeric Aminomethyl-Substituted Qpt-1 Bacterial Topoisomerase Inhibitors, Luke Burroughs, Tuba Jaherun, Yena Jin, Nathanael Kazmierczak, Michael Barbachyn

Summer Research

Bacterial resistance to antibiotics is a growing public health threat. Each year, ~2 million infections and 23,000 deaths are caused by antibiotic resistance in the US. 1 Agents targeting the essential bacterial type II topoisomerases DNA gyrase and topoisomerase IV, as exemplified by the fluoroquinolones (FQs), have been shown to be useful antibiotics. FQs such as ciprofloxacin, moxifloxacin, and levofloxacin, to name a few, are broadspectrum antibacterial agents that have been in clinical use since the 1980's. Unfortunately, heavy use of the FQs has inevitably led to the development of FQresistant pathogens. 2 A gyrase inhibitor lead compound called QPT-1 …

Preparation Of A Novel Trifluoroborate Reagent And Initial Investigations Into Its Use In Suzuki-Miyaura Cross-Coupling Reactions., Kangjin Lee, Michael Barbachyn

Summer Research

No abstract provided.

Synthesis Of Trisubstituted Indolizines From 2-Propargyloxypyridines, Colin T. Hartgerink, Jaimie E. Van De Burg, Carolyn E. Anderson

Summer Research

• Indolizines are a versatile heterocyclic core that occurs frequently in pharmaceutical leads for a variety of indications, including: anti-bacterial1 and anti-tumor agents,2 and targets for the treatment of Alzheimer’s disease,3 asthma,4 erectile dysfunction,5 and inflammation related to respiratory or cardiovascular disease.
• While evaluating the scope of a Au(I)-catalyzed rearrangement of 2- propargyloxypyridine 1, 7 substituted indolizine 4 was discovered as an unexpected by-product (Scheme 1). The structure of indolizine 4 was confirmed by NMR and Xray analysis. Investigations revealed that acetophenone, originally present as an impurity in the reaction, is a key reagent. The use of acetophenone as the solvent, …

Plaster Creek Microbial Ecosystem And Source Tracking, Sarah Gibes, Luke Vander Meer, Kelly Dubois

Summer Research

In 2013, Plaster Creek Stewards built Kreiser Pond, a green infrastructure bioswale in East Grand Rapids that flows into Plaster Creek. It has reduced the creek’s water flow, making the creek less prone to flooding. A similar green infrastructure project was completed at Shadyside Park in Dutton in 2019. At Shadyside Park, a floodplain was built to slow the flow of the creek when there is heavy rainfall and prevent erosion caused by flooding.1 Plaster Creek’s flow rate isn’t the only concern. There is also significant microbial (bacterial and viral) contamination in Plaster Creek.2 This project investigated whether the green …